MP13-Antiretroviral Resistances

Information
Members
Publications
Projects
Clinical trials

The group coordinates the Spanish HIV Research Network Work Package on subtypes and resistance and contributes with several European organizations on HIV resistance (ESAR-SPREAD, Eurocord-CHAIN, EuRESIST-INTEGRATE) and hepatitis resistance (SHARED, HEPCARE). The group has been actively involved in recent research on Transmitted Drug Resistance in Spain and Europe, on genotypic investigation on HIV viral Tropism, on clinical significance of HIV low and very low-level viraemia, and on molecular epidemiology of HIV ti guide public helath interventions . The group is actively involved in hepatitis C virus research activities, coordinating several activities in GEHEP (Spanish Viral Hepatitis Study Group of the Clinical Microbiology & Infectious diseases Spanish Society), and coordinator of HEPCRESP, the Spanish national cohort on HCV resistance to new DAAs. The group is also in the Sterring Comittee of HEPCARE (Europe) and SHARED (Global) hepatitis

Research lines

Elimination of viral hepatitis
Molecular epidemiology of HIV and hepatitis
Microbiota, probiotics, immunity and disease
Antibiotic resistance and alternative therapy
Resistance to antiretrovirals
smRNA and infection
G-quadruplex as a therapeutic target
Molecular surveillance of bacterial pathogens
Antimicrobials for the food industry

Research networks

RIS - Spanish Network for AIDS Research
CIBERINFEC - Biomedical Research Network Center for Infectious Diseases

Keywords

HIV, Hepatitis C, Microbiota.

RUBEN CEBRIAN CASTLE

ANGEL CARAZO GALICIAN

ORCID

Mª DOLORES MERIDA DEL CANO

JOSE ANTONIO SANCHEZ ALVAREZ

MARTA ALVAREZ ESTEVEZ

ORCID

NATALIA CHUECA PORCUNA

ORCID

ADOLFO DE SALAZAR GONZALEZ

ORCID

ANA SOURCES LOPEZ

ORCID

FEDERICO GARCIA GARCIA

FERNANDO GARCIA GARCIA

JOSEFA LOPEZ BUENO

Camelo-Castillo, A; Madrid, TJ; Fernández, TC; Rodríguez-Maresca, M; Carazo, AD; Carrodeguas, A; Medina, D; García, F; Casado-Martín, M

Opportunistic screening for hepatitis C virus infection in an emergency department in Almeria, Spain

EMERGENCIES, 2024;

FI: 5,4; D1

Xia, Y.S.; Wei, XY; Gao, P; Wang, C.Y.; de Jong, A; Chen, J.H.K.; Rodriguez-Sanchez, MJ; Rodríguez-Nogales, A; Diez-Echave, P; Gálvez, J; García, F; Wu, W.H.; Kao, RYT; Li, H.Y.; Cebrián, R; Kuipers, O.P.; Sun, H.Z.

Bismuth-based drugs sensitize Pseudomonas aeruginosa to multiple antibiotics by disrupting iron homeostasis

NATURE MICROBIOLOGY, 2024;

FI: 20,5; D1

Valero-Ubierna, Maria del Carmen; Benavente-Fernandez, Alberto; de Rojas, Javier Perez; Moreno-Verdejo, Fidel; Lopez-Gomez, Jairo; Fernandez-Ontiveros, Sergio; Chueca-Porcuna, Natalia; Garcia-Marin, Cristina; Jimenez-Moleon, Jose Juan; Rivera-Izquierdo, Mario

Social and clinical predictors of perianal colonization by multidrug-resistant bacteria for geriatric patients in the internal medicine service

INFECTION, 2024;

FI: 5,4; Q1

Camacho-Cardenosa, A; Clavero-Jimeno, A; Martin-Olmedo, JJ; Amaro-Gahete, F; Cupeiro, R; Cejudo, MTG; Pérez, PVG; Hernández-Martinez, C; Sevilla-Lorente, R; De-la-O, A; López-Vázquez, A; Molina-Fernandez, M; Carneiro-Barrera, A; Garcia, F; Rodríguez-Nogales, A; Peralta, JJG; Head, R; Martín-Rodríguez, JL; Muñoz-Garach, A; Muñoz-Torres, M; Labayen, I; Ruiz, JR

Time-restricted eating and supervised exercise for improving hepatic steatosis and cardiometabolic health in adults with obesity: protocol for the TEMPUS randomized controlled trial

BMJ OPEN, 2024;

FI: 2,4; Q1

Giammarino, F; de Salazar, A; Malet, I; Viñuela, L; Fuentes, A; Saladini, F; Bartolini, N; Charpentier, C; Lambert-Niclot, S; Sterrantino, G; Colao, MG; Micheli, V; Bertoli, A; Fabeni, L; Teyssou, E; Delgado, R; Falces-Romero, I; Aguilera, A; Gomes, P; Paraskevis, D; Santoro, MM; Ceccherini-Silberstein, F; Marcelin, AG; Moreno, C; Zazzi, M; Garcia, F.

Prevalence and Phenotypic Susceptibility to Doravirine of the HIV-1 Reverse Transcriptase V106I Polymorphism in B and Non-B Subtypes

JOURNAL OF INFECTIOUS DISEASES, 2024;

FI: 5; Q1

Moreno-SanJuan, S; Casado, J; Escudero-Feliu, J; Khaldy, H; Arnedo, J; Carazo, A; Leon, J

Agomelatine, a Melatonin-Derived Drug, as a New Strategy for the Treatment of Colorectal Cancer

ANTIOXIDANTS, 2023;

FI: 7; Q1

Fuentes, A; Abu-Dayyeh, I; de Salazar, A; Khasharmeh, R; Al-Shabatat, F; Jebrin, S; Chueca, N; Hamdan, FM; Albtoush, Y; Abu Al-Shaer, O; Rashid, M.M.; Almohsen, O; Al-Jbour, M; Abdelnour, A; Garcia, F.

Molecular characterization of patients with chronic hepatitis C virus infection in Jordan: implications on response to direct-acting antiviral therapy

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, 2023;

FI: 8,4; Q1

Redruello-Romero, A; Benitez-Cantos, MS; Lopez-Perez, D; Garcia-Rubio, J; Tamayo, F; Perez-Bartivas, D; Moreno-SanJuan, S; Ruiz-Palmero, I; Puentes-Pardo, JD; Vilchez, JR; Lopez-Nevot, MA; Garcia, F; Cano, C; Leon, J; Carazo, A

Human adipose tissue as a major reservoir of cytomegalovirus-reactive T cells

FRONTIERS IN IMMUNOLOGY, 2023;

FI: 7,3; Q1

Garcia-Garcia, J; Diez-Echave, P; Yuste, ME; Chueca, N; Garcia, F; Cabeza-Barrera, J; Fernandez-Varon, E; Galvez, J; Colmenero, M; Rodriguez-Cabezas, ME; Rodriguez-Nogales, A; Moron, R

Gut Microbiota Composition Can Predict Colonization by Multidrug-Resistant Bacteria in SARS-CoV-2 Patients in Intensive Care Unit: A Pilot Study

ANTIBIOTICS-BASEL, 2023;

FI: 4,8; Q2

Garcia-Ceberino, PM; Salazar-Gonzalez, A; Faro-Miguez, N; Fuentes-Lopez, A; Viñuela-Gonzalez, L; Palomares-Rodriguez, J; Valero-Ubierna, C; Ruiz-Villaverde, R; Garcia-Garcia, F; Hernandez-Quero, J; Ruiz-Sancho, A.L.

Monkeypox Virus Infection and Sexually Transmitted Infections: A Cross-Sectional Study from a Secondary Hospital in the May-September 2022 International Outbreak

AIDS RESEARCH AND HUMAN RETROVIRUSES, 2023;

FI: 1,5; Q4

Fragkou, P.C.; De Angelis, G; Menchinelli, G; Can, FS; Garcia, F; Morfin-Sherpa, F; Dimopoulou, D; Mack, E; de Salazar, A; Grossi, A; Lytras, T; Skevaki, C.

ESCMID COVID-19 guidelines: diagnostic testing for SARS-CoV-2

CLINICAL MICROBIOLOGY AND INFECTION, 2022;

FI: 13,31; D1

Serrano-Conde, E; Leyva, A; Fuentes, A; de Salazar, A; Chueca, N; Perez-Castro, S; Regueiro, B; Rojas, A; Mendoza, J; Rojas, J; Garcia, F.

In vitro neutralizing activity of BNT162b2 mRNA-induced antibodies against full B.1.351 SARS-CoV-2 variant

TRANSBOUNDARY AND EMERGING DISEASES, 2022;

FI: 4,521; D1

Fernandez-Fuertes, M; Corma-Gomez, A; Torres, E; Rodriguez-Pineda, E; Fuentes-Lopez, A; Rincon, P; Fernandez, N; Garcia, F; Bernal, S; Real, LM; Macias, J; Pineda, J.A.

Incidence of and factors associated with SARS-CoV-2 infection among people living with HIV in Southern Spain after one year of pandemic

TRANSBOUNDARY AND EMERGING DISEASES, 2022;

FI: 4,521; D1

Rivero-Juarez, A; Frias, M; Perez, AB; Pineda, JA; Queen, G; Fuentes-Lopez, A; Freyre-Carrillo, C; Ramirez-Arellano, E; Alados, JC; Rivero, A.

Orthohepevirus C infection as an emerging cause of acute hepatitis in Spain: First report in Europe

Journal of Hepatology, 2022;

FI: 30,083; D1

Corma-Gomez, A; Fernandez-Fuertes, M; Garcia, E; Fuentes-Lopez, A; Gomez-Ayerbe, C; Rivero-Juarez, A; Dominguez, C; Santos, M; Vinuela, L; Palacios, R; Real, LM; Rivero, A; Macias, J; Pineda, JA; Garcia, F.

Severe immunosuppression is related to poorer immunogenicity to SARS-CoV-2 vaccines among people living with HIV

CLINICAL MICROBIOLOGY AND INFECTION, 2022;

FI: 13,31; D1

Nakanishi, T.; Pigazzini, S; Degenhardt, F; Cordioli, M; Butler-Laporte, G; Maya-Miles, D; Bujanda, L.; Bouysran, Y; Niemi, MEK; Dove; Ellinghaus, D; Khan, A; Martinez-Bueno, M; Rolker, S; Amitrano, S; Tato, L.R.; Fava, F; Spinner, CD; Prati, D; Bernard,

Age-dependent impact of the major common genetic risk factor for COVID-19 on severity and mortality

JOURNAL OF CLINICAL RESEARCH, 2021;

FI: 14,808; D1

Vezza, T.; Garrido-Mesa, J; Diez-Echave, P; Hidalgo-Garcia, L; Ruiz-Malagon, AJ; Garcia, F.; Sanchez, M.; Toral, M; Romero, M.; Duarte, J.; Guillamon, E; Banos, A; Moron, R.; Galvez, J.; Rodriguez-Nogales, A; Rodriguez-Cabezas, ME

Allium-Derived Compound Propyl Propane Thiosulfonate (PTSO) Attenuates Metabolic Alterations in Mice Fed a High-Fat Diet through Its Anti-Inflammatory and Prebiotic Properties.

NUTRIENTS, 2021;

FI: 5,719; Q1

Velazquez-Suarez, C; Cebrian, R; Gasca-Capote, C; Sorlozano-Puerto, A; Gutierrez-Fernandez, J; Martinez-Bueno, M; Maqueda, M; Valdivia, E.

Antimicrobial Activity of the Circular Bacteriocin AS-48 against Clinical Multidrug-Resistant Staphylococcus aureus.

ANTIBIOTICS-BASEL, 2021;

FI: 4,639; Q2

Sources, A.; Serrano-Conde, E; Roldán, C; Benito-Ruesca, R; Mejias, G.; Sampedro, A; March-Rosello, G; Fernandez-Natal, I; Esperalba, J; Rodriguez, MJ; deAguirre, PM; Rooms, C; Roc, ML; Soria, LM; Parra-Grande, M; Montero, M.D.; Fernandez-Roblas, R; of Moon,

Antibody response in patients admitted to the hospital with suspected SARS-CoV-2 infection: results from a multicenter study across Spain

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, 2021;

FI: 3,267; Q3

Barrientos-Duran, A; de Salazar, A; Fuentes-Lopez, A; Serrano-Conde, E; Swordfork, B; Chueca, N.; Alvarez-Estevez, M; Garcia, F.

Comparison between Aptima (R) assays (Hologic) and the CoBAS (R) 6800 system (Roche) for the diagnosis of sexually transmitted infections caused by Chlamydia trachomatis, Neisseria gonorrhoeae, and Mycoplasma genitalium

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, 2021;

FI: 3,267; Q3

Gomez-Llorente, MA; Martinez-Canavate, A; Chueca, N; Rich, M.D.; Romero, R; Anguita-Ruiz, A; Aguilera, C.M.; Gil-Campos, M; Mesa, M.D.; Khakimov, B; Morillo, J.A.; Gil, A; Camacho, J; Gomez-Llorente, C.

A Multi-Omics Approach Reveals New Signatures in Obese Allergic Asthmatic Children

BIOMEDICINE, 2020;

FI: 4,717; Q1

Peris-Torres, C; Plaza-Calonge, MD; Lopez-Dominguez, R; Dominguez-Garcia, S; Barrientos-Duran, A; Carmona-Saez, P; Rodriguez-Manzaneque, JC

Extracellular Protease ADAMTS1 Is Required at Early Stages of Human Uveal Melanoma Development by Inducing Stemness and Endothelial-Like Features on Tumor Cells

CANCER, 2020;

FI: 6,126; Q1

Barrientos-Duran, A; de Salazar, A; Alvarez-Estevez, M; Fuentes-Lopez, A; Espadafor, B; Garcia, F.

Detection of sexually transmitted disease-causing pathogens from direct clinical specimens with the multiplex PCR-based STD Direct Flow Chip Kit

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, 2020;

FI: 2,837; Q2

Lopez-Martinez, J; Chueca, N; Padial-Molina, M; Fernandez-Caballero, JA; Garcia, F; O'Valle, F; Galindo-Moreno, P

Bacteria associated with periodontal disease are also increased in health

ORAL MEDICINE ORAL PATHOLOGY AND ORAL SURGERY, 2020;

FI: 1,596; Q3

Aguilera, A; Winged, JC; Alonso, R; Eiros, JM; Garcia, F.

Current position of viral load versus hepatitis C core antigen testing

INFECTIOUS DISEASES AND CLINICAL MICROBIOLOGY, 2020;

FI: 1,654; Q4

Vrancken, B; Cuypers, L; Perez, AB; Chueca, N; Anton-Basantas, J; of the Church, A; Fuentes, J; Pineda, JA; Tellez, F; Bernal, E; Rincon, P; Von Wichman, MA; Fuentes, A; Vera, F; Rivero-Juarez, A; Jimenez, M; Vandamme, AM; Garcia, F

Cross-country migration linked to people who inject drugs challenges the long-term impact of national HCV elimination programs

Journal of Hepatology, 2019;

FI: 18,946; D1

Alvarez, M; Houses, P; de Salazar, A; Chueca, N; Guerrero-Beltran, C; Rodriguez, C; Imaz, A; Espinosa, N; Garcia-Bujalance, S; Perez-Elias, MJ; Garcia-Alvarez, M; Iribarren, JA; Santos, J; Dalmau, D; Aguilera, A; Vinuesa, D; Gutierrez, F; Pierola, B; Molina, JM; Peraire, J; Porthole, I; Gomez-Sirvent, JL; Olalla, J; Galera, C; White, JR; Riera, M; Garcia-Fraile, L; Navarro, G; Curran, A; Poveda, E; Garcia, F; Moreno, S; Jarrin, I; Dalmau, D; Navarro, ML; Gonzalez, MI; White, JL; Garcia, F; Rubio, R; Iribarren, JA; Gutierrez, F; Vidal, F; Berenguer, J; Gonzalez, J; Alejos, B; Hernando, V; Moreno, C; Iniesta, C; Sousa, LMG; Perez, NS; Munoz-Fernandez, MA; Garcia-Merino, IM; Fernandez, IC; Rico, CG; de la Fuente, JG; Council, PP

Surveillance of transmitted drug resistance to integrate inhibitors in Spain: implications for clinical practice

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2019;

FI: 5,113; D1

Perez, AB; Chueca, N; Garcia-Deltoro, M; Martinez-Sapina, AM; Lara-Perez, MM; Garcia-Bujalance, S; Aldamiz-Echevarria, T; Vera-Mendez, FJ; Pineda, JA; Married, M; Pascasio, JM; Salmeron, J; Alados-Arboledas, JC; Poyato, A; Tellez, F; Rivero-Juarez, A; Merino, D; Vivancos-Gallego, MJ; Rosales-Zabal, JM; Garcia, F; Ocete, MD; Simon, MA; Rincon, P; Reus, S; Of the Church, A; Garcia-Arata, I; Jimenez, M; Jimenez, F; Hernandez-Quero, J; Galera, C; Balghata, MO; Primo, J; Masia, M; Espinosa, N; Delgado, M; von-Wichmann, MA; Collado, A; Santos, J; Minguez, C; Diaz-Flores, F; Fernandez, E; Bernal, E; De Juan, J; Anton, JJ; Velez, M; Aguilera, A; Navarro, D; Arenas, JI; Fernandez, C; Espinosa, MD; Rios, MJ; Alonso, R; Hidalgo, C; Hernandez, R; Tellez, MJ; Rodriguez, FJ; Antequera, P; Delgado, C; Martin, P; Crespo, J; Becerril, B; Perez, O; Garcia-Herola, A; Montero, J; Freyre, C; Grau, C

High efficacy of resistance-guided treatment of HCV patients failing NS5A inhibitors in the real world

Journal of Hepatology, 2019;

FI: 18,946; D1

Macias, J; Morano, LE; Tellez, F; Granados, R; Rivero-Juarez, A; Palacios, R; Rios, MJ; Merino, D; Perez-Perez, M; Collado, A; Figueruela, B; Morano, A; Freyre-Carrillo, C; Martin, JM; Rivero, A; Garcia, F; Pineda, J.A.

Response to direct-acting antiviral therapy among ongoing drug users and people receiving opioid substitution therapy.

Journal of Hepatology, 2019;

FI: 18,946; D1

Requena, S; Lozano, AB; Knight, E; Garcia, F; Nieto, MC; Tellez, R; Fernandez, JM; Wheat, M; Rodriguez-Avial, I; Martin-Carbonero, L; Miralles, P; Soriano, V; de Mendoza, C; Rodriguez, C; Vera, M; del Romero, J; Marcaide, G; Ocete, MD; Knight, E; Aguilera, A; Benito, R; from Lejarazu, RO; Red, S; Eiros, JM; Ramos, C; Garcia, J; Peace, I; Wheat, M; Diz, J; Garcia-Campello, M; Rodriguez-Iglesias, M; Hernandez-Betancor, A; Martin, AM; Ramos, JM; Gimeno, A; Sanchez, V; Gomez-Hernando, C; Cilla, G; Perez-Trallero, E; Fernandez-Pereira, L; Niubo, J; Hernandez, M; Lopez-Lirola, AM; Gomez-Sirvent, JL; Force, L; Cabrera, J; Perez, S; Morano, L; Raya, C; Gonzalez-Praetorius, A; Cifuentes, C; Penaranda, M; Nieto, MC; Montejo, JM; Roc, L; Viciana, I; Lozano, AB; Fernandez-Fuertes, E; Fernandez, JM; Garcia-Bermejo, I; Gaspar, G; Tellez, R; Gorgolas, M; Diaz, J; Miralles, P; Perez, L; Valeiro, M; Aldamiz, T; Margall, N; Suarez, A; Rodriguez-Avial, I; Requena, S; Benitez-Gutierrez, L; Cuervas-Mons, V; de Mendoza, C; Barreiro, P; Soriano, V

Clinical experience with integrase inhibitors in HIV-2-infected individuals in Spain

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2019;

FI: 5,113; D1

Perez-Parra, S; Alvarez, M; Fernandez-Caballero, J.A.; Perez, AB; Santos, J; Bisbal, O; Aguilera, A; Rivero, M; Garcia-Fraile, L; Garcia, F.

Continued spread of the CRF19_cpx variant among HIV-positive MSM patients in Spain

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2018;

FI: 5,217; D1

Sorbo, MC; Cento, V; Di Maio, VC; Howe, AYM; Garcia, F; Bolt, CF; Ceccherini-Silberstein, F

Hepatitis C virus drug resistance associated substitutions and their clinical relevance: Update 2018 (vol 37, pg 17, 2018)

DRUG RESISTANCE UPDATES, 2018;

FI: 11,63; D1

Square, A; Llerena, S; Cobo, C; Pallas, JR; Mateo, M; Cabezas, J; Fortea, JI; Alvarez, S; Pellon, R; Crespo, J; Echevarria, S; Ayesa, R; Setien, E; Lopez-Hoyos, M; Crespo-Facorro, B; Aguero, J; Chueca, N; Garcia, F; Calleja, JL; Crespo, J

Microenvironment Eradication of Hepatitis C: A Novel Treatment Paradigm

AMERICAN JOURNAL OF GASTROENTEROLOGY, 2018;

FI: 10,231; D1

Garrido-Mesa, J; Rodriguez-Nogales, A; Algieri, F; Vezza, T; Hidalgo-Garcia, L; Garrido-Barros, M; Utrilla, MP; Garcia, F; Chueca, N; Rodriguez-Cabezas, ME; Garrido-Mesa, N; Galvez, J.

Immunomodulatory tetracyclines shape the intestinal inflammatory response inducing mucosal healing and resolution

BRITISH JOURNAL OF PHARMACOLOGY, 2018;

FI: 6,81; D1

Cuypers, L; Perez, AB; Chueca, N; Aldamiz-Echevarria, T; Winged, JC; Martinez-Sapina, AM; Merino, D; Pineda, J.A.; Tellez, F; Spiny, N; Salmeron, J; Rivero-Juarez, A; Vivancos, MJ; Hontanon, V; Vandamme, AM; Garcia, F.

Relapse or reinfection after failing hepatitis C direct acting antiviral treatment: Unraveled by phylogenetic analysis

PLOSONE, 2018;

FI: 2,766; Q1

Galindo-Moreno, P; Lopez-Martinez, J; Caba-Molina, M; Rios-Pelegrina, R; Torrecillas-Martinez, L; Monk, A; Table, F; Chueca, N; Garcia-Garcia, F; O'Valle, F

Morphological and immunophenotypical differences between chronic periodontitis and peri-implantitis - a cross-sectional study

EUROPEAN JOURNAL OF ORAL IMPLANTOLOGY, 2017;

FI: 3,567; D1

Rodriguez-Nogales, A; Algieri, F; Garrido-Mesa, J; Vezza, T; Utrilla, MP; Chueca, N; Garcia, F; Olivares, M; Rodriguez-Cabezas, ME; Galvez, J.

Differential intestinal anti-inflammatory effects of Lactobacillus fermentum and Lactobacillus salivarius in DSS mouse colitis: impact on microRNAs expression and microbiota composition.

MOLECULAR NUTRITION & FOOD RESEARCH, 2017;

FI: 4,323; D1

Aguilera, A; Navarro, D; Rodriguez-Frias, F; Viciana, I; Martinez-Sapina, AM; Rodriguez, MJ; Martro, E; Lozano, MC; Coletta, E; Cardenoso, L; Suarez, A; Wheat, M; Rodriguez-Granjer, J; Montiel, N; of the Church, A; Alados, JC; Vegas, C; Bernal, S; Fernandez-Cuenca, F; Pena, MJ; Reina, G; Garcia-Bujalance, S; Echevarria, MJ; Benitez, L; Perez-Castro, S; Ocete, D; Garcia-Arata, I; Guerrero, C; Rodriguez-Iglesias, M; Houses, P; Garcia, F

Prevalence and distribution of hepatitis C virus genotypes in Spain during the 2000-2015 period (the GEHEP 005 study)

JOURNAL OF VIRAL HEPATITIS, 2017;

FI: 4,122; Q1

Perez-Parra, S; Chueca, N; Alvarez, M; Pasquau, J; Omar, M; Collado, A; Vinuesa, D; Lozano, AB; Yebra, G; Garcia, F.

High prevalence and diversity of HIV-1 non-B genetic forms due to immigration in southern Spain: A phylogeographic approach

PLOSONE, 2017;

FI: 2,806; Q1

Masia, M; Padilla, S.; Fernandez, M; Barber, X; Moreno, S; Iribarren, J.A.; Hatch, J; Penalty, A; Vidal, F; Gutierrez, F.

Contribution of Oxidative Stress to Non-AIDS Events in HIV-Infected Patients

JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 2017;

FI: 3,935; Q1

Hermans, LE; Svicher, V; Pas, SD; Salpini, R; Alvarez, M; Ben Ari, Z; Boland, G; Bruzzone, B; Coppola, N; Seguin-Devaux, C; Dyda, T; Garcia, F; Kaiser, R; Kose, S; Krarup, H; Lazarevic, I; Lunar, MM; Maylin, S; Micheli, V; Mor, O; Paraschiv, S; Paraskevis, D; Poljak, M; Puchhammer-Stockl, E; Simon, F; Stanojevic, M; Stene-Johansen, K; Tihic, N; Trimoulet, P; Verheyen, J; Vince, A; Weis, N; Yalcinkaya, T; Lepej, SZ; Bolt, C; Boucher, CAB; Wensing, AMJ

Combined Analysis of the Prevalence of Drug-Resistant Hepatitis B Virus in Antiviral Therapy-Experienced Patients in Europe (CAPRE)

JOURNAL OF INFECTIOUS DISEASES, 2016;

FI: 6,344; D1

Brenner, BG; Thomas, R; White, JL; Ibanescu, RI; Oliveira, M; Mesplede, T; Golubkov, O; Roger, M; Garcia, F; Martinez, E; Wainberg, MA

Development of a G118R mutation in HIV-1 integrase following a switch to dolutegravir monotherapy leading to cross-resistance to integrase inhibitors

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2016;

FI: 4,919; D1

Rojas, J; White, JL; Marcos, MA; Lonca, M; Tricas, A; Moreno, L; Gonzalez-Cordon, A; Torres, B; Mallolas, J; Garcia, F; Gatell, JM; Martinez, E

Dolutegravir monotherapy in HIV-infected patients with sustained viral suppression

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2016;

FI: 4,919; D1

De Luca, A; Flandre, P; Dunn, D; Zazzi, M; Wensing, A; Santoro, MM; Gunthard, HF; Wittkop, L; Kordossis, T; Garcia, F; Castagna, A; Cozzi-Lepri, A; Churchill, D; De Wit, S; Brockmeyer, NH; Imaz, A; Mussini, C; Obel, N; Bolt, CF; Rock, B; Reiss, P; Schulter, E; Torti, C; van Sighem, A; Zangerle, R; Descamps, D

Improved darunavir genotypic mutation score predicting treatment response for patients infected with HIV-1 subtype B and non-subtype B receiving a salvage regimen

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2016;

FI: 4,919; D1

Hofstra, LM; Sauvageot, N; Albert, J; Alexiev, I; Garcia, F; Struck, D; Van de Vijver, DAMC; Asjo, B; Beshkov, D; Coughlan, S; Descamps, D; Griskevicius, A; Hamouda, O; Horban, A; Van Kasteren, M; Kolupajeva, T; Kostrikis, LG; Liitsola, K; Linka, M; Mor, O; Nielsen, C; Otelea, D; Paraskevis, D; Walls, R; Poljak, M; Puchhammer-Stockl, E; Sonnerborg, A; Stanekova, D; Stanojevic, M; Van Laethem, K; Zazzi, M; Lepej, SZ; Boucher, CAB; Schmit, JC; Wensing, AMJ

Transmission of HIV Drug Resistance and the Predicted Effect on Current First-line Regimens in Europe

CLINICAL INFECTIOUS DISEASES, 2016;

FI: 8,736; D1

Monge S; Ten M; Alvarez M; Guillot V; Iribarren JA; Palacios R; Slim R; Jaén A; White JR; Domingo P; Porthole J; Pérez Elías MJ; Garcia F

Use of cohort data to estimate national prevalence of transmitted drug resistance to antiretroviral drugs in Spain (2007-2012)

Clin Microbiol Infect, 2015;

FI: 5,768; D1

Alvarez M; Monge S; Chueca N; Guillot V; Viciana P; Anta L; Rodriguez C; Gomez-Sirvent JL; Navarro G; of the Saints I; Moreno S; Garcia F

Transmitted drug resistance to rilpivirine in newly diagnosed antiretroviral naïve adults

Clin Microbiol Infect, 2015;

FI: 5,768; D1

Doyle, T; Dunn, DT; Ceccherini-Silberstein, F; DeMendoza, C; Garcia, F; Smith, E; Fearnhill, E; Marcelin, AG; Martinez-Picado, J; Kaiser, R; Geretti, AM

Integrase inhibitor (INI) genotypic resistance in treatment-naive and raltegravir-experienced patients infected with diverse HIV-1 clades

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2015;

FI: 5,313; D1

Casadella, M; van Ham, PM; Noguera-Julian, M; van Kessel, A; Pou, C; Hofstra, LM; Santos, JR; Garcia, F; Struck, D; Alexiev, I; Kran, AMB; Hoepelman, AI; Kostrikis, LG; Somogyi, S; Liitsola, K; Linka, M; Nielsen, C; Otelea, D; Paraskevis, D; Poljak, M; Puchhammer-Stockl, E; Stanekova, D; Stanojevic, M; Van Laethem, K; Lepej, SZ; Clotet, B; Boucher, CAB; Walls, R; Wensing, AMJ

Primary resistance to integrate strand-transfer inhibitors in Europe

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2015;

FI: 5,313; D1

Pineda, J.A.; Nunez-Torres, R; Tellez, F; Mancebo, M; Garcia, F; Merchant, N; Perez-Perez, M; Neukam, K; Macias, J; Royal, LM

Hepatitis C virus reinfection after sustained virological response in HIV-infected patients with chronic hepatitis C.

JOURNAL OF INFECTION, 2015;

FI: 4,441; Q1

Interaction between colon cancer microenvironments and peritumoral adipose tissue. Influence on cancer phenotype, progression, and prognosis.

Funder: CARLOS III HEALTH INSTITUTE - FEDER

File number: PI24 / 01834

Execution time: 01/01/2025 - 31/12/2027

IP: ANGEL CARAZO GALLEGO

TF_2024-05 ANGEL CARAZO GALLEGO (MP13)

Funder: FIBAO Foundation

File number: TF_2024-05

Execution time: 14/10/2024 - 31/12/2025

IP: ANGEL CARAZO GALLEGO

MP_PI03_2024 RUBEN CEBRIAN CASTILLO (MP13)

Funder: FIBAO Foundation

File number: MP_PI03_2024

Execution time: 12/12/2024 - 31/12/2025

IP: RUBEN CEBRIAN CASTILLO

ANRS0037: ORIGHAMI – ORIGINE of HIV infection for the Migrant population

Funder: French National Institute for Health and Medical Research – National Agency for Research on AIDS and Viral Hepatitis (INSERM-ANRS)

File number: ORIGHAMI_Federico Garcia

Execution time: 01/03/2022 - 28/02/2025

PI: FEDERICO GARCIA GARCIA

Rapid and Accurate Sepsis Diagnosis Using Next-Generation Sequencing: An Innovative Approach to Optimizing Antibiotic Therapy (RAPIDS-NGS)

Funder: HEALTH AND CONSUMPTION COUNCIL

File number: PI-0220-2024

Execution time: 28/11/2024 - 29/11/2027

IP: ADOLFO DE SALAZAR GONZALEZ

Molecular epidemiological surveillance of Hepatitis Delta virus infection

Funder: SPANISH SOCIETY OF INFECTIOUS DISEASES AND CLINICAL MICROBIOLOGY

File number: GEHEP-2023-AFL

Execution time: 01/01/2024 - 31/12/2024

IP: ANA FUENTES LOPEZ

INFLUENCE OF INTESTINAL MICROBIOTA ON THE SEVERITY OF ACUTE PANCREATITIS (MIGPA)

Funder: UNIVERSITY OF GRANADA

File number: C-CTS-311-UGR23

Execution time: 01/01/2024 - 31/12/2025

PI: NATALIA CHUECA PORCUNA

Consolidation of WGS and RT-PCR activities for SARS-CoV-2 in Spain towards sustainable use and integration of enhanced infrastructure and processes in the RELECOV network RELECOV 2.0

Funder: EUROPEAN COMMISSION

File number: RELECOV 2022

Execution time: 01/07/2023 - 30/06/2025

PI: FEDERICO GARCIA GARCIA

Epidemiological surveillance of the transmission of resistance to antiretrovirals in Spain. Implementation of a real-time transmission cluster study strategy.

Funder: CARLOS III HEALTH INSTITUTE - FEDER

File number: PI22 / 00882

Execution time: 01/01/2023 - 31/12/2025

PI: FEDERICO GARCIA GARCIA

RELECOV 2.0 – Consolidation of WGS and RT-PCR activities for SARS-CoV-2 in Spain towards sustainable use and integration of enhanced infrastructure and processes in the RELECOV network

Funder: EUROPEAN COMMISSION

File number: RELECOV 2022

Execution time: 01/03/2023 - 01/07/2024

PI: FEDERICO GARCIA GARCIA

Development of a commercial kit for massive sequencing of micro RNA, based on an innovative technology with reduced biases (Double Tailing Trap)

Funder: CARLOS III HEALTH INSTITUTE - FEDER

File number: DTS22 / 00151

Execution time: 01/01/2023 - 31/12/2025

IP: ANGEL CARAZO GALLEGO

Characterization of the antibody response to the anti-COVID-19 BNT162b2 vaccine and its determinants

Funder: COUNCIL OF HEALTH AND FAMILIES

File number: PI-0198-2021

Execution time: 10/12/2021 - 09/12/2024

PI: FEDERICO GARCIA GARCIA

Enhancing Whole Genome Sequencing (WGS) and/or ReverseTranscription Polymerase Chain Reaction (RT-PCR) national infrastructures and capacities to respond to the Covid-19 pandemic in Spain.

Funder: EUROPEAN COMMISSION

File number: HERA INCUBATOR 2021

Execution time: 03/09/2021 - 02/10/2022

PI: FEDERICO GARCIA GARCIA

CB21/13/00088 FEDERICO GARCÍA GARCÍA THEMATIC AREA: INFECTIOUS DISEASES

Funder: CARLOS III HEALTH INSTITUTE - FEDER

File number: CB21 / 13/00088

Execution time: 01/01/2022 - 31/12/2025

PI: FEDERICO GARCIA GARCIA

Hepatitis C Microelimination Program in a social integration center.

Funder: GILEAD SCIENCES EUROPE LTD

File number: GILEAD2021-FGG

Execution time: 02/05/2022 - 01/05/2024

PI: FEDERICO GARCIA GARCIA

Towards the elimination of hepatitis C in patients with Serious Mental Disorder

Funder: SPANISH SOCIETY OF INFECTIOUS DISEASES AND CLINICAL MICROBIOLOGY

File number: GEHEP-2020 / FGG

Execution time: 31/12/2020 - 31/12/2021

PI: FEDERICO GARCIA GARCIA

Clinical Relevance and Economic Impact of the Correct Assignment of the Genotype / Subtype of Hepatitis C Virus in the Age of Direct-Acting Antivirals

Funder: FUNDACION PUBLICA ANDALUZA PROGRESO Y SALUD

File number: PI-0411-2014

Execution time: 31/07/2015 - 30/09/2017

IP: MARTA ALVAREZ ESTEVEZ

Virological characterization of patients who do not achieve Sustained Viral Response to treatment with direct-acting antivirals against the hepatitis C virus in interferon-free regimens.

Funder: SPANISH SOCIETY OF INFECTIOUS DISEASES AND CLINICAL MICROBIOLOGY

File number: GEHEP-004-FGG

Execution time: 04/07/2017 - 03/07/2018

PI: FEDERICO GARCIA GARCIA

Virological characterization of patients who do not achieve Sustained Viral Response to treatment with Direct-acting Antivirals against Hepatitis C Virus

Funder: CARLOS III HEALTH INSTITUTE - FEDER

File number: PI15 / 00713

Execution time: 01/01/2016 - 31/12/2018

PI: FEDERICO GARCIA GARCIA

Implementation of a Web Application for Real-Time Monitoring and Characterization of Clusters With High HIV Transmission Rate in Eastern Andalusia

Funder: COUNCIL OF HEALTH

File number: PI-0550-2017

Execution time: 01/01/2018 - 31/12/2020

IP: MARTA ALVAREZ ESTEVEZ

RD16 / 0025/0040 - AIDS NETWORK- FEDERICO GARCÍA GARCÍA

Funder: CARLOS III HEALTH INSTITUTE - FEDER

File number: RD16 / 0025/0040

Execution time: 01/01/2017 - 31/12/2021

PI: FEDERICO GARCIA GARCIA

EPIDEMIOLOGICAL SURVEILLANCE OF PRIMARY AND TRANSMITTED RESISTANCE TO ANTIRETROVIRALS IN SPAIN. PHILOGENETIC, PHILODYNAMIC AND PHILOETHNICAL STUDY

Funder: CARLOS III HEALTH INSTITUTE - FEDER

File number: PI18 / 00819

Execution time: 01/01/2019 - 31/12/2021

PI: FEDERICO GARCIA GARCIA

Study of HIV Seroconverters in the Context of PrEP Use: SCOPE (SeroCOnverters on PrEP) Study

Funder: FUNDACIÓ DE RECERCA CLÍNIC BARCELONA-INSTITUTD'INVESTIGATIONS BIOMÈDIQUES AUGUST PI I SUNYER

Test type: OBSERVATIONAL STUDY WITH MEDICINES

Execution time: 12/12/24 - 30/12/26

IP: ANA FUENTES LOPEZ

CDC- Four-year effectiveness of covid-19 vaccines against severe disease and asymptomatic infection: the covidvac@spain study.

Financing: FOUNDATION FOR BIOMEDICAL RESEARCH OF LA PAZ UNIVERSITY HOSPITAL

Type of test: INDEPENDENT POST-AUTHORIZATION STUDY

Execution time: 31/08/2021 - 31/08/2025

PI: FEDERICO GARCIA GARCIA

National mapping on carbapenemases in Spain. The CARBA-MAP study

Funder: MERCK SHARP & DOHME DE ESPAÑA SA

Type of test: COMMERCIAL POST AUTHORIZATION STUDY

Execution time: 15/10/2020 - 30/09/2021

PI: NATALIA CHUECA PORCUNA

Effectiveness of doxycycline in the negativization of viral replication in COVID-19. Randomized Phase II clinical trial.

Funder: PUBLIC FOUNDATION FOR BIOSANITARY RESEARCH OF ORIENTAL ANDALUCIA ALEJANDRO OTERO (FIBAO)

Type of test: INDEPENDENT CLINICAL TRIAL

Execution time: 04/12/2020 - 31/12/2021

PI: NATALIA CHUECA PORCUNA

MP13-Antiretroviral Resistances

Research lines

Research networks

Keywords

ANA ALBEROLA ROMANO

Alberto Vazquez Blanquiño

MARTA ILLESCAS LOPEZ

LUCIA CHAVES BLANCO

LUCIA PEREZ RODRIGUEZ

ANGELA ALCARAZ MARTINEZ

PALOMA MUÑOZ BAEZ

LAURA VIÑUELA GONZALEZ

RUBEN CEBRIAN CASTLE

ANGEL CARAZO GALICIAN

Mª DOLORES MERIDA DEL CANO

JOSE ANTONIO SANCHEZ ALVAREZ

MARTA ALVAREZ ESTEVEZ

NATALIA CHUECA PORCUNA

ADOLFO DE SALAZAR GONZALEZ

ANA SOURCES LOPEZ

FEDERICO GARCIA GARCIA

FERNANDO GARCIA GARCIA

JOSEFA LOPEZ BUENO

Research