TEC12-Maternal Fetal Health and Elastography
Advanced Therapies and Biomedical Technologies / IBS-TEC12 / Consolidated
The structural microarchitecture of soft tissue is recently becoming a cornerstone of biomechanical engineering and is of growing interest for a broad spectrum of clinical specialists. Our new ultrasonic wave concepts are enabling a new class of biomarkers for both imaging and controlling in vivo and noninvasively tissue microarchitecture. The breakthrough of modeling its elastic hierarchical complexity impacts critical aspects including organ-level functionality, inflammatory and healing processes, tumor growth, all the way down to cell-to-cell signaling. We have: a) Conceived and developed torsional ultrasonic waves and sensor technologies capable of generating and sensing them, prototyping robust functional instrumentation. b) Modeled relationships between the biochemical cascade and the mechanical functionality and their interaction with ultrasound, integrating models of tissue remodeling and tumor growth, experimentally validated by ultrasonication of cancer stem cells.
Research lines
- Biomechanics and mechanical tissue testing
- Sensorized bioreactors
- Ultrasound and elastography diagnostic medical devices - application to preterm delivery
- Elastographic and ultra-high speed ultrasound
- Statistical inference, artificial intelligence, forecast, decisions, image
- Biomechanical Computational Models - Finite Elements
Research networks
- Spanish Network for Research in Biomechanics
Keywords
Ultrasound, Ultrasound, Gynecology, Elastography, Biomechanics, Mechanical tests, Oncology, Waves, Bioreactors.
Maria Eugenia Velasco Garcia
ALEJANDRO CARMONA ZURFLUH
JOSE MANUEL CORTES CORTES
ANTONIA BELMONTE CARRILLO
ANDREA SAMPER GIRONA
ROCIO LOPEZ MARBLE
LAURA BAENA GARCIA
ANA MOLINA LOPEZ
ALIREZA ASHOFTEH YAZDI
YOUSEF ALMASHABEH SALEH
PARIS REZAEIAFARAPOLI
HIRAD SHAMI NOORI
OLGA OCON HERNANDEZ
MIGUEL ANGEL RIVEIRO TABOADA
GUILLERMO RUS CALBORG
JORGE PEREZ TORRES
BEATRIZ WHITE BESTEIRO
ANTONIO CALLEJAS ZAFRA
PILAR CARRETERO LUCENA
ANTONIO GOMEZ FERNANDEZ
OTILIA RUTH GONZALEZ VANEGAS
INAS H. FARIS
MANUEL HURTADO ESTEVEZ
JUAN MANUEL MELCHOR RODRIGUEZ
FRANCISCA SONIA MOLINA GARCIA
P201630123 - Procedure for obtaining data on the elasticity of materials using torsion waves
PCT / ES2016 / 070540 + P201500600 - Ultrasonic torsion wave emitting device and transducer that includes it.
P201730415 - Transluminal device and procedure for the mechanical characterization of structures.
Association between exposure to perfluoroalkyl substances (PFAS) and endometriosis in the ENDEA case-control study
Sci Total Environ, 2024;
FI: 8,2; D1
Validation of machine-learning model for first-trimester prediction of pre-eclampsia using cohort from PREVAL study
ULTRASOUND IN OBSTETRICS & GYNECOLOGY, 2024;
FI: 6,1; D1
Fetal Medicine Foundation charts for fetal growth in twins
ULTRASOUND IN OBSTETRICS & GYNECOLOGY, 2024;
FI: 6,1; D1
Comparison of different methods of first-trimester screening for preterm pre-eclampsia: cohort study
ULTRASOUND IN OBSTETRICS & GYNECOLOGY, 2024;
FI: 6,1; D1
Nipocalimab in Early-Onset Severe Hemolytic Disease of the Fetus and Newborn
NEW ENGLAND JOURNAL OF MEDICINE, 2024;
FI: 96,3; D1
Mechanotransduction in tumor dynamics modeling
PHYSICS OF LIFE REVIEWS, 2023;
FI: 11,7; D1
Cell cycle, apoptosis, cell differentiation, and lipid metabolism gene expression in endometriotic tissue and exposure to parabens and benzophenones
SCIENCE OF THE TOTAL ENVIRONMENT, 2023;
FI: 9,8; D1
Expression Profiles of Genes Related to Development and Progression of Endometriosis and Their Association with Paraben and Benzophenone Exposure
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023;
FI: 5,6; Q1
Effect of a Multimodal Supervised Therapeutic Exercise Program on Quality of Life, Pain, and Lumbopelvic Impairments in Women With Endometriosis Unresponsive to Conventional Therapy: A Randomized Controlled Trial
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION, 2023;
FI: 4,3; Q1
Optical micro-elastography with magnetic excitation for high frequency rheological characterization of soft media
ULTRASONICS, 2023;
FI: 4,2; Q1
Chondro-Inductive b-TPUe-Based Functionalized Scaffolds for Application in Cartilage Tissue Engineering.
ADVANCED HEALTHCARE MATERIALS, 2022;
FI: 11,092; D1
Lysozyme crystallization in hydrogel media under ultrasound irradiation
ULTRASONICS SONOCHEMISTRY, 2022;
FI: 9,336; D1
Preliminary Results on the Preinduction Cervix Status by Shear Wave Elastography
MATHEMATICS, 2022;
FI: 2,592; D1
Risk of fetal loss after chorionic villus sampling in twin pregnancy derived from propensity score matching analysis.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY, 2022;
FI: 8,678; D1
Associations between Sociodemographic Factors, Lifestyle Behaviors, Pregnancy-Related Determinants, and Mediterranean Diet Adherence among Pregnant Women: The GESTAFIT Project
NUTRIENTS, 2022;
FI: 6,706; Q1
Cosmetic and personal care product use, urinary levels of parabens and benzophenones, and risk of endometriosis: results from the EndEA study..
ENVIRONMENTAL RESEARCH, 2021;
FI: 6,498; D1
Early vaginal progesterone versus placebo in twin pregnancies for the prevention of spontaneous preterm birth: a randomized, double-blind trial
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 2021;
FI: 8,661; D1
Association of Self-Reported Physical Fitness during Late Pregnancy with Birth Outcomes and Oxytocin Administration during Labor-The GESTAFIT Project
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, 2021;
FI: 3,39; Q1
Association of Self-Reported Physical Fitness with Pregnancy Related Symptoms the GESTAFIT Project
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, 2021;
FI: 3,39; Q1
Braiding Thermoplastic and Glass Fibers in Dental Composite Post Improves Their Mechanical Compatibility, In Vitro Experiment
MATERIALS, 2021;
FI: 3,623; Q1
Association of Urinary Levels of Bisphenols A, F, and S with Endometriosis Risk: Preliminary Results of the EndEA Study
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, 2020;
Chronic Fatigue, Physical Impairments and Quality of Life in Women with Endometriosis: A Case-Control Study
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, 2020;
A Preliminary Study on the Safety of Elastography During Pregnancy: Hypoacusis, Anthropometry, and Apgar Score in Newborns
DIAGNOSTICS, 2020;
FI: 3,11; Q1
Characterization of non-linear mechanical behavior of the cornea
SCIENTIFIC REPORTS, 2020;
FI: 3,998; Q1
Association of objectively measured physical fitness during pregnancy with maternal and neonatal outcomes. The GESTAFIT Project
PLOSONE, 2020;
FI: 2,74; Q2
Bisphenol A and adiposity measures in peripubertal boys from the INMA-Granada cohort
ENVIRONMENTAL RESEARCH, 2019;
FI: 5,026; D1
Experimental Configuration to Determine the Nonlinear Parameter in PMMA and CFRP with the Finite Amplitude Method
SENSORS, 2019;
FI: 3,031; Q1
In Vivo Measurement of Cervical Elasticity on Pregnant Women by Torsional Wave Technique: A Preliminary Study
SENSORS, 2019;
FI: 3,031; Q1
Association of sedentary time and physical activity during pregnancy with maternal and neonatal birth outcomes. The GESTAFIT Project
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS, 2019;
FI: 3,631; Q1
Autism Spectrum Disorder (ASD) with and without Mental Regression Is Associated with Changes in the Fecal Microbiota
NUTRIENTS, 2019;
FI: 4,171; Q1
In-bioreactor ultrasonic monitoring of 3D culture human engineered cartilage
B-CHEMICAL SENSORS AND ACTUATORS, 2018;
FI: 5,667; D1
Prediction and prevention of small-for-gestational-age neonates: evidence from SPREE and ASPRE
ULTRASOUND IN OBSTETRICS & GYNECOLOGY, 2018;
FI: 5,654; D1
Screening for pre-eclampsia by maternal factors and biomarkers at 11-13 weeks' gestation
ULTRASOUND IN OBSTETRICS & GYNECOLOGY, 2018;
FI: 5,654; D1
Aspirin for Evidence-Based Preeclampsia Prevention trial: effect of aspirin on length of stay in the neonatal intensive care unit
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 2018;
FI: 5,732; D1
Logical Inference Framework for Experimental Design of Mechanical Characterization Procedures
SENSORS, 2018;
FI: 2,475; Q1
Safety of elastography in fetal medicine: preliminary study on hypoacusis
ULTRASOUND IN OBSTETRICS & GYNECOLOGY, 2017;
FI: 4,71; D1
Transient Elastography to Assess the Cervical Ripening During Pregnancy: A Preliminary Study
ULTRASCHALL IN DER MEDIZIN, 2017;
FI: 3,892; D1
Accuracy of competing-risks model in screening for pre-eclampsia by maternal factors and biomarkers at 11-13 weeks' gestation
ULTRASOUND IN OBSTETRICS & GYNECOLOGY, 2017;
FI: 4,71; D1
ASPRE trial: performance of screening for preterm pre-eclampsia
ULTRASOUND IN OBSTETRICS & GYNECOLOGY, 2017;
FI: 4,71; D1
Aspirin versus Placebo in Pregnancies at High Risk for Preterm Preeclampsia
NEW ENGLAND JOURNAL OF MEDICINE, 2017;
FI: 72,406; D1
Monochorionic diamniotic in vitro fertilization twins have a decreased incidence of twin-to-twin transfusion syndrome.
FERTILITY AND STERILITY, 2016;
FI: 4,426; D1
Cervical pessary placement for prevention of preterm birth in unselected twin pregnancies: a randomized controlled trial
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 2016;
FI: 4,681; D1
Three-dimensional ultrasonography for advanced neurosonography (Neurosofte-3d). Analysis of acquisition-related factors influencing the quality of the brain volumes
PRENATAL DIAGNOSIS, 2016;
FI: 3,043; Q1
Layered material characterization using ultrasonic transmission. An inverse estimation methodology
ULTRASONICS, 2016;
FI: 1,954; Q1
Maternal Body Weight and Gestational Diabetes Differentially Influence Placental and Pregnancy Outcomes
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2016;
FI: 5,531; Q1
Listen2Future – Acoustic sensor solutions integrated with digital technologies as key enablers for emerging applications fostering society 5.0
Funder: EUROPEAN COMMISSION
File number: 101096884
Execution time: 01/02/2023 - 31/01/2026
IP: GUILLERMO RUS CALBORG
In vivo viscoelastic biomarkers measurement of skin tumors is using torsional waves elastography (Skin-TWE)
Funder: PUBLIC FOUNDATION FOR BIOSANITARY RESEARCH OF ORIENTAL ANDALUCIA ALEJANDRO OTERO (FIBAO)
File number: INTRAIBS-2022-05
Execution time: 20/01/2023 - 19/01/2024
IP: INAS H FARIS
Impacting cancer cell microenvironment via mechanical waves to fight breast cancer and melanoma.
Funder: DEPARTMENT OF UNIVERSITY, RESEARCH AND INNOVATION
File number: ProyExcel_00182
Execution time: 01/01/2023 - 31/12/2025
IP: ANTONIO CALLEJAS ZAFRA
Viscoelastic biomarkers for thermometry of prostate cancer treatment using high-intensity focused ultrasound thermal ablation
Funder: UNIVERSITY OF GRANADA
File number: PPJIA2022-22
Execution time: 01/01/2023 - 31/12/2023
IP: ANTONIO GOMEZ FERNANDEZ
Acoustic sensor solutions integrated with digital technologies as key enablers for emerging applications fostering society 5.0
Funder: STATE RESEARCH AGENCY
File number: PCI2022-135048-2
Execution time: 31/12/2022 - 31/12/2025
IP: GUILLERMO RUS CALBORG
VALIDATION OF EARLY BIOCHEMISTRY IN THE UNIVERSAL SCREENING OF PREECLAMPSIA. PREMOM STUDIO
Funder: CARLOS III HEALTH INSTITUTE - FEDER
File number: PI21 / 00803
Execution time: 01/01/2021 - 31/12/2023
IP: OLGA OCON HERNANDEZ
Synthesis of Magnetoliposomes Containing Nanobubbles for Drug Delivery by Dual Remote Stimulation
Funder: STATE RESEARCH AGENCY
File number: PID2019-106947RA-C22
Execution time: 01/06/2020 - 31/05/2023
PI: JUAN MANUEL MELCHOR RODRIGUEZ
Mechanical wave prostate cancer diagnostic device.
Funder: PUBLIC FOUNDATION FOR BIOSANITARY RESEARCH OF ORIENTAL ANDALUCIA ALEJANDRO OTERO (FIBAO)
File number: INB-0010
Execution time: 10/06/2017 - 09/06/2019
IP: GUILLERMO RUS CALBORG
PI16 / 00339 PREDICTION OF LABOR BY ULTRASONIC ELASTOGRAPHY
Funder: CARLOS III HEALTH INSTITUTE - FEDER
File number: PI16 / 00339
Execution time: 01/01/2017 - 31/12/2019
PI: FRANCISCA SONIA MOLINA GARCIA
Torsion Ultrasounds for Preterm Labor Diagnosis and Prediction of Success in Induction.
Funder: COUNCIL OF HEALTH
File number: PI-0107-2017
Execution time: 01/01/2018 - 31/12/2020
PI: JUAN MANUEL MELCHOR RODRIGUEZ
Device for Prediction of Parturition Through the Technological Development of an Ultrasonic Torsion Sensor.
Funder: COUNCIL OF HEALTH
File number: PIN-0030-2017
Execution time: 01/01/2018 - 31/12/2020
IP: Device for Prediction of Parturition Through the Technological Development of an Ultrasonic Torque Sensor.
Impact of early detection and treatment of asymptomatic pregnant women with bacterial vaginosis on the preterm delivery rate (VB-PREM)
Funder: CARLOS III HEALTH INSTITUTE - FEDER
File number: PI17 / 01881
Execution time: 01/01/2018 - 31/12/2020
IP: OTILIA RUTH GONZALEZ VANEGAS
A phase IV, multicenter, open-label, single-arm study to evaluate the safety of almagate in pregnant women with heartburn and acidity, and perinatal outcomes in the fetus and newborn.
Financier: EVIDENZE HEALTH ESPAÑA, SLU
Type of test: CLINICAL TRIAL WITH DRUGS
Execution time: 07/11/2024 - 30/12/2027
IP: OLGA OCON HERNANDEZ
Use of Aspirin versus placebo in the prevention of preeclampsia in twin pregnancies: Randomized, multicenter, double-blind controlled study (ASPRE-T) (ASPRE TWINS)
Financier: FOUNDATION FOR HEALTH TRAINING AND RESEARCH OF THE REGION OF MURCIA
Type of test: CLINICAL TRIAL WITH DRUGS
Execution time: 15/11/2022 - 31/12/2025
IP: PILAR CARRETERO LUCENA
Development of a Preterm Labor Threat diagnostic algorithm that integrates clinical variables and the quantification of cervical consistency using the Fine Birth device
Funder: ULTRASOUND-INNOVATION MEDTECH, SL
Type of test: INV. CLINICA PRODUCT SANITARIO COM.
Execution time: 05/11/2020 - 30/06/2021
PI: FRANCISCA SONIA MOLINA GARCIA
