MP22-Biochemistry of Nutrition. Therapeutic Implications
Precision Medicine / IBS-MP22 / Consolidated
Our research group Biochemistry of Nutrition. Therapeutic implications, BioNIT, with reference CTS-461 of the Andalusian Research, Development and Innovation Plan (PAIDI), was established in 1996 and is currently made up of 14 people, the principal investigator (PI) being Dr. Ángel Gil Hernández . Its members are dedicated to both teaching and research. The first is attached to the Department of Biochemistry and Molecular Biology 2 of the University of Granada and the second is carried out in the Institute of Nutrition and Food Technology "José Mataix Verdú", located in the Biomedical Research Center of the Technology Park of Health Sciences of Granada. The group has actively investigated the biological functions of nucleotides in human milk, being recognized as a group of international prestige in this field. We have contributed to clarify the role of these compounds in the metabolism of polyunsaturated fatty acids and lipoproteins during the neonatal period, and in the modulation of the immune response in experimental animals and in premature newborns. The European Union included in Directive 96/4 / EC on infant formulas an annex that recommends nucleotide supplementation of infant formulas (based on cow's milk). Through various research projects and contracts, our group has participated in the design and formulation of nucleotide-supplemented infant diets that are currently marketed by Abbott Laboratories SA, under the brand name PULEVA. Similarly, we have investigated the role of nucleotides in development and tissue repair, verifying that these compounds exert restorative effects on the small intestine and liver in animal models of disease.
Research lines
- Clinical and experimental evaluation of functional foods
- Obesity
- Probiotics and intestinal microbiota.
Research networks
- RESEARCH NETWORK IN PRIMARY ADDICTIONS CARE (RIAPAd) Primary care, chronicity and health promotion
Keywords
Obesity, gut microbiota, probiotics, functional foods
ESTEFANIA SANCHEZ RODRIGUEZ
ALVARO TORRES MARTOS
CARMEN MARIA LEGS SANCHEZ
CARMEN TENORIO JIMENEZ
JULIO RAMON PLAZA DIAZ
MARIA JOSE SAEZ LARA
CONCEPTION MARIA AGUILERA GARCIA
ANA ISABEL ALVAREZ MERCADO
LUIS FONTANA GALICIAN
ANGEL GIL HERNANDEZ
CAROLINA GOMEZ LLORENTE
ANDREA MENDEZ GUTIERREZ
MARIA DOLORES MESA GARCIA
JULIO RAMON PLAZA DIAZ
CELIA RODRIGUEZ PEREZ
FRANCISCO JAVIER RUIZ OJEDA
Learning positive-negative rule-based fuzzy associative classifiers with a good trade-off between complexity and accuracy
FUZZY SETS AND SYSTEMS, 2023;
FI: 3,9; Q1
Optimization of human skin keratinocyte culture protocols using bioactive molecules derived from olive oil
BIOMEDICINE & PHARMACOTHERAPY, 2023;
FI: 7,5; Q1
Added Sugar Consumption in Spanish Children (7-12 y) and Nutrient Density of Foods Contributing to Such Consumption: An Observational Study
NUTRIENTS, 2023;
FI: 5,9; Q1
Editorial: Interplay between gut microbiota and the immune system in liver surgery and liver diseases
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, 2023;
FI: 5,7; Q2
The Interplay between Microbiota and Chemotherapy-Derived Metabolites in Breast Cancer
METABOLITES, 2023;
FI: 4,1; Q2
Associations Between Dietary Patterns and Incident Type 2 Diabetes: Prospective Cohort Study of 120,343 UK Biobank Participants
DIABETES CARE, 2022;
FI: 17,152; D1
Associations of BMI with COVID-19 vaccine uptake, vaccine effectiveness, and risk of severe COVID-19 outcomes after vaccination in England: a population-based cohort study
LANCET DIABETES & ENDOCRINOLOGY, 2022;
FI: 44,867; D1
H3K18 lactylation marks tissue-specific active enhancers
GENOME BIOLOGY, 2022;
FI: 17,906; D1
Identifying effective characteristics of behavioral weight management interventions for people with serious mental illness: A systematic review with a qualitative comparative analysis
OBESITY REVIEWS, 2022;
FI: 10,867; D1
Lifestyle advice for hypertension or diabetes: trend analysis from 2002 to 2017 in England
BRITISH JOURNAL OF GENERAL PRACTICE, 2022;
FI: 6,302; D1
Relationship in dietary habits variations during COVID-19 lockdown in Kosovo: The COVIDiet study
APPETITE, 2021;
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
Rueda-Robles, A; Audano, M; Alvarez-Mercado, A.I.; Rubio-Tomas, T, 2021;
Association of Diet, Physical Activity Guidelines and Cardiometabolic Risk Markers in Children
NUTRIENTS, 2021;
FI: 5,719; Q1
Bifidobacterium breve CNCM I-4035, Lactobacillus paracasei CNCM I-4034 and Lactobacillus rhamnosus CNCM I-4036 Modulate Macrophage Gene Expression and Ameliorate Damage Markers in the Liver of Zucker-Lepr(fa/fa) Rats
NUTRIENTS, 2021;
FI: 5,719; Q1
Assessment of the Phytochemical and Nutrimental Composition of Dark Chia Seed (Salvia hispanica L.)
FOODS, 2021;
FI: 4,35; Q2
Active Commuting, Physical Activity, and Sedentary Behaviors in Children and Adolescents from Spain: Findings from the ANIBES Study
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, 2020;
Antioxidants and Oxidative Stress in Children: Influence of Puberty and Metabolically Unhealthy Status
ANTIOXIDANTS, 2020;
FI: 5,014; D1
A Multi-Omics Approach Reveals New Signatures in Obese Allergic Asthmatic Children
BIOMEDICINE, 2020;
FI: 4,717; Q1
Are Sugar-Reduced and Whole Grain Infant Cereals Sensorily Accepted at Weaning? A Randomized Controlled Cross-Over Trial
NUTRIENTS, 2020;
FI: 4,546; Q1
Associations between Changes in Health Behaviors and Body Weight during the COVID-19 Quarantine in Lithuania: The Lithuanian COVIDiet Study
NUTRIENTS, 2020;
FI: 4,546; Q1
Use of Steatotic Grafts in Liver Transplantation: Current Status
LIVER TRANSPLANTATION, 2019;
FI: 4,159; D1
EGF-GH Axis in Rat Steatotic and Non-steatotic Liver Transplantation From Brain-dead Donors
TRANSPLANTATION, 2019;
FI: 4,743; D1
Common Variants in 22 Genes Regulate Response to Metformin Intervention in Children with Obesity: A Pharmacogenetic Study of a Randomized Controlled Trial
JOURNAL OF CLINICAL MEDICINE, 2019;
FI: 5,688; D1
Mechanisms of Action of Probiotics
ADVANCES IN NUTRITION, 2019;
FI: 7,24; D1
Role of functional fortified dairy products in cardiometabolic health: a systematic review and meta-analyzes of randomized clinical trials
ADVANCES IN NUTRITION, 2019;
FI: 7,24; D1
Immune-Mediated Mechanisms of Action of Probiotics and Synbiotics in Treating Pediatric Intestinal Diseases.
NUTRIENTS, 2018;
FI: 4,196; Q1
Effects of Virgin Olive Oils Differing in Their Bioactive Compound Contents on Metabolic Syndrome and Endothelial Functional Risk Biomarkers in Healthy Adults: A Randomized Double-Blind Controlled Trial
NUTRIENTS, 2018;
FI: 4,196; Q1
Human Milk Oligosaccharides and Immune System Development
NUTRIENTS, 2018;
FI: 4,196; Q1
Inhibitor of apoptosis proteins, NAIP, cIAP1 and cIAP2 expression during macrophage differentiation and M1 / M2 polarization
PLOSONE, 2018;
FI: 2,766; Q1
Nutrients and Diet: A Relationship between Oxidative Stress, Aging, Obesity, and Related Noncommunicable Diseases
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2018;
FI: 4,936; Q2
Modification of appetite by bread consumption: A systematic review of randomized controlled trials
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION, 2017;
FI: 6,077; D1
RE: Statistical Interpretation Error in Metformin Trial Article Response
PEDIATRICS, 2017;
FI: 5,705; D1
Metformin for Obesity in Prepubertal and Pubertal Children: A Randomized Controlled Trial
PEDIATRICS, 2017;
FI: 5,705; D1
A serum metabolomics-driven approach predicts orange juice consumption and its impact on oxidative stress and inflammation in subjects from the BIONAOS study.
MOLECULAR NUTRITION & FOOD RESEARCH, 2017;
FI: 4,323; D1
Liquid chromatography tandem mass spectrometric determination of triterpenes in human fluids: Evaluation of markers of dietary intake of olive oil and metabolic disposition of oleanolic acid and maslinic acid in humans
CHEMICAL ANALYTICS ACTA, 2017;
FI: 4,95; D1
Insights on the health benefits of the bioactive compounds of coffee silverskin extract
JOURNAL OF FUNCTIONAL FOODS, 2016;
FI: 3,973; D1
Preface
FOOD CHEMISTRY, 2016;
FI: 4,052; D1
Folate and long-chain polyunsaturated fatty acid supplementation during pregnancy has long-term effects on the attention system of 8.5-y-old offspring: a randomized controlled trial
AMERICAN JOURNAL OF CLINICAL NUTRITION, 2016;
FI: 6,703; D1
An analogue of atrial natriuretic peptide (C-ANP (4-23)) modulates glucose metabolism in human differentiated adipocytes
MOLECULAR AND CELLULAR ENDOCRINOLOGY, 2016;
FI: 3,859; Q1
Interaction of Giardia intestinalis and Systemic Oxidation in Preschool Children in the Western Highlands of Guatemala
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, 2016;
FI: 2,4; Q1
Preface
FOOD CHEMISTRY, 2015;
FI: 3,391; D1
Variation in hydration status within the normative range is associated with urinary biomarkers of systemic oxidative stress in Guatemalan preschool children.
AMERICAN JOURNAL OF CLINICAL NUTRITION, 2015;
FI: 6,77; D1
Regulation of energy balance by brown adipose tissue: at least three potential roles for physical activity
BRITISH JOURNAL OF SPORTS MEDICINE, 2015;
FI: 5,025; D1
Associations among Inflammatory Biomarkers in the Circulating, Plasmatic, Salivary and Intraluminal Anatomical Compartments in Apparently Healthy Preschool Children from the Western Highlands of Guatemala
PLOSONE, 2015;
FI: 3,234; Q1
New knowledge on the antiglycoxidative mechanism of chlorogenic acid
FOOD & FUNCTION, 2015;
FI: 2,791; Q1
Towards Precision Medicine: Exposome and Omics Analysis using Explainable Artificial Intelligence to Study Their Lifespan Impact on Obesity, Insulin Resistance and Metabolic Health. EXOMAIR
Funder: CARLOS III HEALTH INSTITUTE - FEDER
File number: PI23 / 00028
Execution time: 01/01/2024 - 31/12/2026
PI: CONCEPCION MARIA AGUILERA GARCIA
Cardiovascular disease prevention through a reduced meat intervention in a Mediterranean population (CADIMED): a randomized controlled trial with a metabolomic profiling approach
Funder: STATE RESEARCH AGENCY
File number: PID2021-127312OA-I00
Execution time: 01/09/2022 - 31/08/2025
IP: CARMEN MARIA PIERNAS SANCHEZ
Multi-omics analysis and validation of vasorin as a new biomarker of metabolic risk in children with obesity
Funder: HEALTH AND CONSUMPTION COUNCIL
File number: PI-0192-2022
Execution time: 18/11/2022 - 17/11/2025
PI: CONCEPCION MARIA AGUILERA GARCIA
DIVERSE – Disentangling the Interplay between behaViors and biomarkERS across the lifeEspAn
Funder: CARLOS III HEALTH INSTITUTE - FEDER
File number: PI22 / 01476
Execution time: 01/01/2023 - 31/12/2025
IP: MARIA DOLORES MESA GARCIA
RD21/0012/0008 Mª DOLORES MESA Primary Care Chronicity and Health Promotion
Funder: CARLOS III HEALTH INSTITUTE - FEDER
File number: RD21 / 0012/0008
Execution time: 01/01/2022 - 31/12/2022
IP: MARIA DOLORES MESA GARCIA
Nutritional strategies to enhance neurogenesis and hippocampal function: use of cocoa as a new treatment for cocaine-induced cognitive alterations
Funder: STATE RESEARCH AGENCY
File number: PID2020-114374RB-I00
Execution time: 01/09/2021 - 31/08/2024
PI: CELIA RODRIGUEZ PEREZ
Molecular Transducers of Physical Exercise and the Activation of Brown Adipose Tissue: in Search of New Therapeutic Targets in Intercellular Communication.
Funder: COUNCIL OF ECONOMIC TRANSFORMATION, INDUSTRY, KNOWLEDGE AND UNIVERSITIES
File number: P18-RT-4455
Execution time: 11/02/2020 - 31/12/2021
PI: CONCEPCION MARIA AGUILERA GARCIA
PI20 / 00563 - OMICS AND ARTIFICIAL INTELLIGENCE AS TOOLS TO UNDERSTAND MOLECULAR MECHANISMS OF INSULIN RESISTANCE IN OBESE CHILDREN DURING PUBERTY
Funder: CARLOS III HEALTH INSTITUTE - FEDER
File number: PI20 / 00563
Execution time: 01/01/2021 - 31/12/2023
PI: CONCEPCION MARIA AGUILERA GARCIA
Metabolomic Analysis of the Effect of a Virgin Olive Oil Enriched in Bioactive Compounds Obtained from the Olive Itself, in Hypertensive Rats
Funder: COUNCIL OF ECONOMIC TRANSFORMATION, INDUSTRY, KNOWLEDGE AND UNIVERSITIES
File number: B-AGR-257-UGR18
Execution time: 01/01/2020 - 30/06/2022
IP: MARIA DOLORES MESA GARCIA
Implications of plasma miRNAs in the development of obesity-associated asthma in the pediatric population. MIRASMA
Funder: COUNCIL OF ECONOMIC TRANSFORMATION, INDUSTRY, KNOWLEDGE AND UNIVERSITIES
File number: A-CTS-263-UGR18
Execution time: 15/01/2020 - 31/12/2022
PI: CAROLINA GOMEZ LLORENTE
Revaluation of plant extracts with potential antiobesogenic effect
Funder: UNIVERSITY OF GRANADA
File number: PPJIA2019-04
Execution time: 01/03/2020 - 28/02/2021
PI: CELIA RODRIGUEZ PEREZ
CONCEPCION AGUILERA - PUBERTY AND METABOLIC RISK IN OBESE CHILDREN: EPIGENETIC ALTERATIONS AND PATHOPHYSIOLOGICAL AND DIAGNOSTIC IMPLICATIONS. PUBMEP study
Funder: CARLOS III HEALTH INSTITUTE - FEDER
File number: PI16 / 00871
Execution time: 01/01/2017 - 31/12/2019
PI: CONCEPCION MARIA AGUILERA GARCIA
Breast and Intestinal Microbiota and Its Relation to Breast Cancer
Funder: COUNCIL OF HEALTH
File number: PI-0538-2017
Execution time: 01/01/2018 - 31/12/2020
PI: LUIS FONTANA GALLEGO
Study of the fetal and maternal microbiota in pregnancies with fetal growth defect and its relationship with biomarkers of inflammation. BIOCIR.
Funder: CARLOS III HEALTH INSTITUTE - FEDER
File number: PI17 / 01215
Execution time: 01/01/2018 - 31/12/2020
PI: CAROLINA GOMEZ LLORENTE
EPIDEMIOLOGICAL STUDY OF THE MICROBIOTA OF CRITICALLY ILL CHILDREN AND ITS RELATIONSHIP WITH THE DEVELOPMENT OF COMPLICATIONS AND BIOMARKERS OF INFLAMMATION
Funder: CARLOS III HEALTH INSTITUTE - FEDER
File number: PI18 / 01334
Execution time: 01/01/2019 - 31/12/2021
IP: MARIA DOLORES MESA GARCIA