TARGETOF: Mass cytometry nanotools for intracellular target engagement. Towards precision medicine

Researcher: Rosario Maria Sanchez Martin
Group: <a href="https://www.ibsgranada.es/en/grupos-de-investigacion/tece18-nanochembio/">TECe18-NANOCHEMB
Centre: University of Grenada
Role in the project: Coordinator
Duration: 2021-2023

ibs.GRANADA · International Projects

The discovery of multi-kinase inhibitors has emerged as a strong novel treatment for many human cancers. However, the severe side effects due to their intrinsic off-target action impose restrictions on their dosage and limit their efficacy. The EU-funded TARGET OF project proposes an efficient approach to detect the binding of a given drug to intracellular target proteins. The approach combines intracellular target engagement devices based on nanotechnology with state-of-the-art mass cytometry techniques, allowing one-step target engagement profiling, thus streamlining the discovery of the action profile of a given drug. This research will greatly contribute to the development of straight forward methods to detect the most expressed targets in the biopsies and select the best course of treatment for the patient.