MP15-Liver Diseases and Colorectal Cancer
Precision Medicine / IBS-MP15
Multidisciplinary group made up of clinical researchers (specialists in Digestive, Radiation Oncology and General Surgery and of the Digestive System) and basic researchers oriented towards the study of liver diseases associated with obesity and liver and colorectal cancer.
Research lines
- Application of nanotechnology to the manufacture of massive sequencing libraries with reduced cost and biases, analysis of circulating miRNAs with reduced cost and increased efficiency and improved flow cytometry applied to tissue
- Cancer stem cells in relation to the tumor niche in colorectal and liver cancer
- Development of new treatments for cancer
- Cancer immune avoidance
- Pathophysiology of oxidative stress
- Obesity: Analysis of adipose tissue cell populations in relation to fatty liver disease in morbid obesity
- Immune function of adipose tissue and its implication in the development of type 2 diabetes mellitus and other pathologies associated with obesity
- Immune memory in viral infections: hepatitis C and B, cytomegalovirus and SARS-CoV-2
- Immune function of adipose tissue and its implication in the development of type 2 diabetes mellitus and other pathologies associated with obesity
- Immune memory in viral infections: hepatitis C and B, cytomegalovirus and SARS-CoV-2
Keywords
Obesity, diabetes, NAFLD, cancer stem cells, tumor niche, ROS / RNS, nanotechnology
JOSE DAVID BRIDGES PARDO
ADELINA GARCIA ROBLES
DAVID LOPEZ PEREZ
ALICIA MARTIN-LAGOS MALDONADO
MARIA SOL ZURITA SAAVEDRA
JESUS GARCIA RUBIO
MARIA GARCIA COSTELA
ANA GILA MEDINA
CRISTINA GONZALEZ PUGA
JOSEPH LEON LOPEZ
FRANCISCO DAVID MARTIN OLIVA
SANDRA MARTIN MARTIN GUERRERO
MARIA DEL PILAR MARTINEZ TIRADO
ESTHER OCETE HITA
ANAIS REDRUELLO ROMERO
JULIA ESCUDERO FELIU
Degree: Method of obtaining useful data to predict or predict vertical transmission, chronification and / or clearance of the hepatitis C virus.
Code: PCT / ES2016 / 07115
Inventors: Ángeles Ruiz Extremera; Esther J. Pavón Castillero; Javier Salmerón Escobar; Paloma Muñoz de Rueda; José Antonio Muñoz Gámez; Jorge Casado Ruiz; Ángel Carazo Gallego; Rosa Quiles Pérez; Ana Gila Medina; Josefa León López; Ana B Martín Álvarez; Sergio Manuel Jim
Degree: Method of obtaining useful data to predict or predict vertical transmission of the hepatitis C virus
Code: P201530221
Inventors: Ángeles Ruiz Extremera; Esther J. Pavón Castillero; Javier Salmerón Escobar; Paloma Muñoz de Rueda; José Antonio Muñoz Gámez; Jorge Casado Ruiz; Ángel Carazo Gallego; Rosa Quiles Pérez; Ana Gila Medina; Josefa León López; Ana B Martín Álvarez; Sergio Manuel Jim
Degree: Method of obtaining useful data to predict or predict hepatitis C chronification and HCV clearance
Code: P201530222
Inventors: MIGUEL ANGEL LOPEZ NEVOT, JOSEFA LEON LOPEZ, ANA GILA MEDINA, JOSÉ ANTONIO MUÑOZ GÁMEZ, ROSA QUILES PÉREZ, PALOMA MUÑOZ DE RUEDA, ÁNGEL CARAZO GALLEGO, ESTHER JOSÉ PAVÓN CASTILLERO, ANA BELÉNIO MUÑOZ SALMON ESCO
Degree: POLYMORPHISMS TO PREDICT OR FORECAST THE RESPONSE TO ANTIVIRAL TREATMENT
Code: P201430205
Inventors: JAVIER SALMERÓN ESCOBAR; PALOMA MUÑOZ DE RUEDA; ROSA QUILES PÉREZ; JOSE ANTONIO MUÑOZ GAMEZ; ESTHER JOSÉ PAVÓN CASTILLERO; ANA GILA MEDINA; MIGUEL ANGEL LOPEZ NEVOT; JORGE CASADO RUIZ; ANGELES RUIZ LEIZÓN EXTREMERA; ANA GILA CARRENO ANGELES;
Degree: Specific mutations (L5P; L7P; L15S) in the immunodominant epitope HCV-NS3 (aa 1253-1272) against HLA-DQB1 * 0301 cause a non-response to antiviral treatment with pegIFN / RBV in patients with Chronic Hepatitis C genotype
Code: P-06781
In Obese Patients With Type 2 Diabetes, Mast Cells in Omental Adipose Tissue Decrease the Surface Expression of CD45, CD117, CD203c, and Fc epsilon RI
FRONTIERS IN ENDOCRINOLOGY, 2022;
FI: 6,055; Q1
Microglia and Microglia-Like Cells: Similar but Different
FRONTIERS IN CELLULAR NEUROSCIENCE, 2022;
FI: 6,147; Q1
Switching Roles: Beneficial Effects of Adipose Tissue-Derived Mesenchymal Stem Cells on Microglia and Their Implication in Neurodegenerative Diseases
BIOMOLECULES, 2022;
FI: 6,064; Q2
Therapeutic approaches for digestive system cancers and potential implications of exercise under hypoxia condition: what little is known? a narrative review
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 2022;
FI: 4,322; Q2
Wandering liver as a cause of intestinal obstruction
GASTROENTEROLOGY AND HEPATOLOGY, 2022;
FI: 5,867; Q2
Adipose Tissue Redox Microenvironment as a Potential Link between Persistent Organic Pollutants and the 16-Year Incidence of Non-hormone-Dependent Cancer
ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2021;
FI: 9,028; D1
Associations of persistent organic pollutants in human adipose tissue with retinoid levels and their relevance to the redox microenvironment..
ENVIRONMENTAL RESEARCH, 2021;
FI: 6,498; D1
Cosmetic and personal care product use, urinary levels of parabens and benzophenones, and risk of endometriosis: results from the EndEA study.
ENVIRONMENTAL RESEARCH, 2021;
FI: 6,498; D1
Core Circadian Clock Proteins as Biomarkers of Progression in Colorectal Cancer
BIOMEDICINE, 2021;
FI: 6,081; Q1
Endothelin-1 as a Mediator of Heme Oxygenase-1-Induced Stemness in Colorectal Cancer: Influence of p53
JOURNAL OF PERSONALIZED MEDICINE, 2021;
FI: 4,945; Q1
PARP-1 activation after oxidative insult promotes energy stress-dependent phosphorylation of YAP1 and reduces cell viability
BIOCHEMICAL JOURNAL, 2020;
FI: 4,097; Q2
Adipose tissue concentrations of non-persistent environmental phenols and local redox balance in adults from Southern Spain
ENVIRONMENT INTERNATIONAL, 2019;
FI: 7,943; D1
Contribution of sociodemographic, occupational, lifestyle and dietary characteristics to the oxidative stress microenvironment in adipose tissue.
ENVIRONMENTAL RESEARCH, 2019;
FI: 5,026; D1
Exploring the radiosensitizing potential of magnetotherapy: a pilot study in breast cancer cells
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 2019;
FI: 2,266; D1
Poly (ADP-Ribose) Polymerase-1 inhibition potentiates cell death and phosphorylation of DNA damage response proteins in oxidative stressed retinal cells
EXPERIMENTAL EYE RESEARCH, 2019;
FI: 2,998; Q1
An Overview of the Polymorphisms of Circadian Genes Associated With Endocrine Cancer
FRONTIERS IN ENDOCRINOLOGY, 2019;
FI: 3,634; Q2
Impact of comorbidities on patient outcomes after interferon-free therapy-induced viral eradication in hepatitis C.
Journal of Hepatology, 2018;
FI: 15,04; D1
Cytometric analysis of adipose tissue reveals increases of adipocyte progenitor cells after weight loss induced by bariatric surgery
SCIENTIFIC REPORTS, 2018;
FI: 4,122; Q1
Narrow-leafed lupine (Lupinus angustifolius L.) seed -conglutins reverse the induced insulin resistance in pancreatic cells
FOOD & FUNCTION, 2018;
FI: 3,289; Q1
The SELGIFS data challenge: generating synthetic observations of CALIFA galaxies from hydrodynamic simulations
MONTHLY NOTICES OF THE ROYAL ASTRONOMICAL SOCIETY, 2018;
FI: 5,194; Q1
Admission, discharge and triage guidelines for pediatric intensive care units in Spain
ANNALS OF PEDIATRICS, 2018;
FI: 1,318; Q3
Treatment of Hepatitis C Virus Infection in Patients With Cirrhosis and Predictive Value of Model for End-Stage Liver Disease: Analysis of Data From the Hepa-C Registry
HEPATOLOGY, 2017;
FI: 13,246; D1
Poly (ADP-ribose) polymerases inhibitors prevent early mitochondrial fragmentation and hepatocyte cell death induced by H2O2
PLOSONE, 2017;
FI: 2,806; Q1
The antigenic variability of HCV in viral HLA-Ag binding is related to the activation of the host immune response
SCIENTIFIC REPORTS, 2017;
FI: 4,259; Q1
Analysis of Immunogenetic Factors in Idiosyncratic Drug-induced Liver Injury in the Pediatric Population.
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, 2017;
FI: 2,799; Q1
Influence of HLA class I, HLA class II and KIRs on vertical transmission and chronicity of hepatitis C virus in children.
PLOSONE, 2017;
FI: 2,806; Q1
Contribution of Persistent Organic Pollutant Exposure to the Adipose Tissue Oxidative Microenvironment in an Adult Cohort: A Multipollutant Approach
ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2016;
FI: 5,393; D1
Hepatitis C during pregnancy, vertical transmission and new treatment possibilities
CLINICAL MEDICINE, 2016;
FI: 1,267; Q2
High-Resolution Hepatitis C Virus Subtyping Using NS5B Deep Sequencing and Phylogeny, an Alternative to Current Methods (vol 53, pg 219, 2015)
JOURNAL OF CLINICAL MICROBIOLOGY, 2016;
FI: 3,631; Q2
Effects of manual therapy on treatment duration and motor development in infants with severe nonsynostotic plagiocephaly: a randomized controlled pilot study
CHILD'S NERVOUS SYSTEM, 2016;
FI: 1,08; Q3
Repercussions of plagiocephaly on posture, muscle flexibility and balance in children aged 3-5 years old
JOURNAL OF PEDIATRICS AND CHILD HEALTH, 2016;
FI: 1,477; Q3
Synergistic cytotoxicity of the poly (ADP-ribose) polymerase inhibitor ABT-888 and temozolomide in dual-drug targeted magnetic nanoparticles
LIVER INTERNATIONAL, 2015;
FI: 4,85; Q1
High-Resolution Hepatitis C Virus Subtyping Using NS5B Deep Sequencing and Phylogeny, an Alternative to Current Methods
JOURNAL OF CLINICAL MICROBIOLOGY, 2015;
FI: 3,993; Q1
Valproic acid modulates radiation-enhanced matrix metalloproteinase activity and invasion of breast cancer cells.
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 2015;
FI: 1,687; Q1
Fine-mapping butyrophilin family genes revealed several polymorphisms influencing viral genotype selection in hepatitis C infection.
GENES AND IMMUNITY, 2015;
FI: 2,913; Q2
Effectiveness and safety of first-generation protease inhibitors in clinical practice: Hepatitis C virus patients with advanced fibrosis.
WORLD JOURNAL OF GASTROENTEROLOGY, 2015;
FI: 2,369; Q3
A multi-omics stratification and a non-invasive tool for the early diagnosis of patients with triple-negative and Her2+ breast cancer who respond to neoadjuvant therapy
Funder: INSTITUTO DE SALUD CARLOS III
File number: AC22 / 00031
Execution time: 01/01/2023 - 31/12/2025
IP: JOSEFA LEON LOPEZ
Relationship of Pre-Adipocyte Populations and the Immune Infiltrate of Adipose Tissue With Nonalcoholic Fatty Liver Disease in Morbidly Obese Patients.
Funder: FUNDACION PUBLICA ANDALUZA PROGRESO Y SALUD
File number: PI-0515-2014
Execution time: 31/07/2015 - 30/09/2017
Validation study of biomarkers associated both with increased risk of mother-to-child HCV transmission and with increased risk of persistent HCV infection in children vertically transmitted.
Funder: GILEAD SCIENCES INTERNATIONAL LTD.
File number: GLD15-00307
Execution time: 01/03/2016 - 01/03/2017
Relationship of pre-adipocyte populations and the immune infiltrate of adipose tissue with nonalcoholic fatty liver disease in morbidly obese patients
Funder: INSTITUTO DE SALUD CARLOS III
File number: PI15 / 01361
Execution time: 01/01/2016 - 31/12/2018
Epidemiological, immunogenetic and metabolomic characterization of hepatotoxicity in the pediatric population
Funder: INSTITUTO DE SALUD CARLOS III
File number: PI17 / 01989
Execution time: 01/01/2018 - 31/12/2020
PI: ESTHER OCETE HITA
Study of the evolution of tumor heterogeneity derived from tumor stem cells and infiltrated immune cells during rectal cancer treatment and its relationship with recurrence.
Funder: INSTITUTO DE SALUD CARLOS III
File number: PI18 / 01947
Execution time: 01/01/2019 - 31/12/2021
Impact of telemonitoring in the management of complex inflammatory bowel disease in Spain: a multicenter TECCU study
Funder: SPANISH WORKING GROUP ON CROHN'S DISEASE AND ULCEROUS COLITIS
Type of test: INV. INDEP SANITARY PRODUCT CLINIC.
Execution time: 23/01/2020 - 30/01/2022
PI: MARIA DEL PILAR MARTINEZ TIRADO
Multicenter, randomized, double-blind, placebo-controlled study of the efficacy and safety of LJPC-501 in pediatric patients> 2 to 17 years of age with catecholamine-resistant hypotension associated with distributive shock.
Funder: LA JOLLA PHARMACEUTICAL COMPANY
Type of test: COMMERCIAL CLINICAL TRIAL
Execution time: 04/12/2018 - 30/05/2021
PI: ESTHER OCETE HITA