MP11-Reumatología - ibs.GRANADA

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OBJETIVO DEL GRUPO: Profundizar en la patogenia de la artritis reumatoide. Bases Genético-moleculares de la artritis reumatoide: identificación de marcadores genéticos de predisposición y pronóstico. Destacar su participación en Proyectos Nacionales e Internacionales de financiación competitiva, Colaboración en diferentes proyectos con la SER/FER y de la SAR/FAR, Colaboración en proyectos de financiación competitiva con el Instituto de Parasitología y Biomedicina López-Neyra (CSIC), con Centro de Genómica e Investigación Oncológica (GEN?O) y con la Universidad de Granada.

Líneas de investigación

Biomarcadores de pronóstico y evolución clínica
Expresión génica en enfermedades autoinmunes
Factores de respuesta a las terapias biológicas
Factores pronósticos de evolución y respuesta terapéutica
Morbilidad cardiovascular
Polimorfismos en artritis reumatoide
Riesgo cardiovascular en enfermedades reumatológicas autoinmunes

ISMAEL FRANCISCO AOMAR MILLAN

INMACULADA JIMENEZ MOLEON

PILAR MORALES GARRIDO

ENRIQUE RAYA ALVAREZ

JUAN SALVATIERRA OSSORIO

RICARDO SANCHEZ PARERA

Fernandez-Diaz, C; Castaneda, S; Melero-Gonzalez, RB; Ortiz-Sanjuan, F; Juan-Mas, A; Carrasco-Cubero, C; Casafont-Sole, I; Olive, A; Rodriguez-Muguruza, S; Almodovar-Gonzalez, R; Castellanos-Moreira, R; Rodriguez-Garcia, SC; Aguilera-Cros, C; Villa, I; Or

Abatacept in interstitial lung disease associated with rheumatoid arthritis: national multicenter study of 263 patients

RHEUMATOLOGY, 2020;

FI:5,606; Q1

Torrente-Segarra, V; Salman-Monte, TC; Rua-Figueroa, I; del Campo, V; Lopez-Longo, FJ; Galindo-Izquierdo, M; Calvo-Alen, J; Olive-Marques, A; Mourino-Rodriguez, C; Horcada, L; Bohorquez, C; Montilla, C; Salgado, E; Diez-Alvarez, E; Blanco, R; Andreu, JL;

Associated factors to serious infections in a large cohort of juvenile-onset systemic lupus erythematosus from Lupus Registry (RELESSER)

SEMINARS IN ARTHRITIS AND RHEUMATISM, 2020;

FI:4,751; Q1

Rua-Figueroa, I; Lopez-Longo, FJ; Del Campo, V; Galindo-Izquierdo, M; Uriarte, E; Torre-Cisneros, J; Vela, P; Tomero, E; Narvaez, J; Olive, A; Freire, M; Salgado, E; Andreu, JL; Martinez-Taboada, V; Calvo-Alen, J; Hernandez-Cruz, B; Raya, E; Quevedo, V; P

Bacteremia in Systemic Lupus Erythematosus in Patients from a Spanish Registry: Risk Factors, Clinical and Microbiological Characteristics, and Outcomes

JOURNAL OF RHEUMATOLOGY, 2020;

FI:3,35; Q2

Riancho-Zarrabeitia, L; Martinez-Taboada, V; Rua-Figueroa, I; Alonso, F; Galindo-Izquierdo, M; Ovalles, J; Olive-Marques, A; Fernandez-Nebro, A; Calvo-Alen, J; Menor-Almagro, R; Tomero-Muriel, E; Uriarte-Isacelaya, E; Botenau, A; Andres, M; Freire-Gonzale

Antiphospholipid syndrome (APS) in patients with systemic lupus erythematosus (SLE) implies a more severe disease with more damage accrual and higher mortality

LUPUS, 2020;

FI:2,251; Q3

Cruz, BH; Alonso, F; Alen, JC; Pego-Reigosa, JM; Lopez-Longo, FJ; Galindo-Izquierdo, M; Olive, A; Tomero, E; Horcada, L; Uriarte, E; Erausquin, C; Sanchez-Atrio, A; Montilla, C; Soler, GS; Fernandez-Nebro, A; Blanco, R; Rodriguez-Gomez, M; Vela, P; Freire

Differences in clinical manifestations and increased severity of systemic lupus erythematosus between two groups of Hispanics: European Caucasians versus Latin American mestizos (data from the RELESSER registry)

LUPUS, 2020;

FI:2,251; Q3

Lopez-Mejias, R; Carmona, FD; Genre, F; Remuzgo-Martinez, S; Gonzalez-Juanatey, C; Corrales, A; Vicente, EF; Pulito-Cueto, V; Miranda-Filloy, JA; Huaranga, MAR; Blanco, R; Robustillo-Villarino, M; Rodriguez-Carrio, J; Alperi-Lopez, M; Alegre-Sancho, JJ; Mijares, V; Lera-Gomez, L; Perez-Pampin, E; Gonzalez, A; Ortega-Castro, R; Lopez-Pedrera, C; Vivar, MLG; Gomez-Arango, C; Raya, E; Narvaez, J; Balsa, A; Lopez-Longo, FJ; Carreira, P; Gonzalez-Alvaro, I; Rodriguez-Rodriguez, L; Fernandez-Gutierrez, B; Ferraz-Amaro, I; Gualillo, O; Castaneda, S; Martin, J; Llorca, J; Gonzalez-Gay, MA

Identification of a 3 ‘-Untranslated Genetic Variant of RARB Associated With Carotid Intima-Media Thickness in Rheumatoid Arthritis: A Genome-Wide Association Study

ARTHRITIS & RHEUMATOLOGY, 2019;

FI:9,002; D1

Atienza-Mateo, B; Martin-Varillas, JL; Calvo-Rio, V; Demetrio-Pablo, R; Beltran, E; Sanchez-Burson, J; Mesquida, M; Adan, A; Hernandez, MV; Hernandez-Garfella, M; Valls-Pascual, E; Martinez-Costa, L; Sellas-Fernandez, A; Cordero-Coma, M; Diaz-Llopis, M; Gallego, R; Garcia-Serrano, JL; Ortego-Centeno, N; Herreras, JM; Fonollosa, A; Garcia-Aparicio, AM; Maiz-Alonso, O; Blanco, A; Torre-Salaberri, I; Fernandez-Espartero, C; Jovani, V; Peiteado, D; Pato, E; Cruz, J; Fernandez-Cid, C; Aurrecoechea, E; Garcia-Arias, M; Castaneda, S; Caracuel-Ruiz, MA; Montilla-Morales, CA; Atanes-Sandoval, A; Francisco, F; Insua, S; Gonzalez-Suarez, S; Sanchez-Andrade, A; Gamero, F; Ferrando, LFL; Romero-Bueno, F; Garcia-Gonzalez, AJ; Gonzalez, RA; Muro, EM; Carrasco-Cubero, C; Olive, A; Prior, A; Vazquez, J; Ruiz-Moreno, O; Jimenez-Zorzo, F; Manero, J; Fernandez, SM; Fernandez-Carballido, C; Rubio-Romero, E; Pages, FA; de Miera, FJTS; Martinez, MG; Diaz-Valle, D; Longo, FJL; Nolla, JM; Alvarez, ER; Martinez, MR; Gonzalez-Lopez, JJ; Rodriguez-Cundin, P; Hernandez, JL; Gonzalez-Gay, MA; Blanco, R

Comparative Study of Infliximab Versus Adalimumab in Refractory Uveitis due to Behcet’s Disease: National Multicenter Study of 177 Cases

ARTHRITIS & RHEUMATOLOGY, 2019;

FI:9,002; D1

Calderon-Goercke, M; Loricera, J; Aldasoro, V; Castaneda, S; Villa, I; Humbria, A; Moriano, C; Romero-Yuste, S; Narvaez, J; Gomez-Arango, C; Perez-Pampin, E; Melero, R; Becerra-Fernandez, E; Revenga, M; Alvarez-Rivas, N; Galisteo, C; Sivera, F; Olive-Marques, A; del Buergo, M; Marena-Rojas, L; Fernandez-Lopez, C; Navarro, F; Raya, E; Galindez-Agirregoikoa, E; Arca, B; Solans-Laque, R; Conesa, A; Hidalgo, C; Vazquez, C; Roman-Ivorra, J; Lluch, P; Manrique-Arija, S; Vela, P; Miguel, E; Torres-Martin, C; Nieto, J; Ordas-Calvo, C; Salgado-Perez, E; Luna-Gomez, C; de Miera, FJTS; Fernandez-Llanio, N; Garcia, A; Larena, C; Palmou-Fontana, N; Calvo-Rio, V; Prieto-Pena, D; Gonzalez-Vela, C; Corrales, A; Varela-Garcia, M; Aurrecoechea, E; Dos Santos, R; Garcia-Manzanares, A; Ortego, N; Fernandez, S; Ortiz-Sanjuan, F; Corteguera, M; Hernandez, JL; Gonzalez-Gay, MA; Blanco, R

Tocilizumab in giant cell arteritis. Observational, open-label multicenter study of 134 patients in clinical practice

SEMINARS IN ARTHRITIS AND RHEUMATISM, 2019;

FI:5,072; Q1

Ferreiro-Iglesias, A; Montes, A; Perez-Pampin, E; Canete, JD; Raya, E; Magro-Checa, C; Vasilopoulos, Y; Caliz, R; Ferrer, MA; Joven, B; Carreira, P; Balsa, A; Pascual-Salcedo, D; Blanco, FJ; Moreno-Ramos, MJ; Manrique-Arija, S; Ordonez, MD; Alegre-Sancho, JJ; Narvaez, J; Navarro-Sarabia, F; Moreira, V; Valor, L; Garcia-Portales, R; Marquez, A; Gomez-Reino, JJ; Martin, J; Gonzalez, A

Evaluation of 12 GWAS-drawn SNPs as biomarkers of rheumatoid arthritis response to TNF inhibitors. A potential SNP association with response to etanercept

PLOS ONE, 2019;

FI:2,776; Q2

Ruiz-Limon, P; Ortega-Castro, R; Barbarroja, N; Perez-Sanchez, C; Jamin, C; Patino-Trives, AM; Luque-Tevar, M; Ibanez-Costa, A; Perez-Sanchez, L; de la Rosa, IA; Abalos-Aguilera, M; Jimenez-Gomez, Y; Calvo-Gutierrez, J; Font, P; Escudero-Contreras, A; Alarcon-Riquelme, ME; Collantes-Estevez, E; Lopez-Pedrera, C; Maranon, C; Le Lann, L; Varela, N; Muchmore, B; Dufour, A; Alvarez; Chizzolini, CCM; De Langhe,; Gerl, V; De Groof, A; Ducreux, J; Trombetta, E; Li, T; Alvarez-Errico, D; Rao, S; Pers, JO; Beretta, L; AguilarQuesada, R; Aguirre-Zamorano, MA; Rubio, JLC; Castro-Villegas, MC; Cervera, R; Chizzolini, C; Collantes, E; Cornec, D; De Langhe, E; Devauchelle-Pensec, V; Espinosa, G; Roldan, MCF; Anjos, TG; Hiepe, F; Moleon, IJ; Jousse-Joulin, S; Lauwerys, B; Lopez-Berrio, A; Lories, R; Marovac, J; Meroni, PL; Miranda, B; Navarro-Linares, H; Ortega-Castro, R; Ortego, N; Pers, JO; Garrido, ER; Raya, E; Fernandez, RR; Rodriguez-Pinto, I; Saraux, A

Molecular Characterization of Monocyte Subsets Reveals Specific and Distinctive Molecular Signatures Associated With Cardiovascular Disease in Rheumatoid Arthritis

FRONTIERS IN IMMUNOLOGY, 2019;

FI:4,716; Q2

Ortiz-Fernandez, L; Carmona, FD; Lopez-Mejias, R; Gonzalez-Escribano, MF; Lyons, PA; Morgan, AW; Sawalha, AH; Smith, KGC; Gonzalez-Gay, MA; Martin, J

Cross-phenotype analysis of Immunochip data identifies KDM4C as a relevant locus for the development of systemic vasculitis

ANNALS OF THE RHEUMATIC DISEASES, 2018;

FI:12,35; D1

Gonzalez-Serna, D; Ortiz-Fernandez, L; Vargas, S; Garcia, A; Raya, E; Fernandez-Gutierrez, B; Lopez-Longo, FJ; Balsa, A; Gonzalez-Alvaro, I; Narvaez, J; Gomez-Vaquero, C; Sabio, JM; Garcia-Portales, R; Gonzalez-Escribano, MF; Tolosa, C; Carreira, P; Kiemeney, L; Coenen, MJH; Witte, T; Schneider, M; Gonzalez-Gay, MA; Martin, J

Association of a rare variant of the TNFSF13B gene with susceptibility to Rheumatoid Arthritis and Systemic Lupus Erythematosus

SCIENTIFIC REPORTS, 2018;

FI:4,122; Q1

Lopez-Rodriguez, R; Perez-Pampin, E; Marquez, A; Blanco, FJ; Joven, B; Carreira, P; Ferrer, MA; Caliz, R; Valor, L; Narvaez, J; Canete, JD; Ordonez, MD; Manrique-Arija, S; Vasilopoulos, Y; Balsa, A; Pascual-Salcedo, D; Moreno-Ramos, MJ; Alegre-Sancho, JJ; Navarro-Sarabia, F; Moreira, V; Garcia-Portales, R; Raya, E; Magro-Checa, C; Martin, J; Gomez-Reino, JJ; Gonzalez, A

Validation study of genetic biomarkers of response to TNF inhibitors in rheumatoid arthritis

PLOS ONE, 2018;

FI:2,766; Q1

Cea-Calvo, L; Raya, E; Marras, C; Salman-Monte, TC; Ortiz, A; Salvador, G; Monteagudo, I; Carmona, L; Fernandez, S; Arteaga, MJ; Calvo-Allen, J

The beliefs of rheumatoid arthritis patients in their subcutaneous biological drug: strengths and areas of concern

RHEUMATOLOGY INTERNATIONAL, 2018;

FI:1,952; Q4

Cea-Calvo, L; Raya, E; Marras, C; Salman-Monte, TC; Ortiz, A; Salvador, G; Monteagudo, I; Carmona, L; Fernandez, S; Arteaga, MJ; Calvo-Alen, J

The beliefs of rheumatoid arthritis patients in their subcutaneous biological drug: strengths and areas of concern (vol 38, pg 1735, 2018)

RHEUMATOLOGY INTERNATIONAL, 2018;

FI:1,952; Q4

Carmona, FD; Vaglio, A; Mackie, SL; Hernandez-Rodriguez, J; Monach, PA; Castaneda, S; Solans, R; Morado, IC; Narvaez, J; Ramentol-Sintas, M; Pease, CT; Dasgupta, B; Watts, R; Khalidi, N; Langford, CA; Ytterberg, S; Boiardi, L; Beretta, L; Govoni, M; Emmi, G; Bonatti, F; Cimmino, MA; Witte, T; Neumann, T; Holle, J; Schoenau, V; Sailler, L; Papo, T; Haroche, J; Mahr, A; Mouthon, L; Molberg, O; Diamantopoulos, AP; Voskuyl, A; Brouwer, E; Daikeler, T; Berger, CT; Molloy, ES; O'Neill, L; Blockmans, D; Lie, BA; Mclaren, P; Vyse, TJ; Wijmenga, C; Allanore, Y; Koeleman, BPC; Barrett, JH; Cid, MC; Salvarani, C; Merkel, PA; Morgan, AW; Gonzalez-Gay, MA; Martin, J

A Genome-wide Association Study Identifies Risk Alleles in Plasminogen and P4HA2 Associated with Giant Cell Arteritis

AMERICAN JOURNAL OF HUMAN GENETICS, 2017;

FI:9,025; D1

Garcia-Gomez, C; Martin-Martinez, MA; Castaneda, S; Sanchez-Alonso, F; Uriarte-Ecenarro, M; Gonzalez-Juanatey, C; Romera-Baures, M; Santos-Rey, J; Pinto-Tasende, JA; Quesada-Masachs, E; Tornero-Molina, J; Martinez-Gonzalez, O; Cobo-Ibanez, T; Chamizo-Carmona, E; Manrique-Arija, S; Fabregas-Canales, D; Diaz-Gonzalez, F; Llorca, J; Gonzalez-Gay, MA

Lipoprotein(a) concentrations in rheumatoid arthritis on biologic therapy: Results from the CARdiovascular in rheuMAtology study project

JOURNAL OF CLINICAL LIPIDOLOGY, 2017;

FI:5,812; D1

Garcia-Rodriguez, S; Arias-Santiago, S; Blasco-Morente, G; Orgaz-Molina, J; Rosal-Vela, A; Navarro, P; Magro-Checa, C; Martinez-Lopez, A; Ruiz, JC; Raya, E; Naranjo-Sintes, R; Sancho, J; Zubiaur, M

Increased expression of microRNA-155 in peripheral blood mononuclear cells from psoriasis patients is related to disease activity

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY, 2017;

FI:3,528; Q1

Lopez-Mejias, R; Corrales, A; Vicente, E; Robustillo-Villarino, M; Gonzalez-Juanatey, C; Llorca, J; Genre, F; Remuzgo-Martinez, S; Dierssen-Sotos, T; Miranda-Filloy, JA; Huaranga, MAR; Pina, T; Blanco, R; Alegre-Sancho, JJ; Raya, E; Mijares, V; Ubilla, B; Ferraz-Amaro, I; Gomez-Vaquero, C; Balsa, A; Lopez-Longo, FJ; Carreira, P; Gonzalez-Alvaro, I; Ocejo-Vinyals, JG; Rodriguez-Rodriguez, L; Fernandez-Gutierrez, B; Castaneda, S; Martin, J; Gonzilez-Gay, MA

Influence of coronary artery disease and subclinical atherosclerosis related polymorphisms on the risk of atherosclerosis in rheumatoid arthritis

SCIENTIFIC REPORTS, 2017;

FI:4,259; Q1

Rua-Figueroa, I; Lopez-Longo, J; Galindo-Izquierdo, M; Calvo-Alen, J; Del Campo, V; Olive-Marques, A; Perez-Vicente, S; Fernandez-Nebro, A; Andres, M; Erausquin, C; Tomero, E; Horcada, L; Uriarte, E; Freire, M; Montilla, C; Sanchez-Atrio, A; Santos, G; Boteanu, A; Diez-Alvarez, E; Narvaez, J; Martinez-Taboada, V; Silva-Fernandez, L; Ruiz-Lucea, E; Andreu, JL; Hernandez-Beriain, JA; Gantes, M; Hernandez-Cruz, B; Perez-Venegas, J; Pecondon-Espanol, A; Marras, C; Ibanez-Barcelo, M; Bonilla, G; Torrente, V; Castellvi, I; Alegre, JJ; Calvet, J; Marenco, JL; Raya, E; Vazquez, T; Quevedo, V; Munoz-Fernandez, S; Rodriguez-Gomez, M; Ibanez, J; Pego-Reigosa, JM

Incidence, associated factors and clinical impact of severe infections in a large, multicentric cohort of patients with systemic lupus erythematosus

SEMINARS IN ARTHRITIS AND RHEUMATISM, 2017;

FI:4,498; Q1

Zhao, M; Zhou, Y; Zhu, BC; Wan, MJ; Jiang, TT; Tan, QQ; Liu, Y; Jiang, JQ; Luo, SHT; Tan, YX; Wu, HJ; Renauer, P; Gutierrez, MDA; Palma, MJC; Castro, RO; Fernandez-Roldan, C; Raya, E; Faria, R; Carvalho, C; Alarcon-Riquelme, ME; Xiang, ZY; Chen, JW; Li, F; Ling, GH; Zhao, HJ; Liao, XP; Lin, YK; Sawalha, AH; Lu, QJ

IFI44L promoter methylation as a blood biomarker for systemic lupus erythematosus

ANNALS OF THE RHEUMATIC DISEASES, 2016;

FI:12,384; D1

Lopez-Mejias, R; Genre, F; Remuzgo-Martinez, S; Gonzalez-Juanatey, C; Robustillo-Villarino, M; Llorca, J; Corrales, A; Vicente, E; Miranda-Filloy, JA; Magro, C; Tejera-Segura, B; Huaranga, MAR; Pina, T; Blanco, R; Alegre-Sancho, JJ; Raya, E; Mijares, V; Ubilla, B; Sanchez, MDM; Gomez-Vaquero, C; Balsa, A; Pascual-Salcedo, D; Lopez-Longo, FJ; Carreira, P; Gonzalez-Alvaro, I; Rodriguez-Rodriguez, L; Fernandez-Gutierrez, B; Ferraz-Amaro, I; Castaneda, S; Martin, J; Gonzalez-Gay, MA

Influence of elevated-CRP level-related polymorphisms in non-rheumatic Caucasians on the risk of subclinical atherosclerosis and cardiovascular disease in rheumatoid arthritis

SCIENTIFIC REPORTS, 2016;

FI:5,228; Q1

Pego-Reigosa, JM; Lois-Iglesias, A; Rua-Figueroa, I; Galindo, M; Calvo-Alen, J; de Una-Alvarez, J; Balboa-Barreiro, V; Ruan, JI; Olive, A; Rodriguez-Gomez, M; Nebro, AF; Andres, M; Erausquin, C; Tomero, E; Rubio, LH; Isacelayam, EU; Freire, M; Montilla, C; Sanchez-Atrio, AI; Santos-Soler, G; Zea, A; Diez, E; Narvaez, J; Blanco-Alonso, R; Silva-Fernandez, L; Ruiz-Lucea, ME; Fernandez-Castro, M; Hernandez-Beriain, JA; Gantes-Mora, M; Hernandez-Cruz, B; Perez-Venegas, J; Pecondon-Espanol, A; Fernandez-Cid, CM; Ibanez-Barcelo, M; Bonilla, G; Torrente-Segarra, V; Castellvi, I; Alegre, JJ; Calvet, J; de la Fuente, JLM; Raya, E; Vazquez-Rodriguez, TR; Quevedo-Vila, V; Munoz-Fernandez, S; Oton, T; Rahman, A; Lopez-Longo, FJ

Relationship between damage clustering and mortality in systemic lupus erythematosus in early and late stages of the disease: cluster analyses in a large cohort from the Spanish Society of Rheumatology Lupus Registry

RHEUMATOLOGY, 2016;

FI:4,524; Q1

Ferreiro-Iglesias, A; Montes, A; Perez-Pampin, E; Canete, JD; Raya, E; Magro-Checa, C; Vasilopoulos, Y; Sarafidou, T; Caliz, R; Ferrer, MA; Joven, B; Carreira, P; Balsa, A; Pascual-Salcedo, D; Blanco, FJ; Moreno-Ramos, MJ; Fernandez-Nebro, A; Ordonez, MC; Alegre-Sancho, JJ; Narvaez, J; Navarro-Sarabia, F; Moreira, V; Valor, L; Garcia-Portales, R; Marquez, A; Martin, J; Gomez-Reino, JJ; Gonzalez, A

Replication of PTPRC as genetic biomarker of response to TNF inhibitors in patients with rheumatoid arthritis

PHARMACOGENOMICS JOURNAL, 2016;

FI:3,784; Q1

Gomez, MMM; Montane, E; Arellano, AL; Olive, A

Tacrolimus-induced gynecomastia in a patient with polymyositis

MEDICINA CLINICA, 2016;

FI:1,267; Q2

PsA Biológicos: Estudio observacional retrospectivo sobre los patrones de tratamiento anti-IL17 en el manejo de la artritis psoriásica. LIL-IXE-2020-01 (LY2439821)

Financiador: LILLY, S.A.

Tipo de prueba: ESTUDIO POSAUTORIZACION COMERCIAL

Tiempo de ejecución: 06/10/2020 - 30/01/2021

IP: ENRIQUE RAYA ALVAREZ

Estudio observacional de la persistencia del tratamiento en la artritis psoriasica Estudio PRO-SPIRIT. (LIL-IXE-2019-01)

Financiador: ELI LILLY AND COMPANY

Tipo de prueba: ESTUDIO POSAUTORIZACION COMERCIAL

Tiempo de ejecución: 20/10/2020 - 30/12/2025

IP: ENRIQUE RAYA ALVAREZ