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TEC24-Hematology and Gene Therapy Research Group: HemaTerGe

Advanced Therapies and Biomedical Technologies / IBS-TEC24 / Consolidated

ibs.GRANADA  ·  Research groups
  • Information
  • Members
  • Projects
  • Clinical trials

The overall objective of HemaTerGe is to deepen the biological and clinical knowledge of haematological diseases in order to improve their prognosis and generate efficient, safe and cost-effective advanced therapy medicines (ATMP) for the treatment of haematological diseases, cancer and monogenetic diseases. This objective requires collaboration and coordination between scientists, physicians and other stakeholders (pharmaceutical companies, regulators, patients, etc.) to provide regulatory preclinical data and facilitate their application to the national health system. In particular, the new HemaTerGe group seeks to advance the treatment of haematological diseases, with a special focus on cancer and monogenetic diseases. To this end, the group has basic researchers who are experts in gene therapy and genome editing and clinical researchers with extensive experience in research into different haematological diseases and in conducting clinical trials.

Research lines

  • Preclinical research into advanced therapies for the treatment of cancer.
  • Preclinical research into advanced therapies for the treatment of monogenic diseases.
  • Proposals for “first-in-human” clinical trials in Advanced Therapies.
  • Hematopoietic Transplantation and Cell Therapy
  • Lymphoid and Myeloid Neoplasms
  • Coagulation and Hemostasis
  • Psycho-emotional sphere and quality of life.

Research networks

  • REDTERAV - Advanced Therapies
  • CA21113 - Genome Editing to Treat Humans Diseases (GenE-Humdi)

Keywords

CAR-T, 2. Lymphoid and Myeloid Neoplasms, Cell Therapy, monogenic diseases

Antonio Matilla Serrano

MARIA TRISTAN MANZANO

  • ORCID

Alberto Tagliaferro Quinonero

  • ORCID

JON RUIZ DE FRANCISCO

ANTONIO ROMERO AGUILAR

IRIS RAMOS HERNANDEZ

  • ORCID

KRISTINA PAVLOVIC PAVLOVIC

  • ORCID

AMANDA NUÑEZ GARCIA

LUCIA MORATALLA LOPEZ

BEATRIZ MESA SIMON

Elena Masana Flowers

ELISA LOPEZ FERNANDEZ

MANUEL JOURNEY CHACON

  • ORCID

ANA HINCKLEY BONED

  • ORCID

FRANCISCA HERNANDEZ MOHEDO

  • ORCID

PEDRO ANTONIO GONZALEZ SIERRA

PABLO GALLINDO NAVARRO

LAURA TRAINS UREÑA

Alicia Delgado Garcia

LINARES FERNANDEZ LONELINESS

Antonio Jesus Cruz Diaz

Marina Cortijo Gutierrez

  • ORCID

Maria Esther Clavero Sanchez

Carlos Blanco Benitez

  • ORCID

JOSE MANUEL DOOR DOOR

  • Request More Information
  • ORCID

FRANCISCO JAVIER MOLINA ESTEVEZ

  • ORCID

PILAR MUÑOZ FERNANDEZ

  • ORCID

VERONICA AYLLON CASES

  • ORCID

FRANCISCO MARTIN MOLINA

  • Request More Information
  • ORCID

RICORS Advanced therapies: TERAV+ NETWORK

Funder: Carlos III Health Institute - PRTR

File number: RD24 / 0014/0005

Execution time: 01/01/2025 - 31/12/2027

IP: FRANCISCO MARTIN MOLINA

Lymphocyte engineering for the generation of universal and inducible CAR-T cells for immunotherapy of refractory lymphomas

Funder: HEALTH AND CONSUMPTION COUNCIL

File number: PI-0236-2024

Execution time: 28/11/2024 - 29/11/2027

IP: FRANCISCO MARTIN MOLINA

Overcoming limitations to strengthen and enhance gene therapy strategies for the treatment of Pompe disease.

Funder: CARLOS III HEALTH INSTITUTE - FEDER

File number: PI24 / 00216

Execution time: 01/01/2025 - 31/12/2027

IP: Pilar Muñoz Fernandez

Development of inducible 4th-generation CAR-T cells for the treatment of solid tumors

Funder: CARLOS III HEALTH INSTITUTE - FEDER

File number: PI24 / 00888

Execution time: 01/01/2025 - 31/12/2027

IP: FRANCISCO MARTIN MOLINA

Spanish Registry of Primary Immune Thrombocytopenia and other immune thrombocytopenias.

Funder: Spanish Foundation for Hematology and Hemotherapy

Test type: OBSERVATIONAL STUDY WITH MEDICINES

Execution time: 19/12/24 - 31/12/34

IP: LAURA ENTRENA UREÑA

Impact of CMV-specific immune reconstitution at the end of Letermovir prophylaxis on the development of late cytomegalovirus infection in patients with hematopoietic progenitor cell transplantation (INMUNOEND Study).

Funder: FIBICO. BIOMEDICAL RESEARCH FOUNDATION OF CÓRDOBA

Test type: OBSERVATIONAL STUDY WITH MEDICINES

Execution time: 25/11/24 - 31/12/27

PI: PEDRO ANTONIO GONZALEZ SIERRA

Analysis of patients with chronic lymphocytic leukemia (CLL) who discontinue BTK inhibitor monotherapy without disease progression.

Funder: Spanish Chronic Lymphocytic Leukemia Group

Test type: OBSERVATIONAL STUDY WITH MEDICINES

Execution time: 30/10/24 - 28/02/25

IP: JOSE M PUERTA PUERTA

Cross-sectional study to evaluate perceptions of physical activity in patients with hemophilia A treated with emicizumab. HEMO-ACT STUDY

Financier: ROCHE FARMA, SA

Test type: OBSERVATIONAL STUDY WITH MEDICINES

Execution time: 23/04/2024 - 30/03/2025

IP: LAURA ENTRENA UREÑA

A phase II, open-label, randomized, multicenter trial to evaluate the safety and efficacy of axatilimab in combination with ruxolitinib in participants with newly diagnosed chronic graft-versus-host disease.

Financer: INCYTE CORPORATION

Type of test: CLINICAL TRIAL WITH DRUGS

Execution time: 04/07/2024 - 30/09/2028

PI: MANUEL JURADO CHACON

Phase II dose-finding and interception study of linvoseltamab in patients with high-risk monoclonal gammopathy of undetermined extent or non-high-risk asymptomatic multiple myeloma.

Funder: ICON CLINICAL RESEARCH LTD

Type of test: CLINICAL TRIAL WITH DRUGS

Execution time: 22/08/2024 - 26/06/2032

IP: MARIA ESTHER CLAVERO SANCHEZ

Phase II study of linvoseltamab in patients with asymptomatic multiple myeloma at high risk of progression to multiple myeloma.

Funder: ICON CLINICAL RESEARCH LTD

Type of test: CLINICAL TRIAL WITH DRUGS

Execution time: 29/01/2024 - 29/08/2032

IP: MARIA ESTHER CLAVERO SANCHEZ

A phase IIb, multicenter, randomized, double-blind trial evaluating combined oral fecal microbiotherapy MaaT033 for preventing complications of allogeneic hematopoietic stem cell transplantation. (PHOEBUS Trial)

Funder: ICON CLINICAL RESEARCH LTD

Type of test: CLINICAL TRIAL WITH DRUGS

Execution time: 21/02/2024 - 30/06/2027

PI: MANUEL JURADO CHACON

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Responsible researcher

JOSE MANUEL DOOR DOOR

  • josem.puerta.sspa@juntadeandalucia.es
  • Request More Information
  • ORCID

Responsible Co-Investigator

FRANCISCO MARTIN MOLINA

  • franciscomm@ugr.es
  • Request More Information
  • ORCID

Research

  • Collaboration network between groups of the ibs.GRANADA
  • Oncology Area
  • Epidemiology and Public Health Area
  • Precision Medicine Area
  • Advanced Therapies and Biomedical Technologies Area
  • Clinical research

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