MP16-Intestinal Immunomodulation
Precision Medicine / IBS-MP16 / Consolidated
Development of strategies for the diagnosis, prevention and treatment of digestive and metabolic diseases. Treatment aimed at modulating the intestinal immune system with natural products, synthetic drugs or nutritional strategies. They are part of the personal research group from the Department of Pharmacology (CIBER-ehd; University of Granada), the Department of Pediatrics (University of Granada), the Department of Nutrition and Bromatology (University of Granada) and the UGC of Digestive Endoscopy (Virgen de las Nieves University Hospital, Granada)
Research lines
- Characterization of functional foods with prebiotic properties
- New strategies in the treatment of intestinal and metabolic conditions: inflammatory bowel disease, irritable bowel syndrome, colorectal cancer and metabolic syndrome
Research networks
- CIBEREHD Network Biomedical Research Center Liver and Digestive Diseases
Keywords
Pharmacology, Nutrition, Digestive Endoscopy.
LAURA LOPEZ ESCAMEZ
LUCKMAN GBATI
AILEC HO PLAGARO
THERESA VEZZA
MARIA JESUS RODRIGUEZ SOJO
MARIA JOSE RODRIGUEZ SANCHEZ
BENITO MIRON WELL
JORGE RAMOS SANFIEL
MARIA ELENA RODRIGUEZ HEAD
MIGUEL RUIZ-CABELLO JIMENEZ
FERMIN SANCHEZ DE MEDINA LOPEZ-HUERTAS
MARIA PILAR UTRILLA NAVARRO
MARGARITA MARTINEZ ZALDIVAR
JOSE ALBERTO MOLINA SCISSORS
FLOWER NOGUERAS LOPEZ
MANUEL OLALLA HERRERA
EDUARDO ROUND CHERRY
ALBA RODRIGUEZ NOGALES
LAURA HIDALGO GARCIA
FRANCISCO JOSE HUERTAS PEÑA
MARIA ANGELES LOPEZ GARRIDO
MARIA DEL MAR MARTIN RODRIGUEZ
BENITA MARTIN CASTAÑO
JUAN GABRIEL MARTINEZ FACE
OLGA MARTINEZ AUGUSTIN
ANTONIO MARIA CABALLERO MATEOS
JULIO JUAN GALVEZ PERALTA
RAFAEL GIMENEZ MARTINEZ
RACHEL GONZALEZ PEREZ
Degree: Isolation, identification, and characterization of strains with probiotic activity, from faeces of infants fed exclusively with breast milk
Code: PCT / ES2010 / 000097
Inventors:: GALVEZ PERALTA JULIO JUAN; GARCIA FERNANDEZ JOSE MANUEL; GOMEZ GARCIA MARTA; ORTIZ MELLET CARMEN; RUBIO CASTILLO ENRIQUE MIGUEL; ZARZUELO ZURITA ANTONIO
Degree: NEW CANDIES WITH HIGH CONTENT IN PREBIOTIC OLIGOSCARIDES, PREPARATION AND USE PROCEDURE
Code: P200700675
Administration of intestinal mesenchymal stromal cells reduces colitis-associated cancer in C57BL/6J mice modulating the immune response and gut dysbiosis
PHARMACOLOGICAL RESEARCH, 2023;
FI: 9,3; D1
Performance of the New ABC and MAP(ASH) Scores in the Prediction of Relevant Outcomes in Upper Gastrointestinal Bleeding
JOURNAL OF CLINICAL MEDICINE, 2023;
FI: 3,9; Q2
Non-obstructive jaundice as paraneoplastic syndrome of prostate carcinoma: Systematic review of published cases
CLINICAL MEDICINE, 2023;
FI: 3,9; Q2
Minocycline Prevents the Development of Key Features of Inflammation and Pain in DSS-induced Colitis in Mice
JOURNAL OF PAIN, 2023;
FI: 4; Q2
Risk factors for functional dyspepsia, erosive and non-erosive gastroesophageal reflux disease: A cross-sectional study
GASTROENTEROLOGY AND HEPATOLOGY, 2023;
FI: 1,9; Q4
Modulation of intestinal barrier function by glucocorticoids: Lessons from preclinical models
PHARMACOLOGICAL RESEARCH, 2022;
FI: 10,334; D1
The Antioxidant Activity of Thymus serpyllum Extract Protects against the Inflammatory State and Modulates Gut Dysbiosis in Diet-Induced Obesity in Mice
ANTIOXIDANTS, 2022;
FI: 7,675; D1
The melatonergic agonist agomelatine ameliorates high fat diet-induced obesity in mice through the modulation of the gut microbiome
BIOMEDICINE & PHARMACOTHERAPY, 2022;
FI: 7,419; D1
A New Calcium Vectoring Technology: Concentration and Distribution of Ca and Agronomic Efficiency in Pepper Plants
AGRONOMY-BASEL, 2022;
FI: 3,949; Q1
A Standardized Extract of Lentinula edodes Cultured Mycelium Inhibits Pseudomonas aeruginosa Infectivity Mechanisms
FRONTIERS IN MICROBIOLOGY, 2022;
FI: 6,064; Q1
ABC score: a new risk score that accurately predicts mortality in acute upper and lower gastrointestinal bleeding: an international multicenter study
GUT, 2021;
FI: 23,059; D1
A Gastroenterologist' clinical experience in COVID 19 and in-hospital mortality and length of stay analysis.
POSTGRADUATE MEDICINE, 2021;
FI: 3,84; Q1
A recombinant glucocorticoid-induced leucine zipper protein ameliorates symptoms of dextran sulfate sodium-induced colitis by improving intestinal permeability
FASEB JOURNAL, 2021;
FI: 5,192; Q1
Allium-Derived Compound Propyl Propane Thiosulfonate (PTSO) Attenuates Metabolic Alterations in Mice Fed a High-Fat Diet through Its Anti-Inflammatory and Prebiotic Properties.
NUTRIENTS, 2021;
FI: 5,719; Q1
Changes in gastric emptying of digestible solids in professional cyclists: relationship with exercise intensity
SPANISH JOURNAL OF DIGESTIVE DISEASES, 2021;
FI: 2,086; Q4
Changes to the gut microbiota induced by losartan contributes to its antihypertensive effects
BRITISH JOURNAL OF PHARMACOLOGY, 2020;
FI: 7,73; D1
Anti-Inflammatory and Chemopreventive Effects of Bryophyllum pinnatum (Lamarck) Leaf Extract in Experimental Colitis Models in Rodents
FRONTIERS IN PHARMACOLOGY, 2020;
FI: 4,225; Q1
Circadian Rhythms in Hormone-sensitive Lipase in Human Adipose Tissue: Relationship to Meal Timing and Fasting Duration
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2020;
FI: 5,399; Q1
MAP (ASH): A new scoring system for the prediction of intervention and mortality in upper gastrointestinal bleeding
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2020;
FI: 3,632; Q2
Advances in the diagnosis of ocular toxoplasmosis: Use of optical coherence tomography
ANNALS OF PEDIATRICS, 2020;
FI: 1,313; Q3
Enhancement of immune response mediated by oropharyngeal colostrum administration in preterm neonates.
PEDIATRIC ALLERGY AND IMMUNOLOGY, 2019;
FI: 4,654; D1
The Immunomodulatory Properties of Propyl-Propane Thiosulfonate Contribute to its Intestinal Anti-Inflammatory Effect in Experimental Colitis
MOLECULAR NUTRITION & FOOD RESEARCH, 2019;
FI: 4,653; D1
Intestinal epithelial deletion of the glucocorticoid receptor NR3C1 alters expression of inflammatory mediators and barrier function
FASEB JOURNAL, 2019;
FI: 5,391; D1
Maternal and Neonatal Hair Cortisol Levels Are Associated with Infant Neurodevelopment at Six Months of Age
JOURNAL OF CLINICAL MEDICINE, 2019;
FI: 5,688; D1
Transcriptional Profiling of Dendritic Cells in a Mouse Model of Food-Antigen-Induced Anaphylaxis Reveals the Upregulation of Multiple Immune-Related Pathways
MOLECULAR NUTRITION & FOOD RESEARCH, 2019;
FI: 4,653; D1
Choledochoduodenal Fistula Secondary to Ulcer Disease Presenting With Gastrointestinal Bleeding
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 2018;
FI: 7,683; D1
Calprotectin protects against experimental colonic inflammation in mice
BRITISH JOURNAL OF PHARMACOLOGY, 2018;
FI: 6,81; D1
Immunomodulatory tetracyclines shape the intestinal inflammatory response inducing mucosal healing and resolution
BRITISH JOURNAL OF PHARMACOLOGY, 2018;
FI: 6,81; D1
Potential Role of Seaweed Polyphenols in Cardiovascular-Associated Disorders
MARINE DRUGS, 2018;
FI: 4,379; D1
Lactobacillus fermentum Improves Tacrolimus-Induced Hypertension by Restoring Vascular Redox State and Improving eNOS Coupling
MOLECULAR NUTRITION & FOOD RESEARCH, 2018;
FI: 5,151; D1
Hepatic Hydatid Cysts Causing Biliary Obstruction
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 2017;
FI: 7,398; D1
A synbiotic composed of Lactobacillus fermentum CECT5716 and FOS prevents the development of fatty acid liver and glycemic alterations in rats fed a high fructose diet associated with changes in the microbiota
MOLECULAR NUTRITION & FOOD RESEARCH, 2017;
FI: 4,323; D1
Differential intestinal anti-inflammatory effects of Lactobacillus fermentum and Lactobacillus salivarius in DSS mouse colitis: impact on microRNAs expression and microbiota composition.
MOLECULAR NUTRITION & FOOD RESEARCH, 2017;
FI: 4,323; D1
Immunomodulatory properties of Olea europaea leaf extract in intestinal inflammation
MOLECULAR NUTRITION & FOOD RESEARCH, 2017;
FI: 4,323; D1
Metformin for Obesity in Prepubertal and Pubertal Children: A Randomized Controlled Trial
PEDIATRICS, 2017;
FI: 5,705; D1
Antiinflammatory and immunomodulatory activity of an ethanolic extract from the stem bark of Terminalia catappa L. (Combretaceae): In vitro and in vivo evidences
JOURNAL OF ETHNOPHARMACOLOGY, 2016;
FI: 3,055; D1
Germ-free and Antibiotic-treated Mice are Highly Susceptible to Epithelial Injury in DSS Colitis
JOURNAL OF CROHNS & COLITIS, 2016;
FI: 6,585; D1
Intestinal anti-inflammatory effects of Passiflora edulis peel in the dextran sodium sulphate model of mouse colitis
JOURNAL OF FUNCTIONAL FOODS, 2016;
FI: 3,973; D1
The glucocorticoid budesonide has protective and deleterious effects in experimental colitis in mice
BIOCHEMICAL PHARMACOLOGY, 2016;
FI: 5,091; D1
Anti-inflammatory activity of hydroalcoholic extracts of Lavandula dentata L. and Lavandula stoechas L.
JOURNAL OF ETHNOPHARMACOLOGY, 2016;
FI: 3,055; D1
Pea (Pisum sativum L.) seed albumin extracts show anti-inflammatory effect in the DSS model of mouse colitis
MOLECULAR NUTRITION & FOOD RESEARCH, 2015;
FI: 4,603; D1
The small intestinal mucosa acts as a rutin reservoir to extend flavonoid anti-inflammatory activity in experimental ileitis and colitis
JOURNAL OF FUNCTIONAL FOODS, 2015;
FI: 3,574; D1
Antihypertensive effects of probiotics Lactobacillus strains in spontaneously hypertensive rats
MOLECULAR NUTRITION & FOOD RESEARCH, 2015;
FI: 4,603; D1
A new therapeutic association to manage relapsing experimental colitis: Doxycycline plus Saccharomyces boulardii
PHARMACOLOGICAL RESEARCH, 2015;
FI: 4,408; Q1
Diagnostic screening for subclinical celiac disease using a rapid test in children aged 2-4
PEDIATRIC RESEARCH, 2015;
FI: 2,314; Q1
INTEGRAL MULTIOMIC APPROACH IN THE PREDICTION OF PHARMACOLOGICAL RESPONSE TO THE TREATMENT OF INFLAMMATORY BOWEL DISEASE.
Funder: UNIVERSITY OF GRANADA
File number: C-CTS-342-UGR23
Execution time: 01/01/2024 - 31/12/2025
PI: ALBA RODRIGUEZ NOGALES
Modulation of Intestinal Stromal Cell Homeostasis by the Gut Microbiome: Impact on Inflammatory Bowel Disease and Colorectal Cancer
Funder: CARLOS III HEALTH INSTITUTE - FEDER
File number: PI22 / 01630
Execution time: 01/01/2023 - 31/12/2025
PI: MARIA ELENA RODRIGUEZ CABEZAS
The microbiome as a modulable and predictive factor in the treatment of obesity: impact of nutritional implementation with probiotics and prebiotics (MicoBeBioticos).
Funder: COUNCIL OF ECONOMIC TRANSFORMATION, INDUSTRY, KNOWLEDGE AND UNIVERSITIES
File number: PY20_01157
Execution time: 01/06/2021 - 31/12/2022
PI: ALBA RODRIGUEZ NOGALES
Non-tissue-specific alkaline phosphatase as a nutritional and pharmacological target in inflammation and intestinal barrier function
Funder: COUNCIL OF ECONOMIC TRANSFORMATION, INDUSTRY, KNOWLEDGE AND UNIVERSITIES
File number: PY20_00695
Execution time: 04/10/2021 - 30/06/2023
IP: OLGA MARTINEZ AUGUSTIN
Discovery of new functions of human milk and non-tissue-specific alkaline phosphatase
Funder: STATE RESEARCH AGENCY
File number: PID2020-120140RB-I00
Execution time: 01/09/2021 - 31/08/2024
IP: OLGA MARTINEZ AUGUSTIN
Integration of a biomarker screening system; inside a commercial miRNA analysis device. Characterization of miRNA profiles as tumor phenotype markers and development of a predictive model of response to treatment in cancer
Funder: COUNCIL OF HEALTH AND FAMILIES
File number: PIP-0236-2021
Execution time: 10/12/2021 - 09/12/2023
IP: ANGEL CARAZO GALLEGO
Optimization of the therapy of diseases that compromise the intestinal barrier function (sepsis; acute pancreatitis; COVID19) with glucocorticoids minimizing their epithelial actions (EPICORT)
Funder: CARLOS III HEALTH INSTITUTE - FEDER
File number: PI21 / 00952
Execution time: 01/01/2021 - 31/12/2023
PI: FERMIN SANCHEZ DE MEDINA LOPEZ-HUERTAS
Development of a prognostic and predictive model of response to treatment in colorectal cancer based on the immunological context of the tumor
Funder: CARLOS III HEALTH INSTITUTE - FEDER
File number: PI21 / 01378
Execution time: 01/01/2022 - 31/12/2024
IP: ANGEL CARAZO GALLEGO
Alkaline phosphatase as a therapeutic and nutritional target in inflammatory and metabolic diseases
Funder: UNIVERSITY OF GRANADA
File number: A-AGR-468-UGR20
Execution time: 01/07/2021 - 30/06/2023
PI: FERMIN SANCHEZ DE MEDINA LOPEZ-HUERTAS
PI20 / 01447 - New insights in mechanism underlying immediate reactions induced by amoxicillin and clavulanic acid for improving diagnosis
Funder: CARLOS III HEALTH INSTITUTE - FEDER
File number: PI20 / 01447
Execution time: 01/01/2021 - 31/12/2023
PI: ALBA RODRIGUEZ NOGALES
INFLAMMATION, BOWEL BARRIER FUNCTION AND METABOLIC SYNDROME. MODULATION BY FUNCTIONAL FOODS
Funder: MINISTRY OF ECONOMY AND COMPETITIVENESS
File number: AGL2014-58883-R
Execution time: 01/01/2015 - 31/12/2017
IP: OLGA MARTINEZ AUGUSTIN
REGULATION OF THE BOWEL BARRIER FUNCTION BY CORTICOIDS, CALPROTECTIN, AND THE SODIUM-HYDROGEN EXCHANGER NHE3
Funder: MINISTRY OF ECONOMY AND COMPETITIVENESS
File number: BFU2014-57736-P
Execution time: 01/01/2015 - 31/12/2017
PI: FERMIN SANCHEZ DE MEDINA LOPEZ-HUERTAS
Therapeutic Potential of Mesenchymal Stromal Cell Derived Exosomes in Intestinal Inflammation
Funder: COUNCIL OF HEALTH
File number: PI-0206-2016
Execution time: 01/01/2017 - 31/12/2019
PI: MARIA ELENA RODRIGUEZ CABEZAS
ALBINO - Effect of ALlopurinol in addition to hypothermia for hypoxic-ischemic Brain Injury on Neurocognitive Outcme - a blinded randomized placebo-controlled multicenter trial
Funder: EUROPEAN COMMISSION
File number: EECC-667224
Execution time: 07/12/2017 - 07/12/2022
PI: JOSE ANTONIO HURTADO SUAZO
Epidemiological study of pediatric allergic diseases in Spain.
Funder: SPANISH SOCIETY OF CLINICAL IMMUNOLOGY, ALLERGY AND PEDIATRIC ASTHMA (SEICAP)
Type of test: OBSERVATIONAL STUDY WITH MEDICATION
Execution time: 20/11/2023 - 30/03/2025
IP: Epidemiological study of pediatric allergic diseases in Spain.
Study of the Advantages of Using Autologous Platelet-Rich Fibrin Matrix (Obsidian ASG) for the Treatment of Anastomoses in Rectal Operations: A Randomized, Multicenter, Single-Blind Pilot Study
Financier: VIVOSTAT A/S
Type of test: INV. CLINICA PRODUCT SANITARIO COM.
Execution time: 25/05/2022 - 30/08/2023
IP: JORGE RAMOS SANFIEL
Observational and open study in children and adolescents with severe asthma with eosinophilic phenotype treated with mepolizumab. CASAM study.
Funder: SPANISH SOCIETY OF PEDIATRIC PNEUMOLOGY
Type of test: INDEPENDENT POST-AUTHORIZATION STUDY
Execution time: 20/10/2021 - 30/10/2025
IP: Observational and open study in children and adolescents with severe asthma with eosinophilic phenotype treated with mepolizumab. CASAM study.
Analysis of the effectiveness and safety of switching from original to biosimilar adalimumab in patients with inflammatory bowel disease
Financer: PEREZ
Type of test: INDEPENDENT POST-AUTHORIZATION STUDY
Execution time: 25/06/2021 - 30/12/2021
IP: MARIA DEL MAR MARTIN RODRIGUEZ
Targeted oxygenation in the respiratory care of preterm infants at the time of delivery: effects on developmental outcome. TORPIDO STUDY 30/60.
Funder: THE UNIVERSITY OF SYDNEY
Type of test: INDEPENDENT CLINICAL TRIAL
Execution time: 13/01/2021 - 30/12/2023
PI: JOSE ANTONIO HURTADO SUAZO
Ursodeoxycholic acid vs placebo for the prevention of recurrent acute biliary pancreatitis. Randomized, multicenter, double-blind, placebo-controlled clinical trial.
Financer: DE MANDARIA
Type of test: INDEPENDENT CLINICAL TRIAL
Execution time: 01/02/2021 - 30/03/2021
IP: ANTONIO MARIA CABALLERO MATEOS
Phase II, open-label, uncontrolled, single-dose study to evaluate the safety, tolerability and pharmacokinetics, and the development of anti-drug antibodies to nirsevimab in immunocompromised children ≥24 months of age
Funder: ASTRAZENECA AB
Type of test: COMMERCIAL CLINICAL TRIAL
Execution time: 27/09/2021 - 30/05/2023
IP: JUAN LUIS SANTOS PEREZ
A Phase 2b Randomized, Double-Blind, Placebo-controlled Study to Evaluate the Safety and Efficacy of MEDI8897, a Monoclonal Antibody With an Extended Half-life Against Respiratory Syncytial Virus, in Healthy Preterm Infants
Funder: MEDIMMUNE LLC
Type of test: COMMERCIAL CLINICAL TRIAL
Execution time: 09/06/2017 - 31/12/2019
PI: JOSE ANTONIO HURTADO SUAZO