E07-Investigación en Salud Ambiental e Infancia

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Grupo integrado en el CIBER de Epidemiología y Salud Pública (CIBERESP) dedicado a la investigación en salud ambiental, nutricional y laboral (biomonitorización de contaminantes químicos ambientales, exposición a tóxicos y efectos sobre la salud), epidemiología molecular y genética, así como aspectos relacionados con la promoción y protección de la salud infantil.

Líneas de investigación

El origen temprano de la salud y la enfermedad (Developmental Origins of Health and Disease (DOHaD)
Epi/genética ambiental, salud reproductiva y desarrollo infantil
Exposición humana a contaminantes químicos ambientales, análisis de predictores de la exposición y efectos en salud
Promoción y protección de la salud infantil

Redes de investigación

CIBERESP Centro de Investigación Biomédica en red Epidemiología y Salud Pública (CB06/02/1021)

Palabras clave

Contaminantes químicos persistentes y no persistentes, epidemiología ambiental y molecular, disruptores endocrinos, salud reproductiva, salud infantil, promoción de la salud, interacción gen-ambiente

HELENA GARCIA CORTES

ORCID

BEATRIZ GONZALEZ ALZAGA

ORCID

ANTONIO FRANCISCO HERNANDEZ JEREZ

MARINA LACASAÑA NAVARRO

INMACULADA LOPEZ FLORES

DESIREE ROMERO MOLINA

Lozano-Paniagua, D; Parrón, T; Alarcón, R; Requena, M; Lacasaña, M; Hernández, AF

A Th2-type immune response and low-grade systemic inflammatory reaction as potential immunotoxic effects in intensive agriculture farmers exposed to pesticides

SCIENCE OF THE TOTAL ENVIRONMENT, 2024;

FI:8,2; D1

Navajas-Porras, B; Delgado-Osorio, A; Hinojosa-Nogueira, D; Pastoriza, S; Almécija-Rodríguez, MD; Rufián-Henares, JA; Fernandez-Bayo, JD

Improved nutritional and antioxidant properties of black soldier fly larvae reared on spent coffee grounds and blood meal by-products

FOOD RESEARCH INTERNATIONAL, 2024;

FI:7; D1

García-Conde, U; Navarro-Moreno, M; Navajas-Porras, B; Hinojosa-Nogueira, D; Delgado-Osorio, A; Pastoriza, S; Moriki, D; Douros, K; Navarro-Alarcón, M; Rufián-Henares, JA

Do cooking techniques influence copper bioaccesibility in foods after in vitro digestion/fermentation in adults and children?

FOOD RESEARCH INTERNATIONAL, 2024;

FI:7; D1

Hinojosa-Nogueira, D; Russo, MD; Navajas-Porras, B; Delgado-Osorio, A; Pérez-Burillo, S; La Grutta, S; Cilluffo, G; Malizia, V; de la Cueva, SP; Lauria, F; Rufián-Henares, JA

Associations between the prevalence of asthma and dietary exposure to food contaminants in children: CHASER study

WORLD JOURNAL OF PEDIATRICS, 2024;

FI:3,6; D1

García-Burgos, A; Paraggio, P; Romero-Molina, D; Rico-Castro, N

Inference with Non-Homogeneous Lognormal Diffusion Processes Conditioned on Nearest Neighbor

MATHEMATICS, 2024;

FI:2,3; D1

García-Conde, U; Navarro-Alarcón, M; Navajas-Porras, B; Hinojosa-Nogueira, D; Delgado-Osorio, A; Pérez-Burillo, S; Pastoriza, S; Navarro-Moreno, M; Rufián-Henares, JA

Total Zn of foods and bioaccesible fractions in the small and large intestine after in vitro digestion and fermentation with fecal material of healthy adults and children: Influence of culinary techniques

FOOD RESEARCH INTERNATIONAL, 2023;

FI:8,1; D1

Lozano-Paniagua, D; Parrón, T; Alarcón, R; Requena, M; Lacasaña, M; Hernández, AF

Renal tubular dysfunction in greenhouse farmers exposed to pesticides unveiled by a panel of molecular biomarkers of kidney injury

ENVIRONMENTAL RESEARCH, 2023;

FI:8,3; Q1

Bermúdez-Tamayo, C; Mochón, LG; Azarola, AR; Lacasaña, M

Climate change and vector-borne diseases. From knowledge to action

GACETA SANITARIA, 2023;

FI:1,9; Q4

Cofiño, R; Prieto, M; Hernán-García, M

Community or barbarism. Community orientation of primary health care at three levels

GACETA SANITARIA, 2023;

FI:1,9; Q4

Cardo-Miota, A; Valls-Pérez, B; Lineros-González, C; Hernán-García, M

Community health. Innovating in the training of family and community medicine residents

GACETA SANITARIA, 2023;

FI:1,9; Q4

Karaulov, AV; Smolyagin, AI; Mikhailova, IV; Stadnikov, AA; Ermolina, EV; Filippova, YV; Kuzmicheva, NA; Vlata, Z; Djordjevic, AB; Tsitsimpikou, C; Hartung, T; Hernandez, AF; Tsatsakis, A

Assessment of the combined effects of chromium and benzene on the rat neuroendocrine and immune systems

ENVIRONMENTAL RESEARCH, 2022;

FI:8,431; D1

Garzarella, EU; Navajas-Porras, B; Perez-Burillo, S; Ullah, H; Esposito, C; Santarcangelo, C; Hinojosa-Nogueira, D; Pastoriza, S; Zaccaria, V; Xiao, JB; Rufian-Henares, JA; Daglia, M

Evaluating the effects of a standardized polyphenol mixture extracted from poplar-type propolis on healthy and diseased human gut microbiota

BIOMEDICINE & PHARMACOTHERAPY, 2022;

FI:7,419; D1

Martin-Way, D; Puche-Sanz, I; Cozar, JM; Zafra-Gomez, A; Gomez-Regalado, MDC; Morales-Alvarez, CM; Hernandez, AF; Martinez-Gonzalez, LJ; Alvarez-Cubero, MJ

Genetic variants of antioxidant enzymes and environmental exposures as molecular biomarkers associated with the risk and aggressiveness of bladder cancer

SCIENCE OF THE TOTAL ENVIRONMENT, 2022;

FI:10,753; D1

Navajas-Porras, B; Perez-Burillo, S; Hinojosa-Nogueira, D; Pastoriza, S; Rufian-Henares, JA

Relationship of Thermal Treatment and Antioxidant Capacity in Cooked Foods

ANTIOXIDANTS, 2022;

FI:7,675; D1

Gonzalez-Alzaga, B; Hernandez, AF; Pack, LK; Iavicoli, I; Tolonen, H; Santonen, T; Vinceti, M; Filippini, T; Moshammer, H; Probst-Hensch, N; Kolossa-Gehring, M; Lacasana, M

The questionnaire design process in the European Human Biomonitoring Initiative (HBM4EU)

ENVIRONMENT INTERNATIONAL, 2022;

FI:13,352; D1

Lopez-Maldonado, A; Pastoriza, S; Rufian-Henares, JA

Assessing the antioxidant and metabolic effect of an alpha-lipoic acid and acetyl-L-carnitine nutraceutical

CURRENT RESEARCH IN FOOD SCIENCE, 2021;

Blasco, T; Perez-Burillo, S; Balzerani, F; Hinojosa-Nogueira, D; Lerma-Aguilera, A; Pastoriza, S; Cendoya, X; Rubio, A; Gosalbes, MJ; Jimenez-Hernandez, N; Francino, M; Apaolaza, I; Rufian-Henares, JA; Planes, FJ

An extended reconstruction of human gut microbiota metabolism of dietary compounds

NATURE COMMUNICATIONS, 2021;

FI:14,919; D1

Perez-Burillo, S; Molino, S; Navajas-Porras, B; Valverde-Moya, AJ; Hinojosa-Nogueira, D; Lopez-Maldonado, A; Pastoriza, S; Rufian-Henares, JA

An in vitro batch fermentation protocol for studying the contribution of food to gut microbiota composition and functionality

NATURE PROTOCOLS, 2021;

FI:13,491; D1

More, S; Bampidis, V; Benford, D; Bragard, C; Halldorsson, T; Hernandez-Jerez, A; Bennekou, SH; Koutsoumanis, K; Machera, K; Naegeli, H; Nielsen, SS; Schlatter, J; Schrenk, D; Silano, V; Turck, D; Younes, M; Arnold, G; Dorne, JL; Maggiore, A; Pagani, S; S

A systems-based approach to the environmental risk assessment of multiple stressors in honey bees

EFSA JOURNAL, 2021;

FI:3,336; Q2

Hinojosa-Nogueira, D; Perez-Burillo, S; Garcia-Rincon, I; Rufian-Henares, JA; Pastoriza, S

A useful and simple tool to evaluate and compare the intake of total dietary polyphenols in different populations

PUBLIC HEALTH NUTRITION, 2021;

FI:4,022; Q2

Hernandez, AF; Docea, AO; Goumenou, M; Sarigiannis, D; Aschner, M; Tsatsakis, A

Application of novel technologies and mechanistic data for risk assessment under the real-life risk simulation (RLRS) approach

FOOD AND CHEMICAL TOXICOLOGY, 2020;

FI:4,679; D1

Perez-Burillo, S; Rajakaruna, S; Pastoriza, S; Paliy, O; Rufian-Henares, JA

Bioactivity of food melanoidins is mediated by gut microbiota

FOOD CHEMISTRY, 2020;

FI:6,306; D1

Henriquez-Hernandez, LA; Romero, D; Gonzalez-Antuna, A; Gonzalez-Alzaga, B; Zumbado, M; Boada, LD; Hernandez, AF; Lopez-Flores, I; Luzardo, OP; Lacasana, M

Biomonitoring of 45 inorganic elements measured in plasma from Spanish subjects: A cross-sectional study in Andalusian population

SCIENCE OF THE TOTAL ENVIRONMENT, 2020;

FI:6,551; D1

Hinojosa-Nogueira, D; Perez-Burillo, S; Rufian-Henares, JA; de la Cueva, SP

Characterization of rums sold in Spain through their absorption spectra, furans, phenolic compounds and total antioxidant capacity

FOOD CHEMISTRY, 2020;

FI:6,306; D1

Tsatsakis, A; Petrakis, D; Nikolouzakis, TK; Docea, AO; Calina, D; Vinceti, M; Goumenou, M; Kostoff, RN; Mamoulakis, C; Aschner, M; Hernandez, AF

COVID-19, an opportunity to reevaluate the correlation between long-term effects of anthropogenic pollutants on viral epidemic/pandemic events and prevalence

FOOD AND CHEMICAL TOXICOLOGY, 2020;

FI:4,679; D1

Caparros-Gonzalez, RA; Gimenez-Asensio, MJ; Gonzalez-Alzaga, B; Aguilar-Garduno, C; Lorca-Marin, JA; Alguacil, J; Gomez-Becerra, I; Gomez-Ariza, JL; Garcia-Barrera, T; Hernandez, AF; Lopez-Flores, I; Rohlman, DS; Romero-Molina, D; Ruiz-Perez, I; Lacasana, M

Childhood chromium exposure and neuropsychological development in children living in two polluted areas in southern Spain

ENVIRONMENTAL POLLUTION, 2019;

FI:5,714; D1

Cervera-Mata, A; Navarro-Alarcon, M; Delgado, G; Pastoriza, S; Montilla-Gomez, J; Llopis, J; Sanchez-Gonzalez, C; Rufian-Henares, JA

Spent coffee grounds improve the nutritional value in elements of lettuce (Lactuca sativa L.) and are an ecological alternative to inorganic fertilizers

FOOD CHEMISTRY, 2019;

FI:5,399; D1

Hernandez, AF; Lozano-Paniagua, D; Gonzalez-Alzaga, B; Kavvalakis, MP; Tzatzarakis, MN; Lopez-Flores, I; Aguilar-Garduno, C; Caparros-Gonzalez, RA; Tsatsakis, AM; Lacasana, M

Biomonitoring of common organophosphate metabolites in hair and urine of children from an agricultural community

ENVIRONMENT INTERNATIONAL, 2019;

FI:7,943; D1

Perez-Burillo, S; Mehta, T; Esteban-Munoz, A; Pastoriza, S; Paliy, O; Rufian-Henares, JA

Effect of in vitro digestion-fermentation on green and roasted coffee bioactivity: The role of the gut microbiota

FOOD CHEMISTRY, 2019;

FI:5,399; D1

Perez-Burillo, S; Pastoriza, S; Fernandez-Arteaga, A; Luzon, G; Jimenez-Hernandez, N; D'Auria, G; Francino, MP; Rufian-Henares, JA

Spent Coffee Grounds Extract, Rich in Mannooligosaccharides, Promotes a Healthier Gut Microbial Community in a Dose-Dependent Manner

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2019;

FI:3,571; D1

Perez-Burillo, S; Rufian-Henares, JA; Pastoriza, S

Towards an improved global antioxidant response method (GAR plus ): Physiological-resembling in vitro digestion-fermentation method

FOOD CHEMISTRY, 2018;

FI:4,946; D1

Perez-Burillo, S; Rufian-Henares, JA; Pastoriza, S

Towards an improved Global Antioxidant Response method (GAR plus ): Physiological-resembling in vitro antioxidant capacity methods

FOOD CHEMISTRY, 2018;

FI:4,946; D1

Perez-Burillo, S; Gimenez, R; Rufian-Henares, JA; Pastoriza, S

Effect of brewing time and temperature on antioxidant capacity and phenols of white tea: Relationship with sensory properties

FOOD CHEMISTRY, 2018;

FI:4,946; D1

Perez-Burillo, S; Pastoriza, S; Jimenez-Hernandez, N; D'Auria, G; Francino, MP; Rufian-Henares, JA

Effect of Food Thermal Processing on the Composition of the Gut Microbiota

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2018;

FI:3,412; D1

Gonzalez-Alzaga, B; Lacasana, M; Hernandez, AF; Arrebola, JP; Lopez-Flores, I; Artacho-Cordon, F; Bonde, JP; Olea, N; Aguilar-Garduno, C

Serum concentrations of organochlorine compounds and predictors of exposure in children living in agricultural communities from South-Eastern Spain

ENVIRONMENTAL POLLUTION, 2018;

FI:4,358; Q1

Hernandez, AF; Gil, F; Lacasana, M

Toxicological interactions of pesticide mixtures: an update

ARCHIVES OF TOXICOLOGY, 2017;

FI:5,901; D1

Hinojosa-Nogueira, D; Muros, J; Rufian-Henares, JA; Pastoriza, S

New Method To Estimate Total Polyphenol Excretion: Comparison of Fast Blue BB versus Folin-Ciocalteu Performance in Urine

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2017;

FI:3,154; D1

de la Cueva, SP; Alvarez, J; Vegvari, A; Montilla-Gomez, J; Cruz-Lopez, O; Delgado-Andrade, C; Rufian-Henares, JA

Relationship between HMF intake and SMF formation in vivo: An animal and human study

MOLECULAR NUTRITION & FOOD RESEARCH, 2017;

FI:4,323; D1

Mustieles, V; Fernandez, MF; Martin-Olmedo, P; Gonzalez-Alzaga, B; Fontalba-Navas, A; Hauser, R; Olea, N; Arrebola, JP

Human adipose tissue levels of persistent organic pollutants and metabolic syndrome components: Combining a cross-sectional with a 10-year longitudinal study using a multi-pollutant approach

ENVIRONMENT INTERNATIONAL, 2017;

FI:7,088; D1

Panzella, L; Perez-Burillo, S; Pastoriza, S; Martin, MA; Cerruti, P; Goya, L; Ramos, S; Rufian-Henares, JA; Napolitano, A; d'Ischia, M

High Antioxidant Action and Prebiotic Activity of Hydrolyzed Spent Coffee Grounds (HSCG) in a Simulated Digestion-Fermentation Model: Toward the Development of a Novel Food Supplement

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2017;

FI:3,154; D1

Hernandez, AF; Gonzalez-Alzaga, B; Lopez-Flores, I; Lacasana, M

Systematic reviews on neurodevelopmental and neurodegenerative disorders linked to pesticide exposure: Methodological features and impact on risk assessment

ENVIRONMENT INTERNATIONAL, 2016;

FI:5,929; D1

Rodriguez-Barranco, M; Gil, F; Hernandez, AF; Alguacil, J; Lorca, A; Mendoza, R; Gomez, I; Molina-Villalba, I; Gonzalez-Alzaga, B; Aguilar-Garduno, C; Rohlman, DS; Lacasana, M

Postnatal arsenic exposure and attention impairment in school children

CORTEX, 2016;

FI:4,314; D1

Jimenez-Zamora, A; Delgado-Andrade, C; Rufian-Henares, JA

Antioxidant capacity, total phenols and color profile during the storage of selected plants used for infusion

FOOD CHEMISTRY, 2016;

FI:4,052; D1

Arques, MC; Pastoriza, S; Delgado-Andrade, C; Clemente, A; Rufian-Henares, JA

Relationship between Glycation and Polyphenol Content and the Bioactivity of Selected Commercial Soy Milks

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2016;

FI:2,857; D1

Blanco-Munoz, J; Lacasana, M; Lopez-Flores, I; Rodriguez-Barranco, M; Gonzalez-Alzaga, B; Bassol, S; Cebrian, ME; Lopez-Carrillo, L; Aguilar-Garduno, C

Association between organochlorine pesticide exposure and thyroid hormones in floriculture workers

ENVIRONMENTAL RESEARCH, 2016;

FI:3,088; Q1

Gonzalez-Alzaga, B; Hernandez, AF; Rodriguez-Barranco, M; Gomez, I; Aguilar-Garduno, C; Lopez-Flores, I; Parron, T; Lacasana, M

Pre- and postnatal exposures to pesticides and neurodevelopmental effects in children living in agricultural communities from South-Eastern Spain

ENVIRONMENT INTERNATIONAL, 2015;

FI:5,559; D1

Rojas-Garcia, A; Ruiz-Perez, I; Rodriguez-Barranco, M; Goncalves Bradley, DC; Pastor-Moreno, G; Ricci-Cabello, I

Healthcare interventions for depression in low socioeconomic status populations: A systematic review and meta-analysis

CLINICAL PSYCHOLOGY REVIEW, 2015;

FI:6,932; D1

Pastoriza, S; Rufian-Henares, JA; Delgado-Andrade, C

Effects of long-term consumption of standard diets including glucose-lysine model glycated compounds on the antioxidant status of adult rats

FOOD CHEMISTRY, 2015;

FI:3,391; D1

Gomez-Martin, A; Hernandez, AF; Martinez-Gonzalez, LJ; Gonzalez-Alzaga, B; Rodriguez-Barranco, M; Lopez-Flores, I; Aguilar-Garduno, C; Lacasana, M

Polymorphisms of pesticide-metabolizing genes in children living in intensive farming communities

CHEMOSPHERE, 2015;

FI:3,34; Q1

Muros, JJ; Zabala, M; Oliveras-Lopez, MJ; Bouzas, PR; Knox, E; Rufian-Henares, JA; de la Serrana, HLG

Effect of Physical Activity, Nutritional Education, and Consumption of Extra Virgin Olive Oil on Lipid, Physiological, and Anthropometric Profiles in a Pediatric Population

JOURNAL OF PHYSICAL ACTIVITY & HEALTH, 2015;

FI:2,09; Q1

Efecto de la exposición pre y postnatal a glifosato y AMPA en el desarrollo neuropsicológico infantil: efecto mediador de biomarcadores de daño neurológico y perfil tiroideo.

Financiador: INSTITUTO DE SALUD CARLOS III - FEDER

Número de expediente: PI23/01389

Tiempo de ejecución: 01/01/2024 - 31/12/2026

IP: BEATRIZ GONZALEZ ALZAGA

Efecto de la exposición prenatal a mezclas de compuestos organofosforados sobre la expresión y metilación de genes de placenta implicados en el crecimiento fetal y neurodesarrollo infantil.

Financiador: FUNDACION PUBLICA ANDALUZA PROGRESO Y SALUD

Número de expediente: FPS-0199-2021

Tiempo de ejecución: 23/03/2022 - 23/03/2025

IP: MARINA LACASAÑA NAVARRO

PARC – Partnership for the Assessment of Risks from Chemicals

Financiador: COMISION EUROPEA

Número de expediente: 101057014

Tiempo de ejecución: 01/05/2022 - 01/06/2029

IP: MARINA LACASAÑA NAVARRO

PI-0405-2014 – Efecto de la Ingesta Materna de Nutrientes Donadores de Grupos Metilo Sobre la Metilación de Adn de Placenta y el Crecimiento Fetal

Financiador: FUNDACION PUBLICA ANDALUZA PROGRESO Y SALUD

Número de expediente: PI-0405-2014

Tiempo de ejecución: 01/08/2015 - 31/07/2017

IP: INMACULADA LOPEZ FLORES

Interacción Entre la Exposición A Plaguicidas Organofosforados y el Estrés Psicologico de la Madre Durante el Embarazo Sobre Los Niveles de Cortisol, Crecimiento Fetal y Neurodesarrollo Infantil.

Financiador: CONSEJERÍA DE SALUD

Número de expediente: PS-0205-2016

Tiempo de ejecución: 01/01/2017 - 31/12/2018

IP: MARINA LACASAÑA NAVARRO

Perfil metabolómico materno del crecimiento fetal y su asociación con la exposición a plaguicidas organofosforados

Financiador: INSTITUTO DE SALUD CARLOS III - FEDER

Número de expediente: PI17/01650

Tiempo de ejecución: 01/01/2018 - 31/12/2020

IP: INMACULADA LOPEZ FLORES

Exposición prenatal y postnatal a retardantes de llama organofosforados y neurodesarrollo a los 12 y 24 meses de edad.

Financiador: INSTITUTO DE SALUD CARLOS III - FEDER

Número de expediente: PI17/00638

Tiempo de ejecución: 01/01/2018 - 31/12/2020

IP: MARINA LACASAÑA NAVARRO

European Human Biomonitoring Iniciative (EHBMI)

Financiador: COMISION EUROPEA

Número de expediente: 733032

Tiempo de ejecución: 01/01/2017 - 31/12/2021

IP: MARINA LACASAÑA NAVARRO

Estudio prospectivo de los efectos de la exposición prenatal a mezclas de metales sobre el neurodesarrollo infantil a las edades de 1, 2 y 4 años

Financiador: CONSEJERÍA DE SALUD Y FAMILIAS

Número de expediente: PI-0243-2019

Tiempo de ejecución: 01/01/2020 - 31/12/2022

IP: BEATRIZ GONZALEZ ALZAGA

STANCE4HEALTH – Smart Technologies for personAlised Nutrition and Consumer Engagement

Financiador: COMISION EUROPEA

Número de expediente: 816303

Tiempo de ejecución: 01/10/2018 - 30/09/2022