MP11-Rheumatology
Precision Medicine / IBS-MP11
GROUP OBJECTIVE: Delve into the pathogenesis of rheumatoid arthritis. Genetic-molecular bases of rheumatoid arthritis: identification of genetic markers of predisposition and prognosis. To highlight its participation in National and International Projects of competitive financing, Collaboration in different projects with the SER/FER and the SAR/FAR, Collaboration in competitive financing projects with the Institute of Parasitology and Biomedicine López-Neyra (CSIC), with Centro of Genomics and Oncological Research (GENyO) and with the University of Granada.
Research lines
- Biomarkers of prognosis and clinical course
- Gene expression in autoimmune diseases
- Response factors to biological therapies
- Prognostic factors of evolution and therapeutic response
- Cardiovascular morbidity
- Polymorphisms in rheumatoid arthritis
- Cardiovascular risk in autoimmune rheumatological diseases
Research networks
- RIER - Research on Inflammation and Rheumatic Diseases
ISMAEL FRANCISCO AOMAR MILLAN
IMMACULATE JIMENEZ MOLEÓN
PILAR MORALES GARRIDO
ENRIQUE RAYA ALVAREZ
JUAN SALVATIERRA OSSORIO
RICARDO SANCHEZ PARERA
Hospitalization and mortality from COVID-19 of patients with rheumatic inflammatory diseases in Andalusia
CLINICAL RHEUMATOLOGY, 2022;
Dose-Dependent Effect of Melatonin on BAT Thermogenesis in Zucker Diabetic Fatty Rat: Future Clinical Implications for Obesity
ANTIOXIDANTS, 2022;
FI: 7,675; D1
Abatacept in monotherapy vs combined in interstitial lung disease of rheumatoid arthritis-multicentre study of 263 Caucasian patients
RHEUMATOLOGY, 2022;
FI: 7,046; Q1
Biologic therapy in refractory neurobehcet's disease: a multicentre study of 41 patients and literature review
RHEUMATOLOGY, 2022;
FI: 7,046; Q1
Effect of tocilizumab versus standard of care in adults hospitalized with moderate-severe COVID-19 pneumonia
CLINICAL MEDICINE, 2022;
FI: 3,2; Q2
A new molecular classification to drive precision treatment strategies in primary Sjogren's syndrome.
NATURE COMMUNICATIONS, 2021;
FI: 14,919; D1
Integrative Analysis Reveals a Molecular Stratification of Systemic Autoimmune Diseases.
ARTHRITIS & RHEUMATOLOGY, 2021;
FI: 10,995; D1
Anakinra after treatment with corticosteroids alone or with tocilizumab in patients with severe COVID-19 pneumonia and moderate hyperinflammation. A retrospective cohort study
INTERNAL AND EMERGENCY MEDICINE, 2021;
FI: 3,397; Q2
Anakinra after treatment with corticosteroids alone or with tocilizumab in patients with severe COVID-19 pneumonia and moderate hyperinflammation. A retrospective cohort study: reply..
INTERNAL AND EMERGENCY MEDICINE, 2021;
FI: 3,397; Q2
Do all antiphospholipid antibodies confer the same risk for major organ involvement in systemic lupus erythematosus patients?
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, 2021;
FI: 4,473; Q2
Abatacept in interstitial lung disease associated with rheumatoid arthritis: national multicenter study of 263 patients
RHEUMATOLOGY, 2020;
FI: 5,606; Q1
Associated factors to serious infections in a large cohort of juvenile-onset systemic lupus erythematosus from Lupus Registry (RELESSER)
SEMINARS IN ARTHRITIS AND RHEUMATISM, 2020;
FI: 4,751; Q1
Bacteremia in Systemic Lupus Erythematosus in Patients from a Spanish Registry: Risk Factors, Clinical and Microbiological Characteristics, and Outcomes
JOURNAL OF RHEUMATOLOGY, 2020;
FI: 3,35; Q2
Antiphospholipid syndrome (APS) in patients with systemic lupus erythematosus (SLE) implies a more severe disease with more accrual damage and higher mortality
LUPUS, 2020;
FI: 2,251; Q3
Differences in clinical manifestations and increased severity of systemic lupus erythematosus between two groups of Hispanics: European Caucasians versus Latin American mestizos (data from the RELESSER registry)
LUPUS, 2020;
FI: 2,251; Q3
Identification of a 3 '-Untranslated Genetic Variant of RARB Associated With Carotid Intima-Media Thickness in Rheumatoid Arthritis: A Genome-Wide Association Study
ARTHRITIS & RHEUMATOLOGY, 2019;
FI: 9,002; D1
Comparative Study of Infliximab Versus Adalimumab in Refractory Uveitis due to Behcet's Disease: National Multicenter Study of 177 Cases
ARTHRITIS & RHEUMATOLOGY, 2019;
FI: 9,002; D1
Tocilizumab in giant cell arteritis. Observational, open-label multicenter study of 134 patients in clinical practice
SEMINARS IN ARTHRITIS AND RHEUMATISM, 2019;
FI: 5,072; Q1
Evaluation of 12 GWAS-drawn SNPs as biomarkers of rheumatoid arthritis response to TNF inhibitors. A potential SNP association with response to etanercept
PLOSONE, 2019;
FI: 2,776; Q2
Molecular Characterization of Monocyte Subsets Reveals Specific and Distinctive Molecular Signatures Associated With Cardiovascular Disease in Rheumatoid Arthritis
FRONTIERS IN IMMUNOLOGY, 2019;
FI: 4,716; Q2
Cross-phenotype analysis of Immunochip data identifies KDM4C as a relevant locus for the development of systemic vasculitis
ANNALS OF THE RHEUMATIC DISEASES, 2018;
FI: 12,35; D1
Association of a rare variant of the TNFSF13B gene with susceptibility to Rheumatoid Arthritis and Systemic Lupus Erythematosus
SCIENTIFIC REPORTS, 2018;
FI: 4,122; Q1
Validation study of genetic biomarkers of response to TNF inhibitors in rheumatoid arthritis
PLOSONE, 2018;
FI: 2,766; Q1
The beliefs of rheumatoid arthritis patients in their subcutaneous biological drug: strengths and areas of concern.
RHEUMATOLOGY INTERNATIONAL, 2018;
FI: 1,952; Q4
The beliefs of rheumatoid arthritis patients in their subcutaneous biological drugs: strengths and areas of concern (vol 38, pg 1735, 2018)
RHEUMATOLOGY INTERNATIONAL, 2018;
FI: 1,952; Q4
A Genome-wide Association Study Identifies Risk Alleles in Plasminogen and P4HA2 Associated with Giant Cell Arteritis
AMERICAN JOURNAL OF HUMAN GENETICS, 2017;
FI: 9,025; D1
Lipoprotein (a) concentrations in rheumatoid arthritis on biologic therapy: Results from the CARdiovascular in rheuMAtology study project
JOURNAL OF CLINICAL LIPIDOLOGY, 2017;
FI: 5,812; D1
Increased expression of microRNA-155 in peripheral blood mononuclear cells from psoriasis patients is related to disease activity
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY, 2017;
FI: 3,528; Q1
Influence of coronary artery disease and subclinical atherosclerosis related polymorphisms on the risk of atherosclerosis in rheumatoid arthritis.
SCIENTIFIC REPORTS, 2017;
FI: 4,259; Q1
Incidence, associated factors and clinical impact of severe infections in a large, multicentric cohort of patients with systemic lupus erythematosus.
SEMINARS IN ARTHRITIS AND RHEUMATISM, 2017;
FI: 4,498; Q1
IFI44L promoter methylation as a blood biomarker for systemic lupus erythematosus
ANNALS OF THE RHEUMATIC DISEASES, 2016;
FI: 12,384; D1
Influence of elevated-CRP level-related polymorphisms in non-rheumatic Caucasians on the risk of subclinical atherosclerosis and cardiovascular disease in rheumatoid arthritis.
SCIENTIFIC REPORTS, 2016;
FI: 5,228; Q1
Relationship between damage clustering and mortality in systemic lupus erythematosus in early and late stages of the disease: cluster analyzes in a large cohort from the Spanish Society of Rheumatology Lupus Registry
RHEUMATOLOGY, 2016;
FI: 4,524; Q1
Replication of PTPRC as genetic biomarker of response to TNF inhibitors in patients with rheumatoid arthritis
PHARMACOGENOMICS JOURNAL, 2016;
FI: 3,784; Q1
Tacrolimus-induced gynecomastia in a patient with polymyositis
CLINICAL MEDICINE, 2016;
FI: 1,267; Q2
“Prospective, randomized, multicenter study to compare the efficacy at 52 weeks (1 year) of biosimilar teriparatide and alendronate in the prevention of new morphometric vertebral fractures and/or aggravation of previous vertebral fractures in women with clinical vertebral fracture or recent hip fracture (imminent risk of fracture) and low bone mineral density. IMMINENT Study
Financier: GEDEON RICHTER IBÉRICA SA
Type of test: COMMERCIAL CLINICAL TRIAL
Execution time: 14/06/2022 - 30/12/2023
PI: ENRIQUE RAYA ALVAREZ
A multinational, noninterventional study of tofacitinib in patients treated for psoriatic arthritis. TOPSATI. PFI-TOF-2020-01
Financier: PFIZER HOLDING FRANCE
Type of test: OBSERVATIONAL STUDY WITH MEDICATION
Execution time: 03/08/2022 - 30/01/2024
PI: ENRIQUE RAYA ALVAREZ
Evaluation of guselkumab (Tremfya®) and treatment with different IL-17 inhibitors in patients with psoriatic arthritis in routine clinical practice; cohort, observational and prospective study.
Funder: JANSSEN-CILAG INTERNATIONAL NV
Type of test: COMMERCIAL POST AUTHORIZATION STUDY
Execution time: 19/11/2021 - 30/10/2027
PI: ENRIQUE RAYA ALVAREZ
Biological PsA: Retrospective observational study on anti-IL17 treatment patterns in the management of psoriatic arthritis. LIL-IXE-2020-01 (LY2439821)
Financier: LILLY, SA
Type of test: COMMERCIAL POST AUTHORIZATION STUDY
Execution time: 06/10/2020 - 30/01/2021
PI: ENRIQUE RAYA ALVAREZ
Observational study of the persistence of treatment in psoriasic arthritis PRO-SPIRIT study. (LIL-IXE-2019-01)
Funder: ELI LILLY AND COMPANY
Type of test: COMMERCIAL POST AUTHORIZATION STUDY
Execution time: 20/10/2020 - 30/12/2025
PI: ENRIQUE RAYA ALVAREZ