MP20-Biomarkers of Metabolic and Bone Diseases
Precision Medicine / IBS-MP20 / Consolidated

The Biomarkers of Metabolic and Bone Diseases group is fundamentally dedicated to the identification of biomarkers and new therapeutic targets in prevalent pathologies.
Research lines
- Development of new diagnostic kits in collaboration with biotechnology companies.
- Clinical trials of antiosteoporotic and antidiabetic drugs.
- Study of the application of new non-invasive techniques (Trabecular Bone Score and 3D Shaper) for the evaluation of the micro and macro bone architecture and the early diagnosis of bone fragility.
- Study of the role of bone and muscle as endocrine organs and the effect of antiosteoporotic drugs on energy metabolism and the vascular system.
- Identification of potential inhibitory molecules of metabolic pathways involved in vascular complications in patients with T2DM through the use of bioinformatic tools (molecular docking and structural biology techniques)
- Genetic, hormonal and nutritional influences on bone fragility
- Interaction between bone fragility, diabetes mellitus and cardiovascular disease as diseases linked to aging.
Research networks
- CIBERFES - Center for Biomedical Research Network on Frailty and Healthy Aging
- CIBEROBN - Center for Biomedical Research in the Physiopathology of Obesity and Nutrition Network
Keywords
Type 2 diabetes, osteoporosis, bone fragility, cardiovascular disease, biomarkers, therapeutic targets
Alba Camacho Cardeñosa
LUIS MARTINEZ HEREDIA
MARIA DEL CARMEN ANDREO LOPEZ
MANUEL EDUARDO CASTILLO GARZON
FRANCISCO JOSE AMARO GAHETE
JONATHAN RUIZ RUIZ
MARIA TRINIDAD GONZALEZ CEJUDO
ARACELI MUÑOZ GARACH
VICTORIA CONTRERAS BOLIVAR
ESTHER UBAGO STEWED
ENRIQUE MORATALLA ARANDA
MANUEL EDUARDO MUÑOZ TORRES
CRISTINA NOVO RODRIGUEZ
REBECA REYES GARCIA
VERONICA AVILA BLONDE
MARIA DOLORES AVILES PEREZ
MARIA LUISA FERNANDEZ SOTO
ANTONIA GARCIA MARTIN
PABLO JOSE LOPEZ-IBARRA LOZANO
Influence of the Mediterranean Diet on Healthy Aging
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023;
FI: 6,208; Q1
Analysis of the Genetic Relationship between Atherosclerosis and Non-Alcoholic Fatty Liver Disease through Biological Interaction Networks
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023;
FI: 6,208; Q1
Cardioprotective function of sclerostin by reducing calcium deposition, proliferation, and apoptosis in human vascular smooth muscle cells
CARDIOVASCULAR DIABETOLOGY, 2023;
FI: 9,3; Q1
The Influence of the Mediterranean Dietary Pattern on Osteoporosis and Sarcopenia
NUTRIENTS, 2023;
FI: 5,9; Q1
Exploring the role of osteoglycin in type 2 diabetes: implications for insulin resistance and vascular pathophysiology
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2023;
FI: 5,1; Q2
Association of shivering threshold time with body composition and brown adipose tissue in young adults
JOURNAL OF THERMAL BIOLOGY, 2022;
FI: 3,189; D1
Association of shivering threshold time with body composition and brown adipose tissue in young adults.
JOURNAL OF THERMAL BIOLOGY, 2022;
FI: 3,189; D1
Effect of a Multicomponent Intervention on Hepatic Steatosis Is Partially Mediated by the Reduction of Intermuscular Abdominal Adipose Tissue in Children With Overweight or Obesity: The EFIGRO Project
DIABETES CARE, 2022;
FI: 17,152; D1
Effect of an Interdisciplinary Weight Loss and Lifestyle Intervention on Obstructive Sleep Apnea Severity The INTERAPNEA Randomized Clinical Trial
JAMA NETWORK OPEN, 2022;
FI: 13,353; D1
Effects of a Family-Based Lifestyle Intervention Plus Supervised Exercise Training on Abdominal Fat Depots in Children With Overweight or Obesity A Secondary Analysis of a Nonrandomized Clinical Trial
JAMA NETWORK OPEN, 2022;
FI: 13,353; D1
Activation of Brown Adipose Tissue and Promotion of White Adipose Tissue Browning by Plant-based Dietary Components in Rodents: A Systematic Review
ADVANCES IN NUTRITION, 2021;
FI: 8,701; D1
3D DXA Hip Differences in Patients with Acromegaly or Adult Growth Hormone Deficiency
JOURNAL OF CLINICAL MEDICINE, 2021;
FI: 4,242; Q1
Acute effect of HIIT on testosterone and cortisol levels in healthy individuals: A systematic review and meta-analysis
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS, 2021;
FI: 4,221; Q1
Alloreactive Immune Response Associated with Human Mesenchymal Stromal Cells Treatment: A Systematic Review
JOURNAL OF CLINICAL MEDICINE, 2021;
FI: 4,242; Q1
Association between coffee consumption and total dietary caffeine intake with cognitive functioning: cross-sectional assessment in an elderly Mediterranean population
EUROPEAN JOURNAL OF NUTRITION, 2021;
FI: 5,619; Q1
Diet quality and nutrient density in subjects with metabolic syndrome: Influence of socioeconomic status and lifestyle factors. A cross-sectional assessment in the PREDIMED-Plus study
CLINICAL NUTRITION, 2020;
FI: 6,36; D1
Analysis of Bone Impairment by 3D DXA Hip Measures in Patients With Primary Hyperparathyroidism: A Pilot Study
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2020;
FI: 5,399; Q1
Circulating Undercarboxylated Osteocalcin as Estimator of Cardiovascular and Type 2 Diabetes Risk in Metabolic Syndrome Patients
SCIENTIFIC REPORTS, 2020;
FI: 3,998; Q1
Effectiveness of Mediterranean Diet Implementation in Dry Eye Parameters: A Study of PREDIMED-PLUS Trial
NUTRIENTS, 2020;
FI: 4,546; Q1
Association between oxidative-stress-related markers and calcified femoral artery in type 2 diabetes patients
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2020;
FI: 3,209; Q2
Canagliflozin and Renal Outcomes in Type 2 Diabetes and Nephropathy
NEW ENGLAND JOURNAL OF MEDICINE, 2019;
FI: 70,67; D1
The involvement of McpB chemoreceptor from Pseudomonas aeruginosa PAO1 in virulence
SCIENTIFIC REPORTS, 2019;
FI: 4,011; Q1
Epidemiological, Clinical and Genetic Study of Hypophosphatasia in A Spanish Population: Identification of Two Novel Mutations in The Alpl Gene
SCIENTIFIC REPORTS, 2019;
FI: 4,011; Q1
Vitamin D Status, Calcium Intake and Risk of Developing Type 2 Diabetes: An Unresolved Issue
NUTRIENTS, 2019;
FI: 4,171; Q1
Factors Predicting the Response to a Vitamin D-Fortified Milk in Healthy Postmenopausal Women
NUTRIENTS, 2019;
FI: 4,171; Q1
Effects of Daily Intake of Calcium and Vitamin D-Enriched Milk in Healthy Postmenopausal Women: A Randomized, Controlled, Double-Blind Nutritional Study.
JOURNAL OF WOMEN'S HEALTH, 2018;
FI: 2,097; D1
Higher Levels of Serum 25-Hydroxyvitamin D Are Related to Improved Glucose Homeostasis in Women with Postmenopausal Osteoporosis
JOURNAL OF WOMEN'S HEALTH, 2018;
FI: 2,097; D1
Circulating levels of sclerostin are associated with cardiovascular mortality
PLOSONE, 2018;
FI: 2,766; Q1
Degradation of bisphenol A and acute toxicity reduction by different thermo-tolerant ascomycete strains isolated from arid soils
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 2018;
FI: 3,974; Q1
Evolutionary parameter extraction for an organic TFT compact model including contact effects
ORGANIC ELECTRONICS, 2018;
FI: 3,68; Q1
Pig cognitive bias affects the conversion of muscle into meat by antioxidant and autophagy mechanisms
ANIMAL, 2017;
FI: 1,921; D1
SNPs in bone-related miRNAs are associated with the osteoporotic phenotype
SCIENTIFIC REPORTS, 2017;
FI: 4,259; Q1
The Canagliflozin and Renal Endpoints in Diabetes with Established Nephropathy Clinical Evaluation (CREDENCE) Study Rationale, Design, and Baseline Characteristics
AMERICAN JOURNAL OF NEPHROLOGY, 2017;
FI: 2,542; Q2
Non-alcoholic fatty liver disease and diabetes
CLINICAL MEDICINE, 2017;
FI: 1,125; Q3
Remission of type 2 diabetes mellitus after bariatric surgery - comparison between procedures
ENDOKRYNOLOGY POLSKA, 2017;
FI: 1,341; Q4
A New Physiological Role for the DNA Molecule as a Protector against Drying Stress in Desiccation-Tolerant Microorganisms
FRONTIERS IN MICROBIOLOGY, 2016;
FI: 4,165; Q1
Metabolomic profile related to cardiovascular disease in patients with type 2 diabetes mellitus: A pilot study
TALANTA, 2016;
FI: 4,035; Q1
Validation of PHPQoL, a Disease-Specific Quality-of-Life Questionnaire for Patients With Primary Hyperparathyroidism
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2016;
FI: 5,531; Q1
Relationship between myostatin and irisin in type 2 diabetes mellitus: a compensatory mechanism to an unfavorable metabolic state?
ENDOCRINE, 2016;
FI: 3,279; Q2
Daily Intake of Milk Enriched with n-3 Fatty Acids, Oleic Acid, and Calcium Improves Metabolic and Bone Biomarkers in Postmenopausal Women
JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION, 2016;
FI: 2,245; Q3
Relationship between serum concentrations of persistent organic pollutants and markers of insulin resistance in a cohort of women with a history of gestational diabetes mellitus.
ENVIRONMENTAL RESEARCH, 2015;
FI: 4,373; D1
Specific Cell Targeting Therapy Bypasses Drug Resistance Mechanisms in African Trypanosomiasis
PLOS PATHOGENS, 2015;
FI: 7,562; D1
Circulating sclerostin and estradiol levels are associated with inadequate response to bisphosphonates in postmenopausal women with osteoporosis.
MATURITAS, 2015;
FI: 2,942; Q1
Metabolomic profile related to cardiovascular disease in patients with type 2 diabetes mellitus: A pilot study.
TALANTA, 2015;
FI: 3,545; Q1
Insulin degludec improves long-term glycaemic control similarly to insulin glargine but with fewer hypoglycaemic episodes in patients with advanced type 2 diabetes on basal-bolus insulin therapy.
DIABETES OBESITY & METABOLISM, 2015;
FI: 6,36; Q1
Diurnal variation in the effect of aerobic exercise on glycemic metabolism and cardiometabolic health in healthy sedentary men and women; DIVA (Diurnal VAriation of Exercise) project
Funder: MINISTRY OF CULTURE AND SPORTS
File number: EXP_77437
Execution time: 28/03/2023 - 30/11/2023
IP: JONATAN RUIZ RUIZ
Integractomy: Integration of multi-omics and image data through the application of Artificial Intelligence algorithms for diagnosis and identification of molecular pathways involved in the development of Rare Diseases
Funder: HEALTH AND CONSUMPTION COUNCIL
File number: EXC-2023-06
Execution time: 01/01/2024 - 31/12/2026
IP: BEATRIZ GARCIA FONTANA
Analysis of bone structural parameters and new biomarkers in people with cystic fibrosis
Funder: CARLOS III HEALTH INSTITUTE - FEDER
File number: PI22 / 00726
Execution time: 01/01/2023 - 31/12/2025
PI: MANUEL EDUARDO MUÑOZ TORRES
Identification of the connection pathways between vascular calcification and bone mineralization in type 2 diabetes mellitus. Evaluation of its blockade as a therapeutic approach.
Funder: CARLOS III HEALTH INSTITUTE - FEDER
File number: PI18 / 00803
Execution time: 01/10/2022 - 30/06/2023
Multisystemic implications of Hypophosphatasia: Role of the microbiota and genotypic characterization of new variants in children and adults
Funder: CARLOS III HEALTH INSTITUTE - FEDER
File number: PI21 / 01069
Execution time: 14/11/2022 - 31/12/2024
IP: BEATRIZ GARCIA FONTANA
CARLOS III HEALTH INSTITUTE,
Funder: CARLOS III HEALTH INSTITUTE - FEDER
File number: CB22 / 03/00058
Execution time: 01/01/2023 - 31/12/2023
IP: JONATAN RUIZ RUIZ
Identification of the differential miRNome associated with digestive and autoimmune alterations in patients with hypophosphatasia as a diagnostic and prognostic tool.
Funder: SPANISH FOUNDATION FOR BONE RESEARCH AND MINERAL METABOLISM
File number: FEIOMM-22-001-BGF
Execution time: 07/10/2022 - 07/10/2023
IP: BEATRIZ GARCIA FONTANA
Multisystem implications of Hypophosphatasia: Role of the microbiota and geno-phenotypic characterization of new variants in children and adults
Funder: CARLOS III HEALTH INSTITUTE - FEDER
File number: PI21 / 01069
Execution time: 01/01/2022 - 31/12/2024
IP: BEATRIZ GARCIA FONTANA
Combined Effect of Exercise and Time Restriction on Ectopic Fat and Metabolic Health in Obese People: The EXTREME Study
Funder: UNIVERSITY OF GRANADA
File number: A-CTS-516-UGR20
Execution time: 01/01/2022 - 30/06/2023
PI: MANUEL EDUARDO MUÑOZ TORRES
CB16 / 10/00475 CIBER - THEMATIC AREA OF FRAGILITY AND AGING
Funder: CARLOS III HEALTH INSTITUTE - FEDER
File number: CB16 / 10/00475
Execution time: 01/01/2017 - 31/12/2018
PI: MANUEL EDUARDO MUÑOZ TORRES
Relationship between trabecular bone score (TBS) parameters, cardiovascular disease and bone fragility in patients with type 2 diabetes
Funder: CARLOS III HEALTH INSTITUTE - FEDER
File number: PI15 / 01207
Execution time: 01/01/2016 - 31/12/2018
PI: MANUEL EDUARDO MUÑOZ TORRES
Identification of Proteins Involved in Vascular Calcification and Bone Mineralization in Patients With Type 2 Diabetes Mellitus
Funder: COUNCIL OF HEALTH
File number: PI-0207-2016
Execution time: 01/01/2017 - 31/12/2019
IP: BEATRIZ GARCIA FONTANA
RELATIONSHIP BETWEEN BONE STRUCTURAL PARAMETERS OBTAINED THROUGH 3D ANALYSIS (3D-SHAPER) AND CARDIOVASCULAR DISEASE IN PATIENTS WITH TYPE 2 DIABETES.
Funder: SPANISH FOUNDATION FOR BONE RESEARCH AND MINERAL METABOLISM
File number: FEIOMM-18-001-MMT
Execution time: 28/11/2018 - 31/12/2019
PI: MANUEL EDUARDO MUÑOZ TORRES
RETROSPECTIVE STUDY OF THE PREVALENCE OF HYPOPHOSPHATASIA IN GRANADA
Funder: SPANISH FOUNDATION FOR BONE RESEARCH AND MINERAL METABOLISM
File number: FEIOMM17-002
Execution time: 13/11/2017 - 02/12/2019
PI: MANUEL EDUARDO MUÑOZ TORRES
CLONING AND EXPRESSION OF RECOMBINANT SLEROSTIN FOR THE STUDY OF ITS FUNCTION AT THE VASCULAR LEVEL.
Funder: SPANISH FOUNDATION FOR BONE RESEARCH AND MINERAL METABOLISM
File number: FEIOMM-18-002-BGF
Execution time: 08/11/2018 - 31/12/2019
IP: BEATRIZ GARCIA FONTANA
Evaluation of bone structural parameters obtained by 3D analysis (3D-Shaper) in patients with type 2 diabetes and their relationship with cardiovascular disease.
Funder: CARLOS III HEALTH INSTITUTE - FEDER
File number: PI18 / 01235
Execution time: 01/01/2019 - 31/12/2021
PI: MANUEL EDUARDO MUÑOZ TORRES
Characterization at the transcriptional level of the genes involved in vascular calcification in diabetic patients. In silico study of the bone proteins sclerostin and osteoglycine to design possible inhibitors as preventive treatment of ac
Funder: COUNCIL OF HEALTH AND FAMILIES
File number: PI-0514-2018
Execution time: 01/01/2019 - 31/12/2021
PI: CRISTINA GARCIA FONTANA
Phase 3, randomized, double-blind, parallel-group, event-based cardiovascular safety study of BI 456906 administered subcutaneously compared with placebo in overweight or obese participants with cardiovascular disease
Financier: BOEHRINGER INGELHEIM ESPAÑA, SA
Type of test: CLINICAL TRIAL WITH DRUGS
Execution time: 07/12/2023 - 30/09/2026
PI: MANUEL EDUARDO MUÑOZ TORRES
PARADIGHM (Physicians Advancing Knowledge of Chronic Hypoparathyroidism): A Registry Study for Patients with Hypoparathyroidism. SHI-PTH-2019-01
Funder: TAKEDA PHARMACEUTICALS INTERNATIONAL AG
Type of test: COMMERCIAL POST AUTHORIZATION STUDY
Execution time: 23/11/2020 - 30/12/2034
PI: MANUEL EDUARDO MUÑOZ TORRES
Phase IIb, multicenter, randomized, double-blind, placebo-controlled study of verinurad and allopurinol in patients with chronic kidney disease and hyperuricemia. SAPPHIRE
Funder: ASTRAZENECA AB
Type of test: COMMERCIAL CLINICAL TRIAL
Execution time: 20/11/2019 - 30/08/2021
PI: MANUEL EDUARDO MUÑOZ TORRES