They patent a new device, safer and cheaper, to perform anastomosis surgical operations
Anastomosis is a surgical connection between two structures, usually tubular, such as the blood vessels or the loops of the intestine
Researchers from the Biosanitary Research Institute of Granada (ibs.GRANADA), the University of Granada and the Andalusian Health Service (SAS) of the Junta de Andalucía have patented a new device to perform anastomosis operations, consisting of an artificial conduit, that will save complex surgical techniques with high costs and high morbidity.
This device is a three-dimensional tube made of biocompatible and resorbable material, preferably collagen, which works morphologically and functionally in the same way as the native canal and can be used as a substitute for it.
Anastomosis is a surgical connection between two structures, usually tubular, such as the blood vessels or the loops of the intestine. For example, when part of a intestine is surgically removed, the two remaining ends are sewn or stapled together (anastomosed) and this procedure is known as an intestinal anastomosis.
The device patented by the UGR has a plurality of pores on its surface, and is covered by a material that allows the migration of macromolecules through its interior, such as agarose hydrogel, gelatin, chitosan, hyaluronic acid , or alginate.
The device could be used in any anastomosis operation, and in particular for biliary, biliary-digestive, intestinal, pancreatic, pancreatic-digestive, gastroesophageal and colon anastomoses.
Animal experiments
As the authors of this patent explain, the University of Granada researcher Alejandro Pérez Alonso and Pablo Torne Poyatos, researcher at the ibs.GRANADA, and member of the group A-15 Basic and Clinical OncologyTo date, consistent experiments have been carried out in the implantation of devices for biliary anastomosis in experimental animals.
“The implanted tubes acquired a function and shape similar to that of the native bile duct from the fourth week after grafting. Likewise, studies are currently being carried out on the histology and immunohistology of the device, which seem to provisionally show that the tissue arrangement is histologically similar, with a similar antigenic expression ”, although these are still early results and require further study , both researchers point out.
These results reveal the possibility of new therapeutic routes for the treatment of conditions confined to the extrahepatic bile duct, avoiding complex surgical techniques with high socioeconomic costs and high morbidity.
The new patented system avoids complex surgical techniques; reduces socioeconomic costs and high morbidity; it has easy availability and reproduction and low production costs; maintaining the functionality, physiology and native morphology since its implantation.
After this important advance that the patent has entailed, scientists from Granada are currently seeking the collaboration of pharmaceutical companies and public and private organizations in the sector that wish to continue expanding this line of research.
Bibliographic reference: Reconstruction of the bile duct using three-dimensional collagen tubes Alejandro José Pérez Alonso, Carlos del Olmo Rivas, Ignacio Machado Romero, Beatriz Pérez Cabrera, Francisco Javier Cañizares García and Pablo Torné Poyatos Spanish Surgery. Volume 91, Issue 9, November 2013, Pages 590–594 DOI: http://dx.doi.org/10.1016/j.ciresp.2012.10.006
Contact:
alexander jose alonso perez
Department of Surgery and its specialties at the University of Granada. Mobile: 649639436. Email: apma85@hotmail.com
Pablo Torne Poyatos
Department of Surgery and its specialties at the University of Granada. Telephone: 958240724. Email: ptorne@ugr.es