TEC24-Hematology and Gene Therapy Research Group: HemaTerGe
Advanced Therapies and Biomedical Technologies / IBS-TEC24 / Consolidated
The overall objective of HemaTerGe is to deepen the biological and clinical knowledge of haematological diseases in order to improve their prognosis and generate efficient, safe and cost-effective advanced therapy medicines (ATMP) for the treatment of haematological diseases, cancer and monogenetic diseases. This objective requires collaboration and coordination between scientists, physicians and other stakeholders (pharmaceutical companies, regulators, patients, etc.) to provide regulatory preclinical data and facilitate their application to the national health system. In particular, the new HemaTerGe group seeks to advance the treatment of haematological diseases, with a special focus on cancer and monogenetic diseases. To this end, the group has basic researchers who are experts in gene therapy and genome editing and clinical researchers with extensive experience in research into different haematological diseases and in conducting clinical trials.
Research lines
- Preclinical research into advanced therapies for the treatment of cancer.
- Preclinical research into advanced therapies for the treatment of monogenic diseases.
- Proposals for “first-in-human” clinical trials in Advanced Therapies.
- Hematopoietic Transplantation and Cell Therapy
- Lymphoid and Myeloid Neoplasms
- Coagulation and Hemostasis
- Psycho-emotional sphere and quality of life.
Research networks
- REDTERAV - Advanced Therapies
- CA21113 - Genome Editing to Treat Humans Diseases (GenE-Humdi)
Keywords
CAR-T, 2. Lymphoid and Myeloid Neoplasms, Cell Therapy, monogenic diseases
Antonio Matilla Serrano
MARIA TRISTAN MANZANO
Alberto Tagliaferro Quinonero
JON RUIZ DE FRANCISCO
ANTONIO ROMERO AGUILAR
IRIS RAMOS HERNANDEZ
KRISTINA PAVLOVIC PAVLOVIC
AMANDA NUÑEZ GARCIA
LUCIA MORATALLA LOPEZ
BEATRIZ MESA SIMON
Elena Masana Flowers
ELISA LOPEZ FERNANDEZ
MANUEL JOURNEY CHACON
ANA HINCKLEY BONED
FRANCISCA HERNANDEZ MOHEDO
PEDRO ANTONIO GONZALEZ SIERRA
PABLO GALLINDO NAVARRO
LAURA TRAINS UREÑA
Alicia Delgado Garcia
LINARES FERNANDEZ LONELINESS
Antonio Jesus Cruz Diaz
Marina Cortijo Gutierrez
Maria Esther Clavero Sanchez
Carlos Blanco Benitez
JOSE MANUEL DOOR DOOR
FRANCISCO JAVIER MOLINA ESTEVEZ
PILAR MUÑOZ FERNANDEZ
VERONICA AYLLON CASES
FRANCISCO MARTIN MOLINA
RICORS Advanced therapies: TERAV+ NETWORK
Funder: Carlos III Health Institute - PRTR
File number: RD24 / 0014/0005
Execution time: 01/01/2025 - 31/12/2027
IP: FRANCISCO MARTIN MOLINA
Lymphocyte engineering for the generation of universal and inducible CAR-T cells for immunotherapy of refractory lymphomas
Funder: HEALTH AND CONSUMPTION COUNCIL
File number: PI-0236-2024
Execution time: 28/11/2024 - 29/11/2027
IP: FRANCISCO MARTIN MOLINA
Overcoming limitations to strengthen and enhance gene therapy strategies for the treatment of Pompe disease.
Funder: CARLOS III HEALTH INSTITUTE - FEDER
File number: PI24 / 00216
Execution time: 01/01/2025 - 31/12/2027
IP: Pilar Muñoz Fernandez
Development of inducible 4th-generation CAR-T cells for the treatment of solid tumors
Funder: CARLOS III HEALTH INSTITUTE - FEDER
File number: PI24 / 00888
Execution time: 01/01/2025 - 31/12/2027
IP: FRANCISCO MARTIN MOLINA
Spanish Registry of Primary Immune Thrombocytopenia and other immune thrombocytopenias.
Funder: Spanish Foundation for Hematology and Hemotherapy
Test type: OBSERVATIONAL STUDY WITH MEDICINES
Execution time: 19/12/24 - 31/12/34
IP: LAURA ENTRENA UREÑA
Impact of CMV-specific immune reconstitution at the end of Letermovir prophylaxis on the development of late cytomegalovirus infection in patients with hematopoietic progenitor cell transplantation (INMUNOEND Study).
Funder: FIBICO. BIOMEDICAL RESEARCH FOUNDATION OF CÓRDOBA
Test type: OBSERVATIONAL STUDY WITH MEDICINES
Execution time: 25/11/24 - 31/12/27
PI: PEDRO ANTONIO GONZALEZ SIERRA
Analysis of patients with chronic lymphocytic leukemia (CLL) who discontinue BTK inhibitor monotherapy without disease progression.
Funder: Spanish Chronic Lymphocytic Leukemia Group
Test type: OBSERVATIONAL STUDY WITH MEDICINES
Execution time: 30/10/24 - 28/02/25
IP: JOSE M PUERTA PUERTA
Cross-sectional study to evaluate perceptions of physical activity in patients with hemophilia A treated with emicizumab. HEMO-ACT STUDY
Financier: ROCHE FARMA, SA
Test type: OBSERVATIONAL STUDY WITH MEDICINES
Execution time: 23/04/2024 - 30/03/2025
IP: LAURA ENTRENA UREÑA
A phase II, open-label, randomized, multicenter trial to evaluate the safety and efficacy of axatilimab in combination with ruxolitinib in participants with newly diagnosed chronic graft-versus-host disease.
Financer: INCYTE CORPORATION
Type of test: CLINICAL TRIAL WITH DRUGS
Execution time: 04/07/2024 - 30/09/2028
PI: MANUEL JURADO CHACON
Phase II dose-finding and interception study of linvoseltamab in patients with high-risk monoclonal gammopathy of undetermined extent or non-high-risk asymptomatic multiple myeloma.
Funder: ICON CLINICAL RESEARCH LTD
Type of test: CLINICAL TRIAL WITH DRUGS
Execution time: 22/08/2024 - 26/06/2032
IP: MARIA ESTHER CLAVERO SANCHEZ
Phase II study of linvoseltamab in patients with asymptomatic multiple myeloma at high risk of progression to multiple myeloma.
Funder: ICON CLINICAL RESEARCH LTD
Type of test: CLINICAL TRIAL WITH DRUGS
Execution time: 29/01/2024 - 29/08/2032
IP: MARIA ESTHER CLAVERO SANCHEZ
A phase IIb, multicenter, randomized, double-blind trial evaluating combined oral fecal microbiotherapy MaaT033 for preventing complications of allogeneic hematopoietic stem cell transplantation. (PHOEBUS Trial)
Funder: ICON CLINICAL RESEARCH LTD
Type of test: CLINICAL TRIAL WITH DRUGS
Execution time: 21/02/2024 - 30/06/2027
PI: MANUEL JURADO CHACON