Ae21-Epigenética en Envejecimiento y Cáncer

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Estudiamos el papel de la heterogeneidad epigenética en la biología de las células madre y cáncer.

Líneas de investigación

Disección de las bases moleculares de la memoria epigenética.
Análisis de las rutas epigenéticas asociadas al envejecimiento.
Diseño de intervenciones terapéuticas con fármacos que ralenticen o reviertan el envejecimiento.
Disección de las rutas epigenéticas que regulan la diseminación metastásica.
Diseño de intervenciones terapéuticas con drogas epigenéticas en cáncer.

Palabras clave

cromatina, cáncer, ritmo circadiano, genómica, epigenética, transcriptómica, célula madre, biopsia liquida, diagnóstico prenatal

ISABEL MARIA GARCIA CABRERA

SERGIO SERRANO CORRAL

ADRIAN CASTILLO LINDE

JIAJUN XIE

ANDREA SERRANO PRADOS

IVAN FERNANDEZ RENGEL

MENCIA ESPINOSA MARTINEZ

MARIA ALCAZAR FABRA

ANTONIO SANCHEZ POZO

EFRES BELMONTE RECHE

ORCID

LOURDES LOPEZ ONIEVA

CRISTINA CONDE LOPEZ

ORCID

AMADOR GALLARDO DE LOS REYES

HELENA GOMEZ ASENJO

ORCID

DAVID LANDEIRA FRIAS

XAVIER FRANCISCO LANDIVAR VARAS

ALDARA MOLINA SANCHEZ

MARIA JOSE MOYANO RODRIGUEZ

ORCID

Asenjo, HG; Alcazar-Fabra, M; Espinosa-Martínez, M; Lopez-Onieva, L; Gallardo, A; Dimitrova, E; Feldmann, A; Pachano, T; Martorell-Marugán, J; Carmona-Sáez, P; Sanchez-Pozo, A; Rada-Iglesias, A; Klose, RJ; Landeira, D

Changes in PRC1 activity during interphase modulate lineage transition in pluripotent cells

NATURE COMMUNICATIONS, 2023;

FI:16,6; D1

Domingo-Reinés, J; Montes, R; Garcia-Moreno, A; Gallardo, A; Sanchez-Manas, JM; Ellson, I; Lamolda, M; Calabro, C; López-Escamez, JA; Catalina, P; Carmona-Sáez, P; Real, PJ; Landeira, D; Ramos-Mejia, V

The pediatric leukemia oncoprotein NUP98-KDM5A induces genomic instability that may facilitate malignant transformation

CELL DEATH & DISEASE, 2023;

FI:9; Q1

Gallardo, A; Molina, A; Asenjo, HG; Lopez-Onieva, L; Martorell-Marugan, J; Espinosa-Martinez, M; Grinan-Lison, C; Alvarez-Perez, JC; Cara, FE; Navarro-Marchal, SA; Carmona-Saez, P; Medina, PP; Marchal, JA; Granados-Principal, S; Sanchez-Pozo, A; Landeira, D

EZH2 endorses cell plasticity to non-small cell lung cancer cells facilitating mesenchymal to epithelial transition and tumour colonization.

ONCOGENE, 2022;

FI:8,756; D1

Cebrian, R; Belmonte-Reche, E; Pirota, V; de Jong, A; Morales, JC; Freccero, M; Doria, F; Kuipers, OP

G-Quadruplex DNA as a Target in Pathogenic Bacteria: Efficacy of an Extended Naphthalene Diimide Ligand and Its Mode of Action

JOURNAL OF MEDICINAL CHEMISTRY, 2022;

FI:8,039; D1

Belmonte-Reche, E; Benassi, A; Penalver, P; Cucchiarini, A; Guedin, A; Mergny, JL; Rosu, F; Gabelica, V; Freccero, M; Doria, F; Morales, JC

Thiosugar naphthalene diimide conjugates: G-quadruplex ligands with antiparasitic and anticancer activity

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022;

FI:7,088; D1

Cerqueira, M; Belmonte-Reche, E; Gallo, J; Baltazar, F; Banobre-Lopez, M

Magnetic Solid Nanoparticles and Their Counterparts: Recent Advances towards Cancer Theranostics

PHARMACEUTICS, 2022;

FI:6,525; Q1

Goncalves, RCR; Belmonte-Reche, E; Pina, J; da Silva, MC; Pinto, SCS; Gallo, J; Costa, SPG; Raposo, MMM

Bioimaging of Lysosomes with a BODIPY pH-Dependent Fluorescent Probe

MOLECULES, 2022;

FI:4,927; Q2

Pachano, T; Sanchez-Gaya, V; Ealo, T; Mariner-Fauli, M; Bleckwehl, T; Asenjo, HG; Respuela, P; Cruz-Molina, S; Munoz-San Martin, M; Haro, E; van IJcken, WFJ; Landeira, D; Rada-Iglesias, A

Orphan CpG islands amplify poised enhancer regulatory activity and determine target gene responsiveness

NATURE GENETICS, 2021;

FI:38,33; D1

Cortijo-Gutierrez, M; Sanchez-Hernandez, S; Tristan-Manzano, M; Maldonado-Perez, N; Lopez-Onieva, L; Real, PJ; Herrera, C; Marchal, JA; Martin, F; Benabdellah, K

Improved Functionality of Integration-Deficient Lentiviral Vectors (IDLVs) by the Inclusion of IS2 Protein Docks..

PHARMACEUTICS, 2021;

FI:6,321; Q1

Serrano-Garrido, O; Peris-Torres, C; Redondo-Garcia, S; Asenjo, HG; Plaza-Calonge, MD; Fernandez-Luna, JL; Rodriguez-Manzaneque, JC

ADAMTS1 Supports Endothelial Plasticity of Glioblastoma Cells with Relevance for Glioma Progression

BIOMOLECULES, 2021;

FI:4,879; Q2

Asenjo, HG; Gallardo, A; Lopez-Onieva, L; Tejada, I; Martorell-Marugan, J; Carmona-Saez, P; Landeira, D

Polycomb regulation is coupled to cell cycle transition in pluripotent stem cells

SCIENCE ADVANCES, 2020;

FI:13,117; D1

Garrido-Navas, MC; Garcia-Diaz, A; Molina-Vallejo, MP; Gonzalez-Martinez, C; Lucena, MA; Canas-Garcia, I; Bayarri, C; Delgado, JR; Gonzalez, E; Lorente, JA; Serrano, MJ

The Polemic Diagnostic Role of TP53 Mutations in Liquid Biopsies from Breast, Colon and Lung Cancers

CANCERS, 2020;

FI:6,126; Q1

Gallardo, A; Molina, A; Asenjo, HG; Martorell-Marugan, J; Montes, R; Ramos-Mejia, V; Sanchez-Pozo, A; Carmona-Saez, P; Lopez-Onieva, L; Landeira, D

The molecular clock protein Bmal1 regulates cell differentiation in mouse embryonic stem cells

LIFE SCIENCE ALLIANCE, 2020;

FI:2,622; Q2

Requena, F; Asenjo, HG; Barturen, G; Martorell-Marugan, J; Carmona-Saez, P; Landeira, D

NOMePlot: analysis of DNA methylation and nucleosome occupancy at the single molecule

SCIENTIFIC REPORTS, 2019;

FI:4,011; Q1

Garrido-Navas, C; de Miguel-Perez, D; Exposito-Hernandez, J; Bayarri, C; Amezcua, V; Ortigosa, A; Valdivia, J; Guerrero, R; Puche, JLG; Lorente, JA; Serrano, MJ