NIR-NanoCAR – Near-Infrared Photothermal Nano-CAR Immunotherapy mediated by engineered exosomes targeted to pancreatic cancer with mutated KRAS
In NIR-NanoCAR project, we will develop a new concept of therapy, Near-Infrared (NIR) Photothermal Nano-CAR Immunotherapy (NIR-PNCI). To test this concept, we will fuse i) thermosensitive liposomes capable to mediate photothermal therapy by NIR, with ii) exosomes derived from mesothelin-CAR T cells armored with IL-12 (which maintain effector molecules from their parental cells) and loaded with siRNA targeted to mutated KRAS. We will explore the antitumor capability and the tumor microenvironment-reprograming mediated by the hybrid nanotherapy in a relevant murine PDAC model.
- Funder: European Commission
- Project ID: 101110299
- Researcher: José Carlos Prados Salazar
- Group: A01-TECNOLOGIA APLICADA A ONCOLOGIA Y TERAPIA GENICA
- Center: University of Granada
- Rol in the project: Coordinator
- Duration: 2024 – 2025