BIOQUÍMICA DE LA NUTRICIÓN. IMPLICACIONES TERAPÉUTICAS
Grupos de investigación IBS-MP-22
BIOQUÍMICA DE LA NUTRICIÓN. IMPLICACIONES TERAPÉUTICAS
Nuestro grupo de investigación Bioquímica de la Nutrición. Implicaciones terapéuticas, BioNIT, con referencia CTS-461 del Plan Andaluz de Investigación, Desarrollo e Innovación (PAIDI), se constituyó en el año 1996 y está formado actualmente por 14 personas, siendo el investigador principal (IP) el Dr. Ángel Gil Hernández. Sus integrantes se dedican tanto a la docencia como a la investigación. La primera está adscrita al departamento de Bioquímica y Biología Molecular 2 de la universidad de Granada y la segunda la llevamos a cabo en el Instituto de Nutrición y Tecnología de los Alimentos “José Mataix Verdú”, situado en el Centro de Investigación Biomédica del Parque Tecnológico de Ciencias de la Salud de Granada. El grupo ha investigado activamente las funciones biológicas de los nucleótidos de la leche humana, siendo reconocido como un grupo de prestigio internacional en este campo. Hemos contribuido a aclarar el papel de estos compuestos en el metabolismo de los ácidos grasos poliinsaturados y de las lipoproteínas durante el periodo neonatal, y en la modulación de la respuesta inmunitaria en animales de experimentación y en recién nacidos prematuros. La Unión Europea incluyó en la Directiva 96/4/CE sobre preparados para lactantes un anexo que recomienda la suplementación con nucleótidos de las fórmulas infantiles (basadas en leche de vaca). A través de varios proyectos y contratos de investigación, nuestro grupo ha participado en el diseño y formulación de dietas para lactantes suplementadas con nucleótidos que se comercializan en la actualidad por la empresa Abbott Laboratories S. A, bajo la marca PULEVA. Del mismo modo, hemos investigado la función de los nucleótidos en el desarrollo y en la reparación tisular, comprobando que estos compuestos ejercen efectos reparadores sobre el intestino delgado y el hígado en modelos animales de enfermedad.
Lineas de investigación
- Evaluación clínica y experimental de alimentos funcionales
- Obesidad.
- Probióticos y microbiota intestinal.
Palabras clave
Obesidad, microbiota intestinal, probióticos, alimentos funcionales
| Miembro |
|---|
| SÁEZ LARA, MARÍA JOSÉ |
| RUIZ OJEDA, FRANCISCO JAVIER |
| PLAZA DIAZ, JULIO |
| ANGUITA RUIZ, AUGUSTO |
| FONTANA GALLEGO, LUIS |
| ALVAREZ MERCADO, ANA ISABEL |
| GIL HERNÁNDEZ, ÁNGEL |
| MESA GARCÍA, MARÍA DOLORES |
| AGUILERA GARCÍA, CONCEPCIÓN MARÍA |
| MENDEZ GUTIERREZ, ANDREA |
| GÓMEZ LLORENTE, CAROLINA |
Plaza-Díaz J, Fontana L, Gil A
Human Milk Oligosaccharides and Immune System Development.
Nutrients, 2018; 10(8);
FI: 4.171; Q1 / D3
Sanchez-Rodriguez E, Lima-Cabello E, Biel-Glesson S, Fernandez-Navarro JR, Calleja MA, Roca M, Espejo-Calvo JA, Gil-Extremera B, Soria-Florido M, de la Torre R, Fito M, Covas MI, Alche JD, Martinez de Victoria E, Gil A, Mesa MD
Effects of Virgin Olive Oils Differing in Their Bioactive Compound Contents on Metabolic Syndrome and Endothelial Functional Risk Biomarkers in Healthy Adults: A Randomized Double-Blind Controlled Trial.
Nutrients, 2018; 10(5);
FI: 4.171; Q1 / D3
Plaza-Díaz J, Ruiz-Ojeda FJ, Gil-Campos M, Gil A
Immune-Mediated Mechanisms of Action of Probiotics and Synbiotics in Treating Pediatric Intestinal Diseases.
Nutrients, 2018; 10(1);
FI: 4.171; Q1 / D3
Plaza-Díaz J, Robles-Sánchez C, Abadía-Molina F, Sáez-Lara MJ, Vilchez-Padial LM, Gil Á, Gómez-Llorente C, Fontana L
Gene expression profiling in the intestinal mucosa of obese rats administered probiotic bacteria.
Scientific data, 2017; 4; 170186
FI: 5.311; Q1 / D2
Pozo OJ, Pujadas M, Gleeson SB, Mesa-García MD, Pastor A, Kotronoulas A, Fitó M, Covas MI, Navarro JRF, Espejo JA, Sanchez-Rodriguez E, Marchal R, Calleja MA, de la Torre R
Liquid chromatography tandem mass spectrometric determination of triterpenes in human fluids: Evaluation of markers of dietary intake of olive oil and metabolic disposition of oleanolic acid and maslinic acid in humans.
Analytica chimica acta, 2017; 990; 84-95
FI: 5.123; Q1 / D1
Gonzalez-Anton C, Artacho R, Ruiz-Lopez MD, Gil A, Mesa MD
Modification of appetite by bread consumption: A systematic review of randomized controlled trials.
Critical reviews in food science and nutrition, 2017; 57(14); 3035-3050
FI: 6.015; Q1 / D1
Olza J, Aranceta-Bartrina J, González-Gross M, Ortega RM, Serra-Majem L, Varela-Moreiras G, Gil Á
Reported Dietary Intake and Food Sources of Zinc, Selenium, and Vitamins A, E and C in the Spanish Population: Findings from the ANIBES Study.
Nutrients, 2017; 9(7);
FI: 4.196; Q1 / D2
Pérez-Rodrigo C, Gianzo-Citores M, Gil Á, González-Gross M, Ortega RM, Serra-Majem L, Varela-Moreiras G, Aranceta-Bartrina J
Lifestyle Patterns and Weight Status in Spanish Adults: The ANIBES Study.
Nutrients, 2017; 9(6);
FI: 4.196; Q1 / D2
Plaza-Díaz J, Robles-Sánchez C, Abadía-Molina F, Morón-Calvente V, Sáez-Lara MJ, Ruiz-Bravo A, Jiménez-Valera M, Gil Á, Gómez-Llorente C, Fontana L
Adamdec1, Ednrb and Ptgs1/Cox1, inflammation genes upregulated in the intestinal mucosa of obese rats, are downregulated by three probiotic strains.
Scientific reports, 2017; 7(1); 1939
FI: 4.122; Q1 / D2
Pastor-Villaescusa, B; Diaz, JP; Aguilera, CM
RE: Statistical Interpretation Error in Metformin Trial Article Response
PEDIATRICS, 2017; 140;
FI: 5.515; Q1 / D1
Pastor-Villaescusa, B; Canete, MD; Caballero-Villarraso, J; Hoyos, R; Latorre, M; Vazquez-Cobela, R; Plaza-Diaz, J; Maldonado, J; Bueno, G; Leis, R; Gil, A; Canete, R; Aguilera, CM
Metformin for Obesity in Prepubertal and Pubertal Children: A Randomized Controlled Trial
PEDIATRICS, 2017; 140;
FI: 5.515; Q1 / D1
Plaza-Diaz, J; Ruiz-Ojeda, FJ; Vilchez-Padial, LM; Gil, A
Evidence of the Anti-Inflammatory Effects of Probiotics and Synbiotics in Intestinal Chronic Diseases
NUTRIENTS, 2017; 9;
FI: 4.196; Q1 / D2
Rangel-Huerta, OD; Aguilera, CM; Perez-de-la-Cruz, A; Vallejo, F; Tomas-Barberan, F; Gil, A; Mesa, MD
A serum metabolomics-driven approach predicts orange juice consumption and its impact on oxidative stress and inflammation in subjects from the BIONAOS study
MOLECULAR NUTRITION & FOOD RESEARCH, 2017; 61;
FI: 5.151; Q1 / D1
Gonzalez-Rodriguez, LG; Sanchez, JMP; Aranceta-Bartrina, J; Gil, A; Gonzalez-Gross, M; Serra-Majem, L; Varela-Moreiras, G; Ortega, RM
Intake and Dietary Food Sources of Fibre in Spain: Differences with Regard to the Prevalence of Excess Body Weight and Abdominal Obesity in Adults of the ANIBES Study
NUTRIENTS, 2017; 9;
FI: 4.196; Q1 / D2
Ruiz, E; Rodriguez, P; Valero, T; Avila, JM; Aranceta-Bartrina, J; Gil, A; Gonzalez-Gross, M; Ortega, RM; Serra-Majem, L; Varela-Moreiras, G
Dietary Intake of Individual (Free and Intrinsic) Sugars and Food Sources in the Spanish Population: Findings from the ANIBES Study
NUTRIENTS, 2017; 9;
FI: 4.196; Q1 / D2
Casuso RA, Plaza-Díaz J, Ruiz-Ojeda FJ, Aragón-Vela J, Robles-Sanchez C, Nordsborg NB, Hebberecht M, Salmeron LM, Huertas JR
High-intensity high-volume swimming induces more robust signaling through PGC-1α and AMPK activation than sprint interval swimming in m. triceps brachii.
PloS one, 2017; 12(10); e0185494
FI: 2.766; Q1 / D3
Navia B, López-Sobaler AM, Villalobos T, Aranceta-Bartrina J, Gil Á, González-Gross M, Serra-Majem L, Varela-Moreiras G, Ortega RM
Breakfast habits and differences regarding abdominal obesity in a cross-sectional study in Spanish adults: The ANIBES study.
PloS one, 2017; 12(11); e0188828
FI: 2.766; Q1 / D3
Partearroyo T, Samaniego-Vaesken ML, Ruiz E, Olza J, Aranceta-Bartrina J, Gil Á, González-Gross M, Ortega RM, Serra-Majem L, Varela-Moreiras G
Dietary sources and intakes of folates and vitamin B12 in the Spanish population: Findings from the ANIBES study.
PloS one, 2017; 12(12); e0189230
FI: 2.766; Q1 / D3
Biel S, Mesa MD, de la Torre R, Espejo JA, Fernández-Navarro JR, Fitó M, Sánchez-Rodriguez E, Rosa C, Marchal R, Alche JD, Expósito M, Brenes M, Gandul B, Calleja MA, Covas MI
The NUTRAOLEOUM Study, a randomized controlled trial, for achieving nutritional added value for olive oils.
BMC complementary and alternative medicine, 2016; 16(1); 404
FI: 2.288; Q1 / D2
Soto-Méndez MJ, Aguilera CM, Mesa MD, Campaña-Martín L, Martín-Laguna V, Solomons NW, Schümann K, Gil Á
Interaction of Giardia intestinalis and Systemic Oxidation in Preschool Children in the Western Highlands of Guatemala.
Journal of pediatric gastroenterology and nutrition, 2016; 63(1); 118-22
FI: 2.799; Q1 / D2
Martínez-Victoria E, Gil A, Charrondiere UR
Preface.
Food chemistry, 2016; 193; 1
FI: 4.529; Q1 / D1
Fernandez-Gomez, B; Lezama, A; Amigo-Benavent, M; Ullate, M; Herrero, M; Martin, MA; Mesa, MD; del Castillo, MD
Insights on the health benefits of the bioactive compounds of coffee silverskin extract
JOURNAL OF FUNCTIONAL FOODS, 2016; 25;
FI: 3.144; Q1 / D2
Fernandez-Gomez, B; Ramos, S; Goya, L; Mesa, MD; del Castillo, MD; Martin, MA
Coffee silverskin extract improves glucose-stimulated insulin secretion and protects against streptozotocin-induced damage in pancreatic INS-1E beta cells
FOOD RESEARCH INTERNATIONAL, 2016; 89;
FI: 3.086; Q1 / D2
López-Sobaler AM, Rodríguez-Rodríguez E, Aranceta-Bartrina J, Gil Á, González-Gross M, Serra-Majem L, Varela-Moreiras G, Ortega RM
General and Abdominal Obesity Is Related to Physical Activity, Smoking and Sleeping Behaviours and Mediated by the Educational Level: Findings from the ANIBES Study in Spain.
PloS one, 2016; 11(12); e0169027
FI: 2.806; Q1 / D3
Ruiz-Ojeda FJ, Gomez-Llorente C, Aguilera CM, Gil A, Rupérez AI
Impact of 3-Amino-1,2,4-Triazole (3-AT)-Derived Increase in Hydrogen Peroxide Levels on Inflammation and Metabolism in Human Differentiated Adipocytes.
PloS one, 2016; 11(3); e0152550
FI: 2.806; Q1 / D3
Mielgo-Ayuso J, Aparicio-Ugarriza R, Castillo A, Ruiz E, Ávila JM, Aranceta-Batrina J, Gil Á, Ortega RM, Serra-Majem L, Varela-Moreiras G, González-Gross M
Physical Activity Patterns of the Spanish Population Are Mostly Determined by Sex and Age: Findings in the ANIBES Study.
PloS one, 2016; 11(2); e0149969
FI: 2.806; Q1 / D3
Soto-Méndez MJ, Aguilera CM, Mesa MD, Campaña-Martín L, Martín-Laguna V, Solomons NW, Schümann K, Gil Á
Correction: Strong Associations Exist among Oxidative Stress and Antioxidant Biomarkers in the Circulating, Cellular and Urinary Anatomical Compartments in Guatemalan Children from the Western Highlands.
PloS one, 2016; 11(2); e0149740
FI: 2.806; Q1 / D3
Soto-Méndez MJ, Aguilera CM, Mesa MD, Campaña-Martín L, Martín-Laguna V, Solomons NW, Schümann K, Gil Á
Strong Associations Exist among Oxidative Stress and Antioxidant Biomarkers in the Circulating, Cellular and Urinary Anatomical Compartments in Guatemalan Children from the Western Highlands.
PloS one, 2016; 11(1); e0146921
FI: 2.806; Q1 / D3
Catena A, Muñoz-Machicao JA, Torres-Espínola FJ, Martínez-Zaldívar C, Diaz-Piedra C, Gil A, Haile G, Györei E, Molloy AM, Decsi T, Koletzko B, Campoy C
Folate and long-chain polyunsaturated fatty acid supplementation during pregnancy has long-term effects on the attention system of 8.5-y-old offspring: a randomized controlled trial.
The American journal of clinical nutrition, 2016; 103(1); 115-27
FI: 6.926; Q1 / D1
Soto-Méndez MJ, Aguilera CM, Campaña-Martín L, Martín-Laguna V, Schümann K, Solomons NW, Gil A
Variation in hydration status within the normative range is associated with urinary biomarkers of systemic oxidative stress in Guatemalan preschool children.
The American journal of clinical nutrition, 2015; 102(4); 865-72
FI: 6.703; Q1 / D1
Baena-Gómez MA, Aguilar MJ, Mesa MD, Navero JL, Gil-Campos M
Changes in Antioxidant Defense System Using Different Lipid Emulsions in Parenteral Nutrition in Children after Hematopoietic Stem Cell Transplantation.
Nutrients, 2015; 7(9); 7242-55
FI: 3.759; Q1 / D2
Rangel-Huerta OD, Aguilera CM, Martin MV, Soto MJ, Rico MC, Vallejo F, Tomas-Barberan F, Perez-de-la-Cruz AJ, Gil A, Mesa MD
Normal or High Polyphenol Concentration in Orange Juice Affects Antioxidant Activity, Blood Pressure, and Body Weight in Obese or Overweight Adults.
The Journal of nutrition, 2015; 145(8); 1808-16
FI: 3.74; Q1 / D3
Ruiz JR, Martinez-Tellez B, Sanchez-Delgado G, Aguilera CM, Gil A
Regulation of energy balance by brown adipose tissue: at least three potential roles for physical activity.
British journal of sports medicine, 2015; 49(15); 972-3
FI: 6.724; Q1 / D1
de la Paz-Gallardo MJ, García FS, de Haro-Muñoz T, Padilla-Vinuesa MC, Zafra-Ceres M, Gomez-Capilla JA, Gomez-Llorente C
Quantitative-fluorescent-PCR versus full karyotyping in prenatal diagnosis of common chromosome aneuploidies in southern Spain.
Clinical chemistry and laboratory medicine, 2015; 53(9); 1333-8
FI: 3.017; Q1 / D2
Rangel-Huerta OD, Pastor-Villaescusa B, Aguilera CM, Gil A
A Systematic Review of the Efficacy of Bioactive Compounds in Cardiovascular Disease: Phenolic Compounds.
Nutrients, 2015; 7(7); 5177-216
FI: 3.759; Q1 / D2
Ruiz E, Ávila JM, Valero T, del Pozo S, Rodriguez P, Aranceta-Bartrina J, Gil Á, González-Gross M, Ortega RM, Serra-Majem L, Varela-Moreiras G
Energy Intake, Profile, and Dietary Sources in the Spanish Population: Findings of the ANIBES Study.
Nutrients, 2015; 7(6); 4739-62
FI: 3.759; Q1 / D2
Fernandez-Gomez B, Ullate M, Picariello G, Ferranti P, Mesa MD, del Castillo MD
New knowledge on the antiglycoxidative mechanism of chlorogenic acid.
Food & function, 2015; 6(6); 2081-90
FI: 2.686; Q1 / D2
Gonzalez-Anton C, Rico MC, Sanchez-Rodriguez E, Ruiz-Lopez MD, Gil A, Mesa MD
Glycemic responses, appetite ratings and gastrointestinal hormone responses of most common breads consumed in Spain. A randomized control trial in healthy humans.
Nutrients, 2015; 7(6); 4033-53
FI: 3.759; Q1 / D2
Plaza-Díaz J, Fernández-Caballero JÁ, Chueca N, García F, Gómez-Llorente C, Sáez-Lara MJ, Fontana L, Gil Á
Pyrosequencing analysis reveals changes in intestinal microbiota of healthy adults who received a daily dose of immunomodulatory probiotic strains.
Nutrients, 2015; 7(6); 3999-4015
FI: 3.759; Q1 / D2
Scott JA, Kwok YY, Synnott K, Bogue J, Amarri S, Norin E, Gil A, Edwards CA, Other Members of the INFABIO Project Team
A comparison of maternal attitudes to breastfeeding in public and the association with breastfeeding duration in four European countries: results of a cohort study.
Birth (Berkeley, Calif.), 2015; 42(1); 78-85
FI: 1.867; Q1 / D1
Ruiz E, Ávila JM, Castillo A, Valero T, del Pozo S, Rodriguez P, Bartrina JA, Gil Á, González-Gross M, Ortega RM, Serra-Majem L, Varela-Moreiras G
The ANIBES Study on Energy Balance in Spain: design, protocol and methodology.
Nutrients, 2015; 7(2); 970-98
FI: 3.759; Q1 / D2
Gonzalez-Anton C, Lopez-Millan B, Rico MC, Sanchez-Rodriguez E, Ruiz-Lopez MD, Gil A, Mesa MD
An enriched, cereal-based bread affects appetite ratings and glycemic, insulinemic, and gastrointestinal hormone responses in healthy adults in a randomized, controlled trial.
The Journal of nutrition, 2015; 145(2); 231-8
FI: 3.74; Q1 / D3
Soto-Méndez MJ, Romero-Abal ME, Aguilera CM, Rico MC, Solomons NW, Schümann K, Gil A
Associations among Inflammatory Biomarkers in the Circulating, Plasmatic, Salivary and Intraluminal Anatomical Compartments in Apparently Healthy Preschool Children from the Western Highlands of Guatemala.
PloS one, 2015; 10(6); e0129158
FI: 3.057; Q1 / D2
Plaza-Diaz J, Gomez-Llorente C, Abadia-Molina F, Saez-Lara MJ, Campaña-Martin L, Muñoz-Quezada S, Romero F, Gil A, Fontana L
Effects of Lactobacillus paracasei CNCM I-4034, Bifidobacterium breve CNCM I-4035 and Lactobacillus rhamnosus CNCM I-4036 on hepatic steatosis in Zucker rats.
PLoS One, 2014; 9; e98401
FI: 3.234; Q1 / D2
Gomez-Llorente C, Plaza-Diaz J, Aguilera M, Muñoz-Quezada S, Bermudez-Brito M, Peso-Echarri P, Martinez-Silla R, Vasallo-Morillas MI, Campaña-Martin L, Vives-Piñera I, Ballesta-Martinez MJ, Gil A
Three main factors define changes in fecal microbiota associated with feeding modality in infants.
Journal of pediatric gastroenterology and nutrition, 2013; 57(4); 461-6
FI: 2.873; Q1 / D2
Plaza-Diaz J, Gomez-Llorente C, Campaña-Martin L, Matencio E, Ortuño I, Martínez-Silla R, Gomez-Gallego C, Periago MJ, Ros G, Chenoll E, Genovés S, Casinos B, Silva A, Corella D, Portolés O, Romero F, Ramón D, Perez de la Cruz A, Gil A, Fontana L
Safety and immunomodulatory effects of three probiotic strains isolated from the feces of breast-fed infants in healthy adults: SETOPROB study.
PloS one, 2013; 8(10); e78111
FI: 3.534; Q1 / D2
Título del proyecto: MV19/00062 - AUGUSTO ANGUITA RUIZ
Financiador: INSTITUTO DE SALUD CARLOS III
Nº Expediente: MV19/00062
Ejecución: 2020-2020
IP: AUGUSTO ANGUITA RUIZ
Título del proyecto: ESTUDIO EPIDEMIOLÓGICO DE LA MICROBIOTA DE NIÑOS CRÍTICAMENTE ENFERMOS Y SU RELACIÓN CON EL DESARROLLO DE COMPLICACIONES Y BIOMARCADORES DE INFLAMACIÓN
Financiador: INSTITUTO DE SALUD CARLOS III
Nº Expediente: PI18/01334
Ejecución: 2019-2021
IP: MARÍA DOLORES MESA GARCÍA
Título del proyecto: Microbiota Mamaria E Intestinal y Su Relación Con el Cáncer de Mama
Financiador: CONSEJERIA DE SALUD
Nº Expediente: PI-0538-2017
Ejecución: 2018-2020
IP: LUIS FONTANA GALLEGO
Título del proyecto: Estudio de la microbiota fetal y materna en gestaciones con defecto del crecimiento fetal y su relación con biomarcadores de inflamación. BIOCIR.
Financiador: INSTITUTO DE SALUD CARLOS III
Nº Expediente: PI17/01215
Ejecución: 2018-2020
IP: CAROLINA GOMEZ LLORENTE
Título del proyecto: PI16/00871 - CONCEPCION AGUILERA - PUBERTAD Y RIESGO METABÓLICO EN NIÑOS OBESOS: ALTERACIONES EPIGENÉTICAS E IMPLICACIONES FISIOPATOLÓGICAS Y DIAGNÓSTICAS. Estudio PUBMEP
Financiador: INSTITUTO DE SALUD CARLOS III
Nº Expediente: PI16/00871
Ejecución: 2017-2019
IP: CONCEPCIÓN AGUILERA GARCÍA
Título del proyecto: PI-0373-2014 - Influencia de la Microbiota Intestinal y de Biomarcadores de Inflamación en el Desarrollo Temprano del Asma en Niños Obesos Prepúberes (Bioasma)
Financiador: FUNDACION PUBLICA ANDALUZA PROGRESO Y SALUD
Nº Expediente: PI-0373-2014
Ejecución: 2015-2018
IP: CAROLINA GOMEZ LLORENTE
