MPE05-Translational Research in Cardiovascular Diseases

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Members
Publications
Projects
Clinical trials

A group of professionals, mostly from the field of cardiology, who base their research work on the study of cardiac pathologies, their etiology, development and updating of treatment alternatives.

Research lines

Cachexia and nutrition in patients with HF and LV systolic dysfunction
Nursing health education for patients with HF (secondary prevention).
Effect of hisian pacing on pacing-induced cardiomyopathy.
Effect of physical exercise on arrhythmic risk in patients with arrhythmogenic cardiomyopathy.
Cardiovascular pharmacogenetics
Iron deficiency in patients with HF and LV systolic dysfunction.
Genetics of sudden cardiac death and inherited heart diseases.
Multidisciplinary management of CI.
Pulmonary hypertension after mitral valve surgery.
Impact of psychological factors in Acute Coronary Syndromes: Incidence, pathophysiological mechanisms and intervention procedures.
Influence of the Mediterranean diet in recurrences of atrial fibrillation.
Sudden cardiac death in adult patients with congenital heart disease.
Navigation without scope for ablation of cardiac arrhythmias.
Clinical and echocardiographic parameters that determine the indication and type of repair in tricuspid regurgitation.
Mortality patterns and readmissions in patients with HF.
PRISMA Project: Spanish reference center for training in CI Units

DIEGO GINES SEGURA RODRIGUEZ

RICARDO FRANCISCO RIVERA LOPEZ

FRANCISCO JOSE BERMUDEZ JIMENEZ

ORCID

MARIA BELEN GARCIA ORTEGA

ORCID

JOAQUIN SANCHEZ GILA

PABLO SANCHEZ MILLAN

LUIS THIRD SANCHEZ

ORCID

EDUARDO MOLINA NAVARRO

JUAN KNIGHT BORREGO

ROCIO GARCIA ORTA

ORCID

JUAN JIMENEZ JAIMEZ

ORCID

MIRIAM JIMENEZ FERNANDEZ

ORCID

MANUEL LOPEZ PEREZ

SILVIA LOPEZ FERNANDEZ

ORCID

ROSE MACIAS RUIZ

ORCID

MIGUEL ALVAREZ LOPEZ

ANTONIO LUIS ARREBOLA MORENO

ORCID

Garzon-Furne, AI; Ferreiro-Marzala, A; Rodriguez-Serrano, F; Esteban-Molina, M; Garcia-Orta, R; Moreno-Escobar, E; Garcia-Delgado, M; Sevilla-Martinez, M; Gomez-Luque, JM; Ocete-Hita, E; Rodríguez-Vázquez del Rey, MD; Nuila-Durán, LM; Garrido, J.M.

Valve repair in mitral endocarditis

CARDIOVASCULAR SURGERY, 2023;

Sola-García, E; Molina-Lerma, M; Jiménez-Jáimez, J; Macías-Ruiz, R; Sánchez-Millán, PJ; Third, L; Alvarez, M.

Autothreshold algorithm feasibility and safety in left bundle branch pacing

EUROPACE, 2023;

FI: 6,1; Q1

Molina-Lerma, M; Cabrera-Borrego, E; Rivera-Lopez, R; Sánchez-Millán, P; Mellado, J; Jiménez, A; Alvarez, M.

Comparison of automated subcutaneous defibrillator screening between different pacing sites in cardiac pacing device carriers

EUROPACE, 2023;

FI: 6,1; Q1

Bermudez-Jimenez, F; Carriel, V; Santos-Mateo, JJ; Fernandez, A; Garcia-Hernandez, S; Ramos, KA; Piqueras-Flores, J; Cabrera-Romero, E; Barriales-Villa, R; Romero, LD; Lopez, JEA; Blanes, JRG; Sanchez-Porras, D; Campos, F; Alaminos, M; Oyonarte-Ramirez, J

ROD2 domain filamin C missense mutations exhibit a distinctive cardiac phenotype with restrictive/hypertrophic cardiomyopathy and saw-tooth myocardium

SPANISH JOURNAL OF CARDIOLOGY, 2023;

FI: 5,9; Q1

Ramos-Maqueda, J; Migueles, JH; Molina-Jiménez, M; Ruiz-González, D; Cabrera-Borrego, E; Salas, AR; Soriano-Maldonado, A; Jimenez-Jaimez, J

Lifestyle physical activity and rapid-rate non-sustained ventricular tachycardia in arrhythmogenic cardiomyopathy

HEART, 2023;

FI: 5,7; Q2

Linschoten, M; Uijl, A; Schut, A; Jakob, CEM; Romao, LR; Bell, RM; McFarlane, E; Stecher, M; Zondag, AGM; van Iperen, EPA; Hermans-van Ast, JF; Lea, NC; Schaap, J; Jewbali, LS; Smits, PC; Patel, RS; Aujayeb, A; van Smeden, M; Siebelink, HJ; Williams, S; Pilgram, L; Tieleman, RG; Williams, B; Asselbergs, FW; Al-Ali, AK; Al-Muhanna, FA; Al-Rubaish, AM; Al-Windy, NYY; Alkhalil, M; Almubarak, YA; Al Nafie, AN; Al Shahrani, M; Al Shehri, AM; Anning, C; Anthonio, RL; Badings, EA; Ball, C; Van Beek, EA; Ten Berg, JM; Von Bergwelt-Baildon, M; Bianco, M; Blagova, OV; Bleijendaal, H; Bor, WL; Borgmann, S; van Boxem, AJM; van den Brink, FS; Bucciarelli-Ducci, C; Van Bussel, BCT; Byrom-Goulthorp, R; Captur, G; Caputo, M; Charlotte, N; vom Dahl, J; Dark, P; De Sutter, J; Degenhardt, C; Delsing, CE; Dolff, S; Dorman, HGR; Drost, JT; Eberwein, L; Emans, ME; Er, AG; Ferreira, JB; Forner, MJ; Friedrichs, A; Gabriel, L; Groenemeijer, BE; Groenendijk, AL; Gruner, B; Guggemos, W; Haerkens-Arends, HE; Hanses, F; Hedayat, B; Heigener, D; van der Heijden, DJ; Hellou, E; Hellwig, K; Henkens, MTHM; Hermanides, RS; Hermans, WRM; van Hessen, MWJ; Heymans, SRB; Hilt, AD; van der Horst, ICC; Hower, M; van Ierssel, SH; Isberner, N; Jensen, B; Kearney, MT; Kielstein, JT; Kietselaer, BLJH; Kochanek, M; Kolk, MZH; Koning, AMH; Kopylov, PY; Kuijper, AFM; Kwakkel-van, ERPJM; Lanznaster, J; van der Linden, MMJM; van der Lingen, ACJ; Linssen, GCM; Lomas, D; Maarse, M; Magdelijns, FJH; Magro, M; Markart, P; Martens, FMAC; Mazzilli, SG; McCann, GP; van der Meer, P; Meijs, MFL; Merle, U; Messiaen, P; Milovanovic, M; Monraats, PS; Montagna, L; Moriarty, A; Moss, AJ; Mosterd, A; Nadalin, S; Nattermann, J; Neufang, M; Nierop, PR; Offerhaus, JA; Van Ofwegen-Hanekamp, CEE; Parker, E; Persoon, AM; Piepel, C; Pinto, YM; Poorhosseini, H; Prasad, S; Raafs, AG; Raichle, C; Rauschning, D; Redon, J; Reidinga, AC; Ribeiro, MIA; Riedel, C; Rieg, S; Ripley, DP; Rommele, C; Rothfuss, K; Ruddel, J; Ruthrich, MM; Salah, R; Saneei, E; Saxena, M; Schellings, DAAM; Scholte, NTB; Schubert, J; Seelig, J; Shafiee, A; Shore, AC; Spinner, C; Stieglitz, S; Strauss, R; Sturkenboom, NH; Tessitore, E; Thomson, RJ; Timmermans, PJR; Tio, RA; Tjong, FVY; Tometten, L; Trauth, J; Van Craenenbroeck, EM; van Veen, HPAA; den Uil, CA; Vehreschild, MJGT; Veldhuis, LI; Veneman, T; Verschure, DO; Voigt, I; Walter, L; vande Watering, DJ; de Vries, JK; vande Wal, RMA; Westendorp, ICD; Westendorp, PHM; Westhoff, T; Weytjens, C; Wierda, E; Wille, K; de With, K; Worm, M; Woudstra, P; Wu, KW; Zaal, R; Zaman, AG; van der Zee, PM; Zijlstra, LE; Alling, TE; Ahmed, R; Bayraktar-Verver, ECE; van Aken, K; Jimenes, FJB; Biole, CA; Den Boer-Penning, P; Bontje, M; Bos, M; Bosch, L; Broekman, M; Broeyer, FJF; de Bruijn, EAW; Bruinsma, S; Cardoso, NM; Cosyns, B; Len, DHV; Dekimpe, E; Domange, J; van Doorn, JL; van DOorn, P; Dormal, F; Drost, IMJ; Dunnink, A; van Eck, JWM; Elshinawy, K; Gevers, RMM; Gognieva, DG; van der Graaf, M; Grangeon, S; Guclu, A; Habib, A; Haenen, NA; Hamilton, K; Handgraaf, S; Heidbuchel, H; Hendriks-van Woerden, M; Hessels-Linnemeijer, BM; Hosseini, K; Huisman, J; Jacobs, TC; Jansen, SE; Janssen, A; Jourdan, K; ten Kate, GL; van Kempen, MJ; Kievit, CM; Kleikers, P; Knufman, N; van der Kooi, SE; Koole, BAS; Koole, MAC; Kui, KK; Kuipers-Elferink, L; Lemoine, I; Lensink, E; van Marrewijk, V; van Ierssel, SH; Meijer, EJ; Melein, AJ; Mesitskaya, DF; van Nes, CPM; Paris, FMA; Perrelli, MG; Pieterse-Rots, A; Pisters, R; Polkerman, BC; van Poppel, A; Reinders, S; Reitsma, MJ; Ruiter, AH; Selder, JL; van der Sluis, A; Sousa, AIC; Tajdini, M; Sanchez, LT; Van de Heyning, CM; Vial, H; Vlieghe, E; Vonkeman, HE; Vreugdenhil, P; de Vries, TAC; Willems, AM; Wils, AM; Zoet-Nugteren, SK

Clinical presentation, disease course, and outcome of COVID-19 in hospitalized patients with and without pre-existing cardiac disease: a cohort study across 18 countries

EUROPEAN HEART JOURNAL, 2022;

FI: 35,855; D1

Escobar-Lopez, L; Ochoa, JP; Royuela, A; Verdonschot, JAJ; Dal Ferro, M; Espinosa, MA; Sabater-Molina, M; Gallego-Delgado, M; Larranaga-Moreira, JM; Garcia-Pinilla, JM; Basurte-Elorz, MT; Rodriguez-Palomares, JF; Climent, V; Bermudez-Jimenez, FJ; Mogollon-Jimenez, MV; Lopez, J; Pena-Pena, ML; Garcia-Alvarez, A; Lopez-Abel, B; Ripoll-Vera, T; Palomino-Doza, J; Bayes-Genis, A; Brugada, R; Idiazabal, U; Mirelis, JG; Dominguez, F; Henkens, MTHM; Krapels, IPC; Brunner, H.G. Paldino, A; Zaffalon, D; Mestroni, L; Sinagra, G; Heymans, SRB; Merlo, M; Garcia-Pavia, P

Clinical Risk Score to Predict Pathogenic Genotypes in Patients With Dilated Cardiomyopathy

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2022;

FI: 27,203; D1

de Frutos, F; Ochoa, JP; Navarro-Penalver, M; Baas, A; Bjerre, J.V.; Zorio, E; Mendez, I; Lorca, R; Verdonschot, JAJ; Garcia-Granja, PE; Bilinska, Z; Fatkin, D; Fuentes-Canamero, ME; Garcia-Pinilla, JM; Garcia-Alvarez, MI; Girolami, F; Barriales-Villa, R; Diez-Lopez, C; Lopes, LR; Wahbi, K; Garcia-Alvarez, A; Rodriguez-Sanchez, I; Rekondo-Olaetxea, J; Rodriguez-Palomares, JF; Gallego-Delgado, M; Meder, B; Kubanek, M; Hansen, FG; Restrepo-Cordoba, MA; Palomino-Doza, J; Ruiz-Guerrero, L; Sarquella-Brugada, G; Perez-Perez, AA; Bermudez-Jimenez, FJ; Ripoll-Vera, T; Rasmussen, T.B.; Jansen, M; Sabater-Molina, M; Elliot, P.M.; Garcia-Pavia, P

Natural History of MYH7-Related Dilated Cardiomyopathy

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2022;

FI: 27,203; D1

Arenal, A; Avila, P; Jimenez-Candil, J; Third, L; Calvo, D; Arribas, F; Fernandez-Portales, J; Merino, JL; Hernandez-Madrid, A; Fernandez-Aviles, FJ; Berruezo, A

Substrate Ablation vs Antiarrhythmic Drug Therapy for Symptomatic Ventricular Tachycardia

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2022;

FI: 27,203; D1

Rodriguez-Leor, O; Hernandez, JMD; Garcia-Camarero, T; del Blanco, BG; Lopez-Palop, R; Fernandez-Nofrerias, E; Ramon, CC; Jimenez-Kockar, M; Jimenez-Mazuecos, J; Salinas, FF; Gomez-Lara, J; Brugaletta, S; Alfonso, F; Palma, R; Gomez-Menchero, AE; Millan, R; Ponce, DT; Vicente, JAL; Ojeda, S; Pinar, E; Fernandez-Pelegrina, E; Morales-Ponce, FJ; Cid-alvarez, AB; Rama-Merchan, JC; Navarro, EM; Escaned, J; from Prado, AP

Instantaneous Wave-Free Ratio for the Assessment of Intermediate Left Main Coronary Artery Stenosis: Correlations With Fractional Flow Reserve/Intravascular Ultrasound and Prognostic Implications: The iLITRO-EPIC07 Study

CIRCULATION-CARDIOVASCULAR INTERVENTIONS, 2022;

FI: 7,514; Q1

Sanchez-Millan, PJ; Gutierrez-Ballesteros, G; Molina-Lerma, M; Macias-Ruiz, R; Jimenez-Jaimez, J; Third, L.; Alvarez, M.

Ablation with zero-fluoroscopy of premature ventricular complexes from aortic sinus cusps: A single-center experience

JOURNAL OF ARRHYTHMIA, 2021;

Soret, P; LeDantec, C; Desvaux, E.; Foulquier, N.; Chassagnol, B; Hubert, S.; Jamin, C; Barturen, G; Desachy, G.; Devauchelle-Pensec, V; Boudjeniba, C; Cornec, D; Saraux, A; Jousse-Joulin, S; Barbarossa, N.; Rodriguez-Pinto, I; DeLanghe, E.; Beretta, L.; chizz

A new molecular classification to drive precision treatment strategies in primary Sjogren's syndrome

NATURE COMMUNICATIONS, 2021;

FI: 14,919; D1

Escobar-Lopez, L; Ochoa, JP; Mirelis, JG; Espinosa, MA; Navarro, M.; Gallego-Delgado, M; Barriales-Villa, R; Robles-Mezcua, A; Basurte-Elorz, MT; Garcia-Moreno, LG; Climent, V; Jimenez-Jaimez, J; Mogollon-Jimenez, MV; Lopez, J.; Penalty-Penalty, ML; Garcia Alvare

Association of Genetic Variants With Outcomes in Patients With Nonischemic Dilated Cardiomyopathy

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2021;

FI: 24,093; D1

Akhtar, MM; Lorenzini, M; Pavlou, M; Ochoa, JP; O'Mahony, C; Restrepo-Cordoba, MA; Segura-Rodriguez, D; Bermudez-Jimenez, F; Molina, P; Cuenca, S; Ader, F; Larranaga-Moreira, JM; Sabater-Molina, M; Garcia-Alvarez, MI; Arantzamendi, LG; Truszkowska, G; Ort

Association of Left Ventricular Systolic Dysfunction Among Carriers of Truncating Variants in Filamin C With Frequent Ventricular Arrhythmia and End-stage Heart Failure

JAMA CARDIOLOGY, 2021;

FI: 14,676; D1

Schwerzmann, M; Ruperti-Repilado, FJ; Baumgartner, H; Bouma, B; Bouchardy, J; Budts, W; Campens, L.; Chessa, M; Marin, M.J.D.; Gabriel, H.; Gallego, P; Garcia-Orta, R; Gonzalez, AE; Jensen, AS; Ladouceur, M; Miranda-Barrio, B; Morissens, M; Pasquet, A; Wheel,

Clinical outcome of COVID-19 in patients with adult congenital heart disease

HEART, 2021;

FI: 5,994; Q1

Goni, L; of the O, V; Barrio-Lopez, MT; Ramos, P; Third, L; Ibanez-Criado, JL; Castellanos, E; Servant, AI; Ruiz, RM; Garcia-Bolao, I; Almendral, J; Martinez-Gonzalez, MA; Ruiz-Canela, M

A Remote Nutritional Intervention to Change the Dietary Habits of Patients Undergoing Ablation of Atrial Fibrillation: Randomized Controlled Trial

JOURNAL OF MEDICAL INTERNET RESEARCH, 2020;

FI: 5,034; D1

Kapelios, CJ; Laroche, C; Crespo-Leiro, MG; Anker, SD; Coats, AJS; Diaz-Molina, B; Filippatos, G; Lainscak, M; Maggioni, AP; McDonagh, T; Mebazaa, A; Metra, M; Moura, B; Mullens, W.; Piepoli, MF; Rosano, GMC; Ruschitzka, F; Seferovic, PM; Lund, L. H.

Association between loop diuretic dose changes and outcomes in chronic heart failure: observations from the ESC-EORP Heart Failure Long-Term Registry.

EUROPEAN JOURNAL OF HEART FAILURE, 2020;

FI: 11,627; D1

Jimenez-Jaimez, J; Macias-Ruiz, R; Bermudez-Jimenez, F; Rubini-Costa, R; Ramirez-Taboada, J; Flores, PIG; Gallo-Padilla, L; Garcia, JDM; Garcia, CM; Suarez, SM; Molina, CF; Lopez, MA; Third, L

Absence of relevant QT interval prolongation in not critically ill COVID-19 patients

SCIENTIFIC REPORTS, 2020;

FI: 3,998; Q1

Jordan-Martinez, L; Rivera-Lopez, R; Bermudez-Jimenez, F; Jimenez-Jaimez, J; Alzueta, J; Barrera-Cordero, A; Rivera-Fernandez, R; Jimenez-Navarro, M; Alvarez, M; Third, L

Atrioventricular block in patients undergoing treatment with bradycardiic drugs. Predictors of pacemaker requirement (vol 73, pg 554, 2020)

SPANISH JOURNAL OF CARDIOLOGY, 2020;

FI: 4,642; Q1

Dominguez, F; Zorio, E; Jimenez-Jaimez, J; Salguero-Bodes, R; Zwart, R; Gonzalez-Lopez, E; Molina, P; Bermudez-Jimenez, F; Slim, JF; Fathom-Boils, A; Bornstein, B; Toquero, J; Segovia, J; Van Tintelen, J.P.; Lara-Pezzi, E; Garcia-Pavia, P.

Clinical characteristics and determinants of the phenotype in TMEM43 arrhythmogenic right ventricular cardiomyopathy type 5

HEART RHYTHM, 2020;

FI: 5,731; Q1

Crotti, L; Spazzolini, C; Tester, DJ; Ghidoni, A; Baruteau, AE; Beckmann, BM; Behr, ER; Bennett, JS; Bezzina, CR; Bhuiyan, ZA; Celiker, A; Cerrone, M; Dagradi, F; From Ferrari, GM; Etheridge, SP; Fatah, M; Garcia-Pavia, P; Al-Ghamdi, S; Hamilton, RM; Al-Hassnan, ZN; Horie, M; Jimenez-Jaimez, J; Kanter, RJ; Kaski, JP; Kotta, MC; Lahrouchi, N; Makita, N; Norrish, G; Odland, HH; Ohno, S; Papagiannis, J; Parati, G; Sekarski, N; Tveten, K; Vatta, M; Webster, G; Wilde, AAM; Wojciak, J; George, AL; Ackerman, MJ; Schwartz, PJ

Calmodulin mutations and life-threatening cardiac arrhythmias: insights from the International Calmodulinopathy Registry.

EUROPEAN HEART JOURNAL, 2019;

FI: 24,889; D1

Perin, F; Trujillo-Quintero, JP; Jimenez-Jaimez, J; del Rey, MDRV; Monserrat, L; Third, L

Two Novel Cases of Autosomal Recessive Noonan Syndrome Associated With LZTR1 Variants

SPANISH JOURNAL OF CARDIOLOGY, 2019;

FI: 5,078; Q1

Nieto-Marin, P; Jimenez-Jaimez, J; Tinaquero, D; Alfayate, S; Utrilla, RG; del Rey, MDRV; Perin, F; Sarquella-Brugada, G; Monserrat, L; Brugada, J; Third, L; Tamargo, J; Delpon, E; Knight, R

Digenic Heterozygosity in SCN5A and CACNA1C Explains the Variable Expressivity of the Long QT Phenotype in a Spanish Family

SPANISH JOURNAL OF CARDIOLOGY, 2019;

FI: 5,078; Q1

Wiesmaierova, S; Petrova, D; Moreno, AA; Catena, A; Hernandez, JAR; Garcia-Retamero, R.

Social support buffers the negative effects of stress in cardiac patients: a cross-sectional study with acute coronary syndrome patients.

JOURNAL OF BEHAVIORAL MEDICINE, 2019;

FI: 2,868; Q1

Bermudez-Jimenez, FJ; Jimenez-Jaimez, J.

Genotype, Family History, and Outcomes in Noncompaction Cardiomyopathy

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2018;

FI: 16,834; D1

Bermudez-Jimenez, FJ; Jimenez-Jaimez, J; Molina, MG; Third, L

Giant biventricular aneurysms: a novel cardiac phenotype in myotubular / centronuclear myopathy

EUROPEAN HEART JOURNAL, 2018;

FI: 23,425; D1

Bermudez-Jimenez, FJ; Carriel, V; Brodehl, A; Alaminos, M; Campos, A; Schirmer, I; Milting, H; April, BA; Alvarez, M; Lopez-Fernandez, S; Garcia-Giustiniani, D; Monserrat, L; Third, L; Jimenez-Jaimez, J

Novel Desmin Mutation p.Glu401Asp Impairs Filament Formation, Disrupts Cell Membrane Integrity, and Causes Severe Arrhythmogenic Left Ventricular Cardiomyopathy / Dysplasia

CIRCULATION, 2018;

FI: 18,881; D1

Dominguez, F; Cuenca, S; Bilinska, Z; Toro, R; Villard, E; Barriales-Villa, R; Ochoa, JP; Asselbergs, F; Sammani, A; Franaszczyk, M; Akhtar, M; Coronado-Albi, MJ; Rangel-Sousa, D; Rodriguez-Palomares, JF; Jimenez-Jaimez, J; Garcia-Pinilla, JM; Ripoll-Vera, T; Mogollon-Jimenez, MV; Fontalba-Romero, A; Garcia-Medina, D; Palomino-Doza, J; by Gonzalo-Calvo, D; Cicerchia, M; Salazar-Mendiguchia, J; Rooms, C; Pankuweit, S; Hey, TM; Mogensen, J; Barton, PJ; Charron, P; Elliott, P; Garcia-Pavia, P

Dilated Cardiomyopathy Due to BLC2-Associated Athanogene 3 (BAG3) Mutations

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2018;

FI: 16,834; D1

Bermejo, J; Yotti, R; Garcia-Orta, R; Sanchez-Fernandez, PL; Castano, M; Segovia-Cubero, J; Escribano-Subias, P; San Roman, JA; Borras, X; Alonso-Gomez, A; Boots, J; Crespo-Leiro, MG; Velasco, S; Bayes-Genis, A; Lopez, A; Munoz-Aguilera, R; de Teresa, E; Gonzalez-Juanatey, JR; Evangelista, A; Mombiela, T; Gonzalez-Mansilla, A; Elizaga, J; Martin-Moreiras, J; Gonzalez-Santos, JM; Moreno-Escobar, E; Fernandez-Aviles, F

Sildenafil for improving outcomes in patients with corrected valvular heart disease and persistent pulmonary hypertension: a multicenter, double-blind, randomized clinical trial

EUROPEAN HEART JOURNAL, 2018;

FI: 23,425; D1

Soriano-Maldonado, A; Vargas-Hitos, JA; Jimenez-Jaimez, J.

Exercise for Patients With Hypertrophic Cardiomyopathy

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2017;

FI: 44,405; D1

Chioncel, O; Mebazaa, A; Harjola, VP; Coats, A. J.; Piepoli, MF; Crespo-Leiro, MG; Laroche, C; Seferovic, PM; Anker, SD; Ferrari, R; Ruschitzka, F; Lopez-Fernandez, S; Miani, D; Filippatos, G; Maggioni, A.P.

Clinical phenotypes and outcome of patients hospitalized for acute heart failure: the ESC Heart Failure Long-Term Registry.

EUROPEAN JOURNAL OF HEART FAILURE, 2017;

FI: 6,968; D1

Alvarez, M; Bertomeu-Gonzalez, V; Arcocha, MF; Morina, P; Third, L; de Loma, AF; Pachon, M; Garcia, A; Pardo, M; Datino, T; Alonso, C; Osca, J

Nonfluoroscopic Catheter Ablation. Results From a Prospective Multicenter Registry

SPANISH JOURNAL OF CARDIOLOGY, 2017;

FI: 4,485; Q1

Jimenez, FJB; Jimenez-Jaimez, J.

Letter to Editor: Functional study is not the only criterion to predict the pathogenicity of a novel mutation for cardiomyopathy.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2017;

FI: 5,68; Q1

Jimenez-Jaimez, J; Martinez, VA; Fernandez, MJ; Jimenez, FB; del Rey, MDRV; Perin, F; Ramirez, JMO; Fernandez, SL; de la Torre, I; Orta, RG; Molina, MG; Cabrerizo, EM; April, BA; Alvarez, M; Ruiz, RM; Correa, C; Third, L

Clinical and Genetic Diagnosis of Nonischemic Sudden Cardiac Death

SPANISH JOURNAL OF CARDIOLOGY, 2017;

FI: 4,485; Q1

Jimenez-Jaimez, J; Jimenez-Fernandez, M; Third, L

Sudden Cardiac Death in Children and Young Adults

NEW ENGLAND JOURNAL OF MEDICINE, 2016;

FI: 59,558; D1

Ortiz-Genga, M.F.; Basin, S; Dal Ferro, M; Zorio, E; Salgado-Aranda, R; Climent, V; Padron-Barthe, L; Hard-Watery, I; Jimenez-Jaimez, J; Hidalgo-Olivares, VM; Garcia-Campo, E; Lanzillo, C; Suarez-Mier, MP; Yonath, H; Marcos-Alonso, S; Ochoa, J.P.; Santome, JL; Garcia-Giustiniani, D; Rodriguez-Garrido, JL; Dominguez, F; Merlo, M; Palomino, J; Grief, M.L.; Trujillo, J.P.; Martin-Vila, A; Stolfo, D; Molina, P; Lara-Pezzi, E; Calvo-Iglesias, FE; Nof, E; Heat, L; Barriales-Villa, R; Gimeno-Blanes, JR; Arad, M; Garcia-Pavia, P; Montserrat, L.

Truncating FLNC Mutations Are Associated With High-Risk Dilated and Arrhythmogenic Cardiomyopathies

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2016;

FI: 17,759; D1

Lopez-Moreno, E; Jimenez-Jaimez, J; Macias-Ruiz, R; Sanchez-Millan, PJ; Alvarez-Lopez, M; Tercedor-Sanchez, L.

Clinical Profile of Arrhythmogenic Right Ventricular Cardiomyopathy With Left Ventricular Involvement

SPANISH JOURNAL OF CARDIOLOGY, 2016;

FI: 4,596; Q1

Jimenez-Jaimez, J; Doza, JP; Ortega, A; Macias-Ruiz, R; Perin, F; del Rey, MMRV; Ortiz-Genga, M; Monserrat, L; Barriales-Villa, R; Blanca, E; Alvarez, M; Third, L

Calmodulin 2 Mutation N98S Is Associated with Unexplained Cardiac Arrest in Infants Due to Low Clinical Penetrance Electrical Disorders

PLOSONE, 2016;

FI: 3,057; Q1

Jimenez-Jaimez, J; Sanchez, L.T.

Letter by Jimenez-Jaimez and Tercedor Sanchez Regarding Article, “Outcome of Apparently Unexplained Cardiac Arrest: Results From Investigation and Follow-Up of the Prospective Cardiac Arrest Survivors With Preserved Ejection Fraction Registry”

CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY, 2016;

FI: 4,428; Q1

Alfonso, F; Perez-Vizcayno, MJ; Cardenas, A; del Blanco, BG; Garcia-Touchard, A; Lopez-Minguez, JR; Benedict, A; Masotti, M; Clog, J; Iniguez, A; Velazquez, M; Moreno, R; Mainar, V; Dominguez, A; Pomar, F; Melgares, R; Rivero, F; Jimenez-Quevedo, P; Gonzalo, N; Fernandez, C; Macaya, C

A Prospective Randomized Trial of Drug-Eluting Balloons Versus Everolimus-Eluting Stents in Patients With In-Stent Restenosis of Drug-Eluting Stents The RIBS IV Randomized Clinical Trial

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2015;

FI: 16,503; D1

Lip, GYH; Rushton-Smith, SK; Goldhaber, SZ; Fitzmaurice, DA; Mantovani, LG; Goto, S; Haas, S; Bassand, JP; Camm, AJ; Ambrosio, G; Jansky, P; Al Mahmeed, W; Oh s; van Eickels, M; Raatikainen, P; Steffel, J; Oto, A; Kayani, G; Accetta, G; Kakkar, AK

Does Sex Affect Anticoagulant Use for Stroke Prevention in Nonvalvular Atrial Fibrillation? The Prospective Global Anticoagulant Registry in the FIELD-Atrial Fibrillation

CIRCULATION-CARDIOVASCULAR QUALITY AND OUTCOMES, 2015;

FI: 5,906; D1

Jimenez-Jaimez, J; Lopez, MA; Sanchez, L.T.

Asymptomatic 43-year-old man with family history of sudden death

HEART, 2015;

FI: 5,595; Q1

Penela, D; Acosta, J; Aguinaga, L; Third, L; Ordonez, A; Fernandez-Armenta, J; Andreu, D; Sanchez, P; Cabanelas, N; Tolosana, JM; Vassanelli, F; Cabrera, M; Korshunov, V; Sitges, M; Brugada, J; Mont, L; Berruezo, A

Ablation of frequent PVC in patients meeting criteria for primary prevention ICD implant: Safety of withholding the implant

HEART RHYTHM, 2015;

FI: 5,076; Q1

Cardona, A; Seshasai, SRK; Davey, J; Arrebola-Moreno, AL; Ambrose, G; Kaski, JC; Ray, K.K.

A meta-analysis of published studies of endothelial dysfunction does not support its routine clinical use

INTERNATIONAL JOURNAL OF CLINICAL PRACTICE, 2015;

FI: 2,566; Q1

ODIN-2023 Leveraging AI based technology to transform the future of health care delivery in Leading Hospitals in Europe

Funder: EUROPEAN COMMISSION

File number: ODIN-2023

Execution time: 05/09/2023 - 31/08/2024

PI: EDUARDO MOLINA NAVARRO

Genotype Specific Arrhythmogenic Mechanisms in Andersen-Tawil Syndrome

Funder: FOUNDATION LA MARATO DE TV3

File number: LAMARATO-2020-01

Execution time: 15/12/2020 - 14/12/2023

IP: JUAN JIMENEZ JAIMEZ

PREDICTORS OF COMPLICATION OF THORACIC ANEURYSM IN GENETIC AND BICUSPID AORTOPATHY.

Funder: COUNCIL OF HEALTH AND FAMILIES

File number: PI-0201-2020

Execution time: 01/01/2021 - 31/12/2023

PI: ROCIO GARCIA ORTA

Randomized trial of prevention of recurrent arrhythmias with a Mediterranean diet (PREDIMAR study) in patients with atrial fibrillation.

Funder: CARLOS III HEALTH INSTITUTE - FEDER

File number: PI17 / 01870

Execution time: 01/01/2018 - 31/12/2020

IP: LUIS TERCEDOR SANCHEZ

EVALUATION OF THE EFFECT OF PHYSICAL EXERCISE ON ARRHYTHM RISK IN PATIENTS WITH ARRHYTHMOGENIC MYOCARDIOPATHY: OBSERVATIONAL, PROSPECTIVE, MULTICENTRIC STUDY

Funder: PUBLIC FOUNDATION FOR BIOSANITARY RESEARCH OF ORIENTAL ANDALUCIA ALEJANDRO OTERO (FIBAO)

File number: PI-0398-2018

Execution time: 01/01/2019 - 31/12/2021

IP: JUAN JIMENEZ JAIMEZ

EFFECT OF HISIAN STIMULATION ON STIMULATION-INDUCED MYOCARDIOPATHY: A COMPARATIVE STUDY WITH CONVENTIONAL BIVENTRICULAR RESYNCHRONIZATION

Funder: PUBLIC FOUNDATION FOR BIOSANITARY RESEARCH OF ORIENTAL ANDALUCIA ALEJANDRO OTERO (FIBAO)

File number: PI-0365-2018

Execution time: 01/01/2019 - 31/12/2021

PI: MANUEL MOLINA LERMA

Prevalence in Spain of poor anticoagulation control in patients with 'non-valvular' atrial fibrillation treated with vitamin K antagonists.

Funder: CASA DEL CORAZON FOUNDATION

Type of test: OBSERVATIONAL STUDY WITH MEDICATION

Execution time: 24/04/2023 - 30/12/2024

IP: Prevalence in Spain of poor anticoagulation control in patients with 'non-valvular' atrial fibrillation treated with vitamin K antagonists.

Post-marketing clinical surveillance plan (PMCF) to evaluate the safety and clinical effectiveness of the Supraflex Cruz TM coronary stent in the treatment of multivessel coronary artery disease

Funder: EPIC FOUNDATION

Type of test: CLINICAL RESEARCH WITH PROD. SANIT.

Execution time: 05/05/2023 - 30/07/2025

IP: JUAN CABALLERO BORREGO

Randomized, double-blind, placebo-controlled clinical trial to evaluate mavacamten in adults with symptomatic non-obstructive hypertrophic cardiomyopathy

Financier: MYOKARDIA, INC.

Type of test: CLINICAL TRIAL WITH DRUGS

Execution time: 24/03/2023 - 30/07/2025

IP: JUAN JIMENEZ JAIMEZ

A phase IV, double-blind, placebo-controlled, randomized withdrawal trial to evaluate the use of sodium zirconium cyclosilicate (CSZ) for the treatment of hyperkalemia in patients with symptomatic heart failure with a D fraction.

Funder: ASTRAZENECA AB

Type of test: CLINICAL TRIAL WITH DRUGS

Execution time: 06/07/2023 - 30/12/2024

IP: DIEGO GINES SEGURA RODRIGUEZ

Treatment of functionally insignificant vulnerable plaques in patients with ST-elevation myocardial infarction and multivessel disease. (VULNERABLE Study).

Funder: EPIC FOUNDATION

Type of test: CLINICAL RESEARCH WITH PROD. SANIT.

Execution time: 10/04/2023 - 30/01/2029

IP: JUAN CABALLERO BORREGO

Phase III, multicenter, randomized, double-blind, placebo-controlled, parallel-group study to evaluate the efficacy and safety of abelacimab in high-risk patients with atrial fibrillation who are not considered suitable for

Funder: ANTHOS THERAPEUTICS

Type of test: CLINICAL TRIAL WITH DRUGS

Execution time: 30/06/2023 - 28/05/2025

IP: LUIS TERCEDOR SANCHEZ

Cardiovascular and renal treatment in patients with heart failure with hyperkalemia or at high risk of hyperkalemia (CARE-HK in the HF registry)

Financier: VIFOR (INTERNATIONAL) INC.

Type of test: COMMERCIAL POST AUTHORIZATION STUDY

Execution time: 08/02/2022 - 30/04/2025

IP: SILVIA LOPEZ FERNANDEZ

improveD procEdural workfLow for catheter ablation of paroxysmal AF with high density mapping system and advanced technology DELETE AF study.

Financier: UNIVERSITY OF NAVARRA CLINIC

Type of test: CLINICAL RESEARCH WITH PROD. SANIT.

Execution time: 07/10/2022 - 30/03/2025

IP: MIGUEL ALVAREZ LOPEZ

Early initiation of treatment with Candesartan vs Placebo in genetic carriers of causative DCM mutations without evidence of disease (EARLY-GENE trial)

Funder: FOUNDATION FOR BIOMEDICAL RESEARCH OF THE PUERTA DE HIERRO MAJADAHONDA UNIVERSITY HOSPITAL

Type of test: INDEPENDENT CLINICAL TRIAL

Execution time: 30/03/2022 - 30/05/2026

IP: JUAN JIMENEZ JAIMEZ

A Global Prospective observationAl Study of Real-world management of patients With atrial fibrillation at High Risk of Stroke (GARDENIA)

Funder: ANTHOS THERAPEUTICS

Type of test: OBSERVATIONAL STUDY WITH MEDICATION

Execution time: 20/12/2022 - 31/10/2024

PI: ROSA MACIAS RUIZ

A Phase 2a, Open-label, Pilot Study to Evaluate Efficacy, Pharmacokinetics, Pharmacodynamics, Safety, and Tolerability of MYK-224 in Participants With Symptomatic Hypertrophic Cardiomyopathy and Left Ventricular Outflow Tract Obstruction

Financier: MYOKARDIA, INC.

Type of test: CLINICAL TRIAL WITH DRUGS

Execution time: 08/12/2022 - 01/08/2023

IP: JUAN JIMENEZ JAIMEZ

A Phase III, Randomized, Double-Blind, Placebo-Controlled Trial of Flecainide Acetate Inhalation Solution for Cardioversion of New-Onset Symptomatic Atrial Fibrillation to Sinus Rhythm (RESTORE-1)

Funder: INCARDA THERAPEUTICS, INC

Type of test: CLINICAL TRIAL WITH DRUGS

Execution time: 28/11/2022 - 30/08/2023

IP: LUIS TERCEDOR SANCHEZ

Phase 3, multicenter, randomized, double-blind, placebo-controlled study of intravenous FDY-5301 in patients with anterior ST-segment elevation myocardial infarction. IOCYTE AMI-3

Funder: Faraday Pharmaceuticals, Inc.

Type of test: COMMERCIAL CLINICAL TRIAL

Execution time: 17/01/2022 - 31/08/2024

IP: JOAQUIN SANCHEZ GILA

Phase 2, double-blind, randomized, placebo-controlled, 4-arm study to study symptoms, function, health-related quality of life, and safety of repeated subcutaneous administration of Ponsegromab compared to placebo in adult participants with heart failure

Funder: PFIZER, SLU

Type of test: CLINICAL TRIAL WITH DRUGS

Execution time: 02/12/2022 - 30/10/2024

IP: SILVIA LOPEZ FERNANDEZ

Phase II, multicenter, randomized, parallel, three-arm, placebo-controlled study to evaluate the efficacy and safety of CDR132L in patients with reduced left ventricular ejection fraction (=45%) after myocardial infarction (HF- REVERT)

Funder: CARDIOR PHARMACEUTICALS GMBH

Type of test: COMMERCIAL CLINICAL TRIAL

Execution time: 04/04/2022 - 30/09/2024

PI: JESUS GABRIEL SANCHEZ RAMOS

Clinical investigation of ODOCOR II CCM™ electrodes in patients implanted with an OPTIMIZER system.

Funder: IMPULSE DYNAMICS GERMANY GMBH

Type of test: INV. CLINICA PRODUCT SANITARIO COM.

Execution time: 18/06/2021 - 30/12/2022

IP: MIGUEL ALVAREZ LOPEZ

Observational, prospective, 12-month cohort study to analyze changes in the cardiometabolic profile of switching to lurasidone in patients with schizophrenia. RESPECT study

Financer: ANGELINI PHARMA ESPAÑA, SLU

Type of test: COMMERCIAL POST AUTHORIZATION STUDY

Execution time: 16/03/2021 - 30/03/2022

IP: MANUEL LOPEZ PEREZ

Observational study to evaluate the clinical course of high-risk patients undergoing percutaneous coronary intervention (PCI) with implantation of everolimus-eluting stents, using intracoronary techniques to guide and optimize PCI

Funder: CASA DEL CORAZON FOUNDATION

Type of test: INDEPENDENT POST-AUTHORIZATION STUDY

Execution time: 08/10/2021 - 30/10/2023

IP: JUAN CABALLERO BORREGO

Conduction system pacing and ablation of the atrioventricular node in patients with heart failure, left ventricular ejection fraction >40%, and permanent atrial fibrillation

Financer: RODRIGUEZ

Type of test: INV. INDEP SANITARY PRODUCT CLINIC.

Execution time: 16/12/2021 - 30/01/2027

PI: MANUEL MOLINA LERMA

Parallel randomized study to assess the utility of routine angiographic review 6 months after percutaneous intervention in the left main trunk (ANGELINE Study)

Funder: EPIC FOUNDATION

Type of test: INV. INDEP SANITARY PRODUCT CLINIC.

Execution time: 17/03/2021 - 30/04/2024

IP: JOAQUIN SANCHEZ GILA

Behavior of edoxaban in patients with nonvalvular atrial fibrillation and heart failure in Spain. EMAYI studio.

Funder: SOCIEDAD ESPAÑOLA DE CARDIOLOGÍA

Type of test: INDEPENDENT POST-AUTHORIZATION STUDY

Execution time: 22/01/2021 - 30/08/2022

PI: JESUS GABRIEL SANCHEZ RAMOS

Behavior of edoxaban in patients with nonvalvular atrial fibrillation and heart failure in Spain. EMAYI study

Funder: SOCIEDAD ESPAÑOLA DE CARDIOLOGÍA

Type of test: INDEPENDENT POST-AUTHORIZATION STUDY

Execution time: 22/01/2021 - 30/08/2022

IP: FRANCISCO JOSE BERMUDEZ JIMENEZ

Base of the Product Surveillance Record (PSR) platform

Funder: MEDTRONIC BAKKEN RESEARCH CENTER BV

Type of test: INV. CLINICA PRODUCT SANITARIO COM.

Execution time: 06/09/2021 - 30/06/2031

IP: PABLO SANCHEZ MILLAN

Substrate ablation as concomitant treatment in left atrial macroreentrant atrial tachycardia.

Financer: RODRIGUEZ

Type of test: INV. INDEP SANITARY PRODUCT CLINIC.

Execution time: 29/06/2021 - 15/03/2025

IP: MIGUEL ALVAREZ LOPEZ

Dapagliflozin after percutaneous aortic valve prosthesis implantation.

Funder: SOCIEDAD ESPAÑOLA DE CARDIOLOGÍA

Type of test: INDEPENDENT CLINICAL TRIAL

Execution time: 22/10/2021 - 31/12/2023

IP: JUAN CABALLERO BORREGO

Randomized clinical trial to evaluate the effect of beta-blockers and antiplatelet agents in patients with spontaneous coronary artery dissection.

Funder: SOCIEDAD ESPAÑOLA DE CARDIOLOGÍA

Type of test: INDEPENDENT CLINICAL TRIAL

Execution time: 03/09/2021 - 31/12/2024

PI: EDUARDO MOLINA NAVARRO

X-TRA (Cross therapy for Re-Do Ablation) Strategy of crossing ablation techniques (cryoballoon and radiofrequency) after recurrence of atrial fibrillation and the need for a new procedure.

Financer: TOQUERO

Type of test: INDEPENDENT CLINICAL TRIAL

Execution time: 07/07/2021 - 30/09/2024

IP: MIGUEL ALVAREZ LOPEZ

Multicenter, randomized, double-blind, placebo-controlled study of the efficacy and safety of etripamil nasal spray for the resolution of spontaneous episodes of paroxysmal supraventricular tachycardia. RAPID Study (NODE-301 Part 2)

Funder: MILESTONE PHARMACEUTICALS, INC.

Type of test: COMMERCIAL CLINICAL TRIAL

Execution time: 15/04/2021 - 31/12/2021

IP: LUIS TERCEDOR SANCHEZ

Prospective Observational Registry of Patients with Heart Failure. ICC-SEC Registry

Funder: SOCIEDAD ESPAÑOLA DE CARDIOLOGÍA

Type of test: INDEPENDENT POST-AUTHORIZATION STUDY

Execution time: 19/11/2020 - 19/11/2025

PI: JESUS GABRIEL SANCHEZ RAMOS

BPH registry: HIS BUNDLE PACING (His bundle stimulation registry)

Funder: ABBOTT / SJM COORDINATION CENTER BVBA

Type of test: INV. CLINICA PRODUCT SANITARIO COM.

Execution time: 11/05/2020 - 30/12/2020

PI: MANUEL MOLINA LERMA

Safety and performance of Invicta ventricular DF4 probes with active fixation. APOLLO STUDIO

Funder: SORIN CRM SAS

Type of test: INV. CLINICA PRODUCT SANITARIO COM.

Execution time: 04/08/2020 - 30/10/2024

IP: MIGUEL ALVAREZ LOPEZ

Observational study of inappropriate therapies after ICD replacement

Funder: SORIN CRM SAS

Type of test: INV. CLINICA PRODUCT SANITARIO COM.

Execution time: 17/04/2020 - 30/01/2024

PI: MANUEL MOLINA LERMA

High power radiofrequency applications for faster and safer pulmonary vein ablation - POWER FAST II clinical trial.

Funder: FIBHULP, FOUNDATION FOR BIOMEDICAL RESEARCH OF THE LA PAZ UNIVERSITY HOSPITAL

Type of test: INV. INDEP SANITARY PRODUCT CLINIC.

Execution time: 14/07/2020 - 21/03/2021

PI: ROSA MACIAS RUIZ

Phase II, multicenter, randomized, placebo-controlled, double-blind, parallel-group, search for failure to evaluate the efficacy and safety of BAY 2433334 in patients who have suffered an acute myocardial infarction

Funder: BAYER AG

Type of test: COMMERCIAL CLINICAL TRIAL

Execution time: 14/02/2020 - 30/10/2021

Multi-Center, Multi-National, Open Label, Safety study of Etripamil Nasal Spray for Patients with Paroxysmal Supraventricular Tachycardia Open, multicenter and multinational study on the safety of etripamil nasal spray for patients with

Funder: MILESTONE PHARMACEUTICALS, INC.

Type of test: COMMERCIAL CLINICAL TRIAL

Execution time: 05/03/2020 - 31/08/2021

IP: LUIS TERCEDOR SANCHEZ

Dapagliflozin after implantation of a percutaneous aortic valve prosthesis

Funder: SOCIEDAD ESPAÑOLA DE CARDIOLOGÍA

Type of test: INDEPENDENT CLINICAL TRIAL

Execution time: 14/12/2020 - 31/12/2023

PI: EDUARDO MOLINA NAVARRO

Double-blind, randomized, placebo-controlled, parallel-group study of AP30663 administered intravenously for cardioversion in patients with atrial fibrillation

Funder: SYNEOS HEALTH IVH UK LIMITED (FORMERLY INVENTIV HEALTH CLINICAL UK LTD),

Type of test: COMMERCIAL CLINICAL TRIAL

Execution time: 24/06/2019 - 30/12/2020

IP: LUIS TERCEDOR SANCHEZ

MPE05-Translational Research in Cardiovascular Diseases

Research lines

DIEGO GINES SEGURA RODRIGUEZ

RICARDO FRANCISCO RIVERA LOPEZ

FRANCISCO JOSE BERMUDEZ JIMENEZ

MARIA BELEN GARCIA ORTEGA

JOAQUIN SANCHEZ GILA

PABLO SANCHEZ MILLAN

LUIS THIRD SANCHEZ

EDUARDO MOLINA NAVARRO

MANUEL MOLINA LERMA

EDUARDO MORENO ESCOBAR

JOSE ANTONIO RAMIREZ HERNANDEZ

JESUS ​​GABRIEL SANCHEZ RAMOS

JUAN KNIGHT BORREGO

ROCIO GARCIA ORTA

JUAN JIMENEZ JAIMEZ

MIRIAM JIMENEZ FERNANDEZ

MANUEL LOPEZ PEREZ

SILVIA LOPEZ FERNANDEZ

ROSE MACIAS RUIZ

MIGUEL ALVAREZ LOPEZ

ANTONIO LUIS ARREBOLA MORENO

Research

JESUS GABRIEL SANCHEZ RAMOS