MP20-Biomarcadores de Enfermedades Metabólicas y Óseas

Información
Miembros
Publicaciones
Proyectos
Ensayos clínicos

El grupo de Biomarcadores de Enfermedades Metabólicas y Oseas se dedica fundamentalmente a la identificación de biomarcadores y nuevas dianas terapéuticas en patologías prevalentes.

Líneas de investigación

Desarrollo de nuevos kits de diagnóstico en colaboración con empresas biotecnológicas.
Ensayos clínicos de medicamentos antiosteoporóticos y antidiabéticos.
Estudio de la aplicación de nuevas técnicas no invasivas (Trabecular Bone Score y 3D Shaper) para la evaluación de la micro y macro arquitectura ósea y el diagnóstico precoz de la fragilidad ósea.
Estudio del papel del hueso y músculo como órganos endocrinos y del efecto de los fármacos antiosteoporóticos en el metabolismo energético y el sistema vascular.
Identificación de potenciales moléculas inhibidoras de vías metabólicas implicadas en complicaciones vasculares en pacientes con DMT2 mediante el uso de herramientas bioinformáticas (molecular docking y técnicas de biología estructural)
Influencias genéticas, hormonales y nutricionales en la fragilidad ósea
Interacción entre fragilidad ósea, diabetes mellitus y enfermedad cardiovascular como enfermedades ligadas al envejecimiento.

Redes de investigación

CIBERFES - Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable
CIBEROBN - Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición

Palabras clave

Diabetes tipo 2, osteoporosis, fragilidad ósea, enfermedad cardiovascular, biomarcadores, dianas terapéuticas

VICTORIA CONTRERAS BOLIVAR

SILVIA LOZANO ALONSO

ENRIQUE MORATALLA ARANDA

MANUEL EDUARDO MUÑOZ TORRES

MANUEL MUÑOZ GARACH

CRISTINA NOVO RODRIGUEZ

REBECA REYES GARCÍA

JUAN MIGUEL VILLA SUAREZ

CARMEN YESTE DOBLAS

VERONICA AVILA RUBIO

MARIA DOLORES AVILES PEREZ

ORCID

MARIA LUISA FERNANDEZ SOTO

BEATRIZ GARCIA FONTANA

ORCID

ANTONIA GARCIA MARTIN

CRISTINA GARCIA FONTANA

ORCID

SHEILA GONZALEZ SALVATIERRA

ORCID

PABLO JOSE LOPEZ-IBARRA LOZANO

Osuna-Prieto, FJ; Martinez-Tellez, B; Segura-Carretero, A; Ruiz, JR

Activation of Brown Adipose Tissue and Promotion ofWhite Adipose Tissue Browning by Plant-based Dietary Components in Rodents: A Systematic Review

ADVANCES IN NUTRITION, 2021;

FI:8,701; D1

Gracia-Marco, L; Gonzalez-Salvatierra, S; Garcia-Martin, A; Ubago-Guisado, E; Garcia-Fontana, B; Gil-Cosano, JJ; Munoz-Torres, M

3D DXA Hip Differences in Patients with Acromegaly or Adult Growth Hormone Deficiency

JOURNAL OF CLINICAL MEDICINE, 2021;

FI:4,242; Q1

Dote-Montero, M; Carneiro-Barrera, A; Martinez-Vizcaino, V; Ruiz, JR; Amaro-Gahete, FJ

Acute effect of HIIT on testosterone and cortisol levels in healthy individuals: A systematic review and meta-analysis

SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS, 2021;

FI:4,221; Q1

Sanabria-de la Torre, R; Quinones-Vico, MI; Fernandez-Gonzalez, A; Sanchez-Diaz, M; Montero-Vilchez, T; Sierra-Sanchez, A; Arias-Santiago, S

Alloreactive Immune Response Associated to Human Mesenchymal Stromal Cells Treatment: A Systematic Review

JOURNAL OF CLINICAL MEDICINE, 2021;

FI:4,242; Q1

Paz-Graniel, I; Babio, N; Becerra-Tomas, N; Toledo, E; Camacho-Barcia, L; Corella, D; Castaner-Nino, O; Romaguera, D; Vioque, J; Alonso-Gomez, AM; Warnberg, J; Martinez, JA; Serra-Majem, L; Estruch, R; Tinahones, FJ; Fernandez-Aranda, F; Lapetra, J; Pinto

Association between coffee consumption and total dietary caffeine intake with cognitive functioning: cross-sectional assessment in an elderly Mediterranean population

EUROPEAN JOURNAL OF NUTRITION, 2021;

FI:5,619; Q1

Cano-Ibanez, N; Gea, A; Ruiz-Canela, M; Corella, D; Salas-Salvado, J; Schroder, H; Navarrete-Munoz, EM; Romaguera, D; Martinez, JA; Baron-Lopez, FJ; Lopez-Miranda, J; Estruch, R; Riquelme-Gallego, B; Alonso-Gomez, A; Tur, JA; Tinahones, FJ; Serra-Majem, L

Diet quality and nutrient density in subjects with metabolic syndrome: Influence of socioeconomic status and lifestyle factors. A cross-sectional assessment in the PREDIMED-Plus study

CLINICAL NUTRITION, 2020;

FI:6,36; D1

Gracia-Marco, L; Garcia-Fontana, B; Ubago-Guisado, E; Vlachopoulos, D; Garcia-Martin, A; Munoz-Torres, M

Analysis of Bone Impairment by 3D DXA Hip Measures in Patients With Primary Hyperparathyroidism: A Pilot Study

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2020;

FI:5,399; Q1

Riquelme-Gallego, B; Garcia-Molina, L; Cano-Ibanez, N; Sanchez-Delgado, G; Andujar-Vera, F; Garcia-Fontana, C; Gonzalez-Salvatierra, S; Garcia-Recio, E; Martinez-Ruiz, V; Bueno-Cavanillas, A; Munoz-Torres, M; Garcia-Fontana, B

Circulating Undercarboxylated Osteocalcin as Estimator of Cardiovascular and Type 2 Diabetes Risk in Metabolic Syndrome Patients

SCIENTIFIC REPORTS, 2020;

FI:3,998; Q1

Molina-Leyva, I; Molina-Leyva, A; Riquelme-Gallego, B; Cano-Ibanez, N; Garcia-Molina, L; Bueno-Cavanillas, A

Effectiveness of Mediterranean Diet Implementation in Dry Eye Parameters: A Study of PREDIMED-PLUS Trial

NUTRIENTS, 2020;

FI:4,546; Q1

Andujar-Vera, F; Garcia-Fontana, C; Lozano-Alonso, S; Gonzalez-Salvatierra, S; Iglesias-Baena, I; Munoz-Torres, M; Garcia-Fontana, B

Association between oxidative-stress-related markers and calcified femoral artery in type 2 diabetes patients

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2020;

FI:3,209; Q2

Perkovic, V; Jardine, MJ; Neal, B; Bompoint, S; Heerspink, HJL; Charytan, DM; Edwards, R; Agarwal, R; Bakris, G; Bull, S; Cannon, CP; Capuano, G; Chu, PL; De Zeeuw, D; Greene, T; Levin, A; Pollock, C; Wheeler, DC; Yavin, Y; Zhang, H; Zinman, B; Meininger, G; Brenner, BM; Mahaffey, KW; McGuire, DK; Holman, R; Home, P; Scharfstein, D; Parfrey, P; Shahinfar, S; August, P; Chang, T; Sinha, AD; Januzzi, J; Kolansky, D; Amerena, J; Hillis, G; Gorelick, P; Kissela, B; Kasner, S; Lindley, R; Fulcher, G; Ounadjela, S; Hufert, K; von Ingersleben, G; Gaglia, J; Harris, R; Hudson, M; Turchin, A; Cheifetz, A; Sheth, S; Feuerstein, J; Cohen, S; Li, N; Kolesnyk, I; Aizenberg, D; Pecoits, R; Cherney, D; Obrador, G; Chertow, G; Hawley, C; Ji, LN; Wada, T; Jha, V; Lim, SK; Lim-Abrahan, MA; Santos, F; Chae, DW; Hwang, SJ; Vazelov, E; Rychlik, I; Hadjadj, S; Krane, V; Rosivall, L; De Nicola, L; Dreval, A; Nowicki, M; Schiller, A; Distiller, L; Gorriz, JL; Kolesnyk, M; Morren, F; Goykhman, S; David, C; Yost, L; Wang, H; Hettiarachchi, M; Thimmaiah, R; Koppolu, D; George, S; Schmidt, M; Ignjatovic, J; Chapin, L; Travis, K; Destree, M; Sood, V; Coffee, L; De Brouwer, K; Zaviriukha, V; Starzec, A; Koizumi, M; Lin, G; Chen, E; Lin, P; Leia, C; Mascaro, D; Amigo, A; Limos, A; Abrahamsen, I; Jaffer, S; Guerrero, RAA; Aizenberg, D; Albisu, JP; Alvarisqueta, A; Bartolacci, I; Berli, MA; Bordonava, A; Calella, P; Cantero, MC; Cartasegna, LR; Cercos, E; Coloma, GC; Colombo, H; Commendatore, V; Cuadrado, J; Cuneo, CA; Cusumano, AM; Douthat, WG; Dran, RD; Farias, E; Fernandez, MF; Finkelstein, H; Fragale, G; Fretes, JO; Garcia, NH; Gastaldi, A; Gelersztein, E; Glenny, JA; Gonzalez, JP; Colaso, PDG; Goycoa, C; Greloni, GC; Guinsburg, A; Hermida, S; Juncos, LI; Klyver, MI; Kraft, F; Krynski, F; Lanchiotti, PV; de la Fuente, RAL; Marchetta, N; Mele, P; Nicolai, S; Novoa, PA; Orio, SI; Otreras, F; Oviedo, A; Raffaele, P; Resk, JH; Rista, L; Papini, NR; Sala, J; Santos, JC; Schiavi, LB; Sessa, H; Casabella, TS; Ulla, MR; Valdez, M; Vallejos, A; Villarino, A; Visco, VE; Wassermann, A; Zaidman, CJ; Cheung, NW; Droste, C; Fraser, I; Johnson, D; Mah, PM; Nicholls, K; Packham, D; Proietto, J; Roberts, A; Roger, S; Tsang, V; Raduan, RA; da Costa, FAA; Amodeo, C; Turatti, LAA; Bregman, R; Sanches, FCC; Canani, LH; Chacra, AR; Borges, JLC; Vencio, SAC; Franco, RJD; d'Avila, D; Portes, ED; de Souza, P; Deboni, LM; Fraige, F; Neto, BG; Gomes, M; Kohara, SK; Keitel, E; Saraiva, JFK; Lisboa, HRK; Contieri, FLD; Milagres, R; Montenegro, R; de Brito, CM; Hissa, MN; Sabbag, ARN; Noronha, I; Panarotto, D; Pecoits, R; Pereira, MA; Saporito, W; Scotton, AS; Schuch, T; de Almeida, RS; Ramos, CS; Felicio, JS; Thome, F; Hachmann, JCT; Yamada, S; Hayashida, CY; Petry, TBZ; Zanella, MT; Andreeva, V; Angelova, A; Dimitrov, S; Genadieva, V; Genova-Hristova, G; Hristozov, K; Kamenov, Z; Koundurdjiev, A; Lozanov, L; Margaritov, V; Nonchev, B; Rangelov, R; Shinkov, A; Temelkova, M; Velichkova, E; Yakov, A; Aggarwal, N; Aronson, R; Bajaj, H; Cherney, D; Chouinard, G; Conway, J; Cournoyer, S; DaRoza, G; De Serres, S; Dube, F; Goldenberg, R; Gupta, A; Gupta, M; Henein, S; Khandwala, H; Leiter, L; Madore, F; McMahon, A; Muirhead, N; Pichette, V; Rabasa-Lhoret, R; Steele, A; Tangri, N; Torshizi, A; Woo, V; Zalunardo, N; Montenegro, MAF; Jorquera, JGG; Farina, MM; Gajardo, VS; Vejar, M; Chen, N; Chen, QK; Gan, SL; Kong, YZ; Li, DT; Li, WG; Li, XM; Lin, HL; Liu, J; Lu, WP; Mao, H; Ren, Y; Song, WH; Sun, J; Sun, L; Tu, P; Wang, GX; Yang, JK; Yin, AP; Yu, XQ; Zhao, MH; Zheng, HG; Mendoza, JLA; Arcos, E; Avendano, J; Ruiz, JEAD; Ortiz, LHG; Gonzalez, A; Triana, EH; Higuera, JD; Malaver, N; de Salazar, DIM; Rosero, R; Lozano, MAT; Cometa, LV; Valenzuela, A; Alonso, RDV; Villegas, I; Yupanqui, H; Bartaskova, D; Barton, P; Belobradkova, J; Dohnalova, L; Drasnar, T; Ferkl, R; Halciakova, K; Klokocnikova, V; Kovar, R; Lastuvka, J; Lukac, M; Pesickova, S; Peterka, K; Pumprla, J; Rychlik, I; Saudek, F; Tesar, V; Valis, M; Weiner, P; Zemek, S; Alamartine, E; Borot, S; Cariou, B; Dussol, B; Fauvel, JP; Gourdy, P; Klein, A; Le Meur, Y; Penfornis, A; Roussel, R; Saulnier, PJ; Thervet, E; Zaoui, P; Burst, V; Faghih, M; Faulmann, G; Haller, H; Jerwan-Keim, R; Maxeiner, S; Paschen, B; Plassmann, G; Rose, L; Orellana, RAG; Haase, FP; Diaz, JPM; Roca, LAR; Arenales, JAS; Polo, JVS; Juarez, ET; Csecsei, G; Csiky, B; Danos, P; Deak, L; Dudas, M; Harcsa, E; Keltai, K; Keresztesi, S; Kiss, K; Konyves, L; Major, L; Mileder, M; Molnar, M; Mucsi, J; Oroszlan, T; Ory, I; Paragh, G; Peterfai, E; Petro, G; Revesz, K; Takacs, R; Vangel, S; Vasas, S; Zsom, M; Abraham, O; Bhushan, R; Deepak, D; Edwin, FM; Gopalakrishnan, N; Gracious, N; Hansraj, A; Jain, D; Keshavamurthy, CB; Khullar, D; Manisha, S; Peringat, J; Prasad, N; Satyanarayana, RK; Sreedhar, R; Sreelatha, M; Sudhakar, B; Vyasam, RC; Bonadonna, R; Castellino, P; Ceriello, A; Chiovato, L; De Cosmo, S; De Nicola, L; Derosa, G; Di Carlo, A; Di Cianni, G; Frasca, G; Fuiano, G; Gambaro, G; Garibotto, G; Giorda, C; Malberti, F; Mandreoli, M; Mannucci, E; Orsi, E; Piatti, P; Santoro, D; Sasso, FC; Serviddio, G; Stella, A; Trevisan, R; Veronelli, AM; Zanoli, L; Akiyama, H; Aoki, H; Asano, A; Iitsuka, T; Kajiyama, S; Kashine, S; Kawada, T; Kodera, T; Kono, H; Koyama, K; Kumeda, Y; Miyauchi, S; Mizuyama, K; Niiya, T; Oishi, H; Ota, S; Sakakibara, T; Takai, M; Tomonaga, O; Tsujimoto, M; Wada, T; Wakasugi, M; Wakida, Y; Watanabe, T; Yamada, M; Yanagida, K; Yanase, T; Yumita, W; Gaupsiene, E; Kozloviene, D; Navickas, A; Urbanaviciene, E; Ghani, RA; Kadir, KA; Ali, N; Yusof, MDC; Gan, CL; Ismail, M; Kong, WY; Lam, SW; Lee, LY; Lim, SK; Loh, CL; Manocha, AB; Ng, KS; Ahmad, NNFN; Ratnasingam, V; Bin Shudim, SS; Vengadasalam, P; Munoz, LDA; Salazar, MA; Cruz, JB; Soto, MB; Ramos, JC; Wong, AC; Rotter, JRC; Escalante, TD; Sosa, FEE; Lozano, FF; Cervera, LFF; Baron, PF; Ballesteros, CG; Rangel, JDG; Jimenez, LEH; Santana, SSI; Flores, FJ; Molina, HL; Ceballos, RIL; Blanco, BMD; Franco, GM; Loza, OTM; Rocha, CM; Vera, GO; Castellanos, RO; Calcaneo, JP; Rosano, MAR; Pattzi, HR; Guzman, JR; Joerg, IER; Sanchez, SBS; Mijangos, JHS; Sanson, PS; Orozco, JATY; Chavez, ET; Cepeda, AV; Carrillo, LV; Mesa, JV; Escobedo, RZ; Baker, J; Noonan, P; Scott, R; Walker, R; Watson, E; Williams, M; Young, S; Abejuela, Z; Agra, J; Aquitania, G; Caringal, C; Comia, RS; Delos Santos, L; Gomez, O; Jimeno, C; Tan, G; Tolentino, M; Yao, C; Yap, YE; Ygpuara, MDL; Bijata-Bronisz, R; Hotlos, L; Januszewicz, A; Kaczmarek, B; Kaminska, A; Lazuka, L; Madej, A; Mazur, S; Mlodawska-Choluj, D; Orlowska-Kowalik, G; Popenda, G; Rewerska, B; Sowinski, D; Angelescu, LM; Anghel, V; Avram, RI; Busegeanu, MM; Cif, A; Cosma, D; Crisan, C; Demian, LD; Ferariu, IE; Halmagyi, I; Hancu, N; Munteanu, M; Negru, D; Onaca, AG; Petrica, L; Popa, AR; Ranetti, AE; Serafinceanu, C; Toarba, C; Agafyina, A; Barbarash, O; Barysheva, O; Chizhov, D; Dobronravov, V; Glinkina, I; Grineva, E; Khirmanov, V; Kolmakova, E; Koroleva, T; Kvitkova, L; Marasaev, V; Mkrtumyan, A; Morugova, T; Nagibovich, G; Nagibovich, O; Nedogoda, S; Osipova, I; Raskina, T; Samoylova, Y; Sazonova, O; Shamkhalova, M; Shutemova, E; Shwartz, Y; Uriasyev, O; Vorobyev, S; Zateyshchikova, A; Zateyshshikov, D; Zykova, T; Antic, S; Djordjevic, M; Kendereski, A; Lalic, K; Lalic, N; Popovic-Radinovic, V; Babikova, J; Benusova, O; Buganova, I; Culak, J; Dzupina, A; Dzuponova, J; Fulop, P; Ilavska, A; Martinka, E; Ochodnicka, Z; Pella, D; Smatanova, I; Ahmed, F; Badat, A; Breedt, J; Distiller, L; Govender, V; Govender, R; Joshi, M; Jurgens, J; Latiff, G; Lombard, L; Mookadam, M; Ngcakani, N; Nortje, H; Oosthuizen, H; Pillay-Ramaya, L; Prozesky, H; Reddy, J; Rheeder, P; Seeber, M; Cho, YM; Jeong, IK; Kim, SG; Kim, YH; Kwon, HS; Kwon, MJ; Lee, BW; Lee, J; Lee, MK; Nam, MS; Oh, KH; Park, CY; Park, SH; Yoon, KH; Garcia, PA; Mercadal, LA; Barrios, C; Castro, FC; Guldris, SC; Lopez, MD; de los Rios, JE; Fresnedo, GF; Serrano, AG; Garcia, I; Martinez, FJG; Gimeno, JEJ; Mendoza, ML; Marin, TM; Portillo, CM; Vila, MAM; Torres, MM; Iglesias, JN; Perez, JP; Vera, MP; Perez, JMP; Simon, MAQ; Canonge, RS; Gonzalez, AS; Riera, MT; Madueno, FJT; Plaza, MV; Chang, CT; Chuang, LM; Hsia, TL; Hsieh, CH; Lin, CC; Lu, YC; Sheu, WHH; Barna, O; Bilyk, SD; Botsyurko, V; Dudar, I; Fushtey, I; Godlevska, O; Golovchenko, O; Gyrina, O; Kazmirchuk, A; Komisarenko, I; Korzh, O; Kravchun, N; Legun, O; Mankovskyy, B; Martynyuk, L; Mostovoy, Y; Pashkovska, N; Pererva, L; Pertseva, T; Samoylov, O; Smirnov, I; Svyshchenko, Y; Tomashkevych, H; Topchii, I; Tryshchuk, N; Tseluyko, V; Vizir, V; Vlasenko, M; Zlova, T; Zub, L; Abusnana, S; Railey, M; Abouglila, K; Ainsworth, P; Ali, Z; Arutchelvam, V; Barnard, M; Bellary, S; Davies, E; Davies, M; Davies, S; Dawson, A; El Kossi, M; English, P; Fraser, D; Gnudi, L; Gunstone, A; Hall, T; Hanif, W; Jackson, A; Johnson, A; Joseph, F; Krishnan, S; Kumwenda, M; MacDougall, I; Nixon, P; O'Hare, J; Philip, S; Ramtoola, S; Saxena, M; Sennik, D; Simon, G; Singh, B; Stephens, J; Strzelecka, A; Symonds, R; Turner, W; Wahba, M; Wakeling, J; Wheeler, D; Winocour, P; Abdallah, J; Abdullah, R; Abramowitz, M; Acosta, I; Aiello, J; Akright, L; Akyea-Djamson, A; Alappan, R; Alicic, R; Al-Karadsheh, A; Allison, DC; Arauz-Pacheco, C; Arfeen, S; Arif, A; Arvind, M; Atray, N; Awad, A; Barnhill, P; Barranco, E; Barrera, C; Beacom, M; Behara, V; Belo, D; Bentley-Lewis, R

Canagliflozin and Renal Outcomes in Type 2 Diabetes and Nephropathy

NEW ENGLAND JOURNAL OF MEDICINE, 2019;

FI:70,67; D1

Garcia-Fontana, C; Vilchez, JI; Gonzalez-Requena, M; Gonzalez-Lopez, J; Krell, T; Matilla, MA; Manzanera, M

The involvement of McpB chemoreceptor from Pseudomonas aeruginosa PAO1 in virulence

SCIENTIFIC REPORTS, 2019;

FI:4,011; Q1

Garcia-Fontana, C; Villa-Suarez, JM; Andujar-Vera, F; Gonzalez-Salvatierra, S; Martinez-Navajas, G; Real, PJ; Vida, JMG; de Haro, T; Garcia-Fontana, B; Munoz-Torres, M

Epidemiological, Clinical and Genetic Study of Hypophosphatasia in A Spanish Population: Identification of Two Novel Mutations in The Alpl Gene

SCIENTIFIC REPORTS, 2019;

FI:4,011; Q1

Munoz-Garach, A; Garcia-Fontana, B; Munoz-Torres, M

Vitamin D Status, Calcium Intake and Risk of Developing Type 2 Diabetes: An Unresolved Issue

NUTRIENTS, 2019;

FI:4,171; Q1

Reyes-Garcia, R; Garcia-Martin, A; Palacios, S; Salas, N; Mendoza, N; Quesada-Charneco, M; Fonolla, J; Lara-Villoslada, F; Manoz-Torres, M

Factors Predicting the Response to a Vitamin D-Fortified Milk in Healthy Postmenopausal Women

NUTRIENTS, 2019;

FI:4,171; Q1

Reyes-Garcia, R; Mendoza, N; Palacios, S; Salas, N; Quesada-Charneco, M; Garcia-Martin, A; Fonolla, J; Lara-Villoslada, F; Munoz-Torres, M

Effects of Daily Intake of Calcium and Vitamin D-Enriched Milk in Healthy Postmenopausal Women: A Randomized, Controlled, Double-Blind Nutritional Study

JOURNAL OF WOMENS HEALTH, 2018;

FI:2,097; D1

Avila-Rubio, V; Garcia-Fontana, B; Novo-Rodriguez, C; Cantero-Hinojosa, J; Reyes-Garcia, R; Munoz-Torres, M

Higher Levels of Serum 25-Hydroxyvitamin D Are Related to Improved Glucose Homeostasis in Women with Postmenopausal Osteoporosis

JOURNAL OF WOMENS HEALTH, 2018;

FI:2,097; D1

Novo-Rodriguez, C; Garcia-Fontana, B; Luna-Del Castillo, JD; Andujar-Vera, F; Avila-Rubio, V; Garcia-Fontana, C; Morales-Santana, S; Rozas-Moreno, P; Munoz-Torres, M

Circulating levels of sclerostin are associated with cardiovascular mortality

PLOS ONE, 2018;

FI:2,766; Q1

Mtibaa, R; Olicon-Hernandez, DR; Pozo, C; Nasri, M; Mechichi, T; Gonzalez, J; Aranda, E

Degradation of bisphenol A and acute toxicity reduction by different thermo-tolerant ascomycete strains isolated from arid soils

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 2018;

FI:3,974; Q1

Romero, A; Gonzalez, J; Pecos, R; Deen, MJ; Jimenez-Tejada, JA

Evolutionary parameter extraction for an organic TFT compact model including contact effects

ORGANIC ELECTRONICS, 2018;

FI:3,68; Q1

Potes, Y; Olivan, M; Rubio-Gonzalez, A; de Luxan-Delgado, B; Diaz, F; Sierra, V; Arroyo, L; Pena, R; Bassols, A; Gonzalez, J; Carreras, R; Velarde, A; Munoz-Torres, M; Coto-Montes, A

Pig cognitive bias affects the conversion of muscle into meat by antioxidant and autophagy mechanisms

ANIMAL, 2017;

FI:1,921; D1

De-Ugarte, L; Caro-Molina, E; Rodriguez-Sanz, M; Garcia-Perez, MA; Olmos, JM; Sosa-Henriquez, M; Perez-Cano, R; Gomez-Alonso, C; Del Rio, L; Mateo-Agudo, J; Blazquez-Cabrera, JA; Gonzalez-Macias, J; del Pino-Montes, J; Munoz-Torres, M; Diaz-Curiel, M; Malouf, J; Cano, A; Perez-Castrillon, JL; Nogues, X; Garcia-Giralt, N; Diez-Perez, A

SNPs in bone-related miRNAs are associated with the osteoporotic phenotype

SCIENTIFIC REPORTS, 2017;

FI:4,259; Q1

Jardine, MJ; Mahaffey, KW; Neal, B; Agarwal, R; Bakris, GL; Brenner, BM; Bull, S; Cannon, CP; Charytan, DM; de Zeeuw, D; Edwards, R; Greene, T; Heerspink, HJL; Levin, A; Pollock, C; Wheeler, DC; Xie, J; Zhang, H; Zinman, B; Desai, M; Perkovic, V

The Canagliflozin and Renal Endpoints in Diabetes with Established Nephropathy Clinical Evaluation (CREDENCE) Study Rationale, Design, and Baseline Characteristics

AMERICAN JOURNAL OF NEPHROLOGY, 2017;

FI:2,542; Q2

Reyes-Garcia, R; Rozas-Moreno, P; Llamoza-Torres, CJ; Mezquita-Raya, P

Non-alcoholic fatty liver disease and diabetes

MEDICINA CLINICA, 2017;

FI:1,125; Q3

Fernandez-Soto, ML; Martin-Leyva, A; Gonzalez-Jimenez, A; Garcia-Rubio, J; Cozar-Ibanez, A; Zamora-Camacho, FJ; Leyva-Martinez, MS; Jimenez-Rios, JA; Escobar-Jimenez, F

Remission of type 2 diabetes mellitus after bariatric surgery – comparison between procedures

ENDOKRYNOLOGIA POLSKA, 2017;

FI:1,341; Q4

Garcia-Fontana, C; Narvaez-Reinaldo, JJ; Castillo, F; Gonzalez-Lopez, J; Luque, I; Manzanera, M

A New Physiological Role for the DNA Molecule as a Protector against Drying Stress in Desiccation-Tolerant Microorganisms

FRONTIERS IN MICROBIOLOGY, 2016;

FI:4,165; Q1

Garcia-Fontana, B; Morales-Santana, S; Navarro, CD; Rozas-Moreno, P; Genilloud, O; Perez, FV; del Palacio, JP; Munoz-Torres, M

Metabolomic profile related to cardiovascular disease in patients with type 2 diabetes mellitus: A pilot study

TALANTA, 2016;

FI:4,035; Q1

Webb, SM; Puig-Domingo, M; Villabona, C; Munoz-Torres, M; Marazuela, M; Fernandez, D; Martinez, G; Jodar, E; Mangas, MA; Perulero, N; Badia, X

Validation of PHPQoL, a Disease-Specific Quality-of-Life Questionnaire for Patients With Primary Hyperparathyroidism

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2016;

FI:5,531; Q1

Garcia-Fontana, B; Reyes-Garcia, R; Morales-Santana, S; Avila-Rubio, V; Munoz-Garach, A; Rozas-Moreno, P; Munoz-Torres, M

Relationship between myostatin and irisin in type 2 diabetes mellitus: a compensatory mechanism to an unfavourable metabolic state?

ENDOCRINE, 2016;

FI:3,279; Q2

Fonolla-Joya, J; Reyes-Garcia, R; Garcia-Martin, A; Lopez-Huertas, E; Munoz-Torres, M

Daily Intake of Milk Enriched with n-3 Fatty Acids, Oleic Acid, and Calcium Improves Metabolic and Bone Biomarkers in Postmenopausal Women

JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION, 2016;

FI:2,245; Q3

Arrebola, JP; Gonzalez-Jimenez, A; Fornieles-Gonzalez, C; Artacho-Cordon, F; Olea, N; Escobar-Jimenez, F; Fernandez-Soto, ML

Relationship between serum concentrations of persistent organic pollutants and markers of insulin resistance in a cohort of women with a history of gestational diabetes mellitus

ENVIRONMENTAL RESEARCH, 2015;

FI:4,373; D1

Unciti-Broceta, JD; Arias, JL; Maceira, J; Soriano, M; Ortiz-Gonzalez, M; Hemandez-Quero, J; Munoz-Torres, M; de Koning, HP; Magez, S; Garcia-Salcedo, JA

Specific Cell Targeting Therapy Bypasses Drug Resistance Mechanisms in African Trypanosomiasis

PLOS PATHOGENS, 2015;

FI:7,562; D1

Morales-Santana, S; Diez-Perez, A; Olmos, JM; Nogues, X; Sosa, M; Diaz-Curiel, M; Perez-Castrillon, JL; Perez-Cano, R; Torrijos, A; Jodar, E; Del Rio, L; Caeiro-Rey, JR; Reyes-Garcia, R; Garcia-Fontana, B; Gonzalez-Macias, J; Munoz-Torres, M

Circulating sclerostin and estradiol levels are associated with inadequate response to bisphosphonates in postmenopausal women with osteoporosis

MATURITAS, 2015;

FI:2,942; Q1

García-Fontana B; Morales-Santana S; Díaz Navarro C; Rozas-Moreno P; Genilloud O; Vicente Pérez

Metabolomic profile related to cardiovascular disease in patients with type 2 diabetes mellitus: A pilot study.

TALANTA, 2015;

FI:3,545; Q1

Hollander, P; King, AB; Del Prato, S; Sreenan, S; Balci, MK; Munoz-Torres, M; Rosenstock, J; Hansen, CT; Niemeyer, M; Garber, AJ

Insulin degludec improves long-term glycaemic control similarly to insulin glargine but with fewer hypoglycaemic episodes in patients with advanced type 2 diabetes on basal-bolus insulin therapy

DIABETES OBESITY & METABOLISM, 2015;

FI:6,36; Q1

Implicaciones multisist émicas de la Hipofosfatasia: Papel de la microbiota y caracterizaci ó n geno-fenot ípica de nuevas variantes en población infantil y adulta

Financiador: INSTITUTO DE SALUD CARLOS III

Número de expediente: PI21/01069

Tiempo de ejecución: 01/01/2022 - 31/12/2024

IP: BEATRIZ GARCIA FONTANA

Efecto combinado del ejercicio y la restricción horaria de la ingesta sobre la grasa ectópica y la salud metabólica en personas obesas: Estudio EXTREME

Financiador: UNIVERSIDAD DE GRANADA

Número de expediente: A-CTS-516-UGR20

Tiempo de ejecución: 01/01/2022 - 30/06/2023

IP: MANUEL EDUARDO MUÑOZ TORRES

CB16/10/00475 CIBER – AREA TEMÁTICA DE FRAGILIDAD Y ENVEJECIMIENTO

Financiador: INSTITUTO DE SALUD CARLOS III

Número de expediente: CB16/10/00475

Tiempo de ejecución: 01/01/2017 - 31/12/2018

IP: MANUEL EDUARDO MUÑOZ TORRES

Relación entre parámetros de trabecular bone score (TBS), enfermedad cardiovascular y fragilidad ósea en pacientes con diabetes tipo 2

Financiador: INSTITUTO DE SALUD CARLOS III

Número de expediente: PI15/01207

Tiempo de ejecución: 01/01/2016 - 31/12/2018

IP: MANUEL EDUARDO MUÑOZ TORRES

Identificación de Proteínas Implicadas en Calcificación Vascular y Mineralización Ósea en Pacientes Con Diabetes Mellitus Tipo 2

Financiador: CONSEJERÍA DE SALUD

Número de expediente: PI-0207-2016

Tiempo de ejecución: 01/01/2017 - 31/12/2019

IP: BEATRIZ GARCIA FONTANA

RELACIÓN ENTRE PARÁMETROS ESTRUCTURALES ÓSEOS OBTENIDOS MEDIANTE ANÁLISIS 3D (3D-SHAPER) Y ENFERMEDAD CARDIOVASCULAR EN PAIENTES CON DIABETES TIPO 2.

Financiador: FUNDACIÓN ESPAÑOLA DE INVESTIGACIÓN ÓSEA Y DEL METABOLISMO MINERAL

Número de expediente: FEIOMM-18-001-MMT

Tiempo de ejecución: 28/11/2018 - 31/12/2019

IP: MANUEL EDUARDO MUÑOZ TORRES

ESTUDIO RETROSPECTIVO DE PREVALENCIA DE HIPOFOSFATASIA EN GRANADA

Financiador: FUNDACIÓN ESPAÑOLA DE INVESTIGACIÓN ÓSEA Y DEL METABOLISMO MINERAL

Número de expediente: FEIOMM17-002

Tiempo de ejecución: 13/11/2017 - 02/12/2019

IP: MANUEL EDUARDO MUÑOZ TORRES

CLONAJE Y EXPRESIÓN DE ESLEROSTINA RECOMBINANTE PARA EL ESTUDIO DE SU FUNCIÓN A NIVEL VASCULAR.

Financiador: FUNDACIÓN ESPAÑOLA DE INVESTIGACIÓN ÓSEA Y DEL METABOLISMO MINERAL

Número de expediente: FEIOMM-18-002-BGF

Tiempo de ejecución: 08/11/2018 - 31/12/2019

IP: BEATRIZ GARCIA FONTANA

Evaluación de parámetros estructurales óseos obtenidos mediante análisis 3D (3D-Shaper) en pacientes con diabetes tipo 2 y su relación con la enfermedad cardiovascular.

Financiador: INSTITUTO DE SALUD CARLOS III

Número de expediente: PI18/01235

Tiempo de ejecución: 01/01/2019 - 31/12/2021

IP: MANUEL EDUARDO MUÑOZ TORRES

Caracterización a nivel transcripcional de los genes implicados en calcificación vascular en pacientes diabéticos. Estudio in silico de las proteínas óseas esclerostina y osteoglicina para diseño de posibles inhibidores como tratamiento preventivo de ca

Financiador: CONSEJERÍA DE SALUD Y FAMILIAS

Número de expediente: PI-0514-2018

Tiempo de ejecución: 01/01/2019 - 31/12/2021

IP: CRISTINA GARCIA FONTANA

PARADIGHM (Médicos avanzando en el conocimiento del Hipoparatiroidismo crónico): Un estudio de registro para pacientes con Hipoparatiroidismo. SHI-PTH-2019-01

Financiador: TAKEDA PHARMACEUTICALS INTERNATIONAL AG

Tipo de prueba: ESTUDIO POSAUTORIZACION COMERCIAL

Tiempo de ejecución: 23/11/2020 - 30/12/2034

IP: MANUEL EDUARDO MUÑOZ TORRES

Estudio de fase IIb, multicentrico, aleatorizado, doble ciego y controlado con placebo de verinurad y alopurinol en pacientes con nefropatia cronica e hyperuricemia. SAPPHIRE

Financiador: ASTRAZENECA AB

Tipo de prueba: ENSAYO CLINICO COMERCIAL

Tiempo de ejecución: 20/11/2019 - 30/08/2021

IP: MANUEL EDUARDO MUÑOZ TORRES

MP20-Biomarcadores de Enfermedades Metabólicas y Óseas

Líneas de investigación

Redes de investigación

Palabras clave

FRANCISCO JOSE AMARO GAHETE

JONATAN RUIZ RUIZ

MARIA TRINIDAD GONZALEZ CEJUDO

FRANCISCO LUIS ANDUJAR VERA

ARACELI MUÑOZ GARACH

VICTORIA CONTRERAS BOLIVAR

SILVIA LOZANO ALONSO

ENRIQUE MORATALLA ARANDA

MANUEL EDUARDO MUÑOZ TORRES

MANUEL MUÑOZ GARACH

CRISTINA NOVO RODRIGUEZ

REBECA REYES GARCÍA

JUAN MIGUEL VILLA SUAREZ

CARMEN YESTE DOBLAS

VERONICA AVILA RUBIO

MARIA DOLORES AVILES PEREZ

MARIA LUISA FERNANDEZ SOTO

BEATRIZ GARCIA FONTANA

ANTONIA GARCIA MARTIN

CRISTINA GARCIA FONTANA

SHEILA GONZALEZ SALVATIERRA

PABLO JOSE LOPEZ-IBARRA LOZANO

Investigación