TEC12-Biomecánica
Terapias avanzadas y Tecnologías Biomédicas / IBS-TEC12
The structural microarchitecture of soft tissue is recently becoming a cornerstone of biomechanical engineering and is of growing interest for a broad spectrum of clinical specialists. Our new ultrasonic wave concepts are enabling a new class of biomarkers for both imaging and controlling in vivo and noninvasively tissue microarchitecture. The breakthrough of modelling its elastic hierarchical complexity impacts critical aspects including organ-level functionality, inflammatory and healing processes, tumour growth, all the way down to cell-to-cell signalling. We have: a) Conceived and developed torsional ultrasonic waves and sensor technologies capable of generating and sensing them, prototyping robust functional instrumentation. b) Modelled relationships between the biochemical cascade and the mechanical functionality and their interaction with ultrasound, integrating models of tissue remodelling and tumour growth, experimentally validated by ultrasonication of cancer stem cells.
Líneas de investigación
- Biomecánica y ensayos mecánicos de tejidos
- Biorreactores sensorizados
- Dispositivos médicos de diagnóstico por ultrasonidos y elastografía - aplicación a parto pretérmino
- Ecografía elastográfica y de ultra-alta velocidad
- Inferencia estadística, inteligencia artificial, pronóstico, decisiones, imagen
- Modelos computacionales biomecánicos - elementos finitos
Palabras clave
Ultrasonidos, Ecografía, Ginecología, Elastografía, Biomecánica, Ensayos mecánicos, Ginecología, Oncología, Ondas, Biorreactores.
YOUSEF ALMASHAKBEH SALEH
PARISA REZAEIAFARAPOLI
HIRAD SHAMIMI NOORI
OLGA OCON HERNANDEZ
CARMEN PADILLA VINUESA
MIGUEL ANGEL RIVEIRO TABOADA
GUILLERMO RUS CALBORG
JORGE TORRES PEREZ
BEATRIZ BLANCO BESTEIRO
ANTONIO CALLEJAS ZAFRA
PILAR CARRETERO LUCENA
ANTONIO GOMEZ FERNANDEZ
OTILIA RUTH GONZALEZ VANEGAS
INAS H FARIS
MANUEL HURTADO ESTEVEZ
JUAN MANUEL MELCHOR RODRIGUEZ
FRANCISCA SONIA MOLINA GARCIA
Association of Urinary Levels of Bisphenols A, F, and S with Endometriosis Risk: Preliminary Results of the EndEA Study
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, 2020;
Chronic Fatigue, Physical Impairments and Quality of Life in Women with Endometriosis: A Case-Control Study
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, 2020;
A Preliminary Study on the Safety of Elastography during Pregnancy: Hypoacusia, Anthropometry, and Apgar Score in Newborns
DIAGNOSTICS, 2020;
FI:3,11; Q1
Characterization of non-linear mechanical behavior of the cornea
SCIENTIFIC REPORTS, 2020;
FI:3,998; Q1
Association of objectively measured physical fitness during pregnancy with maternal and neonatal outcomes. The GESTAFIT Project
PLOS ONE, 2020;
FI:2,74; Q2
Bisphenol A and adiposity measures in peripubertal boys from the INMA-Granada cohort
ENVIRONMENTAL RESEARCH, 2019;
FI:5,026; D1
Experimental Configuration to Determine the Nonlinear Parameter in PMMA and CFRP with the Finite Amplitude Method
SENSORS, 2019;
FI:3,031; Q1
In Vivo Measurement of Cervical Elasticity on Pregnant Women by Torsional Wave Technique: A Preliminary Study
SENSORS, 2019;
FI:3,031; Q1
Association of sedentary time and physical activity during pregnancy with maternal and neonatal birth outcomes. The GESTAFIT Project
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS, 2019;
FI:3,631; Q1
Autism Spectrum Disorder (ASD) with and without Mental Regression Is Associated with Changes in the Fecal Microbiota
NUTRIENTS, 2019;
FI:4,171; Q1
In-bioreactor ultrasonic monitoring of 3D culture human engineered cartilage
SENSORS AND ACTUATORS B-CHEMICAL, 2018;
FI:5,667; D1
Prediction and prevention of small-for-gestational-age neonates: evidence from SPREE and ASPRE
ULTRASOUND IN OBSTETRICS & GYNECOLOGY, 2018;
FI:5,654; D1
Screening for pre-eclampsia by maternal factors and biomarkers at 11-13 weeks’ gestation
ULTRASOUND IN OBSTETRICS & GYNECOLOGY, 2018;
FI:5,654; D1
Aspirin for Evidence-Based Preeclampsia Prevention trial: effect of aspirin on length of stay in the neonatal intensive care unit
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 2018;
FI:5,732; D1
Logical Inference Framework for Experimental Design of Mechanical Characterization Procedures
SENSORS, 2018;
FI:2,475; Q1
Safety of elastography in fetal medicine: preliminary study on hypoacusis
ULTRASOUND IN OBSTETRICS & GYNECOLOGY, 2017;
FI:4,71; D1
Transient Elastography to Assess the Cervical Ripening during Pregnancy: A Preliminary Study
ULTRASCHALL IN DER MEDIZIN, 2017;
FI:3,892; D1
Accuracy of competing-risks model in screening for pre-eclampsia by maternal factors and biomarkers at 11-13 weeks’ gestation
ULTRASOUND IN OBSTETRICS & GYNECOLOGY, 2017;
FI:4,71; D1
ASPRE trial: performance of screening for preterm pre-eclampsia
ULTRASOUND IN OBSTETRICS & GYNECOLOGY, 2017;
FI:4,71; D1
Aspirin versus Placebo in Pregnancies at High Risk for Preterm Preeclampsia
NEW ENGLAND JOURNAL OF MEDICINE, 2017;
FI:72,406; D1
Monochorionic diamniotic in vitro fertilization twins have a decreased incidence of twin-to-twin transfusion syndrome
FERTILITY AND STERILITY, 2016;
FI:4,426; D1
Cervical pessary placement for prevention of preterm birth in unselected twin pregnancies: a randomized controlled trial
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 2016;
FI:4,681; D1
Three dimensional ultrasonography for advanced neurosonography (Neurosofe-3d). Analysis of acquisition-related factors influencing the quality of the brain volumes
PRENATAL DIAGNOSIS, 2016;
FI:3,043; Q1
Layered material characterization using ultrasonic transmission. An inverse estimation methodology
ULTRASONICS, 2016;
FI:1,954; Q1
Maternal Body Weight and Gestational Diabetes Differentially Influence Placental and Pregnancy Outcomes
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2016;
FI:5,531; Q1
Síntesis de magnetoliposomas que contienen nanoburbujas para la liberación del fármaco mediante estimulación remota dual
Financiador: AGENCIA ESTATAL DE INVESTIGACIÓN
Número de expediente: PID2019-106947RA-C22
Tiempo de ejecución: 01/06/2020 - 31/05/2023
IP: JUAN MANUEL MELCHOR RODRIGUEZ
Dispositivo de diagnóstico de cáncer de próstata por ondas mecánicas.
Financiador: FUNDACIÓN PÚBLICA PARA LA INVESTIGACIÓN BIOSANITARIA DE ANDALUCIA ORIENTAL ALEJANDRO OTERO (FIBAO)
Número de expediente: INB-0010
Tiempo de ejecución: 10/06/2017 - 09/06/2019
IP: GUILLERMO RUS CALBORG
PI16/00339 PREDICCIÓN DEL PARTO POR ELASTOGRAFÍA ULTRASÓNICA
Financiador: INSTITUTO DE SALUD CARLOS III
Número de expediente: PI16/00339
Tiempo de ejecución: 01/01/2017 - 31/12/2019
IP: FRANCISCA SONIA MOLINA GARCIA
Ultrasonidos de Torsión para Diagnóstico de Parto Pretérmino y Predicción del Éxito en la Inducción.
Financiador: CONSEJERÍA DE SALUD
Número de expediente: PI-0107-2017
Tiempo de ejecución: 01/01/2018 - 31/12/2020
IP: JUAN MANUEL MELCHOR RODRIGUEZ
Dispositivo para Predicción de Parto Mediante el Desarrollo Tecnológico de Un Sensor Ultrasónico de Torsión.
Financiador: CONSEJERÍA DE SALUD
Número de expediente: PIN-0030-2017
Tiempo de ejecución: 01/01/2018 - 31/12/2020
IP: Dispositivo para Predicción de Parto Mediante el Desarrollo Tecnológico de Un Sensor Ultrasónico de Torsión.
Impacto de la detección y tratamiento precoz de las gestantes portadoras asintomáticas de vaginosis bacteriana, en la tasa de parto pretérmino (VB-PREM)
Financiador: INSTITUTO DE SALUD CARLOS III
Número de expediente: PI17/01881
Tiempo de ejecución: 01/01/2018 - 31/12/2020
IP: OTILIA RUTH GONZALEZ VANEGAS
Desarrollo de un algoritmo diagnóstico de Amenaza de Parto Pretérmino que integra variables clínicas y la cuantificación de la consistencia cervical utilizando el dispositivo Fine Birth
Financiador: ULTRASOUND-INNOVATION MEDTECH, S.L.
Tipo de prueba: INV. CLINICA PRODUCTO SANITARIO COM.
Tiempo de ejecución: 05/11/2020 - 30/06/2021
IP: FRANCISCA SONIA MOLINA GARCIA
