TEC16-Advanced Therapies: Differentiation, Regeneration and Cancer

Information
Members
Patents
Publications
Projects

The group's research focuses on two main axes, regenerative medicine and experimental oncology, not only in the basic aspects, but also clearly translational and interdisciplinary, with application in diagnosis and therapeutic use to benefit the health of patients with highly prevalent diseases, such as degenerative diseases and cancer. This multi and interdisciplinary orientation is based on the use of knowledge in nanotechnology and nanomedicine to meet the above objectives.

Research lines

Therapeutic application of adult and progenitor stem cells in pathologies
3D bioprinting of tumors, tumors-on-a-chip and metastasis-on-chip
3D bioprinting and biotin development and generation of natural and synthetic biomaterials with application of prevalent pathologies
Liquid biopsy: identification of new biomarkers and extracellular vesicles characteristic of CSCs with prognostic and predictive value of response in cancer patients
Development of bioreactors with application in regenerative medicine
Development of preclinical models for new useful treatments in regenerative medicine and cancer.
Development of biological nanosystems based on cell membranes (noghosts)
Development of new medical devices for the treatment of cancer (ultrasound)
Development of chemical platforms for the detection of nucleic acids
Implementation of intelligent theranostic nanomedicines
Implementation of a non-invasive integrated platform based on the use of bioinformatics, nanotechnology and graphene biosensors
Integration of nanotechnology with dynamic chemistry as a diagnostic tool
New natural and synthetic drugs selective against CSCs
Organoids-on-a-chip
Role of cancer stem cells (CSCs) and their microenvironment in tumor development.
Cancer gene therapy: suicide genes and CAR-T systems for solid tumors
Use of chimeric cytokines in cell differentiation

Research networks

CA21108 - European Network for Skin Engineering and Modeling (NETSKINMODELS)

Keywords

stem cells, cancer stem cells, 3D bioprinting, labs-on-chip, nanoparticles, nano-ghosts, teragnosis, exosomes, liquid biopsy, gene therapy, suicide genes, bioreactors, medical devices, dynamic chemistry, biosensors

ALICIA RUIZ RODRIGUEZ

ORCID

Ana Belen Diaz Ruano

ORCID

Ana Voltes Martinez

Jesus Ruiz Espigares

ORCID

Laura Garrido Martin

Elisa Nygren Jimenez

Alba Hidalgo Ramirez

NIEVES CASILLAS RUIZ

ORCID

Giselle Xavier Reis

ORCID

ANDREA MORENO REVUELTA

ORCID

Maria Dolores Gomez Capel

AITOR GONZALEZ TITOS

ORCID

MARIA DEL CARMEN HERNANDEZ VALLADARES

ORCID

ALFONSO RUBIO NAVARRO

ORCID

MARIA PAZ DE LA ZAFRA MARTIN

DANIEL NIETO GARCIA

PABLO GRAVAN JIMENEZ

ORCID

JUAN ANTONIO MARCHAL CORRALES

SAUL ABENHAMAR NAVARRO MARCHAL

ORCID

JOSE LUIS PALACIOS FERRER

ORCID

ANTONIO PALOMEQUE JIMENEZ

ORCID

MANUEL PICON RUIZ

GLORIA RUIZ ALCALA

ORCID

FRANCISCO JESUS ARREBOLA VARGAS

HOURIA BOULAIZ TASSI

ORCID

ESMERALDA CARRILLO SLIM

ORCID

MARIA EUGENIA GARCIA RUBIÑO

ORCID

MARIA ANGEL GARCIA CHAVES

MICHAEL HACKENBERG

GEMA JIMENEZ GONZALEZ

ELENA LOPEZ RUIZ

ORCID

MARGARITA AGUILERA GOMEZ

Inventors: AGUILERA GOMEZ MARGARITA; ARANEGA JIMENEZ ANTONIA; CALLEJA HERNANDEZ MIGUEL ANGEL; CARRASCO PARDO ESTHER; ESTEBAN RODRIGUEZ MARIANO; GARCIA CHAVES MARIA ANGEL; JIMENEZ GONZALEZ GEMA; MARCHAL CORRALES JUAN ANTONIO;
Title: METHOD OF OBTAINING USEFUL DATA TO ASSESS THE RESPONSE TO TREATMENT WITH 5-FLUOROURACILO (5-FU)
Code: P201130247

Inventors: ARANEGA JIMENEZ ANTONIA; BOULAIZ HOURIA; CAMPOS ROSA JOAQUIN MARIA; CATIVIELA MARIN CARLOS; CHOQUESILLO-LAZARTE DUANE; RABBIT GARCIA ANA; CRUZ LOPEZ OLGA; GARCIA CHAVES MARIA ANGEL; GARCIA RUIZ JUAN MANUEL; JIMENEZ SANZ ANA ISABEL; MARCHAL
Title: BENZOHETEROEPINE TARGETS
Code: P201030415

Inventors: A. Aránega; ALVAREZ DE MANZANEDA ROLDAN ENRIQUE; CHAHBOUN RACHID; F. Rodríguez Serrano; I. Messouri; H. Boulaiz; JA Marchal; C. Melguizo; M. Perán; J. Prados;
Title: SYNTHETIC ANALOGS OF MEROSESQUITERPENES AND COMPOUNDS RELATED TO ANTI-TUMOR ACTIVITY
Code: P201050019

Inventors: Campos JM; Lopez l; Marchal JA; Boulaiz H; Aránega A; Rooster MA; Espinosa A; Rodríguez-Serrano F; Rabbit, Ana
Title: NEW (RS) - 7- O 9- (1,2,3,5- TETRAHIDRO-4,1-BENZOCAZEPIN-3-IL) -7H O9H-PURINES WITH ANTI-TUMOR ACTIVITY
Code: P200802431

Inventors: ARANEGA JIMENEZ ANTONIA; CAMPOS ROSA JOAQUIN; ESPINOSA UBEDA ANTONIO; GALLO MEZO MIGUEL ANGEL; GOMEZ VIDAL JOSE ANTONIO; NUNEZ CARRETERO M DEL CARMEN; MARCHAL CORRALES JUAN ANTONIO; Rodriguez-Serrano F;
Title: (2,3-DIHYDRO-5H-1,4-BENZODIHETEROEPIN-3-IL) PURINES WITH ANTI-TUMOR ACTIVITY
Code: P200601538

González-Olmedo, C; García-Verdejo, FJ; Reguera-Teba, A; Rosa-Garrido, C; López-López, J.A.; Díaz-Beltrán, L.; García, PM; Luque-Caro, N; Gálvez-Montosa, F; Ortega-Granados, A.L.; Ruiz-Sanjuan, M; Cózar-Ibáñez, A; Sainz, J; Marchal, J.A.; Camacho, J; del Palacio, J.P.; Fernández-Godino, R; Díaz, C; Sánchez-Rovira, P

Metabolomics signature as a survival predictor in patients with resectable colorectal liver metastasis

CLINICAL AND TRANSLATIONAL MEDICINE, 2024;

FI: 7,9; D1

Peña-Martín, J; García-Ortega, MB; Palacios-Ferrer, JL; Díaz, C; Garcia, MA; Boulaiz, H; Valdivia, J; Jury, JM; Almazan-Fernandez, FM; Santiago, SA; Vicente, F; del Val, C; del Palacio, JP; Marchal, J.A.

Identification of novel biomarkers in the early diagnosis of malignant melanoma by untargeted liquid chromatography coupled to high-resolution mass spectrometry-based metabolomics: a pilot study

BRITISH JOURNAL OF DERMATOLOGY, 2024;

FI: 11; D1

Calahorra, J; Blaya-Cánovas, JL; Castellini-Perez, O; Aparicio-Puerta, E; Cives-Losada, C; Marin, J.J.G. Rementeria, M; Face, FAITH; López-Tejada, A; Griñán-Lisón, C; Aulicino, F; Berger, I; Marchal, JA; Delgado-Almenta, V; Granados-Principal, S

Unlocking the effective alliance of β-lapachone and hydroxytyrosol against triple-negative breast cancer cells

BIOMEDICINE & PHARMACOTHERAPY, 2024;

FI: 6,9; D1

Blaya-Cánovas, JL; Griñán-Lisón, C; Blancas, I; Marchal, JA; Ramírez-Tortosa, C; López-Tejada, A; Benabdellah, K; Cortijo-Gutiérrez, M; Cano-Cortés, MV; Graván, P; Navarro-Marchal, SA; Gómez-Morales, J; Delgado-Almenta, V; Calahorra, J; Agudo-Lera, M; Sagarzazu, A; Rodríguez-González, CJ; Gallart-Aragón, T; Eich, C; Sánchez-Martín, RM; Granados-Principal, S

Autologous patient-derived exhausted nano T-cells exploit tumor immune evasion to engage an effective cancer therapy

MOLECULAR CANCER, 2024;

FI: 27,7; D1

de Andres, JL; Rodríguez-Santana, C; de Lara-Peña, L; Jiménez, G; Escames, G; Marchal, J.A.

A bioengineered tumor matrix-based scaffold for the evaluation of melatonin efficacy on head and neck squamous cancer stem cells

MATERIALS TODAY BIO, 2024;

FI: 8,7; D1

Lopez-Tejada, A; Grinan-Lison, C; Gonzalez-Gonzalez, A; Cara, FE; Luque, RJ; Rosa-Garrido, C; Blaya-Cananovas, JL; Navarro-Ocon, A; Valenzuela-Torres, M; Parra-Lopez, M; Calahorra, J; Blancas, I; Marchal, JA; Granados-Principal, S

TGFß Governs the Pleiotropic Activity of NDRG1 in Triple-Negative Breast Cancer Progression

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES, 2023;

FI: 9,2; Q1

Diaz-Ruano, AB; Martinez-Alarcon, N; Perán, M; Benabdellah, K; Garcia-Martinez, MD; Preda, O; Ramirez-Tortosa, C; Gonzalez-Hernandez, A; Marchal, JA; Picon-Ruiz, M

Estradiol and Estrone Have Different Biological Functions to Induce NF-κB-Driven Inflammation, EMT and Stemness in ER plus Cancer Cells

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023;

FI: 6,208; Q1

Ruiz-Malagón, AJ; Hidalgo-García, L; Rodríguez-Sojo, MJ; Molina-Tijeras, JA; García, F; Diez-Echave, P; Vezza, T; Becerra, P; Marchal, JA; Redondo-Cerezo, E; Hausmann, M; Rogler, G; Garrido-Mesa, J; Rodríguez-Cabezas, ME; Rodríguez-Nogales, A; Gálvez, J

Tigecycline reduces tumorigenesis in colorectal cancer via inhibition of cell proliferation and modulation of immune response

BIOMEDICINE & PHARMACOTHERAPY, 2023;

FI: 7,5; Q1

Garcia-Ortega, MB; Aparicio, E; Griñán-Lisón, C; Jiménez, G; López-Ruiz, E; Palacios, JL; Ruiz-Alcalá, G; Alba, C; Martínez, A; Boulaiz, H; Perán, M; Hackenberg, M; Bragança, J; Calado, SM; Marchal, JA; Garcia, MA

Interferon-Alpha Decreases Cancer Stem Cell Properties and Modulates Exosomes in Malignant Melanoma

CANCER, 2023;

FI: 5,2; Q2

Barungi, S; Hernández-Camarero, P; Moreno-Terribas, G; Villalba-Montoro, R; Marchal, JA; López-Ruiz, E; Peran, M

Clinical implications of inflammation in atheroma formation and novel therapies in cardiovascular diseases

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2023;

FI: 5,5; Q2

Pleguezuelos-Beltran, P; Galvez-Martin, P; Nieto-Garcia, D; Marchal, JA; Lopez-Ruiz, E

Advances in spray products for skin regeneration

BIOACTIVE MATERIALS, 2022;

FI: 16,874; D1

Grandson, D; Jimenez, G; Moroni, L; Lopez-Ruiz, E; Galvez-Martin, P; Marchal, J.A.

Biofabrication approaches and regulatory framework of metastatic tumor-on-a-chip models for precision oncology

MEDICINAL RESEARCH REVIEWS, 2022;

FI: 12,388; D1

Martinez-Moreno, D; Venegas-Bustos, D; Rus, G; Galvez-Martin, P; Jimenez, G; Marchal, J.A.

Chondro-Inductive b-TPUe-Based Functionalized Scaffolds for Application in Cartilage Tissue Engineering

ADVANCED HEALTHCARE MATERIALS, 2022;

FI: 11,092; D1

Razola-Diaz, MD; Gomez-Caravaca, AM; de Andres, JL; Voltes-Martinez, A; Zamora, A; Perez-Molina, GM; Castro, DJ; Marchal, JA; Verardo, V

Evaluation of Phenolic Compounds and Pigments Content in Yellow Bell Pepper Wastes

ANTIOXIDANTS, 2022;

FI: 7,675; D1

Gallardo, A; Molina, A; Asenjo, HG; Lopez-Onieva, L; Martorell-Marugan, J; Espinosa-Martinez, M; Grinan-Lison, C; Alvarez-Perez, JC; Face, FAITH; Navarro-Marchal, SA; Carmona-Saez, P; Medina, PP; Marchal, JA; Granados-Principal, S; Sanchez-Pozo, A; Landeira, D.

EZH2 endorses cell plasticity to non-small cell lung cancer cells facilitating mesenchymal to epithelial transition and tumor colonization

ONCOGENE, 2022;

FI: 8,756; D1

Navarro-Marchal, SA; Grinan-Lison, C; Train, JM; Ruiz-Alcala, G; Tristan-Manzano, M; Martin, F.; Perez-Victoria, I; Peula-Garcia, JM; Marchal, J.A.

Anti-CD44-Conjugated Olive Oil Liquid Nanocapsules for Targeting Pancreatic Cancer Stem Cells.

BIOMACROMOLECULES, 2021;

FI: 6,988; D1

Grinan-Lison, C; Blaya-Canovas, JL; Lopez-Tejada, A; Avalos-Moreno, M; Navarro-Ocon, A; Face, FE; Gonzalez-Gonzalez, A; Lorente, JA; Marchal, JA; Granados-Main, S

Antioxidants for the Treatment of Breast Cancer: Are We There Yet?..

ANTIOXIDANTS, 2021;

FI: 6,313; D1

Hernandez-Camarero, P; Lopez-Ruiz, E; Marchal, JA; Perán, M.

Cancer: a mirrored room between tumor bulk and tumor microenvironment

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 2021;

FI: 11,161; Q1

Torres-Sanchez, A; Pardo-Cacho, J; Lopez-Moreno, A; Ruiz-Moreno, A; Cerck, K; Aguilera, M.

Antimicrobial Effects of Potential Probiotics of Bacillus spp. Isolated from Human Microbiota: In Vitro and In Silico Methods.

MICROORGANISMS, 2021;

FI: 4,128; Q2

Gomez-Mateos, M; Arrebola, F; Navarro, MC; Romero, MC; Gonzalez, JM; Valero, A.

Acute Anisakiasis: Pharmacological Evaluation of Various Drugs in an Animal Model

DIGESTIVE DISEASES AND SCIENCES, 2021;

FI: 3,199; Q3

Antich, C; de Vicente, J; Jimenez, G; Chocarro, C; Carrillo, E; Montanez, E; Galvez-Martin, P; Marchal, J.A.

Bio-inspired hydrogel composed of hyaluronic acid and alginate as a potential bioink for 3D bioprinting of articular cartilage engineering constructs

BIOMATERIALIA ACT, 2020;

FI: 7,242; D1

Olivares-Urbano, MA; Grinan-Lison, C; Zurita, M; del Moral, R; Rios-Arrabal, S; Artacho-Cordon, F; Arrebola, JP; Gonzalez, AR; Leon, J; Marchal, J.A.; Nunez, MI

Matrix metalloproteases and TIMPs as prognostic biomarkers in breast cancer patients treated with radiotherapy: A pilot study

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2020;

FI: 4,658; Q1

Martinez, R.; Lopez-Trinidad, LM; Kapravelou, G; Arrebola, F; Galisteo, M; Aranda, P; Porres, JM; Lopez-Jurado, M.

A combined healthy strategy for successful weight loss, weight maintenance and improvement of hepatic lipid metabolism

JOURNAL OF NUTRITIONAL BIOCHEMISTRY, 2020;

FI: 4,873; Q1

Cano-Cortes, MV; Navarro-Marchal, SA; Ruiz-Blas, MP; Diaz-Mochon, JJ; Marchal, J.A.; Sanchez-Martin, R.M.

A versatile theranostic nanodevice based on an orthogonal bioconjugation strategy for efficient targeted treatment and monitoring of triple negative breast cancer

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, 2020;

FI: 5,182; Q1

Oberweis, CV; Marchal, J.A.; Lopez-Ruiz, E; Galvez-Martin, P.

A Worldwide Overview of Regulatory Frameworks for Tissue-Based Products

TISSUE ENGINEERING PART B-REVIEWS, 2020;

FI: 6,089; Q1

Chocarro-Wrona, C; Lopez-Ruiz, E; Peran, M; Galvez-Martin, P; Marchal, J.A.

Therapeutic strategies for skin regeneration based on biomedical substitutes

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY, 2019;

FI: 5,113; D1

Jimenez, G; Venkateswaran, S; Lopez-Ruiz, E; Peran, M; Pernagallo, S; Diaz-Monchon, JJ; Canadas, RF; Antich, C; Oliveira, JM; Callanan, A; Walllace, R; Reis, R.L.; Montanez, E; Carrillo, E; Bradley, M; Marchal, J.A.

A soft 3D polyacrylate hydrogel recapitulates the cartilage niche and allows growth-factor free tissue engineering of human articular cartilage

BIOMATERIALIA ACT, 2019;

FI: 6,638; D1

Lopez-Ruiz, E; Jimenez, G; from Cienfuegos, LA; Antich, C; Sabata, R; Marchal, JA; Galvez-Martin, P

ADVANCES OF HYALURONIC ACID IN STEM CELL THERAPY AND TISSUE ENGINEERING, INCLUDING CURRENT CLINICAL TRIALS

EUROPEAN CELLS & MATERIALS, 2019;

FI: 3,682; D1

Contreras-Montoya, R; Escolano, G; Roy, S; Lopez-Lopez, MT; Delgado-Lopez, JM; Cuerva, JM; Diaz-Mochon, JJ; Ashkenasy, N; Gavira, JA; from Cienfuegos, LA

Catalytic and Electron Conducting Carbon Nanotube-Reinforced Lysozyme Crystals

ADVANCED FUNCTIONAL MATERIALS, 2019;

FI: 15,621; D1

Detassis, S; Grasso, M; Tabraue-Chavez, M; Marin-Romero, A; Lopez-Longarela, B; Ilyine, H; Ress, C; Ceriani, S; Erspan, M; Maglione, A; Diaz-Mochon, JJ; Pernagallo, S; Dentis, MA

New Platform for the Direct Profiling of microRNAs in Biofluids

ANALYTICAL CHEMISTRY, 2019;

FI: 6,35; D1

Hackenberg, M; Kotsyfakis, M.

Exosome-Mediated Pathogen Transmission by Arthropod Vectors

TRENDS IN PARASITOLOGY, 2018;

FI: 7,929; D1

Melchor, J; Lopez-Ruiz, E; Soto, J; Jimenez, G; Antich, C; Peran, M; Baena, JM; Marchal, J.A.; Rus, G.

In-bioreactor ultrasonic monitoring of 3D culture human engineered cartilage

B-CHEMICAL SENSORS AND ACTUATORS, 2018;

FI: 5,667; D1

Gonzalez-Gonzalez, A; Munoz-Muela, E; Marchal, JA; Face, FE; Molina, MP; Cruz-Lozano, M; Jimenez, G; Verma, A; Ramirez, A; Qian, W; Chen, W; Kozielski, AJ; Element, O; Martin-Salvago, MD; Luque, RJ; Rosa-Garrido, C; Landeira, D; Quintana-Romero, M; Rosato, RR; Garcia, MA; Ramirez-Tortosa, CL; Kim, H; Rodriguez-Aguayo, C; Lopez-Berestein, G; Sood, AK; Lorente, JA; Sanchez-Rovira, P; Chang, JC; Granados-Principal, S

Activating Transcription Factor 4 Modulates TGF beta-Induced Aggressiveness in Triple-Negative Breast Cancer via SMAD2 / 3/4 and mTORC2 Signaling

CLINICAL CANCER RESEARCH, 2018;

FI: 10,199; D1

Jimenez, G; Hackenberg, M; Catherine, P; Boulaiz, H; Grinan-Lison, C; Garcia, MA; Peran, M; Lopez-Ruiz, E; Ramirez, A; Morata-Tarifa, C; Carrasco, E; Aguilera, M; Marchal, J.A.

Mesenchymal stem cell's secretome promotes selective enrichment of cancer stem-like cells with specific cytogenetic profile

CANCER LETTERS, 2018;

FI: 6,491; Q1

Galisteo-Gonzalez, F; Molina-Bolivar, J.A.; Navarro, SA; Boulaiz, H; Aguilera-Garrido, A; Ramirez, A; Marchal, J.A.

Albumin-covered lipid nanocapsules exhibit enhanced uptake performance by breast-tumor cells

COLLOIDS AND SURFACES B-BIOINTERFACES, 2018;

FI: 3,997; Q1

Picon-Ruiz, M; Morata-Tarifa, C; Valle-Goffin, JJ; Friedman, E.R.; Slingerland, J.M.

Obesity and Adverse Breast Cancer Risk and Outcome: Mechanistic Insights and Strategies for Intervention

CA-A CANCER JOURNAL FOR CLINICIANS, 2017;

FI: 187,04; D1

Kim, M; Jang, K; Miller, P; Picon-Ruiz, M; Yeasky, TM; El-Ashry, D; Slingerland, J.M.

VEGFA links self-renewal and metastasis by inducing Sox2 to repress miR-452, driving Slug

ONCOGENE, 2017;

FI: 7,519; D1

Garcia-Ortega, MB; Lopez, GJ; Jimenez, G; Garcia-Garcia, JA; Count, V; Boulaiz, H; Carrillo, E; Peran, M; Marchal, JA; Garcia, MA

Clinical and therapeutic potential of protein kinase PKR in cancer and metabolism

EXPERT REVIEWS IN MOLECULAR MEDICINE, 2017;

FI: 4,405; Q1

Lopez-Ruiz, E; Venkateswaran, S; Peran, M; Jimenez, G; Pernagallo, S; Diaz-Mochon, JJ; Tura-Ceide, O; Arrebola, F; Melchor, J; Soto, J; Rus, G; Royal, PJ; Diaz-Ricart, M; Count-Gonzalez, A; Bradley, M; Marchal, J.A.

Poly (ethylmethacrylate-co-diethylaminoethyl acrylate) coating improves endothelial repopulation, bio-mechanical and anti-thrombogenic properties of decellularized carotid arteries for blood vessel replacement

SCIENTIFIC REPORTS, 2017;

FI: 4,259; Q1

Morata-Tarifa, C; Picon-Ruiz, M; Grinan-Lison, C; Boulaiz, H; Peran, M; Garcia, MA; Marchal, J.A.

Validation of suitable normalizers for miR expression patterns analysis covering tumor heterogeneity

SCIENTIFIC REPORTS, 2017;

FI: 4,259; Q1

Navarro, SA; Carrillo, E; Grinan-Lison, C; Martina; Peran, M; Marchal, JA; Boulaiz, H

Cancer suicide gene therapy: a patent review

EXPERT OPINION ON THERAPEUTIC PATENTS, 2016;

FI: 4,626; D1

Picon-Ruiz, M; Bread, CD; Drews-Elger, K; Jang, K; Besser, A. H.; Zhao, D. K.; Morata-Tarifa, C; Kim, M; Ince, T. A.; Azzam, D.J.; Wander, SA; Wang, B; Ergonul, B; Datar, R.H.; Cote, R.J.; Howard, GA; El-Ashry, D; Torne-Poyatos, P; Marchal, J.A.; Slingerland, J.M.

Interactions between Adipocytes and Breast Cancer Cells Stimulate Cytokine Production and Drive Src / Sox2 / miR-302b-Mediated Malignant Progression

CANCER RESEARCH, 2016;

FI: 8,556; D1

Lopez-Ruiz, E; Jimenez, G; Garcia, MA; Antich, C; Boulaiz, H; Marchal, J.A.; Peran, M.

Polymers, scaffolds and bioactive molecules with therapeutic properties in osteochondral pathologies: what's new?

EXPERT OPINION ON THERAPEUTIC PATENTS, 2016;

FI: 4,626; D1

Venkateswaran, S; Luque-Gonzalez, MA; Tabraue-Chavez, M; Fara, MA; Lopez-Longarela, B; Cano-Cortes, V; Lopez-Delgado, FJ; Sanchez-Martin, R.M.; Ilyine, H; Bradley, M; Pernagallo, S; Diaz-Mochon, JJ

Novel bead-based platform for direct detection of unlabelled nucleic acids through Single Nucleobase Labeling

TALANTA, 2016;

FI: 4,035; Q1

Morata-Tarifa, C; Jimenez, G; Garcia, MA; Train, JM; Grinan-Lison, C; Aguilera, M; Picon-Ruiz, M; Marchal, JA

Low adherent cancer cell subpopulations are enriched in tumorigenic and metastatic epithelial-to-mesenchymal transition-induced cancer stem-like cells

SCIENTIFIC REPORTS, 2016;

FI: 5,228; Q1

Carrillo, E; Navarro, SA; Ramirez, A; Garcia, MA; Grinan-Lison, C; Peran, M; Marchal, J.A.

5-Fluorouracil derivatives: a patent review (2012-2014)

EXPERT OPINION ON THERAPEUTIC PATENTS, 2015;

FI: 4,297; D1

Jimenez, G; Lopez-Ruiz, E; Kwiatkowski, W; Montanez, E; Arrebola, F; Carrillo, E; Gray, PC; Belmonte, JCI; Choe, S; Peran, M; Marchal, J.A.

Activin A / BMP2 chimera AB235 drives efficient redifferentiation of long term cultured autologous chondrocytes

SCIENTIFIC REPORTS, 2015;

FI: 5,578; D1

Villatoro, MJPDY; Unciti-Broceta, JD; Contreras-Montoya, R; Garcia-Salcedo, J.A.; Mezo, MAG; Unciti-Broceta, A; Diaz-Mochon, JJ

Amide-controlled, one-pot synthesis of tri-substituted slurries generates structural diversity and analogues with trypanocidal activity

SCIENTIFIC REPORTS, 2015;

FI: 5,578; D1

Sanchez-Moreno, P; Mailbox, P; Boulaiz, H; Peula-Garcia, JM; Ortega-Vinuesa, JL; Luke, I; Salvati, A; Marchal, J.A.

Balancing the effect of corona on therapeutic efficacy and macrophage uptake of lipid nanocapsules

BIOMATERIALS, 2015;

FI: 8,557; D1

Roman, S; Agile, A; Peran, M; Alvaro-Galue, E; Ruiz-Ojeda, FJ; Fernandez-Vazquez, G; Marchal, J.A.

Brown adipose tissue and novel therapeutic approaches to treat metabolic disorders

TRANSLATIONAL RESEARCH, 2015;

FI: 5,03; D1

TF_2024-06 JA MARCHAL (TEC16)

Funder: FIBAO Foundation

File number: TF_2024-06

Execution time: 14/10/2024 - 31/12/2025

PI: JUAN ANTONIO MARCHAL CORRALES

Is the impact of plastic xenobiotics on childhood obesity and development irreversible? Functional role of the microbiota and its metabolites in the severity and chronicity of clinical effects.

Funder: CARLOS III HEALTH INSTITUTE - FEDER

File number: PI24 / 00046

Execution time: 01/01/2025 - 31/12/2027

PI: MARGARITA AGUILERA GOMEZ

Estrone's crucial role in the risk of developing ER+ breast cancer

Funder: CARLOS III HEALTH INSTITUTE - FEDER

File number: PI24 / 01797

Execution time: 01/01/2025 - 31/12/2027

IP: MANUEL PICON RUIZ

TF_2024-02 HOURIA BOULAIZ TASSI (TEC16)

Funder: FIBAO Foundation

File number: TF_2024-02

Execution time: 14/10/2024 - 31/12/2025

IP: HOURIA BOULAIZ TASSI

Personalized medicine through the application of targeted gene therapy to improve the diagnosis and treatment of Osteogenesis Imperfecta

Funder: MUTUA MADRILEÑA FOUNDATION

File number: FMM-AP16030-2024

Execution time: 01/07/2024 - 08/07/2027

IP: HOURIA BOULAIZ TASSI

Mass spectrometry-based proteomics to describe molecular mechanisms of congenital myasthenic syndromes (CMS) aiming the development of new therapies and the increase of effectiveness of current treatments.

Funder: HEALTH AND CONSUMPTION COUNCIL

File number: PI-0273-2024

Execution time: 28/11/2024 - 29/11/2027

IP: MARIA DEL CARMEN HERNANDEZ VALLADARES

Study of the prognostic and therapeutic value of the HSD17B family enzymes involved in estrone synthesis in patients with estrogen receptor-positive breast cancer

Funder: PUBLIC FOUNDATION FOR BIOSANITARY RESEARCH OF ORIENTAL ANDALUCIA ALEJANDRO OTERO (FIBAO)

File number: INTRAIBS-2022-07

Execution time: 20/01/2023 - 19/01/2024

IP: MANUEL PICON RUIZ

PROTEOMIC AND METABOLOMIC CHARACTERIZATION OF THE RESPONSE TO INTRAMUSCULAR INFUSION OF AUTOLOGOUS BONE MARROW STEM CELLS IN PATIENTS WITH AMYOTROPHIC LATERAL SCLEROSIS (ALS) FOR THE ESTABLISHMENT OF QUANTIFIABLE BIOMARKERS PREDICTIVE OF RESPONSE

Funder: UNIVERSITY OF GRANADA

File number: C-CTS-177-UGR23

Execution time: 01/01/2024 - 31/12/2026

IP: MARIA DEL CARMEN HERNANDEZ VALLADARES

Generation of a New Humanized Pompe Disease Model for Improved Robus Preclinical Evaluation of New Pompe Therapeutics

Funder: SPARK THERAPEUTICS, INC.

File number: SPARK-2022-0002

Execution time: 24/02/2023 - 24/02/2025

IP: FRANCISCO JAVIER MOLINA ESTEVEZ

Precision genetics to tackle pancreatic cancer chemoresistance

Funder: SPANISH ASSOCIATION AGAINST CANCER

File number: LABAE234749ZAFR

Execution time: 02/10/2023 - 01/10/2026

IP: MARIA PAZ DE LA ZAFRA MARTIN

Stem-Itruck: Next Generation Car-T Cells for the Safe and Effective Treatment of Solid Tumors

Funder: DEPARTMENT OF UNIVERSITY, RESEARCH AND INNOVATION

File number: ProyExcel_00373

Execution time: 01/01/2023 - 31/12/2025

IP: VERONICA AYLLON CASES

Generation of 4th generation inducible CAR-T cells for the treatment of HER2+ positive solid tumors.

Funder: CARLOS III HEALTH INSTITUTE - FEDER

File number: PMPTA22/00060

Execution time: 01/01/2023 - 31/12/2024

IP: FRANCISCO MARTIN MOLINA

Clinical impact of digital and 3D printed models based on CT and MRI fusion in pancreatic oncological surgery (DIGIPanCa)

Funder: STATE RESEARCH AGENCY

File number: TED2021-132438B-I00

Execution time: 01/12/2022 - 30/11/2024

PI: JUAN ANTONIO MARCHAL CORRALES

Spanish Network of Advanced Therapies (TERAV)

Funder: CARLOS III HEALTH INSTITUTE - FEDER

File number: RD21 / 0017/0004

Execution time: 01/01/2022 - 31/12/2024

IP: FRANCISCO MARTIN MOLINA

NABIHEAL – ANTIMICROBIAL NANOSTRUCTURED BIOMATERIALS FOR COMPLEX WOUND HEALING (NABIHEAL)

Funder: EUROPEAN COMMISSION

File number: 101092269

Execution time: 01/01/2023 - 31/12/2026

PI: JUAN ANTONIO MARCHAL CORRALES

Lymph and plasma extracellular vesicles as an alternative for the detection of mutations in breast cancer (BC-LinfaExOmic)

Funder: COUNCIL OF HEALTH AND FAMILIES

File number: PEMP-0205-2020

Execution time: 28/10/2021 - 27/10/2023

PI: JUAN ANTONIO MARCHAL CORRALES

Development and validation of a portable multimodular device for biomanufacturing and in situ repair of injured tissues (BioPen4Reg)

Funder: CARLOS III HEALTH INSTITUTE - FEDER

File number: DTS21 / 00098

Execution time: 01/01/2022 - 31/12/2023

PI: JUAN ANTONIO MARCHAL CORRALES

Development of decellularized biomimetic matrices with application in breast cancer models.

Funder: PUBLIC FOUNDATION FOR BIOSANITARY RESEARCH OF ORIENTAL ANDALUCIA ALEJANDRO OTERO (FIBAO)

File number: INTRAIBS-2020-10

Execution time: 01/01/2021 - 31/12/2021

IP: GEMA JIMENEZ GONZALEZ

HUMAN MICROBIOTA REFERENCE LABORATORY: Station for handling microorganisms in anaerobiosis and accessories for the optimization and harmonization of the phenotypic and genotypic analysis of the microbiota and its impact on nutrition and health.

Funder: COUNCIL OF ECONOMIC TRANSFORMATION, INDUSTRY, KNOWLEDGE AND UNIVERSITIES

File number: IE19_198 UGR

Execution time: 29/12/2020 - 29/12/2022

PI: MARGARITA AGUILERA GOMEZ

INFLUENCE OF ENDOCRINE DISRUPTERS CHEMICALS ON GUT MICROBIOTE: A MISSED LINK IN CHILDHOOD OBESITY (ENDOMICROMICS)

Funder: CARLOS III HEALTH INSTITUTE - FEDER

File number: PI20 / 01278

Execution time: 01/01/2021 - 31/12/2023

PI: MARGARITA AGUILERA GOMEZ

06-00001257-15 - FIPSE2015 - MARIA ANGEL GARCIA CHAVES - Method and means of isolation and enrichment of cancer stem cells with diagnostic and therapeutic utility in oncology

Funder: FOUNDATION FOR INNOVATION AND PROSPECTIVE IN HEALTH IN SPAIN

File number: 06-00001257-15

Execution time: 27/01/2016 - 26/07/2016

IP: MARIA ANGEL GARCIA CHAVES

Development of a Nanodiagnostic System Based on Myrnas / Exosomes Characteristic of Cancer Stem Cells with Prognostic and Predictive Value in Patients With Malignant Melanoma (Nanomir Melstem)

Funder: FUNDACION PUBLICA ANDALUZA PROGRESO Y SALUD

File number: PI-0533-2014

Execution time: 31/07/2015 - 01/08/2017

PI: JUAN ANTONIO MARCHAL CORRALES

PI-0441-2014 - Predictive Value of Pkr Kinase and Its Regulators in Patients With Metastatic Colon Cancer

Funder: FUNDACION PUBLICA ANDALUZA PROGRESO Y SALUD

File number: PI-0441-2014

Execution time: 01/08/2015 - 31/07/2017

IP: MARIA ANGEL GARCIA CHAVES

Drug development against tumor stem cells (CSCs) by screening synthetic libraries using GPCRs, kinases and the calcineurin-NFAT interaction as targets

Funder: MINISTRY OF ECONOMY AND COMPETITIVENESS

File number: RTC-2015-3386-1

Execution time: 01/09/2015 - 31/12/2017

PI: JUAN ANTONIO MARCHAL CORRALES

Prospective validation study of biomarkers of response to chemotherapy and therapies

Funder: CARLOS III HEALTH INSTITUTE - FEDER

File number: DTS15 / 00174

Execution time: 01/01/2016 - 31/12/2017

IP: MARIA ANGEL GARCIA CHAVES

Preclinical evaluation of safety and efficacy of a synthetic compound (MEGR756) and a compound of natural origin (MDN90) with selective activity against cancer stem cells

Funder: UNIVERSITY OF GRANADA

File number: UGR003 / B-16

Execution time: 01/01/2017 - 31/12/2018

PI: JUAN ANTONIO MARCHAL CORRALES

SMART OLIVE OIL NANOCAPSULES FOR ORAL ADMINISTRATION OF DRUGS AGAINST PANCREATIC CANCER STEM CELLS

Funder: MINISTRY OF ECONOMY AND COMPETITIVENESS

File number: MAT2015-63644-C2-2-R

Execution time: 01/01/2016 - 31/12/2018

PI: JUAN ANTONIO MARCHAL CORRALES

Potentiation of the action of ultrasound chemotherapy

Funder: UNIVERSITY OF GRANADA

File number: UGR002 / B-16

Execution time: 01/01/2017 - 31/12/2018

PI: JUAN ANTONIO MARCHAL CORRALES

HOKD TOXIN AS A NEW THERAPEUTIC TOOL AGAINST CANCER STEM CELLS DERIVED FROM PATIENTS WITH UTERAL CANCER

Funder: MUTUA MADRILEÑA FOUNDATION

File number: FMM-AP16683-2017

Execution time: 01/07/2017 - 31/12/2019

IP: HOURIA BOULAIZ TASSI

MUS4CT: Ultrasound Mechanotransduction for Improving Cancer Treatment

Funder: CARLOS III HEALTH INSTITUTE - FEDER

File number: DTS17 / 00087

Execution time: 01/01/2018 - 31/12/2019

PI: JUAN ANTONIO MARCHAL CORRALES

IMPLEMENTATION OF A NOVEL PLATFORM TO MONITOR TUMOR HETEROGENEITY AS A CRUCIAL DETERMINANT FOR INDIVIDUALIZED DIAGNOSTIC AND THERAPEUTIC OUTCOME

Funder: CARLOS III HEALTH INSTITUTE - FEDER

File number: PIE16 / 00045

Execution time: 01/01/2017 - 31/12/2019

PI: JUAN ANTONIO MARCHAL CORRALES

Development of bioprinting and biotin systems for three-dimensional cartilage and bone regeneration

Funder: MINISTRY OF ECONOMY AND COMPETITIVENESS

File number: RTC-2016-5451-1

Execution time: 01/01/2017 - 31/12/2019

PI: JUAN ANTONIO MARCHAL CORRALES

Development of a New Gene Therapy Tool Based on the Use of Ldrb Toxin Targeting Cancer Stem Cells Derived from Breast and Colon Cancer Patients.

Funder: COUNCIL OF HEALTH

File number: PI-0089-2017

Execution time: 01/01/2018 - 31/12/2020

IP: HOURIA BOULAIZ TASSI

BIOINKS 4 3D-SKIN: New biotinks for 3D bioprinting of skin grafts and malignant melanoma models

Funder: CARLOS III HEALTH INSTITUTE - FEDER

File number: DTS19 / 00143

Execution time: 01/01/2020 - 31/12/2021

PI: JUAN ANTONIO MARCHAL CORRALES

OBEMIRISK-Knowledge platform for assessing the risk of Biosphenols on gut microbiota and its role in obesogenic phenotype: looking for biomarkers,

Funder: EFSA EUROPEAN FOOD SAFETY AUTHORITY

File number: GP / EFSA / ENCO / 2018/03 - GA04

Execution time: 05/12/2018 - 01/05/2021

PI: MARGARITA AGUILERA GOMEZ

OncoBreast3DPrint: BIOPRINTED MIMETIC TUMOR MODELS OF BREAST CANCER USEFUL IN PRECISION ONCOLOGY

Funder: COUNCIL OF HEALTH AND FAMILIES

File number: PIN-0224-2019

Execution time: 01/01/2020 - 31/12/2022

IP: GEMA JIMENEZ GONZALEZ

IDENTIFICATION OF THE PATHOPHYSIOLOGICAL ROLE OF THE MICROBIOTA ALTERED BY DIETARY XENOBIOTICS IN PATIENTS WITH HORMONAL DISORDERS - REFERENCE LABORATORY

Funder: MINISTRY OF SCIENCE, INNOVATION AND UNIVERSITIES

File number: EIN2019-103082

Execution time: 01/11/2019 - 30/06/2021

PI: MARGARITA AGUILERA GOMEZ

RESEARCH INTENSIFICATION ACTIONS WITHIN THE EUROPEAN PROJECT: EFSA PARTNERING GRANT-GA04: OBEMIRISK

Funder: UNIVERSITY OF GRANADA

File number: INT-14

Execution time: 01/11/2019 - 30/06/2021

PI: MARGARITA AGUILERA GOMEZ

3D bioprinting of cartilage and bone with decellularized matrix-based biotin (dECM) for the regeneration of osteochondral lesions

Funder: MUTUA MADRILEÑA FOUNDATION

File number: FMM-AP17196-2019

Execution time: 01/07/2019 - 30/06/2022

PI: ELENA LOPEZ RUIZ

TEC16-Advanced Therapies: Differentiation, Regeneration and Cancer

Research lines

Research networks

Keywords

ALICIA RUIZ RODRIGUEZ

Ana Belen Diaz Ruano

Ana Voltes Martinez

Jesus Ruiz Espigares

Laura Garrido Martin

Elisa Nygren Jimenez

PAULA PLEGUEZUELOS BELTRAN

MARIA BELEN TOLEDO CUTILLAS

Jesus Pena Martin

LAURA DE LARA PEÑA

Julia Lopez de Andres

Alba Hidalgo Ramirez

NIEVES CASILLAS RUIZ

Giselle Xavier Reis

ANDREA MORENO REVUELTA

Maria Dolores Gomez Capel

AITOR GONZALEZ TITOS

MARIA DEL CARMEN HERNANDEZ VALLADARES

ALFONSO RUBIO NAVARRO

MARIA PAZ DE LA ZAFRA MARTIN

DANIEL NIETO GARCIA

PABLO GRAVAN JIMENEZ

JUAN ANTONIO MARCHAL CORRALES

SAUL ABENHAMAR NAVARRO MARCHAL

JOSE LUIS PALACIOS FERRER

ANTONIO PALOMEQUE JIMENEZ

MANUEL PICON RUIZ

GLORIA RUIZ ALCALA

FRANCISCO JESUS ​​ARREBOLA VARGAS

HOURIA BOULAIZ TASSI

ESMERALDA CARRILLO SLIM

MARIA EUGENIA GARCIA RUBIÑO

MARIA ANGEL GARCIA CHAVES

MICHAEL HACKENBERG

GEMA JIMENEZ GONZALEZ

ELENA LOPEZ RUIZ

MARGARITA AGUILERA GOMEZ

Research

FRANCISCO JESUS ARREBOLA VARGAS