TEC03-Tissue Engineering
Advanced Therapies and Biomedical Technologies / IBS-TEC03 / Consolidated
Multidisciplinary group made up of doctors, histologists and tissue engineers, clinicians (surgeons, ophthalmologists, dentists, hematologists), biotechnologists, chemists, pharmacists, embryologists and those responsible for tissue banks. The group's objective is the generation and development of new models of artificial tissues for therapeutics. To do this, it develops innovative biomaterials and advanced techniques for cell selection and differentiation. The group also conducts preclinical tests prior to authorization by the Spanish Agency for Medicines and Health Products (AEMPS). In addition, it has transferred its own Advanced Therapies medications such as artificial cornea (currently in clinical trial - NCT01765244) and artificial skin (currently in use due to hospital exemption) to the clinic. The group advises the generation of drugs in the GMP rooms and histologically evaluates the Advanced Therapies drugs generated in them. On the other hand, it has 8 patents in different licensing phases.
Research lines
- Tissue Banks
- Biocompatible and biomimetic biomaterials
- Quality Control of Artificial Tissues
- Generation of Artificial Tissues
- Advanced Therapies
- Clinical transfer
Research networks
- EuroNanoMed3
- CTS115
- CTS580
- CTS974
- CA23140 - Boost and secure ATMP for BURN patient (ESENBURN)
Keywords
Artificial Tissues, Biomaterials, Cell Cultures, Advanced Therapies
MIGUEL ETAYO ESCANILLA
PAULA AVILA FERNANDEZ
FATIMA SANCHEZ AGUILERA
RACHEL OSORIO RUIZ
STAR OSORIO RUIZ
MANUEL TOLEDANO PEREZ
ARRABAL OLIMPIA ORTIZ
SALVADOR OYONARTE GOMEZ
MARIA CARMEN SANCHEZ QUEVEDO
DAVID SANCHEZ PORRAS
INDALECIO SANCHEZ-MONTESINOS GARCIA
ANTONIO CAMPOS MUÑOZ
VICTOR SEBASTIAN CARRIEL ARAYA
JESUS CHATO ASTRAIN
PASCUAL VICENTE CRESPO FERRER
RICARDO FERNANDEZ VALADES
JOSE MANUEL GARCIA LOPEZ
OSCAR DARIO GARCIA GARCIA
INGRID JOHANNA GARZON BELLO
CARMEN GONZALEZ GALLARDO
MIGUEL ANGEL MARTIN STONE
MIGUEL ALAMINOS MINGORANCE
FERNANDO CAMPOS SANCHEZ
Title: NERVE IMPLANTS BASED ON A COMPACTED BIOMATERIAL CONTAINING CELLS
Code: PCT / EP2012 / 072709
Inventors: Garzón Bello, Ingrid Johanna; Campos Munoz, Antonio; Gonzalez Andrades, Miguel; Alaminos Mingorance, Miguel; Munoz Avila, Jose Ignacio
Title: MANUFACTURE OF ARTIFICIAL TISSUES THROUGH TISSUE ENGINEERING USING BIOMATERIALS OF FIBRIN AND AGAROSE
Code: 80092JP01
Inventors: ANTONIO CAMPOS MUÑOZ, INGRID JOHANNA GARZON BELLO, JOSE IGNACIO MUÑOZ AVILA, MIGUEL ALAMINOS MINGORANCE, MIGUEL GONZÁLEZ ANDRADES, INGRID JOHANNA GARZÓN BELLO
Title: AGAROSE FIBRIN
Code: JP 2012-526090
Inventors: Garzón Bello, Ingrid Johanna; Campos Munoz, Antonio; Gonzalez Andrades, Miguel; Alaminos Mingorance, Miguel; Munoz Avila, Jose Ignacio
Title: MANUFACTURE OF ARTIFICIAL TISSUES THROUGH TISSUE ENGINEERING USING BIOMATERIALS OF FIBRIN AND AGAROSE
Code: EP10811319.2
Inventors: Garzón Bello, Ingrid Johanna; Campos Munoz, Antonio; Gonzalez Andrades, Miguel; Alaminos Mingorance, Miguel; Munoz Avila, Jose Ignacio
Title: MANUFACTURE OF ARTIFICIAL TISSUES THROUGH TISSUE ENGINEERING USING BIOMATERIALS OF FIBRIN AND AGAROSE
Code: US13 / 392.445
Inventors: Garrido Gomez, J; Gonzalez Andrades M; Alaminos Mingorance, M; Campos Munoz, A; Carriel Araya, A.
Title: NERVE IMPLANTS BASED ON A COMPACTED BIOMATERIAL CONTAINING CELLS
Code: EP11382349.6
Inventors: Garzón Bello, Ingrid Johanna; Campos Munoz, Antonio; Gonzalez Andrades, Miguel; Alaminos Mingorance, Miguel; Munoz Avila, Jose Ignacio
Title: MANUFACTURE OF ARTIFICIAL TISSUES THROUGH TISSUE ENGINEERING USING BIOMATERIALS OF FIBRIN AND AGAROSE.
Code: PCT / ES2010 / 070569
Inventors: Campos Munoz, Antonio; Alaminos Mingorance, Miguel; Hernandez Cortes, Pedro; Morales Villaescusa, Alvaro NO
Title: CHONDORITE MARKER SUSD2 (BIOMARKER OF HUMAN CARTILAGINE CELLS)
Code: P201030791
Inventors: Garzón Bello, Ingrid Johanna; Campos Munoz, Antonio; Gonzalez Andrades, Miguel; Alaminos Mingorance, Miguel; Munoz Avila, Jose Ignacio
Title: PREPARATION OF ARTIFICIAL TISSUES IN A MEDIUM WITH AGAROSE, FIBRIN AND COLLAGEN.
Code: P200930943
Inventors: Miguel Alaminos Mingorance; Jose Ignacio Munoz Avila; Miguel Gonzalez Andrades; Antonio Campos Munoz; Ingrid Johanna Garzon Bello
Title: Manufacture of artificial tissues by tissue engineering using fibrin, agarose and collagen biomaterials
Code: P200930943
Inventors: Garzón Bello, Ingrid Johanna; Campos Munoz, Antonio; Gonzalez Andrades, Miguel; Alaminos Mingorance, Miguel; Munoz Avila, Jose Ignacio
Title: MANUFACTURE OF ARTIFICIAL TISSUES THROUGH TISSUE ENGINEERING USING BIOMATERIALS OF FIBRIN AND AGAROSE.
Code: P200930625
Inventors: GARRIDO JIMENEZ JOSE MANUEL; SANCHEZ-MONTESINOS GARCIA INDALECIO
Title: COMPOSITION FOR THE PREVENTION OR TREATMENT OF PATHOLOGICAL PROCESSES RELATED TO ANGIOGENESIS AND CELLULAR PROLIFERATION
Code: P200930321
Effect of functionalized titanium particles with dexamethasone-loaded nanospheres on macrophage polarization and activity
DENTAL MATERIALS, 2024;
FI: 4,6; D1
Next-generation antibacterial nanopolymers for treating oral chronic inflammatory diseases of bacterial origin
INTERNATIONAL ENDODONTIC JOURNAL, 2024;
FI: 5,4; D1
Dentin remineralization using a stimuli-responsive engineered small molecule GSK3 antagonists-functionalized adhesive
DENTAL MATERIALS, 2024;
FI: 4,6; D1
Genipin crosslinking promotes biomechanical reinforcement and pro-regenerative macrophage polarization in bioartificial tubular substitutes
BIOMEDICINE & PHARMACOTHERAPY, 2024;
FI: 6,9; D1
Histological, histochemical, and immunohistochemical characterization of NANOULCOR nanostructured fibrin-agarose human cornea substitutes generated by tissue engineering
BMC MEDICINE, 2024;
FI: 7,1; D1
Histological characterization of the human masticatory oral mucosa. A histochemical and immunohistochemical study
MICROSCOPY RESEARCH AND TECHNIQUE, 2023;
FI: 2,5; Q1
Development of stromal differentiation patterns in heterotypical models of artificial corneas generated by tissue engineering
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, 2023;
FI: 5,7; Q1
Histological assessment of nanostructured fibrin-agarose skin substitutes grafted in burnt patients. A time-course study
BIOENGINEERING & TRANSLATIONAL MEDICINE, 2023;
FI: 7,4; Q1
Successful restoration of corneal surface integrity with a tissue-engineered allogeneic implant in severe keratitis patients
BIOMEDICINE & PHARMACOTHERAPY, 2023;
FI: 7,5; Q1
Peripheral nerve regeneration through nerve conduits evokes differential expression of growth-associated protein-43 in the spinal cord
NEURAL REGENERATION RESEARCH, 2023;
FI: 6,1; Q2
Biological Effects of Maslinic Acid on Human Epithelial Cells Used in Tissue Engineering
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, 2022;
FI: 6,064; Q1
Biomechanical Finite Element Method Model of the Proximal Carpal Row and Experimental validation..
FRONTIERS IN PHYSIOLOGY, 2022;
FI: 4,755; Q1
Extensor Pollicis Brevis Transosseous Tenodesis Technique for Treatment of Acquired Metacarpophalangeal Hyperextension Deformity of the Thumb: A Preliminary Report.
PLASTIC AND RECONSTRUCTIVE SURGERY, 2022;
FI: 5,169; Q1
Inactivation of human plasma alters the structure and biomechanical properties of engineered tissues
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, 2022;
FI: 6,064; Q1
Development of secretome-based strategies to improve cell culture protocols in tissue engineering
SCIENTIFIC REPORTS, 2022;
FI: 4,997; Q2
Comparison of Decellularization Protocols to Generate Peripheral Nerve Grafts: A Study on Rat Sciatic Nerves
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021;
FI: 5,924; Q1
Biofabrication of a Tubular Model of Human Urothelial Mucosa Using Human Wharton Jelly Mesenchymal Stromal Cells..
POLYMERS, 2021;
FI: 4,329; Q1
Effects of Sodium Chloride-Rich Mineral Water on Intestinal Epithelium. Experimental Study
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, 2021;
FI: 3,39; Q1
Evaluation of Marine Agarose Biomaterials for Tissue Engineering Applications
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021;
FI: 5,924; Q1
Basic Quality Controls Used in Skin Tissue Engineering.
LIFE-BASEL, 2021;
FI: 3,817; Q2
Evaluation of myopic cornea lenticules. A histochemical and clinical correlation
EXPERIMENTAL EYE RESEARCH, 2020;
FI: 3,011; Q1
Expanded Differentiation Capability of Human Wharton's Jelly Stem Cells Toward Pluripotency: A Systematic Review
TISSUE ENGINEERING PART B-REVIEWS, 2020;
FI: 6,089; Q1
Detergent-based decellularized peripheral nerve allografts: An in vivo preclinical study in the rat sciatic nerve injury model
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 2020;
FI: 3,078; Q2
Evaluation of Fibrin-Agarose Tissue-Like Hydrogels Biocompatibility for Tissue Engineering Applications
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, 2020;
FI: 3,644; Q2
Evaluation of the optical and biomechanical properties of bioengineered human skin generated with fibrin-agarose biomaterials
JOURNAL OF BIOMEDICAL OPTICS, 2020;
FI: 2,785; Q2
EFFECTIVE USE OF MESENCHYMAL STEM CELLS IN HUMAN SKIN SUBSTITUTES GENERATED BY TISSUE ENGINEERING
EUROPEAN CELLS & MATERIALS, 2019;
FI: 3,682; D1
Scleral surgical repair through the use of nanostructured fibrin / agarosebased films in rabbits
EXPERIMENTAL EYE RESEARCH, 2019;
FI: 2,998; Q1
Characterization of the human ridged and non-ridged skin: a comprehensive histological, histochemical and immunohistochemical analysis.
HISTOCEMISTRY AND CELL BIOLOGY, 2019;
FI: 2,64; Q1
Anisotropic magnetic hydrogels: design, structure and mechanical properties
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES, 2019;
FI: 3,093; Q1
Nanostructured fibrin agarose hydrogel as a novel haemostatic agent
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 2019;
FI: 3,319; Q2
Folliculitis decalvans: Effectiveness of therapies and prognostic factors in a multicenter series of 60 patients with long-term follow-up.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2018;
FI: 6,898; D1
Combination of melatonin and rapamycin for head and neck cancer therapy: Suppression of AKT / mTOR pathway activation, and activation of mitophagy and apoptosis via mitochondrial function regulation
JOURNAL OF PINEAL RESEARCH, 2018;
FI: 11,613; D1
Novel Desmin Mutation p.Glu401Asp Impairs Filament Formation, Disrupts Cell Membrane Integrity, and Causes Severe Arrhythmogenic Left Ventricular Cardiomyopathy / Dysplasia
CIRCULATION, 2018;
FI: 18,881; D1
Evaluation of freeze-drying and cryopreservation protocols for long-term storage of biomaterials based on decellularized intestine.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS, 2018;
FI: 3,373; Q1
Bioactive injectable aggregates with nanofibrous microspheres and human dental pulp stem cells: A translational strategy in dental endodontics
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 2018;
FI: 4,089; Q1
IL-10 overexpression predisposes to invasive aspergillosis by suppressing antifungal immunity
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2017;
FI: 13,081; D1
Controlling the 3D architecture of Self-Lifting Auto-generated Tissue Equivalents (SLATEs) for optimized corneal graft composition and stability
BIOMATERIALS, 2017;
FI: 8,402; D1
Differential expression of GAP-43 and neurofilament during peripheral nerve regeneration through bioartificial conduits.
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 2017;
FI: 3,989; Q1
In vitro characterization of a nanostructured fibrin agarose bio-artificial nerve substitute
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 2017;
FI: 3,989; Q1
Encapsulation of human elastic cartilage-derived chondrocytes in nanostructured fibrin-agarose hydrogels.
HISTOCEMISTRY AND CELL BIOLOGY, 2017;
FI: 2,553; Q1
Effect of the terminal group of phosphonate self-assembled films formed on Ti surfaces on the biomimetic layer formation and cell adhesion
APPLIED SURFACE SCIENCE, 2016;
FI: 3,15; D1
Trichoscopy of dissecting cellulitis of the scalp: Exclamation mark hairs and white dots as markers of disease chronicity
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2016;
FI: 5,621; D1
Clinical and trichoscopic characteristics of temporal triangular alopecia: A multicenter study
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2016;
FI: 5,621; D1
Deciphering the Lipid Architecture of the Rat Sciatic Nerve Using Imaging Mass Spectrometry
ACS CHEMICAL NEUROSCIENCE, 2016;
FI: 4,348; D1
Biocompatible magnetic core-shell nanocomposites for engineered magnetic tissues
NANOSCALE, 2016;
FI: 7,76; D1
Generation of a bioengineered autologous bone substitute for palate repair: an in vivo study in laboratory animals.
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 2015;
FI: 5,199; D1
In vitro characterization of a nanostructured fibrin agarose bio-artificial nerve substitute.
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 2015;
FI: 5,199; D1
Trichoscopic features of frontal fibrosing alopecia: Results in 249 patients
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2015;
FI: 4,449; D1
Effects of Four Formulations of Prostaglandin Analogs on Eye Surface Cells. A Comparative Study
PLOSONE, 2015;
FI: 3,234; Q1
Sequential keratinocytic differentiation and maturation in a three-dimensional model of human artificial oral mucosa.
JOURNAL OF PERIODONTAL RESEARCH, 2015;
FI: 2,466; Q1
Obtaining functionalized human oral mucosa substitutes with increased capabilities for the treatment of complex oral cavity pathologies
Funder: CARLOS III HEALTH INSTITUTE - FEDER
File number: PI24 / 00006
Execution time: 01/01/2025 - 31/12/2027
PI: INGRID JOHANNA GARZON BELLO
A multifunctional peptide-loaded nanopolymer for the treatment of peri-implantitis and periodontitis
Funder: STATE RESEARCH AGENCY
File number: PID2023-151623OB-I00
Execution time: 01/09/2024 - 31/12/2028
IP: RAQUEL OSORIO RUIZ
Preclinical characterization of novel bioartificial neural substitutes, generated by tissue engineering, for the repair of critical peripheral nerve injuries.
Funder: CARLOS III HEALTH INSTITUTE - FEDER
File number: PI23 / 00337
Execution time: 01/01/2024 - 31/12/2026
PI: VICTOR SEBASTIAN CARRIEL ARAYA
Optimization of human artificial skin models with improved physical and biological properties for use as advanced therapy products
Funder: UNIVERSITY OF GRANADA
File number: C-CTS-032-UGR23
Execution time: 01/01/2024 - 31/12/2026
IP: JESUS CHATO ASTRAIN
Fabrication and characterization of highly biomimetic human artificial corneas for regenerative treatment of corneal blindness
Funder: CARLOS III HEALTH INSTITUTE - FEDER
File number: PI23 / 00335
Execution time: 01/01/2024 - 31/12/2026
PI: MIGUEL ALAMINOS MINGORANCE
GENERATION OF A FULL THICKNESS SUBSTITUTE OF THE POTENTIAL HUMAN URETHRA
Funder: CARLOS III HEALTH INSTITUTE - FEDER
File number: PI22 / 00059
Execution time: 01/01/2023 - 31/12/2025
PI: RICARDO FERNANDEZ VALADES
NeuroFab – 4D manufacturing of grafts for the repair of neural tissue injuries.
Funder: STATE RESEARCH AGENCY
File number: CPP2021-009070
Execution time: 01/11/2022 - 31/10/2024
PI: VICTOR SEBASTIAN CARRIEL ARAYA
DEVELOPMENT OF AN IMPROVED MODEL; BIOMIMETIC AND POLYVANTING OF THE HUMAN ORAL MUCOSA AS SUBSTITUTE THERAPY IN ORAL SURGERY
Funder: CARLOS III HEALTH INSTITUTE - FEDER
File number: PI21 / 00980
Execution time: 01/01/2022 - 31/12/2024
PI: INGRID JOHANNA GARZON BELLO
Holoagar3D: functionalized biomaterial for bone regeneration
Funder: FOUNDATION FOR INNOVATION AND PROSPECTIVE IN HEALTH IN SPAIN
File number: FIPSE 3948-21
Execution time: 06/04/2021 - 05/10/2021
PI: MIGUEL ALAMINOS MINGORANCE
Clinical utility of a nanostructured fibrin-agarose artificial cornea model in patients with severe corneal ulcers (NANOULCOR)
Funder: Carlos III Health Institute - PRTR
File number: ICI21 / 00010
Execution time: 01/01/2022 - 31/12/2024
IP: CARMEN GONZALEZ GALLARDO
Design and generation by Tissue Engineering of a new model of polyvalent artificial dermis for its application to different skin regions as an advanced therapy drug.
Funder: PUBLIC FOUNDATION FOR BIOSANITARY RESEARCH OF ORIENTAL ANDALUCIA ALEJANDRO OTERO (FIBAO)
File number: INTRAIBS-2020-08
Execution time: 01/01/2021 - 31/12/2021
PI: FERNANDO CAMPOS SANCHEZ
Generation of new bioactive and functionalized artificial human corneas for clinical use as advanced therapy products.
Funder: CARLOS III HEALTH INSTITUTE - FEDER
File number: PI20 / 00317
Execution time: 01/01/2021 - 31/12/2023
PI: MIGUEL ALAMINOS MINGORANCE
Preclinical evaluation of a new peripheral nerve substitute generated by 3D bioprinting, decellularized hydrogels, and mesenquinial stem cells
Funder: CARLOS III HEALTH INSTITUTE - FEDER
File number: PI20 / 00318
Execution time: 01/01/2021 - 31/12/2023
PI: VICTOR SEBASTIAN CARRIEL ARAYA
Generation through tissue engineering of a bioartificial model of the sclerocorneal limbus for the treatment of limbic insufficiency
Funder: COUNCIL OF HEALTH AND FAMILIES
File number: PI-0086-2020
Execution time: 01/01/2021 - 31/12/2023
PI: MIGUEL ALAMINOS MINGORANCE
Preparation of Human Artificial Oral Mucosa as a Pharmaceutical Product for Advanced Therapies for Transfer to the Clinic
Funder: FUNDACION PUBLICA ANDALUZA PROGRESO Y SALUD
File number: PI-0386-2014
Execution time: 31/07/2015 - 30/09/2017
PI: INGRID JOHANNA GARZON BELLO
Generation and preclinical evaluation of a biomimetic model of human artificial oral mucosa
Funder: CARLOS III HEALTH INSTITUTE - FEDER
File number: PI15 / 02048
Execution time: 01/01/2016 - 31/12/2018
PI: MARIA CARMEN SANCHEZ QUEVEDO
Generation of Bio-Artificial Sclera Substitutes for Use as Advanced Therapy in Microsurgical Repair of the Eyeball
Funder: COUNCIL OF HEALTH
File number: PI-0400-2016
Execution time: 01/01/2017 - 31/12/2019
PI: INDALECIO SANCHEZ-MONTESINOS GARCIA
Manufacture of Bioactive Human Artificial Cartilage Through Tissue Engineering: Integrated Development of Chondrocytic Microspheres in Nanostructured Matrices
Funder: COUNCIL OF HEALTH
File number: PI-0257-2017
Execution time: 01/01/2018 - 31/12/2020
IP: Manufacture of Bioactive Human Artificial Cartilage Through Tissue Engineering: Integrated Development of Chondrocytic Microspheres in Nanostructured Matrices
Transversal tissue engineering and nanomedicine approach towards an improved chronic wound therapy
Funder: CARLOS III HEALTH INSTITUTE - FEDER
File number: AC17 / 00013
Execution time: 01/01/2018 - 31/12/2020
PI: MIGUEL ALAMINOS MINGORANCE
NanoGSkin - Transversal tissue engineering and nanomedicine approach towards an improved chronic wound therapy
Funder: CARLOS III HEALTH INSTITUTE - FEDER
File number: EURONANOMED III-2017-147
Execution time: 01/01/2018 - 31/12/2020
PI: MIGUEL ALAMINOS MINGORANCE
Generation and optimization of new artificial cornea models. Study compared to human artificial corneas implanted in a clinical trial.
Funder: CARLOS III HEALTH INSTITUTE - FEDER
File number: PI17 / 00391
Execution time: 01/01/2018 - 31/12/2020
PI: MIGUEL ALAMINOS MINGORANCE
Generation and evaluation of bioartificial substitutes for their use as advanced therapy in surgical repair of critical peripheral nerve injuries
Funder: CARLOS III HEALTH INSTITUTE - FEDER
File number: PI17 / 00393
Execution time: 01/01/2018 - 31/12/2020
PI: ANTONIO CAMPOS MUÑOZ
In vivo generation and evaluation of bio-artificial models of decellularized peripheral nerve with controlled structure and visco-elasticity
Funder: UNIVERSITY OF GRANADA
File number: A-CTS-498-UGR18
Execution time: 01/01/2020 - 31/12/2021
PI: ANTONIO CAMPOS MUÑOZ
Elaboration of a nanostructured artificial palate for its use in regenerative medicine for cleft palate
Funder: CARLOS III HEALTH INSTITUTE - FEDER
File number: PI18 / 00332
Execution time: 01/01/2019 - 31/12/2021
PI: RICARDO FERNANDEZ VALADES
Generation of new chewing and coating human oral mucosa models with functionalized biomaterials and alternative cell sources for use in advanced therapies
Funder: CARLOS III HEALTH INSTITUTE - FEDER
File number: PI18 / 00331
Execution time: 01/01/2019 - 31/12/2021
PI: INGRID JOHANNA GARZON BELLO
DEVELOPMENT OF A 3D BIOMIMETIC OSTEO-MUCOSUS SUBSTITUTE FOR THE TREATMENT OF SERIOUS DEFECTS OF THE ORAL CAVITY
Funder: COUNCIL OF HEALTH AND FAMILIES
File number: PI-0442-2019
Execution time: 01/01/2020 - 31/12/2022
IP: MIGUEL ANGEL MARTIN STONE
Regenerative medicine applied to traumatic peripheral nerve injuries. development of a new tissue-engineered drug for clinical use
Funder: MINISTRY OF ECONOMY, KNOWLEDGE, BUSINESSES AND UNIVERSITY
File number: P18-RT-5059
Execution time: 01/01/2020 - 31/12/2022
PI: VICTOR SEBASTIAN CARRIEL ARAYA
Fibrigar3D as a three-dimensional culture matrix
Funder: UNIVERSITY OF GRANADA
File number: PSETC_19_001
Execution time: 03/02/2020 - 03/02/2022
PI: INGRID JOHANNA GARZON BELLO
HUMAN PALATINE MUCOSA GENERATED THROUGH TISSUE ENGINEERING FOR THE TREATMENT OF PALATINE FISSURE (BIOCLEFT)
Funder: CARLOS III HEALTH INSTITUTE - FEDER
File number: ICI19 / 00024
Execution time: 01/01/2020 - 31/12/2023
PI: MIGUEL ALAMINOS MINGORANCE
GENERATION OF NEW MEDICALIZED SKIN MODELS FROM ARTIFICIAL FIBRIN-AGAROSE SKIN CLINICALLY TESTED IN LARGE BURN. FUNCTIONALIZATION WITH DRUGS AND NEW BIOFABRICATION PROCESSES
Funder: COUNCIL OF HEALTH AND FAMILIES
File number: PE-0383-2018
Execution time: 01/01/2019 - 31/12/2022
PI: MIGUEL ALAMINOS MINGORANCE
A phase I-IIa, randomized, controlled, open-label, single-center clinical trial to evaluate the safety, feasibility, and evidence of efficacy of using a tissue-engineered, nanostructured fibrin-agarose autologous human palatal mucosa substitute in the treatment of patients with cleft palate.
Funder: Alejandro Otero Foundation for Biosanitary Research of Eastern Andalusia (FIBAO)
Type of test: CLINICAL TRIAL WITH DRUGS
Execution time: 17/01/2024 - 30/01/2028
PI: RICARDO FERNANDEZ VALADES
Phase IIb, randomized, controlled, open-label, multicenter clinical trial to evaluate the clinical efficacy of a nanostructured fibrin-agarose artificial cornea model (NANOULCOR) in patients with severe corneal ulcers.
Funder: PUBLIC FOUNDATION FOR BIOSANITARY RESEARCH OF ORIENTAL ANDALUCIA ALEJANDRO OTERO (FIBAO)
Type of test: CLINICAL TRIAL WITH DRUGS
Execution time: 20/11/2023 - 30/09/2030
IP: CARMEN GONZALEZ GALLARDO
