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López-Isac E, Acosta-Herrera M, Kerick M, Assassi S, Satpathy AT, Granja J, Mumbach MR, Beretta L, Simeón CP, Carreira P, Ortego-Centeno N, Castellvi I, Bossini-Castillo L, Carmona FD, Orozco G, Hunzelmann N, Distler JHW, Franke A, Lunardi C, Moroncini G, Gabrielli A, de Vries-Bouwstra J, Wijmenga C, Koeleman BPC, Nordin A, Padyukov L, Hoffmann-Vold AM, Lie B, European Scleroderma Group†, Proudman S, Stevens W, Nikpour M, Australian Scleroderma Interest Group (ASIG), Vyse T, Herrick AL, Worthington J, Denton CP, Allanore Y, Brown MA, Radstake TRDJ, Fonseca C, Chang HY, Mayes MD, Martin J

GWAS for systemic sclerosis identifies multiple risk loci and highlights fibrotic and vasculopathy pathways.

Nature communications, 2019; 10(1); 4955

Soriano-Maldonado A, Morillas-de-Laguno P, Sabio JM, Gavilán-Carrera B, Rosales-Castillo A, Montalbán-Méndez C, Sáez-Urán LM, Callejas-Rubio JL, Vargas-Hitos JA

Effects of 12-week Aerobic Exercise on Arterial Stiffness, Inflammation, and Cardiorespiratory Fitness in Women with Systemic LUPUS Erythematosus: Non-Randomized Controlled Trial.

Journal of clinical medicine, 2018; 7(12);

Marí-Alfonso B, Simeón-Aznar CP, Guillén-Del Castillo A, Rubio-Rivas M, Trapiella-Martínez L, Todolí-Parra JA, Rodríguez Carballeira M, Marín-Ballvé A, Iniesta-Arandia N, Colunga-Argüelles D, Castillo-Palma MJ, Sáez-Comet L, Egurbide-Arberas MV, Ortego-Centeno N, Freire M, Vargas Hitos JA, Chamorro AJ, Madroñero-Vuelta AB, Perales-Fraile I, Pla-Salas X, Fernández-De-La-Puebla RA, Fonollosa-Pla V, Tolosa-Vilella C, RESCLE Investigators, Systemic Autoimmune Diseases Study Group (GEAS)

Hepatobiliary involvement in systemic sclerosis and the cutaneous subsets: Characteristics and survival of patients from the Spanish RESCLE Registry.

Seminars in arthritis and rheumatism, 2018; 47(6); 849-857

González-Serna D, Ortiz-Fernández L, Vargas S, García A, Raya E, Fernández-Gutierrez B, López-Longo FJ, Balsa A, González-Álvaro I, Narvaez J, Gómez-Vaquero C, Sabio JM, García-Portales R, González-Escribano MF, Tolosa C, Carreira P, Kiemeney L, Coenen MJH, Witte T, Schneider M, González-Gay MÁ, Martín J

Association of a rare variant of the TNFSF13B gene with susceptibility to Rheumatoid Arthritis and Systemic Lupus Erythematosus.

Scientific reports, 2018; 8(1); 8195

Montalbán-Méndez C, Soriano-Maldonado A, Vargas-Hitos JA, Sáez-Urán LM, Rosales-Castillo A, Morillas-de-Laguno P, Gavilán-Carrera B, Jiménez-Alonso J

Cardiorespiratory fitness and age-related arterial stiffness in women with systemic lupus erythematosus.

European journal of clinical investigation, 2018; 48(3);

Soriano-Maldonado A, Vargas-Hitos JA, Jiménez-Jáimez J

Exercise for Patients With Hypertrophic Cardiomyopathy.

JAMA, 2017; 318(5); 480-481

Trapiella-Martínez L, Díaz-López JB, Caminal-Montero L, Tolosa-Vilella C, Guillén-Del Castillo A, Colunga-Argüelles D, Rubio-Rivas M, Iniesta-Arandia N, Castillo-Palma MJ, Sáez-Comet L, Egurbide-Arberas MV, Ortego-Centeno N, Freire M, Vargas-Hitos JA, Ríos-Blanco JJ, Todolí-Parra JA, Rodríguez-Carballeira M, Marín-Ballvé A, Chamorro-Fernández AJ, Pla-Salas X, Madroñero-Vuelta AB, Ruiz-Muñóz M, Fonollosa-Pla V, Simeón-Aznar CP, RESCLE Investigators, on Behalf of the Autoimmune Diseases Study Group (GEAS), Spanish Society of Internal Medicine (SEMI)

Very early and early systemic sclerosis in the Spanish scleroderma Registry (RESCLE) cohort.

Autoimmunity reviews, 2017; 16(8); 796-802

Langefeld CD, Ainsworth HC, Cunninghame Graham DS, Kelly JA, Comeau ME, Marion MC, Howard TD, Ramos PS, Croker JA, Morris DL, Sandling JK, Almlöf JC, Acevedo-Vásquez EM, Alarcón GS, Babini AM, Baca V, Bengtsson AA, Berbotto GA, Bijl M, Brown EE, Brunner HI, Cardiel MH, Catoggio L, Cervera R, Cucho-Venegas JM, Dahlqvist SR, D'Alfonso S, Da Silva BM, de la Rúa Figueroa I, Doria A, Edberg JC, Endreffy E, Esquivel-Valerio JA, Fortin PR, Freedman BI, Frostegård J, García MA, de la Torre IG, Gilkeson GS, Gladman DD, Gunnarsson I, Guthridge JM, Huggins JL, James JA, Kallenberg CGM, Kamen DL, Karp DR, Kaufman KM, Kottyan LC, Kovács L, Laustrup H, Lauwerys BR, Li QZ, Maradiaga-Ceceña MA, Martín J, McCune JM, McWilliams DR, Merrill JT, Miranda P, Moctezuma JF, Nath SK, Niewold TB, Orozco L, Ortego-Centeno N, Petri M, Pineau CA, Pons-Estel BA, Pope J, Raj P, Ramsey-Goldman R, Reveille JD, Russell LP, Sabio JM, Aguilar-Salinas CA, Scherbarth HR, Scorza R, Seldin MF, Sjöwall C, Svenungsson E, Thompson SD, Toloza SMA, Truedsson L, Tusié-Luna T, Vasconcelos C, Vilá LM, Wallace DJ, Weisman MH, Wither JE, Bhangale T, Oksenberg JR, Rioux JD, Gregersen PK, Syvänen AC, Rönnblom L, Criswell LA, Jacob CO, Sivils KL, Tsao BP, Schanberg LE, Behrens TW, Silverman ED, Alarcón-Riquelme ME, Kimberly RP, Harley JB, Wakeland EK, Graham RR, Gaffney PM, Vyse TJ

Transancestral mapping and genetic load in systemic lupus erythematosus.

Nature communications, 2017; 8; 16021

Sabio, JM

Systemic inflammation and endothelial dysfunction-a possible link between osteoarthritis and hypertension: comment on the article by Niu et al

ARTHRITIS & RHEUMATOLOGY, 2017; 69;

Márquez A, Vidal-Bralo L, Rodríguez-Rodríguez L, González-Gay MA, Balsa A, González-Álvaro I, Carreira P, Ortego-Centeno N, Ayala-Gutiérrez MM, García-Hernández FJ, González-Escribano MF, Sabio JM, Tolosa C, Suárez A, González A, Padyukov L, Worthington J, Vyse T, Alarcón-Riquelme ME, Martín J

A combined large-scale meta-analysis identifies COG6 as a novel shared risk locus for rheumatoid arthritis and systemic lupus erythematosus.

Annals of the rheumatic diseases, 2017; 76(1); 286-294

Tolosa-Vilella C, Morera-Morales ML, Simeón-Aznar CP, Marí-Alfonso B, Colunga-Arguelles D, Callejas Rubio JL, Rubio-Rivas M, Freire-Dapena M, Guillén-Del Castillo A, Iniesta-Arandia N, Castillo-Palma MJ, Egurbide-Arberas M, Trapiellla-Martínez L, Vargas-Hitos JA, Todolí-Parra JA, Rodriguez-Carballeira M, Marin-Ballvé A, Pla-Salas X, Rios-Blanco JJ, Fonollosa-Pla V, RESCLE Investigators, Autoimmune Diseases Study Group (GEAS)

Digital ulcers and cutaneous subsets of systemic sclerosis: Clinical, immunological, nailfold capillaroscopy, and survival differences in the Spanish RESCLE Registry.

Seminars in arthritis and rheumatism, 2016; 46(2); 200-8

Vargas-Hitos JA, Sabio JM, Navarrete-Navarrete N, Zamora-Pasadas M, Jiménez-Alonso J

Severe digital necrosis as the clinical onset of antiphospholipid syndrome.

Internal and emergency medicine, 2016; 11(5); 761-2

Rivera-López R, Jiménez-Jáimez J, Sabio JM, Zamora-Pasadas M, Vargas-Hitos JA, Martínez-Bordonado J, Navarrete-Navarrete N, Fernández RR, Sanchez-Cantalejo E, Jiménez-Alonso J

Relationship between QT Interval Length and Arterial Stiffness in Systemic Lupus Erythematosus (SLE): A Cross-Sectional Case-Control Study.

PloS one, 2016; 11(4); e0152291

Vargas-Hitos JA, Roa-Chamorro R, Sabio JM, Javier-Martínez R, Martín-Castro A, Jiménez-Alonso J

Leishmaniasis, lupus nephritis and immunosuppressive therapy.

QJM : monthly journal of the Association of Physicians, 2016; 109(1); 51-2

Sabio JM, Vargas-Hitos JA, Martinez-Bordonado J, Navarrete-Navarrete N, Díaz-Chamorro A, Olvera-Porcel C, Zamora-Pasadas M, Jiménez-Alonso J

Relationship between homocysteine levels and hypertension in systemic lupus erythematosus.

Arthritis care & research, 2014; 66(10); 1528-35

Jaén-Águila F, Vargas-Hitos JA, Jiménez-Alonso J

Necrobiotic xanthogranuloma.

QJM : monthly journal of the Association of Physicians, 2014; 107(10); 859

Gómez-Guzmán M, Jiménez R, Romero M, Sánchez M, Zarzuelo MJ, Gómez-Morales M, O'Valle F, López-Farré AJ, Algieri F, Gálvez J, Pérez-Vizcaino F, Sabio JM, Duarte J

Chronic hydroxychloroquine improves endothelial dysfunction and protects kidney in a mouse model of systemic lupus erythematosus.

Hypertension, 2014; 64(2); 330-7

Jaén Águila F, Mediavilla García JD, Molina Navarro E, Vargas Hitos JA, Fernández-Torres C

Bilateral renal artery stenosis after renal denervation.

Hypertension, 2014; 63(5); e126-7

Cenit MC, Martínez-Florensa M, Consuegra M, Bonet L, Carnero-Montoro E, Armiger N, Caballero-Baños M, Arias MT, Benitez D, Ortego-Centeno N, de Ramón E, Sabio JM, García-Hernández FJ, Tolosa C, Suárez A, González-Gay MA, Bosch E, Martín J, Lozano F

Analysis of ancestral and functionally relevant CD5 variants in systemic lupus erythematosus patients.

PloS one, 2014; 9(11); e113090

Martin JE, Assassi S, Diaz-Gallo LM, Broen JC, Simeon CP, Castellvi I, Vicente-Rabaneda E, Fonollosa V, Ortego-Centeno N, González-Gay MA, Espinosa G, Carreira P, Spanish Scleroderma Group, SLEGEN consortium, U.S. Scleroderma GWAS group, BIOLUPUS, Camps M, Sabio JM, D'alfonso S, Vonk MC, Voskuyl AE, Schuerwegh AJ, Kreuter A, Witte T, Riemekasten G, Hunzelmann N, Airo P, Beretta L, Scorza R, Lunardi C, Van Laar J, Chee MM, Worthington J, Herrick A, Denton C, Fonseca C, Tan FK, Arnett F, Zhou X, Reveille JD, Gorlova O, Koeleman BP, Radstake TR, Vyse T, Mayes MD, Alarcón-Riquelme ME, Martin J

A systemic sclerosis and systemic lupus erythematosus pan-meta-GWAS reveals new shared susceptibility loci.

Human molecular genetics, 2013; 22(19); 4021-9

Navarrete-Navarrete N, Jimenez-Alonso J, Sabio JM, Peralta-Ramirez MI

Pain and psychological distress in patients with systemic lupus erythematosus: comment on the article by Somers et al.

Arthritis care & research, 2013; 65(7); 1204

Diaz-Gallo LM, Sánchez E, Ortego-Centeno N, Sabio JM, García-Hernández FJ, de Ramón E, González-Gay MA, Torsten Witte null, Anders HJ, González-Escribano MF, Martin J

Evidence of new risk genetic factor to systemic lupus erythematosus: the UBASH3A gene.

PloS one, 2013; 8(4); e60646

Jaén Águila F, Vargas-Hitos JA, Esteva Fernández D, Jiménez Alonso J

A farmer with chest pain and lung nodules.

Cleveland Clinic journal of medicine, 2012; 79(7); 465-7

Simeón-Aznar CP, Fonollosa-Plá V, Tolosa-Vilella C, Espinosa-Garriga G, Ramos-Casals M, Campillo-Grau M, García-Hernández FJ, Castillo-Palma MJ, Sánchez-Román J, Callejas-Rubio JL, Ortego-Centeno N, Egurbide-Arberas MV, Trapiellla-Martínez L, Gallego-Villalobos M, Sáez-Comet L, Velilla-Marco J, Camps-García MT, de Ramón-Garrido E, Esteban Marcos EM, Pallarés-Ferreres L, Hidalgo-Tenorio C, Sabio-Sánchez JM, Gómez-de la Torre R, Salvador-Cervello G, Rios-Blanco JJ, Gil-Aguado A, Vilardell-Tarrés M

Registry of the Spanish network for systemic sclerosis: clinical pattern according to cutaneous subsets and immunological status.

Seminars in arthritis and rheumatism, 2012; 41(6); 789-800

Vargas-Hitos JA, Ateka-Barrutia O, Sangle S, Khamashta MA

Efficacy and safety of long-term low molecular weight heparin in patients with antiphospholipid syndrome.

Annals of the rheumatic diseases, 2011; 70(9); 1652-4

Namjou B, Kothari PH, Kelly JA, Glenn SB, Ojwang JO, Adler A, Alarcón-Riquelme ME, Gallant CJ, Boackle SA, Criswell LA, Kimberly RP, Brown E, Edberg J, Stevens AM, Jacob CO, Tsao BP, Gilkeson GS, Kamen DL, Merrill JT, Petri M, Goldman RR, Vila LM, Anaya JM, Niewold TB, Martin J, Pons-Estel BA, Sabio JM, Callejas JL, Vyse TJ, Bae SC, Perrino FW, Freedman BI, Scofield RH, Moser KL, Gaffney PM, James JA, Langefeld CD, Kaufman KM, Harley JB, Atkinson JP

Evaluation of the TREX1 gene in a large multi-ancestral lupus cohort.

Genes and immunity, 2011; 12(4); 270-9

Catalá-Rabasa A, Ndagire D, Sabio JM, Fedetz M, Matesanz F, Alcina A

High ACSL5 transcript levels associate with systemic lupus erythematosus and apoptosis in Jurkat T lymphocytes and peripheral blood cells.

PloS one, 2011; 6(12); e28591

Löfgren SE, Delgado-Vega AM, Gallant CJ, Sánchez E, Frostegård J, Truedsson L, de Ramón Garrido E, Sabio JM, González-Escribano MF, Pons-Estel BA, D'Alfonso S, Witte T, Lauwerys BR, Endreffy E, Kovács L, Vasconcelos C, Martins da Silva B, Martín J, Alarcón-Riquelme ME, Kozyrev SV

A 3'-untranslated region variant is associated with impaired expression of CD226 in T and natural killer T cells and is associated with susceptibility to systemic lupus erythematosus.

Arthritis and rheumatism, 2010; 62(11); 3404-14

García-Lozano JR, Abad C, Escalera A, Torres B, Fernández O, García A, Sánchez-Román J, Sabio JM, Ortego-Centeno N, Raya-Alvarez E, Núñez-Roldán A, Martín J, González-Escribano MF

Identification of HAVCR1 gene haplotypes associated with mRNA expression levels and susceptibility to autoimmune diseases.

Human genetics, 2010; 128(2); 221-9

Navarrete-Navarrete N, Peralta-Ramírez MI, Sabio-Sánchez JM, Coín MA, Robles-Ortega H, Hidalgo-Tenorio C, Ortego-Centeno N, Callejas-Rubio JL, Jiménez-Alonso J

Efficacy of cognitive behavioural therapy for the treatment of chronic stress in patients with lupus erythematosus: a randomized controlled trial.

Psychotherapy and psychosomatics, 2010; 79(2); 107-15

Sánchez E, Rueda B, Callejas JL, Sabio JM, Ortego-Centeno N, Jimenez-Alonso J, López-Nevot MA, Martín J

Analysis of interleukin-23 receptor (IL23R) gene polymorphisms in systemic lupus erythematosus.

Tissue antigens, 2007; 70(3); 233-7

Sánchez E, Abelson AK, Sabio JM, González-Gay MA, Ortego-Centeno N, Jiménez-Alonso J, de Ramón E, Sánchez-Román J, López-Nevot MA, Gunnarsson I, Svenungsson E, Sturfelt G, Truedsson L, Jönsen A, González-Escribano MF, Witte T, German Systemic Lupus Erythematosus Study Group, Alarcón-Riquelme ME, Martín J

Association of a CD24 gene polymorphism with susceptibility to systemic lupus erythematosus.

Arthritis and rheumatism, 2007; 56(9); 3080-6

Sanchez E, Callejas JL, Sabio JM, de Haro M, Camps M, de Ramón E, García-Hernández FJ, Koeleman B, Martín J, González-Escribano MF

Polymorphisms of the FCRL3 gene in a Spanish population of systemic lupus erythematosus patients.

Rheumatology (Oxford, England), 2006; 45(8); 1044-6

Sánchez E, Gómez LM, Lopez-Nevot MA, González-Gay MA, Sabio JM, Ortego-Centeno N, de Ramón E, Anaya JM, González-Escribano MF, Koeleman BP, Martín J

Evidence of association of macrophage migration inhibitory factor gene polymorphisms with systemic lupus erythematosus.

Genes and immunity, 2006; 7(5); 433-6

Sabio JM, Jiménez-Alonso J

Arterial thrombosis in systemic lupus erythematosus.

The New England journal of medicine, 2004; 351(18); 1910-1; author reply 1910-1

Hidalgo-Tenorio C, Jiménez-Alonso J, de Dios Luna J, Tallada M, Martínez-Brocal A, Sabio JM, Virgen de las Nieves Lupus Research Group

Urinary tract infections and lupus erythematosus.

Annals of the rheumatic diseases, 2004; 63(4); 431-7

Jiménez-Alonso J, Omar M, López-Nevot MA, Pérez-Alvarez F, Toribio M, Hidalgo C, Sabio JM

CD5+ B cells and uveitis.

Annals of the rheumatic diseases, 2002; 61(9); 854-5

Sabio JM, López-Gómez M, Jiménez-Alonso J

Spontaneous spondylodiscitis caused by Klebsiella oxytoca.

Annals of the rheumatic diseases, 2002; 61(8); 758-9

Hidalgo-Tenorio C, Sabio JM, Jiménez-Alonso J

Alopecia in Wegener's granulomatosis.

Annals of the rheumatic diseases, 2002; 61(7); 654-5

Jiménez-Alonso J, Jaimez L, Sabio JM, Hidalgo C, Leon L

Atorvastatin-induced reversible positive antinuclear antibodies.

The American journal of medicine, 2002; 112(4); 329-30

Título del proyecto: Efectos de Un Programa de Ejercicio Físico Sobre la Arteriosclerosis Subclínica y la Inflamación de Pacientes Con Lupus Eritematoso Sistémico

Financiador: CONSEJERIA DE SALUD

Nº Expediente: PI-0525-2016

Ejecución: 2017-2019

IP: JOSE ANTONIO VARGAS HITOS

Título del proyecto: Sindrome Metabólico y Aterosclerosis en lupus eritematoso sistémico

Financiador: CONSEJERÍA DE IGUALDAD, SALUD Y POLÍTICAS SOCIALES

Nº Expediente: IBS-292/05

Ejecución: 2006-2007

IP: JOSE MARIO SABIO

Título del ensayo: PARALLAX. Ensayo multicéntrico, aleatorizado, doble ciego, de grupos paralelos, con control activo y de 24 semanas de duración BNP, los síntomas, la capacidad de realizar ejercicio y la seguridad en comparación con el tratamiento médico individualizado de las comorbilidades en pacientes con insuficiencia cardíaca y fracción de eyección preservada.

Tipo de ensayo: ENSAYO CLINICO COMERCIAL

Financiador: NOVARTIS FARMACEUTICA, S.A.

Nº Expediente: 2016-003410-28

Ejecución: 2017-2019

IP: JOSE FRANCISCO DÍAZ FERNÁNDEZ

Título del ensayo: ESTUDIO DE FASE IIIB, PROSPECTIVO,ABIERTO, CON ENMASCARAMIENTO DE LOS EVALUADORES (PROBE) EN EL QUE SE EVALÚAN LA EFICACIA Y LA SEGURIDAD DE HEPARINA (BPM)/EDOXABÁN EN COMPARACIÓN CON DALTEPARINA PARA EL TROMBOEMBOLISMO VENOSO ASOCIADO AL CÁNCER

Tipo de ensayo: ENSAYO CLINICO COMERCIAL

Financiador: DAIICHI-SANKYO, INC

Nº Expediente: 2014-004708-30

Ejecución: 2016-2017

IP: LUIS JOSE JARA PALOMARES