TEC01-Safe Practice in the Use of Medicines
Advanced Therapies and Biomedical Technologies / IBS-TEC01
The group for the study of safe practices in the use of medicines was the result of the union of several professionals belonging to the University of Granada and the UGC of Pharmacy. It was established in 2009 to deepen the study of the chemical stability of drugs under conditions of clinical use, as well as to study the genetic variants that intervene and affect the efficacy, toxicity and dosage of drugs and their application to the daily clinical practice. In addition, it was determined to also influence the study and deepening of the health results of the use of drugs. The group, made up of professionals from the health care and academic fields, has achieved an upward projection, and through the application of new technologies contributes to the application of pharmacogenetics to daily clinical and therapeutic practice, contributing to scientific knowledge.
Research lines
- Pharmaceutical care and study of drug-related problems in different areas.
- Study of the stability of chemical and protein drugs under conditions of clinical use.
- Study of the practices that contribute to improving the safety of medications in clinical practice.
- Study of health results of the use of medicines.
- Study of genetic variants that affect the efficacy, toxicity or dosage of drugs.
- Drug utilization studies
Keywords
Pharmacogenetics, Safety in Drug Use, Drug Stability, Health Results.
EMILIO FERNANDEZ VARON
MARIA NUÑEZ NUÑEZ
ADELA MADRID WALLS
MARY IMMACULATE VALLEJO RODRIGUEZ
MARIA ANGELES GARCIA LIROLA
CELIA GOMEZ PEÑA
JESUS HERMOSILLA FERNANDEZ
ROCIO MORON ROMERO
NATALIA AFRICA NAVAS CHURCHES
RACHEL PEREZ ROBLES
LUIS MIGUEL SALMERON FEBRUARY
ANTONIO SALMERÓN GARCIA
ANABEL TORRENTE LOPEZ
SUSANA BELDA RUSTARAZO
DAVID BLANQUEZ MARTINEZ
JOSE HEAD BARRIER
FRANCISCO CASAS MALDONADO
LUIS TABLES RODRIGUEZ
XANDO DIAZ VILLAMARIN
Degree: PORTABLE IDENTIFICATION ELEMENT FOR A GOODS DISPENSING SYSTEM
Code: P201431867
Inventors: ANTONIO SALMERON GARCIA, JOSE CABEZA BARRERA, DANIEL ESCUDERO BROCAL, JAIME MATAS BUSTOS, JOSE MARÍA TUSET ARCAS
Degree: PUT LIGHT WIRELESS SYSTEM FOR FILLING DOSI TROLLEYS
Code: P201431559
Inventors: ANTONIO SALMERON GARCIA, JOSE CABEZA BARRERA, DANIEL ESCUDERO BROCAL, JAIME MATAS BUSTOS, JOSE MARÍA TUSET ARCAS
Degree: GOODS DISPENSATION SYSTEM
Code: P201431559
Comprehensive physicochemical characterization of a peptide-based medicine: Teduglutide (Revestive®) structural description and stress testing
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 2023;
FI: 4,9; Q1
Analyzing the In-Use Stability of mRNA-LNP COVID-19 Vaccines Comirnaty™ (Pfizer) and Spikevax™ (Moderna): A Comparative Study of the Particulate
VACCINES, 2023;
FI: 7,8; Q1
Azathioprine dose tailoring based on pharmacogenetic information: Insights from clinical implementation
BIOMEDICINE & PHARMACOTHERAPY, 2023;
FI: 7,5; Q1
QbD/PAT-State of the Art of Multivariate Methodologies in Food and Food-Related Biotech Industries
FOOD ENGINEERING REVIEWS, 2023;
FI: 6,6; Q1
Gut Microbiota Composition Can Predict Colonization by Multidrug-Resistant Bacteria in SARS-CoV-2 Patients in Intensive Care Unit: A Pilot Study
ANTIBIOTICS-BASEL, 2023;
FI: 4,8; Q2
Applications of multivariate data analysis in shelf life studies of edible vegetable oils – A review of the few past years
FOOD PACKAGING AND SHELF LIFE, 2022;
FI: 8,749; D1
Innovative and thorough practice to certify reference materials for sensory defects of olive oil
FOOD CHEMISTRY, 2022;
FI: 9,231; D1
Pharmacogenetics of siponimod: A systematic review
BIOMEDICINE & PHARMACOTHERAPY, 2022;
FI: 7,419; D1
Public healthcare costs associated with long-term exposure to mixtures of persistent organic pollutants in two areas of Southern Spain: A longitudinal analysis
ENVIRONMENTAL RESEARCH, 2022;
FI: 8,431; D1
Combined use of UV and MS data for ICH Stability-Indication Method: Quantification and isoforms identification of intact nivolumab
MICROCHEMICAL JOURNAL, 2022;
FI: 5,304; Q1
Chromatographic fingerprinting by comprehensive two-dimensional chromatography: Fundamentals and tools
TRAC TRENDS IN ANALYTICAL CHEMISTRY, 2021;
FI: 12,296; D1
Associations of residential and occupational history with the distribution of persistent pollutant mixtures in adipose tissue samples.-
ENVIRONMENTAL RESEARCH, 2021;
FI: 6,498; D1
Chromatographic Fingerprinting Enables Effective Discrimination and Identification of High-Quality Italian Extra-Virgin Olive Oils
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2021;
FI: 5,279; D1
Data mining/machine learning methods in foodomics
CURRENT OPINION IN FOOD SCIENCE, 2021;
FI: 6,031; D1
A Sensor-Based Methodology to Differentiate Pure and Mixed White Tequilas Based on Fused Infrared Spectra and Multivariate Data Treatment
CHEMOSENSORS, 2021;
FI: 3,398; Q2
A perfect tandem: chemometric methods and microfluidic colorimetric twin sensors on paper. Beyond the traditional analytical approach
MICROCHEMICAL JOURNAL, 2020;
FI: 3,594; Q1
Authentication of the geographical origin and the botanical variety of avocados using liquid chromatography fingerprinting and deep learning methods
CHEMOMETRICS AND INTELLIGENT LABORATORY SYSTEMS, 2020;
FI: 2,895; Q1
Comprehensive biophysical and functional study of ziv-aflibercept: characterization and forced degradation
SCIENTIFIC REPORTS, 2020;
FI: 3,998; Q1
Comparing different domains of analysis for the characterization of N-glycans on monoclonal antibodies
JOURNAL OF PHARMACEUTICAL ANALYSIS, 2020;
FI: 2,673; Q3
Dalbavancin is a novel antimicrobial against Gram-positive pathogens: clinical experience beyond labeled indications
EUROPEAN JOURNAL OF HOSPITAL PHARMACY-SCIENCE AND PRACTICE, 2020;
FI: 0,892; Q4
Comparative Stability Studies of Different Infliximab and Biosimilar CT-P13 Clinical Solutions by Combined Use of Physicochemical Analytical Techniques and Enzyme-Linked Immunosorbent Assay (ELISA)
BIODRUGS, 2019;
FI: 4,903; D1
Impact of single nucleotide polymorphisms on the efficacy and toxicity of EGFR tyrosine kinase inhibitors in advanced non-small cell lung cancer patients.
MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH, 2019;
FI: 6,081; D1
The Importance of the Microbiome in Critically Ill Patients: Role of Nutrition
NUTRIENTS, 2019;
FI: 4,171; Q1
Pharmacogenetics in the Treatment of Cardiovascular Diseases and Its Current Progress Regarding Implementation in the Clinical Routine
GENES, 2019;
FI: 3,331; Q2
Cost-effectiveness analysis of pharmacogenomics-guided clopidogrel treatment in Spanish patients undergoing percutaneous coronary intervention.
PHARMACOGENOMICS JOURNAL, 2019;
FI: 3,503; Q2
Solver, an Excel application to solve the difficulty in applying different univariate linear regression methods
CHEMOMETRICS AND INTELLIGENT LABORATORY SYSTEMS, 2018;
FI: 2,701; D1
Multivariate approaches for stability control of the olive oil reference materials for sensory analysis-part II: applications
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE, 2018;
FI: 2,379; Q1
Multivariate approaches for stability control of the olive oil reference materials for sensory analysis-part I: framework and fundamentals
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE, 2018;
FI: 2,379; Q1
Validated reverse phase HPLC diode array method for the quantification of intact bevacizumab, infliximab and trastuzumab for long-term stability study
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECLES, 2018;
FI: 3,909; Q1
Study of aggregation in therapeutic monoclonal antibodies subjected to stress and long-term stability tests by analyzing size exclusion liquid chromatographic profiles.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECLES, 2018;
FI: 3,909; Q1
One input-class and two input-class classifications for differentiating olive oil from other edible vegetable oils by use of the normal-phase liquid chromatography fingerprint of the methyl-transesterified fraction
FOOD CHEMISTRY, 2017;
FI: 4,529; D1
Method for the comparison of complex matrix assisted laser desorption ionization-time of flight mass spectra. Stability of therapeutic monoclonal antibodies
CHEMOMETRICS AND INTELLIGENT LABORATORY SYSTEMS, 2017;
FI: 2,303; D1
Pigment-size effect on the physico-chemical behavior of azurite-tempera dosimeters upon natural and accelerated photo aging
DYES AND PIGMENTS, 2017;
FI: 3,473; D1
Principal Component Analysis to interpret changes in chromatic parameters on paint dosimeters exposed long-term to urban air
CHEMOMETRICS AND INTELLIGENT LABORATORY SYSTEMS, 2017;
FI: 2,303; D1
Implementing Pharmacogenomics in Europe: Design and Implementation Strategy of the Ubiquitous Pharmacogenomics Consortium
CLINICAL PHARMACOLOGY & THERAPEUTICS, 2017;
FI: 7,266; D1
Combined untargeted and targeted fingerprinting with comprehensive two-dimensional chromatography for volatiles and ripening indicators in olive oil.
CHEMICAL ANALYTICS ACTA, 2016;
FI: 4,712; D1
Quality performance metrics in multivariate classification methods for qualitative analysis
TRAC TRENDS IN ANALYTICAL CHEMISTRY, 2016;
FI: 7,487; D1
Chromatographic fingerprinting: An innovative approach for food 'identitation' and food authentication - A tutorial
CHEMICAL ANALYTICS ACTA, 2016;
FI: 4,712; D1
Authentication of canned fish packing oils by means of Fourier transform infrared spectroscopy
FOOD CHEMISTRY, 2016;
FI: 4,052; D1
Results of genotype-guided antiplatelet therapy in patients who undergo percutaneous coronary intervention with stent
INTERNATIONAL JOURNAL OF CARDIOLOGY, 2016;
FI: 4,638; Q1
Triacylglycerols Determination by High-temperature Gas Chromatography in the Analysis of Vegetable Oils and Foods: A Review of the Past 10 Years
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION, 2015;
FI: 5,176; D1
Cluster-based comparison of the peptide mass fingerprint obtained by MALDI-TOF mass spectrometry. A case study: long-term stability of rituximab
ANALYST, 2015;
FI: 4,107; D1
Seasonal occurrence and distribution of a group of ECs in the water resources of Granada city metropolitan areas (South of Spain): Pollution of raw drinking water
JOURNAL OF HYDROLOGY, 2015;
FI: 3,053; D1
Comparative analysis of monoclonal antibody N-glycosylation using stable isotope labeling and UPLC-fluorescence-MS
ANALYST, 2015;
FI: 4,107; D1
Quantitative Host Cell Protein Analysis Using Two Dimensional Data Independent LC-MSE
ANALYTICAL CHEMISTRY, 2015;
FI: 5,636; D1
Automated Instrument for the Assessment of Antimicrobial Use and Resistance (AI-AMS)
Funder: STATE RESEARCH AGENCY
File number: CPP2022-009977
Execution time: 01/05/2023 - 31/12/2025
IP: MARIA NUÑEZ NUÑEZ
PROA-HUCSC: Development and integration of an intelligent tool to support Antimicrobial Use Optimization Programs (PROA)
Funder: ANDALUSIAN HOSPITAL PHARMACY FOUNDATION
File number: FAFH23-001
Execution time: 01/06/2023 - 31/05/2025
IP: MARIA IMMACULADA VALLEJO RODRIGUEZ
Development of ad-hoc advanced analytical strategies for comprehensive studies of protein biotechnological drugs in hospital settings: stability in prefilled syringes and impact of stability on telepharmacy programs
Funder: UNIVERSITY OF GRANADA
File number: C-EXP-277-UGR23
Execution time: 01/01/2024 - 31/12/2026
IP: ANTONIO SALMERON GARCIA
Stability studies over time of leftover biotechnological drugs -monoclonal antibodies and fusion proteins-. Comprehensive conformational studies.
Funder: CARLOS III HEALTH INSTITUTE - FEDER
File number: PI17 / 00547
Execution time: 01/01/2018 - 31/12/2020
PI: NATALIA AFRICA NAVAS IGLESIAS
UPGX - Making actionable pharmacogenomic data and effective treatment optimization accessible to every European citizen
Funder: EUROPEAN COMMISSION
File number: PHC2015-668353
Execution time: 01/01/2016 - 31/12/2020
IP: CRISTINA LUCIA DAVILA FAJARDO
Development of a decision algorithm that assesses the risk of new cardiovascular events using NGS technology to determine the response to antiplatelet agents in ACS patients undergoing PCI with stent implantation:
Funder: PUBLIC FOUNDATION FOR BIOSANITARY RESEARCH OF ORIENTAL ANDALUCIA ALEJANDRO OTERO (FIBAO)
File number: PE-0413-2018
Execution time: 01/01/2019 - 31/12/2022
IP: CRISTINA LUCIA DAVILA FAJARDO
Postmarketing Follow-up Clinical Study in Patients With Thoracoabdominal Aortic Aneurysms Treated With the E-nside TAAA Multi-Branch Stent Graft System
Financier: JOTEC GMBH
Type of test: INV. CLINICA PRODUCT SANITARIO COM.
Execution time: 28/01/2022 - 30/06/2031
PI: LUIS MIGUEL SALMERON FEBRES
Real-Life Data Collection of the GORE® VIABAHN® VBX Balloon-Expandable Endoprosthesis When Used as a Bridging Stent with Branched and Fenestrated Endoprostheses for the Treatment of Aortic Aneurysms Involving the Renal-Mesenteric Arteries
Funder: WL GORE & ASSOCIATES, INC.
Type of test: INV. CLINICA PRODUCT SANITARIO COM.
Execution time: 07/02/2022 - 31/12/2026
PI: LUIS MIGUEL SALMERON FEBRES
Retrospective Post-Marketing Follow-Up Clinical Study of GORE-TEX® Vascular Grafts and GORE® PROPATEN® Vascular Graft in Peripheral Artery Disease, Aortic Aneurysms, and Dialysis Access.
Funder: WL GORE & ASSOCIATES, INC.
Type of test: INV. CLINICA PRODUCT SANITARIO COM.
Execution time: 08/10/2021 - 31/12/2022
PI: LUIS MIGUEL SALMERON FEBRES
Phase I Open-label, First-in-human Study to Evaluate Feasibility and Safety of Tissue Engineered Veins in Patients With Chronic Venous Insufficiency
Funder: FUNDACION PUBLICA ANDALUZA PROGRESO Y SALUD
Type of test: COMMERCIAL CLINICAL TRIAL
Execution time: 09/09/2021 - 30/12/2023
PI: LUIS MIGUEL SALMERON FEBRES
VenaSeal Spectrum: Global, Post-Market, Prospective, Multi-Center, Randomized Controlled Trial of the VenaSeal ™ Closure System vs. Surgical Stripping or Endothermal Ablation (ETA) for the Treatment of Early and Advanced Stage Superficial Venous Disease
Funder: MEDTRONIC BAKKEN RESEARCH CENTER BV
Type of test: INV. CLINICA PRODUCT SANITARIO COM.
Execution time: 09/11/2020 - 28/02/2027
PI: LUIS MIGUEL SALMERON FEBRES
Clinical study to evaluate the safety, efficacy, resource utilization and costs associated with the use of the GORE® TAG® Adaptive Thoracic Stent Graft with ACTIVE CONTROL System for patients with descending thoracic aortic pathologies
Funder: ENDOVASCULAR FOUNDATION
Type of test: INV. INDEP SANITARY PRODUCT CLINIC.
Execution time: 06/07/2020 - 30/12/2024
PI: LUIS MIGUEL SALMERON FEBRES
Retrospective observational study to characterize and evaluate the clinical results of patients who received Benralizumab after its marketing approval in Spain. (ORB STUDY II)
Funder: ASTRAZENECA FARMACEUTICA ESPAÑA SA
Type of test: COMMERCIAL POST AUTHORIZATION STUDY
Execution time: 03/11/2020 - 30/06/2021
PI: FRANCISCO CASAS MALDONADO
Observational study to evaluate the clinical management and the adequacy of the therapeutic strategies used in patients with stable atherosclerotic disease and the use of recommended treatments according to clinical guidelines. APALUSE STUDY
Funder: CASA DEL CORAZON FOUNDATION
Type of test: INDEPENDENT POST-AUTHORIZATION STUDY
Execution time: 17/01/2020 - 30/09/2020
PI: LUIS MIGUEL SALMERON FEBRES
