MP11-Reumatología

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OBJETIVO DEL GRUPO: Profundizar en la patogenia de la artritis reumatoide. Bases Genético-moleculares de la artritis reumatoide: identificación de marcadores genéticos de predisposición y pronóstico. Destacar su participación en Proyectos Nacionales e Internacionales de financiación competitiva, Colaboración en diferentes proyectos con la SER/FER y de la SAR/FAR, Colaboración en proyectos de financiación competitiva con el Instituto de Parasitología y Biomedicina López-Neyra (CSIC), con Centro de Genómica e Investigación Oncológica (GENyO) y con la Universidad de Granada.

Líneas de investigación

Biomarcadores de pronóstico y evolución clínica
Expresión génica en enfermedades autoinmunes
Factores de respuesta a las terapias biológicas
Factores pronósticos de evolución y respuesta terapéutica
Morbilidad cardiovascular
Polimorfismos en artritis reumatoide
Riesgo cardiovascular en enfermedades reumatológicas autoinmunes

Redes de investigación

RIER - Investigación en Inflamación y Enfermedades Reumáticas

ISMAEL FRANCISCO AOMAR MILLAN

INMACULADA JIMENEZ MOLEON

ORCID

PILAR MORALES GARRIDO

Fernandez-Diaz, C; Castaneda, S; Melero-Gonzalez, RB; Ortiz-Sanjuan, F; Juan-Mas, A; Carrasco-Cubero, C; Casafont-Sole, I; Olive, A; Rodriguez-Muguruza, S; Almodovar-Gonzalez, R; Castellanos-Moreira, R; Rodriguez-Garcia, SC; Aguilera-Cros, C; Villa, I; Or

Abatacept in interstitial lung disease associated with rheumatoid arthritis: national multicenter study of 263 patients

RHEUMATOLOGY, 2020;

FI:5,606; Q1

Torrente-Segarra, V; Salman-Monte, TC; Rua-Figueroa, I; del Campo, V; Lopez-Longo, FJ; Galindo-Izquierdo, M; Calvo-Alen, J; Olive-Marques, A; Mourino-Rodriguez, C; Horcada, L; Bohorquez, C; Montilla, C; Salgado, E; Diez-Alvarez, E; Blanco, R; Andreu, JL;

Associated factors to serious infections in a large cohort of juvenile-onset systemic lupus erythematosus from Lupus Registry (RELESSER)

SEMINARS IN ARTHRITIS AND RHEUMATISM, 2020;

FI:4,751; Q1

Rua-Figueroa, I; Lopez-Longo, FJ; Del Campo, V; Galindo-Izquierdo, M; Uriarte, E; Torre-Cisneros, J; Vela, P; Tomero, E; Narvaez, J; Olive, A; Freire, M; Salgado, E; Andreu, JL; Martinez-Taboada, V; Calvo-Alen, J; Hernandez-Cruz, B; Raya, E; Quevedo, V; P

Bacteremia in Systemic Lupus Erythematosus in Patients from a Spanish Registry: Risk Factors, Clinical and Microbiological Characteristics, and Outcomes

JOURNAL OF RHEUMATOLOGY, 2020;

FI:3,35; Q2

Riancho-Zarrabeitia, L; Martinez-Taboada, V; Rua-Figueroa, I; Alonso, F; Galindo-Izquierdo, M; Ovalles, J; Olive-Marques, A; Fernandez-Nebro, A; Calvo-Alen, J; Menor-Almagro, R; Tomero-Muriel, E; Uriarte-Isacelaya, E; Botenau, A; Andres, M; Freire-Gonzale

Antiphospholipid syndrome (APS) in patients with systemic lupus erythematosus (SLE) implies a more severe disease with more damage accrual and higher mortality

LUPUS, 2020;

FI:2,251; Q3

Cruz, BH; Alonso, F; Alen, JC; Pego-Reigosa, JM; Lopez-Longo, FJ; Galindo-Izquierdo, M; Olive, A; Tomero, E; Horcada, L; Uriarte, E; Erausquin, C; Sanchez-Atrio, A; Montilla, C; Soler, GS; Fernandez-Nebro, A; Blanco, R; Rodriguez-Gomez, M; Vela, P; Freire

Differences in clinical manifestations and increased severity of systemic lupus erythematosus between two groups of Hispanics: European Caucasians versus Latin American mestizos (data from the RELESSER registry)

LUPUS, 2020;

FI:2,251; Q3

Lopez-Mejias, R; Carmona, FD; Genre, F; Remuzgo-Martinez, S; Gonzalez-Juanatey, C; Corrales, A; Vicente, EF; Pulito-Cueto, V; Miranda-Filloy, JA; Huaranga, MAR; Blanco, R; Robustillo-Villarino, M; Rodriguez-Carrio, J; Alperi-Lopez, M; Alegre-Sancho, JJ; Mijares, V; Lera-Gomez, L; Perez-Pampin, E; Gonzalez, A; Ortega-Castro, R; Lopez-Pedrera, C; Vivar, MLG; Gomez-Arango, C; Raya, E; Narvaez, J; Balsa, A; Lopez-Longo, FJ; Carreira, P; Gonzalez-Alvaro, I; Rodriguez-Rodriguez, L; Fernandez-Gutierrez, B; Ferraz-Amaro, I; Gualillo, O; Castaneda, S; Martin, J; Llorca, J; Gonzalez-Gay, MA

Identification of a 3 ‘-Untranslated Genetic Variant of RARB Associated With Carotid Intima-Media Thickness in Rheumatoid Arthritis: A Genome-Wide Association Study

ARTHRITIS & RHEUMATOLOGY, 2019;

FI:9,002; D1

Atienza-Mateo, B; Martin-Varillas, JL; Calvo-Rio, V; Demetrio-Pablo, R; Beltran, E; Sanchez-Burson, J; Mesquida, M; Adan, A; Hernandez, MV; Hernandez-Garfella, M; Valls-Pascual, E; Martinez-Costa, L; Sellas-Fernandez, A; Cordero-Coma, M; Diaz-Llopis, M; Gallego, R; Garcia-Serrano, JL; Ortego-Centeno, N; Herreras, JM; Fonollosa, A; Garcia-Aparicio, AM; Maiz-Alonso, O; Blanco, A; Torre-Salaberri, I; Fernandez-Espartero, C; Jovani, V; Peiteado, D; Pato, E; Cruz, J; Fernandez-Cid, C; Aurrecoechea, E; Garcia-Arias, M; Castaneda, S; Caracuel-Ruiz, MA; Montilla-Morales, CA; Atanes-Sandoval, A; Francisco, F; Insua, S; Gonzalez-Suarez, S; Sanchez-Andrade, A; Gamero, F; Ferrando, LFL; Romero-Bueno, F; Garcia-Gonzalez, AJ; Gonzalez, RA; Muro, EM; Carrasco-Cubero, C; Olive, A; Prior, A; Vazquez, J; Ruiz-Moreno, O; Jimenez-Zorzo, F; Manero, J; Fernandez, SM; Fernandez-Carballido, C; Rubio-Romero, E; Pages, FA; de Miera, FJTS; Martinez, MG; Diaz-Valle, D; Longo, FJL; Nolla, JM; Alvarez, ER; Martinez, MR; Gonzalez-Lopez, JJ; Rodriguez-Cundin, P; Hernandez, JL; Gonzalez-Gay, MA; Blanco, R

Comparative Study of Infliximab Versus Adalimumab in Refractory Uveitis due to Behcet’s Disease: National Multicenter Study of 177 Cases

ARTHRITIS & RHEUMATOLOGY, 2019;

FI:9,002; D1

Calderon-Goercke, M; Loricera, J; Aldasoro, V; Castaneda, S; Villa, I; Humbria, A; Moriano, C; Romero-Yuste, S; Narvaez, J; Gomez-Arango, C; Perez-Pampin, E; Melero, R; Becerra-Fernandez, E; Revenga, M; Alvarez-Rivas, N; Galisteo, C; Sivera, F; Olive-Marques, A; del Buergo, M; Marena-Rojas, L; Fernandez-Lopez, C; Navarro, F; Raya, E; Galindez-Agirregoikoa, E; Arca, B; Solans-Laque, R; Conesa, A; Hidalgo, C; Vazquez, C; Roman-Ivorra, J; Lluch, P; Manrique-Arija, S; Vela, P; Miguel, E; Torres-Martin, C; Nieto, J; Ordas-Calvo, C; Salgado-Perez, E; Luna-Gomez, C; de Miera, FJTS; Fernandez-Llanio, N; Garcia, A; Larena, C; Palmou-Fontana, N; Calvo-Rio, V; Prieto-Pena, D; Gonzalez-Vela, C; Corrales, A; Varela-Garcia, M; Aurrecoechea, E; Dos Santos, R; Garcia-Manzanares, A; Ortego, N; Fernandez, S; Ortiz-Sanjuan, F; Corteguera, M; Hernandez, JL; Gonzalez-Gay, MA; Blanco, R

Tocilizumab in giant cell arteritis. Observational, open-label multicenter study of 134 patients in clinical practice

SEMINARS IN ARTHRITIS AND RHEUMATISM, 2019;

FI:5,072; Q1

Ferreiro-Iglesias, A; Montes, A; Perez-Pampin, E; Canete, JD; Raya, E; Magro-Checa, C; Vasilopoulos, Y; Caliz, R; Ferrer, MA; Joven, B; Carreira, P; Balsa, A; Pascual-Salcedo, D; Blanco, FJ; Moreno-Ramos, MJ; Manrique-Arija, S; Ordonez, MD; Alegre-Sancho, JJ; Narvaez, J; Navarro-Sarabia, F; Moreira, V; Valor, L; Garcia-Portales, R; Marquez, A; Gomez-Reino, JJ; Martin, J; Gonzalez, A

Evaluation of 12 GWAS-drawn SNPs as biomarkers of rheumatoid arthritis response to TNF inhibitors. A potential SNP association with response to etanercept

PLOS ONE, 2019;

FI:2,776; Q2

Ruiz-Limon, P; Ortega-Castro, R; Barbarroja, N; Perez-Sanchez, C; Jamin, C; Patino-Trives, AM; Luque-Tevar, M; Ibanez-Costa, A; Perez-Sanchez, L; de la Rosa, IA; Abalos-Aguilera, M; Jimenez-Gomez, Y; Calvo-Gutierrez, J; Font, P; Escudero-Contreras, A; Alarcon-Riquelme, ME; Collantes-Estevez, E; Lopez-Pedrera, C; Maranon, C; Le Lann, L; Varela, N; Muchmore, B; Dufour, A; Alvarez; Chizzolini, CCM; De Langhe,; Gerl, V; De Groof, A; Ducreux, J; Trombetta, E; Li, T; Alvarez-Errico, D; Rao, S; Pers, JO; Beretta, L; AguilarQuesada, R; Aguirre-Zamorano, MA; Rubio, JLC; Castro-Villegas, MC; Cervera, R; Chizzolini, C; Collantes, E; Cornec, D; De Langhe, E; Devauchelle-Pensec, V; Espinosa, G; Roldan, MCF; Anjos, TG; Hiepe, F; Moleon, IJ; Jousse-Joulin, S; Lauwerys, B; Lopez-Berrio, A; Lories, R; Marovac, J; Meroni, PL; Miranda, B; Navarro-Linares, H; Ortega-Castro, R; Ortego, N; Pers, JO; Garrido, ER; Raya, E; Fernandez, RR; Rodriguez-Pinto, I; Saraux, A

Molecular Characterization of Monocyte Subsets Reveals Specific and Distinctive Molecular Signatures Associated With Cardiovascular Disease in Rheumatoid Arthritis

FRONTIERS IN IMMUNOLOGY, 2019;

FI:4,716; Q2

Ortiz-Fernandez, L; Carmona, FD; Lopez-Mejias, R; Gonzalez-Escribano, MF; Lyons, PA; Morgan, AW; Sawalha, AH; Smith, KGC; Gonzalez-Gay, MA; Martin, J

Cross-phenotype analysis of Immunochip data identifies KDM4C as a relevant locus for the development of systemic vasculitis

ANNALS OF THE RHEUMATIC DISEASES, 2018;

FI:12,35; D1

Gonzalez-Serna, D; Ortiz-Fernandez, L; Vargas, S; Garcia, A; Raya, E; Fernandez-Gutierrez, B; Lopez-Longo, FJ; Balsa, A; Gonzalez-Alvaro, I; Narvaez, J; Gomez-Vaquero, C; Sabio, JM; Garcia-Portales, R; Gonzalez-Escribano, MF; Tolosa, C; Carreira, P; Kiemeney, L; Coenen, MJH; Witte, T; Schneider, M; Gonzalez-Gay, MA; Martin, J

Association of a rare variant of the TNFSF13B gene with susceptibility to Rheumatoid Arthritis and Systemic Lupus Erythematosus

SCIENTIFIC REPORTS, 2018;

FI:4,122; Q1

Lopez-Rodriguez, R; Perez-Pampin, E; Marquez, A; Blanco, FJ; Joven, B; Carreira, P; Ferrer, MA; Caliz, R; Valor, L; Narvaez, J; Canete, JD; Ordonez, MD; Manrique-Arija, S; Vasilopoulos, Y; Balsa, A; Pascual-Salcedo, D; Moreno-Ramos, MJ; Alegre-Sancho, JJ; Navarro-Sarabia, F; Moreira, V; Garcia-Portales, R; Raya, E; Magro-Checa, C; Martin, J; Gomez-Reino, JJ; Gonzalez, A

Validation study of genetic biomarkers of response to TNF inhibitors in rheumatoid arthritis

PLOS ONE, 2018;

FI:2,766; Q1

Cea-Calvo, L; Raya, E; Marras, C; Salman-Monte, TC; Ortiz, A; Salvador, G; Monteagudo, I; Carmona, L; Fernandez, S; Arteaga, MJ; Calvo-Allen, J

The beliefs of rheumatoid arthritis patients in their subcutaneous biological drug: strengths and areas of concern

RHEUMATOLOGY INTERNATIONAL, 2018;

FI:1,952; Q4

Cea-Calvo, L; Raya, E; Marras, C; Salman-Monte, TC; Ortiz, A; Salvador, G; Monteagudo, I; Carmona, L; Fernandez, S; Arteaga, MJ; Calvo-Alen, J

The beliefs of rheumatoid arthritis patients in their subcutaneous biological drug: strengths and areas of concern (vol 38, pg 1735, 2018)

RHEUMATOLOGY INTERNATIONAL, 2018;

FI:1,952; Q4

Carmona, FD; Vaglio, A; Mackie, SL; Hernandez-Rodriguez, J; Monach, PA; Castaneda, S; Solans, R; Morado, IC; Narvaez, J; Ramentol-Sintas, M; Pease, CT; Dasgupta, B; Watts, R; Khalidi, N; Langford, CA; Ytterberg, S; Boiardi, L; Beretta, L; Govoni, M; Emmi, G; Bonatti, F; Cimmino, MA; Witte, T; Neumann, T; Holle, J; Schoenau, V; Sailler, L; Papo, T; Haroche, J; Mahr, A; Mouthon, L; Molberg, O; Diamantopoulos, AP; Voskuyl, A; Brouwer, E; Daikeler, T; Berger, CT; Molloy, ES; O'Neill, L; Blockmans, D; Lie, BA; Mclaren, P; Vyse, TJ; Wijmenga, C; Allanore, Y; Koeleman, BPC; Barrett, JH; Cid, MC; Salvarani, C; Merkel, PA; Morgan, AW; Gonzalez-Gay, MA; Martin, J

A Genome-wide Association Study Identifies Risk Alleles in Plasminogen and P4HA2 Associated with Giant Cell Arteritis

AMERICAN JOURNAL OF HUMAN GENETICS, 2017;

FI:9,025; D1

Garcia-Gomez, C; Martin-Martinez, MA; Castaneda, S; Sanchez-Alonso, F; Uriarte-Ecenarro, M; Gonzalez-Juanatey, C; Romera-Baures, M; Santos-Rey, J; Pinto-Tasende, JA; Quesada-Masachs, E; Tornero-Molina, J; Martinez-Gonzalez, O; Cobo-Ibanez, T; Chamizo-Carmona, E; Manrique-Arija, S; Fabregas-Canales, D; Diaz-Gonzalez, F; Llorca, J; Gonzalez-Gay, MA

Lipoprotein(a) concentrations in rheumatoid arthritis on biologic therapy: Results from the CARdiovascular in rheuMAtology study project

JOURNAL OF CLINICAL LIPIDOLOGY, 2017;

FI:5,812; D1

Garcia-Rodriguez, S; Arias-Santiago, S; Blasco-Morente, G; Orgaz-Molina, J; Rosal-Vela, A; Navarro, P; Magro-Checa, C; Martinez-Lopez, A; Ruiz, JC; Raya, E; Naranjo-Sintes, R; Sancho, J; Zubiaur, M

Increased expression of microRNA-155 in peripheral blood mononuclear cells from psoriasis patients is related to disease activity

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY, 2017;

FI:3,528; Q1

Lopez-Mejias, R; Corrales, A; Vicente, E; Robustillo-Villarino, M; Gonzalez-Juanatey, C; Llorca, J; Genre, F; Remuzgo-Martinez, S; Dierssen-Sotos, T; Miranda-Filloy, JA; Huaranga, MAR; Pina, T; Blanco, R; Alegre-Sancho, JJ; Raya, E; Mijares, V; Ubilla, B; Ferraz-Amaro, I; Gomez-Vaquero, C; Balsa, A; Lopez-Longo, FJ; Carreira, P; Gonzalez-Alvaro, I; Ocejo-Vinyals, JG; Rodriguez-Rodriguez, L; Fernandez-Gutierrez, B; Castaneda, S; Martin, J; Gonzilez-Gay, MA

Influence of coronary artery disease and subclinical atherosclerosis related polymorphisms on the risk of atherosclerosis in rheumatoid arthritis

SCIENTIFIC REPORTS, 2017;

FI:4,259; Q1

Rua-Figueroa, I; Lopez-Longo, J; Galindo-Izquierdo, M; Calvo-Alen, J; Del Campo, V; Olive-Marques, A; Perez-Vicente, S; Fernandez-Nebro, A; Andres, M; Erausquin, C; Tomero, E; Horcada, L; Uriarte, E; Freire, M; Montilla, C; Sanchez-Atrio, A; Santos, G; Boteanu, A; Diez-Alvarez, E; Narvaez, J; Martinez-Taboada, V; Silva-Fernandez, L; Ruiz-Lucea, E; Andreu, JL; Hernandez-Beriain, JA; Gantes, M; Hernandez-Cruz, B; Perez-Venegas, J; Pecondon-Espanol, A; Marras, C; Ibanez-Barcelo, M; Bonilla, G; Torrente, V; Castellvi, I; Alegre, JJ; Calvet, J; Marenco, JL; Raya, E; Vazquez, T; Quevedo, V; Munoz-Fernandez, S; Rodriguez-Gomez, M; Ibanez, J; Pego-Reigosa, JM

Incidence, associated factors and clinical impact of severe infections in a large, multicentric cohort of patients with systemic lupus erythematosus

SEMINARS IN ARTHRITIS AND RHEUMATISM, 2017;

FI:4,498; Q1

Zhao, M; Zhou, Y; Zhu, BC; Wan, MJ; Jiang, TT; Tan, QQ; Liu, Y; Jiang, JQ; Luo, SHT; Tan, YX; Wu, HJ; Renauer, P; Gutierrez, MDA; Palma, MJC; Castro, RO; Fernandez-Roldan, C; Raya, E; Faria, R; Carvalho, C; Alarcon-Riquelme, ME; Xiang, ZY; Chen, JW; Li, F; Ling, GH; Zhao, HJ; Liao, XP; Lin, YK; Sawalha, AH; Lu, QJ

IFI44L promoter methylation as a blood biomarker for systemic lupus erythematosus

ANNALS OF THE RHEUMATIC DISEASES, 2016;

FI:12,384; D1

Lopez-Mejias, R; Genre, F; Remuzgo-Martinez, S; Gonzalez-Juanatey, C; Robustillo-Villarino, M; Llorca, J; Corrales, A; Vicente, E; Miranda-Filloy, JA; Magro, C; Tejera-Segura, B; Huaranga, MAR; Pina, T; Blanco, R; Alegre-Sancho, JJ; Raya, E; Mijares, V; Ubilla, B; Sanchez, MDM; Gomez-Vaquero, C; Balsa, A; Pascual-Salcedo, D; Lopez-Longo, FJ; Carreira, P; Gonzalez-Alvaro, I; Rodriguez-Rodriguez, L; Fernandez-Gutierrez, B; Ferraz-Amaro, I; Castaneda, S; Martin, J; Gonzalez-Gay, MA

Influence of elevated-CRP level-related polymorphisms in non-rheumatic Caucasians on the risk of subclinical atherosclerosis and cardiovascular disease in rheumatoid arthritis

SCIENTIFIC REPORTS, 2016;

FI:5,228; Q1

Pego-Reigosa, JM; Lois-Iglesias, A; Rua-Figueroa, I; Galindo, M; Calvo-Alen, J; de Una-Alvarez, J; Balboa-Barreiro, V; Ruan, JI; Olive, A; Rodriguez-Gomez, M; Nebro, AF; Andres, M; Erausquin, C; Tomero, E; Rubio, LH; Isacelayam, EU; Freire, M; Montilla, C; Sanchez-Atrio, AI; Santos-Soler, G; Zea, A; Diez, E; Narvaez, J; Blanco-Alonso, R; Silva-Fernandez, L; Ruiz-Lucea, ME; Fernandez-Castro, M; Hernandez-Beriain, JA; Gantes-Mora, M; Hernandez-Cruz, B; Perez-Venegas, J; Pecondon-Espanol, A; Fernandez-Cid, CM; Ibanez-Barcelo, M; Bonilla, G; Torrente-Segarra, V; Castellvi, I; Alegre, JJ; Calvet, J; de la Fuente, JLM; Raya, E; Vazquez-Rodriguez, TR; Quevedo-Vila, V; Munoz-Fernandez, S; Oton, T; Rahman, A; Lopez-Longo, FJ

Relationship between damage clustering and mortality in systemic lupus erythematosus in early and late stages of the disease: cluster analyses in a large cohort from the Spanish Society of Rheumatology Lupus Registry

RHEUMATOLOGY, 2016;

FI:4,524; Q1

Ferreiro-Iglesias, A; Montes, A; Perez-Pampin, E; Canete, JD; Raya, E; Magro-Checa, C; Vasilopoulos, Y; Sarafidou, T; Caliz, R; Ferrer, MA; Joven, B; Carreira, P; Balsa, A; Pascual-Salcedo, D; Blanco, FJ; Moreno-Ramos, MJ; Fernandez-Nebro, A; Ordonez, MC; Alegre-Sancho, JJ; Narvaez, J; Navarro-Sarabia, F; Moreira, V; Valor, L; Garcia-Portales, R; Marquez, A; Martin, J; Gomez-Reino, JJ; Gonzalez, A

Replication of PTPRC as genetic biomarker of response to TNF inhibitors in patients with rheumatoid arthritis

PHARMACOGENOMICS JOURNAL, 2016;

FI:3,784; Q1

Gomez, MMM; Montane, E; Arellano, AL; Olive, A

Tacrolimus-induced gynecomastia in a patient with polymyositis

MEDICINA CLINICA, 2016;

FI:1,267; Q2

PsA Biológicos: Estudio observacional retrospectivo sobre los patrones de tratamiento anti-IL17 en el manejo de la artritis psoriásica. LIL-IXE-2020-01 (LY2439821)

Financiador: LILLY, S.A.

Tipo de prueba: ESTUDIO POSAUTORIZACION COMERCIAL

Tiempo de ejecución: 06/10/2020 - 30/01/2021

IP: ENRIQUE RAYA ALVAREZ

Estudio observacional de la persistencia del tratamiento en la artritis psoriasica Estudio PRO-SPIRIT. (LIL-IXE-2019-01)

Financiador: ELI LILLY AND COMPANY

Tipo de prueba: ESTUDIO POSAUTORIZACION COMERCIAL

Tiempo de ejecución: 20/10/2020 - 30/12/2025

IP: ENRIQUE RAYA ALVAREZ

Líneas de investigación

Redes de investigación

ISMAEL FRANCISCO AOMAR MILLAN

INMACULADA JIMENEZ MOLEON

PILAR MORALES GARRIDO

ENRIQUE RAYA ALVAREZ

JUAN SALVATIERRA OSSORIO

RICARDO SANCHEZ PARERA

Investigación