MP16-Inmunomodulación Intestinal
Medicina de Precisión / IBS-MP16
Desarrollo de estrategias para el diagnóstico, prevención y tratamiento de enfermedades digestivas y metabólicas. El tratamiento dirigido a la modulación del sistema inmune intestinal con productos naturales, fármacos de síntesis o estrategias de carácter nutricional. Forman parte del grupo de investigación personal procedente del departamento de Farmacología (CIBER-ehd; Universidad de Granada), del departamento de Pediatría (Universidad de Granada), del departamento de Nutrición y Bromatología (Universidad de Granada) y de la UGC de Endoscopia Digestiva (Hospital Universitario Virgen de las Nieves, Granada)
Líneas de investigación
- Caracterización de alimentos funcionales con propiedades prebióticas
- Nuevas estrategias en el tratamiento afecciones intestinales y metabólicas: enfermedad inflamatoria intestinal, síndrome intestino irritable, cáncer colorrectal y síndrome metabólico
Redes de investigación
- CIBEREHD
Palabras clave
Farmacología, Nutrición, Endoscopia digestiva.
MARIA JESUS RODRIGUEZ SOJO
MARIA JOSE RODRIGUEZ SANCHEZ
BENITO MIRON POZO
JORGE RAMOS SANFIEL
MARIA ELENA RODRIGUEZ CABEZAS
ANTONIO JESUS RUIZ MALAGON
MIGUEL RUIZ-CABELLO JIMENEZ
FERMIN SANCHEZ DE MEDINA LOPEZ-HUERTAS
MARIA PILAR UTRILLA NAVARRO
MARGARITA MARTINEZ ZALDIVAR
JOSE ALBERTO MOLINA TIJERAS
FLOR NOGUERAS LOPEZ
MANUEL OLALLA HERRERA
EDUARDO REDONDO CEREZO
ALBA RODRIGUEZ NOGALES
LAURA HIDALGO GARCIA
FRANCISCO JOSE HUERTAS PEÑA
MARIA ANGELES LOPEZ GARRIDO
MARIA DEL MAR MARTIN RODRIGUEZ
BENITA MARTIN CASTAÑO
JUAN GABRIEL MARTINEZ CARA
OLGA MARTINEZ AUGUSTIN
ANTONIO MARIA CABALLERO MATEOS
PATRICIA DIEZ ECHAVE
JULIO JUAN GALVEZ PERALTA
RAFAEL GIMENEZ MARTINEZ
RAQUEL GONZALEZ PEREZ
Título: Isolation, identification, and characterization of strains with probiotic activity, from faeces of infants fed exclusively with breast milk
Código: PCT/ES2010/000097
Inventores:: GALVEZ PERALTA JULIO JUAN ; GARCIA FERNANDEZ JOSE MANUEL ; GOMEZ GARCIA MARTA ; ORTIZ MELLET CARMEN ; RUBIO CASTILLO ENRIQUE MIGUEL; ZARZUELO ZURITA ANTONIO
Título: NUEVOS CARAMELOS CON ELEVADO CONTENIDO EN OLIGOSACARIDOS PREBIOTICOS, PROCEDIMIENTO DE PREPARACION Y UTILIZACION
Código: P200700675
Changes to the gut microbiota induced by losartan contributes to its antihypertensive effects
BRITISH JOURNAL OF PHARMACOLOGY, 2020;
FI:7,73; D1
Anti-Inflammatory and Chemopreventive Effects ofBryophyllum pinnatum(Lamarck) Leaf Extract in Experimental Colitis Models in Rodents
FRONTIERS IN PHARMACOLOGY, 2020;
FI:4,225; Q1
Circadian Rhythms in Hormone-sensitive Lipase in Human Adipose Tissue: Relationship to Meal Timing and Fasting Duration
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2020;
FI:5,399; Q1
MAP(ASH): A new scoring system for the prediction of intervention and mortality in upper gastrointestinal bleeding
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2020;
FI:3,632; Q2
Advances in the diagnosis of ocular toxoplasmosis: Use of optical coherence tomography
ANALES DE PEDIATRIA, 2020;
FI:1,313; Q3
Enhancement of immune response mediated by oropharyngeal colostrum administration in preterm neonates
PEDIATRIC ALLERGY AND IMMUNOLOGY, 2019;
FI:4,654; D1
The Immunomodulatory Properties of Propyl-Propane Thiosulfonate Contribute to its Intestinal Anti-Inflammatory Effect in Experimental Colitis
MOLECULAR NUTRITION & FOOD RESEARCH, 2019;
FI:4,653; D1
Intestinal epithelial deletion of the glucocorticoid receptor NR3C1 alters expression of inflammatory mediators and barrier function
FASEB JOURNAL, 2019;
FI:5,391; D1
Maternal and Neonatal Hair Cortisol Levels Are Associated with Infant Neurodevelopment at Six Months of Age
JOURNAL OF CLINICAL MEDICINE, 2019;
FI:5,688; D1
Transcriptional Profiling of Dendritic Cells in a Mouse Model of Food-Antigen-Induced Anaphylaxis Reveals the Upregulation of Multiple Immune-Related Pathways
MOLECULAR NUTRITION & FOOD RESEARCH, 2019;
FI:4,653; D1
Choledochoduodenal Fistula Secondary to Ulcer Disease Presenting With Gastrointestinal Bleeding
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 2018;
FI:7,683; D1
Calprotectin protects against experimental colonic inflammation in mice
BRITISH JOURNAL OF PHARMACOLOGY, 2018;
FI:6,81; D1
Immunomodulatory tetracyclines shape the intestinal inflammatory response inducing mucosal healing and resolution
BRITISH JOURNAL OF PHARMACOLOGY, 2018;
FI:6,81; D1
Potential Role of Seaweed Polyphenols in Cardiovascular-Associated Disorders
MARINE DRUGS, 2018;
FI:4,379; D1
Lactobacillus fermentum Improves Tacrolimus-Induced Hypertension by Restoring Vascular Redox State and Improving eNOS Coupling
MOLECULAR NUTRITION & FOOD RESEARCH, 2018;
FI:5,151; D1
Hepatic Hydatid Cysts Causing Biliary Obstruction
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 2017;
FI:7,398; D1
A synbiotic composed of Lactobacillus fermentum CECT5716 and FOS prevents the development of fatty acid liver and glycemic alterations in rats fed a high fructose diet associated with changes in the microbiota
MOLECULAR NUTRITION & FOOD RESEARCH, 2017;
FI:4,323; D1
Differential intestinal anti-inflammatory effects of Lactobacillus fermentum and Lactobacillus salivarius in DSS mouse colitis: impact on microRNAs expression and microbiota composition
MOLECULAR NUTRITION & FOOD RESEARCH, 2017;
FI:4,323; D1
Immunomodulatory properties of Olea europaea leaf extract in intestinal inflammation
MOLECULAR NUTRITION & FOOD RESEARCH, 2017;
FI:4,323; D1
Metformin for Obesity in Prepubertal and Pubertal Children: A Randomized Controlled Trial
PEDIATRICS, 2017;
FI:5,705; D1
Antiinflammatory and immunomodulatory activity of an ethanolic extract from the stem bark of Terminalia catappa L. (Combretaceae): In vitro and in vivo evidences
JOURNAL OF ETHNOPHARMACOLOGY, 2016;
FI:3,055; D1
Germ-free and Antibiotic-treated Mice are Highly Susceptible to Epithelial Injury in DSS Colitis
JOURNAL OF CROHNS & COLITIS, 2016;
FI:6,585; D1
Intestinal anti-inflammatory effects of Passiflora edulis peel in the dextran sodium sulphate model of mouse colitis
JOURNAL OF FUNCTIONAL FOODS, 2016;
FI:3,973; D1
The glucocorticoid budesonide has protective and deleterious effects in experimental colitis in mice
BIOCHEMICAL PHARMACOLOGY, 2016;
FI:5,091; D1
Anti-inflammatory activity of hydroalcoholic extracts of Lavandula dentata L. and Lavandula stoechas L.
JOURNAL OF ETHNOPHARMACOLOGY, 2016;
FI:3,055; D1
Pea (Pisum sativum L.) seed albumin extracts show anti-inflammatory effect in the DSS model of mouse colitis
MOLECULAR NUTRITION & FOOD RESEARCH, 2015;
FI:4,603; D1
The small intestinal mucosa acts as a rutin reservoir to extend flavonoid anti-inflammatory activity in experimental ileitis and colitis
JOURNAL OF FUNCTIONAL FOODS, 2015;
FI:3,574; D1
Antihypertensive effects of probiotics Lactobacillus strains in spontaneously hypertensive rats
MOLECULAR NUTRITION & FOOD RESEARCH, 2015;
FI:4,603; D1
A new therapeutic association to manage relapsing experimental colitis: Doxycycline plus Saccharomyces boulardii
PHARMACOLOGICAL RESEARCH, 2015;
FI:4,408; Q1
Diagnostic screening for subclinical celiac disease using a rapid test in children aged 2-4
PEDIATRIC RESEARCH, 2015;
FI:2,314; Q1
PI20/01447 – New insights in mechanism underlying immediate reactions induced by amoxicillin and clavulanic acid for improving diagnosis
Financiador: INSTITUTO DE SALUD CARLOS III
Número de expediente: PI20/01447
Tiempo de ejecución: 01/01/2021 - 31/12/2023
IP: ALBA RODRIGUEZ NOGALES
INFLAMACION, FUNCION DE BARRERA INTESTINAL Y SINDROME METABOLICO. MODULACION POR ALIMENTOS FUNCIONALES
Financiador: MINISTERIO DE ECONOMIA Y COMPETITIVIDAD
Número de expediente: AGL2014-58883-R
Tiempo de ejecución: 01/01/2015 - 31/12/2017
IP: OLGA MARTINEZ AUGUSTIN
REGULACION DE LA FUNCION DE BARRERA INTESTINAL POR CORTICOIDES, CALPROTECTINA, Y EL INTERCAMBIADOR SODIO-HIDROGENO NHE3
Financiador: MINISTERIO DE ECONOMIA Y COMPETITIVIDAD
Número de expediente: BFU2014-57736-P
Tiempo de ejecución: 01/01/2015 - 31/12/2017
IP: FERMIN SANCHEZ DE MEDINA LOPEZ-HUERTAS
Potencial Terapéutico de Exosomas Derivados de Células Estromales Mesenquimales en Inflamación Intestinal
Financiador: CONSEJERÍA DE SALUD
Número de expediente: PI-0206-2016
Tiempo de ejecución: 01/01/2017 - 31/12/2019
IP: MARIA ELENA RODRIGUEZ CABEZAS
ALBINO – Effect of ALlopurinol in addition to hypothermia for hypoxic-ischemic Brain Injury on Neurocognitive Outcme – a blinded randomized placebo-controlled multicenter trial
Financiador: COMISION EUROPEA
Número de expediente: EECC-667224
Tiempo de ejecución: 07/12/2017 - 07/12/2022
IP: JOSE ANTONIO HURTADO SUAZO
A Phase 2b Randomized, Double-Blind, Placebo-controlled Study to Evaluate the Safety and Efficacy of MEDI8897, a Monoclonal Antibody With an Extended Half-life Against Respiratory Syncytial Virus, in Healthy Preterm Infants
Financiador: MEDIMMUNE LLC
Tipo de prueba: ENSAYO CLINICO COMERCIAL
Tiempo de ejecución: 09/06/2017 - 31/12/2019
IP: JOSE ANTONIO HURTADO SUAZO
