TEC03-Tissue Engineering

Information
Members
Patents
Publications
Projects
Clinical trials

Multidisciplinary group made up of doctors, histologists and tissue engineers, clinicians (surgeons, ophthalmologists, dentists, hematologists), biotechnologists, chemists, pharmacists, embryologists and those responsible for tissue banks. The group's objective is the generation and development of new models of artificial tissues for therapeutics. To do this, it develops innovative biomaterials and advanced techniques for cell selection and differentiation. The group also conducts preclinical tests prior to authorization by the Spanish Agency for Medicines and Health Products (AEMPS). In addition, it has transferred its own Advanced Therapies medications such as artificial cornea (currently in clinical trial - NCT01765244) and artificial skin (currently in use due to hospital exemption) to the clinic. The group advises the generation of drugs in the GMP rooms and histologically evaluates the Advanced Therapies drugs generated in them. On the other hand, it has 8 patents in different licensing phases.

Research lines

Tissue Banks
Biocompatible and biomimetic biomaterials
Quality Control of Artificial Tissues
Generation of Artificial Tissues
Advanced Therapies
Clinical transfer

Research networks

EuroNanoMed3
CTS115
CTS580
CTS974
CA23140 - Boost and secure ATMP for BURN patient (ESENBURN)

Keywords

Artificial Tissues, Biomaterials, Cell Cultures, Advanced Therapies

STAR OSORIO RUIZ

MANUEL TOLEDANO PEREZ

ARRABAL OLIMPIA ORTIZ

SALVADOR OYONARTE GOMEZ

ORCID

MARIA CARMEN SANCHEZ QUEVEDO

ORCID

DAVID SANCHEZ PORRAS

INDALECIO SANCHEZ-MONTESINOS GARCIA

ORCID

ANTONIO CAMPOS MUÑOZ

VICTOR SEBASTIAN CARRIEL ARAYA

JESUS CHATO ASTRAIN

ORCID

PASCUAL VICENTE CRESPO FERRER

ORCID

CRISTINA WHITE ELICES

RICARDO FERNANDEZ VALADES

ORCID

JOSE MANUEL GARCIA LOPEZ

ORCID

OSCAR DARIO GARCIA GARCIA

ORCID

INGRID JOHANNA GARZON BELLO

ORCID

CARMEN GONZALEZ GALLARDO

ORCID

MIGUEL ANGEL MARTIN STONE

ORCID

MIGUEL ALAMINOS MINGORANCE

FERNANDO CAMPOS SANCHEZ

Inventors: Garrido Gomez, J; Gonzalez Andrades M; Alaminos Mingorance, M; Campos Munoz, A; Carriel Araya, A.
Degree: NERVE IMPLANTS BASED ON A COMPACTED BIOMATERIAL CONTAINING CELLS
Code: PCT / EP2012 / 072709

Inventors: Garzón Bello, Ingrid Johanna; Campos Munoz, Antonio; Gonzalez Andrades, Miguel; Alaminos Mingorance, Miguel; Munoz Avila, Jose Ignacio
Degree: MANUFACTURE OF ARTIFICIAL TISSUES THROUGH TISSUE ENGINEERING USING BIOMATERIALS OF FIBRIN AND AGAROSE
Code: 80092JP01

Inventors: ANTONIO CAMPOS MUÑOZ, INGRID JOHANNA GARZON BELLO, JOSE IGNACIO MUÑOZ AVILA, MIGUEL ALAMINOS MINGORANCE, MIGUEL GONZÁLEZ ANDRADES, INGRID JOHANNA GARZÓN BELLO
Degree: AGAROSE FIBRIN
Code: JP 2012-526090

Inventors: Campos Munoz, Antonio; Alaminos Mingorance, Miguel; Hernandez Cortes, Pedro; Morales Villaescusa, Alvaro NO
Degree: CHONDORITE MARKER SUSD2 (BIOMARKER OF HUMAN CARTILAGINE CELLS)
Code: P201030791

Inventors: Garzón Bello, Ingrid Johanna; Campos Munoz, Antonio; Gonzalez Andrades, Miguel; Alaminos Mingorance, Miguel; Munoz Avila, Jose Ignacio
Degree: PREPARATION OF ARTIFICIAL TISSUES IN A MEDIUM WITH AGAROSE, FIBRIN AND COLLAGEN.
Code: P200930943

Inventors: Miguel Alaminos Mingorance; Jose Ignacio Munoz Avila; Miguel Gonzalez Andrades; Antonio Campos Munoz; Ingrid Johanna Garzon Bello
Degree: Manufacture of artificial tissues by tissue engineering using fibrin, agarose and collagen biomaterials
Code: P200930943

Inventors: GARRIDO JIMENEZ JOSE MANUEL; SANCHEZ-MONTESINOS GARCIA INDALECIO
Degree: COMPOSITION FOR THE PREVENTION OR TREATMENT OF PATHOLOGICAL PROCESSES RELATED TO ANGIOGENESIS AND CELLULAR PROLIFERATION
Code: P200930321

Ibanez-Cortes, M; Martin-Piedra, MA; Garcia-Garcia, OD; Spain-Lopez, A; Fernandez-Valades, R; Sanchez-Quevedo, MD; Alaminos, M; Chato-Astrain, J; Garzon, I

Histological characterization of the human masticatory oral mucosa. A histochemical and immunohistochemical study

MICROSCOPY RESEARCH AND TECHNIQUE, 2023;

FI: 2,5; Q1

Blanco-Elices, C; Morales-Alvarez, C; Chato-Astrain, J; González-Gallardo, C; Avila-Fernández, P; Fields, F; Carmona, R; Martín-Piedra, MA; Garzón, I; Alaminos, M

Development of stromal differentiation patterns in heterotypical models of artificial corneas generated by tissue engineering

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, 2023;

FI: 5,7; Q1

Martin-Piedra, MA; Carmona, G; Campos, F; Carriel, V; Fernandez-Gonzalez, A; Campos, A; Cuende, N; Garzon, I; Gacto, P; Alaminos, M

Histological assessment of nanostructured fibrin-agarose skin substitutes grafted in burnt patients. A time-course study

BIOENGINEERING & TRANSLATIONAL MEDICINE, 2023;

FI: 7,4; Q1

González-Gallardo, C; Martínez-Atienza, J; Mataix, B; Muñoz-Avila, JI; Martínez-Rodríguez, JD; Medialdea, S; Ruiz-García, A; Lizana-Moreno, A; Arias-Santiago, S; Rosa-Fraile, MD; Garzon, I; Fields, A; Cuende, N; Alaminos, M; González-Andrades, M; Kill

Successful restoration of corneal surface integrity with a tissue-engineered allogeneic implant in severe keratitis patients

BIOMEDICINE & PHARMACOTHERAPY, 2023;

FI: 7,5; Q1

Chato-Astrain, J; Roda, O; Sanchez-Porras, D; Miralles, E; Alaminos, M; Fields, F; García-García, OD; Carriel, V

Peripheral nerve regeneration through nerve conduits evokes differential expression of growth-associated protein-43 in the spinal cord

NEURAL REGENERATION RESEARCH, 2023;

FI: 6,1; Q2

Ortiz-Arrabal, O; Chato-Astrain, J; Crespo, PV; Garzon, I; Mesa-Garcia, MD; Alaminos, M; Gomez-Llorente, C

Biological Effects of Maslinic Acid on Human Epithelial Cells Used in Tissue Engineering

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, 2022;

FI: 6,064; Q1

Marques, R; Melchior, J; Sanchez-Montesinos, I; Roda, O; Rus, G; Hernandez-Cortes, P

Biomechanical Finite Element Method Model of the Proximal Carpal Row and Experimental validation..

FRONTIERS IN PHYSIOLOGY, 2022;

FI: 4,755; Q1

Hernandez-Cortes, P; Hernandez-Peregrina, P; Pajares-Lopez, M; Cigna, E; Sanchez-Montesinos, I; Roda, O

Extensor Pollicis Brevis Transosseous Tenodesis Technique for Treatment of Acquired Metacarpophalangeal Hyperextension Deformity of the Thumb: A Preliminary Report.

PLASTIC AND RECONSTRUCTIVE SURGERY, 2022;

FI: 5,169; Q1

Rosell-Valle, C; Martin-Lopez, M; Fields, F; Chato-Astrain, J; Campos-Cuerva, R; Alaminos, M; Gonzalez, M.S.

Inactivation of human plasma alters the structure and biomechanical properties of engineered tissues

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, 2022;

FI: 6,064; Q1

Cases-Perera, O; Blanco-Elices, C; Chato-Astrain, J; Miranda-Fernandez, C; Fields, F; Crespo, PV; Sanchez-Montesinos, I; Alaminos, M; Martin-Piedra, MA; Garzon, I

Development of secretome-based strategies to improve cell culture protocols in tissue engineering

SCIENTIFIC REPORTS, 2022;

FI: 4,997; Q2

El Soury, M; Garcia-Garcia, D.O.; Moretti, M; Perroteau, I; Raimondo, S; Lovati, AB; Carriel, V.

Comparison of Decellularization Protocols to Generate Peripheral Nerve Grafts: A Study on Rat Sciatic Nerves

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021;

FI: 5,924; Q1

Garzón, I; Jaimes-Parra, BD; Pascual-Geler, M; Cozar, JM; Sanchez-Quevedo, MD; Mosquera-Pacheco, MA; Sanchez-Montesinos, I; Fernandez-Valades, R; Fields, F; Alaminos, M

Biofabrication of a Tubular Model of Human Urothelial Mucosa Using Human Wharton Jelly Mesenchymal Stromal Cells..

POLYMERS, 2021;

FI: 4,329; Q1

Crespo, PV; Fields, F; Loyal, M; Maraver, F.

Effects of Sodium Chloride-Rich Mineral Water on Intestinal Epithelium. Experimental Study

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, 2021;

FI: 3,39; Q1

Irastorza-Lorenzo, A; Sanchez-Porras, D; Ortiz-Arrabal, O; of Fruits, MJ; Stephen, E.; Fernandez, J.; Janer, A; Fields, A; Fields, F; Alaminos, M

Evaluation of Marine Agarose Biomaterials for Tissue Engineering Applications

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021;

FI: 5,924; Q1

Linares-González, L; Rodenas-Herranz, T; Fields, F; Ruiz-Villaverde, R; Carriel, V.

Basic Quality Controls Used in Skin Tissue Engineering.

LIFE-BASEL, 2021;

FI: 3,817; Q2

Rodriguez-Pozo, J.A.; Ramos-Lopez, JF; Gonzalez-Gallardo, MC; Fields, F; Sanchez-Porras, D; Oyonarte, S; Oruezabal, R.I.; Fields, A; Martin-Stone, MA; Alaminos, M.

Evaluation of myopic cornea lenticules. A histochemical and clinical correlation

EXPERIMENTAL EYE RESEARCH, 2020;

FI: 3,011; Q1

Garzon, I; Chato-Astrain, J; Campos, F; Fernandez-Valades, R; Sanchez-Montesinos, I; Campos, A; Alaminos, M; D'Souza, RN; Martin-Piedra, MA

Expanded Differentiation Capability of Human Wharton's Jelly Stem Cells Toward Pluripotency: A Systematic Review

TISSUE ENGINEERING PART B-REVIEWS, 2020;

FI: 6,089; Q1

Chato-Astrain, J; Phillips, C; Fields, F; Durand-Herrera, D; Garcia-Garcia, OD; Roosens, A; Alaminos, M; Fields, A; Carriel, V.

Detergent-based decellularized peripheral nerve allografts: An in vivo preclinical study in the rat sciatic nerve injury model

JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 2020;

FI: 3,078; Q2

Fields, F; Bonhome-Espinosa, AB; Chato-Astrain, J; Sanchez-Porras, D; Garcia-Garcia, OD; Carmona, R; Lopez-Lopez, MT; Alaminos, M; Carriel, V; Rodriguez, IA

Evaluation of Fibrin-Agarose Tissue-Like Hydrogels Biocompatibility for Tissue Engineering Applications

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, 2020;

FI: 3,644; Q2

Ionescu, AM; Chato-Astrain, J; Cardona, JD; Fields, F; Perez, M.M.; Alaminos, M; Garzón, I

Evaluation of the optical and biomechanical properties of bioengineered human skin generated with fibrin-agarose biomaterials

JOURNAL OF BIOMEDICAL OPTICS, 2020;

FI: 2,785; Q2

Martin-Stone, MA; Alfonso-Rodriguez, CA; Zapater, A; Durand-Herrera, D; Chato-Astrain, J; Fields, F; Sanchez-Quevedo, MC; Alaminos, M; Garzón, I

EFFECTIVE USE OF MESENCHYMAL STEM CELLS IN HUMAN SKIN SUBSTITUTES GENERATED BY TISSUE ENGINEERING

EUROPEAN CELLS & MATERIALS, 2019;

FI: 3,682; D1

Carriel, V; Vizcaino-Lopez, G; Chato-Astrain, J; Durand-Herrera, D; Alaminos, M; Fields, A; Sanchez-Montesinos, I; Fields, F.

Scleral surgical repair through the use of nanostructured fibrin / agarosebased films in rabbits

EXPERIMENTAL EYE RESEARCH, 2019;

FI: 2,998; Q1

Vela-Romera, A; Carriel, V; Martin-Stone, MA; Aneiros-Fernandez, J; Fields, F; Chato-Astrain, J; Prados-Olleta, N; Fields, A; Alaminos, M; Garzón, I

Characterization of the human ridged and non-ridged skin: a comprehensive histological, histochemical and immunohistochemical analysis.

HISTOCEMISTRY AND CELL BIOLOGY, 2019;

FI: 2,64; Q1

Gila-Vilchez, C; Manas-Torres, MC; Contreras-Montoya, R; Alaminos, M; Duran, JDG; from Cienfuegos, LA; Lopez-Lopez, MT

Anisotropic magnetic hydrogels: design, structure and mechanical properties

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES, 2019;

FI: 3,093; Q1

Campos-Cuerva, R; Fernandez-Munoz, B; Lopez, F.F.; Sands, SP; Santos-Gonzalez, M; Lopez-Navas, L; Alaminos, M; Fields, A; Muntane, J; Cepeda-Franco, C; Gomez-Bravo, MA

Nanostructured fibrin agarose hydrogel as a novel haemostatic agent

JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 2019;

FI: 3,319; Q2

Miguel-Gomez, L; Rodrigues-Barata, AR; Molina-Ruiz, A; Martorell-Calatayud, A; Fernandez-Crehuet, P; Grimalt, R; Boat, D; Arias-Santiago, S; Serrano-Falcon, C; Camacho, FM; Saceda-Corralo, D; Jaen-Olasolo, P; Vano-Galvan, S

Folliculitis decalvans: Effectiveness of therapies and prognostic factors in a multicenter series of 60 patients with long-term follow-up.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2018;

FI: 6,898; D1

Shen, YQ; Guerra-Librero, A; Fernandez-Gil, BI; Florido, J; Garcia-Lopez, S; Martinez-Ruiz, L; Mendivil-Perez, M; Soto-Mercado, V; Acuna-Castroviejo, D; Ortega-Arellano, H; Carriel, V; Diaz-Casado, ME; Reiter, RJ; Rusanova, I; Nieto, A; Lopez, LC; Scales, G

Combination of melatonin and rapamycin for head and neck cancer therapy: Suppression of AKT / mTOR pathway activation, and activation of mitophagy and apoptosis via mitochondrial function regulation

JOURNAL OF PINEAL RESEARCH, 2018;

FI: 11,613; D1

Bermudez-Jimenez, FJ; Carriel, V; Brodehl, A; Alaminos, M; Campos, A; Schirmer, I; Milting, H; April, BA; Alvarez, M; Lopez-Fernandez, S; Garcia-Giustiniani, D; Monserrat, L; Third, L; Jimenez-Jaimez, J

Novel Desmin Mutation p.Glu401Asp Impairs Filament Formation, Disrupts Cell Membrane Integrity, and Causes Severe Arrhythmogenic Left Ventricular Cardiomyopathy / Dysplasia

CIRCULATION, 2018;

FI: 18,881; D1

Diaz-Moreno, E; Durand-Herrera, D; Carriel, V; Martin-Stone, MA; Sanchez-Quevedo, MD; Garzón, I; Fields, A; Fernandez-Valades, R; Alaminos, M.

Evaluation of freeze-drying and cryopreservation protocols for long-term storage of biomaterials based on decellularized intestine.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS, 2018;

FI: 3,373; Q1

Garzon, I; Martin-Piedra, MA; Carriel, V; Alaminos, M; Liu, X; D'Souza, RN

Bioactive injectable aggregates with nanofibrous microspheres and human dental pulp stem cells: A translational strategy in dental endodontics

JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 2018;

FI: 4,089; Q1

Cunha, C; Goncalves, SM; Duarte-Oliveira, C; Leite, L; Lagrou, K; Marques, A. O.; Lupianez, C.B.; Mosque, I; Gaifem, J; Barbosa, AM; Vaz, C. P.; Branca, R; Campilho, F; Freitas, F; Light, D; Lass-Florl, C; Loffler, J; Jury, M; Saraiva, M; Kurzai, O; Rodrigues, F; Castro, AG; Wild, R; Sainz, J; Maertens, J.A.; Torrado, E; Jacobsen, I.D.; Lacerda, JF; Fields, A; Carvalho, A.

IL-10 overexpression predisposes to invasive aspergillosis by suppressing antifungal immunity

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2017;

FI: 13,081; D1

Gouveia, R.M.; Gonzalez-Andrades, E; Cardona, JC; Gonzalez-Gallardo, C; Ionescu, AM; Garzón, I; Alaminos, M; Gonzalez-Andrades, M; Connon, CJ

Controlling the 3D architecture of Self-Lifting Auto-generated Tissue Equivalents (SLATEs) for optimized corneal graft composition and stability

BIOMATERIALS, 2017;

FI: 8,402; D1

Carriel, V; Garzón, I; Fields, A; Cornelissen, M; Alaminos, M.

Differential expression of GAP-43 and neurofilament during peripheral nerve regeneration through bioartificial conduits.

JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 2017;

FI: 3,989; Q1

Carriel, V; Scionti, G; Fields, F; Rhodes, O; Castro, B; Cornelissen, M; Garzón, I; Alaminos, M.

In vitro characterization of a nanostructured fibrin agarose bio-artificial nerve substitute

JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 2017;

FI: 3,989; Q1

Garcia-Martinez, L; Fields, F; Godoy-Guzman, C; Sanchez-Quevedo, MD; Garzón, I; Alaminos, M; Fields, A; Carriel, V.

Encapsulation of human elastic cartilage-derived chondrocytes in nanostructured fibrin-agarose hydrogels.

HISTOCEMISTRY AND CELL BIOLOGY, 2017;

FI: 2,553; Q1

Sanchez-Trevino, A; Garcia-Martinez, O; Blasco-Avellaneda, D; Rodriguez-Valverde, MA; Luna-Bertos, E; Ramos-Torrecillas, J; Ruiz, C; Rosales-Leal, JI; Cabrerizo-Vilchez, MA

Effect of the terminal group of phosphonate self-assembled films formed on Ti surfaces on the biomimetic layer formation and cell adhesion

APPLIED SURFACE SCIENCE, 2016;

FI: 3,15; D1

Segurado-Miravalles, G; Camacho-Martinez, F; Arias-Santiago, S; Rodrigues-Barata, R; Serrano-Falcon, C; Moreno-Arrones, OM; Olasolo, PJ; Vano-Galvan, S.

Trichoscopy of dissecting cellulitis of the scalp: Exclamation mark hairs and white dots as markers of disease chronicity

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2016;

FI: 5,621; D1

Fernandez-Crehuet, P; Vano-Galvan, S; Martorell-Calatayud, A; Arias-Santiago, S; Grimalt, R.; Camacho-Martinez, FM

Clinical and trichoscopic characteristics of temporal triangular alopecia: A multicenter study

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2016;

FI: 5,621; D1

Fernandez, R; Carriel, V; Lage, S; Garate, J; Ten-Garcia, J; Ochoa, B; Castro, B; Alaminos, M; Fernandez, J.A.

Deciphering the Lipid Architecture of the Rat Sciatic Nerve Using Imaging Mass Spectrometry

ACS CHEMICAL NEUROSCIENCE, 2016;

FI: 4,348; D1

Rodriguez-Arco, L; Rodriguez, IA; Carriel, V; Bonhome-Espinosa, AB; Fields, F; Kuzhir, P; Duran, J.D.G.; Lopez-Lopez, MT

Biocompatible magnetic core-shell nanocomposites for engineered magnetic tissues

NANOSCALE, 2016;

FI: 7,76; D1

Liceras-Liceras E, Garzón I, Spain-López A, Oliveira AC, García-Gómez M, Martín-Piedra MÁ, Roda O, Alba-Tercedor J, Alaminos

Generation of a bioengineered autologous bone substitute for palate repair: an in vivo study in laboratory animals.

JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 2015;

FI: 5,199; D1

Carriel V, Scionti G, Campos F, Roda O, Castro B, Cornelissen M, Garzón I, Alaminos M

In vitro characterization of a nanostructured fibrin agarose bio-artificial nerve substitute.

JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 2015;

FI: 5,199; D1

Fernandez-Crehuet, P; Rodrigues-Barata, AR; Vano-Galvan, S; Serrano-Falcon, C; Molina-Ruiz, AM; Arias-Santiago, S; Martorell-Calatayud, A; Grimalt, R.; Garnacho-Saucedo, G; Serrano, S; Moreno, JC; Jaén, P; Camacho-Martinez, FM

Trichoscopic features of frontal fibrosing alopecia: Results in 249 patients

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2015;

FI: 4,449; D1

Perez-Roca, F; Rodrigo-Morales, E; Garzón, I; Oliveira, AC; Martin-Stone, MA; Carriel, V; Ortiz-Perez, AI; Sanchez-Montesinos, I; Fields, A; Alaminos, M.

Effects of Four Formulations of Prostaglandin Analogs on Eye Surface Cells. A Comparative Study

PLOSONE, 2015;

FI: 3,234; Q1

Vinuela-Prieto, JM; Sanchez-Quevedo, MC; Alfonso-Rodriguez, CA; Oliveira, AC; Scionti, G; Martin-Stone, MA; Moreu, G; Fields, A; Alaminos, M; Garzón, I

Sequential keratinocytic differentiation and maturation in a three-dimensional model of human artificial oral mucosa.

JOURNAL OF PERIODONTAL RESEARCH, 2015;

FI: 2,466; Q1

Preclinical characterization of novel bioartificial neural substitutes, generated by tissue engineering, for the repair of critical peripheral nerve injuries.

Funder: CARLOS III HEALTH INSTITUTE - FEDER

File number: PI23 / 00337

Execution time: 01/01/2024 - 31/12/2026

PI: VICTOR SEBASTIAN CARRIEL ARAYA

Optimization of human artificial skin models with improved physical and biological properties for use as advanced therapy products

Funder: UNIVERSITY OF GRANADA

File number: C-CTS-032-UGR23

Execution time: 01/01/2024 - 31/12/2026

IP: JESUS CHATO ASTRAIN

Fabrication and characterization of highly biomimetic human artificial corneas for regenerative treatment of corneal blindness

Funder: CARLOS III HEALTH INSTITUTE - FEDER

File number: PI23 / 00335

Execution time: 01/01/2024 - 31/12/2026

PI: MIGUEL ALAMINOS MINGORANCE

GENERATION OF A FULL THICKNESS SUBSTITUTE OF THE POTENTIAL HUMAN URETHRA

Funder: CARLOS III HEALTH INSTITUTE - FEDER

File number: PI22 / 00059

Execution time: 01/01/2023 - 31/12/2025

PI: RICARDO FERNANDEZ VALADES

NeuroFab – 4D manufacturing of grafts for the repair of neural tissue injuries.

Funder: STATE RESEARCH AGENCY

File number: CPP2021-009070

Execution time: 01/11/2022 - 31/10/2024

PI: VICTOR SEBASTIAN CARRIEL ARAYA

DEVELOPMENT OF AN IMPROVED MODEL; BIOMIMETIC AND POLYVANTING OF THE HUMAN ORAL MUCOSA AS SUBSTITUTE THERAPY IN ORAL SURGERY

Funder: CARLOS III HEALTH INSTITUTE - FEDER

File number: PI21 / 00980

Execution time: 01/01/2022 - 31/12/2024

PI: INGRID JOHANNA GARZON BELLO

Holoagar3D: functionalized biomaterial for bone regeneration

Funder: FOUNDATION FOR INNOVATION AND PROSPECTIVE IN HEALTH IN SPAIN

File number: FIPSE 3948-21

Execution time: 06/04/2021 - 05/10/2021

PI: MIGUEL ALAMINOS MINGORANCE

Clinical utility of a nanostructured fibrin-agarose artificial cornea model in patients with severe corneal ulcers (NANOULCOR)

Funder: CARLOS III HEALTH INSTITUTE - FEDER

File number: ICI21 / 00010

Execution time: 01/01/2022 - 31/12/2024

IP: CARMEN GONZALEZ GALLARDO

Design and generation by Tissue Engineering of a new model of polyvalent artificial dermis for its application to different skin regions as an advanced therapy drug.

Funder: PUBLIC FOUNDATION FOR BIOSANITARY RESEARCH OF ORIENTAL ANDALUCIA ALEJANDRO OTERO (FIBAO)

File number: INTRAIBS-2020-08

Execution time: 01/01/2021 - 31/12/2021

PI: FERNANDO CAMPOS SANCHEZ

Generation of new bioactive and functionalized artificial human corneas for clinical use as advanced therapy products.

Funder: CARLOS III HEALTH INSTITUTE - FEDER

File number: PI20 / 00317

Execution time: 01/01/2021 - 31/12/2023

PI: MIGUEL ALAMINOS MINGORANCE

Preclinical evaluation of a new peripheral nerve substitute generated by 3D bioprinting, decellularized hydrogels, and mesenquinial stem cells

Funder: CARLOS III HEALTH INSTITUTE - FEDER

File number: PI20 / 00318

Execution time: 01/01/2021 - 31/12/2023

PI: VICTOR SEBASTIAN CARRIEL ARAYA

Generation through tissue engineering of a bioartificial model of the sclerocorneal limbus for the treatment of limbic insufficiency

Funder: COUNCIL OF HEALTH AND FAMILIES

File number: PI-0086-2020

Execution time: 01/01/2021 - 31/12/2023

PI: MIGUEL ALAMINOS MINGORANCE

Preparation of Human Artificial Oral Mucosa as a Pharmaceutical Product for Advanced Therapies for Transfer to the Clinic

Funder: FUNDACION PUBLICA ANDALUZA PROGRESO Y SALUD

File number: PI-0386-2014

Execution time: 31/07/2015 - 30/09/2017

PI: INGRID JOHANNA GARZON BELLO

Generation and preclinical evaluation of a biomimetic model of human artificial oral mucosa

Funder: CARLOS III HEALTH INSTITUTE - FEDER

File number: PI15 / 02048

Execution time: 01/01/2016 - 31/12/2018

PI: MARIA CARMEN SANCHEZ QUEVEDO

Generation of Bio-Artificial Sclera Substitutes for Use as Advanced Therapy in Microsurgical Repair of the Eyeball

Funder: COUNCIL OF HEALTH

File number: PI-0400-2016

Execution time: 01/01/2017 - 31/12/2019

PI: INDALECIO SANCHEZ-MONTESINOS GARCIA

Manufacture of Bioactive Human Artificial Cartilage Through Tissue Engineering: Integrated Development of Chondrocytic Microspheres in Nanostructured Matrices

Funder: COUNCIL OF HEALTH

File number: PI-0257-2017

Execution time: 01/01/2018 - 31/12/2020

IP: Manufacture of Bioactive Human Artificial Cartilage Through Tissue Engineering: Integrated Development of Chondrocytic Microspheres in Nanostructured Matrices