Tailored Exercise Interventions for Dementia prevention: bridging research evidence and primary care practice.
The primary aim of the TEIDe Project is to identify individuals at high risk of dementia and to enhance understanding of the interplay between exercise and cognitive aging. To achieve this, the TEIDe consortium will establish an integrated framework combining predictive, precision, mechanistic, and clinical application approaches for the effective prevention of dementia. The four main project research questions focus on:
(i) the discriminative power of dementia risk scores;
(ii) the optimal types and doses of exercise that confer cognitive benefits based on individual patient characteristics;
(iii) the underlying mechanisms of the effect of exercise on cognition; and
(iv) the feasibility of implementing a holistic approach in primary healthcare settings.
To address these research questions, data are leveraged from existing cohort studies, including over 3 million individuals, and from seven completed, rigorously conducted exercise-based randomized controlled trials (RCTs) in middle-aged and older adults with a range of cognitive functions. With nine partners from eight countries (i.e., Spain, Norway, Germany, Italy, Slovakia, Romania, the USA, and Canada), the consortium integrates academia, healthcare, enterprise, and operational stakeholders. This project will generate at least four products that can be implemented in healthcare systems in the relatively short term: (i) dementia risk scores, (ii) exercise prescription algorithms, (iii) user-friendly exercise manuals, and (iv) modifiable risk factors for non-pharmaceutical treatment.
The deliverables will benefit patients and clinicians, contributing to the prevention of cognitive decline and early-stage Alzheimer´s disease, promoting personalized medicine in dementia care. The TEIDe project stands as a collaborative effort to advance world-class research and strengthen research links, paving the way for improved prediction of treatment benefits and personalized interventions.
- Funder: European Commission
- Project ID: HOR-2025-03
- Principal Investigator: Irene Esteban Cornejo
- Group: TEC15 – MEDICINA NUCLEAR Y MOLECULAR
- Center: University of Granada
- Rol in the project: Coordinator
- Duration: 2025-2028