The structural microarchitecture of soft tissue is recently becoming a cornerstone of biomechanical engineering and is of growing interest for a broad spectrum of clinical specialists. Our new ultrasonic wave concepts are enabling a new class of biomarkers for both imaging and controlling in vivo and noninvasively tissue microarchitecture. The breakthrough of modelling its elastic hierarchical complexity impacts critical aspects including organ-level functionality, inflammatory and healing processes, tumour growth, all the way down to cell-to-cell signalling. We have: a) Conceived and developed torsional ultrasonic waves and sensor technologies capable of generating and sensing them, prototyping robust functional instrumentation. b) Modelled relationships between the biochemical cascade and the mechanical functionality and their interaction with ultrasound, integrating models of tissue remodelling and tumour growth, experimentally validated by ultrasonication of cancer stem cells.
Lineas de investigación
Biomecánica y ensayos mecánicos de tejidos
Biorreactores sensorizados
Dispositivos médicos de diagnóstico por ultrasonidos y elastografía - aplicación a parto pretérmino
The Impact of Maternal Pre-Pregnancy Body Weight and Gestational Diabetes on Markers of Folate Metabolism in the Placenta.
Nutrients, 2018; 10(11);
FI: 4.171; Q1 / D3
Aranda E, García-Alfonso P, Benavides M, Sánchez Ruiz A, Guillén-Ponce C, Safont MJ, Alcaide J, Gómez A, López R, Manzano JL, Méndez Ureña M, Sastre J, Rivera F, Grávalos C, García T, Martín-Valadés JI, Falcó E, Navalón M, González Flores E, Ma García Tapiador A, Ma López Muñoz A, Barrajón E, Reboredo M, García Teijido P, Viudez A, Cárdenas N, Díaz-Rubio E, Spanish Cooperative Group for the Treatment of Digestive Tumours (TTD)
First-line mFOLFOX plus cetuximab followed by mFOLFOX plus cetuximab or single-agent cetuximab as maintenance therapy in patients with metastatic colorectal cancer: Phase II randomised MACRO2 TTD study.
European journal of cancer (Oxford, England : 1990), 2018; 101; 263-272
FI: 7.191; Q1 / D2
Tan MY, Syngelaki A, Poon LC, Rolnik DL, O'Gorman N, Delgado JL, Akolekar R, Konstantinidou L, Tsavdaridou M, Galeva S, Ajdacka U, Molina FS, Persico N, Jani JC, Plasencia W, Greco E, Papaioannou G, Wright A, Wright D, Nicolaides KH
Screening for pre-eclampsia by maternal factors and biomarkers at 11-13 weeks' gestation.
Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology, 2018; 52(2); 186-195
FI: 5.654; Q1 / D1
Tan MY, Poon LC, Rolnik DL, Syngelaki A, de Paco Matallana C, Akolekar R, Cicero S, Janga D, Singh M, Molina FS, Persico N, Jani JC, Plasencia W, Greco E, Papaioannou G, Wright D, Nicolaides KH
Prediction and prevention of small-for-gestational-age neonates: evidence from SPREE and ASPRE.
Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology, 2018; 52(1); 52-59
FI: 5.654; Q1 / D1
Wright D, Rolnik DL, Syngelaki A, de Paco Matallana C, Machuca M, de Alvarado M, Mastrodima S, Tan MY, Shearing S, Persico N, Jani JC, Plasencia W, Papaioannou G, Molina FS, Poon LC, Nicolaides KH
Aspirin for Evidence-Based Preeclampsia Prevention trial: effect of aspirin on length of stay in the neonatal intensive care unit.
American journal of obstetrics and gynecology, 2018; 218(6); 612.e1-612.e6
FI: 5.732; Q1 / D1
Sangrós FJ, Torrecilla J, Giráldez-García C, Carrillo L, Mancera J, Mur T, Franch J, Díez J, Goday A, Serrano R, García-Soidán FJ, Cuatrecasas G, Igual D, Moreno A, Millaruelo JM, Carramiñana F, Ruiz MA, Pérez FC, Iriarte Y, Lorenzo Á, González M, Álvarez B, Barutell L, Mayayo MS, Del Castillo M, Navarro E, Malo F, Cambra A, López R, Gutiérrez MÁ, Gutiérrez L, Boente C, Mediavilla JJ, Prieto L, Mendo L, Mansilla MJ, Ortega FJ, Borras A, Sánchez LG, Obaya JC, Alonso M, García F, Gutiérrez ÁT, Hernández AM, Suárez D, Álvarez JC, Sáenz I, Martínez FJ, Casorrán A, Ripoll J, Salanova A, Marín MT, Gutiérrez F, Innerárity J, Álvarez MDM, Artola S, Bedoya MJ, Poveda S, Álvarez F, Brito MJ, Iglesias R, Paniagua F, Nogales P, Gómez Á, Rubio JF, Durán MC, Sagredo J, Gijón MT, Rollán MÁ, Pérez PP, Gamarra J, Carbonell F, García-Giralda L, Antón JJ, de la Flor M, Martínez R, Pardo JL, Ruiz A, Plana R, Macía R, Villaró M, Babace C, Torres JL, Blanco C, Jurado Á, Martín JL, Navarro J, Sanz G, Colas R, Cordero B, de Castro C, Ibáñez M, Monzón A, Porta N, Gómez MDC, Llanes R, Rodríguez JJ, Granero E, Sánchez M, Martínez J, Ezkurra P, Ávila L, de la Sen C, Rodríguez A, Buil P, Gabriel P, Roura P, Tarragó E, Mundet X, Bosch R, González JC, Bobé MI, Mata M, Ruiz I, López F, Birules M, Armengol O, de Miguel RM, Romera L, Benito B, Piulats N, Bilbeny B, Cabré JJ, Cos X, Pujol R, Seguí M, Losada C, de Santiago AM, Muñoz P, Regidor E
Association of General and Abdominal Obesity With Hypertension, Dyslipidemia and Prediabetes in the PREDAPS Study.
Revista espanola de cardiologia (English ed.), 2018; 71(3); 170-177
FI: 5.166; Q1 / D2
Melchor, J; Lopez-Ruiz, E; Soto, J; Jimenez, G; Antich, C; Peran, M; Baena, JM; Marchal, JA; Rus, G
In-bioreactor ultrasonic monitoring of 3D culture human engineered cartilage
SENSORS AND ACTUATORS B-CHEMICAL, 2018; 266;
FI: 5.667; Q1 / D1
Massó P, Rus G, Molina FS
Safety of elastography in fetal medicine: preliminary study on hypoacusis.
Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology, 2017; 50(5); 660-661
FI: 5.654; Q1 / D1
Rolnik DL, Wright D, Poon LCY, Syngelaki A, O'Gorman N, de Paco Matallana C, Akolekar R, Cicero S, Janga D, Singh M, Molina FS, Persico N, Jani JC, Plasencia W, Papaioannou G, Tenenbaum-Gavish K, Nicolaides KH
ASPRE trial: performance of screening for preterm pre-eclampsia.
Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology, 2017; 50(4); 492-495
FI: 5.654; Q1 / D1
Rolnik DL, Wright D, Poon LC, O'Gorman N, Syngelaki A, de Paco Matallana C, Akolekar R, Cicero S, Janga D, Singh M, Molina FS, Persico N, Jani JC, Plasencia W, Papaioannou G, Tenenbaum-Gavish K, Meiri H, Gizurarson S, Maclagan K, Nicolaides KH
Aspirin versus Placebo in Pregnancies at High Risk for Preterm Preeclampsia.
The New England journal of medicine, 2017; 377(7); 613-622
FI: 79.26; Q1 / D1
Peralta L, Molina FS, Melchor J, Gómez LF, Massó P, Florido J, Rus G
Transient Elastography to Assess the Cervical Ripening during Pregnancy: A Preliminary Study.
Ultraschall in der Medizin (Stuttgart, Germany : 1980), 2017; 38(4); 395-402
FI: 4.389; Q1 / D2
O'Gorman N, Wright D, Poon LC, Rolnik DL, Syngelaki A, Wright A, Akolekar R, Cicero S, Janga D, Jani J, Molina FS, de Paco Matallana C, Papantoniou N, Persico N, Plasencia W, Singh M, Nicolaides KH
Accuracy of competing-risks model in screening for pre-eclampsia by maternal factors and biomarkers at 11-13 weeks' gestation.
Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology, 2017; 49(6); 751-755
FI: 5.654; Q1 / D1
López-Ruiz E, Venkateswaran S, Perán M, Jiménez G, Pernagallo S, Díaz-Mochón JJ, Tura-Ceide O, Arrebola F, Melchor J, Soto J, Rus G, Real PJ, Diaz-Ricart M, Conde-González A, Bradley M, Marchal JA
Poly(ethylmethacrylate-co-diethylaminoethyl acrylate) coating improves endothelial re-population, bio-mechanical and anti-thrombogenic properties of decellularized carotid arteries for blood vessel replacement.
Scientific reports, 2017; 7(1); 407
FI: 4.122; Q1 / D2
Título del proyecto: Ultrasonidos de Torsión para Diagnóstico de Parto Pretérmino y Predicción del Éxito en la Inducción.
Financiador: CONSEJERIA DE SALUD
Nº Expediente: PI-0107-2017
Ejecución: 2018-2020
IP: JUAN MANUEL MELCHOR RODRIGUEZ
Título del proyecto: Impacto de la detección y tratamiento precoz de las gestantes portadoras asintomáticas de vaginosis bacteriana, en la tasa de parto pretérmino (VB-PREM)
Financiador: INSTITUTO DE SALUD CARLOS III
Nº Expediente: PI17/01881
Ejecución: 2018-2020
IP: OTILIA RUTH GONZALEZ VANEGAS
Título del proyecto: Dispositivo de diagnóstico de cáncer de próstata por ondas mecánicas.
Financiador: FUNDACIÓN PÚBLICA PARA LA INVESTIGACIÓN BIOSANITARIA DE ANDALUCIA ORIENTAL ALEJANDRO OTERO (FIBAO)
Nº Expediente: INB-0010
Ejecución: 2017-2019
IP: GUILLERMO RUS CARLSBORG
Título del proyecto: PI16/00339 PREDICCIÓN DEL PARTO POR ELASTOGRAFÍA ULTRASÓNICA
