A03-Moléculas Bioactivas
Oncología / IBS-A03
El grupo se dedica al diseño y síntesis de fármacos antitumorales. El estudio de las relaciones estructura-reactividad nos permite afinar las estructuras de los prototipos, incrementándose la actividad antiproliferativa y disminuyéndose la toxicidad.
Líneas de investigación
- Estructuras homoquirales obtenidas a partir de bencenos disustituidos en posición orto, con actividad antitumoral
- Nuevos compuestos con actividad antitumoral como inhibidores de colina quinasa
Palabras clave
Heterociclos de seis y siete miembros, fármacos antitumorales, purinas
SOLEDAD ROMERO TAMUDO
JOAQUIN MARIA CAMPOS ROSA
MERIEM CHAYAH GHADDAB
MARIA DORA CARRION PEREGRINA
ANA CONEJO GARCIA
OLGA CRUZ LOPEZ
Título: DIANAS BENZOHETEROEPINICOS
Código: P201030415
Inventores: Campos JM; Lopez l; Marchal JA; Boulaiz H; Aránega A; Gallo MA; Espinosa A; Rodríguez-Serrano F; Conejo, Ana
Título: NUEVAS (RS)- 7- O 9- (1,2,3,5- TETRAHIDRO-4,1-BENZOCAZEPIN-3-IL)-7H O9H-PURINAS CON ACTIVIDAD ANTITUMORAL
Código: P200802431
Inventores: ARANEGA JIMENEZ ANTONIA ; CAMPOS ROSA JOAQUIN ; ESPINOSA UBEDA ANTONIO ; GALLO MEZO MIGUEL ANGEL ; GOMEZ VIDAL JOSE ANTONIO ; NUNEZ CARRETERO M DEL CARMEN; MARCHAL CORRALES JUAN ANTONIO; Rodriguez-Serrano F ;
Título: (2,3-DIHIDRO-5H-1,4-BENZODIHETEROEPIN-3-IL)PURINAS CON ACTIVIDAD ANTITUMORAL
Código: P200601538
N-aryltetrahydroisoquinoline derivatives as HA-CD44 interaction inhibitors: Design, synthesis, computational studies, and antitumor effect
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023;
FI:6,7; Q1
Design and Identification of Inhibitors for the Spike-ACE2 Target of SARS-CoV-2
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023;
FI:5,6; Q1
Identification of a Novel Dual Inhibitor of Acetylcholinesterase and Butyrylcholinesterase: In Vitro and In Silico Studies
PHARMACEUTICALS, 2023;
FI:4,6; Q2
Analgesic Activity of 5-Acetamido-2-Hydroxy Benzoic Acid Derivatives and an In-Vivo and In-Silico Analysis of Their Target Interactions
PHARMACEUTICALS, 2023;
FI:4,6; Q2
Galantamine Based Novel Acetylcholinesterase Enzyme Inhibitors: A Molecular Modeling Design Approach
MOLECULES, 2023;
FI:4,6; Q2
Identification of Potential Insect Growth Inhibitor against Aedes aegypti: A Bioinformatics Approach
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2022;
FI:6,208; Q1
Selective Anticancer Therapy Based on a HA-CD44 Interaction Inhibitor Loaded on Polymeric Nanoparticles.
PHARMACEUTICS, 2022;
FI:6,525; Q1
Hierarchical Virtual Screening and Binding Free Energy Prediction of Potential Modulators of Aedes Aegypti Odorant-Binding Protein 1
MOLECULES, 2022;
FI:4,927; Q2
The Role of Celecoxib as a Potential Inhibitor in the Treatment of Inflammatory Diseases-A Review
CURRENT MEDICINAL CHEMISTRY, 2022;
FI:4,74; Q2
NMR spectroscopy study of new imidamide derivatives as nitric oxide synthase inhibitors
MAGNETIC RESONANCE IN CHEMISTRY, 2022;
FI:2,392; Q3
Design, synthesis, HER2 inhibition and anticancer evaluation of new substituted 1,5-dihydro-4,1-benzoxazepines
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2021;
FI:5,051; Q1
Choline Kinase: An Unexpected Journey for a Precision Medicine Strategy in Human Diseases
PHARMACEUTICS, 2021;
FI:6,321; Q1
Development of bozepinib-loaded nanocapsules for nose-to-brain delivery: preclinical evaluation in glioblastoma
NANOMEDICINE, 2021;
FI:5,307; Q1
An Overview of the alpha 4 beta 1 Integrin and the Potential Therapeutic Role of its Antagonists
CURRENT MEDICINAL CHEMISTRY, 2021;
FI:4,53; Q2
Molecular modeling approaches of selective adenosine receptor type 2A agonists as potential anti-inflammatory drugs
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, 2021;
FI:Not Available; Q4
1,2,3-Triazole tethered 2-mercaptobenzimidazole derivatives: design, synthesis and molecular assessment toward C6 glioma cell line
FUTURE MEDICINAL CHEMISTRY, 2020;
FI:3,607; Q2
Alkylated Sesamol Derivatives as Potent Antioxidants
MOLECULES, 2020;
FI:3,267; Q2
Identification of Novel Chemical Entities for Adenosine Receptor Type 2A Using Molecular Modeling Approaches
MOLECULES, 2020;
FI:3,267; Q2
Identification of Potential COX-2 Inhibitors for the Treatment of Inflammatory Diseases Using Molecular Modeling Approaches
MOLECULES, 2020;
FI:3,267; Q2
Design, synthesis and biological evaluation of novel vicinal diaryl-substituted 1H-Pyrazole analogues of combretastatin A-4 as highly potent tubulin polymerization inhibitors
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019;
FI:4,833; D1
In Silico Evaluation of Ibuprofen and Two Benzoylpropionic Acid Derivatives with Potential Anti-Inflammatory Activity
MOLECULES, 2019;
FI:3,06; Q2
Toward of Safer Phenylbutazone Derivatives by Exploration of Toxicity Mechanism
MOLECULES, 2019;
FI:3,06; Q2
Identification of New Inhibitors with Potential Antitumor Activity from Polypeptide Structures via Hierarchical Virtual Screening
MOLECULES, 2019;
FI:3,06; Q2
NMR studies of new heterocycles tethered to purine moieties with anticancer activity
MAGNETIC RESONANCE IN CHEMISTRY, 2019;
FI:1,731; Q3
Enhancement of Tumor Cell Death by Combining gef Gene Mediated Therapy and New 1,4-Benzoxazepin-2,6-Dichloropurine Derivatives in Breast Cancer Cells
FRONTIERS IN PHARMACOLOGY, 2018;
FI:3,831; Q1
Syntheses of non-aromatic medium and large rings synthesized via phenylnitrenium ions
ARABIAN JOURNAL OF CHEMISTRY, 2018;
FI:2,969; Q2
Cysteine-based 3-substituted 1,5-benzoxathiepin derivatives: Two new classes of anti-proliferative agents
ARABIAN JOURNAL OF CHEMISTRY, 2018;
FI:2,969; Q2
Development of Biotransamination Reactions towards the 3,4-Dihydro-2H-1,5-benzoxathiepin-3-amine Enantiomers
CATALYSTS, 2018;
FI:3,465; Q2
An In Silico Study of the Antioxidant Ability for Two Caffeine Analogs Using Molecular Docking and Quantum Chemical Methods
MOLECULES, 2018;
FI:3,098; Q2
1-(Benzenesulfonyl)-1,5-dihydro-4,1-benzoxazepine as a new scaffold for the design of antitumor compounds
FUTURE MEDICINAL CHEMISTRY, 2017;
FI:3,556; Q1
Antitumoral activity of 1,2-diaminocyclohexane derivatives in breast, colon and skin human cancer cells
FUTURE MEDICINAL CHEMISTRY, 2017;
FI:3,556; Q1
The use of wiki to promote students’ learning in higher education (Degree in Pharmacy)
INTERNATIONAL JOURNAL OF EDUCATIONAL TECHNOLOGY IN HIGHER EDUCATION, 2016;
Plasmodium falciparum Choline Kinase Inhibition Leads to a Major Decrease in Phosphatidylethanolamine Causing Parasite Death
SCIENTIFIC REPORTS, 2016;
FI:5,228; Q1
Inhibitors of Cancer Stem Cells
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, 2016;
FI:2,722; Q2
Metal binding pattern of acyclovir in ternary copper(II) complexes having an S-thioether or S-disulfide NO2S-tripodal tetradentate chelator
INORGANICA CHIMICA ACTA, 2016;
FI:1,918; Q2
H-1 and C-13 NMR spectral data of p-nitrobenzenesulfonamides and dansylsulfonamides derived from N-alkylated o-(purinemethyl)anilines
MAGNETIC RESONANCE IN CHEMISTRY, 2016;
FI:1,226; Q3
Imidazoles and Benzimidazoles as Tubulin-Modulators for Anti-Cancer Therapy
CURRENT MEDICINAL CHEMISTRY, 2015;
FI:3,853; D1
Design, synthesis and anti-leishmanial activity of novel symmetrical bispyridinium cyclophanes
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2015;
FI:3,447; Q1
p-Nitrobenzenesulfonamides and their fluorescent dansylsulfonamides derived from N-alkylated o-(purine-methyl)anilines as novel antitumour agents
RSC ADVANCES, 2015;
FI:3,84; Q1
Preclinical Characterization of RSM-932A, a Novel Anticancer Drug Targeting the Human Choline Kinase Alpha, an Enzyme Involved in Increased Lipid Metabolism of Cancer Cells
MOLECULAR CANCER THERAPEUTICS, 2015;
FI:5,683; Q1
Molecular recognition between adenine or 2,6-diaminopurine and copper(II) chelates with N,O-2,S-tripodal tetradentate chelators having thioether or disulfide donor groups
JOURNAL OF INORGANIC BIOCHEMISTRY, 2015;
FI:3,444; Q1
Design, synthesis, biological evaluation and targeted release of CD44 inhibitors: a promising antitumor therapy
Financiador: CONSEJERÍA DE TRANSFORMACIÓN ECONÓMICA, INDUSTRIA, CONOCIMIENTO Y UNIVERSIDADES
Número de expediente: P18-RT-1679
Tiempo de ejecución: 01/01/2020 - 31/03/2023
IP: ANA CONEJO GARCIA
Synthesis of lipophenols with anticancer activity from bioactive compounds from food byproducts
Financiador: AGENCIA ESTATAL DE INVESTIGACIÓN
Número de expediente: TED2021-132047B-I00
Tiempo de ejecución: 01/12/2022 - 30/11/2024
IP: ANA CONEJO GARCIA
Development of a new nanotechnology platform for antitumor therapy based on CD44 inhibition
Financiador: AGENCIA ESTATAL DE INVESTIGACIÓN
Número de expediente: PID2021-128109OB-I00
Tiempo de ejecución: 01/09/2022 - 31/08/2025
IP: ANA CONEJO GARCIA
Mejora de la actividad anticancerosa del bozepinib, bozinib y derivados, mediante la introducción del grupo trifluorometilo
Financiador: UNIVERSIDAD DE GRANADA
Número de expediente: CS2016-1
Tiempo de ejecución: 01/01/2017 - 31/10/2018
IP: JOAQUIN MARIA CAMPOS ROSA