TEC12-Salud Materno Fetal y Elastografía

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Ensayos clínicos

The structural microarchitecture of soft tissue is recently becoming a cornerstone of biomechanical engineering and is of growing interest for a broad spectrum of clinical specialists. Our new ultrasonic wave concepts are enabling a new class of biomarkers for both imaging and controlling in vivo and noninvasively tissue microarchitecture. The breakthrough of modelling its elastic hierarchical complexity impacts critical aspects including organ-level functionality, inflammatory and healing processes, tumour growth, all the way down to cell-to-cell signalling. We have: a) Conceived and developed torsional ultrasonic waves and sensor technologies capable of generating and sensing them, prototyping robust functional instrumentation. b) Modelled relationships between the biochemical cascade and the mechanical functionality and their interaction with ultrasound, integrating models of tissue remodelling and tumour growth, experimentally validated by ultrasonication of cancer stem cells.

Líneas de investigación

Biomecánica y ensayos mecánicos de tejidos
Biorreactores sensorizados
Dispositivos médicos de diagnóstico por ultrasonidos y elastografía - aplicación a parto pretérmino
Ecografía elastográfica y de ultra-alta velocidad
Inferencia estadística, inteligencia artificial, pronóstico, decisiones, imagen
Modelos computacionales biomecánicos - elementos finitos

Redes de investigación

Red Española de Investigación en Biomecánica

Palabras clave

Ultrasonidos, Ecografía, Ginecología, Elastografía, Biomecánica, Ensayos mecánicos, Ginecología, Oncología, Ondas, Biorreactores.

YOUSEF ALMASHAKBEH SALEH

PARISA REZAEIAFARAPOLI

ORCID

HIRAD SHAMIMI NOORI

OLGA OCON HERNANDEZ

CARMEN PADILLA VINUESA

MIGUEL ANGEL RIVEIRO TABOADA

GUILLERMO RUS CALBORG

JORGE TORRES PEREZ

ANTONIO GOMEZ FERNANDEZ

OTILIA RUTH GONZALEZ VANEGAS

ORCID

INAS H FARIS

ORCID

MANUEL HURTADO ESTEVEZ

ORCID

JUAN MANUEL MELCHOR RODRIGUEZ

ORCID

FRANCISCA SONIA MOLINA GARCIA

ORCID

IPR-678 - Biorreactor ultrasónico de baja frecuencia como terapia selectiva frente a cáncer.

P201630123 - Procedimiento de obtención de datos sobre la elasticidad de materiales empleando ondas de torsión

PCT/ES2016/070540 + P201500600 - Dispositivo emisor de ondas ultrasónicas de torsión y transductor que lo comprende.

P201730415 - Dispositivo transluminal y procedimiento para la caracterización mecánica de estructuras.

Peinado, FM; Lendinez, I; Sotelo, R; Iribarne-Duran, LM; Fernandez-Parra, J; Vela-Soria, F; Olea, N; Fernandez, MF; Freire, C; Leon, J; Perez-Cabrera, B; Ocon-Hernandez, O; Artacho-Cordon, F

Association of Urinary Levels of Bisphenols A, F, and S with Endometriosis Risk: Preliminary Results of the EndEA Study

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, 2020;

Alvarez-Salvago, F; Lara-Ramos, A; Cantarero-Villanueva, I; Mazheika, M; Mundo-Lopez, A; Galiano-Castillo, N; Fernandez-Lao, C; Arroyo-Morales, M; Ocon-Hernandez, O; Artacho-Cordon, F

Chronic Fatigue, Physical Impairments and Quality of Life in Women with Endometriosis: A Case-Control Study

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, 2020;

Masso, P; Melchor, J; Rus, G; Molina, FS

A Preliminary Study on the Safety of Elastography during Pregnancy: Hypoacusia, Anthropometry, and Apgar Score in Newborns

DIAGNOSTICS, 2020;

FI:3,11; Q1

Yazdi, AA; Melchor, J; Torres, J; Faris, I; Callejas, A; Gonzalez-Andrades, M; Rus, G

Characterization of non-linear mechanical behavior of the cornea

SCIENTIFIC REPORTS, 2020;

FI:3,998; Q1

Baena-Garcia, L; Coll-Risco, I; Ocon-Hernadez, O; Romero-Gallardo, L; Acosta-Manzano, P; May, L; Aparicio, VA

Association of objectively measured physical fitness during pregnancy with maternal and neonatal outcomes. The GESTAFIT Project

PLOS ONE, 2020;

FI:2,74; Q2

Mustieles, V; Casas, M; Ferrando-Marco, P; Ocon-Hernandez, O; Reina-Perez, I; Rodriguez-Carrillo, A; Vela-Soria, F; Perez-Lobato, R; Navarrete-Munoz, EM; Freire, C; Olea, N; Fernandez, MF

Bisphenol A and adiposity measures in peripubertal boys from the INMA-Granada cohort

ENVIRONMENTAL RESEARCH, 2019;

FI:5,026; D1

Callejas, A; Rus, G

Experimental Configuration to Determine the Nonlinear Parameter in PMMA and CFRP with the Finite Amplitude Method

SENSORS, 2019;

FI:3,031; Q1

Masso, P; Callejas, A; Melchor, J; Molina, FS; Rus, G

In Vivo Measurement of Cervical Elasticity on Pregnant Women by Torsional Wave Technique: A Preliminary Study

SENSORS, 2019;

FI:3,031; Q1

Baena-Garcia, L; Ocon-Hernandez, O; Acosta-Manzano, P; Coll-Risco, I; Borges-Cosic, M; Romero-Gallardo, L; de la Flor-Alemany, M; Aparicio, VA

Association of sedentary time and physical activity during pregnancy with maternal and neonatal birth outcomes. The GESTAFIT Project

SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS, 2019;

FI:3,631; Q1

Plaza-Diaz, J; Gomez-Fernandez, A; Chueca, N; de la Torre-Aguilar, MJ; Gil, A; Perez-Navero, JL; Flores-Rojas, K; Martin-Borreguero, P; Solis-Urra, P; Ruiz-Ojeda, FJ; Garcia, F; Gil-Campos, M

Autism Spectrum Disorder (ASD) with and without Mental Regression Is Associated with Changes in the Fecal Microbiota

NUTRIENTS, 2019;

FI:4,171; Q1

Melchor, J; Lopez-Ruiz, E; Soto, J; Jimenez, G; Antich, C; Peran, M; Baena, JM; Marchal, JA; Rus, G

In-bioreactor ultrasonic monitoring of 3D culture human engineered cartilage

SENSORS AND ACTUATORS B-CHEMICAL, 2018;

FI:5,667; D1

Tan, MY; Poon, LC; Rolnik, DL; Syngelaki, A; Matallana, CD; Akolekar, R; Cicero, S; Janga, D; Singh, M; Molina, FS; Persico, N; Jani, JC; Plasencia, W; Greco, E; Papaioannou, G; Wright, D; Nicolaides, KH

Prediction and prevention of small-for-gestational-age neonates: evidence from SPREE and ASPRE

ULTRASOUND IN OBSTETRICS & GYNECOLOGY, 2018;

FI:5,654; D1

Tan, MY; Syngelaki, A; Poon, LC; Rolnik, DL; O'Gorman, N; Delgado, JL; Akolekar, R; Konstantinidou, L; Tsavdaridou, M; Galeva, S; Ajdacka, U; Molina, FS; Persico, N; Jani, JC; Plasencia, W; Greco, E; Papaioannou, G; Wright, A; Wright, D; Nicolaides, KH

Screening for pre-eclampsia by maternal factors and biomarkers at 11-13 weeks’ gestation

ULTRASOUND IN OBSTETRICS & GYNECOLOGY, 2018;

FI:5,654; D1

Wright, D; Rolnik, DL; Syngelaki, A; Matallana, CD; Machuca, M; de Alvarado, M; Mastrodima, S; Tan, MY; Shearing, S; Persico, N; Jani, JC; Plasencia, W; Papaioannou, G; Molina, FS; Poon, LC; Nicolaides, KH

Aspirin for Evidence-Based Preeclampsia Prevention trial: effect of aspirin on length of stay in the neonatal intensive care unit

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 2018;

FI:5,732; D1

Rus, G; Melchor, J

Logical Inference Framework for Experimental Design of Mechanical Characterization Procedures

SENSORS, 2018;

FI:2,475; Q1

Masso, P; Rus, G; Molina, FS

Safety of elastography in fetal medicine: preliminary study on hypoacusis

ULTRASOUND IN OBSTETRICS & GYNECOLOGY, 2017;

FI:4,71; D1

Peralta, L; Molina, FS; Melchor, J; Gomez, LF; Masso, P; Florido, J; Rus, G

Transient Elastography to Assess the Cervical Ripening during Pregnancy: A Preliminary Study

ULTRASCHALL IN DER MEDIZIN, 2017;

FI:3,892; D1

O'Gorman, N; Wright, D; Poon, LC; Rolnik, DL; Syngelaki, A; Wright, A; Akolekar, R; Cicero, S; Janga, D; Jani, J; Molina, FS; Matallana, CDP; Papantoniou, N; Persico, N; Plasencia, W; Singh, M; Nicolaides, KH

Accuracy of competing-risks model in screening for pre-eclampsia by maternal factors and biomarkers at 11-13 weeks’ gestation

ULTRASOUND IN OBSTETRICS & GYNECOLOGY, 2017;

FI:4,71; D1

Rolnik, DL; Wright, D; Poon, LCY; Syngelaki, A; O'Gorman, N; Matallana, CD; Akolekar, R; Cicero, S; Janga, D; Singh, M; Molina, FS; Persico, N; Jani, JC; Plasencia, W; Papaioannou, G; Tenenbaum-Gavish, K; Nicolaides, KH

ASPRE trial: performance of screening for preterm pre-eclampsia

ULTRASOUND IN OBSTETRICS & GYNECOLOGY, 2017;

FI:4,71; D1

Rolnik, DL; Wright, D; Poon, LC; O'Gorman, N; Syngelaki, A; Matallana, CD; Akolekar, R; Cicero, S; Janga, D; Singh, M; Molina, FS; Persico, N; Jani, JC; Plasencia, W; Papaioannou, G; Tenenbaum-Gavish, K; Meiri, H; Gizurarson, S; Maclagan, K; Nicolaides, KH

Aspirin versus Placebo in Pregnancies at High Risk for Preterm Preeclampsia

NEW ENGLAND JOURNAL OF MEDICINE, 2017;

FI:72,406; D1

Ben-Ami, I; Molina, FS; Battino, S; Daniel-Spiegel, E; Melcer, Y; Flock, A; Geipel, A; Odeh, M; Miron, P; Maymon, R

Monochorionic diamniotic in vitro fertilization twins have a decreased incidence of twin-to-twin transfusion syndrome

FERTILITY AND STERILITY, 2016;

FI:4,426; D1

Nicolaides, KH; Syngelaki, A; Poon, LC; Matallana, CD; Plasencia, W; Molina, FS; Picciarelli, G; Tul, N; Celik, E; Lau, TK; Conturso, R

Cervical pessary placement for prevention of preterm birth in unselected twin pregnancies: a randomized controlled trial

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 2016;

FI:4,681; D1

Maiz, N; Alonso, I; Belar, M; Burgos, J; Irasarri, A; Molina, FS; de Paco, C; Pijoan, JI; Plasencia, W; Rodo, C; Rodriguez, MA; Tajada, M; Tubau, A

Three dimensional ultrasonography for advanced neurosonography (Neurosofe-3d). Analysis of acquisition-related factors influencing the quality of the brain volumes

PRENATAL DIAGNOSIS, 2016;

FI:3,043; Q1

Messineo, MG; Rus, G; Elicabe, GE; Frontini, GL

Layered material characterization using ultrasonic transmission. An inverse estimation methodology

ULTRASONICS, 2016;

FI:1,954; Q1

Martino, J; Sebert, S; Segura, MT; Garcia-Valdes, L; Florido, J; Padilla, MC; Marcos, A; Rueda, R; McArdle, HJ; Budge, H; Symonds, ME; Campoy, C

Maternal Body Weight and Gestational Diabetes Differentially Influence Placental and Pregnancy Outcomes

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2016;

FI:5,531; Q1

Síntesis de magnetoliposomas que contienen nanoburbujas para la liberación del fármaco mediante estimulación remota dual

Financiador: AGENCIA ESTATAL DE INVESTIGACIÓN

Número de expediente: PID2019-106947RA-C22

Tiempo de ejecución: 01/06/2020 - 31/05/2023

IP: JUAN MANUEL MELCHOR RODRIGUEZ

Dispositivo de diagnóstico de cáncer de próstata por ondas mecánicas.

Financiador: FUNDACIÓN PÚBLICA PARA LA INVESTIGACIÓN BIOSANITARIA DE ANDALUCIA ORIENTAL ALEJANDRO OTERO (FIBAO)

Número de expediente: INB-0010

Tiempo de ejecución: 10/06/2017 - 09/06/2019

IP: GUILLERMO RUS CALBORG

PI16/00339 PREDICCIÓN DEL PARTO POR ELASTOGRAFÍA ULTRASÓNICA

Financiador: INSTITUTO DE SALUD CARLOS III

Número de expediente: PI16/00339

Tiempo de ejecución: 01/01/2017 - 31/12/2019

IP: FRANCISCA SONIA MOLINA GARCIA

Ultrasonidos de Torsión para Diagnóstico de Parto Pretérmino y Predicción del Éxito en la Inducción.

Financiador: CONSEJERÍA DE SALUD

Número de expediente: PI-0107-2017

Tiempo de ejecución: 01/01/2018 - 31/12/2020

IP: JUAN MANUEL MELCHOR RODRIGUEZ

Dispositivo para Predicción de Parto Mediante el Desarrollo Tecnológico de Un Sensor Ultrasónico de Torsión.

Financiador: CONSEJERÍA DE SALUD

Número de expediente: PIN-0030-2017

Tiempo de ejecución: 01/01/2018 - 31/12/2020

IP: Dispositivo para Predicción de Parto Mediante el Desarrollo Tecnológico de Un Sensor Ultrasónico de Torsión.

Impacto de la detección y tratamiento precoz de las gestantes portadoras asintomáticas de vaginosis bacteriana, en la tasa de parto pretérmino (VB-PREM)

Financiador: INSTITUTO DE SALUD CARLOS III

Número de expediente: PI17/01881

Tiempo de ejecución: 01/01/2018 - 31/12/2020

IP: OTILIA RUTH GONZALEZ VANEGAS

Desarrollo de un algoritmo diagnóstico de Amenaza de Parto Pretérmino que integra variables clínicas y la cuantificación de la consistencia cervical utilizando el dispositivo Fine Birth

Financiador: ULTRASOUND-INNOVATION MEDTECH, S.L.

Tipo de prueba: INV. CLINICA PRODUCTO SANITARIO COM.

Tiempo de ejecución: 05/11/2020 - 30/06/2021

IP: FRANCISCA SONIA MOLINA GARCIA

TEC12-Salud Materno Fetal y Elastografía

Líneas de investigación

Redes de investigación

Palabras clave

YOUSEF ALMASHAKBEH SALEH

PARISA REZAEIAFARAPOLI

HIRAD SHAMIMI NOORI

OLGA OCON HERNANDEZ

CARMEN PADILLA VINUESA

MIGUEL ANGEL RIVEIRO TABOADA

GUILLERMO RUS CALBORG

JORGE TORRES PEREZ

BEATRIZ BLANCO BESTEIRO

ANTONIO CALLEJAS ZAFRA

PILAR CARRETERO LUCENA

ANTONIO GOMEZ FERNANDEZ

OTILIA RUTH GONZALEZ VANEGAS

INAS H FARIS

MANUEL HURTADO ESTEVEZ

JUAN MANUEL MELCHOR RODRIGUEZ

FRANCISCA SONIA MOLINA GARCIA

Investigación