MP04-Inmunogenética Enfermedades Sistémicas y Cutáneas

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El grupo de investigación se centra en el estudio de los marcadores inmunogeneticos y su relación con los mecanismos inmunopatológicos de enfermedades autoinmunes con especial interes en la enfermedad inflamatoria intestinal. En una segunda línea de trabajo relacionada con la Oncología Cutánea analiza el efecto de elementos genéticos en la predisposición, desarrollo y evolución del melanoma.

Palabras clave

Autoinmunidad Inmunogenetica Enfermedad Inflamatoria Intestinal (IBD) Psoriasis Alopecia Areata Melanoma Carcinoma Baso Celular y Carcinoma Epidermoide Citocinas, quimiocinas HLA TLR, NOD-2, Inflamasoma.

MARIA JOSE CABELLO TAPIA

MIGUEL ANGEL LOPEZ NEVOT

ORCID

Inventores: MIGUEL ANGEL LOPEZ NEVOT,JOSEFA LEON LOPEZ,ANA GILA MEDINA,JOSÉ ANTONIO MUÑOZ GÁMEZ,ROSA QUILES PÉREZ,PALOMA MUÑOZ DE RUEDA,ÁNGEL CARAZO GALLEGO,ESTHER JOSÉ PAVÓN CASTILLERO,ANA BELÉN MARTÍN ÁLVAREZ,FCO JAVIER SALMERON ESCOBAR
Título: POLIMORFISMOS PARA PREDECIR O PRONOSTICAR LA RESPUESTA AL TRATAMIENTO ANTIVIRAL
Código: P201430205

Inventores: JAVIER SALMERÓN ESCOBAR;PALOMA MUÑOZ DE RUEDA;ROSA QUILES PÉREZ;JOSE ANTONIO MUÑOZ GAMEZ;ESTHER JOSÉ PAVÓN CASTILLERO;ANA GILA MEDINA;MIGUEL ANGEL LOPEZ NEVOT;JORGE CASADO RUIZ;ANGELES RUIZ EXTREMERA;ANA BELÉN MARTÍN;ANGEL CARAZO GALLEGO;JOSEFA LEÓN
Título: Mutaciones específicas (L5P; L7P; L15S) en el epítopo inmunodominante VHC-NS3 (aa 1253-1272) frente al HLA-DQB1*0301 provocan una no respuesta al tratamiento antiviral con pegIFN/RBV en pacientes con Hepatitis Crónica C genotipo
Código: P-06781

Inventores: JOSE ANTONIO LOPEZ ESCAMEZ, MIGUEL ANGEL LOPEZ NEVOT, IRENE GAZQUEZ PÉREZ
Título: MÉTODO DE OBTENCIÓN DE DATOS ÚTILES PARA EL DIAGNOSTICO Y PRONÓSTICO DE LA HIPOACUSIA NEUROSENSORIAL
Código: P201132013

Munoz-Herrera, CM; Gutierrez-Bautista, JF; Lopez-Nevot, MA

Clinical Case: Patient with Mixed Graft Rejection Four Days after Kidney Transplantation Developed Specific Antibodies against Donor Bw4 Specificities.

ANTIBODIES, 2021;

Sanchez-Maldonado, JM; Moniz-Diez, A; ter Horst, R; Campa, D; Cabrera-Serrano, AJ; Martinez-Bueno, M; Garrido-Collado, MD; Hernandez-Mohedo, F; Fernandez-Puerta, L; Lopez-Nevot, MA; Cunha, C; Gonzalez-Sierra, PA; Springer, J; Lackner, M; Alcazar-Fuoli, L;

Polymorphisms within the TNFSF4 and MAPKAPK2 Loci Influence the Risk of Developing Invasive Aspergillosis: A Two-Stage Case Control Study in the Context of the aspBIOmics Consortium

JOURNAL OF FUNGI, 2021;

FI:5,816; Q1

Sanchez-Maldonado, JM; Caliz, R; Lopez-Nevot, MA; Cabrera-Serrano, AJ; Moniz-Diez, A; Canhao, H; Ter Horst, R; Quartuccio, L; Sorensen, SB; Glintborg, B; Hetland, ML; Filipescu, I; Perez-Pampin, E; Conesa-Zamora, P; Swierkot, J; den Broeder, AA; De Vita,

Validation of GWAS-Identified Variants for Anti-TNF Drug Response in Rheumatoid Arthritis: A Meta-Analysis of Two Large Cohorts

FRONTIERS IN IMMUNOLOGY, 2021;

FI:7,561; Q1

Montoyo-Pujol, YG; Wang, X; Bermudez-Sanchez, S; Martin, A; Almazan, F; Lopez-Nevot, MA

Measurement of 45 cytokine, chemokine and growth factors in established cell culture supernatants and autologous serum from advanced melanoma patients

CARCINOGENESIS, 2021;

FI:4,944; Q2

Wang, X; Montoyo-Pujol, YG; Bermudez, S; Corpas, G; Martin, A; Almazan, F; Cabrera, T; Lopez-Nevot, MA

Serum Cytokine Profiles of Melanoma Patients and Their Association with Tumor Progression and Metastasis

JOURNAL OF ONCOLOGY, 2021;

FI:4,375; Q2

Sanchez-Maldonado, JM; Campa, D; Springer, J; Badiola, J; Niazi, Y; Moniz-Diez, A; Hernandez-Mohedo, F; Gonzalez-Sierra, P; Ter Horst, R; Macauda, A; Brezina, S; Cunha, C; Lackner, M; Lopez-Nevot, MA; Fianchi, L; Pagano, L; Lopez-Fernandez, E; Potenza, L;

Host immune genetic variations influence the risk of developing acute myeloid leukaemia: results from the NuCLEAR consortium

BLOOD CANCER JOURNAL, 2020;

FI:8,023; D1

Sanchez-Maldonado, JM; Martinez-Bueno, M; Canhao, H; ter Horst, R; Munoz-Pena, S; Moniz-Diez, A; Rodriguez-Ramos, A; Escudero, A; Sorensen, SB; Hetland, ML; Ferrer, MA; Glintborg, B; Filipescu, I; Perez-Pampin, E; Conesa-Zamora, P; Garcia, A; den Broeder,

NFKB2 polymorphisms associate with the risk of developing rheumatoid arthritis and response to TNF inhibitors: Results from the REPAIR consortium

SCIENTIFIC REPORTS, 2020;

FI:3,998; Q1

Lupianez, CB; Martinez-Bueno, M; Sanchez-Maldonado, JM; Badiola, J; Cunha, C; Springer, J; Lackner, M; Segura-Catena, J; Canet, LM; Alcazar-Fuoli, L; Lopez-Nevot, MA; Fianchi, L; Aguado, JM; Pagano, L; Lopez-Fernandez, E; Alarcon-Riquelme, M; Potenza, L;

Polymorphisms within the ARNT2 and CX3CR1 Genes Are Associated with the Risk of Developing Invasive Aspergillosis

INFECTION AND IMMUNITY, 2020;

FI:3,201; Q2

Gamez, CGM; Chamorro, AM; Casares, AMM; Sanchez, JT; Arias-Santiago, S; Garcia-Lora, E; Lopez-Nevot, MA

Joint study of the associations of HLA-B and the transmembrane short tandem repeat polymorphism of MICA protein with alopecia areata shows independent associations of both with the disease

CLINICAL AND EXPERIMENTAL DERMATOLOGY, 2020;

FI:1,977; Q3

Sanchez-Maldonado, JM; Caliz, R; Cana, L; ter Horst, R; Bakker, O; den Broeder, AA; Martinez-Bueno, M; Canhao, H; Rodriguez-Ramos, A; Lupianez, CB; Soto-Pino, MJ; Garcia, A; Perez-Pampin, E; Gonzalez-Utrilla, A; Escudero, LA; Segura-Catena, J; Netea-Maier, RT; Ferrer, MA; Collantes-Estevez, E; Nevot, MAL; Li, Y; Jurado, M; Fonseca, JE; Netea, MG; Coenen, MJH; Sainz, J

Steroid hormone-related polymorphisms associate with the development of bone erosions in rheumatoid arthritis and help to predict disease progression: Results from the REPAIR consortium

SCIENTIFIC REPORTS, 2019;

FI:4,011; Q1

Aliaga, L; Ceballos, J; Sampedro, A; Cobo, F; Lopez-Nevot, MA; Merino-Espinosa, G; Morillas-Marquez, F; Martin-Sanchez, J

Asymptomatic Leishmania infection in blood donors from the Southern of Spain

INFECTION, 2019;

FI:2,927; Q2

Porrino-Bustamante, ML; Lopez-Nevot, MA; Aneiros-Fernandez, J; Casado-Ruiz, J; Garcia-Linares, S; Pedrinacci-Rodriguez, S; Garcia-Lora, E; Martin-Casares, MA; Fernandez-Pugnaire, MA; Arias-Santiago, S

Study of Human Leukocyte Antigen (HLA) in 13 cases of familial frontal fibrosing alopecia: CYP21A2 gene p.V281L mutation from congenital adrenal hyperplasia linked to HLA class I haplotype HLA-A33:01; B14:02; C*08:02 as a genetic marker

AUSTRALASIAN JOURNAL OF DERMATOLOGY, 2019;

FI:1,701; Q3

Porrino-Bustamante, ML; Lopez-Nevot, MA; Aneiros-Fernandez, J; Garcia-Lora, E; Fernandez-Pugnaire, MA; Arias-Santiago, S

Familial frontal fibrosing alopecia: A cross-sectional study of 20 cases from nine families

AUSTRALASIAN JOURNAL OF DERMATOLOGY, 2019;

FI:1,701; Q3

Manosa, M; Calafat, M; de Francisco, R; Garcia, C; Casanova, MJ; Huelin, P; Calvo, M; Tosca, J; Fernandez-Salazar, L; Arajol, C; Zabana, Y; Bastida, G; Hinojosa, J; Marquez, L; Barreiro-De-Acosta, M; Calvet, X; Monfort, D; Gomez-Garcia, MR; Rodriguez, E; Huguet, JM; Rojas-Feria, M; Hervias, D; Atienza, R; Busquets, D; Zapata, E; Duenas, C; Charro, M; Martinez-Cerezo, FJ; Plaza, R; Vazquez, JM; Gisbert, JP; Canete, F; Cabre, E; Domenech, E

Phenotype and natural history of elderly onset inflammatory bowel disease: a multicentre, case-control study

ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 2018;

FI:7,357; D1

Martinez-Lopez, A; Blasco-Morente, G; Perez-Lopez, I; Tercedor-Sanchez, J; Arias-Santiago, S

Studying the effect of systemic and biological drugs on intima-media thickness in patients suffering from moderate and severe psoriasis

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY, 2018;

FI:4,287; Q1

Casanova, MJ; Chaparro, M; Garcia-Sanchez, V; Nantes, O; Leo, E; Rojas-Feria, M; Jauregui-Amezaga, A; Garcia-Lopez, S; Huguet, JM; Arguelles-Arias, F; Aicart, M; Marin-Jimenez, I; Gomez-Garcia, M; Munoz, F; Esteve, M; Bujanda, L; Cortes, X; Tosca, J; Pineda, JR; Manosa, M; Llao, J; Guardiola, J; Perez-Martinez, I; Munoz, C; Gonzalez-Lama, Y; Hinojosa, J; Vazquez, JM; Martinez-Montiel, MP; Rodriguez, GE; Pajares, R; Garcia-Sepulcre, MF; Hernandez-Martinez, A; Perez-Calle, JL; Beltran, B; Busquets, D; Ramos, L; Bermejo, F; Barrio, J; Barreiro-de Acosta, M; Roncedo, O; Calvet, X; Hervias, D; Gomollon, F; Dominguez-Antonaya, M; Alcain, G; Sicilia, B; Duenas, C; Gutierrez, A; Lorente-Poyatos, R; Dominguez, M; Khorrami, S; Munoz, C; Taxonera, C; Rodriguez-Perez, A; Ponferrada, A; Van Domselaar, M; Arias-Rivera, ML; Merino, O; Castro, E; Marrero, JM; Martin-Arranz, M; Botella, B; Fernandez-Salazar, L; Monfort, D; Opio, V; Garcia-Herola, A; Menacho, M; Ramirez-de La Piscina, P; Ceballos, D; Almela, P; Navarro-Llavat, M; Robles-Alonso, V; Vega-Lopez, AB; Moraleja, I; Novella, MT; Castano-Milla, C; Sanchez-Torres, A; Benitez, JM; Rodriguez, C; Castro, L; Garrido, E; Domenech, E; Garcia-Planella, E; Gisbert, JP

Evolution After Anti-TNF Discontinuation in Patients With Inflammatory Bowel Disease: A Multicenter Long-Term Follow-Up Study

AMERICAN JOURNAL OF GASTROENTEROLOGY, 2017;

FI:9,566; D1

Martinez-Lopez, A; Blasco-Morente, G; Perez-Lopez, I; Herrera-Garcia, JD; Luque-Valenzuela, M; Sanchez-Cano, D; Lopez-Gutierrez, JC; Ruiz-Villaverde, R; Tercedor-Sanchez, J

CLOVES syndrome: review of a PIK3CA-related overgrowth spectrum (PROS)

CLINICAL GENETICS, 2017;

FI:3,326; Q2

Ruiz-Villaverde, R; Bueno-Rodriguez, A; Tercedor-Sanchez, J

Apremilast, beyond psoriasis as a therapeutic target

MEDICINA CLINICA, 2017;

FI:1,125; Q3

Perez-Lopez, I; Martinez-Lopez, A; Blasco-Morente, G; Ruiz-Villaverde, R; Tercedor-Sanchez, J

Is it safe to use N-acetylcysteinein the treatment of bilateralectropion on collodion baby?

INTERNATIONAL JOURNAL OF DERMATOLOGY, 2017;

FI:1,56; Q3

Martinez-Lopez, A; Blasco-Morente, G; Perez-Lopez, I; Naranjo-Diaz, MJ; Aneiros-Fernandez, J; Ruiz-Villaverde, R; Tercedor-Sanchez, J

Successful treatment of proliferative verrucous leukoplakia with 5% topical imiquimod

DERMATOLOGIC THERAPY, 2017;

FI:1,093; Q4

Taxonera, C; Barreiro-de-Acosta, M; Bastida, G; Martinez-Gonzalez, J; Merino, O; Garcia-Sanchez, V; Gisbert, JP; Marin-Jimenez, I; Lopez-Serrano, P; Gomez-Garcia, M; Iglesias, E; Lopez-Sanroman, A; Chaparro, M; Saro, C; Bermejo, F; Perez-Carazo, L; Plaza, R; Olivares, D; Alba, C; Mendoza, JL; Fernandez-Blanco, I

Outcomes of Medical and Surgical Therapy for Entero-urinary Fistulas in Crohn’s Disease

JOURNAL OF CROHNS & COLITIS, 2016;

FI:6,585; D1

Stephens, C; Moreno-Casares, A; Lopez-Nevot, MA; Garcia-Cortes, M; Medina-Caliz, I; Hallal, H; Soriano, G; Roman, E; Ruiz-Cabello, F; Romero-Gomez, M; Lucena, MI; Andrade, RJ

Killer Immunoglobulin-Like Receptor Profiles Are not Associated with Risk of Amoxicillin-Clavulanate-Induced Liver Injury in Spanish Patients

FRONTIERS IN PHARMACOLOGY, 2016;

FI:4,418; Q1

Lupianez, CB; Canet, LM; Carvalho, A; Alcazar-Fuoli, L; Springer, J; Lackner, M; Segura-Catena, J; Comino, A; Olmedo, C; Rios, R; Fernandez-Montoya, A; Cuenca-Estrella, M; Solano, C; Lopez-Nevot, MA; Cunha, C; Oliveira-Coelho, A; Villaescusa, T; Fianchi, L; Aguado, JM; Pagano, L; Lopez-Fernandez, E; Potenza, L; Luppi, M; Lass-Florl, C; Loeffler, J; Einsele, H; Vazquez, L; Jurado, M; Sainz, J

Polymorphisms in Host Immunity-Modulating Genes and Risk of Invasive Aspergillosis: Results from the AspBIOmics Consortium

INFECTION AND IMMUNITY, 2016;

FI:3,603; Q1

Encarnacion, MC; Palomino-Morales, RJ; Fuchs, JE; Esperanza, PG; Noel, MT; Salido, E; Timson, DJ; Pey, AL

Conformational dynamics is key to understanding loss-of-function of NQO1 cancer-associated polymorphisms and its correction by pharmacological ligands

SCIENTIFIC REPORTS, 2016;

FI:5,228; Q1

Martinez-Chamorro, A; Moreno, A; Gomez-Garcia, M; Cabello, MJ; Martin, J; Lopez-Nevot, MA

MICAA4 protects against ulcerative colitis, whereas MICAA5.1 is associated with abscess formation and age of onset

CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2016;

FI:3,148; Q2

Ramos, JL; Cuenca, MS; Molina-Santiago, C; Segura, A; Duque, E; Gomez-Garcia, MR; Udaondo, Z; Roca, A

Mechanisms of solvent resistance mediated by interplay of cellular factors in Pseudomonas putida

FEMS MICROBIOLOGY REVIEWS, 2015;

FI:13,244; D1

Canet, LM; Caliz, R; Lupianez, CB; Canhao, H; Martinez, M; Escudero, A; Filipescu, I; Segura-Catena, J; Soto-Pino, MJ; Ferrer, MA; Garcia, A; Romani, L; Perez-Pampin, E; Gonzalez-Utrilla, A; Lopez Nevot, MA; Collantes, E; Fonseca, JE; Sainz, J

Genetic variants within immune-modulating genes influence the risk of developing rheumatoid arthritis and anti-TNF drug response: a two-stage case-control study

PHARMACOGENETICS AND GENOMICS, 2015;

FI:3,481; Q1

Canet, LM; Filipescu, I; Caliz, R; Lupianez, CB; Canhao, H; Escudero, A; Segura-Catena, J; Soto-Pino, MJ; Ferrer, MA; Garcia, A; Romani, L; Perez-Pampin, E; Gonzalez-Utrilla, A; Nevot, MAL; Collantes, E; Fonseca, JE; Sainz, J

Genetic variants within the TNFRSF1B gene and susceptibility to rheumatoid arthritis and response to anti-TNF drugs: a multicenter study

PHARMACOGENETICS AND GENOMICS, 2015;

FI:3,481; Q1

Moreno-Rincon, E; Benitez, JM; Serrano-Ruiz, FJ; Vazquez-Moron, JM; Pallares-Manrique, H; Herrera-Justiniano, JM; Leo-Carnerero, E; Gomez-Garcia, MR; Cabello-Tapia, MJ; Castro-Fernandez, M; Rojas-Feria, M; Castro-Laria, L; Arguelles-Arias, F; Camargo-Camero, R; Alcain-Martinez, G; Iglesias-Flores, E; Garcia-Sanchez, V

Prognosis of Patients with Ulcerative Colitis in Sustained Remission After Thiopurines Withdrawal

INFLAMMATORY BOWEL DISEASES, 2015;

FI:4,464; Q1

Ortiz-Fernandez, L; Garcia-Lozano, JR; Montes-Cano, MA; Conde-Jaldon, M; Leo, E; Ortego-Centeno, N; Gomez-Garcia, M; Garcia-Hernandez, FJ; Marquez, JL; Espinosa, G; Grana-Gil, G; Sanchez-Burson, J; Julia, MR; Blanco, R; Barnosi-Marin, AC; Solans, R; Fanlo, P; Rodriguez-Carballeira, M; Camps, T; Castaneda, S; Martin, J; Gonzalez-Escribano, MF

Association of haplotypes of the TLR8 locus with susceptibility to Crohn’s and Behcet’s diseases

CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, 2015;

FI:2,724; Q2

TOFACITINIB IN ULCERATIVE COLITIS: REAL WORLD EVIDENCE (To-ReWard Study)

Financiador: PÉREZ GISBERT, JAVIER

Tipo de prueba: ESTUDIO POSAUTORIZACION INDEPENDIENTE

Tiempo de ejecución: 24/06/2021 - 30/03/2022

IP: MARIA JOSE CABELLO TAPIA

A phase 2b, double-blind, randomized, placebo-controlled, parallel group, dose ranging study of oral PF-06651600 and PF-06700841 as induction and chronic therapy in subjects with moderate to severe uncerative colitis

Financiador: PFIZER INC

Tipo de prueba: ENSAYO CLINICO COMERCIAL

Tiempo de ejecución: 26/09/2017 - 30/09/2020

IP: MARIA JOSE CABELLO TAPIA

Estudio en fase IIA aleatorizado, doble ciego, controlado con placebo, de grupos paralelos, para evaluar la eficacia y la seguridad de PF-06651600 y PF06700841 por via oral como tratamiento de induccion y de extension abierta en pacientes con Enfermedad de Crohn moderada o grave

Financiador: PFIZER INC

Tipo de prueba: ENSAYO CLINICO COMERCIAL

Tiempo de ejecución: 27/06/2018 - 28/02/2021

IP: MARIA JOSE CABELLO TAPIA

Estudio de busqueda de dosis de fase II,multicentrico, aleatorizado, doble ciego, controlado por placebo para evaluar la eficacia y la seguridad de IMU-838 en terapia de induccion y mantenimiento en colitis ulcerosa de moderada a grave. CALDOSE I

Financiador: IMMUNIC AG

Tipo de prueba: ENSAYO CLINICO COMERCIAL

Tiempo de ejecución: 30/05/2018 - 22/01/2020

IP: MARIA JOSE CABELLO TAPIA

MP04-Inmunogenética Enfermedades Sistémicas y Cutáneas

Palabras clave

MARIA JOSE CABELLO TAPIA

MIGUEL ANGEL LOPEZ NEVOT

Investigación