A15-Oncología Básica y Clínica

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Ensayos clínicos

Se trata de un grupo multidisciplinar integrado por médicos clínicos, fisioterapeutas, biólogos, químicos y ambientalistas que unen sus esfuerzos en el estudio de las causas ambientales de enfermedades comunes y en el diagnóstico y el tratamiento de las enfermedades tumorales. La participación en el CIBER de Epidemiología y Salud Pública, (Área de Epidemiología Laboral y ambiental), la Red Infancia y Medioambiente (INMA), la red Europea de Biomonitorización de la Exposición ambiental (HBM4EU), la Plataforma de Biobancos y la colaboración en los estudios MCC-Spain, EPIC-España y Proyecto de Excelencia del ibs.Granada (JA Marchal), orientan sobre los objetivos del grupo.

Líneas de investigación

Diagnostico radiológico
Epidemiologia ambiental
Factores de riesgo en enfermedades crónicas
Medicina personalizada
Radiobiología tumoral
Tratamientos oncológicos

Redes de investigación

CIBERESP - Centro de Investigación Biomedica en red Epidemiología y Salud Pública

MIGUEL MARISCAL ARCAS

ORCID

LETICIA HERAS GONZALEZ

ORCID

LYDIA ESPIN MORENO

MARIANA FATIMA FERNANDEZ CABRERA

CARMEN FREIRE WARDEN

LUZ MARIA IRIBARNE DURAN

ORCID

JOSE LUIS MARTIN RODRIGUEZ

ORCID

VICENTE MUSTIELES MIRALLES

ORCID

MARIA ISABEL NUÑEZ TORRES

NICOLAS OLEA SERRANO

FRANCISCO MANUEL PEINADO RODRIGUEZ

ORCID

MARIA POVEDANO JIMENEZ

ORCID

IRIS REINA PEREZ

ORCID

ANDREA RODRIGUEZ CARRILLO

MANUEL ARANDA HARO

FRANCISCO ARTACHO CORDON

DIEGO BECERRA GARCIA

ORCID

Mustieles, V; Perez-Carrascosa, FM; Leon, J; Lange, T; Bonde, JP; Gomez-Pena, C; Artacho-Cordon, F; Barrios-Rodriguez, R; Olmedo-Requena, R; Exposito, J; Jimenez-Moleon, JJ; Arrebola, JP

Adipose Tissue Redox Microenvironment as a Potential Link between Persistent Organic Pollutants and the 16-Year Incidence of Non-hormone-Dependent Cancer..

ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2021;

FI:9,028; D1

Salcedo-Bellido, I; Gomez-Pena, C; Perez-Carrascosa, FM; Vrhovnik, P; Mustieles, V; Echeverria, R; Fiket, Z; Perez-Diaz, C; Barrios-Rodriguez, R; Jimenez-Moleon, JJ; Arrebola, JP

Adipose tissue cadmium concentrations as a potential risk factor for insulin resistance and future type 2 diabetes mellitus in GraMo adult cohort.

SCIENCE OF THE TOTAL ENVIRONMENT, 2021;

FI:7,963; D1

Jeddi, MZ; Virgolino, A; Fantke, P; Hopf, NB; Galea, KS; Remy, S; Viegas, S; Mustieles, V; Fernandez, MF; von Goetz, N; Vicente, JL; Slobodnik, J; Rambaud, L; Denys, S; St-Amand, A; Nakayama, SF; Santonen, T; Barouki, R; Pasanen-Kase, R; Mol, HGJ; Vermeir

A human biomonitoring (HBM) Global Registry Framework: Further advancement of HBM research following the FAIR principles

INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH, 2021;

FI:5,84; Q1

Vela-Soria, F; Garcia-Villanova, J; Mustieles, V; de Haro, T; Antignac, JP; Fernandez, MF

Assessment of perfluoroalkyl substances in placenta by coupling salt assisted liquid-liquid extraction with dispersive liquid-liquid microextraction prior to liquid chromatography-tandem mass spectrometry

TALANTA, 2021;

FI:6,057; Q1

Rodriguez-Carrillo, A; Rosenmai, AK; Mustieles, V; Couderq, S; Fini, JB; Vela-Soria, F; Molina-Molina, JM; Ferrando-Marco, P; Wielsoe, M; Long, MH; Bonefeld-Jorgensen, EC; Olea, N; Vinggaard, AM; Fernandez, MF

Assessment of chemical mixtures using biomarkers of combined biological activity: A screening study in human placentas

REPRODUCTIVE TOXICOLOGY, 2021;

FI:3,143; Q3

Freire, C; Vrhovnik, P; Fiket, Z; Salcedo-Bellido, I; Echeverria, R; Martin-Olmedo, P; Kniewald, G; Fernandez, MF; Arrebola, JP

Adipose tissue concentrations of arsenic, nickel, lead, tin, and titanium in adults from GraMo cohort in Southern Spain: An exploratory study

SCIENCE OF THE TOTAL ENVIRONMENT, 2020;

FI:6,551; D1

Freire, C; Vela-Soria, F; Beneito, A; Lopez-Espinosa, MJ; Ibarluzea, J; Barreto, FB; Casas, M; Vrijheid, M; Fernandez-Tardon, G; Riano-Galan, I; Fernandez, MF

Association of placental concentrations of phenolic endocrine disrupting chemicals with cognitive functioning in preschool children from the Environment and Childhood (INMA) Project

INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH, 2020;

FI:4,801; D1

Olivares-Urbano, MA; Grinan-Lison, C; Zurita, M; del Moral, R; Rios-Arrabal, S; Artacho-Cordon, F; Arrebola, JP; Gonzalez, AR; Leon, J; Marchal, JA; Nunez, MI

Matrix metalloproteases and TIMPs as prognostic biomarkers in breast cancer patients treated with radiotherapy: A pilot study

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2020;

FI:4,658; Q1

Zhang, Y; Mustieles, V; Yland, J; Braun, JM; Williams, PL; Attaman, JA; Ford, JB; Calafat, AM; Hauser, R; Messerlian, C

Association of Parental Preconception Exposure to Phthalates and Phthalate Substitutes With Preterm Birth

JAMA NETWORK OPEN, 2020;

FI:5,032; Q1

Ruiz-Arrebola, S; Tornero-Lopez, AM; Guirado, D; Villalobos, M; Lallena, AM

An on-lattice agent-based Monte Carlo model simulating the growth kinetics of multicellular tumor spheroids

PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS, 2020;

FI:2,485; Q2

Artacho-Cordon, F; Rios-Arrabal, S; Leon, J; Frederiksen, H; Saenz, JM; Martin-Olmedo, P; Fernandez, MF; Olea, N; Arrebola, JP

Adipose tissue concentrations of non-persistent environmental phenols and local redox balance in adults from Southern Spain

ENVIRONMENT INTERNATIONAL, 2019;

FI:7,943; D1

Freire, C; Molina-Molina, JM; Iribarne-Duran, LM; Jimenez-Diaz, I; Vela-Soria, F; Mustieles, V; Arrebola, JP; Fernandez, MF; Artacho-Cordon, F; Olea, N

Concentrations of bisphenol A and parabens in socks for infants and young children in Spain and their hormone-like activities

ENVIRONMENT INTERNATIONAL, 2019;

FI:7,943; D1

Iribarne-Duran, LM; Artacho-Cordon, F; Pena-Caballero, M; Molina-Molina, JM; Jimenez-Diaz, I; Vela-Soria, F; Serrano, L; Hurtado, JA; Fernandez, MF; Freire, C; Olea, N

Presence of Bisphenol A and Parabens in a Neonatal Intensive Care Unit: An Exploratory Study of Potential Sources of Exposure

ENVIRONMENTAL HEALTH PERSPECTIVES, 2019;

FI:7,736; D1

Leon, J; Saenz, JM; Artacho-Cordon, F; Fernandez, MF; Martin-Olmedo, P; Salamanca-Fernandez, E; Gomez-Pena, C; Olea, N; Arrebola, JP

Contribution of sociodemographic, occupational, lifestyle and dietary characteristics to the oxidative stress microenvironment in adipose tissue

ENVIRONMENTAL RESEARCH, 2019;

FI:5,026; D1

Molina-Molina, JM; Jimenez-Diaz, I; Fernandez, MF; Rodriguez-Carrillo, A; Peinado, FM; Mustieles, V; Barouki, R; Piccoli, C; Olea, N; Freire, C

Determination of bisphenol A and bisphenol S concentrations and assessment of estrogen- and anti-androgen-like activities in thermal paper receipts from Brazil, France, and Spain

ENVIRONMENTAL RESEARCH, 2019;

FI:5,026; D1

Artacho-Cordon, F; Fernandez, MF; Frederiksen, H; Iribarne-Duran, LM; Jimenez-Diaz, I; Vela-Soria, F; Andersson, AM; Martin-Olmedo, P; Peinado, FM; Olea, N; Arrebola, JP

Environmental phenols and parabens in adipose tissue from hospitalized adults in Southern Spain

ENVIRONMENT INTERNATIONAL, 2018;

FI:7,297; D1

Messerlian, C; Mustieles, V; Minguez-Alarcon, L; Ford, JB; Calafat, AM; Souter, I; Williams, PL; Hauser, R

Preconception and prenatal urinary concentrations of phenols and birth size of singleton infants born to mothers and fathers from the Environment and Reproductive Health (EARTH) study

ENVIRONMENT INTERNATIONAL, 2018;

FI:7,297; D1

Birks, LE; Struchen, B; Eeftens, M; van Wel, L; Huss, A; Gajsek, P; Kheifets, L; Gallastegi, M; Dalmau-Bueno, A; Estarlich, M; Fernandez, MF; Meder, IK; Ferrero, A; Jimenez-Zabala, A; Torrent, M; Vrijkotte, TGM; Cardis, E; Olsen, J; Valic, B; Vermeulen, R; Vrijheid, M; Roosli, M; Guxens, M

Spatial and temporal variability of personal environmental exposure to radio frequency electromagnetic fields in children in Europe

ENVIRONMENT INTERNATIONAL, 2018;

FI:7,297; D1

Eeftens, M; Struchen, B; Birks, LE; Cardis, E; Estarlich, M; Fernandez, MF; Gajsek, P; Gallastegi, M; Huss, A; Kheifets, L; Meder, IK; Olsen, J; Torrent, M; Trcek, T; Valic, B; Vermeulen, R; Vrijheied, M; van Wel, L; Guxens, M; Roosli, M

Personal exposure to radio-frequency electromagnetic fields in Europe: Is there a generation gap?

ENVIRONMENT INTERNATIONAL, 2018;

FI:7,297; D1

Adoamnei, E; Mendiola, J; Vela-Soria, F; Fernandez, MF; Olea, N; Jorgensen, N; Swan, SH; Torres-Cantero, AM

Urinary bisphenol A concentrations are associated with reproductive parameters in young men

ENVIRONMENTAL RESEARCH, 2018;

FI:4,732; D1

Mustieles, V; Fernandez, MF; Martin-Olmedo, P; Gonzalez-Alzaga, B; Fontalba-Navas, A; Hauser, R; Olea, N; Arrebola, JP

Human adipose tissue levels of persistent organic pollutants and metabolic syndrome components: Combining a cross-sectional with a 10-year longitudinal study using a multi-pollutant approach

ENVIRONMENT INTERNATIONAL, 2017;

FI:7,088; D1

Freire C, Koifman RJ, Koifman S,

Serum levels of organochlorine pesticides in blood donors: A biomonitoring survey in the North of Brazil, 2010-2011

SCIENCE OF THE TOTAL ENVIRONMENT, 2017;

FI:4,9; D1

Giorgis-Allemand, L; Pedersen, M; Bernard, C; Aguilera, I; Beelen, RMJ; Chatzi, L; Cirach, M; Danileviciute, A; Dedele, A; van Eijsden, M; Estarlich, M; Fernandez-Somoano, A; Fernandez, MF; Forastiere, F; Gehring, U; Grazuleviciene, R; Gruzieva, O; Heude, B; Hoek, G; de Hoogh, K; van den Hooven, EH; Haberg, SE; Iniguez, C; Jaddoe, VWV; Korek, M; Lertxundi, A; Lepeule, J; Nafstad, P; Nystad, W; Patelarou, E; Porta, D; Postma, D; Raaschou-Nielsen, O; Rudnai, P; Siroux, V; Sunyer, J; Stephanou, E; Sorensen, M; Eriksen, KT; Tuffnell, D; Varro, MJ; Vrijkotte, TGM; Wijga, A; Wright, J; Nieuwenhuijsen, MJ; Pershagen, G; Brunekreef, B; Kogevinas, M; Slama, R

The Influence of Meteorological Factors and Atmospheric Pollutants on the Risk of Preterm Birth

AMERICAN JOURNAL OF EPIDEMIOLOGY, 2017;

FI:4,825; D1

Messerlian, C; Braun, JM; Minguez-Alarcon, L; Williams, PL; Ford, JB; Mustieles, V; Calafat, AM; Souter, I; Toth, T; Hauser, R

Paternal and maternal urinary phthalate metabolite concentrations and birth weight of singletons conceived by subfertile couples

ENVIRONMENT INTERNATIONAL, 2017;

FI:7,088; D1

Messerlian, C; Mustieles, V; Wylie, BJ; Ford, JB; Keller, M; Ye, XY; Calafat, AM; Williams, PL; Hauser, R

Ultrasound gel as an unrecognized source of exposure to phthalates and phenols among pregnant women undergoing routine scan

INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH, 2017;

FI:4,643; D1

Artacho-Cordon, F; Leon, J; Saenz, JM; Fernandez, MF; Martin-Olmedo, P; Olea, N; Arrebola, JP

Contribution of Persistent Organic Pollutant Exposure to the Adipose Tissue Oxidative Microenvironment in an Adult Cohort: A Multipollutant Approach

ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2016;

FI:5,393; D1

Pastor-Barriuso, R; Fernandez, MF; Castano-Vinyals, G; Whelan, D; Perez-Gomez, B; Llorca, J; Villanueva, CM; Guevara, M; Molina-Molina, JM; Artacho-Cordon, F; Barriuso-Lapresa, L; Tusquets, I; Dierssen-Sotos, T; Aragones, N; Olea, N; Kogevinas, M; Pollan, M

Total Effective Xenoestrogen Burden in Serum Samples and Risk for Breast Cancer in a Population-Based Multicase-Control Study in Spain

ENVIRONMENTAL HEALTH PERSPECTIVES, 2016;

FI:8,443; D1

Birks, L; Casas, M; Garcia, AM; Alexander, J; Barros, H; Bergstrom, A; Bonde, JP; Burdorf, A; Costet, N; Danileviciute, A; Eggesbo, M; Fernandez, MF; Gonzalez-Galarzo, MC; Grazuleviciene, R; Hanke, W; Jaddoe, V; Kogevinas, M; Kull, I; Lertxundi, A; Melaki, V; Andersen, AMN; Olea, N; Polanska, K; Rusconi, F; Santa-Marina, L; Santos, AC; Vrijkotte, T; Zugna, D; Nieuwenhuijsen, M; Cordier, S; Vrijheid, M

Occupational Exposure to Endocrine-Disrupting Chemicals and Birth Weight and Length of Gestation: A European Meta-Analysis

ENVIRONMENTAL HEALTH PERSPECTIVES, 2016;

FI:8,443; D1

Total Effective Xenoestrogen Burden in Serum Samples and Risk for Breast Cancer in a Population-Based Multicase-Control Study in Spain

ENVIRONMENTAL HEALTH PERSPECTIVES, 2016;

FI:8,443; D1

Clemente, DBP; Casas, M; Vilahur, N; Begiristain, H; Bustamante, M; Carsin, AE; Fernandez, MF; Fierens, F; Gyselaers, W; Iniguez, C; Janssen, BG; Lefebvre, W; Llop, S; Olea, N; Pedersen, M; Pieters, N; Santa Marina, L; Souto, A; Tardon, A; Vanpoucke, C; Vrijheid, M; Sunyer, J; Nawrot, TS

Prenatal Ambient Air Pollution, Placental Mitochondrial DNA Content, and Birth Weight in the INMA (Spain) and ENVIRONAGE (Belgium) Birth Cohorts

ENVIRONMENTAL HEALTH PERSPECTIVES, 2016;

FI:8,443; D1

Jimenez-Diaz, I; Vela-Soria, F; Rodriguez-Gomez, R; Zafra-Gomez, A; Ballesteros, O; Navalon, A

Analytical methods for the assessment of endocrine disrupting chemical exposure during human fetal and lactation stages: A review

ANALYTICA CHIMICA ACTA, 2015;

FI:4,513; D1

Arrebola, JP; Fernandez, MF; Martin-Olmedo, P; Bonde, JP; Martin-Rodriguez, JL; Exposito, J; Rubio-Dominguez, A; Olea, N

Historical exposure to persistent organic pollutants and risk of incident hypertension

ENVIRONMENTAL RESEARCH, 2015;

FI:4,373; D1

Fernandez-Rodriguez, M; Arrebola, JP; Artacho-Cordon, F; Amaya, E; Aragones, N; Llorca, J; Perez-Gomez, B; Ardanaz, E; Kogevinas, M; Castano-Vinyals, G; Pollan, M; Olea, N

Levels and predictors of persistent organic pollutants in an adult population from four Spanish regions

SCIENCE OF THE TOTAL ENVIRONMENT, 2015;

FI:4,099; D1

Calvente, I; Fernandez, MF; Perez-Lobato, R; Davila-Arias, C; Ocon, O; Ramos, R; Rios-Arrabal, S; Villalba-Moreno, J; Olea, N; Nunez, MI

Outdoor characterization of radio frequency electromagnetic fields in a Spanish birth cohort

ENVIRONMENTAL RESEARCH, 2015;

FI:4,373; D1

Arrebola, JP; Gonzalez-Jimenez, A; Fornieles-Gonzalez, C; Artacho-Cordon, F; Olea, N; Escobar-Jimenez, F; Fernandez-Soto, ML

Relationship between serum concentrations of persistent organic pollutants and markers of insulin resistance in a cohort of women with a history of gestational diabetes mellitus

ENVIRONMENTAL RESEARCH, 2015;

FI:4,373; D1

Influencia de la exposición a disruptores endocrinos no persistentes en el desarrollo de telarquia simple precoz

Financiador: INSTITUTO DE SALUD CARLOS III

Número de expediente: PI20/01656

Tiempo de ejecución: 01/01/2021 - 31/12/2023

IP: CARMEN FREIRE WARDEN

Desarrollo de Un Procedimiento para la Minimización de la Presencia de Fármacos Antineoplásicos de Origen Hospitalario

Financiador: CONSEJERÍA DE SALUD

Número de expediente: PS-0506-2016

Tiempo de ejecución: 01/01/2017 - 31/12/2019

IP: Desarrollo de Un Procedimiento para la Minimización de la Presencia de Fármacos Antineoplásicos de Origen Hospitalario

Exposición del recién nacido de muy bajo peso a disruptores endocrinos (DEs) en la Unidad de Cuidados Neonatales (UCIN) y evaluación de las consecuencias sobre el desarrollo.

Financiador: INSTITUTO DE SALUD CARLOS III

Número de expediente: PI16/01820

Tiempo de ejecución: 01/01/2017 - 31/12/2019

IP: NICOLAS OLEA SERRANO

ONCONET SUDOE – Réseau Européen de Recherche translationnelle et d’Innovation en oncologie

Financiador: COMISION EUROPEA

Número de expediente: SOE1-P1-F0082-2015

Tiempo de ejecución: 01/07/2016 - 30/06/2019

IP: NICOLAS OLEA SERRANO

Exposure to non-persistent endocrine-disrupting pesticides and reproductive function among adolescent boys: a cross-sectional study in the INMA-Granada cohort

Financiador: INSTITUTO DE SALUD CARLOS III

Número de expediente: CP16/00085-P

Tiempo de ejecución: 01/01/2017 - 31/12/2019

IP: CARMEN FREIRE WARDEN

Carga obesogenica total efectiva: nuevo biomarcador de efecto combinado a obesógenos como factor de riesgo en obesidad

Financiador: INSTITUTO DE SALUD CARLOS III

Número de expediente: PI16/01812

Tiempo de ejecución: 01/01/2017 - 31/12/2019

IP: MARIANA FATIMA FERNANDEZ CABRERA

Contribución de la exposición humana a disruptores endocrinos en la génesis y desarrollo de endometriosis en mujeres en edad fértil.

Financiador: INSTITUTO DE SALUD CARLOS III

Número de expediente: PI17/01743

Tiempo de ejecución: 01/01/2018 - 31/12/2020

IP: FRANCISCO ARTACHO CORDON

Exposición a pesticidas no persistentes, tiempo de la pubertad y susceptibilidad genética en niños y adolecentes: Proyecto INMA-Ado-PubPest

Financiador: INSTITUTO DE SALUD CARLOS III

Número de expediente: PI17/01526

Tiempo de ejecución: 01/01/2018 - 31/12/2020

IP: CARMEN FREIRE WARDEN

Disruptores endocrinos, microbiota y cáncer de mama

Financiador: UNIVERSIDAD DE GRANADA

Número de expediente: B-CTS-254-UGR18

Tiempo de ejecución: 01/01/2020 - 31/12/2021

IP: MARIANA FATIMA FERNANDEZ CABRERA

Evaluación de la Captación Cardiaca INcidental en la Gammagrafía Ósea – Estudio ECCINGO

Financiador: PFIZER, S.L.U.

Tipo de prueba: ESTUDIO POSAUTORIZACION COMERCIAL

Tiempo de ejecución: 07/05/2021 - 07/05/2022

IP: DIEGO BECERRA GARCIA