FARMACOLOGÍA CARDIOVASCULAR
Grupos de investigación IBS-MP-02
FARMACOLOGÍA CARDIOVASCULAR
Nuestras líneas de investigación tienen como objetivos generales: estudiar el papel del sistema inmune en la disfunción endotelial en hipertensión, buscar estrategias de modulación de la flora intestinal y su impacto integral en el control de la presión arterial. En ambos casos colaboramos con el Hospital Universitario Virgen de la Nieves de Granada y con empresas como Biosearch SA y con el Centro Tecnológico de Investigación y Desarrollo del Alimento Funcional (CIDAF).
Lineas de investigación
Palabras clave
| Miembro |
|---|
| GÓMEZ GUZMÁN, MANUEL |
| SÁNCHEZ SANTOS, MANUEL |
| DUARTE PÉREZ, JUAN MANUEL |
| ROMERO PÉREZ, MIGUEL |
| JIMÉNEZ MOLEÓN, ROSARIO |
Robles-Vera I, Toral M, de la Visitación N, Sánchez M, Romero M, Olivares M, Jiménez R, Duarte J
The Probiotic Lactobacillus fermentum Prevents Dysbiosis and Vascular Oxidative Stress in Rats with Hypertension Induced by Chronic Nitric Oxide Blockade.
Molecular nutrition & food research, 2018; 62(19); e1800298
FI: 5.151; Q1 / D1
Gómez-Guzmán M, Rodríguez-Nogales A, Algieri F, Gálvez J
Potential Role of Seaweed Polyphenols in Cardiovascular-Associated Disorders.
Marine drugs, 2018; 16(8);
FI: 4.379; Q1 / D1
I Robles, M Toral, N De la Visitación, M Sánchez, M Romero, M Olivares, R Jiménez, J Duarte
The probiotic Lactobacillus fermentum prevents dysbiosis and vascular oxidative stress in rats with hypertension induced by chronic nitric oxide blockade
Molecular Nutrition and Food Research, 2018; ;
FI: 5.151; Q1 / D1
Callejo M, Mondejar-Parreño G, Barreira B, Izquierdo-Garcia JL, Morales-Cano D, Esquivel-Ruiz S, Moreno L, Cogolludo Á, Duarte J, Perez-Vizcaino F
Pulmonary Arterial Hypertension Affects the Rat Gut Microbiome.
Scientific reports, 2018; 8(1); 9681
FI: 4.122; Q1 / D2
Toral M, Romero M, Rodríguez-Nogales A, Jiménez R, Robles-Vera I, Algieri F, Chueca-Porcuna N, Sánchez M, de la Visitación N, Olivares M, García F, Pérez-Vizcaíno F, Gálvez J, Duarte J
Lactobacillus fermentum Improves Tacrolimus-Induced Hypertension by Restoring Vascular Redox State and Improving eNOS Coupling.
Molecular nutrition & food research, 2018; ; e1800033
FI: 5.151; Q1 / D1
M Toral, M Romero, A Rogriguez-Nogales, R Jiménez, I Robles-Vera, F Algieri, N Chueca-Porcuna, M Sanchez, N de la Visitación, M Olivares, F Garcia, F Perez-Vizcaino, J Galvez, JM Duarte
Lactobacillus fermentum improves tacrolimus-induced hypertension by restoring vascular redox state and improving eNOS coupling
Molecular Nutrition & Food Research, 2018; 62;
FI: 5.151; Q1 / D1
Sangrós FJ, Torrecilla J, Giráldez-García C, Carrillo L, Mancera J, Mur T, Franch J, Díez J, Goday A, Serrano R, García-Soidán FJ, Cuatrecasas G, Igual D, Moreno A, Millaruelo JM, Carramiñana F, Ruiz MA, Pérez FC, Iriarte Y, Lorenzo Á, González M, Álvarez B, Barutell L, Mayayo MS, Del Castillo M, Navarro E, Malo F, Cambra A, López R, Gutiérrez MÁ, Gutiérrez L, Boente C, Mediavilla JJ, Prieto L, Mendo L, Mansilla MJ, Ortega FJ, Borras A, Sánchez LG, Obaya JC, Alonso M, García F, Gutiérrez ÁT, Hernández AM, Suárez D, Álvarez JC, Sáenz I, Martínez FJ, Casorrán A, Ripoll J, Salanova A, Marín MT, Gutiérrez F, Innerárity J, Álvarez MDM, Artola S, Bedoya MJ, Poveda S, Álvarez F, Brito MJ, Iglesias R, Paniagua F, Nogales P, Gómez Á, Rubio JF, Durán MC, Sagredo J, Gijón MT, Rollán MÁ, Pérez PP, Gamarra J, Carbonell F, García-Giralda L, Antón JJ, de la Flor M, Martínez R, Pardo JL, Ruiz A, Plana R, Macía R, Villaró M, Babace C, Torres JL, Blanco C, Jurado Á, Martín JL, Navarro J, Sanz G, Colas R, Cordero B, de Castro C, Ibáñez M, Monzón A, Porta N, Gómez MDC, Llanes R, Rodríguez JJ, Granero E, Sánchez M, Martínez J, Ezkurra P, Ávila L, de la Sen C, Rodríguez A, Buil P, Gabriel P, Roura P, Tarragó E, Mundet X, Bosch R, González JC, Bobé MI, Mata M, Ruiz I, López F, Birules M, Armengol O, de Miguel RM, Romera L, Benito B, Piulats N, Bilbeny B, Cabré JJ, Cos X, Pujol R, Seguí M, Losada C, de Santiago AM, Muñoz P, Regidor E
Association of General and Abdominal Obesity With Hypertension, Dyslipidemia and Prediabetes in the PREDAPS Study.
Revista espanola de cardiologia (English ed.), 2018; 71(3); 170-177
FI: 5.166; Q1 / D2
M Toral, R Jimenez, M Romero, I Robles-Vera, M Sanchez, M Salaices, JM Sabio, J Duarte
Role of endoplasmic reticulum stress in the protective effects of PPARB/D activation on endothelial dysfunction induced by plasma from patients with lupus
Arthritis research and therapy, 2017; 19; 268
FI: 4.269; Q1 / D3
Recoquillon S, Gómez-Guzmán M, Rodier M, Koffi C, Nitiéma M, Gagnadoux F, Martínez MC, Andriantsitohaina R
Non-muscular myosin light chain kinase triggers intermittent hypoxia-induced interleukin-6 release, endothelial dysfunction and permeability.
Scientific reports, 2017; 7(1); 13664
FI: 4.122; Q1 / D2
Mahmoud AM, Wilkinson FL, McCarthy EM, Moreno-Martinez D, Langford-Smith A, Romero M, Duarte J, Alexander MY
Akt/eNOS signaling and reduced oxidative stress.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2017; 31(10); 4636-4648
FI: 5.595; Q1 / D2
Díaz-de-Cerio E, Rodríguez-Nogales A, Algieri F, Romero M, Verardo V, Segura-Carretero A, Duarte J, Galvez J
The hypoglycemic effects of guava leaf (Psidium guajava L.) extract are associated with improving endothelial dysfunction in mice with diet-induced obesity.
Food research international (Ottawa, Ont.), 2017; 96; 64-71
FI: 3.52; Q1 / D2
Romero M, Toral M, Robles-Vera I, Sánchez M, Jiménez R, O'Valle F, Rodriguez-Nogales A, Pérez-Vizcaino F, Gálvez J, Duarte J
Activation of Peroxisome Proliferator Activator Receptor β/δ Improves Endothelial Dysfunction and Protects Kidney in Murine Lupus.
Hypertension (Dallas, Tex. : 1979), 2017; 69(4); 641-650
FI: 6.823; Q1 / D1
M. Romero, M. Toral, I. Vera-Robles, M. Sanchez, R. Jiménez, F. O'Valle, A. Rodríguez-Nogales, F. Pérez-Vizcaino, J. Gálvez, J. Duarte
Activation of Peroxisome Proliferator Activator Receptor beta/delta Improves Endothelial Dysfunction and Protects Kidney in Murine Lupus
Hypertension, 2017; 69; 641-650
FI: 6.823; Q1 / D1
Quesada A, Segarra AB, Montoro-Molina S, de Gracia MD, Osuna A, O'Valle F, Gómez-Guzmán M, Vargas F, Wangensteen R
Glutamyl aminopeptidase in microvesicular and exosomal fractions of urine is related with renal dysfunction in cisplatin-treated rats.
PloS one, 2017; 12(4); e0175462
FI: 2.766; Q1 / D3
Luna-Sánchez M, Hidalgo-Gutiérrez A, Hildebrandt TM, Chaves-Serrano J, Barriocanal-Casado E, Santos-Fandila Á, Romero M, Sayed RK, Duarte J, Prokisch H, Schuelke M, Distelmaier F, Escames G, Acuña-Castroviejo D, López LC
CoQ deficiency causes disruption of mitochondrial sulfide oxidation, a new pathomechanism associated with this syndrome.
EMBO molecular medicine, 2017; 9(1); 78-95
FI: 10.293; Q1 / D1
Mahmoud AM, Wilkinson FL, Jones AM, Wilkinson JA, Romero M, Duarte J, Alexander MY
A novel role for small molecule glycomimetics in the protection against lipid-induced endothelial dysfunction: Involvement of Akt/eNOS and Nrf2/ARE signaling.
Biochimica et biophysica acta. General subjects, 2017; 1861(1 Pt A); 3311-3322
FI: 3.679; Q1 / D3
Morales-Cano D, Moreno L, Barreira B, Briones AM, Pandolfi R, Moral-Sanz J, Callejo M, Mondejar-Parreño G, Cortijo J, Salaices M, Duarte J, Perez-Vizcaino F, Cogolludo A
Activation of PPARβ/δ prevents hyperglycaemia-induced impairment of Kv7 channels and cAMP-mediated relaxation in rat coronary arteries.
Clinical science (London, England : 1979), 2016; 130(20); 1823-36
FI: 4.936; Q1 / D2
Miguel Romero, Rosario Jimenez, Marta Toral, Elvira Leon-Gomez, Manuel Gomez-Guzman, Manuel Sanchez, Maria Jose Zarzuelo, Isabel Rodriguez-Gomez, Geraldine Rath, Juan Tamargo, Francisco Perez-Vizcaino, Chantal Dessy, Juan Duarte
Vascular and Central Activation of Peroxisome Proliferator-Activated Receptor-beta Attenuates Angiotensin II-Induced Hypertension: Role of RGS-5.
The Journal of pharmacology and experimental therapeutics., 2016; 358; 151-163
FI: 3.867; Q1 / D2
Toral M, Romero M, Jiménez R, Robles-Vera I, Tamargo J, Martínez MC, Pérez-Vizcaíno F, Duarte J
Role of UCP2 in the protective effects of PPARβ/δ activation on lipopolysaccharide-induced endothelial dysfunction.
Biochemical pharmacology, 2016; 110-111; 25-36
FI: 4.581; Q1 / D2
Romero M, Leon-Gomez E, Lobysheva I, Rath G, Dogné JM, Feron O, Dessy C
Effects of BM-573 on Endothelial Dependent Relaxation and Increased Blood Pressure at Early Stages of Atherosclerosis.
PloS one, 2016; 11(3); e0152579
FI: 2.806; Q1 / D3
Romero M, Toral M, Gómez-Guzmán M, Jiménez R, Galindo P, Sánchez M, Olivares M, Gálvez J, Duarte J
Antihypertensive effects of oleuropein-enriched olive leaf extract in spontaneously hypertensive rats.
Food & function, 2016; 7(1); 584-93
FI: 3.247; Q1 / D2
Toral M, Romero M, Jiménez R, Mahmoud AM, Barroso E, Gómez-Guzmán M, Sánchez M, Cogolludo Á, García-Redondo AB, Briones AM, Vázquez-Carrera M, Pérez-Vizcaíno F, Duarte J
Carnitine palmitoyltransferase-1 up-regulation by PPAR-β/δ prevents lipid-induced endothelial dysfunction.
Clinical science (London, England : 1979), 2015; 129(9); 823-37
FI: 5.016; Q1 / D2
Gómez-Guzmán M, Toral M, Romero M, Jiménez R, Galindo P, Sánchez M, Zarzuelo MJ, Olivares M, Gálvez J, Duarte J
Antihypertensive effects of probiotics Lactobacillus strains in spontaneously hypertensive rats.
Molecular nutrition & food research, 2015; 59(11); 2326-36
FI: 4.551; Q1 / D1
Toral M, Gómez-Guzmán M, Jiménez R, Romero M, Zarzuelo MJ, Utrilla MP, Hermenegildo C, Cogolludo Á, Pérez-Vizcaíno F, Gálvez J, Duarte J
Chronic peroxisome proliferator-activated receptorβ/δ agonist GW0742 prevents hypertension, vascular inflammatory and oxidative status, and endothelial dysfunction in diet-induced obesity.
Journal of hypertension, 2015; 33(9); 1831-44
FI: 5.062; Q1 / D2
Morales-Cano D, Moreno L, Barreira B, Pandolfi R, Chamorro V, Jimenez R, Villamor E, Duarte J, Perez-Vizcaino F, Cogolludo A
Kv7 channels critically determine coronary artery reactivity: left-right differences and down-regulation by hyperglycaemia.
Cardiovascular research, 2015; 106(1); 98-108
FI: 5.465; Q1 / D2
Jimenez R, Lopez-Sepulveda R, Romero M, Toral M, Cogolludo A, Perez-Vizcaino F, Duarte J
Quercetin and its metabolites inhibit the membrane NADPH oxidase activity in vascular smooth muscle cells from normotensive and spontaneously hypertensive rats.
Food & function, 2015; 6(2); 409-14
FI: 2.686; Q1 / D2
Tamargo J, Duarte J, Ruilope LM
New antihypertensive drugs under development.
Current medicinal chemistry, 2015; 22(3); 305-42
FI: 3.455; Q1 / D2
López-Farré AJ, Rodriguez-Sierra P, Modrego J, Segura A, Martín-Palacios N, Saiz AM, Zamorano-León JJ, Duarte J, Serrano J, Moñux G
Effects of factor Xa on the expression of proteins in femoral arteries from type 2 diabetic patients.
British journal of clinical pharmacology, 2014; 78(6); 1366-77
FI: 3.878; Q1 / D2
Perez A, Gonzalez-Manzano S, Jimenez R, Perez-Abud R, Haro JM, Osuna A, Santos-Buelga C, Duarte J, Perez-Vizcaino F
The flavonoid quercetin induces acute vasodilator effects in healthy volunteers: correlation with beta-glucuronidase activity.
Pharmacological research, 2014; 89; 11-8
FI: 4.408; Q1 / D2
Duarte J, Francisco V, Perez-Vizcaino F
Modulation of nitric oxide by flavonoids.
Food & function, 2014; 5(8); 1653-68
FI: 2.791; Q1 / D2
Gómez-Guzmán M, Jiménez R, Romero M, Sánchez M, Zarzuelo MJ, Gómez-Morales M, O'Valle F, López-Farré AJ, Algieri F, Gálvez J, Pérez-Vizcaino F, Sabio JM, Duarte J
Chronic hydroxychloroquine improves endothelial dysfunction and protects kidney in a mouse model of systemic lupus erythematosus.
Hypertension, 2014; 64(2); 330-7
FI: 6.48; Q1 / D1
Toral M, Gómez-Guzmán M, Jiménez R, Romero M, Sánchez M, Utrilla MP, Garrido-Mesa N, Rodríguez-Cabezas ME, Olivares M, Gálvez J, Duarte J
The probiotic Lactobacillus coryniformis CECT5711 reduces the vascular pro-oxidant and pro-inflammatory status in obese mice.
Clinical science (London, England : 1979), 2014; 127(1); 33-45
FI: 5.598; Q1 / D1
Quintela AM, Jiménez R, Piqueras L, Gómez-Guzmán M, Haro J, Zarzuelo MJ, Cogolludo A, Sanz MJ, Toral M, Romero M, Pérez-Vizcaíno F, Duarte J
PPARβ activation restores the high glucose-induced impairment of insulin signalling in endothelial cells.
British journal of pharmacology, 2014; 171(12); 3089-102
FI: 4.842; Q1 / D1
Montiel V, Leon Gomez E, Bouzin C, Esfahani H, Romero Perez M, Lobysheva I, Devuyst O, Dessy C, Balligand JL
Genetic deletion of aquaporin-1 results in microcardia and low blood pressure in mouse with intact nitric oxide-dependent relaxation, but enhanced prostanoids-dependent relaxation.
Pflügers Archiv : European journal of physiology, 2014; 466(2); 237-51
FI: 4.101; Q1 / D2
Morales-Cano D, Menendez C, Moreno E, Moral-Sanz J, Barreira B, Galindo P, Pandolfi R, Jimenez R, Moreno L, Cogolludo A, Duarte J, Perez-Vizcaino F
The flavonoid quercetin reverses pulmonary hypertension in rats.
PloS one, 2014; 9(12); e114492
FI: 3.234; Q1 / D2
Zarzuelo MJ, Gómez-Guzmán M, Jiménez R, Quintela AM, Romero M, Sánchez M, Zarzuelo A, Tamargo J, Pérez-Vizcaíno F, Duarte J
Effects of peroxisome proliferator-activated receptor-β activation in endothelin-dependent hypertension.
Cardiovascular research, 2013; 99(4); 622-31
FI: 5.808; Q1 / D2
Zarzuelo MJ, López-Sepúlveda R, Sánchez M, Romero M, Gómez-Guzmán M, Ungvary Z, Pérez-Vizcaíno F, Jiménez R, Duarte J
SIRT1 inhibits NADPH oxidase activation and protects endothelial function in the rat aorta: implications for vascular aging.
Biochemical pharmacology, 2013; 85(9); 1288-96
FI: 4.65; Q1 / D1
Jiménez R, Duarte J, Perez-Vizcaino F
Epicatechin: endothelial function and blood pressure.
Journal of agricultural and food chemistry, 2012; 60(36); 8823-30
FI: 2.906; Q1 / D1
Rath G, Saliez J, Behets G, Romero-Perez M, Leon-Gomez E, Bouzin C, Vriens J, Nilius B, Feron O, Dessy C
Vascular hypoxic preconditioning relies on TRPV4-dependent calcium influx and proper intercellular gap junctions communication.
Arteriosclerosis, thrombosis, and vascular biology, 2012; 32(9); 2241-9
FI: 6.338; Q1 / D1
Quintela AM, Jiménez R, Gómez-Guzmán M, Zarzuelo MJ, Galindo P, Sánchez M, Vargas F, Cogolludo A, Tamargo J, Pérez-Vizcaíno F, Duarte J
Activation of peroxisome proliferator-activated receptor-β/-δ (PPARβ/δ) prevents endothelial dysfunction in type 1 diabetic rats.
Free radical biology & medicine, 2012; 53(4); 730-41
FI: 5.271; Q1 / D2
Li Y, Wang H, Tarus B, Perez MR, Morellato L, Henry E, Berka V, Tsai AL, Ramassamy B, Dhimane H, Dessy C, Tauc P, Boucher JL, Deprez E, Slama-Schwok A
Rational design of a fluorescent NADPH derivative imaging constitutive nitric-oxide synthases upon two-photon excitation.
Proceedings of the National Academy of Sciences of the United States of America, 2012; 109(31); 12526-31
FI: 9.737; Q1 / D1
Perez-Vizcaino F, Duarte J, Santos-Buelga C
The flavonoid paradox: conjugation and deconjugation as key steps for the biological activity of flavonoids.
Journal of the science of food and agriculture, 2012; 92(9); 1822-5
FI: 1.759; Q1 / D1
Galindo P, González-Manzano S, Zarzuelo MJ, Gómez-Guzmán M, Quintela AM, González-Paramás A, Santos-Buelga C, Pérez-Vizcaíno F, Duarte J, Jiménez R
Different cardiovascular protective effects of quercetin administered orally or intraperitoneally in spontaneously hypertensive rats.
Food & function, 2012; 3(6); 643-50
FI: 2.694; Q1 / D2
Galindo P, Rodriguez-Gómez I, González-Manzano S, Dueñas M, Jiménez R, Menéndez C, Vargas F, Tamargo J, Santos-Buelga C, Pérez-Vizcaíno F, Duarte J
Glucuronidated quercetin lowers blood pressure in spontaneously hypertensive rats via deconjugation.
PloS one, 2012; 7(3); e32673
FI: 3.73; Q1 / D2
Gómez-Guzmán M, Jiménez R, Sánchez M, Zarzuelo MJ, Galindo P, Quintela AM, López-Sepúlveda R, Romero M, Tamargo J, Vargas F, Pérez-Vizcaíno F, Duarte J
Epicatechin lowers blood pressure, restores endothelial function, and decreases oxidative stress and endothelin-1 and NADPH oxidase activity in DOCA-salt hypertension.
Free radical biology & medicine, 2012; 52(1); 70-9
FI: 5.271; Q1 / D2
Menendez C, Dueñas M, Galindo P, González-Manzano S, Jimenez R, Moreno L, Zarzuelo MJ, Rodríguez-Gómez I, Duarte J, Santos-Buelga C, Perez-Vizcaino F
Vascular deconjugation of quercetin glucuronide: the flavonoid paradox revealed?
Molecular nutrition & food research, 2011; 55(12); 1780-90
FI: 4.301; Q1 / D1
Gómez-Guzmán M, Jiménez R, Sánchez M, Romero M, O'Valle F, Lopez-Sepulveda R, Quintela AM, Galindo P, Zarzuelo MJ, Bailón E, Delpón E, Perez-Vizcaino F, Duarte J
Chronic (-)-epicatechin improves vascular oxidative and inflammatory status but not hypertension in chronic nitric oxide-deficient rats.
The British journal of nutrition, 2011; 106(9); 1337-48
FI: 3.013; Q1 / D3
Zarzuelo MJ, Jiménez R, Galindo P, Sánchez M, Nieto A, Romero M, Quintela AM, López-Sepúlveda R, Gómez-Guzmán M, Bailón E, Rodríguez-Gómez I, Zarzuelo A, Gálvez J, Tamargo J, Pérez-Vizcaíno F, Duarte J
Antihypertensive effects of peroxisome proliferator-activated receptor-β activation in spontaneously hypertensive rats.
Hypertension, 2011; 58(4); 733-43
FI: 6.207; Q1 / D1
Menendez C, Jimenez R, Moreno L, Galindo P, Cogolludo A, Duarte J, Perez-Vizcaino F
Lack of synergistic interaction between quercetin and catechin in systemic and pulmonary vascular smooth muscle.
The British journal of nutrition, 2011; 105(9); 1287-93
FI: 3.013; Q1 / D3
López-Sepúlveda R, Gómez-Guzmán M, Zarzuelo MJ, Romero M, Sánchez M, Quintela AM, Galindo P, O'Valle F, Tamargo J, Pérez-Vizcaíno F, Duarte J, Jiménez R
Red wine polyphenols prevent endothelial dysfunction induced by endothelin-1 in rat aorta: role of NADPH oxidase.
Clinical science (London, England : 1979), 2011; 120(8); 321-33
FI: 4.317; Q1 / D2
Ungvari Z, Bailey-Downs L, Gautam T, Jimenez R, Losonczy G, Zhang C, Ballabh P, Recchia FA, Wilkerson DC, Sonntag WE, Pearson K, de Cabo R, Csiszar A
Adaptive induction of NF-E2-related factor-2-driven antioxidant genes in endothelial cells in response to hyperglycemia.
American journal of physiology. Heart and circulatory physiology, 2011; 300(4); H1133-40
FI: 3.708; Q1 / D2
Perez-Vizcaino F, Duarte J
Flavonols and cardiovascular disease.
Molecular aspects of medicine, 2010; 31(6); 478-94
FI: 10.552; Q1 / D1
Romero M, Jiménez R, Sánchez M, López-Sepúlveda R, Zarzuelo A, Tamargo J, Pérez-Vizcaíno F, Duarte J
Vascular superoxide production by endothelin-1 requires Src non-receptor protein tyrosine kinase and MAPK activation.
Atherosclerosis, 2010; 212(1); 78-85
FI: 4.086; Q1 / D2
Caballero R, Dolz-Gaitón P, Gómez R, Amorós I, Barana A, González de la Fuente M, Osuna L, Duarte J, López-Izquierdo A, Moraleda I, Gálvez E, Sánchez-Chapula JA, Tamargo J, Delpón E
Flecainide increases Kir2.1 currents by interacting with cysteine 311, decreasing the polyamine-induced rectification.
Proceedings of the National Academy of Sciences of the United States of America, 2010; 107(35); 15631-6
FI: 9.771; Q1 / D1
Jiménez R, Sánchez M, Zarzuelo MJ, Romero M, Quintela AM, López-Sepúlveda R, Galindo P, Gómez-Guzmán M, Haro JM, Zarzuelo A, Pérez-Vizcaíno F, Duarte J
Endothelium-dependent vasodilator effects of peroxisome proliferator-activated receptor beta agonists via the phosphatidyl-inositol-3 kinase-Akt pathway.
The Journal of pharmacology and experimental therapeutics, 2010; 332(2); 554-61
FI: 4.017; Q1 / D2
Csiszar A, Labinskyy N, Jimenez R, Pinto JT, Ballabh P, Losonczy G, Pearson KJ, de Cabo R, Ungvari Z
Anti-oxidative and anti-inflammatory vasoprotective effects of caloric restriction in aging: role of circulating factors and SIRT1.
Mechanisms of ageing and development, 2009; 130(8); 518-27
FI: 4.179; Q1 / D2
Lodi F, Jimenez R, Moreno L, Kroon PA, Needs PW, Hughes DA, Santos-Buelga C, Gonzalez-Paramas A, Cogolludo A, Lopez-Sepulveda R, Duarte J, Perez-Vizcaino F
Glucuronidated and sulfated metabolites of the flavonoid quercetin prevent endothelial dysfunction but lack direct vasorelaxant effects in rat aorta.
Atherosclerosis, 2009; 204(1); 34-9
FI: 4.522; Q1 / D2
Romero M, Jiménez R, Sánchez M, López-Sepúlveda R, Zarzuelo MJ, O'Valle F, Zarzuelo A, Pérez-Vizcaíno F, Duarte J
Quercetin inhibits vascular superoxide production induced by endothelin-1: Role of NADPH oxidase, uncoupled eNOS and PKC.
Atherosclerosis, 2009; 202(1); 58-67
FI: 4.522; Q1 / D2
López-Sepúlveda R, Jiménez R, Romero M, Zarzuelo MJ, Sánchez M, Gómez-Guzmán M, Vargas F, O'Valle F, Zarzuelo A, Pérez-Vizcaíno F, Duarte J
Wine polyphenols improve endothelial function in large vessels of female spontaneously hypertensive rats.
Hypertension, 2008; 51(4); 1088-95
FI: 7.368; Q1 / D1
Galisteo M, Duarte J, Zarzuelo A
Effects of dietary fibers on disturbances clustered in the metabolic syndrome.
The Journal of nutritional biochemistry, 2008; 19(2); 71-84
FI: 4.352; Q1 / D1
Vera R, Jiménez R, Lodi F, Sánchez M, Galisteo M, Zarzuelo A, Pérez-Vizcaíno F, Duarte J
Genistein restores caveolin-1 and AT-1 receptor expression and vascular function in large vessels of ovariectomized hypertensive rats.
Menopause (New York, N.Y.), 2007; 14(5); 933-40
FI: 3.672; Q1 / D1
Jiménez R, López-Sepúlveda R, Kadmiri M, Romero M, Vera R, Sánchez M, Vargas F, O'Valle F, Zarzuelo A, Dueñas M, Santos-Buelga C, Duarte J
Polyphenols restore endothelial function in DOCA-salt hypertension: role of endothelin-1 and NADPH oxidase.
Free radical biology & medicine, 2007; 43(3); 462-73
FI: 4.813; Q1 / D1
Sanchez M, Lodi F, Vera R, Villar IC, Cogolludo A, Jimenez R, Moreno L, Romero M, Tamargo J, Perez-Vizcaino F, Duarte J
Quercetin and isorhamnetin prevent endothelial dysfunction, superoxide production, and overexpression of p47phox induced by angiotensin II in rat aorta.
The Journal of nutrition, 2007; 137(4); 910-5
FI: 3.771; Q1 / D1
Vera R, Sánchez M, Galisteo M, Villar IC, Jimenez R, Zarzuelo A, Pérez-Vizcaíno F, Duarte J
Chronic administration of genistein improves endothelial dysfunction in spontaneously hypertensive rats: involvement of eNOS, caveolin and calmodulin expression and NADPH oxidase activity.
Clinical science (London, England : 1979), 2007; 112(3); 183-91
FI: 3.9; Q1 / D1
Título del proyecto: Mecanismos gene´ticos de los efectos vasculares, renales y metabo´licos de los agonistas de receptores activados por proliferador de peroxisomas (PPAR)-beta/delta en el lupus eritematoso siste´mico
Financiador: CONSEJERIA DE ECONOMIA, INNOVACION, CIENCIA Y EMPLEO
Nº Expediente: IBS-P12-CTS-2722
Ejecución: 2014-2017
IP: JUAN MANUEL DUARTE
Título del proyecto: EFECTOS CARDIOVASCULARES DE AGONISTAS DE LOS RECEPTORES ACTIVADOS POR PROLIFERADOR DE PEROXISOMAS (PPAR)?/? EN MODELOS DE DIABETES EXPERIMENTAL
Financiador: MINISTERIO DE ECONOMIA Y COMPETITIVIDAD
Nº Expediente: IBS-SAF2010-22066-C02-01
Ejecución: 2011-2013
IP: JUAN MANUEL DUARTE
Título del proyecto: BIODISPONIBILIDAD Y EFECTO ANTIHIPERTENSIVO DE QUERCETINA
Financiador: MINISTERIO DE ECONOMIA Y COMPETITIVIDAD
Nº Expediente: IBS-AGL2007-66108-C04-03/ALI
Ejecución: 2007-2010
IP: ROSARIO JIMÉNEZ
Título del proyecto: PAPEL DE LOS RECEPTORES ACTIVADOS POR PROLIFERADOR DE PEROXISOMAS (PPAR)BETA/DELTA EN EL CONTROL DE LA FUNCION VASCULAR Y DE LA HIPERTENSION ARTERIAL
Financiador: MINISTERIO DE ECONOMIA Y COMPETITIVIDAD
Nº Expediente: IBS-SAF2007-62731
Ejecución: 2007-2010
IP: JUAN MANUEL DUARTE
Título del proyecto: DETERMINANTES GENÉTICOS Y AMBIENTALES DE LA DISFUNCIÓN VASCULAR EN LA HIPERTENSIÓN Y EN LA CARDIOPATÍA ISQUÉMICA: RED HERACLES
Financiador: Instituto de Salud Carlos III
Nº Expediente: IBS-RD06/0009/0006
Ejecución: 2007-2012
IP: JUAN MANUEL DUARTE
Título del proyecto: POLIFENOLES DE LA DIETA: FUNCIÓN ENDOTELIAL, INFLAMACIÓN VASCULAR Y ANGIOGÉNESIS
Financiador: CONSEJERIA DE ECONOMIA, INNOVACION, CIENCIA Y EMPLEO
Nº Expediente: IBS-P06-CTS-01555
Ejecución: 2007-2010
IP: JUAN MANUEL DUARTE
Título del ensayo: Ensayo clínico en fase IV para evaluar la eficacia de aflibercept en pacientes naive con lesiones de proliferación angiomatosa de la retina (RAP) en régimen de tratamiento individualizado Treat and Extend (TAE). Estudio AFLIRAP
Tipo de ensayo: ENSAYO CLINICO INDEPENDIENTE
Financiador: INSTITUT D'INVESTIGACIÓ BIOMÈDICA DE BELLVITGE (IDIBELL)
Nº Expediente: 2014-000300-10
Ejecución: 2014-2017
IP: ANTONIO JOSE GOMEZ ESCOBAR
