Polimorfismo en artritis reumatoide. Expresión génica en enfermedades autoinmunes. Factores de respuesta a las terapias biológicas. Factores pronóstico de evolución y respuesta. Riesgo cardiovascular en enfermedades autoinmunes. Factores reumaotoides en la etiopalogenia de la artritis reumatoide.
Lineas de investigación
Aplicación de Transcriptomica en enfermedades reumatológicas.
Asociación de polimorfismos de un SNPS de los genes de las vias de señalización intracelular NFKB, MAPK y JA con la artritis reumatoide (AR)
Bases farmacogenéticas de la eficacia y toxicidad de los fármacos en la artritis reumatoide.
Diferentes perfiles de expresión génica en la Espondilitis anquilosante.
Estudio de las bases moleculares de la susceptibilidad y/o progresión de la artritis reumatoide. Marcadores genéticos de susceptibilidad y/o progresión de la artritis reumatoide
Estudio de los factores pronósticos de enfermedad grave en la Artritis Reumatoide de reciente comienzo.
Palabras clave
Artritis Reumatoide, Expresión Genética, Marcadores De Respuesta, Riesgo Cardiovascular.
López-Rodríguez R, Ferreiro-Iglesias A, Lima A, Bernardes M, Pawlik A, Paradowska-Gorycka A, Świerkot J, Slezak R, Dolžan V, González-Álvaro I, Narváez J, Cáliz R, Pérez-Pampín E, Mera-Varela A, Vidal-Bralo L, Acuña Ochoa JG, Conde C, Gómez-Reino JJ, González A
Replication study of polymorphisms associated with response to methotrexate in patients with rheumatoid arthritis.
Scientific reports, 2018; 8(1); 7342
FI: 4.122; Q1 / D2
Diaz-Piedra C, Guzman MA, Buela-Casal G, Catena A
The impact of fibromyalgia symptoms on brain morphometry.
Brain imaging and behavior, 2016; 10(4); 1184-1197
FI: 3.985; Q1 / D3
Hernández-Cruz B, Márquez-Saavedra E, Caliz-Caliz R, Navarro-Sarabia F
Comparative effectiveness of treatment with the first TNF antagonist in monotherapy, the first TNF antagonist plus one conventional synthetic disease-modifying antirheumatic drug, and the first TNF antagonist plus two or more conventional synthetic disease-modifying antirheumatic drugs in patients with rheumatoid arthritis.
Arthritis research & therapy, 2016; 18(1); 259
FI: 4.121; Q1 / D3
Ferreiro-Iglesias A, Montes A, Perez-Pampin E, Cañete JD, Raya E, Magro-Checa C, Vasilopoulos Y, Sarafidou T, Caliz R, Ferrer MA, Joven B, Carreira P, Balsa A, Pascual-Salcedo D, Blanco FJ, Moreno-Ramos MJ, Fernández-Nebro A, Ordóñez MC, Alegre-Sancho JJ, Narváez J, Navarro-Sarabia F, Moreira V, Valor L, García-Portales R, Marquez A, Martin J, Gómez-Reino JJ, Gonzalez A
Replication of PTPRC as genetic biomarker of response to TNF inhibitors in patients with rheumatoid arthritis.
The pharmacogenomics journal, 2016; 16(2); 137-40
FI: 3.815; Q1 / D2
Montes A, Perez-Pampin E, Navarro-Sarabia F, Moreira V, de la Serna AR, Magallares B, Vasilopoulos Y, Sarafidou T, Fernández-Nebro A, Ordóñez Mdel C, Narváez J, Cañete JD, Marquez A, Pascual-Salcedo D, Joven B, Carreira P, Moreno-Ramos MJ, Caliz R, Ferrer MA, Garcia-Portales R, Blanco FJ, Magro C, Raya E, Valor L, Alegre-Sancho JJ, Balsa A, Martin J, Plant D, Isaacs J, Morgan AW, Barton A, Wilson AG, Biologics in Rheumatoid Arthritis Genetics and Genomics Study Syndicate (BRAGGSS), Gómez-Reino JJ, Gonzalez A
Rheumatoid arthritis response to treatment across IgG1 allotype - anti-TNF incompatibility: a case-only study.
Arthritis research & therapy, 2015; 17; 63
FI: 3.979; Q1 / D3
Cobo-Ibáñez T, Loza-Santamaría E, Pego-Reigosa JM, Marqués AO, Rúa-Figueroa I, Fernández-Nebro A, Cáliz Cáliz R, López Longo FJ, Muñoz-Fernández S
Efficacy and safety of rituximab in the treatment of non-renal systemic lupus erythematosus: a systematic review.
Seminars in arthritis and rheumatism, 2014; 44(2); 175-85
FI: 3.925; Q1 / D3
Martínez MP, Miró E, Sánchez AI, Díaz-Piedra C, Cáliz R, Vlaeyen JW, Buela-Casal G
Cognitive-behavioral therapy for insomnia and sleep hygiene in fibromyalgia: a randomized controlled trial.
Journal of behavioral medicine, 2014; 37(4); 683-97
FI: 2.959; Q1 / D2
Montes A, Perez-Pampin E, Narváez J, Cañete JD, Navarro-Sarabia F, Moreira V, Fernández-Nebro A, Del Carmen Ordóñez M, de la Serna AR, Magallares B, Vasilopoulos Y, Sarafidou T, Caliz R, Ferrer MA, Joven B, Carreira P, Gómez-Reino JJ, Gonzalez A
Association of FCGR2A with the response to infliximab treatment of patients with rheumatoid arthritis.
Pharmacogenetics and genomics, 2014; 24(5); 238-45
FI: 3.481; Q1 / D3
Cáliz R, Canet LM, Lupiañez CB, Canhão H, Escudero A, Filipescu I, Segura-Catena J, Soto-Pino MJ, Expósito-Ruiz M, Ferrer MÁ, García A, Romani L, González-Utrilla A, Vallejo T, Pérez-Pampin E, Hemminki K, Försti A, Collantes E, Fonseca JE, Sainz J
Gender-specific effects of genetic variants within Th1 and Th17 cell-mediated immune response genes on the risk of developing rheumatoid arthritis.
PloS one, 2013; 8(8); e72732
FI: 3.534; Q1 / D2
Bravo Mancheño B, Perin F, Guez Vázquez Del Rey Mdel M, García Sánchez A, Alcázar Romero PP
Successful tocilizumab treatment in a child with refractory Takayasu arteritis.
Pediatrics, 2012; 130(6); e1720-4
FI: 5.119; Q1 / D1
Rojo Venegas K, Aguilera Gómez M, Eisman JA, García Sánchez A, Faus Dader MJ, Calleja Hernández MA
Pharmacogenetics of osteoporosis-related bone fractures: moving towards the harmonization and validation of polymorphism diagnostic tools.
Pharmacogenomics, 2010; 11(9); 1287-303
FI: 3.876; Q1 / D2
Suarez-Gestal M, Calaza M, Dieguez-Gonzalez R, Perez-Pampin E, Pablos JL, Navarro F, Narvaez J, Marenco JL, Herrero-Beaumont G, Fernandez-Gutierrez B, Lamas JR, de la Serna AR, Ortiz AM, Carreño L, Cañete JD, Caliz R, Blanco FJ, Balsa A, Gomez-Reino JJ, Gonzalez A
Rheumatoid arthritis does not share most of the newly identified systemic lupus erythematosus genetic factors.
Arthritis and rheumatism, 2009; 60(9); 2558-64
FI: 7.332; Q1 / D1
Dieguez-Gonzalez R, Akar S, Calaza M, Perez-Pampin E, Costas J, Torres M, Vicario JL, Velloso ML, Navarro F, Narvaez J, Joven B, Herrero-Beaumont G, Gonzalez-Alvaro I, Fernandez-Gutierrez B, de la Serna AR, Carreño L, Lopez-Longo J, Caliz R, Collado-Escobar MD, Blanco FJ, Fernandez-Lopez C, Balsa A, Pascual-Salcedo D, Gomez-Reino JJ, Gonzalez A
Genetic variation in the nuclear factor kappaB pathway in relation to susceptibility to rheumatoid arthritis.
Annals of the rheumatic diseases, 2009; 68(4); 579-83
FI: 8.111; Q1 / D1
Dieguez-Gonzalez R, Calaza M, Perez-Pampin E, Balsa A, Blanco FJ, Cañete JD, Caliz R, Carreño L, de la Serna AR, Fernandez-Gutierrez B, Ortiz AM, Herrero-Beaumont G, Pablos JL, Narvaez J, Navarro F, Marenco JL, Gomez-Reino JJ, Gonzalez A
Analysis of TNFAIP3, a feedback inhibitor of nuclear factor-kappaB and the neighbor intergenic 6q23 region in rheumatoid arthritis susceptibility.
Arthritis research & therapy, 2009; 11(2); R42
FI: 4.271; Q1 / D3
Dieguez-Gonzalez R, Calaza M, Perez-Pampin E, de la Serna AR, Fernandez-Gutierrez B, Castañeda S, Largo R, Joven B, Narvaez J, Navarro F, Marenco JL, Vicario JL, Blanco FJ, Fernandez-Lopez JC, Caliz R, Collado-Escobar MD, Carreño L, Lopez-Longo J, Cañete JD, Gomez-Reino JJ, Gonzalez A
Association of interferon regulatory factor 5 haplotypes, similar to that found in systemic lupus erythematosus, in a large subgroup of patients with rheumatoid arthritis.
High digestive haemorrhage by oesophageal varices degree 0-1 of paquet secondary to presinuosity portal hypertension due to portal vein thrombosis with development of cavernomatosis in a young woman how first manifestation of primary antiphospholipid antibody syndrome
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, 2007; 25;
FI: 2.27; Q1 / D3
Orozco G, Sánchez E, González-Gay MA, López-Nevot MA, Torres B, Cáliz R, Ortego-Centeno N, Jiménez-Alonso J, Pascual-Salcedo D, Balsa A, de Pablo R, Nuñez-Roldan A, González-Escribano MF, Martín J
Association of a functional single-nucleotide polymorphism of PTPN22, encoding lymphoid protein phosphatase, with rheumatoid arthritis and systemic lupus erythematosus.
Arthritis Rheum, 2005; 52; 219-24
FI: 7.421; Q1 / D1
Collado L, Rueda B, Cáliz R, Torres B, García A, Nuñez-Roldan A, González-Escribano MF, Martin J
Lack of association between the I kappa BL promoter polymorphism and rheumatoid arthritis.
