TECE18-Nanochange
Advanced Therapies and Biomedical Technologies / IBS-TECE18 / Consolidated
The NANOCHEMBIO research group focuses on the development of therapeutic and diagnostic tools, based on nanotechnology, biomaterials and dynamic chemistry, always working in close collaboration with clinicians.
Research lines
- Development of nanosystem for CAR-T therapy
- Nano3Devices: Multifunctional nano-system with theranostic application in cancer.
Research networks
- CA21113 - Genome Editing to Treat Humans Diseases (GenE-Humdi)
- RED2022-134560-T - NANOMEDICINE NETWORK TO ADVANCE THE DIAGNOSIS AND TREATMENT OF DISEASES WITH HIGH SOCIAL IMPACT
Monica Rodriguez Segura
ISMAEL MARTOS JAMAI
MARIA DEL CARMEN ORTEGA LIEBANA
FRANCISCO JAVIER LOPEZ DELGADO
Mª ANGELICA LUQUE GONZALEZ
BETHLEHEM RUBIO RUIZ
MARIA PAZ RUIZ BLAS
ROSARIO MARIA SANCHEZ MARTIN
ARACELI AGUILAR GONZALEZ
VICTORIA CANO CORTES
JUAN JOSE DIAZ MOCHON
Title: FUNCTIONALIZED NANOPARTICLES (NPS)
Dress: EP23382751.8
Application date: 20 / 07 / 2023
Inventors: JUAN JOSÉ DÍAZ MOCHÓN
Title: DUAL-GUIDE RNA COMPOSITION FOR EXECUTING A SINGLE-GUIDE RNA CRISPR-ASSOCIATED SYSTEM
Dress: EP23382131.3
Application date: 13 / 02 / 2023
Inventors: MARÍA JOSÉ SERRANO FERNÁNDEZ, BERNARDINO ALCÁZAR NAVARRETE, PEDRO JOSÉ ROMERO, JUAN JOSÉ DÍAZ MOCHÓN, JOSÉ ANTONIO LORENTE ACOSTA, DIEGO DE MIGUEL PÉREZ
TitleISOLATION OF CIRCULATING EPITHELIAL CELLS IN PERIPHERAL BLOOD: DIAGNOSIS, PROGNOSIS
Dress: 17/513.080. USA
Application date: 28 / 10 / 2021
Inventors: JUAN JOSE DÍAZ MOCHÓN
Title: CRISPNA, A NEW TOOL FOR GENOME EDITING AND DIAGNOSIS
Dress: P202031322
Application date: 30 / 12 / 2020
Inventors: CANO CORTÉS VICTORIA
Title: 8-METHOXY-2-OXO-1,2-DIHYDROCYCLOPENTA[DE]QUINOLINE DERIVATIVES AND THEIR APPLICATION AS LABELING REAGENTS FOR LANTHANIDE LUMINESCENT
Dress: P202030075
Application date: 31 / 01 / 2020
A novel colorimetric assay for early differentiation of mucocutaneous and cutaneous leishmaniasis via species-specific identification
TALANTA, 2025;
FI: 6,1; Q1
Advanced delivery systems for gene editing: A comprehensive review from the GenE-HumDi COST Action Working Group
MOLECULAR THERAPY-NUCLEIC ACIDS, 2025;
FI: 6,1; Q1
CD44-targeted N-benzyltetrahydroisoquinoline derivatives as anticancer agents with high tumor-to-normal cell selectivity
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025;
FI: 5,9; Q1
Amplification-Free Testing of microRNA Biomarkers in Cancer
CANCER, 2025;
FI: 4,4; Q2
Applying click chemistry principles to the design of tumor-targeted nanosystems
NANOMEDICINE, 2025;
FI: 3,9; Q2
Autologous patient-derived exhausted nano T-cells exploit tumor immune evasion to engage an effective cancer therapy
MOLECULAR CANCER, 2024;
FI: 27,7; D1
Multiplexed MicroRNA biomarker detection by bridging lifetime filtering imaging and dynamic chemical labeling
B-CHEMICAL SENSORS AND ACTUATORS, 2024;
FI: 8; D1
Click chemistry-based dual nanosystem for microRNA-122 detection with single-base specificity from tumor cells
JOURNAL OF NANOBIOTECHNOLOGY, 2024;
FI: 10,6; D1
Tuning singlet oxygen generation with caged organic photosensitizers
NATURE COMMUNICATIONS, 2024;
FI: 14,7; D1
A Pd-labile fluoroquinolone prodrug efficiently prevents biofilm formation on coated surfaces
ORGANIC & BIOMOLECULAR CHEMISTRY, 2024;
FI: 2,9; Q1
Spatial Transcriptomics: Emerging Technologies in Tissue Gene Expression Profiling
ANALYTICAL CHEMISTRY, 2023;
FI: 7,4; D1
SARS-CoV-2 viral RNA detection using the novel CoVradar device associated with the CoVreader smartphone app
BIOSENSORS & BIOELECTRONICS, 2023;
FI: 12,6; D1
Direct detection of alpha satellite DNA with single-base resolution by using abasic Peptide Nucleic Acids and Fluorescent in situ Hybridization
BIOSENSORS & BIOELECTRONICS, 2023;
FI: 12,6; D1
Identification of compounds with activity against Trypanosoma cruzi within a collection of synthetic nucleoside analogs
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, 2023;
FI: 5,7; Q2
Symmetric 4,6-dialkyl/arylamino-5-nitropyrimidines: theoretical explanation of why aminolysis of alkoxy groups is favored over chlorine aminolysis in nitro-activated pyrimidines
NEW JOURNAL OF CHEMISTRY, 2023;
FI: 3,3; Q2
A 5-FU Precursor Designed to Evade Anabolic and Catabolic Drug Pathways and Activated by Pd Chemistry In Vitro and In Vivo
JOURNAL OF MEDICINAL CHEMISTRY, 2022;
FI: 8,039; D1
Hybrid Fluorescent Mass-Tag Nanotrackers as Universal Reagents for Long-Term Live-Cell Barcoding
ANALYTICAL CHEMISTRY, 2022;
FI: 8,008; D1
Reversal of mitochondrial malate dehydrogenase 2 enables anaplerosis via redox rescue in respiration-deficient cells
MOLECULAR CELL, 2022;
FI: 19,328; D1
A Novel, Quick, and Reliable Smartphone-Based Method for Serum PSA Quantification: Original Design of a Portable Microfluidic Immunosensor-Based System.
CANCER, 2022;
FI: 6,575; Q1
Isogenic GAA-KO Murine Muscle Cell Lines Mimicking Severe Pompe Mutations as Preclinical Models for the Screening of Potential Gene Therapy Strategies
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2022;
FI: 6,208; Q1
DatAC: A visual analytics platform to explore climate and air quality indicators associated with the COVID-19 pandemic in Spain
SCIENCE OF THE TOTAL ENVIRONMENT, 2021;
FI: 7,963; D1
An effective polymeric nanocarrier that allows for active targeting and selective drug delivery in cell coculture systems
NANOSCALE, 2021;
FI: 7,79; Q1
Cross-Resistance to Abiraterone and Enzalutamide in Castration Resistance Prostate Cancer Cellular Models Is Mediated by AR Transcriptional Reactivation.
CANCER, 2021;
FI: 6,639; Q1
Development of a nanotechnology-based approach for capturing and detecting nucleic acids by using flow cytometry
TALANTA, 2021;
FI: 6,057; Q1
A minimally-masked inactive prodrug of panobinostat that is bioorthogonally activated by gold chemistry
BIOORGANIC & MEDICINAL CHEMISTRY, 2021;
FI: 3,641; Q2
Bioorthogonal Uncaging of Cytotoxic Paclitaxel through Pd Nanosheet-Hydrogel Frameworks
JOURNAL OF MEDICINAL CHEMISTRY, 2020;
FI: 6,205; D1
A versatile theranostic nanodevice based on an orthogonal bioconjugation strategy for efficient targeted treatment and monitoring of triple negative breast cancer
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, 2020;
FI: 5,182; Q1
Amplification-free profiling of microRNA-122 biomarker in DILI patient serums, using the luminex MAGPIX system
TALANTA, 2020;
FI: 5,339; Q1
Challenges and opportunities of cfDNA analysis implementation in clinical practice: Perspective of the International Society of Liquid Biopsy (ISLB)
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY, 2020;
FI: 5,833; Q1
Characterization and Therapeutic Effect of a pH Stimuli Responsive Polymeric Nanoformulation for Controlled Drug Release
POLYMERS, 2020;
FI: 3,426; Q1
Integration of DCL and DTT technologies for multiplexed miRNA analysis on Luminex xMAP platforms: proof of concept for non-invasive diagnosis and monitoring of Alzheimer's
Funder: UNIVERSITY OF GRANADA
File number: P31/24/05
Execution time: 01/01/2026 - 31/12/2026
IP: VICTORIA CANO CORTES
Early detection of pancreatic cancer through mutational biomarker analysis in liquid biopsies of patients using an innovative platform based on highly specific CRISPR-Cas13
Funder: MINISTRY OF HEALTH, PRESIDENCY AND EMERGENCIES
File number: PIP-0004-2025
Execution time: 25/11/2025 - 25/11/2028
IP: JUAN JOSE DIAZ MOCHON
Tumor-targeting nanoengineered technologies for in situ activation of small drug molecules to fight cancer
Funder: STATE RESEARCH AGENCY
File number: PID2023-147912OA-I00
Execution time: 01/09/2024 - 31/12/2028
IP: MARIA DEL CARMEN ORTEGA LIEBANA
Validation of a Protocol for Labeling Based on Nanotechnology and Single Domain Antibodies for the Multiparallel Phenotypic Analysis of CTCs in Liquid Biopsy
Funder: HEALTH AND CONSUMPTION COUNCIL
File number: PIP-0245-2024
Execution time: 29/11/2024 - 29/11/2027
IP: VICTORIA CANO CORTES
Potential of peptide nucleic acids as guides for RNA-targeting CRISPR-Cas systems: a pioneering study (CRISPNA).
Funder: STATE RESEARCH AGENCY
File number: PID2022-141065OB-I00
Execution time: 01/09/2023 - 31/08/2027
IP: JUAN JOSE DIAZ MOCHON
Development of a diagnostic assay based on single-domain antibodies against new tumor biomarkers using mass cytometry.
Funder: PUBLIC FOUNDATION FOR BIOSANITARY RESEARCH OF ORIENTAL ANDALUCIA ALEJANDRO OTERO (FIBAO)
File number: INTRAIBS-2022-01
Execution time: 20/01/2023 - 30/01/2024
IP: VICTORIA CANO CORTES
DEVELOPMENT OF PLASMONIC POLYMERIC NANOSPHERES LOADED WITH FLUORESCENT CHOLINE KINASE INHIBITORS FOR COMBINED CHEMO-PHOTOTHERMAL CANCER THERAPY
Funder: DEPARTMENT OF UNIVERSITY, RESEARCH AND INNOVATION
File number: ProyExcel_00061
Execution time: 01/01/2023 - 31/12/2025
IP: BELEN RUBIO RUIZ
Nano3Devices2Clinic v2.0: Advanced prototype of a versatile nanosystem with theranostic application in cancer
Funder: DEPARTMENT OF UNIVERSITY, RESEARCH AND INNOVATION
File number: AT21_00246
Execution time: 01/01/2022 - 31/05/2023
PI: ROSARIO MARIA SANCHEZ MARTIN
Platform validation for the capture, labeling and analysis of exosomes by mass cytometry (EXO-Magbeads).
Funder: STATE RESEARCH AGENCY
File number: PDC2022-133913-I00
Execution time: 01/12/2022 - 30/11/2024
PI: ROSARIO MARIA SANCHEZ MARTIN
Capture of Extracellular Vesicles of T cells and its relationship with T cell-mediated immunity
Funder: UNIVERSITY OF GRANADA
File number: P32/22/02
Execution time: 01/11/2022 - 31/10/2024
IP: MARIA TERESA VALERO GRIÑAN
Platform development for isolation; labeling and analysis of individual exosomes by mass cytometry
Funder: UNIVERSITY OF GRANADA
File number: A-FQM-760-UGR20
Execution time: 01/07/2021 - 30/06/2023
IP: JUAN JOSE DIAZ MOCHON
Development of diagnostic assays based on single domain antibodies against new tumor biomarkers
Funder: COUNCIL OF HEALTH AND FAMILIES
File number: PIP-0232-2021
Execution time: 10/12/2021 - 09/12/2024
PI: ROSARIO MARIA SANCHEZ MARTIN
TARGETOF – Mass cytometry nanotools for intracellular target engagement. Towards precision medicine.
Funder: EUROPEAN COMMISSION
File number: 895664
Execution time: 01/09/2021 - 30/09/2023
PI: ROSARIO MARIA SANCHEZ MARTIN
DIARNAGNOSIS: A novel platform for the direct profiling of circulating cell-free ribonucleic acids in biofluids
Funder: EUROPEAN COMMISSION
File number: 101007934
Execution time: 01/01/2021 - 31/12/2024
PI: ROSARIO MARIA SANCHEZ MARTIN
Multifunctionalized nanosystem for cancer theranostic Multifunctionalized nanosystem for cancer theranostic Multifunctionalized nanosystem for cancer theranostic
Funder: UNIVERSITY OF GRANADA
File number: PSETC - PSE / 16/003
Execution time: 01/01/2017 - 31/12/2018
PI: ROSARIO MARIA SANCHEZ MARTIN
Multifunctional nano-system with theragnostic application in cancer
Funder: UNIVERSITY OF GRANADA
File number: UGR001 / B-16
Execution time: 01/01/2017 - 31/12/2018
PI: ROSARIO MARIA SANCHEZ MARTIN
Detection of circulating nucleic acids and their mutations using pcr-free protocols. Integration of nanotechnology, dynamic chemistry and mass cytometry.
Funder: MINISTRY OF ECONOMY AND COMPETITIVENESS
File number: BIO2016-80519-R
Execution time: 30/12/2016 - 29/12/2019
PI: ROSARIO MARIA SANCHEZ MARTIN
NANO3DEVICES: MULTIFUNCTIONAL NANOSYSTEM WITH TERANOSTIC APPLICATION IN CANCER
Funder: CARLOS III HEALTH INSTITUTE - FEDER
File number: DTS18 / 00121
Execution time: 01/01/2019 - 31/12/2020
PI: ROSARIO MARIA SANCHEZ MARTIN
