de la Visitación N, Robles-Vera I, Toral M, Duarte J

Protective Effects of Probiotic Consumption in Cardiovascular Disease in Systemic Lupus Erythematosus.

Nutrients, 2019; 11(11);

Pericà S JM, Llopis J, González-Ramallo V, Goenaga MÁ, Muñoz P, García-Leoni ME, Fariñas MC, Pajarón M, Ambrosioni J, Luque R, Goikoetxea J, Oteo JA, Carrizo E, Bodro M, Reguera-Iglesias JM, Navas E, Hidalgo-Tenorio C, Miró JM, Spanish Collaboration on Endocarditis-Grupo de Apoyo al Manejo de la Endocarditis Infecciosa en España (GAMES) investigators

Outpatient Parenteral Antibiotic Treatment for Infective Endocarditis: A Prospective Cohort Study From the GAMES Cohort.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2019; 69(10); 1690-1700

Robles-Vera I, Callejo M, Ramos R, Duarte J, Perez-Vizcaino F

Impact of Vitamin D Deficit on the Rat Gut Microbiome.

Nutrients, 2019; 11(11);

Fernández-Santiago R, Martín-Flores N, Antonelli F, Cerquera C, Moreno V, Bandres-Ciga S, Manduchi E, Tolosa E, Singleton AB, Moore JH, International Parkinson's Disease Genomics Consortium, Martí MJ, Ezquerra M, Malagelada C

SNCA and mTOR Pathway Single Nucleotide Polymorphisms Interact to Modulate the Age at Onset of Parkinson's Disease.

Movement disorders : official journal of the Movement Disorder Society, 2019; 34(9); 1333-1344

Toral M, Robles-Vera I, de la Visitación N, Romero M, Sánchez M, Gómez-Guzmán M, Rodriguez-Nogales A, Yang T, Jiménez R, Algieri F, Gálvez J, Raizada MK, Duarte J

Role of the immune system in vascular function and blood pressure control induced by faecal microbiota transplantation in rats.

Acta physiologica (Oxford, England), 2019; 227(1); e13285

Toral M, Robles-Vera I, Romero M, de la Visitación N, Sánchez M, O'Valle F, Rodriguez-Nogales A, Gálvez J, Duarte J, Jiménez R

Lactobacillus fermentum CECT5716: a novel alternative for the prevention of vascular disorders in a mouse model of systemic lupus erythematosus.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2019; 33(9); 10005-10018

Vazquez A, Sanchez-Rodriguez E, Vargas F, Montoro-Molina S, Romero M, Espejo-Calvo JA, Vilchez P, Jaramillo S, Olmo-García L, Carrasco-Pancorbo A, de la Torre R, Fito M, Covas MI, Martínez de Victoria E, Mesa MD

Cardioprotective Effect of a Virgin Olive Oil Enriched with Bioactive Compounds in Spontaneously Hypertensive Rats.

Nutrients, 2019; 11(8);

García-Álvarez L, Sanz MM, Marín M, Fariñas MC, Montejo M, Goikoetxea J, Rodríguez García R, de Alarcón A, Almela M, Fernández-Hidalgo N, Alonso Socas MM, Goenaga MA, Navas E, Vicioso L, Oteo JA, Spanish Collaboration on Endocarditis-Grupo de Apoyo al Manejo de la Endocarditis Infecciosa en España (GAMES)

Antimicrobial management of Tropheryma whipplei endocarditis: the Spanish Collaboration on Endocarditis (GAMES) experience.

The Journal of antimicrobial chemotherapy, 2019; 74(6); 1713-1717

Armiñanzas C, Fariñas-Alvarez C, Zarauza J, Muñoz P, González Ramallo V, Martínez Sellés M, Miró Meda JM, Pericás JM, Goenaga MÁ, Ojeda Burgos G, Rodríguez Álvarez R, Castelo Corral L, Gálvez-Acebal J, Martínez Marcos FJ, Fariñas MC, Spanish Collaboration on Endocarditis — Grupo de Apoyo al Manejo de la Endocarditis Infecciosa en Espana Study Group, Fernández Sánchez F, Noureddine M, Rosas G, de la Torre Lima J, Aramendi J, Bereciartua E, Blanco MJ, Blanco R, Boado MV, Campaña Lázaro M, Crespo A, Goikoetxea J, Iruretagoyena JR, Irurzun Zuazabal J, López-Soria L, Montejo M, Nieto J, Rodrigo D, Rodríguez D, Rodríguez R, Vitoria Y, Voces R, García López MV, Georgieva RI, Ojeda G, Rodríguez Bailón I, Ruiz Morales J, Cuende AM, Echeverría T, Fuerte A, Gaminde E, Goenaga MÁ, Idígoras P, Iribarren JA, Izaguirre Yarza A, Kortajarena Urkola X, Reviejo C, Carrasco R, Climent V, Llamas P, Merino E, Plazas J, Reus S, Álvarez N, Bravo-Ferrer JM, Castelo L, Cuenca J, Llinares P, Miguez Rey E, Rodríguez Mayo M, Sánchez E, Sousa Regueiro D, Martínez FJ, Alonso MDM, Castro B, García Rosado D, Durán MDC, Miguel Gómez MA, Lacalzada J, Nassar I, Plata Ciezar A, Reguera Iglesias JM, Asensi Álvarez V, Costas C, de la Hera J, Fernández Suárez J, Iglesias Fraile L, León Arguero V, López Menéndez J, Mencia Bajo P, Morales C, Moreno Torrico A, Palomo C, Paya Martínez B, Rodríguez Esteban Á, Rodríguez García R, Telenti Asensio M, Almela M, Ambrosioni J, Azqueta M, Brunet M, Bodro M, Cartañá R, Falces C, Fita G, Fuster D, García de la Mària C, Hernández-Meneses M, Llopis Pérez J, Marco F, Miró JM, Moreno A, Nicolás D, Ninot S, Quintana E, Paré C, Pereda D, Pericás JM, Pomar JL, Ramírez J, Rovira I, Sandoval E, Sitges M, Soy D, Téllez A, Tolosana JM, Vidal B, Vila J, Adán I, Bermejo J, Bouza E, Celemín D, Cuerpo Caballero G, Delgado Montero A, Fernández Cruz A, García Mansilla A, García Leoni ME, González Ramallo V, Kestler Hernández M, Hualde AM, Marín M, Martínez-Sellés M, Menárguez MC, Muñoz P, Rincón C, Rodríguez-Abella H, Rodríguez-Créixems M, Pinilla B, Pinto Á, Valerio M, Vázquez P, Verde Moreno E, Antorrena I, Loeches B, Martín Quirós A, Moreno M, Ramírez U, Rial Bastón V, Romero M, Saldaña A, Agüero Balbín J, Amado C, Armiñanzas Castillo C, Arnaiz García A, Cobo Belaustegui M, Fariñas MC, Fariñas-Álvarez C, Gómez Izquierdo R, García I, González-Rico C, Gutiérrez-Cuadra M, Gutiérrez Díez J, Pajarón M, Parra JA, Sarralde A, Teira R, Zarauza J, Domínguez F, García Pavía P, González J, Orden B, Ramos A, Centella T, Hermida JM, Moya JL, Martín-Dávila P, Navas E, Oliva E, Del Río A, Ruiz S, Hidalgo Tenorio C, Almendro Delia M, Araji O, Barquero JM, Calvo Jambrina R, de Cueto M, Gálvez Acebal J, Méndez I, Morales I, López-Cortés LE, de Alarcón A, García E, Haro JL, Lepe JA, López F, Luque R, Alonso LJ, Azcárate P, Azcona Gutiérrez JM, Blanco JR, García-Álvarez L, Oteo JA, Sanz M, de Benito N, Gurguí M, Pacho C, Pericas R, Pons G, Álvarez M, Fernández AL, Martínez A, Prieto A, Regueiro B, Tijeira E, Vega M, Canut Blasco A, Cordo Mollar J, Gainzarain Arana JC, García Uriarte O, Martín López A, Ortiz de Zárate Z, Urturi Matos JA, García Domínguez G, Sánchez-Porto A, Arribas Leal JM, García Vázquez E, Hernández Torres A, Blázquez A, de la Morena Valenzuela G, Alonso Á, Aramburu J, Calvo FE, Moreno Rodríguez A, Tarabini-Castellani P, Heredero Gálvez E, Maicas Bellido C, Largo Pau J, Sepúlveda MA, Toledano Sierra P, Iqbal-Mirza SZ, Cascales Alcolea E, Egea Serrano P, Hernández Roca JJ, Keituqwa Yañez I, Peláez Ballesta A, Soriano V, Moreno Escobar E, Peña Monje A, Sánchez Cabrera V, Vinuesa García D, Arrizabalaga Asenjo M, Cifuentes Luna C, Núñez Morcillo J, Pérez Seco MC, Villoslada Gelabert A, Aured Guallar C, Fernández Abad N, García Mangas P, Matamala Adell M, Palacián Ruiz MP, Porres JC, Alcaraz Vidal B, Cobos Trigueros N, Del Amor Espín MJ, Giner Caro JA, Jiménez Sánchez R, Jimeno Almazán A, Ortín Freire A, Viqueira González M, Pericás Ramis P, Ribas B

Role of age and comorbidities in mortality of patients with infective endocarditis.

European journal of internal medicine, 2019; 64; 63-71

Hidalgo-Gutiérrez A, Barriocanal-Casado E, Bakkali M, Díaz-Casado ME, Sánchez-Maldonado L, Romero M, Sayed RK, Prehn C, Escames G, Duarte J, Acuña-Castroviejo D, López LC

mice.

EMBO molecular medicine, 2019; 11(1);

Sánchez M, Romero M, Gómez-Guzmán M, Tamargo J, Pérez-Vizcaino F, Duarte J

Cardiovascular Effects of Flavonoids.

Current medicinal chemistry, 2019; 26(39); 6991-7034

Toral M, Robles-Vera I, de la Visitación N, Romero M, Yang T, Sánchez M, Gómez-Guzmán M, Jiménez R, Raizada MK, Duarte J

Critical Role of the Interaction Gut Microbiota - Sympathetic Nervous System in the Regulation of Blood Pressure.

Frontiers in physiology, 2019; 10; 231

Robles-Vera I, Toral M, de la Visitación N, Sánchez M, Romero M, Olivares M, Jiménez R, Duarte J

The Probiotic Lactobacillus fermentum Prevents Dysbiosis and Vascular Oxidative Stress in Rats with Hypertension Induced by Chronic Nitric Oxide Blockade.

Molecular nutrition & food research, 2018; 62(19); e1800298

Gómez-Guzmán M, Rodríguez-Nogales A, Algieri F, Gálvez J

Potential Role of Seaweed Polyphenols in Cardiovascular-Associated Disorders.

Marine drugs, 2018; 16(8);

Callejo M, Mondejar-Parreño G, Barreira B, Izquierdo-Garcia JL, Morales-Cano D, Esquivel-Ruiz S, Moreno L, Cogolludo Á, Duarte J, Perez-Vizcaino F

Pulmonary Arterial Hypertension Affects the Rat Gut Microbiome.

Scientific reports, 2018; 8(1); 9681

Toral M, Romero M, Rodríguez-Nogales A, Jiménez R, Robles-Vera I, Algieri F, Chueca-Porcuna N, Sánchez M, de la Visitación N, Olivares M, García F, Pérez-Vizcaíno F, Gálvez J, Duarte J

Lactobacillus fermentum Improves Tacrolimus-Induced Hypertension by Restoring Vascular Redox State and Improving eNOS Coupling.

Molecular nutrition & food research, 2018; ; e1800033

Sangrós FJ, Torrecilla J, Giráldez-García C, Carrillo L, Mancera J, Mur T, Franch J, Díez J, Goday A, Serrano R, García-Soidán FJ, Cuatrecasas G, Igual D, Moreno A, Millaruelo JM, Carramiñana F, Ruiz MA, Pérez FC, Iriarte Y, Lorenzo Á, González M, Álvarez B, Barutell L, Mayayo MS, Del Castillo M, Navarro E, Malo F, Cambra A, López R, Gutiérrez MÁ, Gutiérrez L, Boente C, Mediavilla JJ, Prieto L, Mendo L, Mansilla MJ, Ortega FJ, Borras A, Sánchez LG, Obaya JC, Alonso M, García F, Gutiérrez ÁT, Hernández AM, Suárez D, Álvarez JC, Sáenz I, Martínez FJ, Casorrán A, Ripoll J, Salanova A, Marín MT, Gutiérrez F, Innerárity J, Álvarez MDM, Artola S, Bedoya MJ, Poveda S, Álvarez F, Brito MJ, Iglesias R, Paniagua F, Nogales P, Gómez Á, Rubio JF, Durán MC, Sagredo J, Gijón MT, Rollán MÁ, Pérez PP, Gamarra J, Carbonell F, García-Giralda L, Antón JJ, de la Flor M, Martínez R, Pardo JL, Ruiz A, Plana R, Macía R, Villaró M, Babace C, Torres JL, Blanco C, Jurado Á, Martín JL, Navarro J, Sanz G, Colas R, Cordero B, de Castro C, Ibáñez M, Monzón A, Porta N, Gómez MDC, Llanes R, Rodríguez JJ, Granero E, Sánchez M, Martínez J, Ezkurra P, Ávila L, de la Sen C, Rodríguez A, Buil P, Gabriel P, Roura P, Tarragó E, Mundet X, Bosch R, González JC, Bobé MI, Mata M, Ruiz I, López F, Birules M, Armengol O, de Miguel RM, Romera L, Benito B, Piulats N, Bilbeny B, Cabré JJ, Cos X, Pujol R, Seguí M, Losada C, de Santiago AM, Muñoz P, Regidor E

Association of General and Abdominal Obesity With Hypertension, Dyslipidemia and Prediabetes in the PREDAPS Study.

Revista espanola de cardiologia (English ed.), 2018; 71(3); 170-177

Recoquillon S, Gómez-Guzmán M, Rodier M, Koffi C, Nitiéma M, Gagnadoux F, Martínez MC, Andriantsitohaina R

Non-muscular myosin light chain kinase triggers intermittent hypoxia-induced interleukin-6 release, endothelial dysfunction and permeability.

Scientific reports, 2017; 7(1); 13664

Mahmoud AM, Wilkinson FL, McCarthy EM, Moreno-Martinez D, Langford-Smith A, Romero M, Duarte J, Alexander MY

Akt/eNOS signaling and reduced oxidative stress.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2017; 31(10); 4636-4648

Díaz-de-Cerio E, Rodríguez-Nogales A, Algieri F, Romero M, Verardo V, Segura-Carretero A, Duarte J, Galvez J

The hypoglycemic effects of guava leaf (Psidium guajava L.) extract are associated with improving endothelial dysfunction in mice with diet-induced obesity.

Food research international (Ottawa, Ont.), 2017; 96; 64-71

Romero M, Toral M, Robles-Vera I, Sánchez M, Jiménez R, O'Valle F, Rodriguez-Nogales A, Pérez-Vizcaino F, Gálvez J, Duarte J

Activation of Peroxisome Proliferator Activator Receptor β/δ Improves Endothelial Dysfunction and Protects Kidney in Murine Lupus.

Hypertension (Dallas, Tex. : 1979), 2017; 69(4); 641-650

Quesada A, Segarra AB, Montoro-Molina S, de Gracia MD, Osuna A, O'Valle F, Gómez-Guzmán M, Vargas F, Wangensteen R

Glutamyl aminopeptidase in microvesicular and exosomal fractions of urine is related with renal dysfunction in cisplatin-treated rats.

PloS one, 2017; 12(4); e0175462

Luna-Sánchez M, Hidalgo-Gutiérrez A, Hildebrandt TM, Chaves-Serrano J, Barriocanal-Casado E, Santos-Fandila Á, Romero M, Sayed RK, Duarte J, Prokisch H, Schuelke M, Distelmaier F, Escames G, Acuña-Castroviejo D, López LC

CoQ deficiency causes disruption of mitochondrial sulfide oxidation, a new pathomechanism associated with this syndrome.

EMBO molecular medicine, 2017; 9(1); 78-95

Mahmoud AM, Wilkinson FL, Jones AM, Wilkinson JA, Romero M, Duarte J, Alexander MY

A novel role for small molecule glycomimetics in the protection against lipid-induced endothelial dysfunction: Involvement of Akt/eNOS and Nrf2/ARE signaling.

Biochimica et biophysica acta. General subjects, 2017; 1861(1 Pt A); 3311-3322

Morales-Cano D, Moreno L, Barreira B, Briones AM, Pandolfi R, Moral-Sanz J, Callejo M, Mondejar-Parreño G, Cortijo J, Salaices M, Duarte J, Perez-Vizcaino F, Cogolludo A

Activation of PPARβ/δ prevents hyperglycaemia-induced impairment of Kv7 channels and cAMP-mediated relaxation in rat coronary arteries.

Clinical science (London, England : 1979), 2016; 130(20); 1823-36

Toral M, Romero M, Jiménez R, Robles-Vera I, Tamargo J, Martínez MC, Pérez-Vizcaíno F, Duarte J

Role of UCP2 in the protective effects of PPARβ/δ activation on lipopolysaccharide-induced endothelial dysfunction.

Biochemical pharmacology, 2016; 110-111; 25-36

Romero M, Leon-Gomez E, Lobysheva I, Rath G, Dogné JM, Feron O, Dessy C

Effects of BM-573 on Endothelial Dependent Relaxation and Increased Blood Pressure at Early Stages of Atherosclerosis.

PloS one, 2016; 11(3); e0152579

Romero M, Toral M, Gómez-Guzmán M, Jiménez R, Galindo P, Sánchez M, Olivares M, Gálvez J, Duarte J

Antihypertensive effects of oleuropein-enriched olive leaf extract in spontaneously hypertensive rats.

Food & function, 2016; 7(1); 584-93

Toral M, Romero M, Jiménez R, Mahmoud AM, Barroso E, Gómez-Guzmán M, Sánchez M, Cogolludo Á, García-Redondo AB, Briones AM, Vázquez-Carrera M, Pérez-Vizcaíno F, Duarte J

Carnitine palmitoyltransferase-1 up-regulation by PPAR-β/δ prevents lipid-induced endothelial dysfunction.

Clinical science (London, England : 1979), 2015; 129(9); 823-37

Gómez-Guzmán M, Toral M, Romero M, Jiménez R, Galindo P, Sánchez M, Zarzuelo MJ, Olivares M, Gálvez J, Duarte J

Antihypertensive effects of probiotics Lactobacillus strains in spontaneously hypertensive rats.

Molecular nutrition & food research, 2015; 59(11); 2326-36

Toral M, Gómez-Guzmán M, Jiménez R, Romero M, Zarzuelo MJ, Utrilla MP, Hermenegildo C, Cogolludo Á, Pérez-Vizcaíno F, Gálvez J, Duarte J

Chronic peroxisome proliferator-activated receptorβ/δ agonist GW0742 prevents hypertension, vascular inflammatory and oxidative status, and endothelial dysfunction in diet-induced obesity.

Journal of hypertension, 2015; 33(9); 1831-44

Morales-Cano D, Moreno L, Barreira B, Pandolfi R, Chamorro V, Jimenez R, Villamor E, Duarte J, Perez-Vizcaino F, Cogolludo A

Kv7 channels critically determine coronary artery reactivity: left-right differences and down-regulation by hyperglycaemia.

Cardiovascular research, 2015; 106(1); 98-108

Jimenez R, Lopez-Sepulveda R, Romero M, Toral M, Cogolludo A, Perez-Vizcaino F, Duarte J

Quercetin and its metabolites inhibit the membrane NADPH oxidase activity in vascular smooth muscle cells from normotensive and spontaneously hypertensive rats.

Food & function, 2015; 6(2); 409-14

Tamargo J, Duarte J, Ruilope LM

New antihypertensive drugs under development.

Current medicinal chemistry, 2015; 22(3); 305-42

López-Farré AJ, Rodriguez-Sierra P, Modrego J, Segura A, Martín-Palacios N, Saiz AM, Zamorano-León JJ, Duarte J, Serrano J, Moñux G

Effects of factor Xa on the expression of proteins in femoral arteries from type 2 diabetic patients.

British journal of clinical pharmacology, 2014; 78(6); 1366-77

Perez A, Gonzalez-Manzano S, Jimenez R, Perez-Abud R, Haro JM, Osuna A, Santos-Buelga C, Duarte J, Perez-Vizcaino F

The flavonoid quercetin induces acute vasodilator effects in healthy volunteers: correlation with beta-glucuronidase activity.

Pharmacological research, 2014; 89; 11-8

Duarte J, Francisco V, Perez-Vizcaino F

Modulation of nitric oxide by flavonoids.

Food & function, 2014; 5(8); 1653-68

Gómez-Guzmán M, Jiménez R, Romero M, Sánchez M, Zarzuelo MJ, Gómez-Morales M, O'Valle F, López-Farré AJ, Algieri F, Gálvez J, Pérez-Vizcaino F, Sabio JM, Duarte J

Chronic hydroxychloroquine improves endothelial dysfunction and protects kidney in a mouse model of systemic lupus erythematosus.

Hypertension, 2014; 64(2); 330-7

Toral M, Gómez-Guzmán M, Jiménez R, Romero M, Sánchez M, Utrilla MP, Garrido-Mesa N, Rodríguez-Cabezas ME, Olivares M, Gálvez J, Duarte J

The probiotic Lactobacillus coryniformis CECT5711 reduces the vascular pro-oxidant and pro-inflammatory status in obese mice.

Clinical science (London, England : 1979), 2014; 127(1); 33-45

Quintela AM, Jiménez R, Piqueras L, Gómez-Guzmán M, Haro J, Zarzuelo MJ, Cogolludo A, Sanz MJ, Toral M, Romero M, Pérez-Vizcaíno F, Duarte J

PPARβ activation restores the high glucose-induced impairment of insulin signalling in endothelial cells.

British journal of pharmacology, 2014; 171(12); 3089-102

Montiel V, Leon Gomez E, Bouzin C, Esfahani H, Romero Perez M, Lobysheva I, Devuyst O, Dessy C, Balligand JL

Genetic deletion of aquaporin-1 results in microcardia and low blood pressure in mouse with intact nitric oxide-dependent relaxation, but enhanced prostanoids-dependent relaxation.

Pflügers Archiv : European journal of physiology, 2014; 466(2); 237-51

Morales-Cano D, Menendez C, Moreno E, Moral-Sanz J, Barreira B, Galindo P, Pandolfi R, Jimenez R, Moreno L, Cogolludo A, Duarte J, Perez-Vizcaino F

The flavonoid quercetin reverses pulmonary hypertension in rats.

PloS one, 2014; 9(12); e114492

Zarzuelo MJ, Gómez-Guzmán M, Jiménez R, Quintela AM, Romero M, Sánchez M, Zarzuelo A, Tamargo J, Pérez-Vizcaíno F, Duarte J

Effects of peroxisome proliferator-activated receptor-β activation in endothelin-dependent hypertension.

Cardiovascular research, 2013; 99(4); 622-31

Zarzuelo MJ, López-Sepúlveda R, Sánchez M, Romero M, Gómez-Guzmán M, Ungvary Z, Pérez-Vizcaíno F, Jiménez R, Duarte J

SIRT1 inhibits NADPH oxidase activation and protects endothelial function in the rat aorta: implications for vascular aging.

Biochemical pharmacology, 2013; 85(9); 1288-96

Jiménez R, Duarte J, Perez-Vizcaino F

Epicatechin: endothelial function and blood pressure.

Journal of agricultural and food chemistry, 2012; 60(36); 8823-30

Rath G, Saliez J, Behets G, Romero-Perez M, Leon-Gomez E, Bouzin C, Vriens J, Nilius B, Feron O, Dessy C

Vascular hypoxic preconditioning relies on TRPV4-dependent calcium influx and proper intercellular gap junctions communication.

Arteriosclerosis, thrombosis, and vascular biology, 2012; 32(9); 2241-9

Quintela AM, Jiménez R, Gómez-Guzmán M, Zarzuelo MJ, Galindo P, Sánchez M, Vargas F, Cogolludo A, Tamargo J, Pérez-Vizcaíno F, Duarte J

Activation of peroxisome proliferator-activated receptor-β/-δ (PPARβ/δ) prevents endothelial dysfunction in type 1 diabetic rats.

Free radical biology & medicine, 2012; 53(4); 730-41

Li Y, Wang H, Tarus B, Perez MR, Morellato L, Henry E, Berka V, Tsai AL, Ramassamy B, Dhimane H, Dessy C, Tauc P, Boucher JL, Deprez E, Slama-Schwok A

Rational design of a fluorescent NADPH derivative imaging constitutive nitric-oxide synthases upon two-photon excitation.

Proceedings of the National Academy of Sciences of the United States of America, 2012; 109(31); 12526-31

Perez-Vizcaino F, Duarte J, Santos-Buelga C

The flavonoid paradox: conjugation and deconjugation as key steps for the biological activity of flavonoids.

Journal of the science of food and agriculture, 2012; 92(9); 1822-5

Galindo P, González-Manzano S, Zarzuelo MJ, Gómez-Guzmán M, Quintela AM, González-Paramás A, Santos-Buelga C, Pérez-Vizcaíno F, Duarte J, Jiménez R

Different cardiovascular protective effects of quercetin administered orally or intraperitoneally in spontaneously hypertensive rats.

Food & function, 2012; 3(6); 643-50

Galindo P, Rodriguez-Gómez I, González-Manzano S, Dueñas M, Jiménez R, Menéndez C, Vargas F, Tamargo J, Santos-Buelga C, Pérez-Vizcaíno F, Duarte J

Glucuronidated quercetin lowers blood pressure in spontaneously hypertensive rats via deconjugation.

PloS one, 2012; 7(3); e32673

Gómez-Guzmán M, Jiménez R, Sánchez M, Zarzuelo MJ, Galindo P, Quintela AM, López-Sepúlveda R, Romero M, Tamargo J, Vargas F, Pérez-Vizcaíno F, Duarte J

Epicatechin lowers blood pressure, restores endothelial function, and decreases oxidative stress and endothelin-1 and NADPH oxidase activity in DOCA-salt hypertension.

Free radical biology & medicine, 2012; 52(1); 70-9

Menendez C, Dueñas M, Galindo P, González-Manzano S, Jimenez R, Moreno L, Zarzuelo MJ, Rodríguez-Gómez I, Duarte J, Santos-Buelga C, Perez-Vizcaino F

Vascular deconjugation of quercetin glucuronide: the flavonoid paradox revealed?

Molecular nutrition & food research, 2011; 55(12); 1780-90

Gómez-Guzmán M, Jiménez R, Sánchez M, Romero M, O'Valle F, Lopez-Sepulveda R, Quintela AM, Galindo P, Zarzuelo MJ, Bailón E, Delpón E, Perez-Vizcaino F, Duarte J

Chronic (-)-epicatechin improves vascular oxidative and inflammatory status but not hypertension in chronic nitric oxide-deficient rats.

The British journal of nutrition, 2011; 106(9); 1337-48

Zarzuelo MJ, Jiménez R, Galindo P, Sánchez M, Nieto A, Romero M, Quintela AM, López-Sepúlveda R, Gómez-Guzmán M, Bailón E, Rodríguez-Gómez I, Zarzuelo A, Gálvez J, Tamargo J, Pérez-Vizcaíno F, Duarte J

Antihypertensive effects of peroxisome proliferator-activated receptor-β activation in spontaneously hypertensive rats.

Hypertension, 2011; 58(4); 733-43

Menendez C, Jimenez R, Moreno L, Galindo P, Cogolludo A, Duarte J, Perez-Vizcaino F

Lack of synergistic interaction between quercetin and catechin in systemic and pulmonary vascular smooth muscle.

The British journal of nutrition, 2011; 105(9); 1287-93

López-Sepúlveda R, Gómez-Guzmán M, Zarzuelo MJ, Romero M, Sánchez M, Quintela AM, Galindo P, O'Valle F, Tamargo J, Pérez-Vizcaíno F, Duarte J, Jiménez R

Red wine polyphenols prevent endothelial dysfunction induced by endothelin-1 in rat aorta: role of NADPH oxidase.

Clinical science (London, England : 1979), 2011; 120(8); 321-33

Ungvari Z, Bailey-Downs L, Gautam T, Jimenez R, Losonczy G, Zhang C, Ballabh P, Recchia FA, Wilkerson DC, Sonntag WE, Pearson K, de Cabo R, Csiszar A

Adaptive induction of NF-E2-related factor-2-driven antioxidant genes in endothelial cells in response to hyperglycemia.

American journal of physiology. Heart and circulatory physiology, 2011; 300(4); H1133-40

Perez-Vizcaino F, Duarte J

Flavonols and cardiovascular disease.

Molecular aspects of medicine, 2010; 31(6); 478-94

Romero M, Jiménez R, Sánchez M, López-Sepúlveda R, Zarzuelo A, Tamargo J, Pérez-Vizcaíno F, Duarte J

Vascular superoxide production by endothelin-1 requires Src non-receptor protein tyrosine kinase and MAPK activation.

Atherosclerosis, 2010; 212(1); 78-85

Caballero R, Dolz-Gaitón P, Gómez R, Amorós I, Barana A, González de la Fuente M, Osuna L, Duarte J, López-Izquierdo A, Moraleda I, Gálvez E, Sánchez-Chapula JA, Tamargo J, Delpón E

Flecainide increases Kir2.1 currents by interacting with cysteine 311, decreasing the polyamine-induced rectification.

Proceedings of the National Academy of Sciences of the United States of America, 2010; 107(35); 15631-6

Jiménez R, Sánchez M, Zarzuelo MJ, Romero M, Quintela AM, López-Sepúlveda R, Galindo P, Gómez-Guzmán M, Haro JM, Zarzuelo A, Pérez-Vizcaíno F, Duarte J

Endothelium-dependent vasodilator effects of peroxisome proliferator-activated receptor beta agonists via the phosphatidyl-inositol-3 kinase-Akt pathway.

The Journal of pharmacology and experimental therapeutics, 2010; 332(2); 554-61

Csiszar A, Labinskyy N, Jimenez R, Pinto JT, Ballabh P, Losonczy G, Pearson KJ, de Cabo R, Ungvari Z

Anti-oxidative and anti-inflammatory vasoprotective effects of caloric restriction in aging: role of circulating factors and SIRT1.

Mechanisms of ageing and development, 2009; 130(8); 518-27

Lodi F, Jimenez R, Moreno L, Kroon PA, Needs PW, Hughes DA, Santos-Buelga C, Gonzalez-Paramas A, Cogolludo A, Lopez-Sepulveda R, Duarte J, Perez-Vizcaino F

Glucuronidated and sulfated metabolites of the flavonoid quercetin prevent endothelial dysfunction but lack direct vasorelaxant effects in rat aorta.

Atherosclerosis, 2009; 204(1); 34-9

Romero M, Jiménez R, Sánchez M, López-Sepúlveda R, Zarzuelo MJ, O'Valle F, Zarzuelo A, Pérez-Vizcaíno F, Duarte J

Quercetin inhibits vascular superoxide production induced by endothelin-1: Role of NADPH oxidase, uncoupled eNOS and PKC.

Atherosclerosis, 2009; 202(1); 58-67

López-Sepúlveda R, Jiménez R, Romero M, Zarzuelo MJ, Sánchez M, Gómez-Guzmán M, Vargas F, O'Valle F, Zarzuelo A, Pérez-Vizcaíno F, Duarte J

Wine polyphenols improve endothelial function in large vessels of female spontaneously hypertensive rats.

Hypertension, 2008; 51(4); 1088-95

Galisteo M, Duarte J, Zarzuelo A

Effects of dietary fibers on disturbances clustered in the metabolic syndrome.

The Journal of nutritional biochemistry, 2008; 19(2); 71-84

Vera R, Jiménez R, Lodi F, Sánchez M, Galisteo M, Zarzuelo A, Pérez-Vizcaíno F, Duarte J

Genistein restores caveolin-1 and AT-1 receptor expression and vascular function in large vessels of ovariectomized hypertensive rats.

Menopause (New York, N.Y.), 2007; 14(5); 933-40

Jiménez R, López-Sepúlveda R, Kadmiri M, Romero M, Vera R, Sánchez M, Vargas F, O'Valle F, Zarzuelo A, Dueñas M, Santos-Buelga C, Duarte J

Polyphenols restore endothelial function in DOCA-salt hypertension: role of endothelin-1 and NADPH oxidase.

Free radical biology & medicine, 2007; 43(3); 462-73

Sanchez M, Lodi F, Vera R, Villar IC, Cogolludo A, Jimenez R, Moreno L, Romero M, Tamargo J, Perez-Vizcaino F, Duarte J

Quercetin and isorhamnetin prevent endothelial dysfunction, superoxide production, and overexpression of p47phox induced by angiotensin II in rat aorta.

The Journal of nutrition, 2007; 137(4); 910-5

Vera R, Sánchez M, Galisteo M, Villar IC, Jimenez R, Zarzuelo A, Pérez-Vizcaíno F, Duarte J

Chronic administration of genistein improves endothelial dysfunction in spontaneously hypertensive rats: involvement of eNOS, caveolin and calmodulin expression and NADPH oxidase activity.

Clinical science (London, England : 1979), 2007; 112(3); 183-91

Título del proyecto: Participación de la microbiota intestinal en el efecto antihipertensivo de la fibra dietética en hipertensión genética. difimigen

Financiador: UNIVERSIDAD DE GRANADA

Nº Expediente: B-CTS-046-UGR18

Ejecución: 2020-2021

IP: MIGUEL ROMERO PEREZ

Título del proyecto: Mecanismos gene´ticos de los efectos vasculares, renales y metabo´licos de los agonistas de receptores activados por proliferador de peroxisomas (PPAR)-beta/delta en el lupus eritematoso siste´mico

Financiador: CONSEJERIA DE ECONOMIA, INNOVACION, CIENCIA Y EMPLEO

Nº Expediente: IBS-P12-CTS-2722

Ejecución: 2014-2017

IP: JUAN MANUEL DUARTE

Título del proyecto: EFECTOS CARDIOVASCULARES DE AGONISTAS DE LOS RECEPTORES ACTIVADOS POR PROLIFERADOR DE PEROXISOMAS (PPAR)?/? EN MODELOS DE DIABETES EXPERIMENTAL

Financiador: MINISTERIO DE ECONOMIA Y COMPETITIVIDAD

Nº Expediente: IBS-SAF2010-22066-C02-01

Ejecución: 2011-2013

IP: JUAN MANUEL DUARTE

Título del proyecto: BIODISPONIBILIDAD Y EFECTO ANTIHIPERTENSIVO DE QUERCETINA

Financiador: MINISTERIO DE ECONOMIA Y COMPETITIVIDAD

Nº Expediente: IBS-AGL2007-66108-C04-03/ALI

Ejecución: 2007-2010

IP: ROSARIO JIMÉNEZ

Título del proyecto: PAPEL DE LOS RECEPTORES ACTIVADOS POR PROLIFERADOR DE PEROXISOMAS (PPAR)BETA/DELTA EN EL CONTROL DE LA FUNCION VASCULAR Y DE LA HIPERTENSION ARTERIAL

Financiador: MINISTERIO DE ECONOMIA Y COMPETITIVIDAD

Nº Expediente: IBS-SAF2007-62731

Ejecución: 2007-2010

IP: JUAN MANUEL DUARTE

Título del proyecto: DETERMINANTES GENÉTICOS Y AMBIENTALES DE LA DISFUNCIÓN VASCULAR EN LA HIPERTENSIÓN Y EN LA CARDIOPATÍA ISQUÉMICA: RED HERACLES

Financiador: Instituto de Salud Carlos III

Nº Expediente: IBS-RD06/0009/0006

Ejecución: 2007-2012

IP: JUAN MANUEL DUARTE

Título del proyecto: POLIFENOLES DE LA DIETA: FUNCIÓN ENDOTELIAL, INFLAMACIÓN VASCULAR Y ANGIOGÉNESIS

Financiador: CONSEJERIA DE ECONOMIA, INNOVACION, CIENCIA Y EMPLEO

Nº Expediente: IBS-P06-CTS-01555

Ejecución: 2007-2010

IP: JUAN MANUEL DUARTE