MP19-Nutrition, Metabolism, Growth and Development

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Publications
Projects
Clinical trials

The Nutrition, Metabolism, Growth and Development research group is part of the EURISTIKOS Pediatric Research Center of Excellence (www.euristikos.es) of the University of Granada (UGR). It is directed by Cristina Campoy, Professor of Pediatrics at the University of Granada. It is made up of researchers funded by highly competitive public funding research projects-contracts and the rest linked to the Institution or hired through private companies. The research group is multidisciplinary, and includes both basic and clinical researchers, in which there are pediatricians, obstetricians, neurophysiologists, pharmacists, biologists, biochemists, psychologists, biotechnologists, specialists in activity and physical condition, food technologists, nutritionists-dieticians, nurses and computer scientists. In addition, it is a leading group in the area of research in which it works, also being the recipient of different international researchers who request short or medium-term stays with different projects and mobility grants that help to establish new nuclei of collaboration with other institutions. and universities. The EURISTIKOS Center is also a recipient of undergraduate students in Medicine, Nutrition and Food Science and Technology, as well as master's and doctoral students. The teacher. Campoy has coordinated the FP7 NUTRIMENTHE EU Project (Ref. 212652) (2008-2013) (www.nutrimenthe.eu) and coordinates the Master and Interuniversity Doctorate Program: “Genetic, Nutritional and Enviromental Factors for Growth and Development” (www.nutrenvigen-gd.com). He has participated in 7 European Union Research projects {NUHEAL FP5 BIOMED QRLT-1999-00888; EARNEST FP6 FOOD-CT-2005-007036; NUTRIMENTHE FP7; NutriOMICS - EU Marie Curie Program. Ref. 2013 / IEF / 329812; EarlyNutrition FP7 KBBE-2011-1. GA #: 289346; MyNewGut FP7 (KBBE-2013-7. GA No: 613979); DynaHEALTH-HORIZON 2020 GA No: 633595; PREciSE-ERA-HDHL “Nutrition & the Epigenome”)} in which she has been Principal Investigator and in the Leonardo da Vinci Project 2000-2003. In addition, he is a member of the CIBERESP (Epidemiology and Public Health), nº CB06 / 02/0049, 2006}. Principal investigator of the Excellence Project of the Junta de Andalucía PREOBE (P06-CTS- 02341), and of different projects financed by the Ministry of Industry, Health, and Education and Science {REMODEL (FIS) nº 04/2690, EVASYON (FIS ) No. 05/2369, PREOBE-2nd Follow-up (BFU2012-40254-C03-01) and GD-BRAIN (SAF2015-69265-C2-1-R); PI in different projects financed by companies (Laboratorios ORDESA: COGNIS, SMARTFOODS-CIEN, TOLERA-CIEN; Abbott Nutrition: NIGOHealth; Lorgen, SL: Nutrigen-IgG). The group's activity focuses on the study of the influence of nutrition and metabolism on the growth and development of the child, in the different phases: the mother's pre-conception stage, gestation, the perinatal stage, and from birth to adolescence.

Research lines

Search for new infant formulas and foods for infants, children and adolescents.
Development of the Immune System, Immunonutrition, Immunogenetics and Immunoenvironment
Effects of prenatal and postnatal nutrition on metabolic programming. Programming of adult diseases from early stages of life (Early Nutrition Programming)
Effects of endocrine disruptors in the prenatal period and their impact on the different stages of development.
Chronic Diseases in Pediatrics
Environment, life habits and child and adolescent health
Research methodology during human development.
Nutrition and metabolism of lipids and vitamins in the prenatal, neonatal, infancy, childhood and adolescence stages.
Obesity and healthy lifestyles.
Role of nutrigenomics and nutrigenetics in human development and in the origin of diseases.

Antonio Suarez Garcia

ORCID

DIEGO SALAGRE SIMON

ORCID

ANA APRIL MOLINA

ANTONIO EMILIO JEREZ CALERO

ANTONIO MOLINA CARBALLO

ORCID

CARLOS JESUS RUIZ COSANO

ORCID

JOSE UBEROS FERNANDEZ

ORCID

FRANCISCO JOSE TORRES ESPINOLA

ORCID

HATIM AZARYAH

ORCID

CRISTINA CAMPOY FOLGOSO

Mª VICTORIA ESCOLANO MARGARIT

ORCID

MIREIA ESCUDERO MARIN

ORCID

MARIA GARCIA RICOBARAZA

MARIA MERCEDES GARCIA BERMUDEZ

JOSE ANTONIO GARCIA SANTOS

ORCID

FLORIAN HERRMANN

ORCID

ANA NIETO RUIZ

ORCID

JULIO ROMERO GONZALEZ

JUAN LUIS SANTOS PEREZ

ORCID

MANUELA PEÑA CABALLERO

JOSE ANTONIO HURTADO SUAZO

ORCID

MIGUEL ANGEL LOPEZ MARRIED

JOSE MALDONADO LOZANO

MERCEDES BELLIDO GONZALEZ

ORCID

ESTHER OCETE HITA

ORCID

Diaz-Castro J, Reyes-Olavarría D, Toledano JM, Puche-Juarez M, Garcia-Vega JE, Ochoa JJ, Moreno-Fernandez J

Assessment of muscle endocrine function and inflammatory signaling in male school children following a physical activity program

CLINICAL NUTRITION, 2024;

FI: 6,6; D1

Yolanda Peña-López 1, María Slocker-Barrio 2, Juan-Carlos de-Carlos-Vicente 3, Marta Serrano-Megías 4, Iolanda Jordán-García 5, Jordi Rello 6; EUVAE-Kids Study Group Investigators

Outcomes associated with ventilator-associated events (VAE), respiratory infections (VARI), pneumonia (VAP) and tracheobronchitis (VAT) in ventilated pediatric ICU patients: A multicenter prospective cohort study

INTENSIVE CRIT CARE NURS, 2024;

FI: 4,9; D1

Niskanen, A; Barron, A; Azaryah, H; Kerkelä, M; Pulli, E; Tuulari, JJ; Lukkarinen, M; Karlsson, L; Muetzel, RL; Campoy, C; Catena, A; Tiemeier, H; Khandaker, GM; Karlsson, H; Veijola, J; Björnholm, L.

Sex-specific associations between maternal prenatal inflammation and offspring cortical morphology in youth: A harmonized study across four birth cohorts

BRAIN BEHAVIOR AND IMMUNITY, 2024;

FI: 8,8; D1

Salagre, D; Navarro-Alarcón, M; Villalón-Mir, M; Alcázar-Navarrete, B; Gómez-Moreno, G; Tamimi, F; Agil, A

Chronic melatonin treatment improves obesity by inducing uncoupling of skeletal muscle SERCA-SLN mediated by CaMKII/AMPK/PGC1α pathway and mitochondrial biogenesis in female and male Zücker diabetic fatty rats

BIOMEDICINE & PHARMACOTHERAPY, 2024;

FI: 6,9; D1

Salagre, D; Navarro-Alarcón, M; Villalón-Mir, M; Alcázar-Navarrete, B; Gómez-Moreno, G; Tamimi, F; Agil, A

Chronic melatonin treatment improves obesity by inducing uncoupling of skeletal muscle SERCA-SLN mediated by CaMKII/ AMPK/PGC1 α pathway and mitochondrial biogenesis in female and male Zücker diabetic fatty rats (vol 172, 116314)

BIOMEDICINE & PHARMACOTHERAPY, 2024;

FI: 6,9; D1

Nieto-Ruiz, A; Cerdó, T; Jordano, B; Torres-Espínola, FJ; Escudero-Marín, M; García-Ricobaraza, M; Bermúdez, MG; García-Santos, JA; Suárez, A; Campoy, C.

Maternal weight, gut microbiota, and the association with early childhood behavior: the PREOBE follow-up study

CHILD AND ADOLESCENT PSYCHIATRY AND MENTAL HEALTH, 2023;

FI: 5,6; D1

Pig, T; Ruiz-Rodriguez, A; Acuna, I; Torres-Espinola, FJ; Menchen-Marquez, S; Gamiz, F; Gallo, M; Jehmlich, N; Haange, S.B.; von Bergen, M; Campoy, C; Suarez, A

Infant gut microbiota contributes to cognitive performance in mice

CELL HOST & MICROBE, 2023;

FI: 30,3; D1

Cerdó, T; Nieto-Ruiz, A; Garcia-Santos, JA; Rodríguez-Pöhnlein, A; García-Ricobaraza, M; Suárez, A; Bermúdez, MG; Campoy, C.

Current Knowledge About the Impact of Maternal and Infant Nutrition on the Development of the Microbiota-Gut-Brain Axis

ANNUAL REVIEW OF NUTRITION, 2023;

FI: 8,9; D1

Fiore, G; Pascuzzi, MC; Di Profio, E; Corsello, A; Agostinelli, M; La Mendola, A; Milanta, C; Campoy, C; Calcaterra, V; Zuccotti, G; Verduci, E.

Bioactive compounds in childhood obesity and associated metabolic complications: Current evidence, controversies and perspectives

PHARMACOLOGICAL RESEARCH, 2023;

FI: 9,3; D1

Dieguez, E; Nieto-Ruiz, A; Sepúlveda-Valbuena, N; Herrmann, F; Agile, A; De-Castellar, R; Jiménez, J; Azaryah, H; García-Santos, JA; García-Bermúdez, M; Campoy, C.

Long-Term Effects and Potential Impact of Early Nutrition with Breast Milk or Infant Formula on Glucose Homeostasis Control in Healthy Children at 6 Years Old: A Follow-Up from the COGNIS Study

NUTRIENTS, 2023;

FI: 5,9; Q1

Iribarne-Duran, LM; Serrano, L; Hairstyle, FM; Pena-Caballero, M; Hurtado, JA; Vela-Soria, F; Fernandez, MF; Freire, C; Artacho-Cordon, F; Olea, N.

Biomonitoring bisphenols, parabens, and benzophenones in breast milk from a human milk bank in Southern Spain.

SCIENCE OF THE TOTAL ENVIRONMENT, 2022;

FI: 10,753; D1

Bauerl, C; Randazzo, W; Sanchez, G; Selma-Royo, M; Verdevio, EG; Martinez, L; Parra-Llorca, A; Lerin, C; Smoked, V; Crovetto, F; Crispi, F; Perez-Cano, FJ; Rodriguez, G; Ruiz-Redondo, G; Campoy, C; Martinez-Costa, C; Collado, MC

SARS-CoV-2 RNA and antibody detection in breast milk from a prospective multicentre study in Spain

ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION, 2022;

FI: 6,643; D1

Pig, T; Ruiz, A; Acuna, I; Nieto-Ruiz, A; Dieguez, E; Sepulveda-Valbuena, N; Escudero-Marin, M; Garcia-Santos, JA; Garcia-Ricobaraza, M; Herrmann, F; Moreno-Munoz, JA; De Castellar, R; Jimenez, J; Suarez, A; Campoy, C.

A synbiotics, long chain polyunsaturated fatty acids, and milk fat globule membranes supplemented formula modulates microbiota maturation and neurodevelopment

CLINICAL NUTRITION, 2022;

FI: 7,643; Q1

Dieguez, E; Nieto-Ruiz, A; Martin-Perez, C; Sepulveda-Valbuena, N; Herrmann, F; Jimenez, J; De-Castellar, R; Catena, A; Garcia-Santos, JA; Bermudez, MG; Campoy, C.

Association study between hypothalamic functional connectivity, early nutrition, and glucose levels in healthy children aged 6 years: The COGNIS study follow-up

FRONTIERS IN NUTRITION, 2022;

FI: 6,59; Q1

Freire, C; Iribarne-Duran, LM; Gil, F; Olmedo, P; Serrano-Lopez, L; Pena-Caballero, M; Hurtado, JA; Alvarado-Gonzalez, NE; Fernandez, MF; Hairstyle, FM; Artacho-Cordon, F; Olea, N.

Concentrations and determinants of lead, mercury, cadmium, and arsenic in pooled donor breast milk in Spain

INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH, 2022;

FI: 7,401; Q1

Checa-Ros, A; Jerez-Calero, A; Molina-Carballo, A; Campoy, C; Munoz-Hoyos, A.

Current Evidence on the Role of the Gut Microbiome in ADHD Pathophysiology and Therapeutic Implications

NUTRIENTS, 2021;

FI: 5,719; Q1

Hermann, F; Nieto-Ruiz, A; Sepulveda-Valbuena, N.; Miranda, M.T.; Dieguez, E.; Jimenez, J; De-Castellar, R; Garcia-Ricobaraza, M; Garcia-Santos, JA; Bermudez, MG; Campoy, C.

Infant formula enriched with milk fat globule membrane, long-chain polyunsaturated fatty acids, synbiotics, gangliosides, nucleotides and sialic acid reduces infections during the first 18 months of life: The COGNIS study

JOURNAL OF FUNCTIONAL FOODS, 2021;

FI: 4,451; Q1

Sepulveda-Valbuena, N.; Nieto-Ruiz, A; Dieguez, E.; Hermann, F; Escudero-Marin, M; De-Castellar, R; Rodriguez-Palmero, M; Miranda, M.T.; Garcia-Santos, JA; Bermudez, MG; Campoy, C.

Growth patterns and breast milk/infant formula energy efficiency in healthy infants up to 18 months of life: the COGNIS study

BRITISH JOURNAL OF NUTRITION, 2021;

FI: 3,718; Q3

O'Reilly, SL; Burden, C; Campoy, C; McAuliffe, FM; Teede, H; Andresen, J; Campbell, KJ; Geraghty, AA; Harrison, C. L.; Laws, R.; Norman, J.E.; Maindal, H.T.; Vrangbaek, K; Safe, R; Versace, VL; Skinner, T.C.

Bump2Baby and Me: protocol for a randomized trial of mHealth coaching for healthy gestational weight gain and improved postnatal outcomes in high-risk women and their children

TRIALS, 2021;

FI: 2,279; Q4

Campoy, C; Tonato, AMC; Bridge, AD; dePipaon, MS; Verduci, E; Koletzko, B; Casanova, IG; Larque, E.; Valenzuela, R.; Villares, JMM; Gil, A.

Controversy about the critical role of long-chain polyunsaturated fatty acids, arachidonic acid (ARA) and docosahexaenoic acid (DHA), during infancy

HOSPITAL NUTRITION, 2021;

FI: 1,057; Q4

Garcia-Ricobaraza, M; Garcia-Bermudez, M; Torres-Espinola, FJ; Moreno, MTS; Bleyere, MN; Diaz-Prieto, LE; Nova, E; Mark, A; Campoy, C.

Association study of rs1801282 PPARG gene polymorphism and immune cells and cytokine levels in a Spanish pregnant women cohort and their offspring

JOURNAL OF BIOMEDICAL SCIENCE, 2020;

FI: 5,762; Q1

Ubago-Guisado, E; Grace-Marco, L; Medrano, M; Cadenas-Sanchez, C; Arenaza, L; Migueles, JH; Mora-Gonzalez, J; Tobalina, I; Escolano-Margarit, MV; Oses, M; Martin-Matillas, M; Labayen, I; Ortega, FB

Differences in areal bone mineral density between metabolically healthy and unhealthy overweight / obese children: the role of physical activity and cardiorespiratory fitness

PEDIATRIC RESEARCH, 2020;

FI: 2,747; Q1

Azaryah, H; Verdejo-Roman, J; Martin-Perez, C; Garcia-Santos, J.A.; Martinez-Zaldivar, C; Torres-Espinola, FJ; Fields, D; Koletzko, B; Perez-Garcia, M; Catena, A; Campoy, C.

Effects of Maternal Fish Oil and / or 5-Methyl-Tetrahydrofolate Supplementation during Pregnancy on Offspring Brain Resting-State at 10 Years Old: A Follow-Up Study from the NUHEAL Randomized Controlled Trial

NUTRIENTS, 2020;

FI: 4,546; Q1

Impact of gut microbiota on neurogenesis and neurological diseases during infancy.

CURRENT OPINION IN PHARMACOLOGY, 2020;

FI: 4,807; Q1

Nieto-Ruiz, A; Dieguez, E; Sepulveda-Valbuena, N; Catena, E; Jimenez, J; Rodriguez-Palmero, M; Catena, A; Miranda, M.T.; Garcia-Santos, J.A.; Bermudez, M.G.; Campoy, C.

Influence of a Functional Nutrients-Enriched Infant Formula on Language Development in Healthy Children at Four Years Old

NUTRIENTS, 2020;

FI: 4,546; Q1

De Miguel-Etayo, P; Moreno, L.A.; Santabarbara, J; Martin-Matillas, M; Azcona-San Julian, MC; del Moral, AM; Campoy, C; Mark, A; Garagorri, JM

Diet quality index as a predictor of treatment efficacy in overweight and obese adolescents: The EVASYON study

CLINICAL NUTRITION, 2019;

FI: 6,402; D1

Sebert, S; Lowry, E; Aumuller, N; Bermudez, MG; Bjerregaard, LG; de Rooij, SR; De Silva, M; El Marroun, H; Hummel, N; Juola, T; Mason, G; Much, D; Oliveros, E; Poupakis, S; Rautio, N; Schwarzfischer, P; Tzala, E; Uhl, O; van de Beek, C; Vehmeijer, F; Verdejo-Roman, J; Wasenius, N; Webster, C; Ala-Mursula, L; Herzig, KH; Keinanen-Kiukaanniemi, S; Miettunen, J; Baker, JL; Campoy, C; Conti, G; Eriksson, JG; Hummel, S; Jaddoe, V; Koletzko, B; Lewin, A; Rodriguez-Palermo, M; Roseboom, T; Wheel, R; Evans, J; Felix, JF; Prokopenko, I; Sorensen, TIA; Jarvelin, MR

Cohort Profile: The DynaHEALTH consortium - a European consortium for a life-course bio-psychosocial model of healthy aging of glucose homeostasis

INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 2019;

FI: 7,339; D1

Pig, T; Dieguez, E; Campoy, C

Early nutrition and gut microbiome: interrelationship between bacterial metabolism, immune system, brain structure, and neurodevelopment

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2019;

FI: 4,125; Q1

Pig, T; Garcia-Santos, JA; Bermudez, MG; Campoy, C

The Role of Probiotics and Prebiotics in the Prevention and Treatment of Obesity

NUTRIENTS, 2019;

FI: 4,171; Q1

Lorenzo, IS; Tonato, AMC; Bridges, AD; Nieto, A; Herrmann, F; Dieguez, E; Castellote, AI; Lopez-Sabater, MC; Rodriguez-Palmero, M; Campoy, C

The Effect of an Infant Formula Supplemented with AA and DHA on Fatty Acid Levels of Infants with Different FADS Genotypes: The COGNIS Study

NUTRIENTS, 2019;

FI: 4,171; Q1

Torres-Espinola, FJ; Berglund, SK; Garcia, S; Perez-Garcia, M; Catena, A; Wheel, R; Saez, JA; Campoy, C

Visual evoked potentials in offspring born to mothers with overweight, obesity and gestational diabetes

PLOSONE, 2018;

FI: 2,766; Q1

Garcia-Calzon, S; Moleres, A; Gomez-Martinez, S; Diaz, LE; Well, G; Campoy, C; Martinez, JA; Marcos, A; Azcona-Sanjulian, MC; Zalba, G; Marti, A

Association of telomere length with IL-6 levels during an obesity treatment in adolescents: interaction with the-174G / C polymorphism in the IL-6gene

PEDIATRIC OBESITY, 2017;

FI: 3,4; D1

Vasilijevic, J; Zamarreno, N; Oliveros, JC; Rodriguez-Frandsen, A; Gomez, G; Rodriguez, G; Perez-Ruiz, M; Rey, S; Beard, I; Well, F; Houses, I; Nieto, A; Falcon, A

Reduced accumulation of defective viral genomes contributes to severe outcome in influenza virus infected patients.

PLOS PATHOGENS, 2017;

FI: 6,608; D1

Altmae, S; Koel, M; You, U; Adler, P; Suhorutsenko, M; Laisk-Podar, T; Kukushkina, V; Saare, M; Velthut-Meikas, A; Krjutskov, K; Aghajanova, L; Lalitkumar, P. G.; Gemzell-Danielsson, K; Giudice, L; Simon, C; Salumets, A.

Meta-signature of human endometrial receptivity: a meta-analysis and validation study of transcriptomic biomarkers

SCIENTIFIC REPORTS, 2017;

FI: 4,259; Q1

Altmae, S; Segura, M.T.; Stephen, FJ; Bartel, S; Brandy, P; Irmler, M; Beckers, J; Demmelmair, H; Lopez-Sabater, C; Koletzko, B; Krauss-Etschmann, S; Campoy, C.

Maternal Pre-Pregnancy Obesity Is Associated with Altered Placental Transcriptome

PLOSONE, 2017;

FI: 2,806; Q1

Berglund, SK; Torres-Espinola, FJ; Garcia-Valdes, L; Segura, MT; Martinez-Zaldivar, C; Padilla, C; Wheel, R; Garcia, MP; McArdle, HJ; Campoy, C

The impacts of maternal iron deficiency and being overweight during pregnancy on neurodevelopment of the offspring

BRITISH JOURNAL OF NUTRITION, 2017;

FI: 3,706; Q1

Pig, T; Garcia-Valdes, L; Altmae, S; Ruiz, A; Suarez, A; Campoy, C

Role of microbiota function during early life on child's neurodevelopment

TRENDS IN FOOD SCIENCE & TECHNOLOGY, 2016;

FI: 5,15; D1

Catena, A; Munoz-Machicao, J.A.; Torres-Espinola, FJ; Martinez-Zaldivar, C; Diaz-Stone, C; Gil, A; Haile, G; Gyorei, E; Molloy, AM; Decsi, T; Koletzko, B; Campoy, C.

Folate and long-chain polyunsaturated fatty acid supplementation during pregnancy has long-term effects on the attention system of 8.5-y-old offspring: a randomized controlled trial

AMERICAN JOURNAL OF CLINICAL NUTRITION, 2016;

FI: 6,703; D1

Martinez-Tellez, B; Sanchez-Delgado, G; Cadenas-Sanchez, C; Mora-Gonzalez, J; Martin-Matillas, M; Lof, M; Ortega, F.B.; Ruiz, Jr.

Health-related physical fitness is associated with total and central body fat in preschool children aged 3 to 5 years

PEDIATRIC OBESITY, 2016;

FI: 3,689; D1

Aghajanova, L; Altmae, S; Kasvandik, S; Salumets, A; Stavreus-Evers, A; Giudice, L.C.

Stanniocalcin-1 expression in normal human endometrium and dysregulation in endometriosis

FERTILITY AND STERILITY, 2016;

FI: 4,426; D1

Khymenets, O; Rabassa, M; Rodriguez-Palmero, M; Rivero-Urgell, M; Urpi-Sarda, M; Tulipani, S; Brandy, P; Campoy, C; Santos-Buelga, C; Andres-Lacueva, C

Dietary Epicatechin Is Available to Breastfed Infants through Human Breast Milk in the Form of Host and Microbial Metabolites

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2016;

FI: 2,857; D1

Garcia-Valdes, L; Campoy, C; Hayes, H.; Florid, J; Rusanova, I; Miranda, M.T.; McArdle, H. J.

The impact of maternal obesity on iron status, placental transferrin receptor expression and hepcidin expression in human pregnancy.

INTERNATIONAL JOURNAL OF OBESITY, 2015;

FI: 5,004; D1

Torres-Espinola, FJ; Berglund, SK; Garcia-Valdes, LM; Segura, MT; Jerez, A; Campos, D; Moreno-Torres, R; Wheel, R; Catena, A; Perez-Garcia, M; Campoy, C

Maternal Obesity, Overweight and Gestational Diabetes Affect the Offspring Neurodevelopment at 6 and 18 Months of Age - A Follow Up from the PREOBE Cohort

PLOSONE, 2015;

FI: 3,234; Q1

Parn, T; Ruiz, R.G.; Kallak, T. K.; Ruiz, JR; Davey, E; Hreinsson, J; Wanggren, K; Salumets, A; Sjostrom, M; Stavreus-Evers, A; Ortega, F.B.; Altmae, S.