TERAPIAS AVANZADAS: DIFERENCIACIÓN, REGENERACIÓN Y CÁNCER
Grupos de investigación IBS-TEC-16
TERAPIAS AVANZADAS: DIFERENCIACIÓN, REGENERACIÓN Y CÁNCER
La investigación del grupo se centra en dos ejes principales, la medicina regenerativa y la oncología experimental, no solo en los aspectos básicos, sino que también es claramente traslacional e interdisciplinar, con aplicación en diagnóstico y el uso terapéutico para beneficiar la salud de pacientes con enfermedades de alta prevalencia, como son las enfermedades degenerativas y el cáncer. Esta orientación multi e interdisciplinar tiene como base el uso de los conocimientos en nanotecnología y nanomedicina para cumplir los objetivos anteriores.
Lineas de investigación
- Aplicación terapéutica de células madre adultas y progenitoras en patologías
- Bioimpresión 3D de tumores, tumores-on-a-chip y metástasis-on-chip
- Bioimpresión 3D y desarrollo de biotintas y generación de biomateriales naturales y sintéticos con aplicación patologías prevalentes
- Biopsia líquida: identificación de nuevos biomarcadores y vesículas extracelulares característicos de CSCs con valor pronóstico y predictivo de respuesta en pacientes con cáncer
- Desarrollo de biorreactores con aplicación en medicina regenerativa
- Desarrollo de modelos preclínicos para nuevos tratamientos útiles en medicina regenerativa y cáncer.
- Desarrollo de nanosistemas biológicos basados en membranas celulares (noghosts)
- Desarrollo de nuevos dispositivos médicos para el tratamiento del cáncer (ultrasonidos)
- Desarrollo de plataformas químicas para la detección de ácidos nucleicos
- Implementación de nanomedicinas teranósticas inteligentes
- Implementación de una plataforma integrada no invasiva basada en el uso de la bioinformática, la nanotecnología y biosensores de grafeno
- Integración de nanotecnología con química dinámica como herramienta diagnóstica
- Nuevos fármacos naturales y sintéticos selectivos frente a CSCs
- Organoides-on-a-chip
- Papel de las células madre cancerígenas (CSCs) y su microambiente en el desarrollo tumoral.
- Terapia génica del cáncer: genes suicidas y sistemas CAR-T para tumores sólidos
- Uso de citoquinas quiméricas en diferenciación celular
Palabras clave
células madre, células madre cancerígenas, bioimpresión 3D, labs-on-chip, nanopartículas, nanofantasmas, teragnosis, exosomas, biopsia líquida, terapia génica, genes suicidas, bioreactores, dispositivos médicos, química dinámica, biosensores.
| Miembro |
|---|
| GRIÑÁN LISÓN, CARMEN |
| ARREBOLA VARGAS, FRANCISCO JESÚS |
| PALACIOS FERRER, JOSE LUIS |
| LUQUE GONZÁLEZ, Mª ANGÉLICA |
| DÍAZ MOCHÓN, JUAN JOSÉ |
| PALOMEQUE JIMÉNEZ, ANTONIO |
| PICÓN RUIZ, MANUEL |
| ANTICH ACEDO, CRISTINA |
| AGUILERA GÓMEZ, MARGARITA |
| CARRILLO DELGADO, ESMERALDA |
| DELGADO GONZÁLEZ, ANTONIO |
| BOULAIZ TASSI, HOURIA |
| CANO CORTÉS, VICTORIA |
| NAVARRO MARCHAL, SAÚL ABENHAMAR |
| LOPEZ DELGADO, FRANCISCO JAVIER |
| SÁNCHEZ MARTÍN, ROSARIO MARÍA |
| CHOCARRO WRONA, CARLOS |
| MARCHAL CORRALES, JUAN ANTONIO |
| GARCÍA CHAVES, MARÍA ÁNGEL |
| RUIZ ALCALÁ, GLORIA |
| HACKENBERG, MICHAEL |
| JIMENEZ GONZALEZ, GEMA |
| GARCÍA ORTEGA, M. BELÉN |
| ROBLES REMACHO, AGUSTIN |
| RUIZ BLAS, MARÍA PAZ |
| LÓPEZ RUIZ, ELENA |
Inventores: AGUILERA GOMEZ MARGARITA; ARANEGA JIMENEZ ANTONIA; CALLEJA HERNANDEZ MIGUEL ANGEL ; CARRASCO PARDO ESTHER ; ESTEBAN RODRIGUEZ MARIANO ; GARCIA CHAVES MARIA ANGEL ; JIMENEZ GONZALEZ GEMA ; MARCHAL CORRALES JUAN ANTONIO ;
Título: METODO DE OBTENCION DE DATOS UTILES PARA EVALUAR LA RESPUESTA AL TRATAMIENTO CON 5-FLUOROURACILO (5-FU)
Código: P201130247
Inventores: ARANEGA JIMENEZ ANTONIA ; BOULAIZ HOURIA ; CAMPOS ROSA JOAQUIN MARIA ; CATIVIELA MARIN CARLOS ; CHOQUESILLO-LAZARTE DUANE; CONEJO GARCIA ANA ; CRUZ LOPEZ OLGA ; GARCIA CHAVES MARIA ANGEL ; GARCIA RUIZ JUAN MANUEL ; JIMENEZ SANZ ANA ISABEL; MARCHAL
Título: DIANAS BENZOHETEROEPINICOS
Código: P201030415
Inventores: A. Aránega; ALVAREZ DE MANZANEDA ROLDAN ENRIQUE; CHAHBOUN RACHID; F. Rodríguez Serrano; I. Messouri; H. Boulaiz; J.A. Marchal; C. Melguizo; M. Perán; J. Prados ;
Título: ANALOGOS SINTETICOS DE MEROSESQUITERPENOS Y COMPUESTOS RELACIONADOS CON ACTIVIDAD ANTITUMORAL
Código: P201050019
Inventores: Campos JM; Lopez l; Marchal JA; Boulaiz H; Aránega A; Gallo MA; Espinosa A; Rodríguez-Serrano F; Conejo, Ana
Título: NUEVAS (RS)- 7- O 9- (1,2,3,5- TETRAHIDRO-4,1-BENZOCAZEPIN-3-IL)-7H O9H-PURINAS CON ACTIVIDAD ANTITUMORAL
Código: P200802431
Inventores: ARANEGA JIMENEZ ANTONIA ; CAMPOS ROSA JOAQUIN ; ESPINOSA UBEDA ANTONIO ; GALLO MEZO MIGUEL ANGEL ; GOMEZ VIDAL JOSE ANTONIO ; NUNEZ CARRETERO M DEL CARMEN; MARCHAL CORRALES JUAN ANTONIO; Rodriguez-Serrano F ;
Título: (2,3-DIHIDRO-5H-1,4-BENZODIHETEROEPIN-3-IL)PURINAS CON ACTIVIDAD ANTITUMORAL
Código: P200601538
Safety evaluation of the food enzyme glucose oxidase from Aspergillus niger (strain ZGL)
Efsa Journal, 2019; ;
FI: 4.016; Q1 / D3
Safety evaluation of the food enzyme glucan 1,4-alpha-maltotetraohydrolase from Bacillus licheniformis (strain DP-Dzr46)
Efsa Journal, 2019; ;
FI: 4.016; Q1 / D3
Safety evaluation of the food enzyme alpha-amylase and 1,4-alpha-glucan 6-alpha-glucosyltransferase from Paenibacillus alginolyticus.
Efsa journal, 2019; ;
FI: 4.016; Q1 / D3
Safety evaluation of the food enzyme triacylglycerol lipase from Aspergillus niger (strain LFS)
Efsa Journal, 2019; ;
FI: 4.016; Q1 / D3
Marín-Romero A, Robles-Remacho A, Tabraue-Chávez M, López-Longarela B, Sánchez-Martín RM, Guardia-Monteagudo JJ, Fara MA, López-Delgado FJ, Pernagallo S, Díaz-Mochón JJ
A PCR-free technology to detect and quantify microRNAs directly from human plasma.
The Analyst, 2018; 143(23); 5676-5682
FI: 3.864; Q1 / D2
González-González A, Muñoz-Muela E, Marchal JA, Cara FE, Molina MP, Cruz-Lozano M, Jiménez G, Verma A, Ramírez A, Qian W, Chen W, Kozielski AJ, Elemento O, Martín-Salvago MD, Luque RJ, Rosa-Garrido C, Landeira D, Quintana-Romero M, Rosato RR, García MA, Ramirez-Tortosa CL, Kim H, Rodriguez-Aguayo C, Lopez-Berestein G, Sood AK, Lorente JA, Sánchez-Rovira P, Chang JC, Granados-Principal S
Activating Transcription Factor 4 Modulates TGFβ-Induced Aggressiveness in Triple-Negative Breast Cancer via SMAD2/3/4 and mTORC2 Signaling.
Clinical cancer research : an official journal of the American Association for Cancer Research, 2018; 24(22); 5697-5709
FI: 10.199; Q1 / D1
Sánchez-Moreno P, de Vicente J, Nardecchia S, Marchal JA, Boulaiz H
Thermo-Sensitive Nanomaterials: Recent Advance in Synthesis and Biomedical Applications.
Nanomaterials (Basel, Switzerland), 2018; 8(11);
FI: 3.504; Q1 / D3
Hernández-Camarero P, Jiménez G, López-Ruiz E, Barungi S, Marchal JA, Perán M
Revisiting the dynamic cancer stem cell model: Importance of tumour edges.
Critical reviews in oncology/hematology, 2018; 131; 35-45
FI: 4.495; Q1 / D3
Valero T, Delgado-González A, Unciti-Broceta JD, Cano-Cortés V, Pérez-López AM, Unciti-Broceta A, Sánchez Martín RM
Drug "Clicking" on Cell-Penetrating Fluorescent Nanoparticles for In Cellulo Chemical Proteomics.
Bioconjugate chemistry, 2018; 29(9); 3154-3160
FI: 4.485; Q1 / D2
Jiménez G, Hackenberg M, Catalina P, Boulaiz H, Griñán-Lisón C, García MÁ, Perán M, López-Ruiz E, Ramírez A, Morata-Tarifa C, Carrasco E, Aguilera M, Marchal JA
Mesenchymal stem cell's secretome promotes selective enrichment of cancer stem-like cells with specific cytogenetic profile.
Cancer letters, 2018; 429; 78-88
FI: 6.491; Q1 / D2
González-González A, Muñoz-Muela E, Marchal JA, Cara FE, Molina MP, Cruz-Lozano M, Jiménez G, Verma A, Ramírez A, Qian W, Chen W, Kozielski AJ, Elemento O, Martín-Salvago MD, Luque RJ, Rosa-Garrido C, Landeira D, Quintana-Romero M, Rosato RR, García MA, Ramirez-Tortosa CL, Kim H, Rodriguez-Aguayo C, Lopez-Berestein G, Sood AK, Lorente JA, Sánchez-Rovira P, Chang JC, Granados-Principal S
Activating Transcription Factor 4 Modulates TGFβ-Induced Aggressiveness in Triple-Negative Breast Cancer via SMAD2/3/4 and mTORC2 Signaling.
Clin Cancer Res, 2018; ;
FI: 10.199; Q1 / D1
Galisteo-González F, Molina-Bolívar JA, Navarro SA, Boulaiz H, Aguilera-Garrido A, Ramírez A, Marchal JA
Albumin-covered lipid nanocapsules exhibit enhanced uptake performance by breast-tumor cells.
Colloids and surfaces. B, Biointerfaces, 2018; 165; 103-110
FI: 3.997; Q1 / D2
Melchor, J; Lopez-Ruiz, E; Soto, J; Jimenez, G; Antich, C; Peran, M; Baena, JM; Marchal, JA; Rus, G
In-bioreactor ultrasonic monitoring of 3D culture human engineered cartilage
SENSORS AND ACTUATORS B-CHEMICAL, 2018; 266;
FI: 5.667; Q1 / D1
Ramírez A, Conejo-García A, Griñán-Lisón C, López-Cara LC, Jiménez G, Campos JM, Marchal JA, Boulaiz H
Gene Mediated Therapy and New 1,4-Benzoxazepin-2,6-Dichloropurine Derivatives in Breast Cancer Cells.
Frontiers in pharmacology, 2018; 9; 798
FI: 3.831; Q1 / D2
Angélica Luque-González M, Tabraue-Chávez M, López-Longarela B, María Sánchez-Martín R, Ortiz-González M, Soriano-Rodríguez M, Antonio García-Salcedo J, Pernagallo S, José Díaz-Mochón J
Identification of Trypanosomatids by detecting Single Nucleotide Fingerprints using DNA analysis by dynamic chemistry with MALDI-ToF.
Talanta, 2018; 176; 299-307
FI: 4.244; Q1 / D2
Silano Vittorio, Bolognesi Claudia, Castle Laurence, Chipman Kevin, Cravedi Jean-Pierre, Fowler Paul, Franz Roland, Grob Konrad, Gurtler Rainer, Husoy Trine, Karenlampi Sirpa, Mennes Wim, Milana Maria Rosaria, Pfaff Karla, Riviere Gilles, Srinivasan Jannavi, de Fatima Maria, Pocas Tavares, Tlustos Christina, Wolfle Detlef, Zorn Holger, Chesson Andrew, Glandorf Boet, Herman Lieve, Jany Klaus-Dieter, Marcon Francesca, Penninks Andre, Smith Andrew, Zeljezic Davor, Aguilera-Gomez Margarita, Andryszkiewicz Magdalena, Arcella Davide, Kovalkovicova Natalia, Liu Yi, Maia Joaquim, Engel Karl-Heinz, Mat EFSA Panel Food Contact
Safety evaluation of the food enzyme xylanase from a genetically modified Bacillussubtilis strain TD160(229)
Efsa Journal, 2018; 16;
FI: 12.244; Q1 / D1
Silano Vittorio, Bolognesi Claudia, Castle Laurence, Chipman Kevin, Cravedi Jean-Pierre, Fowler Paul, Franz Roland, Grob Konrad, Gurtler Rainer, Husoy Trine, Karenlampi Sirpa, Mennes Wim, Milana Maria Rosaria, Pfaff Karla, Riviere Gilles, Srinivasan Jannavi, Pocas Maria de Fatima Tavares, Tlustos Christina, Wolfle Detlef, Zorn Holger, Chesson Andrew, Glandorf Boet, Herman Lieve, Jany Klaus-Dieter, Marcon Francesca, Penninks Andre, Smith Andrew, van Loveren Henk, Zeljezic Davor, Aguilera-Gomez Margarita, Andryszkiewicz Magdalena, Arcella Davide, Kovalkovicova Natalia, Liu Yi, Engel Karl-Heinz, Materia Efsa Panel Food Contact
Safety evaluation of the food enzyme maltogenic amylase from a genetically modified Bacillus subtilis (strain NZYM-SM)
Efsa Journal, 2018; 16;
FI: 12.244; Q1 / D1
Silano Vittorio, Baviera Jose Manuel Barat, Bolognesi Claudia, Bruschweiler Beat Johannes, Cocconcelli Pier Sandro, Crebelli Riccardo, Gott David Michael, Grob Konrad, Lampi Evgenia, Mortensen Alicja, Rivier Gilles, Steffensen Inger-Lise, Tlustos Christina, Van Loveren Henk, Penninks Andre, Zeljezic Davor, Aguilera-Gomez Margarita, Andryszkiewicz Magdalena, Arcella Davide, Kovalkovitova Natalia, Liu Yi, Pena Claudia Roncancio, Horn Christine, Chesson Andrew, Enzyme EFSA Panel Food Contact Mat
Safety evaluation of the food enzyme endo-1,4-beta-xylanase from a genetically modified Aspergillus oryzae (strain NZYM-FA)
Efsa Journal, 2018; 16;
FI: 12.244; Q1 / D1
Silano Vittorio, Bolognesi Claudia, Castle Laurence, Chipman Kevin, Cravedi Jean-Pierre, Fowler Paul, Franz Roland, Grob Konrad, Gurtler Rainer, Husoy Trine, Karenlampi Sirpa, Mennes Wim, Milana Maria Rosaria, Pfaff Karla, Riviere Gilles, Srinivasan Jannavi, Pocas Maria de Fatima Tavares, Tlustos Christina, Wolfle Detlef, Zorn Holger, Chesson Andrew, Glandorf Boet, Herman Lieve, Jany Klaus-Dieter, Marcon Francesca, Penninks Andre, Smith Andrew, van Loveren Henk, Zeljezic Davor, Aguilera-Gomez Margarita, Arcella Davide, Kovalkovicova Natalia, Maia Joaquim, Liu Yi, Engel Karl-Heinz, Mat EFSA Panel Food Contact
Safety evaluation of the food enzyme endo-1,4-beta-xylanase from a genetically modified Aspergillus niger (strain XEA)
Efsa Journal, 2018; 16;
FI: 12.244; Q1 / D1
Silano Vittorio, Bolognesi Claudia, Castle Laurence, Chipman Kevin, Cravedi Jean-Pierre, Fowler Paul, Franz Roland, Grob Konrad, Gurtler Rainer, Husoy Trine, Karenlampi Sirpa, Mennes Wim, Milana Maria Rosaria, Pfaff Karla, Riviere Gilles, Srinivasan Jannavi, Tavares Pocas Maria de Fatima, Tlustos Christina, Wolfle Detlef, Zorn Holger, Chesson Andrew, Glandorf Boet, Herman Lieve, Jany Klaus-Dieter, Marcon Francesca, Penninks Andre, Smith Andrew, Van Loveren Henk, Zeljezic Davor, Aguilera-Gomez Margarita, Andryszkiewicz Magdalena, Arcella Davide, Kovalkovicova Natalia, Liu Yi, Engel Karl-Heinz, Mat EFSA Panel Food Contact
Safety evaluation of the food enzyme alpha-amylase from a genetically modified Aspergillus niger (strain NZYM-SB)
Efsa Journal, 2018; 16;
FI: 12.244; Q1 / D1
Silano Vittorio, Baviera Jose Manuel Barat, Bolognesi Claudia, Bruschweiler Beat Johannes, Cocconcelli Pier Sandro, Crebelli Riccardo, Gott David Michael, Grob Konrad, Lampi Evgenia, Mortensen Alicja, Riviere Gilles, Steffensen Inger-Lise, Tlustos Christina, van Loveren Henk, Vernis Laurence, Zorn Holger, Karenlampi Sirpa, Marcon Francesca, Penninks Andre, Smith Andrew, Aguilera-Gomez Margarita, Andryszkiewicz Magdalena, Arcella Davide, Kovalkovicova Natalia, Liu Yi, Rossi Annamaria, Engel Karl-Heinz, Chesson Andrew, Mat EFSA Panel Food Contact
Safety evaluation of the food enzyme alpha-amylase from a genetically modified Aspergillus niger (strain NZYM-MC)
Efsa Journal, 2018; 16;
FI: 12.244; Q1 / D1
Jimenez Gema, Hackenberg Michael, Catalina Purificacion, Boulaiz Houria, Grinan-Lison Carmen, Garcia Maria Angel, Peran Macarena, Lopez-Ruiz Elena, Ramirez Alberto, Morata-Tarifa Cynthia, Carrasco Esther, Aguilera Margarita, Marchal Juan Antonio
Mesenchymal stem cell's secretome promotes selective enrichment of cancer stem-like cells with specific cytogenetic profile.
Cancer letters, 2018; ;
FI: 6.491; Q1 / D2
Jimenez Gema, Hackenberg Michael, Catalina Purificación, Boulaiz Houria, Griñán-lisón Carmen, Ángel García María, Perán Macarena, López-Ruiz Elena, Ramírez Alberto, Morata-Tarifa Cynthia, Carrasco Esther, Aguilera Margarita, Marchal-Corrales Juan Antonio
Mesenchymal stem cell's secretome promotes selective enrichment of cancer stem-like cells with specific cytogenetic profile
Cancer Letters, 2018; 429; 78-88
FI: 6.491; Q1 / D2
Perán M, López-Ruiz E, García MÁ, Nadaraia-Hoke S, Brandt R, Marchal JA, Kenyon J
A formulation of pancreatic pro-enzymes provides potent anti-tumour efficacy: a pilot study focused on pancreatic and ovarian cancer.
Scientific reports, 2017; 7(1); 13998
FI: 4.122; Q1 / D2
Kim M, Jang K, Miller P, Picon-Ruiz M, Yeasky TM, El-Ashry D, Slingerland JM
VEGFA links self-renewal and metastasis by inducing Sox2 to repress miR-452, driving Slug.
Oncogene, 2017; 36(36); 5199-5211
FI: 6.854; Q1 / D2
Picon-Ruiz M, Morata-Tarifa C, Valle-Goffin JJ, Friedman ER, Slingerland JM
Obesity and adverse breast cancer risk and outcome: Mechanistic insights and strategies for intervention.
CA: a cancer journal for clinicians, 2017; 67(5); 378-397
FI: 244.585; Q1 / D1
Kapravelou G, Martínez R, Nebot E, López-Jurado M, Aranda P, Arrebola F, Cantarero S, Galisteo M, Porres JM
The Combined Intervention with Germinated Vigna radiata and Aerobic Interval Training Protocol Is an Effective Strategy for the Treatment of Non-Alcoholic Fatty Liver Disease (NAFLD) and Other Alterations Related to the Metabolic Syndrome in Zucker Rats.
Nutrients, 2017; 9(7);
FI: 4.196; Q1 / D2
Altea-Manzano P, Unciti-Broceta JD, Cano-Cortes V, Ruiz-Blas MP, Valero-Griñan T, Diaz-Mochon JJ, Sanchez-Martin R
Tracking cell proliferation using a nanotechnology-based approach.
Nanomedicine (London, England), 2017; 12(13); 1591-1605
FI: 5.005; Q1 / D2
Cruz-López O, Ramírez A, Navarro SA, García MA, Marchal JA, Campos JM, Conejo-García A
1-(Benzenesulfonyl)-1,5-dihydro-4,1-benzoxazepine as a new scaffold for the design of antitumor compounds.
Future medicinal chemistry, 2017; 9(11); 1129-1140
FI: 3.969; Q1 / D2
López-Ruiz E, Venkateswaran S, Perán M, Jiménez G, Pernagallo S, Díaz-Mochón JJ, Tura-Ceide O, Arrebola F, Melchor J, Soto J, Rus G, Real PJ, Diaz-Ricart M, Conde-González A, Bradley M, Marchal JA
Poly(ethylmethacrylate-co-diethylaminoethyl acrylate) coating improves endothelial re-population, bio-mechanical and anti-thrombogenic properties of decellularized carotid arteries for blood vessel replacement.
Scientific reports, 2017; 7(1); 407
FI: 4.122; Q1 / D2
Morales F, Ramírez A, Morata-Tarifa C, Navarro SA, Marchal JA, Campos JM, Conejo-García A
Antitumoral activity of 1,2-diaminocyclohexane derivatives in breast, colon and skin human cancer cells.
Future medicinal chemistry, 2017; 9(3); 293-302
FI: 3.969; Q1 / D2
Morata-Tarifa C, Picon-Ruiz M, Griñan-Lison C, Boulaiz H, Perán M, Garcia MA, Marchal JA
Validation of suitable normalizers for miR expression patterns analysis covering tumour heterogeneity.
Scientific reports, 2017; 7; 39782
FI: 4.122; Q1 / D2
Morata Tarifa C., Picon Ruiz M., Griñan Lison C., Boulaiz H., Perán M., Garcia MA., Marchal JA.
Validation of suitable normalizers for miR expression patterns analysis covering tumour heterogeneity.
Scientific reports, 2017; 7; 39782
FI: 4.122; Q1 / D1
Silano Vittorio, Bolognesi Claudia, Castle Laurence, Cravedi Jean-Pierre, Fowler Paul, Franz Roland, Grob Konrad, Gurtler Rainer, Husoy Trine, Karenlampi Sirpa, Mennes Wim, Milana Maria Rosaria, Penninks Andre, Smith Andrew, Pocas Maria de Fatima Tavares, Tlustos Christina, Wolfle Detlef, Zorn Holger, Zugravu Corina-Aurelia, Chesson Andrew, Glandorf Boet, Herman Lieve, Jany Klaus-Dieter, Marcon Francesca, Zeljezic Davor, Aguilera-Gomez Margarita, Kovalkovicova Natalia, Maia Joaquim, Engel Karl-Heinz, Materials EFSA Panel Food Contact
Safety evaluation of the food enzyme pullulanase from genetically modified Bacillus subtilis strain NZYM-AK
Efsa Journal, 2017; 15;
FI: 12.244; Q1 / D1
Silano Vittorio, Bolognesi Claudia, Castle Laurence, Chipman Kevin, Cravedi Jean-Pierre, Fowler Paul, Franz Roland, Grob Konrad, Guertler Rainer, Husoy Trine, Kaerenlampi Sirpa, Mennes Wim, Milana Maria Rosaria, Pfaff Karla, Riviere Gilles, Srinivasan Jannavi, Pocas Maria de Fatima Tavares, Tlustos Christina, Woelfle Detlef, Zorn Holger, Chesson Andrew, Glandorf Boet, Herman Lieve, Jany Klaus-Dieter, Marcon Francesca, Penninks Andre, Smith Andrew, Zeljezic Davor, Andryszkiewicz Magdalena, Aguilera-Gomez Margarita, Kovalkovicova Natalia, Liu Yi, Engel Karl-Heinz, Enzyme EFSA Panel Food Contact Mat
Safety evaluation of the food enzyme pullulanase from Pullulanibacillus naganoensis strain AE-PL
Efsa Journal, 2017; 15;
FI: 12.244; Q1 / D1
Silano V., Bolognesi C., Castle L., Cravedi J. P., Fowler P., Franz R., Grob K., Gurtler R., Husoy T., Karenlampi S., Mennes W., Milana M. R., Penninks A., Smith A., Pocas M. D. T., Tlustos C., Wolfle D., Zorn H., Zugravu C. A., Chesson A., Glandorf B., Hermann L., Jany K. D., Marcon F., Zeljezic D., Aguilera-Gomez M., Andryszkiewicz M., Arcella D., Kovalkovicova N., Liu Y., Engel K. H., Enzy Essa Panel Food Contact Mat
Safety evaluation of the food enzyme endo-1,4-b-xylanase from genetically modified Aspergillus niger strain XYL
Efsa Journal, 2017; 15;
FI: 12.244; Q1 / D1
Rissin DM, López-Longarela B, Pernagallo S, Ilyine H, Vliegenthart ADB, Dear JW, Díaz-Mochón JJ, Duffy DC
Polymerase-free measurement of microRNA-122 with single base specificity using single molecule arrays: Detection of drug-induced liver injury.
PloS one, 2017; 12(7); e0179669
FI: 2.766; Q1 / D3
Venkateswaran S, Luque-González MA, Tabraue-Chávez M, Fara MA, López-Longarela B, Cano-Cortes V, López-Delgado FJ, Sánchez-Martín RM, Ilyine H, Bradley M, Pernagallo S, Díaz-Mochón JJ
Novel bead-based platform for direct detection of unlabelled nucleic acids through Single Nucleobase Labelling.
Talanta, 2016; 161; 489-496
FI: 4.162; Q1 / D2
Messina L, Gavira JA, Pernagallo S, Unciti-Broceta JD, Sanchez Martin RM, Diaz-Mochon JJ, Vaccaro S, Conejero-Muriel M, Pineda-Molina E, Caruso S, Musumeci L, Di Pasquale R, Pontillo A, Sincinelli F, Pavan M, Secchieri C
Identification and characterization of a bacterial hyaluronidase and its production in recombinant form.
FEBS letters, 2016; 590(14); 2180-9
FI: 3.623; Q1 / D3
Picon-Ruiz M, Pan C, Drews-Elger K, Jang K, Besser AH, Zhao D, Morata-Tarifa C, Kim M, Ince TA, Azzam DJ, Wander SA, Wang B, Ergonul B, Datar RH, Cote RJ, Howard GA, El-Ashry D, Torné-Poyatos P, Marchal JA, Slingerland JM
Interactions between Adipocytes and Breast Cancer Cells Stimulate Cytokine Production and Drive Src/Sox2/miR-302b-Mediated Malignant Progression.
Cancer research, 2016; 76(2); 491-504
FI: 9.122; Q1 / D1
Morata-Tarifa C, Jiménez G, García MA, Entrena JM, Griñán-Lisón C, Aguilera M, Picon-Ruiz M, Marchal JA
Low adherent cancer cell subpopulations are enriched in tumorigenic and metastatic epithelial-to-mesenchymal transition-induced cancer stem-like cells.
Scientific reports, 2016; 6; 18772
FI: 4.259; Q1 / D2
Farace C, Sánchez-Moreno P, Orecchioni M, Manetti R, Sgarrella F, Asara Y, Peula-García JM, Marchal JA, Madeddu R, Delogu LG
Immune cell impact of three differently coated lipid nanocapsules: pluronic, chitosan and polyethylene glycol.
Scientific reports, 2016; 6; 18423
FI: 4.259; Q1 / D2
Morata-Tarifa C., Jimenez G., Garcia M. A., Entrena J. M., Grinan-Lison C., Aguilera M., Picon-Ruiz M., Marchal J. A.
Low adherent cancer cell subpopulations are enriched in tumorigenic and metastatic epithelial-to-mesenchymal transition-induced cancer stem-like cells
Scientific Reports, 2016; 6; 13-13
FI: 4.259; Q1 / D2
Morata Tarifa C., Jiménez G., García MA., Entrena JM., Griñán Lisón C., Aguilera M., Picon Ruiz M., Marchal JA.
Low adherent cancer cell subpopulations are enriched in tumorigenic and metastatic epithelial-to-mesenchymal transition-induced cancer stem-like cells.
Scientific reports, 2016; 6; 18772
FI: 4.259; Q1 / D2
Jiménez G, López-Ruiz E, Kwiatkowski W, Montañez E, Arrebola F, Carrillo E, Gray PC, Izpisua Belmonte JC, Choe S, Perán M, Marchal JA
Activin A/BMP2 chimera AB235 drives efficient redifferentiation of long term cultured autologous chondrocytes.
Scientific reports, 2015; 5; 16400
FI: 5.228; Q1 / D1
Sánchez-Moreno P, Buzón P, Boulaiz H, Peula-García JM, Ortega-Vinuesa JL, Luque I, Salvati A, Marchal JA
Balancing the effect of corona on therapeutic efficacy and macrophage uptake of lipid nanocapsules.
Biomaterials, 2015; 61; 266-78
FI: 8.387; Q1 / D1
Zhao D, Pan C, Sun J, Gilbert C, Drews-Elger K, Azzam DJ, Picon-Ruiz M, Kim M, Ullmer W, El-Ashry D, Creighton CJ, Slingerland JM
VEGF drives cancer-initiating stem cells through VEGFR-2/Stat3 signaling to upregulate Myc and Sox2.
Oncogene, 2015; 34(24); 3107-19
FI: 7.932; Q1 / D1
Unciti-Broceta JD, Cano-Cortés V, Altea-Manzano P, Pernagallo S, Díaz-Mochón JJ, Sánchez-Martín RM
Number of Nanoparticles per Cell through a Spectrophotometric Method - A key parameter to Assess Nanoparticle-based Cellular Assays.
Scientific reports, 2015; 5; 10091
FI: 5.228; Q1 / D1
Pineda de las Infantas MJ, Torres-Rusillo S, Unciti-Broceta JD, Fernandez-Rubio P, Luque-Gonzalez MA, Gallo MA, Unciti-Broceta A, Molina IJ, Diaz-Mochon JJ
Synthesis of 6,8,9 poly-substituted purine analogue libraries as pro-apoptotic inducers of human leukemic lymphocytes and DAPK-1 inhibitors.
Organic & biomolecular chemistry, 2015; 13(18); 5224-34
FI: 3.559; Q1 / D3
Roman S, Agil A, Peran M, Alvaro-Galue E, Ruiz-Ojeda FJ, Fernández-Vázquez G, Marchal JA
Brown adipose tissue and novel therapeutic approaches to treat metabolic disorders.
Translational research : the journal of laboratory and clinical medicine, 2015; 165(4); 464-79
FI: 4.557; Q1 / D1
Kapravelou G, Martínez R, Andrade AM, López Chaves C, López-Jurado M, Aranda P, Arrebola F, Cañizares FJ, Galisteo M, Porres JM
Improvement of the antioxidant and hypolipidaemic effects of cowpea flours (Vigna unguiculata) by fermentation: results of in vitro and in vivo experiments.
Journal of the science of food and agriculture, 2015; 95(6); 1207-16
FI: 2.076; Q1 / D1
Ortega FG, Lorente JA, Garcia Puche JL, Ruiz MP, Sanchez-Martin RM, de Miguel-Pérez D, Diaz-Mochon JJ, Serrano MJ
miRNA in situ hybridization in circulating tumor cells--MishCTC.
Scientific reports, 2015; 5; 9207
FI: 5.228; Q1 / D1
Conejero-Muriel M, Gavira JA, Pineda-Molina E, Belsom A, Bradley M, Moral M, García-López Durán Jde D, Luque González A, Díaz-Mochón JJ, Contreras-Montoya R, Martínez-Peragón Á, Cuerva JM, Álvarez de Cienfuegos L
Influence of the chirality of short peptide supramolecular hydrogels in protein crystallogenesis.
Chemical communications (Cambridge, England), 2015; 51(18); 3862-5
FI: 6.567; Q1 / D2
Goumenou M., Aguilera-Gomez M., Andrysziewicz M., Nielsen K. R., Theobald A., Roncancio-Pena C.
Hazard identification and characterization of food enzymes
Toxicology Letters, 2015; 238; S350-S350
FI: 3.522; Q1 / D2
Carrillo E, Navarro SA, Ramírez A, García MÁ, Griñán-Lisón C, Perán M, Marchal JA
5-Fluorouracil derivatives: a patent review (2012 - 2014).
Expert opinion on therapeutic patents, 2015; 25(10); 1131-44
FI: 4.626; Q1 / D1
Ortega FG, Fernández-Baldo MA, Fernández JG, Serrano MJ, Sanz MI, Diaz-Mochón JJ, Lorente JA, Raba J
Study of antitumor activity in breast cell lines using silver nanoparticles produced by yeast.
International journal of nanomedicine, 2015; 10; 2021-31
FI: 4.32; Q1 / D2
Pineda de las Infantas y Villatoro MJ, Unciti-Broceta JD, Contreras-Montoya R, Garcia-Salcedo JA, Gallo Mezo MA, Unciti-Broceta A, Diaz-Mochon JJ
Amide-controlled, one-pot synthesis of tri-substituted purines generates structural diversity and analogues with trypanocidal activity.
Scientific reports, 2015; 5; 9139
FI: 5.228; Q1 / D1
Pietrovito L, Cano-Cortés V, Gamberi T, Magherini F, Bianchi L, Bini L, Sánchez-Martín RM, Fasano M, Modesti A
Cellular response to empty and palladium-conjugated amino-polystyrene nanospheres uptake: a proteomic study.
Proteomics, 2015; 15(1); 34-43
FI: 4.079; Q1 / D2
de la Cruz-Herrera CF, Campagna M, García MA, Marcos-Villar L, Lang V, Baz-Martínez M, Gutiérrez S, Vidal A, Rodríguez MS, Esteban M, Rivas C
Activation of the double-stranded RNA-dependent protein kinase PKR by small ubiquitin-like modifier (SUMO).
The Journal of biological chemistry, 2014; 289(38); 26357-67
FI: 4.573; Q1 / D3
Serrano MJ, Ortega FG, Alvarez-Cubero MJ, Nadal R, Sanchez-Rovira P, Salido M, Rodríguez M, García-Puche JL, Delgado-Rodriguez M, Solé F, García MA, Perán M, Rosell R, Marchal JA, Lorente JA
EMT and EGFR in CTCs cytokeratin negative non-metastatic breast cancer.
Oncotarget, 2014; 5(17); 7486-97
FI: 6.359; Q1 / D1
Cárdenas-Maestre JM, Pérez-López AM, Bradley M, Sánchez-Martín RM
Microsphere-based intracellular sensing of caspase-3/7 in apoptotic living cells.
Macromolecular bioscience, 2014; 14(7); 923-8
FI: 3.851; Q1 / D2
Ramírez A, Boulaiz H, Morata-Tarifa C, Perán M, Jiménez G, Picon-Ruiz M, Agil A, Cruz-López O, Conejo-García A, Campos JM, Sánchez A, García MA, Marchal JA
HER2-signaling pathway, JNK and ERKs kinases, and cancer stem-like cells are targets of Bozepinib small compound.
Oncotarget, 2014; 5(11); 3590-606
FI: 6.359; Q1 / D1
Gerasimidis K, Bertz M, Hanske L, Junick J, Biskou O, Aguilera M, Garrick V, Russell RK, Blaut M, McGrogan P, Edwards CA
Decline in presumptively protective gut bacterial species and metabolites are paradoxically associated with disease improvement in pediatric Crohn's disease during enteral nutrition.
Inflammatory bowel diseases, 2014; 20(5); 861-71
FI: 4.464; Q1 / D2
Marchal JA, Lopez GJ, Peran M, Comino A, Delgado JR, García-García JA, Conde V, Aranda FM, Rivas C, Esteban M, Garcia MA
The impact of PKR activation: from neurodegeneration to cancer.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2014; 28(5); 1965-74
FI: 5.043; Q1 / D1
Morales F, Ramírez A, Conejo-García A, Morata C, Marchal JA, Campos JM
Anti-proliferative activity of 2,6-dichloro-9- or 7-(ethoxycarbonylmethyl)-9H- or 7H-purines against several human solid tumour cell lines.
European journal of medicinal chemistry, 2014; 76; 118-24
FI: 3.447; Q1 / D2
Aguilera-Gomez Margarita
Decline in presumptively protective gut bacterial species and metabolites are paradoxically associated with disease improvement in paediatric Crohn¿s disease during enteral nutrition
Inflammatory Bowel Diseases, 2014; ;
FI: 4.464; Q1 / D2
Gomez-Llorente Carolina, Plaza-Diaz Julio, Aguilera Margarita, Munoz-Quezada Sergio, Bermudez-Brito Miriam, Peso-Echarri Patricia, Martinez-Silla Rosario, Isabel Vasallo-Morillas M., Campana-Martin Laura, Vives-Pinera Inmaculada, Ballesta-Martinez Maria J., Gil Angel
Three Main Factors Define Changes in Fecal Microbiota Associated With Feeding Modality in Infants
Journal of Pediatric Gastroenterology and Nutrition, 2014; 57; 461-466
FI: 2.625; Q1 / D2
Gerasimidis K., Bertz M., Hanske L., Junick J., Biskou O., Aguilera M., Garrick V., Russell R. K., Blaut M., McGrogan P., Edwards C. A.
Changes in dominant gut microbial species and metabolites in children with Crohn's disease during exclusive enteral nutrition
Proceedings of the Nutrition Society, 2014; 73; E33-E33
FI: 5.273; Q1 / D1
Sánchez-Moreno P, Ortega-Vinuesa JL, Boulaiz H, Marchal JA, Peula-García JM
Synthesis and characterization of lipid immuno-nanocapsules for directed drug delivery: selective antitumor activity against HER2 positive breast-cancer cells.
Biomacromolecules, 2013; 14(12); 4248-59
FI: 5.788; Q1 / D1
Gomez-Llorente C, Plaza-Diaz J, Aguilera M, Muñoz-Quezada S, Bermudez-Brito M, Peso-Echarri P, Martinez-Silla R, Vasallo-Morillas MI, Campaña-Martin L, Vives-Piñera I, Ballesta-Martinez MJ, Gil A
Three main factors define changes in fecal microbiota associated with feeding modality in infants.
Journal of pediatric gastroenterology and nutrition, 2013; 57(4); 461-6
FI: 2.873; Q1 / D2
Agil A, Reiter RJ, Jiménez-Aranda A, Ibán-Arias R, Navarro-Alarcón M, Marchal JA, Adem A, Fernández-Vázquez G
Melatonin ameliorates low-grade inflammation and oxidative stress in young Zucker diabetic fatty rats.
Journal of pineal research, 2013; 54(4); 381-8
FI: 7.812; Q1 / D1
Peran M, Ruiz S, Kwiatkowski W, Marchal JA, Yang SL, Aranega A, Choe S, Izpisua Belmonte JC
Activin/BMP2 chimeric ligands direct adipose-derived stem cells to chondrogenic differentiation.
Stem cell research, 2013; 10(3); 464-76
FI: 4.467; Q1 / D2
G. Kapravelou, R. Martínez, Am. Andrade, C. Sánchez, C. López Chaves, M. López-Jurado, P. Aranda, S. Cantarero, F. Arrebola, E. Fernández-Segura, M. Galisteo, JM. Porres
Health Promoting Effects of Lupin (Lupinus albus var multolupa) Protein Hydrolyzate and Insoluble Fiber in a Diet-Induced Animal Experimental Model of Hypercholesterolemia.
Food Research International, 2013; 54;
FI: 3.05; Q1 / D2
García-Rubiño ME, Conejo-García A, Núñez MC, Carrasco E, García MA, Choquesillo-Lazarte D, García-Ruiz JM, Gallo MA, Marchal JA, Campos JM
Enantiospecific synthesis of heterocycles linked to purines: different apoptosis modulation of enantiomers in breast cancer cells.
Current medicinal chemistry, 2013; 20(38); 4924-34
FI: 3.715; Q1 / D2
López-Ruiz E, Perán M, Cobo-Molinos J, Jiménez G, Picón M, Bustamante M, Arrebola F, Hernández-Lamas MC, Delgado-Martínez AD, Montañez E, Marchal JA
Chondrocytes extract from patients with osteoarthritis induces chondrogenesis in infrapatellar fat pad-derived stem cells.
Osteoarthritis and cartilage, 2013; 21(1); 246-58
FI: 4.663; Q1 / D1
Olmo F, Marín C, Clares MP, Blasco S, Albelda MT, Soriano C, Gutiérrez-Sánchez R, Arrebola-Vargas F, García-España E, Sánchez-Moreno M
Scorpiand-like azamacrocycles prevent the chronic establishment of Trypanosoma cruzi in a murine model.
European journal of medicinal chemistry, 2013; 70; 189-98
FI: 3.432; Q1 / D3
Unciti-Broceta A, Díaz-Mochón JJ, Sánchez-Martín RM, Bradley M
The use of solid supports to generate nucleic acid carriers.
Accounts of chemical research, 2012; 45(7); 1140-52
FI: 20.833; Q1 / D1
Sánchez-Moreno M, Marín C, Navarro P, Lamarque L, García-España E, Miranda C, Huertas O, Olmo F, Gómez-Contreras F, Pitarch J, Arrebola F
In vitro and in vivo trypanosomicidal activity of pyrazole-containing macrocyclic and macrobicyclic polyamines: their action on acute and chronic phases of Chagas disease.
Journal of medicinal chemistry, 2012; 55(9); 4231-43
FI: 5.614; Q1 / D1
Caba O, Rodríguez-Serrano F, Díaz-Gavilán M, Conejo-García A, Ortiz R, Martínez-Amat A, Alvarez P, Gallo MA, Campos JM, Marchal JA, Aránega A
The selective cytotoxic activity in breast cancer cells by an anthranilic alcohol-derived acyclic 5-fluorouracil O,N-acetal is mediated by endoplasmic reticulum stress-induced apoptosis.
European journal of medicinal chemistry, 2012; 50; 376-82
FI: 3.499; Q1 / D3
Marchal JA, Picón M, Perán M, Bueno C, Jiménez-Navarro M, Carrillo E, Boulaiz H, Rodríguez N, Álvarez P, Menendez P, de Teresa E, Aránega A
Purification and long-term expansion of multipotent endothelial-like cells with potential cardiovascular regeneration.
Stem cells and development, 2012; 21(4); 562-74
FI: 4.67; Q1 / D1
Álvarez P, Marchal JA, Boulaiz H, Carrillo E, Vélez C, Rodríguez-Serrano F, Melguizo C, Prados J, Madeddu R, Aranega A
5-Fluorouracil derivatives: a patent review.
Expert opinion on therapeutic patents, 2012; 22(2); 107-23
FI: 3.525; Q1 / D1
Pernagallo S, Ventimiglia G, Cavalluzzo C, Alessi E, Ilyine H, Bradley M, Diaz-Mochon JJ
Novel biochip platform for nucleic acid analysis.
Sensors (Basel, Switzerland), 2012; 12(6); 8100-11
FI: 1.953; Q1 / D2
Prados J, Alvarez PJ, Melguizo C, Rodriguez-Serrano F, Carrillo E, Boulaiz H, Vélez C, Marchal JA, Caba O, Ortiz R, Rama A, Aranega A
How is gene transfection able to improve current chemotherapy? The role of combined therapy in cancer treatment.
Current medicinal chemistry, 2012; 19(12); 1870-88
FI: 4.07; Q1 / D1
González-Santamaría J, Campagna M, García MA, Marcos-Villar L, González D, Gallego P, Lopitz-Otsoa F, Guerra S, Rodríguez MS, Esteban M, Rivas C
Regulation of vaccinia virus E3 protein by small ubiquitin-like modifier proteins.
Journal of virology, 2011; 85(24); 12890-900
FI: 5.402; Q1 / D2
Jiménez-Navarro MF, Caballero-Borrego J, Rodriguez-Losada N, Cabrera-Bueno F, Marchal JA, Estebaranz J, Muñoz-García A, Perán M, Pérez R, Ramírez G, Hernández-García JM, Aránega A, de Teresa Galván E
Influence of preinfarction angina on the release kinetics of endothelial progenitor cells and cytokines during the week after infarction.
European journal of clinical investigation, 2011; 41(11); 1220-6
FI: 3.018; Q1 / D2
Svensen N, Díaz-Mochón JJ, Bradley M
Decoding a PNA encoded peptide library by PCR: the discovery of new cell surface receptor ligands.
Chemistry & biology, 2011; 18(10); 1284-9
FI: 5.829; Q1 / D2
Caba O, Díaz-Gavilán M, Rodríguez-Serrano F, Boulaiz H, Aránega A, Gallo MA, Marchal JA, Campos JM
Anticancer activity and cDNA microarray studies of a (RS)-1,2,3,5-tetrahydro-4,1-benzoxazepine-3-yl]-6-chloro-9H-purine, and an acyclic (RS)-O,N-acetalic 6-chloro-7H-purine.
European journal of medicinal chemistry, 2011; 46(9); 3802-9
FI: 3.346; Q1 / D3
Conejo-García A, García-Rubiño ME, Marchal JA, Núñez MC, Ramírez A, Cimino S, García MÁ, Aránega A, Gallo MA, Campos JM
Synthesis and anticancer activity of (RS)-9-(2,3-dihydro-1,4-benzoxaheteroin-2-ylmethyl)-9H-purines.
European journal of medicinal chemistry, 2011; 46(9); 3795-801
FI: 3.346; Q1 / D3
Svensen N, Díaz-Mochón JJ, Bradley M
Encoded peptide libraries and the discovery of new cell binding ligands.
Chemical communications (Cambridge, England), 2011; 47(27); 7638-40
FI: 6.169; Q1 / D2
Svensen N, Díaz-Mochón JJ, Dhaliwal K, Planonth S, Dewar M, Armstrong JD, Bradley M
Screening of a combinatorial homing peptide library for selective cellular delivery.
Angewandte Chemie (International ed. in English), 2011; 50(27); 6133-6
FI: 13.455; Q1 / D1
Sánchez-Moreno M, Sanz AM, Gómez-Contreras F, Navarro P, Marín C, Ramírez-Macias I, Rosales MJ, Olmo F, Garcia-Aranda I, Campayo L, Cano C, Arrebola F, Yunta MJ
In vivo trypanosomicidal activity of imidazole- or pyrazole-based benzo[g]phthalazine derivatives against acute and chronic phases of Chagas disease.
Journal of medicinal chemistry, 2011; 54(4); 970-9
FI: 5.248; Q1 / D1
Perán M, Sánchez-Ferrero A, Tosh D, Marchal JA, Lopez E, Alvarez P, Boulaiz H, Rodríguez-Serrano F, Aranega A
Ultrastructural and molecular analyzes of insulin-producing cells induced from human hepatoma cells.
Cytotherapy, 2011; 13(2); 193-200
FI: 3.627; Q1 / D3
Angel Garcia Maria, Carrasco Esther, Aguilera Margarita, Alvarez Pablo, Rivas Carmen, Maria Campos Joaquin, Carlos Prados Jose, Angel Calleja Miguel, Esteban Mariano, Antonio Marchal Juan, Aranega Antonia
The Chemotherapeutic Drug 5-Fluorouracil Promotes PKR-Mediated Apoptosis in a p53-Independent Manner in Colon and Breast Cancer Cells
Plos One, 2011; 6;
FI: 4.092; Q1 / D2
Macia A, Muñoz-Lopez M, Cortes JL, Hastings RK, Morell S, Lucena-Aguilar G, Marchal JA, Badge RM, Garcia-Perez JL
Epigenetic control of retrotransposon expression in human embryonic stem cells.
Molecular and cellular biology, 2011; 31(2); 300-16
FI: 5.527; Q1 / D2
Campagna M, Herranz D, Garcia MA, Marcos-Villar L, González-Santamaría J, Gallego P, Gutierrez S, Collado M, Serrano M, Esteban M, Rivas C
SIRT1 stabilizes PML promoting its sumoylation.
Cell death and differentiation, 2011; 18(1); 72-9
FI: 8.849; Q1 / D1
López-Cara LC, Conejo-García A, Marchal JA, Macchione G, Cruz-López O, Boulaiz H, García MA, Rodríguez-Serrano F, Ramírez A, Cativiela C, Jiménez AI, García-Ruiz JM, Choquesillo-Lazarte D, Aránega A, Campos JM
New (RS)-benzoxazepin-purines with antitumour activity: The chiral switch from (RS)-2,6-dichloro-9-[1-(p-nitrobenzenesulfonyl)-1,2,3,5-tetrahydro-4,1-benzoxazepin-3-yl]-9H-purine.
European journal of medicinal chemistry, 2011; 46(1); 249-58
FI: 3.346; Q1 / D3
García MA, Carrasco E, Aguilera M, Alvarez P, Rivas C, Campos JM, Prados JC, Calleja MA, Esteban M, Marchal JA, Aránega A
The chemotherapeutic drug 5-fluorouracil promotes PKR-mediated apoptosis in a p53-independent manner in colon and breast cancer cells.
PloS one, 2011; 6(8); e23887
FI: 4.092; Q1 / D2
Rojo Venegas K, Aguilera Gómez M, Eisman JA, García Sánchez A, Faus Dader MJ, Calleja Hernández MA
Pharmacogenetics of osteoporosis-related bone fractures: moving towards the harmonization and validation of polymorphism diagnostic tools.
Pharmacogenomics, 2010; 11(9); 1287-303
FI: 3.876; Q1 / D2
Rojo K. P., Aguilera M., Canadas M., Lopez J., Navarro-Pelayo M., Llamas J., Garcia A., Calleja M. A.
Pilot assay for comparison of bone mineral density and genetic polymorphisms in patients with risk of hip fractures
European Journal of Nuclear Medicine and Molecular Imaging, 2010; 37; S472-S472
FI: 5.036; Q1 / D1
Rodríguez-Serrano F, Ríos A, Marchal JA, Caba O, Martínez-Amat A, Prados J, Melguizo C, Ortiz R, Perán M, Boulaiz H, Vélez C, Alvarez P, Aránega A
Differentiation of intestinal epithelial cells mediated by cell confluence and/or exogenous nucleoside supplementation.
Cells, tissues, organs, 2010; 191(6); 478-88
FI: 2.302; Q1 / D2
Perán M, Hooper H, Marchal JA, Boulaiz H, Rodríguez-Serrano F, Velez C, Aránega A, Salas R
Cell surface immobilization of GABAA Rs in cerebellar granule cells depends on the M3/M4 cytoplasmatic loop of the alpha 1 subunit.
Cells, tissues, organs, 2009; 189(6); 420-4
FI: 3.322; Q1 / D1
Marchal JA, Núñez MC, Aránega A, Gallo MA, Espinosa A, Campos JM
Acyclonucleosides, modified seco-nucleosides, and salicyl- or catechol-derived acyclic 5-fluorouracil O,N-acetals: antiproliferative activities, cellular differentiation and apoptosis.
Current medicinal chemistry, 2009; 16(9); 1166-83
FI: 4.708; Q1 / D1
Garcia MA, Gallego P, Campagna M, González-Santamaría J, Martínez G, Marcos-Villar L, Vidal A, Esteban M, Rivas C
Activation of NF-kB pathway by virus infection requires Rb expression.
PloS one, 2009; 4(7); e6422
FI: 4.351; Q1 / D2
Aguilera M, Quesada MT, Del Aguila VG, Morillo JA, Rivadeneyra MA, Ramos-Cormenzana A, Monteoliva-Sánchez M
Characterisation of Paenibacillus jamilae strains that produce exopolysaccharide during growth on and detoxification of olive mill wastewaters.
Bioresource technology, 2008; 99(13); 5640-4
FI: 4.453; Q1 / D1
Boulaiz H, Prados J, Melguizo C, Marchal JA, Carrillo E, Peran M, Rodríguez-Serrano F, Martínez-Amat A, Caba O, Hita F, Concha A, Aránega A
Tumour malignancy loss and cell differentiation are associated with induction of gef gene in human melanoma cells.
The British journal of dermatology, 2008; 159(2); 370-8
FI: 3.489; Q1 / D1
Aguilera Margarita, Teresa Quesada Maria, Guerra del Aguila Victor, Antonio Morillo Jose, Angustias Rivadeneyra Maria, Ramos-Cormenzana Alberto, Monteoliva-Sanchez Mercedes
Characterisation of Paenibacillus jamilae strains that produce exopolysaccharide during growth on and detoxification of olive mill wastewaters
Bioresource Technology, 2008; 99; 5640-5644
FI: 4.453; Q1 / D1
Díaz-Gavilán M, Conejo-García A, Cruz-López O, Núñez MC, Choquesillo-Lazarte D, González-Pérez JM, Rodríguez-Serrano F, Marchal JA, Aránega A, Gallo MA, Espinosa A, Campos JM
Synthesis and anticancer activity of (R,S)-9-(2,3-dihydro-1,4-benzoxathiin-3-ylmethyl)-9H-purines.
ChemMedChem, 2008; 3(1); 127-35
FI: 3.15; Q1 / D2
Marchal JA, Rodríguez-Serrano F, Caba O, Aránega A, Gallo MA, Espinosa A, Campos JM
Antiproliferative activity, cell-cycle dysregulation, and cellular differentiation: salicyl- and catechol-derived acyclic 5-fluorouracil O,N-acetals against breast cancer cells.
ChemMedChem, 2007; 2(12); 1814-21
FI: 2.825; Q1 / D2
Marchal JA, Núñez MC, Suárez I, Díaz-Gavilán M, Gómez-Vidal JA, Boulaiz H, Rodríguez-Serrano F, Gallo MA, Espinosa A, Aránega A, Campos JM
A synthetic uracil derivative with antitumor activity through decreasing cyclin D1 and Cdk1, and increasing p21 and p27 in MCF-7 cells.
Breast cancer research and treatment, 2007; 105(3); 237-46
FI: 4.453; Q1 / D1
Martínez Amat A, Marchal Corrales JA, Rodríguez Serrano F, Boulaiz H, Prados Salazar JC, Hita Contreras F, Caba Perez O, Carrillo Delgado E, Martín I, Aranega Jimenez A
Role of alpha-actin in muscle damage of injured athletes in comparison with traditional markers.
British journal of sports medicine, 2007; 41(7); 442-6
FI: 2.463; Q1 / D1
Aguilera M, Cabrera A, Incerti C, Fuentes S, Russell NJ, Ramos-Cormenzana A, Monteoliva-Sánchez M
Chromohalobacter salarius sp. nov., a moderately halophilic bacterium isolated from a solar saltern in Cabo de Gata, Almeria, southern Spain.
International journal of systematic and evolutionary microbiology, 2007; 57(Pt 6); 1238-42
FI: 2.384; Q1 / D3
Quesada T, Aguilera M, Morillo JA, Ramos-Cormenzana A, Monteoliva-Sánchez M
Virgibacillus olivae sp. nov., isolated from waste wash-water from processing of Spanish-style green olives.
International journal of systematic and evolutionary microbiology, 2007; 57(Pt 5); 906-10
FI: 2.384; Q1 / D3
Rodríguez-Serrano F, Marchal JA, Ríos A, Martínez-Amat A, Boulaiz H, Prados J, Perán M, Caba O, Carrillo E, Hita F, Aránega A
Exogenous nucleosides modulate proliferation of rat intestinal epithelial IEC-6 cells.
The Journal of nutrition, 2007; 137(4); 879-84
FI: 3.771; Q1 / D1
Cabrera A, Aguilera M, Fuentes S, Incerti C, Russell NJ, Ramos-Cormenzana A, Monteoliva-Sánchez M
Halomonas indalinina sp. nov., a moderately halophilic bacterium isolated from a solar saltern in Cabo de Gata, Almeria, southern Spain.
International journal of systematic and evolutionary microbiology, 2007; 57(Pt 2); 376-80
FI: 2.384; Q1 / D3
Nunez, MC; Rodriguez-Serrano, F; Marchal, JA; Caba, O; Aranega, A; Gallo, MA; Espinosa, A; Campos, JM
6’-Chloro-7- or 9-(2,3-dihydro-5H-4,1-benzoxathiepin-3-yl)-7H- or 9H-purines and their corresponding sulfones as a new family of cytotoxic drugs
Tetrahedron, 2007; 63.0;
FI: 2.869; Q1 / D2
Quesada Teresa, Aguilera Margarita, Morillo Jose Antonio, Ramos-Cormenzana Alberto, Monteoliva-Sanchez Mercedes
Virgibacillus olivae sp nov., isolated from waste wash-water from processing of Spanish-style green olives
International Journal of Systematic and Evolutionary Microbiology, 2007; 57; 906-910
FI: 2.384; Q1 / D3
Cabrera Antonio, Aguilera Margarita, Fuentes Susana, Incerti Claudia, Russell Nick J., Monteoliva-Sanchez Mercedes
Halomonas indalinina sp nov., a moderately halophilic bacterium isolated from a solar saltern in Cabo de Gata, Almeria, southern Spain
International Journal of Systematic and Evolutionary Microbiology, 2007; 57; 376-380
FI: 2.384; Q1 / D3
Aguilera Margarita, Cabrera Antonio, Incerti Claudia, Fuentes Susana, Russell Nick J., Ramos-Cormenzana Alberto, Monteoliva-Sanchez Mercedes
Chromohalobacter salarius sp nov., a moderately halophilic bacterium isolated from a solar saltern in Cabo de Gata, Almeria, southern Spain
International Journal of Systematic and Evolutionary Microbiology, 2007; 57; 1238-1242
FI: 2.384; Q1 / D3
Prado Bernardo, Lizama Catherine, Aguilera Margarita, Ramos-Cormenzana Alberto, Fuentes Susana, Campos Victoriano, Monteoliva-Sanchez Mercedes
Chromohalobacter nigrandesensis sp. nov., a moderately halophilic, gram-negative bacterium isolated from Lake Tebenquiche on the Atacama Saltern, Chile (Vol 56, pg 647, 2006)
International Journal of Systematic and Evolutionary Microbiology, 2007; 57; 2725-2725
FI: 2.384; Q1 / D3
