MP07-Bases Fisiopatología y Terapéutica Médica
Medicina de Precisión / IBS-MP07
Grupo de investigación dedicado a profundizar en el conocimiento de las enfermedades autoinmunes sistémicas desde el punto de vista epidemiológico, clínico, genético y de inmunología básica. Además, trabaja en el estudio de los factores de riesgo asociados con el desarrollo de osteoporosis esteroidea, así como de su prevención y tratamiento.
Líneas de investigación
- Nutrición y Enfermedades Autoinmunes Sistémicas
- Genética de Enfermedades Autoinmunes Sistémicas
- Osteoporosis corticoide
- Epidemiología de Enfermedades Autoinmunes Sistémicas
- Aspectos clínicos y complicaciones de las Enfermedades Autoinmunes
Palabras clave
Enfermedades Autoinmunes, Lupus, Esclerodermia, Vasculitis Sistémicas, Uveitis, Osteoporosis Y Glucocorticoídes.
MARIALBERT ACOSTA HERRERA
ELIO GABRIEL CARMONA RUBIO
JOSE LUIS CALLEJAS RUBIO
MARIA CORREA RODRIGUEZ
MARIA CONCEPCION FERNANDEZ ROLDAN
NORBERTO ORTEGO CENTENO
RAQUEL RIOS FERNANDEZ
BLANCA MARIA RUEDA MEDINA
A cross-disease meta-GWAS identifies four new susceptibility loci shared between systemic sclerosis and Crohn’s disease
SCIENTIFIC REPORTS, 2020;
FI:3,998; Q1
Adherence to the Mediterranean Diet in College Students: Evaluation of Psychometric Properties of the KIDMED Questionnaire
NUTRIENTS, 2020;
FI:4,546; Q1
Assessing health science students’ health literacy and its association with health behaviours
HEALTH & SOCIAL CARE IN THE COMMUNITY, 2020;
FI:2,05; Q1
Association Between Ideal Cardiovascular Health Score and Relative Handgrip Strength of Community-Dwelling Older Adults in Colombia
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION, 2020;
FI:4,367; Q1
Association between homocysteine levels and arterial stiffness in women with systemic sclerosis
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, 2020;
FI:3,319; Q2
Genome-wide meta-analysis reveals shared new loci in systemic seropositive rheumatic diseases
ANNALS OF THE RHEUMATIC DISEASES, 2019;
FI:14,299; D1
Comparative Study of Infliximab Versus Adalimumab in Refractory Uveitis due to Behcet’s Disease: National Multicenter Study of 177 Cases
ARTHRITIS & RHEUMATOLOGY, 2019;
FI:9,002; D1
Influence of Antisynthetase Antibodies Specificities on Antisynthetase Syndrome Clinical Spectrum Time Course
JOURNAL OF CLINICAL MEDICINE, 2019;
FI:5,688; D1
GWAS for systemic sclerosis identifies multiple risk loci and highlights fibrotic and vasculopathy pathways
NATURE COMMUNICATIONS, 2019;
FI:11,878; D1
Unexpected relevant role of gene mosaicism in patients with primary immunodeficiency diseases
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2019;
FI:14,11; D1
Meta-analysis of Immunochip data of four autoimmune diseases reveals novel single-disease and cross-phenotype associations
GENOME MEDICINE, 2018;
FI:8,898; D1
A large-scale genetic analysis reveals an autoimmune origin of idiopathic retroperitoneal fibrosis
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2018;
FI:13,258; D1
Successful Optimization of Adalimumab Therapy in Refractory Uveitis Due to Behcet’s Disease
OPHTHALMOLOGY, 2018;
FI:7,479; D1
Effects of 12-week Aerobic Exercise on Arterial Stiffness, Inflammation, and Cardiorespiratory Fitness in Women with Systemic LUPUS Erythematosus: Non-Randomized Controlled Trial
JOURNAL OF CLINICAL MEDICINE, 2018;
FI:5,583; D1
A TNFSF13B functional variant is not involved in systemic sclerosis and giant cell arteritis susceptibility
PLOS ONE, 2018;
FI:2,766; Q1
Very early and early systemic sclerosis in the Spanish scleroderma Registry (RESCLE) cohort
AUTOIMMUNITY REVIEWS, 2017;
FI:8,961; D1
Clinical follow-up predictors of disease pattern change in anti-Jo1 positive anti-synthetase syndrome: Results from a multicenter, international and retrospective study
AUTOIMMUNITY REVIEWS, 2017;
FI:8,961; D1
Transancestral mapping and genetic load in systemic lupus erythematosus
NATURE COMMUNICATIONS, 2017;
FI:12,124; D1
Analysis of ATP8B4 F436L Missense Variant in a Large Systemic Sclerosis Cohort
ARTHRITIS & RHEUMATOLOGY, 2017;
FI:6,918; D1
A combined large-scale meta-analysis identifies COG6 as a novel shared risk locus for rheumatoid arthritis and systemic lupus erythernatosus
ANNALS OF THE RHEUMATIC DISEASES, 2017;
FI:12,811; D1
Influence of TYK2 in systemic sclerosis susceptibility: a new locus in the IL-12 pathway
ANNALS OF THE RHEUMATIC DISEASES, 2016;
FI:12,384; D1
Groove sign
EUROPEAN JOURNAL OF INTERNAL MEDICINE, 2016;
FI:2,591; Q1
Emerging aspects of molecular biomarkers for diagnosis, prognosis and treatment response in rheumatoid arthritis
EXPERT REVIEW OF MOLECULAR DIAGNOSTICS, 2016;
FI:3,333; Q1
IRF4 Newly Identified as a Common Susceptibility Locus for Systemic Sclerosis and Rheumatoid Arthritis in a Cross-Disease Meta-Analysis of Genome-Wide Association Studies
ARTHRITIS & RHEUMATOLOGY, 2016;
FI:6,009; Q1
Genetic Analysis with the Immunochip Platform in Behcet Disease. Identification of Residues Associated in the HLA Class I Region and New Susceptibility Loci
PLOS ONE, 2016;
FI:3,057; Q1
Clinical Spectrum Time Course in Anti Jo-1 Positive Antisynthetase Syndrome Results From an International Retrospective Multicenter Study
MEDICINE, 2015;
FI:5,723; D1
PXK locus in systemic lupus erythematosus: fine mapping and functional analysis reveals novel susceptibility gene ABHD6
ANNALS OF THE RHEUMATIC DISEASES, 2015;
FI:10,377; D1
Registry of the Spanish Network for Systemic Sclerosis Survival, Prognostic Factors, and Causes of Death
MEDICINE, 2015;
FI:5,723; D1
Somatic NLRP3 mosaicism in Muckle-Wells syndrome. A genetic mechanism shared by different phenotypes of cryopyrin-associated periodic syndromes
ANNALS OF THE RHEUMATIC DISEASES, 2015;
FI:10,377; D1
Anti-TNF-alpha therapy in refractory uveitis associated with sarcoidosis: Multicenter study of 17 patients
SEMINARS IN ARTHRITIS AND RHEUMATISM, 2015;
FI:3,925; Q1
Detección Precoz de Osteoporosis: Identificación de Factores Genéticos Implicados en la Mineralización Ósea en Adultos Jóvenes
Financiador: FUNDACION PUBLICA ANDALUZA PROGRESO Y SALUD
Número de expediente: PI-0414-2014
Tiempo de ejecución: 31/07/2015 - 01/08/2017
IP: BLANCA MARIA RUEDA MEDINA
Identificación de Factores Genéticos Implicados en el Desarrollo de Úlceras Digitales en Pacientes de Esclerodermia Mediante Un Estudio de Asociación del Genoma Completo (Gwas)
Financiador: FUNDACION PUBLICA ANDALUZA PROGRESO Y SALUD
Número de expediente: PI-0390-2014
Tiempo de ejecución: 31/07/2015 - 01/08/2017
Lydimed: Lupus y Dieta Mediterránea
Financiador: CONSEJERÍA DE SALUD
Número de expediente: PI-0523-2016
Tiempo de ejecución: 01/01/2017 - 31/12/2019
IP: NORBERTO ORTEGO CENTENO
Identificación de Factores Genéticos de Riesgo Compartidos Entre Enfermedades Reumáticas Mediante Una Estrategia Meta-Immunochip
Financiador: CONSEJERÍA DE SALUD
Número de expediente: PI-0493-2016
Tiempo de ejecución: 01/01/2017 - 31/12/2019
IP: RAQUEL RIOS FERNANDEZ
Study of the molecular basis of giant cell arteritis by integrating genomic, transcriptomic and methylation data.
Financiador: INSTITUTO DE SALUD CARLOS III
Número de expediente: CP17/00008-P
Tiempo de ejecución: 01/01/2018 - 31/12/2020
Identificación de los mecanismos patogénicos implicados en el desarrollo de la arteritis de células gigantes mediante secuenciación del transcriptoma de células T individuales
Financiador: INSTITUTO DE SALUD CARLOS III
Número de expediente: PI18/00040
Tiempo de ejecución: 01/01/2019 - 31/12/2021
Ensayo clínico de Sarilumab en adultos hospitalizados con COVID-19 que presentan síndrome de liberación de citoquinas (SARICOR)
Financiador: FUNDACION UNIVERSITARIA PARA EL DESARROLLO DE LA PROVINCIA DE CORDOBA
Tipo de prueba: ENSAYO CLINICO INDEPENDIENTE
Tiempo de ejecución: 07/05/2020 -
IP: MARIA CONCEPCION FERNANDEZ ROLDAN
CDC Ensayo clínico abierto y multicéntrico para evaluar la efectividad y seguridad de tocilizumab intravenoso en el tratamiento de pacientes con neumonía por COVID-19. Estudio BREATH-19
Financiador: FUNDACION SEIMC-GESIDA
Tipo de prueba: ENSAYO CLINICO INDEPENDIENTE
Tiempo de ejecución: 22/05/2020 - 20/11/2020
IP: JOSE LUIS CALLEJAS RUBIO