MP20-Biomarkers of Metabolic and Bone Diseases

Information
Members
Publications
Projects
Clinical trials

The Biomarkers of Metabolic and Bone Diseases group is fundamentally dedicated to the identification of biomarkers and new therapeutic targets in prevalent pathologies.

Research lines

Development of new diagnostic kits in collaboration with biotechnology companies.
Clinical trials of antiosteoporotic and antidiabetic drugs.
Study of the application of new non-invasive techniques (Trabecular Bone Score and 3D Shaper) for the evaluation of the micro and macro bone architecture and the early diagnosis of bone fragility.
Study of the role of bone and muscle as endocrine organs and the effect of antiosteoporotic drugs on energy metabolism and the vascular system.
Identification of potential inhibitory molecules of metabolic pathways involved in vascular complications in patients with T2DM through the use of bioinformatic tools (molecular docking and structural biology techniques)
Genetic, hormonal and nutritional influences on bone fragility
Interaction between bone fragility, diabetes mellitus and cardiovascular disease as diseases linked to aging.

Research networks

CIBERFES - Center for Biomedical Research Network on Frailty and Healthy Aging
CIBEROBN - Center for Biomedical Research in the Physiopathology of Obesity and Nutrition Network

Keywords

Type 2 diabetes, osteoporosis, bone fragility, cardiovascular disease, biomarkers, therapeutic targets

MANUEL EDUARDO CASTILLO GARZON

FRANCISCO JOSE AMARO GAHETE

ORCID

JONATHAN RUIZ RUIZ

ORCID

MARIA TRINIDAD GONZALEZ CEJUDO

ORCID

ARACELI MUÑOZ GARACH

ORCID

VICTORIA CONTRERAS BOLIVAR

ESTHER UBAGO STEWED

ORCID

ENRIQUE MORATALLA ARANDA

MANUEL EDUARDO MUÑOZ TORRES

CRISTINA NOVO RODRIGUEZ

REBECA REYES GARCIA

VERONICA AVILA BLONDE

MARIA DOLORES AVILES PEREZ

ORCID

MARIA LUISA FERNANDEZ SOTO

ANTONIA GARCIA MARTIN

PABLO JOSE LOPEZ-IBARRA LOZANO

Jurado-Fasoli, L; Sanchez-Delgado, G; Alcantara, JMA; Acosta, F.M.; Sanchez-Sanchez, R; Labayen, I; Ortega, F.B.; Martinez-Tellez, B; Ruiz, J.R.

Adults with metabolically healthy overweight or obesity present more brown adipose tissue and higher thermogenesis than their metabolically unhealthy counterparts

EBIOMEDICINE, 2024;

FI: 9,7; D1

Jurado-Fasoli, L; Sanchez-Delgado, G; Say, XY; Yang, W; Kohler, I; Villarroya, F; Aguilera, CM; Hankemeier, T; Ruiz, JR; Martinez-Tellez, B

Cold-induced changes in plasma signaling lipids are associated with a healthier cardiometabolic profile independently of brown adipose tissue

CELL REPORTS MEDICINE, 2024;

FI: 11,7; D1

Marmol-Perez, A; Migueles, JH; Ubago-Guisado, E; Gil-Cosano, JJ; Rodriguez-Solana, A; Redondo-Tébar, A; Llorente-Cantarero, FJ; Labayen, I; Ortega, FB; Ruiz, JR; Gracia-Marco, L

Every Move Counts to Improve Bone Health at Clinical Sites in Young Pediatric Cancer Survivors: The iBoneFIT Project

MEDICINE & SCIENCE IN SPORTS & EXERCISE, 2024;

FI: 4,1; D1

Marmol-Perez, A; Gil-Cosano, JJ; Ubago-Guisado, E; Llorente-Cantarero, FJ; Pascual-Gázquez, JF; Ness, K.K.; Martinez-Vizcaino, V; Ruiz, JR; Gracia-Marco, L

Muscle strength deficits are associated with low bone mineral density in young pediatric cancer survivors: The iBoneFIT project

JOURNAL OF SPORT AND HEALTH SCIENCE, 2024;

FI: 9,7; D1

Brazo-Sayavera, J; Silva, DR; Lang, J.J. Tomkinson, G.R.; Agostinis-Sobrinho, C; Andersen, L.B.; García-Hermoso, A; Gaya, AR; Jurak, G; Lee, E.Y.; Liu, Y; Lubans, D.R.; Okely, AD; Ortega, FB; Ruiz, JR; Tremblay, M.S.; Dos Santos, L.

Physical Fitness Surveillance and Monitoring Systems Inventory for Children and Adolescents: A Scoping Review with a Global Perspective

SPORTS MEDICINE, 2024;

FI: 9,3; D1

Andreo-López, MC; Contreras-Bolívar, V; Muñoz-Torres, M; García-Fontana, B; García-Fontana, C

Influence of the Mediterranean Diet on Healthy Aging

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023;

FI: 6,208; Q1

Andújar-Vera, F; Ferrer-Millán, M; García-Fontana, C; García-Fontana, B; González-Salvatierra, S; de la Torre, R; Martínez-Heredia, L; Riquelme-Gallego, B; Muñoz-Torres, M

Analysis of the Genetic Relationship between Atherosclerosis and Non-Alcoholic Fatty Liver Disease through Biological Interaction Networks

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023;

FI: 6,208; Q1

González-Salvatierra, S; García-Fontana, C; Lacal, J; Andújar-Vera, F; Martínez-Heredia, L; Sanabria de la Torre, R; Ferrer-Millán, M; Moratalla-Aranda, E; Muñoz-Torres, M; García-Fontana, B

Cardioprotective function of sclerostin by reducing calcium deposition, proliferation, and apoptosis in human vascular smooth muscle cells

CARDIOVASCULAR DIABETOLOGY, 2023;

FI: 9,3; Q1

Andreo-López, MC; Contreras-Bolívar, V; García-Fontana, B; García-Fontana, C; Muñoz-Torres, M

The Influence of the Mediterranean Dietary Pattern on Osteoporosis and Sarcopenia

NUTRIENTS, 2023;

FI: 5,9; Q1

González-Salvatierra, S; García-Fontana, B; Martínez-Heredia, L; Lacal, J; Andújar-Vera, F; de la Torre, R; Moratalla-Aranda, E; Lozano-Alonso, S; García-Fontana, C; Muñoz-Torres, M

Exploring the role of osteoglycin in type 2 diabetes: implications for insulin resistance and vascular pathophysiology

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2023;

FI: 5,1; Q2

Mishre, ASDS; Martinez-Tellez, B; Acosta, FM; Sanchez-Delgado, G; Straat, M.E.; Webb, A.G.; Kan, HE; Rensen, PCN; Ruiz, JR

Association of shivering threshold time with body composition and brown adipose tissue in young adults

JOURNAL OF THERMAL BIOLOGY, 2022;

FI: 3,189; D1

Mishre, ASDS; Martinez-Tellez, B; Acosta, FM; Sanchez-Delgado, G; Straat, M.E.; Webb, A.G.; Kan, HE; Rensen, PCN; Ruiz, JR

Association of shivering threshold time with body composition and brown adipose tissue in young adults.

JOURNAL OF THERMAL BIOLOGY, 2022;

FI: 3,189; D1

Cadenas-Sanchez, C; Idoate, F; Head, R; Villanueva, A; Rodriguez-Vigil, B; Medrano, M; Oses, M; Ortega, FB; Ruiz, JR; Labayen, I

Effect of a Multicomponent Intervention on Hepatic Steatosis Is Partially Mediated by the Reduction of Intermuscular Abdominal Adipose Tissue in Children With Overweight or Obesity: The EFIGRO Project

DIABETES CARE, 2022;

FI: 17,152; D1

Carneiro-Barrera, A; Amaro-Gahete, FJ; Guillen-Riquelme, A; Jurado-Fasoli, L; Saez-Roca, G; Martin-Carrasco, C; Buela-Casal, G; Ruiz, JR

Effect of an Interdisciplinary Weight Loss and Lifestyle Intervention on Obstructive Sleep Apnea Severity The INTERAPNEA Randomized Clinical Trial

JAMA NETWORK OPEN, 2022;

FI: 13,353; D1

Cadenas-Sanchez, C; Head, R; Idoate, F; Oses, M; Medrano, M; Villanueva, A; Arenaza, L; Sanz, A; Ortega, FB; Ruiz, JR; Labayen, I

Effects of a Family-Based Lifestyle Intervention Plus Supervised Exercise Training on Abdominal Fat Depots in Children With Overweight or Obesity A Secondary Analysis of a Nonrandomized Clinical Trial

JAMA NETWORK OPEN, 2022;

FI: 13,353; D1

Osuna-Prieto, FJ; Martinez-Tellez, B; Segura-Carretero, A; Ruiz, J.R.

Activation of Brown Adipose Tissue and Promotion of White Adipose Tissue Browning by Plant-based Dietary Components in Rodents: A Systematic Review

ADVANCES IN NUTRITION, 2021;

FI: 8,701; D1

Grace-Marco, L; González-Salvatierra, S; Garcia-Martin, A; Ubago-Guisado, E; Garcia-Fontana, B; Gil-Cosano, JJ; Munoz-Torres, M.

3D DXA Hip Differences in Patients with Acromegaly or Adult Growth Hormone Deficiency

JOURNAL OF CLINICAL MEDICINE, 2021;

FI: 4,242; Q1

Dote-Montero, M; Carneiro-Barrera, A; Martinez-Vizcaino, V; Ruiz, JR; Amaro-Gahete, F.J.

Acute effect of HIIT on testosterone and cortisol levels in healthy individuals: A systematic review and meta-analysis

SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS, 2021;

FI: 4,221; Q1

Sanabria-de la Torre, R; Quinones-Vico, MI; Fernandez-Gonzalez, A; Sanchez-Diaz, M; Montero-Vilchez, T; Sierra-Sanchez, A; Arias-Santiago, S.

Alloreactive Immune Response Associated with Human Mesenchymal Stromal Cells Treatment: A Systematic Review

JOURNAL OF CLINICAL MEDICINE, 2021;

FI: 4,242; Q1

Paz-Graniel, I; Babio, N.; Becerra-Tomas, N; Toledo, E.; Camacho-Barcia, L; Corella, D; Castaner-Nino, O; Romaguera, D; Vioque, J.; Alonso-Gomez, AM; Warnberg, J; Martinez, JA; Serra-Majem, L; Estruch, R; Tinahones, FJ; Fernandez-Aranda, F; Lapetra, J; I paint

Association between coffee consumption and total dietary caffeine intake with cognitive functioning: cross-sectional assessment in an elderly Mediterranean population

EUROPEAN JOURNAL OF NUTRITION, 2021;

FI: 5,619; Q1

Cano-Ibanez, N; Gea, A; Ruiz-Canela, M; Corella, D; Salas-Salvado, J; Schroeder, H; Navarrete-Munoz, EM; Romaguera, D; Martinez, J.A.; Baron-Lopez, FJ; Lopez-Miranda, J; Estruch, R; Riquelme-Gallego, B; Alonso-Gomez, A; Tur, J.A.; Tinahones, FJ; Serra-Majem, L.

Diet quality and nutrient density in subjects with metabolic syndrome: Influence of socioeconomic status and lifestyle factors. A cross-sectional assessment in the PREDIMED-Plus study

CLINICAL NUTRITION, 2020;

FI: 6,36; D1

Grace-Marco, L; Garcia-Fontana, B; Ubago-Guisado, E; Vlachopoulos, D; Garcia-Martin, A; Munoz-Torres, M

Analysis of Bone Impairment by 3D DXA Hip Measures in Patients With Primary Hyperparathyroidism: A Pilot Study

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2020;

FI: 5,399; Q1

Riquelme-Gallego, B; Garcia-Molina, L; Cano-Ibanez, N; Sanchez-Delgado, G; Andujar-Vera, F; Garcia-Fontana, C; Gonzalez-Salvatierra, S; Garcia-Recio, E; Martinez-Ruiz, V; Bueno-Cavanillas, A; Munoz-Torres, M; Garcia-Fontana, B.

Circulating Undercarboxylated Osteocalcin as Estimator of Cardiovascular and Type 2 Diabetes Risk in Metabolic Syndrome Patients

SCIENTIFIC REPORTS, 2020;

FI: 3,998; Q1

Molina-Leyva, I; Molina-Leyva, A; Riquelme-Gallego, B; Cano-Ibanez, N; Garcia-Molina, L; Good-Cavanillas, A

Effectiveness of Mediterranean Diet Implementation in Dry Eye Parameters: A Study of PREDIMED-PLUS Trial

NUTRIENTS, 2020;

FI: 4,546; Q1

Andujar-Vera, F; Garcia-Fontana, C; Lozano-Alonso, S; Gonzalez-Salvatierra, S; Iglesias-Baena, I; Munoz-Torres, M; Garcia-Fontana, B.

Association between oxidative-stress-related markers and calcified femoral artery in type 2 diabetes patients

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2020;

FI: 3,209; Q2

Perkovic, V; Jardine, MJ; Neal, B; Bompoint, S; Heerspink, HJL; Charytan, DM; Edwards, R; Agarwal, R; Bakris, G; Bull, S; Cannon, CP; Capuano, G; Chu, PL; De Zeeuw, D; Greene, T; Levin, A; Pollock, C; Wheeler, DC; Yavin, Y; Zhang, H; Zinman, B; Meininger, G; Brenner, BM; Mahaffey, KW; McGuire, DK; Holman, R; Home, P; Scharfstein, D; Parfrey, P; Shahinfar, S; August, P; Chang, T; Sinha, AD; Januzzi, J; Kolansky, D; Amerena, J; Hillis, G; Gorelick, P; Kissela, B; Kasner, S; Lindley, R; Fulcher, G; Ounadjela, S; Hufert, K; von Ingersleben, G; Gaglia, J; Harris, R; Hudson, M; Turchin, A; Cheifetz, A; Sheth, S; Feuerstein, J; Cohen, S; Li, N; Kolesnyk, I; Aizenberg, D; Pecoits, R; Cherney, D; Obrador, G; Chertow, G; Hawley, C; Ji, LN; Wada, T; Jha, V; Lim, SK; Lim-Abrahan, MA; Santos, F; Chae, DW; Hwang, SJ; Vazelov, E; Rychlik, I; Hadjadj, S; Krane, V; Rosivall, L; De Nicola, L; Dreval, A; Nowicki, M; Schiller, A; Distiller, L; Gorriz, JL; Kolesnyk, M; Morren, F; Goykhman, S; David, C; Yost, L; Wang, H; Hettiarachchi, M; Thimmaiah, R; Koppolu, D; George, S; Schmidt, M; Ignjatovic, J; Chapin, L; Travis, K; Destree, M; Sood, V; Coffee, L; De Brouwer, K; Zaviriukha, V; Starzec, A; Koizumi, M; Lin, G; Chen, E; Lin, P; Leia, C; Mascaro, D; Amigo, A; Limos, A; Abrahamsen, I; Jaffer, S; Guerrero, RAA; Aizenberg, D; Albisu, JP; Alvarisqueta, A; Bartolacci, I; Berli, MA; Bordonava, A; Calella, P; Cantero, MC; Cartasegna, LR; Cercos, E; Coloma, GC; Colombo, H; Commendatore, V; Cuadrado, J; Cuneo, CA; Cusumano, AM; Douthat, WG; Dran, RD; Farias, E; Fernandez, MF; Finkelstein, H; Fragale, G; Fretes, JO; Garcia, NH; Gastaldi, A; Gelersztein, E; Glenny, JA; Gonzalez, JP; Colaso, PDG; Goycoa, C; Greloni, GC; Guinsburg, A; Hermida, S; Juncos, LI; Klyver, MI; Kraft, F; Krynski, F; Lanchiotti, PV; de la Fuente, RAL; Marchetta, N; Mele, P; Nicolai, S; Novoa, PA; Orio, SI; Otreras, F; Oviedo, A; Raffaele, P; Resk, JH; Rista, L; Papini, NR; Sala, J; Santos, JC; Schiavi, LB; Sessa, H; Casabella, TS; Ulla, MR; Valdez, M; Vallejos, A; Villarino, A; Visco, VE; Wassermann, A; Zaidman, CJ; Cheung, NW; Droste, C; Fraser, I; Johnson, D; Mah, PM; Nicholls, K; Packham, D; Proietto, J; Roberts, A; Roger, S; Tsang, V; Raduan, RA; da Costa, FAA; Amodeo, C; Turatti, LAA; Bregman, R; Sanches, FCC; Canani, LH; Chacra, AR; Borges, JLC; Vencio, SAC; Franco, RJD; d'Avila, D; Portes, ED; de Souza, P; Deboni, LM; Fraige, F; Neto, BG; Gomes, M; Kohara, SK; Keitel, E; Saraiva, JFK; Lisboa, HRK; Contieri, FLD; Milagres, R; Montenegro, R; de Brito, CM; Hissa, MN; Sabbag, ARN; Noronha, I; Panarotto, D; Pecoits, R; Pereira, MA; Saporito, W; Scotton, AS; Schuch, T; de Almeida, RS; Ramos, CS; Felicio, JS; Thome, F; Hachmann, JCT; Yamada, S; Hayashida, CY; Petry, TBZ; Zanella, MT; Andreeva, V; Angelova, A; Dimitrov, S; Genadieva, V; Genova-Hristova, G; Hristozov, K; Kamenov, Z; Koundurdjiev, A; Lozanov, L; Margaritov, V; Nonchev, B; Rangelov, R; Shinkov, A; Temelkova, M; Velichkova, E; Yakov, A; Aggarwal, N; Aronson, R; Bajaj, H; Cherney, D; Chouinard, G; Conway, J; Cournoyer, S; DaRoza, G; De Serres, S; Dube, F; Goldenberg, R; Gupta, A; Gupta, M; Henein, S; Khandwala, H; Leiter, L; Madore, F; McMahon, A; Muirhead, N; Pichette, V; Rabasa-Lhoret, R; Steele, A; Tangri, N; Torshizi, A; Woo, V; Zalunardo, N; Montenegro, MAF; Jorquera, JGG; Farina, MM; Gajardo, VS; Vejar, M; Chen, N; Chen, QK; Gan, SL; Kong, YZ; Li, DT; Li, WG; Li, XM; Lin, HL; Liu, J; Lu, WP; Mao, H; Ren, Y; Song, WH; Sun, J; Sun, L; Tu, P; Wang, GX; Yang, JK; Yin, AP; Yu, XQ; Zhao, MH; Zheng, HG; Mendoza, JLA; Arcos, E; Avendano, J; Ruiz, JEAD; Ortiz, LHG; Gonzalez, A; Triana, EH; Higuera, JD; Malaver, N; de Salazar, DIM; Rosero, R; Lozano, MAT; Cometa, LV; Valenzuela, A; Alonso, RDV; Villegas, I; Yupanqui, H; Bartaskova, D; Barton, P; Belobradkova, J; Dohnalova, L; Drasnar, T; Ferkl, R; Halciakova, K; Klokocnikova, V; Kovar, R; Lastuvka, J; Lukac, M; Pesickova, S; Peterka, K; Pumprla, J; Rychlik, I; Saudek, F; Tesar, V; Valis, M; Weiner, P; Zemek, S; Alamartine, E; Borot, S; Cariou, B; Dussol, B; Fauvel, JP; Gourdy, P; Klein, A; Le Meur, Y; Penfornis, A; Roussel, R; Saulnier, PJ; Thervet, E; Zaoui, P; Burst, V; Faghih, M; Faulmann, G; Haller, H; Jerwan-Keim, R; Maxeiner, S; Paschen, B; Plassmann, G; Rose, L; Orellana, RAG; Haase, FP; Diaz, JPM; Roca, LAR; Arenales, JAS; Polo, JVS; Juarez, ET; Csecsei, G; Csiky, B; Danos, P; Deak, L; Dudas, M; Harcsa, E; Keltai, K; Keresztesi, S; Kiss, K; Konyves, L; Major, L; Mileder, M; Molnar, M; Mucsi, J; Oroszlan, T; Ory, I; Paragh, G; Peterfai, E; Petro, G; Revesz, K; Takacs, R; Vangel, S; Vasas, S; Zsom, M; Abraham, O; Bhushan, R; Deepak, D; Edwin, FM; Gopalakrishnan, N; Gracious, N; Hansraj, A; Jain, D; Keshavamurthy, CB; Khullar, D; Manisha, S; Peringat, J; Prasad, N; Satyanarayana, RK; Sreedhar, R; Sreelatha, M; Sudhakar, B; Vyasam, RC; Bonadonna, R; Castellino, P; Ceriello, A; Chiovato, L; De Cosmo, S; De Nicola, L; Derosa, G; Di Carlo, A; Di Cianni, G; Frasca, G; Fuiano, G; Gambaro, G; Garibotto, G; Giorda, C; Malberti, F; Mandreoli, M; Mannucci, E; Orsi, E; Piatti, P; Santoro, D; Sasso, FC; Serviddio, G; Stella, A; Trevisan, R; Veronelli, AM; Zanoli, L; Akiyama, H; Aoki, H; Asano, A; Iitsuka, T; Kajiyama, S; Kashine, S; Kawada, T; Kodera, T; Kono, H; Koyama, K; Kumeda, Y; Miyauchi, S; Mizuyama, K; Niiya, T; Oishi, H; Ota, S; Sakakibara, T; Takai, M; Tomonaga, O; Tsujimoto, M; Wada, T; Wakasugi, M; Wakida, Y; Watanabe, T; Yamada, M; Yanagida, K; Yanase, T; Yumita, W; Gaupsiene, E; Kozloviene, D; Navickas, A; Urbanaviciene, E; Ghani, RA; Kadir, KA; Ali, N; Yusof, MDC; Gan, CL; Ismail, M; Kong, WY; Lam, SW; Lee, LY; Lim, SK; Loh, CL; Manocha, AB; Ng, KS; Ahmad, NNFN; Ratnasingam, V; Bin Shudim, SS; Vengadasalam, P; Munoz, LDA; Salazar, MA; Cruz, JB; Soto, MB; Ramos, JC; Wong, AC; Rotter, JRC; Escalante, TD; Sosa, FEE; Lozano, FF; Cervera, LFF; Baron, PF; Ballesteros, CG; Rangel, JDG; Jimenez, LEH; Santana, SSI; Flores, FJ; Molina, HL; Ceballos, RIL; Blanco, BMD; Franco, GM; Loza, OTM; Rocha, CM; Vera, GO; Castellanos, RO; Calcaneo, JP; Rosano, MAR; Pattzi, HR; Guzman, JR; Joerg, IER; Sanchez, SBS; Mijangos, JHS; Sanson, PS; Orozco, JATY; Chavez, ET; Cepeda, AV; Carrillo, LV; Mesa, JV; Escobedo, RZ; Baker, J; Noonan, P; Scott, R; Walker, R; Watson, E; Williams, M; Young, S; Abejuela, Z; Agra, J; Aquitania, G; Caringal, C; Comia, RS; Delos Santos, L; Gomez, O; Jimeno, C; Tan, G; Tolentino, M; Yao, C; Yap, YE; Ygpuara, MDL; Bijata-Bronisz, R; Hotlos, L; Januszewicz, A; Kaczmarek, B; Kaminska, A; Lazuka, L; Madej, A; Mazur, S; Mlodawska-Choluj, D; Orlowska-Kowalik, G; Popenda, G; Rewerska, B; Sowinski, D; Angelescu, LM; Anghel, V; Avram, RI; Busegeanu, MM; Cif, A; Cosma, D; Crisan, C; Demian, LD; Ferariu, IE; Halmagyi, I; Hancu, N; Munteanu, M; Negru, D; Onaca, AG; Petrica, L; Popa, AR; Ranetti, AE; Serafinceanu, C; Toarba, C; Agafyina, A; Barbarash, O; Barysheva, O; Chizhov, D; Dobronravov, V; Glinkina, I; Grineva, E; Khirmanov, V; Kolmakova, E; Koroleva, T; Kvitkova, L; Marasaev, V; Mkrtumyan, A; Morugova, T; Nagibovich, G; Nagibovich, O; Nedogoda, S; Osipova, I; Raskina, T; Samoylova, Y; Sazonova, O; Shamkhalova, M; Shutemova, E; Shwartz, Y; Uriasyev, O; Vorobyev, S; Zateyshchikova, A; Zateyshshikov, D; Zykova, T; Antic, S; Djordjevic, M; Kendereski, A; Lalic, K; Lalic, N; Popovic-Radinovic, V; Babikova, J; Benusova, O; Buganova, I; Culak, J; Dzupina, A; Dzuponova, J; Fulop, P; Ilavska, A; Martinka, E; Ochodnicka, Z; Pella, D; Smatanova, I; Ahmed, F; Badat, A; Breedt, J; Distiller, L; Govender, V; Govender, R; Joshi, M; Jurgens, J; Latiff, G; Lombard, L; Mookadam, M; Ngcakani, N; Nortje, H; Oosthuizen, H; Pillay-Ramaya, L; Prozesky, H; Reddy, J; Rheeder, P; Seeber, M; Cho, YM; Jeong, IK; Kim, SG; Kim, YH; Kwon, HS; Kwon, MJ; Lee, BW; Lee, J; Lee, MK; Nam, MS; Oh, KH; Park, CY; Park, SH; Yoon, KH; Garcia, PA; Mercadal, LA; Barrios, C; Castro, FC; Guldris, SC; Lopez, MD; de los Rios, JE; Fresnedo, GF; Serrano, AG; Garcia, I; Martinez, FJG; Gimeno, JEJ; Mendoza, ML; Marin, TM; Portillo, CM; Vila, MAM; Torres, MM; Iglesias, JN; Perez, JP; Vera, MP; Perez, JMP; Simon, MAQ; Canonge, RS; Gonzalez, AS; Riera, MT; Madueno, FJT; Plaza, MV; Chang, CT; Chuang, LM; Hsia, TL; Hsieh, CH; Lin, CC; Lu, YC; Sheu, WHH; Barna, O; Bilyk, SD; Botsyurko, V; Dudar, I; Fushtey, I; Godlevska, O; Golovchenko, O; Gyrina, O; Kazmirchuk, A; Komisarenko, I; Korzh, O; Kravchun, N; Legun, O; Mankovskyy, B; Martynyuk, L; Mostovoy, Y; Pashkovska, N; Pererva, L; Pertseva, T; Samoylov, O; Smirnov, I; Svyshchenko, Y; Tomashkevych, H; Topchii, I; Tryshchuk, N; Tseluyko, V; Vizir, V; Vlasenko, M; Zlova, T; Zub, L; Abusnana, S; Railey, M; Abouglila, K; Ainsworth, P; Ali, Z; Arutchelvam, V; Barnard, M; Bellary, S; Davies, E; Davies, M; Davies, S; Dawson, A; El Kossi, M; English, P; Fraser, D; Gnudi, L; Gunstone, A; Hall, T; Hanif, W; Jackson, A; Johnson, A; Joseph, F; Krishnan, S; Kumwenda, M; MacDougall, I; Nixon, P; O'Hare, J; Philip, S; Ramtoola, S; Saxena, M; Sennik, D; Simon, G; Singh, B; Stephens, J; Strzelecka, A; Symonds, R; Turner, W; Wahba, M; Wakeling, J; Wheeler, D; Winocour, P; Abdallah, J; Abdullah, R; Abramowitz, M; Acosta, I; Aiello, J; Akright, L; Akyea-Djamson, A; Alappan, R; Alicic, R; Al-Karadsheh, A; Allison, DC; Arauz-Pacheco, C; Arfeen, S; Arif, A; Arvind, M; Atray, N; Awad, A; Barnhill, P; Barranco, E; Barrera, C; Beacom, M; Behara, V; Belo, D; Bentley-Lewis, R

Canagliflozin and Renal Outcomes in Type 2 Diabetes and Nephropathy

NEW ENGLAND JOURNAL OF MEDICINE, 2019;

FI: 70,67; D1

Garcia-Fontana, C; Vilchez, J. I.; Gonzalez-Requena, M; Gonzalez-Lopez, J; Krell, T; Matilla, MA; Manzanera, M.

The involvement of McpB chemoreceptor from Pseudomonas aeruginosa PAO1 in virulence

SCIENTIFIC REPORTS, 2019;

FI: 4,011; Q1

Garcia-Fontana, C; Villa-Suarez, JM; Andujar-Vera, F; Gonzalez-Salvatierra, S; Martinez-Navajas, G; Real, PJ; Life, JMG; de Haro, T; Garcia-Fontana, B; Munoz-Torres, M

Epidemiological, Clinical and Genetic Study of Hypophosphatasia in A Spanish Population: Identification of Two Novel Mutations in The Alpl Gene

SCIENTIFIC REPORTS, 2019;

FI: 4,011; Q1

Munoz-Garach, A; Garcia-Fontana, B; Munoz-Torres, M.

Vitamin D Status, Calcium Intake and Risk of Developing Type 2 Diabetes: An Unresolved Issue

NUTRIENTS, 2019;

FI: 4,171; Q1

Reyes-Garcia, R; Garcia-Martin, A; Palacios, S; Rooms, N; Mendoza, N; Quesada-Charneco, M; Fonolla, J; Lara-Villoslada, F; Manoz-Torres, M

Factors Predicting the Response to a Vitamin D-Fortified Milk in Healthy Postmenopausal Women

NUTRIENTS, 2019;

FI: 4,171; Q1

Reyes-Garcia, R; Mendoza, N; Palacios, S; Rooms, N; Quesada-Charneco, M; Garcia-Martin, A; Fonolla, J; Lara-Villoslada, F; Munoz-Torres, M

Effects of Daily Intake of Calcium and Vitamin D-Enriched Milk in Healthy Postmenopausal Women: A Randomized, Controlled, Double-Blind Nutritional Study.

JOURNAL OF WOMEN'S HEALTH, 2018;

FI: 2,097; D1

Avila-Rubio, V; Garcia-Fontana, B; Novo-Rodriguez, C; Cantero-Hinojosa, J; Reyes-Garcia, R; Munoz-Torres, M.

Higher Levels of Serum 25-Hydroxyvitamin D Are Related to Improved Glucose Homeostasis in Women with Postmenopausal Osteoporosis

JOURNAL OF WOMEN'S HEALTH, 2018;

FI: 2,097; D1

Novo-Rodriguez, C; Garcia-Fontana, B; Luna-Del Castillo, JD; Andujar-Vera, F; Avila-Rubio, V; Garcia-Fontana, C; Morales-Santana, S; Rozas-Moreno, P; Munoz-Torres, M.

Circulating levels of sclerostin are associated with cardiovascular mortality

PLOSONE, 2018;

FI: 2,766; Q1

Mtibaa, R; Olicon-Hernandez, DR; Well, C; Nasri, M; Mechichi, T; Gonzalez, J; Aranda, E

Degradation of bisphenol A and acute toxicity reduction by different thermo-tolerant ascomycete strains isolated from arid soils

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 2018;

FI: 3,974; Q1

Romero, A; Gonzalez, J; Pecos, R; Deen, MJ; Jimenez-Tejada, J.A.

Evolutionary parameter extraction for an organic TFT compact model including contact effects

ORGANIC ELECTRONICS, 2018;

FI: 3,68; Q1

Pots, Y; Olivan, M; Rubio-Gonzalez, A; de Luxan-Delgado, B; Diaz, F; Sierra, V; Arroyo, L; Pena, R; Bassols, A; Gonzalez, J; Carreras, R; Velarde, A; Munoz-Torres, M; Coto-Montes, A

Pig cognitive bias affects the conversion of muscle into meat by antioxidant and autophagy mechanisms

ANIMAL, 2017;

FI: 1,921; D1

De-Ugarte, L; Caro-Molina, E; Rodriguez-Sanz, M; Garcia-Perez, MA; Olmos, JM; Sosa-Henriquez, M; Perez-Cano, R; Gomez-Alonso, C; Del Rio, L; Mateo-Agudo, J; Blazquez-Cabrera, J.A.; Gonzalez-Macias, J; del Pino-Montes, J; Munoz-Torres, M; Diaz-Curiel, M; Malouf, J; Cano, A; Perez-Castrillon, JL; Nogues, X; Garcia-Giralt, N; Ten-Perez, A

SNPs in bone-related miRNAs are associated with the osteoporotic phenotype

SCIENTIFIC REPORTS, 2017;

FI: 4,259; Q1

Jardine, MJ; Mahaffey, KW; Neal, B; Agarwal, R; Bakris, G.L.; Brenner, B.M.; Bull, S; Cannon, C.P.; Charitan, DM; de Zeeuw, D; Edwards, R; Greene, T; Heerspink, HJL; Levin, A; Pollock, C; Wheeler, DC; Xie, J; Zhang, H.; Zinman, B; Desai, M; Perkovic, V.

The Canagliflozin and Renal Endpoints in Diabetes with Established Nephropathy Clinical Evaluation (CREDENCE) Study Rationale, Design, and Baseline Characteristics

AMERICAN JOURNAL OF NEPHROLOGY, 2017;

FI: 2,542; Q2

Reyes-Garcia, R; Rozas-Moreno, P; Llamoza-Torres, CJ; Mosque-Raya, P

Non-alcoholic fatty liver disease and diabetes

CLINICAL MEDICINE, 2017;

FI: 1,125; Q3

Fernandez-Soto, M.L.; Martin-Leyva, A; Gonzalez-Jimenez, A; Garcia-Rubio, J; Cozar-Ibanez, A; Zamora-Camacho, FJ; Leyva-Martinez, MS; Jimenez-Rios, J.A.; Escobar-Jimenez, F.

Remission of type 2 diabetes mellitus after bariatric surgery - comparison between procedures

ENDOKRYNOLOGY POLSKA, 2017;

FI: 1,341; Q4

Garcia-Fontana, C; Narvaez-Reinaldo, JJ; Castle, F; Gonzalez-Lopez, J; Luke, I; Manzanera, M.

A New Physiological Role for the DNA Molecule as a Protector against Drying Stress in Desiccation-Tolerant Microorganisms

FRONTIERS IN MICROBIOLOGY, 2016;

FI: 4,165; Q1

Garcia-Fontana, B; Morales-Santana, S; Navarro, CD; Rozas-Moreno, P; Genilloud, O; Perez, F.V.; of the Palace, JP; Munoz-Torres, M.

Metabolomic profile related to cardiovascular disease in patients with type 2 diabetes mellitus: A pilot study

TALANTA, 2016;

FI: 4,035; Q1

Webb, SM; Puig-Domingo, M; Villabona, C; Munoz-Torres, M; Marazuela, M; Fernandez, D; Martinez, G; Fuck, E; Sleeves, MA; Perulero, N; Badia, X

Validation of PHPQoL, a Disease-Specific Quality-of-Life Questionnaire for Patients With Primary Hyperparathyroidism

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2016;

FI: 5,531; Q1

Garcia-Fontana, B; Reyes-Garcia, R; Morales-Santana, S; Avila-Rubio, V; Munoz-Garach, A; Rozas-Moreno, P; Munoz-Torres, M.

Relationship between myostatin and irisin in type 2 diabetes mellitus: a compensatory mechanism to an unfavorable metabolic state?

ENDOCRINE, 2016;

FI: 3,279; Q2

Fonolla-Joya, J; Reyes-Garcia, R; Garcia-Martin, A; Lopez-Huertas, E; Munoz-Torres, M.

Daily Intake of Milk Enriched with n-3 Fatty Acids, Oleic Acid, and Calcium Improves Metabolic and Bone Biomarkers in Postmenopausal Women

JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION, 2016;

FI: 2,245; Q3

Arrebola, JP; Gonzalez-Jimenez, A; Fornieles-Gonzalez, C; Artacho-Cordon, F; Olea, N; Escobar-Jimenez, F; Fernandez-Soto, M.L.

Relationship between serum concentrations of persistent organic pollutants and markers of insulin resistance in a cohort of women with a history of gestational diabetes mellitus.

ENVIRONMENTAL RESEARCH, 2015;

FI: 4,373; D1

Unciti-Broceta, JD; Arias, JL; Maceira, J; Soriano, M; Ortiz-Gonzalez, M; Hemandez-Quero, J; Munoz-Torres, M; from Koning, HP; Magez, S; Garcia-Salcedo, JA

Specific Cell Targeting Therapy Bypasses Drug Resistance Mechanisms in African Trypanosomiasis

PLOS PATHOGENS, 2015;

FI: 7,562; D1

Morales-Santana, S; Ten-Perez, A; Olmos, JM; Nogues, X; Sosa, M; Diaz-Curiel, M; Perez-Castrillon, JL; Perez-Cano, R; Torrijos, A; Fuck, E; Del Rio, L; Caeiro-Rey, JR; Reyes-Garcia, R; Garcia-Fontana, B; Gonzalez-Macias, J; Munoz-Torres, M.

Circulating sclerostin and estradiol levels are associated with inadequate response to bisphosphonates in postmenopausal women with osteoporosis.

MATURITAS, 2015;

FI: 2,942; Q1

Garcia-Fontana B; Morales-Santana S; Diaz Navarro C; Rozas-Moreno P; Genilloud O; Vicente Perez

Metabolomic profile related to cardiovascular disease in patients with type 2 diabetes mellitus: A pilot study.

TALANTA, 2015;

FI: 3,545; Q1

Hollander, P; King, AB; Del Prato, S; Sreenan, S; Balci, MK; Munoz-Torres, M; Rosenstock, J; Hansen, CT; Niemeyer, M; Garber, A.J.

Insulin degludec improves long-term glycaemic control similarly to insulin glargine but with fewer hypoglycaemic episodes in patients with advanced type 2 diabetes on basal-bolus insulin therapy.

DIABETES OBESITY & METABOLISM, 2015;

FI: 6,36; Q1

Unraveling The impact of time Restricted eating on the Gut-livEr connection in men and women with Obesity

Funder: CIBEROBN

File number: TARGET-O

Execution time: 01/01/2025 - 31/12/2025

IP: JONATAN RUIZ RUIZ

Multicenter project: Study of sarcopenia and malnutrition using morphofunctional tools, digital imaging, and molecular markers in lung cancer.

Funder: CARLOS III HEALTH INSTITUTE - FEDER

File number: PI24 / 01937

Execution time: 01/01/2025 - 31/12/2027

IP: MARIA LUISA FERNANDEZ SOTO

Multidisciplinary prehabilitation and rehabilitation based on lifestyle changes for improving surgical outcomes in patients with colon cancer: elucidating the underlying mechanisms

Funder: STATE RESEARCH AGENCY

File number: PID2023-147665OA-I00

Execution time: 01/09/2024 - 31/12/2028

IP: FRANCISCO JOSE AMARO GAHETE

3D-BONE. Virtual exercise training and its impact on cortical and trabecular bone compartments in adult survivors of childhood cancer: a peripheral quantitative computed tomography (pQCT) study.

Funder: STATE RESEARCH AGENCY

File number: PID2023-150311OB-I00

Execution time: 01/09/2024 - 31/12/2028

IP: ESTHER UBAGO GUISADO

ANALYSIS OF INFECTIOUS AGENTS AND BIOMARKERS IN WASTEWATER USING WATER BIOSENSE TECHNOLOGY, Waste4BIO

Funder: FIBAO Foundation

File number: INTRAIBS-PI-2023-01

Execution time: 05/04/2024 - 05/04/2025

PI: CRISTINA GARCIA FONTANA

Diurnal variation in the effect of aerobic exercise on glycemic metabolism and cardiometabolic health in healthy sedentary men and women; DIVA (Diurnal VAriation of Exercise) project

Funder: MINISTRY OF CULTURE AND SPORTS

File number: EXP_77437

Execution time: 28/03/2023 - 30/11/2023

IP: JONATAN RUIZ RUIZ

Integractomy: Integration of multi-omics and image data through the application of Artificial Intelligence algorithms for diagnosis and identification of molecular pathways involved in the development of Rare Diseases

Funder: HEALTH AND CONSUMPTION COUNCIL

File number: EXC-2023-06

Execution time: 01/01/2024 - 31/12/2026

IP: BEATRIZ GARCIA FONTANA

Analysis of bone structural parameters and new biomarkers in people with cystic fibrosis

Funder: CARLOS III HEALTH INSTITUTE - FEDER

File number: PI22 / 00726

Execution time: 01/01/2023 - 31/12/2025

PI: MANUEL EDUARDO MUÑOZ TORRES

Identification of the connection pathways between vascular calcification and bone mineralization in type 2 diabetes mellitus. Evaluation of its blockade as a therapeutic approach.

Funder: CARLOS III HEALTH INSTITUTE - FEDER

File number: PI18 / 00803

Execution time: 01/10/2022 - 30/06/2023

Multisystemic implications of Hypophosphatasia: Role of the microbiota and genotypic characterization of new variants in children and adults

Funder: CARLOS III HEALTH INSTITUTE - FEDER

File number: PI21 / 01069

Execution time: 14/11/2022 - 31/12/2024

IP: BEATRIZ GARCIA FONTANA

CARLOS III HEALTH INSTITUTE,

Funder: CARLOS III HEALTH INSTITUTE - FEDER

File number: CB22 / 03/00058

Execution time: 01/01/2023 - 31/12/2023

IP: JONATAN RUIZ RUIZ

Identification of the differential miRNome associated with digestive and autoimmune alterations in patients with hypophosphatasia as a diagnostic and prognostic tool.

Funder: SPANISH FOUNDATION FOR BONE RESEARCH AND MINERAL METABOLISM

File number: FEIOMM-22-001-BGF

Execution time: 07/10/2022 - 07/10/2023

IP: BEATRIZ GARCIA FONTANA

Multisystem implications of Hypophosphatasia: Role of the microbiota and geno-phenotypic characterization of new variants in children and adults

Funder: CARLOS III HEALTH INSTITUTE - FEDER

File number: PI21 / 01069

Execution time: 01/01/2022 - 31/12/2024

IP: BEATRIZ GARCIA FONTANA

Combined Effect of Exercise and Time Restriction on Ectopic Fat and Metabolic Health in Obese People: The EXTREME Study

Funder: UNIVERSITY OF GRANADA

File number: A-CTS-516-UGR20

Execution time: 01/01/2022 - 30/06/2023

PI: MANUEL EDUARDO MUÑOZ TORRES

CB16 / 10/00475 CIBER - THEMATIC AREA OF FRAGILITY AND AGING

Funder: CARLOS III HEALTH INSTITUTE - FEDER

File number: CB16 / 10/00475

Execution time: 01/01/2017 - 31/12/2018

PI: MANUEL EDUARDO MUÑOZ TORRES

Relationship between trabecular bone score (TBS) parameters, cardiovascular disease and bone fragility in patients with type 2 diabetes

Funder: CARLOS III HEALTH INSTITUTE - FEDER

File number: PI15 / 01207

Execution time: 01/01/2016 - 31/12/2018

PI: MANUEL EDUARDO MUÑOZ TORRES

Identification of Proteins Involved in Vascular Calcification and Bone Mineralization in Patients With Type 2 Diabetes Mellitus

Funder: COUNCIL OF HEALTH

File number: PI-0207-2016

Execution time: 01/01/2017 - 31/12/2019

IP: BEATRIZ GARCIA FONTANA

RELATIONSHIP BETWEEN BONE STRUCTURAL PARAMETERS OBTAINED THROUGH 3D ANALYSIS (3D-SHAPER) AND CARDIOVASCULAR DISEASE IN PATIENTS WITH TYPE 2 DIABETES.

Funder: SPANISH FOUNDATION FOR BONE RESEARCH AND MINERAL METABOLISM

File number: FEIOMM-18-001-MMT

Execution time: 28/11/2018 - 31/12/2019

PI: MANUEL EDUARDO MUÑOZ TORRES

RETROSPECTIVE STUDY OF THE PREVALENCE OF HYPOPHOSPHATASIA IN GRANADA

Funder: SPANISH FOUNDATION FOR BONE RESEARCH AND MINERAL METABOLISM

File number: FEIOMM17-002

Execution time: 13/11/2017 - 02/12/2019

PI: MANUEL EDUARDO MUÑOZ TORRES

CLONING AND EXPRESSION OF RECOMBINANT SLEROSTIN FOR THE STUDY OF ITS FUNCTION AT THE VASCULAR LEVEL.

Funder: SPANISH FOUNDATION FOR BONE RESEARCH AND MINERAL METABOLISM

File number: FEIOMM-18-002-BGF

Execution time: 08/11/2018 - 31/12/2019

IP: BEATRIZ GARCIA FONTANA

Evaluation of bone structural parameters obtained by 3D analysis (3D-Shaper) in patients with type 2 diabetes and their relationship with cardiovascular disease.

Funder: CARLOS III HEALTH INSTITUTE - FEDER

File number: PI18 / 01235

Execution time: 01/01/2019 - 31/12/2021

PI: MANUEL EDUARDO MUÑOZ TORRES

Characterization at the transcriptional level of the genes involved in vascular calcification in diabetic patients. In silico study of the bone proteins sclerostin and osteoglycine to design possible inhibitors as preventive treatment of ac

Funder: COUNCIL OF HEALTH AND FAMILIES

File number: PI-0514-2018

Execution time: 01/01/2019 - 31/12/2021

PI: CRISTINA GARCIA FONTANA

A phase 3, randomized, double-blind, placebo-controlled, multicenter study to evaluate the efficacy and safety of ALXN1850 (recombinant alkaline phosphatase) administered subcutaneously in adolescent (12 to <18 years of age) and adult participants with hypophosphatasia who have not been previously treated with asfotase alfa.

Financier: ALEXION PHARMA SPAIN SL

Type of test: CLINICAL TRIAL WITH DRUGS

Execution time: 14/03/2024 - 30/11/2027

PI: MANUEL EDUARDO MUÑOZ TORRES

Phase 3, randomized, double-blind, parallel-group, event-based cardiovascular safety study of BI 456906 administered subcutaneously compared with placebo in overweight or obese participants with cardiovascular disease

Financier: BOEHRINGER INGELHEIM ESPAÑA, SA

Type of test: CLINICAL TRIAL WITH DRUGS

Execution time: 07/12/2023 - 30/09/2026

PI: MANUEL EDUARDO MUÑOZ TORRES

PARADIGHM (Physicians Advancing Knowledge of Chronic Hypoparathyroidism): A Registry Study for Patients with Hypoparathyroidism. SHI-PTH-2019-01

Funder: TAKEDA PHARMACEUTICALS INTERNATIONAL AG

Type of test: COMMERCIAL POST AUTHORIZATION STUDY

Execution time: 23/11/2020 - 30/12/2034

PI: MANUEL EDUARDO MUÑOZ TORRES

Phase IIb, multicenter, randomized, double-blind, placebo-controlled study of verinurad and allopurinol in patients with chronic kidney disease and hyperuricemia. SAPPHIRE

Funder: ASTRAZENECA AB

Type of test: COMMERCIAL CLINICAL TRIAL

Execution time: 20/11/2019 - 30/08/2021

PI: MANUEL EDUARDO MUÑOZ TORRES

MP20-Biomarkers of Metabolic and Bone Diseases

Research lines

Research networks

Keywords

LUCAS JURADO FASOLI

Alba Camacho Cardeñosa

LUIS MARTINEZ HEREDIA

MARIA DEL CARMEN ANDREO LOPEZ

MANUEL EDUARDO CASTILLO GARZON

FRANCISCO JOSE AMARO GAHETE

JONATHAN RUIZ RUIZ

MARIA TRINIDAD GONZALEZ CEJUDO

ARACELI MUÑOZ GARACH

VICTORIA CONTRERAS BOLIVAR

ESTHER UBAGO STEWED

ENRIQUE MORATALLA ARANDA

MANUEL EDUARDO MUÑOZ TORRES

CRISTINA NOVO RODRIGUEZ

REBECA REYES GARCIA

VERONICA AVILA BLONDE

MARIA DOLORES AVILES PEREZ

MARIA LUISA FERNANDEZ SOTO

ANTONIA GARCIA MARTIN

PABLO JOSE LOPEZ-IBARRA LOZANO

Research