MP16-Intestinal Immunomodulation

Intestinal inflammation marker calprotectin regulates intestinal epithelial zinc metabolism and proliferation in mouse jejunal organoids

BIOMEDICINE & PHARMACOTHERAPY, 2024;

FI: 6,9; D1

Melatonin decreases human adipose tissue insulin sensitivity

JOURNAL OF PINEAL RESEARCH, 2024;

FI: 8,3; D1

The glucocorticoid receptor potentiates aldosterone- induced transcription by the mineralocorticoid receptor

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2024;

FI: 9,4; D1

Bismuth-based drugs sensitize Pseudomonas aeruginosa to multiple antibiotics by disrupting iron homeostasis

NATURE MICROBIOLOGY, 2024;

FI: 20,5; D1

Differential Modulation of Mouse Intestinal Organoids with Fecal Luminal Factors from Obese, Allergic, Asthmatic Children

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2024;

FI: 4,9; Q1

Administration of intestinal mesenchymal stromal cells reduces colitis-associated cancer in C57BL/6J mice modulating the immune response and gut dysbiosis

PHARMACOLOGICAL RESEARCH, 2023;

FI: 9,3; D1

Performance of the New ABC and MAP(ASH) Scores in the Prediction of Relevant Outcomes in Upper Gastrointestinal Bleeding

JOURNAL OF CLINICAL MEDICINE, 2023;

FI: 3,9; Q2

Non-obstructive jaundice as paraneoplastic syndrome of prostate carcinoma: Systematic review of published cases

CLINICAL MEDICINE, 2023;

FI: 3,9; Q2

Minocycline Prevents the Development of Key Features of Inflammation and Pain in DSS-induced Colitis in Mice

JOURNAL OF PAIN, 2023;

FI: 4; Q2

Risk factors for functional dyspepsia, erosive and non-erosive gastroesophageal reflux disease: A cross-sectional study

GASTROENTEROLOGY AND HEPATOLOGY, 2023;

FI: 1,9; Q4

Modulation of intestinal barrier function by glucocorticoids: Lessons from preclinical models

PHARMACOLOGICAL RESEARCH, 2022;

FI: 10,334; D1

The Antioxidant Activity of Thymus serpyllum Extract Protects against the Inflammatory State and Modulates Gut Dysbiosis in Diet-Induced Obesity in Mice

ANTIOXIDANTS, 2022;

FI: 7,675; D1

The melatonergic agonist agomelatine ameliorates high fat diet-induced obesity in mice through the modulation of the gut microbiome

BIOMEDICINE & PHARMACOTHERAPY, 2022;

FI: 7,419; D1

A New Calcium Vectoring Technology: Concentration and Distribution of Ca and Agronomic Efficiency in Pepper Plants

AGRONOMY-BASEL, 2022;

FI: 3,949; Q1

A Standardized Extract of Lentinula edodes Cultured Mycelium Inhibits Pseudomonas aeruginosa Infectivity Mechanisms

FRONTIERS IN MICROBIOLOGY, 2022;

FI: 6,064; Q1

ABC score: a new risk score that accurately predicts mortality in acute upper and lower gastrointestinal bleeding: an international multicenter study

GUT, 2021;

FI: 23,059; D1

A Gastroenterologist' clinical experience in COVID 19 and in-hospital mortality and length of stay analysis.

POSTGRADUATE MEDICINE, 2021;

FI: 3,84; Q1

A recombinant glucocorticoid-induced leucine zipper protein ameliorates symptoms of dextran sulfate sodium-induced colitis by improving intestinal permeability

FASEB JOURNAL, 2021;

FI: 5,192; Q1

Allium-Derived Compound Propyl Propane Thiosulfonate (PTSO) Attenuates Metabolic Alterations in Mice Fed a High-Fat Diet through Its Anti-Inflammatory and Prebiotic Properties.

NUTRIENTS, 2021;

FI: 5,719; Q1

Changes in gastric emptying of digestible solids in professional cyclists: relationship with exercise intensity

SPANISH JOURNAL OF DIGESTIVE DISEASES, 2021;

FI: 2,086; Q4

Changes to the gut microbiota induced by losartan contributes to its antihypertensive effects

BRITISH JOURNAL OF PHARMACOLOGY, 2020;

FI: 7,73; D1

Anti-Inflammatory and Chemopreventive Effects of Bryophyllum pinnatum (Lamarck) Leaf Extract in Experimental Colitis Models in Rodents

FRONTIERS IN PHARMACOLOGY, 2020;

FI: 4,225; Q1

Circadian Rhythms in Hormone-sensitive Lipase in Human Adipose Tissue: Relationship to Meal Timing and Fasting Duration

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2020;

FI: 5,399; Q1

MAP (ASH): A new scoring system for the prediction of intervention and mortality in upper gastrointestinal bleeding

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2020;

FI: 3,632; Q2

Advances in the diagnosis of ocular toxoplasmosis: Use of optical coherence tomography

ANNALS OF PEDIATRICS, 2020;

FI: 1,313; Q3

Enhancement of immune response mediated by oropharyngeal colostrum administration in preterm neonates.

PEDIATRIC ALLERGY AND IMMUNOLOGY, 2019;

FI: 4,654; D1

The Immunomodulatory Properties of Propyl-Propane Thiosulfonate Contribute to its Intestinal Anti-Inflammatory Effect in Experimental Colitis

MOLECULAR NUTRITION & FOOD RESEARCH, 2019;

FI: 4,653; D1

Intestinal epithelial deletion of the glucocorticoid receptor NR3C1 alters expression of inflammatory mediators and barrier function

FASEB JOURNAL, 2019;

FI: 5,391; D1

Maternal and Neonatal Hair Cortisol Levels Are Associated with Infant Neurodevelopment at Six Months of Age

JOURNAL OF CLINICAL MEDICINE, 2019;

FI: 5,688; D1

Transcriptional Profiling of Dendritic Cells in a Mouse Model of Food-Antigen-Induced Anaphylaxis Reveals the Upregulation of Multiple Immune-Related Pathways

MOLECULAR NUTRITION & FOOD RESEARCH, 2019;

FI: 4,653; D1

Choledochoduodenal Fistula Secondary to Ulcer Disease Presenting With Gastrointestinal Bleeding

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 2018;

FI: 7,683; D1

Calprotectin protects against experimental colonic inflammation in mice

BRITISH JOURNAL OF PHARMACOLOGY, 2018;

FI: 6,81; D1

Immunomodulatory tetracyclines shape the intestinal inflammatory response inducing mucosal healing and resolution

BRITISH JOURNAL OF PHARMACOLOGY, 2018;

FI: 6,81; D1

Potential Role of Seaweed Polyphenols in Cardiovascular-Associated Disorders

MARINE DRUGS, 2018;

FI: 4,379; D1

Lactobacillus fermentum Improves Tacrolimus-Induced Hypertension by Restoring Vascular Redox State and Improving eNOS Coupling

MOLECULAR NUTRITION & FOOD RESEARCH, 2018;

FI: 5,151; D1

Hepatic Hydatid Cysts Causing Biliary Obstruction

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 2017;

FI: 7,398; D1

A synbiotic composed of Lactobacillus fermentum CECT5716 and FOS prevents the development of fatty acid liver and glycemic alterations in rats fed a high fructose diet associated with changes in the microbiota

MOLECULAR NUTRITION & FOOD RESEARCH, 2017;

FI: 4,323; D1

Differential intestinal anti-inflammatory effects of Lactobacillus fermentum and Lactobacillus salivarius in DSS mouse colitis: impact on microRNAs expression and microbiota composition.

MOLECULAR NUTRITION & FOOD RESEARCH, 2017;

FI: 4,323; D1

Immunomodulatory properties of Olea europaea leaf extract in intestinal inflammation

MOLECULAR NUTRITION & FOOD RESEARCH, 2017;

FI: 4,323; D1

Metformin for Obesity in Prepubertal and Pubertal Children: A Randomized Controlled Trial

PEDIATRICS, 2017;

FI: 5,705; D1

Antiinflammatory and immunomodulatory activity of an ethanolic extract from the stem bark of Terminalia catappa L. (Combretaceae): In vitro and in vivo evidences

JOURNAL OF ETHNOPHARMACOLOGY, 2016;

FI: 3,055; D1

Germ-free and Antibiotic-treated Mice are Highly Susceptible to Epithelial Injury in DSS Colitis

JOURNAL OF CROHNS & COLITIS, 2016;

FI: 6,585; D1

Intestinal anti-inflammatory effects of Passiflora edulis peel in the dextran sodium sulphate model of mouse colitis

JOURNAL OF FUNCTIONAL FOODS, 2016;

FI: 3,973; D1

The glucocorticoid budesonide has protective and deleterious effects in experimental colitis in mice

BIOCHEMICAL PHARMACOLOGY, 2016;

FI: 5,091; D1

Anti-inflammatory activity of hydroalcoholic extracts of Lavandula dentata L. and Lavandula stoechas L.

JOURNAL OF ETHNOPHARMACOLOGY, 2016;

FI: 3,055; D1

Pea (Pisum sativum L.) seed albumin extracts show anti-inflammatory effect in the DSS model of mouse colitis

MOLECULAR NUTRITION & FOOD RESEARCH, 2015;

FI: 4,603; D1

The small intestinal mucosa acts as a rutin reservoir to extend flavonoid anti-inflammatory activity in experimental ileitis and colitis

JOURNAL OF FUNCTIONAL FOODS, 2015;

FI: 3,574; D1

Antihypertensive effects of probiotics Lactobacillus strains in spontaneously hypertensive rats

MOLECULAR NUTRITION & FOOD RESEARCH, 2015;

FI: 4,603; D1

A new therapeutic association to manage relapsing experimental colitis: Doxycycline plus Saccharomyces boulardii

PHARMACOLOGICAL RESEARCH, 2015;

FI: 4,408; Q1

Diagnostic screening for subclinical celiac disease using a rapid test in children aged 2-4

PEDIATRIC RESEARCH, 2015;

FI: 2,314; Q1

Impact of the intestinal stroma-microbiome relationship on inflammatory bowel disease and colorectal cancer

Funder: FIBAO Foundation

File number: INTRAIBS-PI-2023-05

Execution time: 05/04/2024 - 05/04/2025

IP: MARIA JOSE RODRIGUEZ SANCHEZ

EVALUATION OF A NEW THERAPEUTIC STRATEGY BASED ON FECAL TRANSPLANT IN PATIENTS WITH INFLAMMATORY BOWEL DISEASE TREATED WITH IMMUNOTHERAPY.

Funder: CARLOS III HEALTH INSTITUTE - FEDER

File number: PI24 / 02089

Execution time: 01/01/2025 - 31/12/2027

PI: ALBA RODRIGUEZ NOGALES

INTEGRAL MULTIOMIC APPROACH IN THE PREDICTION OF PHARMACOLOGICAL RESPONSE TO THE TREATMENT OF INFLAMMATORY BOWEL DISEASE.

Funder: UNIVERSITY OF GRANADA

File number: C-CTS-342-UGR23

Execution time: 01/01/2024 - 31/12/2025

PI: ALBA RODRIGUEZ NOGALES

Modulation of Intestinal Stromal Cell Homeostasis by the Gut Microbiome: Impact on Inflammatory Bowel Disease and Colorectal Cancer

Funder: CARLOS III HEALTH INSTITUTE - FEDER

File number: PI22 / 01630

Execution time: 01/01/2023 - 31/12/2025

PI: MARIA ELENA RODRIGUEZ CABEZAS

The microbiome as a modulable and predictive factor in the treatment of obesity: impact of nutritional implementation with probiotics and prebiotics (MicoBeBioticos).

Funder: COUNCIL OF ECONOMIC TRANSFORMATION, INDUSTRY, KNOWLEDGE AND UNIVERSITIES

File number: PY20_01157

Execution time: 01/06/2021 - 31/12/2022

PI: ALBA RODRIGUEZ NOGALES

Non-tissue-specific alkaline phosphatase as a nutritional and pharmacological target in inflammation and intestinal barrier function

Funder: COUNCIL OF ECONOMIC TRANSFORMATION, INDUSTRY, KNOWLEDGE AND UNIVERSITIES

File number: PY20_00695

Execution time: 04/10/2021 - 30/06/2023

IP: OLGA MARTINEZ AUGUSTIN

Discovery of new functions of human milk and non-tissue-specific alkaline phosphatase

Funder: STATE RESEARCH AGENCY

File number: PID2020-120140RB-I00

Execution time: 01/09/2021 - 31/08/2024

IP: OLGA MARTINEZ AUGUSTIN

Integration of a biomarker screening system; inside a commercial miRNA analysis device. Characterization of miRNA profiles as tumor phenotype markers and development of a predictive model of response to treatment in cancer

Funder: COUNCIL OF HEALTH AND FAMILIES

File number: PIP-0236-2021

Execution time: 10/12/2021 - 09/12/2023

IP: ANGEL CARAZO GALLEGO

Optimization of the therapy of diseases that compromise the intestinal barrier function (sepsis; acute pancreatitis; COVID19) with glucocorticoids minimizing their epithelial actions (EPICORT)

Funder: CARLOS III HEALTH INSTITUTE - FEDER

File number: PI21 / 00952

Execution time: 01/01/2021 - 31/12/2023

PI: FERMIN SANCHEZ DE MEDINA LOPEZ-HUERTAS

Development of a prognostic and predictive model of response to treatment in colorectal cancer based on the immunological context of the tumor

Funder: CARLOS III HEALTH INSTITUTE - FEDER

File number: PI21 / 01378

Execution time: 01/01/2022 - 31/12/2024

IP: ANGEL CARAZO GALLEGO

Alkaline phosphatase as a therapeutic and nutritional target in inflammatory and metabolic diseases

Funder: UNIVERSITY OF GRANADA

File number: A-AGR-468-UGR20

Execution time: 01/07/2021 - 30/06/2023

PI: FERMIN SANCHEZ DE MEDINA LOPEZ-HUERTAS

PI20 / 01447 - New insights in mechanism underlying immediate reactions induced by amoxicillin and clavulanic acid for improving diagnosis

Funder: CARLOS III HEALTH INSTITUTE - FEDER

File number: PI20 / 01447

Execution time: 01/01/2021 - 31/12/2023

PI: ALBA RODRIGUEZ NOGALES

INFLAMMATION, BOWEL BARRIER FUNCTION AND METABOLIC SYNDROME. MODULATION BY FUNCTIONAL FOODS

Funder: MINISTRY OF ECONOMY AND COMPETITIVENESS

File number: AGL2014-58883-R

Execution time: 01/01/2015 - 31/12/2017

IP: OLGA MARTINEZ AUGUSTIN

REGULATION OF THE BOWEL BARRIER FUNCTION BY CORTICOIDS, CALPROTECTIN, AND THE SODIUM-HYDROGEN EXCHANGER NHE3

Funder: MINISTRY OF ECONOMY AND COMPETITIVENESS

File number: BFU2014-57736-P

Execution time: 01/01/2015 - 31/12/2017

PI: FERMIN SANCHEZ DE MEDINA LOPEZ-HUERTAS

Therapeutic Potential of Mesenchymal Stromal Cell Derived Exosomes in Intestinal Inflammation

Funder: COUNCIL OF HEALTH

File number: PI-0206-2016

Execution time: 01/01/2017 - 31/12/2019

PI: MARIA ELENA RODRIGUEZ CABEZAS

ALBINO - Effect of ALlopurinol in addition to hypothermia for hypoxic-ischemic Brain Injury on Neurocognitive Outcme - a blinded randomized placebo-controlled multicenter trial

Funder: EUROPEAN COMMISSION

File number: EECC-667224

Execution time: 07/12/2017 - 07/12/2022

PI: JOSE ANTONIO HURTADO SUAZO

AIRIS Crohn Registry. Assessing the Impact of RISankizumab on clinical outcomes and biomarkers in Crohns Disease.

Funder: Alejandro Otero Foundation for Biosanitary Research of Eastern Andalusia (FIBAO)

Test type: OBSERVATIONAL STUDY WITH MEDICINES

Execution time: 07/06/24 - 30/06/26

IP: ANTONIO MARIA CABALLERO MATEOS

A prospective, post-authorization, international study of UPadacitinib to evaluate its rapid onset and durability of effectiveness in real-world clinical practice in patients with moderate to severe Crohn's disease over 3 years (UPlift)

Funder: ABBVIE SPAIN SLU

Test type: OBSERVATIONAL STUDY WITH MEDICINES

Execution time: 01/04/2024 - 30/09/2028

IP: MARIA DEL MAR MARTIN RODRIGUEZ

Study of the Advantages of Using Autologous Platelet-Rich Fibrin Matrix (Obsidian ASG) for the Treatment of Anastomoses in Rectal Operations: A Randomized, Multicenter, Single-Blind Pilot Study

Financier: VIVOSTAT A/S

Type of test: INV. CLINICA PRODUCT SANITARIO COM.

Execution time: 25/05/2022 - 30/08/2023

IP: JORGE RAMOS SANFIEL

Observational and open study in children and adolescents with severe asthma with eosinophilic phenotype treated with mepolizumab. CASAM study.

Funder: SPANISH SOCIETY OF PEDIATRIC PNEUMOLOGY

Type of test: INDEPENDENT POST-AUTHORIZATION STUDY

Execution time: 20/10/2021 - 30/10/2025

IP: Observational and open study in children and adolescents with severe asthma with eosinophilic phenotype treated with mepolizumab. CASAM study.

Analysis of the effectiveness and safety of switching from original to biosimilar adalimumab in patients with inflammatory bowel disease

Financer: PEREZ

Type of test: INDEPENDENT POST-AUTHORIZATION STUDY

Execution time: 25/06/2021 - 30/12/2021

IP: MARIA DEL MAR MARTIN RODRIGUEZ

Targeted oxygenation in the respiratory care of preterm infants at the time of delivery: effects on developmental outcome. TORPIDO STUDY 30/60.

Funder: THE UNIVERSITY OF SYDNEY

Type of test: INDEPENDENT CLINICAL TRIAL

Execution time: 13/01/2021 - 30/12/2023

PI: JOSE ANTONIO HURTADO SUAZO

Ursodeoxycholic acid vs placebo for the prevention of recurrent acute biliary pancreatitis. Randomized, multicenter, double-blind, placebo-controlled clinical trial.

Financer: DE MANDARIA

Type of test: INDEPENDENT CLINICAL TRIAL

Execution time: 01/02/2021 - 30/03/2021

IP: ANTONIO MARIA CABALLERO MATEOS

Phase II, open-label, uncontrolled, single-dose study to evaluate the safety, tolerability and pharmacokinetics, and the development of anti-drug antibodies to nirsevimab in immunocompromised children ≥24 months of age

Funder: ASTRAZENECA AB

Type of test: COMMERCIAL CLINICAL TRIAL

Execution time: 27/09/2021 - 30/05/2023

IP: JUAN LUIS SANTOS PEREZ

A Phase 2b Randomized, Double-Blind, Placebo-controlled Study to Evaluate the Safety and Efficacy of MEDI8897, a Monoclonal Antibody With an Extended Half-life Against Respiratory Syncytial Virus, in Healthy Preterm Infants

Funder: MEDIMMUNE LLC

Type of test: COMMERCIAL CLINICAL TRIAL

Execution time: 09/06/2017 - 31/12/2019

PI: JOSE ANTONIO HURTADO SUAZO