BIOMARCADORES HTA Y DISFUNCION RENAL
Grupos de investigación IBS-MP-08
BIOMARCADORES HTA Y DISFUNCION RENAL
La Línea de investigación general del grupo es el estudio de la fisiología y fisiopatología de la hipertensión arterial, disfunción renal y disfunción tiroidea. Además, tiene como objetivo la búsqueda de nuevos biomarcadores de lesión y de fibrosis renal.
Lineas de investigación
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Palabras clave
Hipertensión, Disfunción Endotelial, Disfunción Renal, Disfunción Tiroidea, Biomarcadores.
| Miembro |
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| OSUNA ORTEGA, ANTONIO |
| RODRÍGUEZ GÓMEZ, ISABEL MARÍA |
| VARGAS PALOMARES, JOSÉ FÉLIX |
| DE GRACIA GUINDO, Mª DEL CARMEN |
| QUESADA MIÑARRO, ANDRÉS |
| RUIZ FUENTES, MARIA DEL CARMEN |
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Cruz-Bustos T, Ibarrola-Vannucci AK, Díaz-Lozano I, Ramírez JL, Osuna A
Characterization and functionality of two members of the SPFH protein superfamily, prohibitin 1 and 2 in Leishmania major.
Parasites & vectors, 2018; 11(1); 622
FI: 3.163; Q1 / D2
Gomez-Samblas M, Bernal D, Bolado-Ortiz A, Vilchez S, Bolás-Fernández F, Espino AM, Trelis M, Osuna A
Intraperitoneal administration of the anti-IL-23 antibody prevents the establishment of intestinal nematodes in mice.
Scientific reports, 2018; 8(1); 7787
FI: 4.122; Q1 / D2
Moreso F, Crespo M, Ruiz JC, Torres A, Gutierrez-Dalmau A, Osuna A, Perelló M, Pascual J, Torres IB, Redondo-Pachón D, Rodrigo E, Lopez-Hoyos M, Seron D
Treatment of chronic antibody mediated rejection with intravenous immunoglobulins and rituximab: A multicenter, prospective, randomized, double-blind clinical trial.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2018; 18(4); 927-935
FI: 6.493; Q1 / D1
Garcia-Ramon DC, Berry C, Tse C, Fernández-Fernández A, Osuna A, Vílchez S
The parasporal crystals of Bacillus pumilus strain 15.1: a potential virulence factor?
Microbial biotechnology, 2018; 11(2); 302-316
FI: 3.913; Q1 / D3
Montoro-Molina S, López-Carmona A, Quesada A, O'Valle F, Martín-Morales N, Osuna A, Vargas F, Wangensteen R
Klotho and Aminopeptidases as Early Biomarkers of Renal Injury in Zucker Obese Rats.
Frontiers in physiology, 2018; 9; 1599
FI: 3.394; Q1 / D3
Vargas F, Romecín P, García-Guillén AI, Wangesteen R, Vargas-Tendero P, Paredes MD, Atucha NM, García-Estañ J
Flavonoids in Kidney Health and Disease.
Frontiers in physiology, 2018; 9; 394
FI: 3.394; Q1 / D3
Quesada A, Segarra AB, Montoro-Molina S, de Gracia MD, Osuna A, O'Valle F, Gómez-Guzmán M, Vargas F, Wangensteen R
Glutamyl aminopeptidase in microvesicular and exosomal fractions of urine is related with renal dysfunction in cisplatin-treated rats.
PloS one, 2017; 12(4); e0175462
FI: 2.766; Q1 / D3
Porrini EL, Díaz JM, Moreso F, Delgado Mallén PI, Silva Torres I, Ibernon M, Bayés-Genís B, Benitez-Ruiz R, Lampreabe I, Lauzurrica R, Osorio JM, Osuna A, Domínguez-Rollán R, Ruiz JC, Jiménez-Sosa A, González-Rinne A, Marrero-Miranda D, Macía M, García J, Torres A
Clinical evolution of post-transplant diabetes mellitus.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2016; 31(3); 495-505
FI: 4.47; Q1 / D2
Gomez-Samblas M, Vílchez S, Racero JC, Fuentes MV, Osuna A
Quantification and viability assays of Toxoplasma gondii in commercial "Serrano" ham samples using magnetic capture real-time qPCR and bioassay techniques.
Food microbiology, 2015; 46; 107-13
FI: 3.682; Q1 / D1
Campelo R, Díaz Lozano I, Figarella K, Osuna A, Ramírez JL
Leishmania major telomerase TERT protein has a nuclear/mitochondrial eclipsed distribution that is affected by oxidative stress.
Infection and immunity, 2015; 83(1); 57-66
FI: 3.603; Q1 / D3
Perez A, Gonzalez-Manzano S, Jimenez R, Perez-Abud R, Haro JM, Osuna A, Santos-Buelga C, Duarte J, Perez-Vizcaino F
The flavonoid quercetin induces acute vasodilator effects in healthy volunteers: correlation with beta-glucuronidase activity.
Pharmacological research, 2014; 89; 11-8
FI: 4.408; Q1 / D2
Ferreyra C, Vargas F, Rodríguez-Gómez I, Pérez-Abud R, O'Valle F, Osuna A
Preconditioning with triiodothyronine improves the clinical signs and acute tubular necrosis induced by ischemia/reperfusion in rats.
PloS one, 2013; 8(9); e74960
FI: 3.534; Q1 / D2
Rodríguez-Gómez I, Wangensteen R, Pérez-Abud R, Quesada A, Del Moral RG, Osuna A, O'Valle F, de Dios Luna J, Vargas F
Long-term consequences of uninephrectomy in male and female rats.
Hypertension, 2012; 60(6); 1458-63
FI: 6.873; Q1 / D1
Quintela AM, Jiménez R, Gómez-Guzmán M, Zarzuelo MJ, Galindo P, Sánchez M, Vargas F, Cogolludo A, Tamargo J, Pérez-Vizcaíno F, Duarte J
Activation of peroxisome proliferator-activated receptor-β/-δ (PPARβ/δ) prevents endothelial dysfunction in type 1 diabetic rats.
Free radical biology & medicine, 2012; 53(4); 730-41
FI: 5.271; Q1 / D2
Quesada A, Vargas F, Montoro-Molina S, O'Valle F, Rodríguez-Martínez MD, Osuna A, Prieto I, Ramírez M, Wangensteen R
Urinary aminopeptidase activities as early and predictive biomarkers of renal dysfunction in cisplatin-treated rats.
PloS one, 2012; 7(7); e40402
FI: 3.73; Q1 / D2
Galindo P, Rodriguez-Gómez I, González-Manzano S, Dueñas M, Jiménez R, Menéndez C, Vargas F, Tamargo J, Santos-Buelga C, Pérez-Vizcaíno F, Duarte J
Glucuronidated quercetin lowers blood pressure in spontaneously hypertensive rats via deconjugation.
PloS one, 2012; 7(3); e32673
FI: 3.73; Q1 / D2
Gómez-Guzmán M, Jiménez R, Sánchez M, Zarzuelo MJ, Galindo P, Quintela AM, López-Sepúlveda R, Romero M, Tamargo J, Vargas F, Pérez-Vizcaíno F, Duarte J
Epicatechin lowers blood pressure, restores endothelial function, and decreases oxidative stress and endothelin-1 and NADPH oxidase activity in DOCA-salt hypertension.
Free radical biology & medicine, 2012; 52(1); 70-9
FI: 5.271; Q1 / D2
Guirado L, Cantarell C, Franco A, Huertas EG, Fructuoso AS, Fernández A, Gentil MA, Rodríguez A, Paul J, Torregrossa JV, Rodríguez A, Alonso A, Hernández D, Burgos D, Jiménez C, Jimeno L, Lauzurica R, Mazuecos A, Osuna A, Plumed JS, Ruiz JC, Zárraga S, GREAT Study Group
Efficacy and safety of conversion from twice-daily to once-daily tacrolimus in a large cohort of stable kidney transplant recipients.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2011; 11(9); 1965-71
FI: 6.394; Q1 / D1
Perez-Abud R, Rodríguez-Gómez I, Villarejo AB, Moreno JM, Wangensteen R, Tassi M, O'Valle F, Osuna A, Vargas F
Salt sensitivity in experimental thyroid disorders in rats.
American journal of physiology. Endocrinology and metabolism, 2011; 301(2); E281-7
FI: 4.746; Q1 / D1
Porrini E, Bayes B, Diaz JM, Ibernon M, Benitez R, Domínguez R, Moreno JM, Delgado P, Lauzurica R, Silva I, Moreso F, Lampreabe I, Arias M, Osuna A, Torres A
Hyperinsulinemia and hyperfiltration in renal transplantation.
Transplantation, 2009; 87(2); 274-9
FI: 3.498; Q1 / D1
O'Valle F, Del Moral RG, Benítez Mdel C, Martín-Oliva D, Gómez-Morales M, Aguilar D, Aneiros-Fernández J, Hernández-Cortés P, Osuna A, Moreso F, Serón D, Oliver FJ, Del Moral RG
Poly[ADP-ribose] polymerase-1 expression is related to cold ischemia, acute tubular necrosis, and delayed renal function in kidney transplantation.
PloS one, 2009; 4(9); e7138
FI: 4.351; Q1 / D2
Delgado P, Diaz JM, Silva I, Osorio JM, Osuna A, Bayés B, Lauzurica R, Arellano E, Campistol JM, Dominguez R, Gómez-Alamillo C, Ibernon M, Moreso F, Benitez R, Lampreave I, Porrini E, Torres A
Unmasking glucose metabolism alterations in stable renal transplant recipients: a multicenter study.
Clinical journal of the American Society of Nephrology : CJASN, 2008; 3(3); 808-13
FI: 4.361; Q1 / D2
Porrini E, Moreno JM, Osuna A, Benitez R, Lampreabe I, Diaz JM, Silva I, Domínguez R, Gonzalez-Cotorruelo J, Bayes B, Lauzurica R, Ibernon M, Moreso F, Delgado P, Torres A
Prediabetes in patients receiving tacrolimus in the first year after kidney transplantation: a prospective and multicenter study.
Transplantation, 2008; 85(8); 1133-8
FI: 3.816; Q1 / D1
López-Sepúlveda R, Jiménez R, Romero M, Zarzuelo MJ, Sánchez M, Gómez-Guzmán M, Vargas F, O'Valle F, Zarzuelo A, Pérez-Vizcaíno F, Duarte J
Wine polyphenols improve endothelial function in large vessels of female spontaneously hypertensive rats.
Hypertension, 2008; 51(4); 1088-95
FI: 7.368; Q1 / D1
Porrini, E; Bayes, B; Diaz, J; Moreno-Ayuso, J; Benitez, R; Ibernon, M; Dominguez, R; Lauzurica, R; Irene, S; Osuna, A; Lampreave, I; Moreso, F; Lopez-Alamillo, A; Delgado, P; Torres, A
Hyperinsulinemia: A risk factor for relative hyperfiltration during the first year after renal transplantation
AMERICAN JOURNAL OF TRANSPLANTATION, 2008; 8;
FI: 6.559; Q1 / D1
Jiménez R, López-Sepúlveda R, Kadmiri M, Romero M, Vera R, Sánchez M, Vargas F, O'Valle F, Zarzuelo A, Dueñas M, Santos-Buelga C, Duarte J
Polyphenols restore endothelial function in DOCA-salt hypertension: role of endothelin-1 and NADPH oxidase.
Free radical biology & medicine, 2007; 43(3); 462-73
FI: 4.813; Q1 / D1
Vargas F, Moreno JM, Wangensteen R, Rodríguez-Gómez I, García-Estañ J
The endocrine system in chronic nitric oxide deficiency.
European journal of endocrinology / European Federation of Endocrine Societies, 2007; 156(1); 1-12
FI: 3.239; Q1 / D2
