MP09-Neuropharmacology of Pain

Information
Members
Publications
Projects
Clinical trials

The main objectives of the group are to identify new pharmacological targets for pain treatment, to develop new experimental models for the evaluation of pain with translational value, to deepen the knowledge of the neurochemical mechanisms involved in pain, to develop new strategies for the evaluation and treatment of pain. pain in clinic, as well as the determination of various effects of melatonin.

Research lines

EVALUATION OF PAIN AND ANALGESIC PROCEDURES IN HUMANS. RECEPTORS COUPLED TO PROTEINS G
IMPLICATION OF SIGMA1 RECEPTORS IN PAIN PERCEPTION MECHANISMS: Behavioral and biochemical studies in somatic and visceral pain models.
MOLECULAR MECHANISMS OF THE ANTI-OBESITY EFFECT OF MELATONIN IN THE OBESE AND DIABETIC RAT

Research networks

CA23156 - European Network for Sigma-1 Receptor as a Therapeutic Opportunity (SIGMA-1EUROPE)

MIGUEL ANGEL TEJADA GIRALDEZ

ORCID

MAKEYA ADDULJABBAR HASOUN

MIGUEL ANGEL HUERTA MARTINEZ

ORCID

MIRIAM SANTOS KNIGHT

JOSE MANUEL TRAINS FERNANDEZ

EDUARDO FERNANDEZ SEGURA

RAFAEL GALVEZ MATEOS

ORCID

RAFAEL GONZALEZ CANO

MARY IMMACULATE ROSA MONTES RAMIREZ

ORCID

FRANCISCO RAFAEL NIETO LOPEZ

AHMAD AGIL ABDALLA

ANTONIA ARTACHO CORDON

FRANCISCO JAVIER CANIZARES GARCIA

MIGUEL CENDAN MARTINEZ CROSS

ENRIQUE JOSE COBOS DEL MORAL

Jain, A; Gyori, B.M.; Hakim, S; Jain, A; Sun, L; Petrova, V; Bhuiyan, SA; Zhen, S.N.; Wang, Q; Kawaguchi, R; Bunga, S; Taub, D.G.; Ruiz-Cantero, MC; Tong-Li, C; Andrews, N; Kotoda, M; Renthal, W; Sorger, P.K.; Woolf, C.J.

Nociceptor-immune interactomes reveal insult-specific immune signatures of pain

NATURE IMMUNOLOGY, 2024;

FI: 27,8; D1

Huerta, MA; Cisneros, E; Alique, M; Roza, C

Strategies for measuring non-evoked pain in preclinical models of neuropathic pain: Systematic review

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 2024;

FI: 7,6; D1

Santos-Caballero, M; Hasoun, M.A.; Huerta, MA; Ruiz-Cantero, MC; Tejada, MA; Robles-Funes, M; Fernández-Segura, E; Cañizares, FJ; González-Cano, R; Cobos, E.J.

Pharmacological differences in postoperative cutaneous sensitivity, pain at rest, and movement-induced pain in laparotomized mice

BIOMEDICINE & PHARMACOTHERAPY, 2024;

FI: 6,9; D1

Ozdemir, Y; Nakamoto, K; Boivin, B; Bullock, D; Andrews, N.A.; González-Cano, R; Costigan, M.

Quantification of stimulus-evoked tactile allodynia in free moving mice by the chainmail sensitivity test

FRONTIERS IN PHARMACOLOGY, 2024;

FI: 4,4; Q1

Fattori, V; González-Rodríguez, S; González-Cano, R

Editorial: Use of Artificial Intelligence to evaluate drug-related behavioral changes in rodents

FRONTIERS IN PHARMACOLOGY, 2024;

FI: 4,4; Q1

Cuesta-Martínez, S; Ruiz-Leyva, L; Jiménez-García, AM; Aparicio-Mescua, T; López-Guarnido, O; Pautassi, RM; Moron, I; Cendán, CM

Binging from Food to Alcohol: A Sequential Interaction Between Binging Behaviors in Male Wistar Rats

BIO-PROTOCOL, 2023;

Ruiz-Cantero, MC; Huerta, MA; Tejada, MA; Santos-Caballero, M; Fernández-Segura, E; Cañizares, FJ; Train, JM; Baeyens, J.M.; Cobos, E.J.

Sigma-1 receptor agonism exacerbates immune-driven nociception: Role of TRPV1+nociceptors

BIOMEDICINE & PHARMACOTHERAPY, 2023;

FI: 7,5; Q1

Huerta, MA; de la Nava, J; Artacho-Cordón, A; Grandson, F.R.

Efficacy and Safety of Tetrodotoxin in the Treatment of Cancer-Related Pain: Systematic Review and Meta-Analysis

MARINE DRUGS, 2023;

FI: 5,4; Q1

Vezza, T; Molina-Tijeras, JA; Gonzalez-Cano, R; Rodriguez-Nogales, A; Garcia, F; Galvez, J; Cobos, EJ

Minocycline Prevents the Development of Key Features of Inflammation and Pain in DSS-induced Colitis in Mice

JOURNAL OF PAIN, 2023;

FI: 4; Q2

Barrios-Rodriguez, R; Salcedo-Bellido, I; Jimenez-Moleon, JJ; Lozano-Lorca, M; Galiano-Castillo, N; Cobos, EJ; Rein, JDV; Olmedo-Requena, R; Amezcua-Prieto, C; Martin-Pelaez, S; Domenech, CMG; Moreno, JPA; Rica, RA; Garcia-Rubiño, ME; Requena, P

Peer review of teaching: using the nominal group technique to improve a program in a university setting with no previous experience

INTERNATIONAL JOURNAL FOR ACADEMIC DEVELOPMENT, 2023;

FI: 1,3; Q4

Aouichat, S; Raya, E; Molina-Carballo, A; Munoz-Hoyos, A; Aloweidi, AS; Elmahallawy, EK; Agile, A.

Dose-Dependent Effect of Melatonin on BAT Thermogenesis in Zucker Diabetic Fatty Rat: Future Clinical Implications for Obesity.

ANTIOXIDANTS, 2022;

FI: 7,675; D1

Dichiara, M; Artacho-Cordon, A; Turnaturi, R; Santos-Caballero, M; Gonzalez-Cano, R; Pasquinucci, L; Barbaraci, C; Rodriguez-Gomez, I; Gomez-Guzman, M; Marrazzo, A; Cobos, EJ; Amata, E.

Dual Sigma-1 receptor antagonists and hydrogen sulfide-releasing compounds for pain treatment: Design, synthesis, and pharmacological evaluation

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022;

FI: 7,088; D1

Bechthold, E; Schreiber, J.A.; Ritter, N; Grey, L; Schepmann, D; Daniliuc, C; Gonzalez-Cano, R; Nieto, FR; Seebohm, G; Wuensch, B.

Synthesis of tropane-based sigma(1) receptor antagonists with antiallodynic activity

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022;

FI: 7,088; D1

Codony, S; Train, JM; Calvo-Tusell, C; Jora, B; Gonzalez-Cano, R; Osuna, S; Corpas, R; Morisseau, C; Perez, B; Barniol-Xicota, M; Grinan-Ferre, C; Perez, C; Rodriguez-Franco, MI; Martinez, AL; Loza, MI; Pallas, M; Verhelst, S.H.L.; Sanfeliu, C; Feixas, F; Hammock, B.D.; Brea, J; Cobos, EJ; Vazquez, S

Synthesis, In Vitro Profiling, and In Vivo Evaluation of Benzohomoadamantane-Based Ureas for Visceral Pain: A New Indication for Soluble Epoxide Hydrolase Inhibitors

JOURNAL OF MEDICINAL CHEMISTRY, 2022;

FI: 8,039; D1

Zhang, Z.H.; Roberson, D.P.; Kotoda, M; Boivin, B; Bohnslav, J.P.; Gonzalez-Cano, R; Yarmolinsky, D.A.; Turnes, BL; Wimalasena, N.K.; Neufeld, S.Q. Barrett, L.B.; Quintao, NLM; Fattori, V; Taub, D.G.; Wiltschko, AB; Andrews, N.A.; Harvey, C.D.; Datta, S.R.; Woolf, C.J.

Automated preclinical detection of mechanical pain hypersensitivity and analgesia

PAIN, 2022;

FI: 7,926; Q1

Perea, C; Vazquez-Agredos, A; Ruiz-Leyva, L; Morón, I; Zuniga, JM; Cendan, C.M.

Caloric Restriction in Group-Housed Mice: Littermate and Sex Influence on Behavioral and Hormonal Data

FRONTIERS IN VETERINARY SCIENCE, 2021;

FI: 3,412; D1

Kopp, N.; Civenni, G; Marson, D.; Laurini, E; Pricl, S; Catapano, CV; Humpf, HU; Almansa, C; Grandson, F.R.; Schepmann, D; Wunsch, B.

Chemoenzymatic synthesis of 2,6-disubstituted tetrahydropyrans with high sigma(1) receptor affinity, antitumor and analgesic activity

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021;

FI: 6,514; D1

Cortes-Montero, E; Rodriguez-Munoz, M; Ruiz-Cantero, MC; Cobos, EJ; Sanchez-Blazquez, P; Garzon-Nino, J.

Calmodulin Supports TRPA1 Channel Association with Opioid Receptors and Glutamate NMDA Receptors in the Nervous Tissue

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021;

FI: 5,924; Q1

Wilke, J.; Kawamura, T.; Xu, H; Brause, A; Friese, A; Metz, M.; Schepmann, D; Wunsch, B; Artacho-Cordon, A; Grandson, F.R.; Watanabe, N.; Daring, H; Ziegler, S; Waldmann, H.

Discovery of a sigma(1) receptor antagonist by combination of unbiased cell painting and thermal proteome profiling

CELL CHEMICAL BIOLOGY, 2021;

FI: 8,116; Q1

Garcia-Galdeano, JM; Villalon-Mir, M; Medina-Martinez, J; Fonseca-Moor-Davie, SM; Zamora-Bustillos, JG; Vazquez-Foronda, LM; Agile, A; Navarro-Alarcon, M.

Ca and Mg Concentrations in Spices and Growth of Commonly Sporulated and Non-Sporulated Food-Borne Microorganisms According to Marketing Systems

FOODS, 2021;

FI: 4,35; Q2

Diaz, JL; Garcia, M; Torrens, A; Caamano, AM; Enjo, J; Sicre, C; Lorente, A; Port, A; Montero, A; Yeste, S; Alvarez, I; Martin, M; Maldonado, R; de laPuente, B; Vidal-Torres, A; Cendan, C.M.; Sailing, JM; Almansa, C.

EST64454: a Highly Soluble sigma (1) Receptor Antagonist Clinical Candidate for Pain Management

JOURNAL OF MEDICINAL CHEMISTRY, 2020;

FI: 6,205; D1

Aydar, E; Cobos, EJ; Maurice, T.; Murell-Lagnado, RD; Safrany, S.T.

Publisher: Sigma Receptors

FRONTIERS IN PHARMACOLOGY, 2020;

FI: 4,225; Q1

Grandson, FR; Vuckovic, SM; Prostram, MS

Publisher: Mechanisms and New Targets for the Treatment of Chronic Pain

FRONTIERS IN PHARMACOLOGY, 2020;

FI: 4,225; Q1

Agile, A; Chayah, M; Visiedo, L; Navarro-Alarcon, M; Ferrer, JMR; Tassi, M; Reiter, R.J.; Fernandez-Vazquez, G.

Melatonin Improves Mitochondrial Dynamics and Function in the Kidney of Zucker Diabetic Fatty Rats

JOURNAL OF CLINICAL MEDICINE, 2020;

FI: 3,303; Q1

Salguero, A; Suarez, A; Luke, M; Ruiz-Leyva, L; Cendan, C.M.; Moron, I; Pautassi, R.M.

Binge-Like, Naloxone-Sensitive, Voluntary Ethanol Intake at Adolescence Is Greater Than at Adulthood, but Does Not Exacerbate Subsequent Two-Bottle Choice Drinking

FRONTIERS IN BEHAVIORAL NEUROSCIENCE, 2020;

FI: 2,512; Q2

Thum, S; Schepmann, D; Ayet, E; Pujol, M; Grandson, FR; Ametamey, SM; Wunsch, B.

Tetrahydro-3-benzazepines with fluorinated side chains as NMDA and sigma (1) receptor antagonists: Synthesis, receptor affinity, selectivity and antiallodynic activity

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019;

FI: 4,833; D1

Jimenez-Lopez, J; El-Hammadi, MM; Ortiz, R; Cayero-Otero, MD; Head, L; Perazzoli, G; Martin-Banderas, L; Baeyens, JM; Meadows, J; Melguizo, C

A novel nanoformulation of PLGA with high non-ionic surfactant content improves in vitro and in vivo PTX activity against lung cancer

PHARMACOLOGICAL RESEARCH, 2019;

FI: 5,574; D1

Bravo-Caparros, I; Perazzoli, G; Yeste, S; Cikes, D; Baeyens, JM; Cobos, EJ; Grandson, FR

Sigma-1 Receptor Inhibition Reduces Neuropathic Pain Induced by Partial Sciatic Nerve Transection in Mice by Opioid-Dependent and - Independent Mechanisms

FRONTIERS IN PHARMACOLOGY, 2019;

FI: 3,845; Q1

Brown-Hair, AJ; Moon, JDD; Jimenez, FJG; From the Well, E; Canas, EP

Prevalence and risk factors associated with fatal adverse drug reactions among patients admitted at a Spanish teaching hospital

EUROPEAN JOURNAL OF INTERNAL MEDICINE, 2019;

FI: 3,66; Q1

Montilla-Garcia, A; Tejada, MA; Ruiz-Cantero, MC; Bravo-Caparros, I; Yeste, S; Zamanillo, D; Cobos, E.J.

Modulation by Sigma-1 Receptor of Morphine Analgesia and Tolerance: Nociceptive Pain, Tactile Allodynia and Grip Strength Deficits During Joint Inflammation

FRONTIERS IN PHARMACOLOGY, 2019;

FI: 3,845; Q1

Tejada, MA; Montilla-Garcia, A; Gonzalez-Cano, R; Bravo-Caparros, I; Ruiz-Cantero, MC; Grandson, FR; Cobos, EJ

Targeting immune-driven opioid analgesia by sigma-1 receptors: Opening the door to novel perspectives for the analgesic use of sigma-1 antagonists.

PHARMACOLOGICAL RESEARCH, 2018;

FI: 4,897; D1

Amata, E; Rescifina, A; Prezzavento, O; Sand, E; Dichiara, M; Pittala, V; Montilla-Garcia, A; Punzo, F; Merino, P; Cobos, EJ; Marrazzo, A

(+) - Methyl (1R, 2S) -2 - {[4- (4-Chlorophenyl) -4-hydroxypiperidin-1-yl] methyl} -1-phenylcyclopropanecarboxylate [(+) - MR200] Derivatives as Potent and Selective Sigma Receptor Ligands: Stereochemistry and Pharmacological Properties

JOURNAL OF MEDICINAL CHEMISTRY, 2018;

FI: 6,253; D1

Bautista-Aguilera, OM; Budni, J; Mine, F; Medeiros, EB; Deuther-Conrad, W; Train, JM; Moraleda, I; Iriepa, I; Lopez-Munoz, F; Marco-Contelles, J

Contilisant, a Tetratarget Small Molecule for Alzheimer's Disease Therapy Combining Cholinesterase, Monoamine Oxidase Inhibition, and H3R Antagonism with S1R Agonism Profile

JOURNAL OF MEDICINAL CHEMISTRY, 2018;

FI: 6,253; D1

Bergkemper, M; Kronenberg, E; Thum, S; Borgel, F; Daniliuc, C; Schepmann, D; Grandson, FR; Brust, P; Reinoso, RF; Alvarez, I; Wunsch, B.

Synthesis, Receptor Affinity, and Antiallodynic Activity of Spirocyclic sigma Receptor Ligands with Exocyclic Amino Moiety

JOURNAL OF MEDICINAL CHEMISTRY, 2018;

FI: 6,253; D1

Cobos, EJ; Nickerson, CA; Gao, FY; Chandran, V; Bravo-Caparros, I; Gonzalez-Cano, R; Riva, P; Andrews, NA; Latremoliere, A; Seehus, CR; Perazzoli, G; Grandson, FR; Joller, N; Painter, MW; Ma, C.H.E.; Omura, T.; Chesler, EJ; Geschwind, DH; Coppola, G; Rangachari, M; Woolf, CJ; Costigan, M.

Mechanistic Differences in Neuropathic Pain Modalities Revealed by Correlating Behavior with Global Expression Profiling

CELL REPORTS, 2018;

FI: 8,032; Q1

Montilla-Garcia, A; Tejada, MA; Perazzoli, G; Train, JM; Portillo-Salido, E; Fernandez-Segura, E; Canizares, FJ; Cobos, EJ

Grip strength in mice with joint inflammation: A rheumatology function test sensitive to pain and analgesia

NEUROPHARMACOLOGY, 2017;

FI: 5,012; D1

Tejada, MA; Montilla-Garcia, A; Cronin, SJ; Cikes, D; Sanchez-Fernandez, C; Gonzalez-Cano, R; Ruiz-Cantero, MC; Penninger, JM; Sailing, JM; Baeyens, JM; Cobos, EJ

Sigma-1 receptors control immune-driven peripheral opioid analgesia during inflammation in mice

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2017;

FI: 9,661; D1

Contreras-Caceres, R; Leiva, M; Ortiz, R; Diaz, A; Perazzoli, G; Casado-Rodriguez, M; Melguizo, C; Baeyens, JM; Lopez-Romero, JM; Meadows, J

Paclitaxel-loaded hollow-poly (4-vinylpyridine) nanoparticles enhance drug chemotherapeutic efficacy in lung and breast cancer cell lines

NANO RESEARCH, 2017;

FI: 7,354; D1

Gonzalez-Cano, R; Tejada, MA; Artacho-Cordon, A; Nieto, FR; Train, JM; Wood, JN; Cendan, CM

Effects of Tetrodotoxin in Mouse Models of Visceral Pain

MARINE DRUGS, 2017;

FI: 3,503; Q1

Bravo-Caparros, I; Grandson, FR

Roles for CD8 (+) T Cells and IL-10 in the Resolution of Paclitaxel-Induced Neuropathic Pain

JOURNAL OF NEUROSCIENCE, 2017;

FI: 5,988; Q1

Train, JM; Sanchez-Fernandez, C; Nieto, FR; Gonzalez-Cano, R; Yeste, S; Cobos, EJ; Baeyens, JM

Sigma-1 Receptor Agonism Promotes Mechanical Allodynia After Priming the Nociceptive System with Capsaicin

SCIENTIFIC REPORTS, 2016;

FI: 5,228; Q1

Morata-Tarifa, C; Jimenez, G; Garcia, MA; Train, JM; Grinan-Lison, C; Aguilera, M; Picon-Ruiz, M; Marchal, JA

Low adherent cancer cell subpopulations are enriched in tumorigenic and metastatic epithelial-to-mesenchymal transition-induced cancer stem-like cells

SCIENTIFIC REPORTS, 2016;

FI: 5,228; Q1

Masocha, W; Gonzalez, LG; Agile, A

Distinguishing subgroups among mu-opioid receptor agonists using Na +, K + -ATPase as an effector mechanism

EUROPEAN JOURNAL OF PHARMACOLOGY, 2016;

FI: 2,73; Q2

Campos, D; Hernandez-Torres, JJ; Agil, A; Cumin, M; Lopez, JC; Macias, V; Campoy, C

Analysis of food advertising to children on Spanish television: probing exposure to television marketing

ARCHIVES OF MEDICAL SCIENCE, 2016;

FI: 1,812; Q2

Berglund, S.K.; Garcia-Valdes, L; Torres-Espinola, FJ; Segura, M.T.; Martinez-Zaldivar, C; Aguilar, MJ; Agile, A; Lorente, J.A.; Florid, J; Padilla, C; Altmae, S; Mark, A; Lopez-Sabater, MC; Campoy, C.

Maternal, fetal and perinatal alterations associated with obesity, overweight and gestational diabetes: an observational cohort study (PREOBE)

BMC PUBLIC HEALTH, 2016;

FI: 2,209; Q2

del Pozo, E; Arana-Asensio, E; Garcia-Lopez, P.

ACUTE CONFUSIONAL SYNDROME INDUCED BY MOXIFLOXACIN IN AN ELDERLY MAN

JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, 2015;

FI: 4,572; D1

Agile, A; El-Hammadi, M; Jimenez-Aranda, A; Tassi, M; Abdo, W; Fernandez-Vazquez, G; Reiter, R.J.

Melatonin reduces hepatic mitochondrial dysfunction in diabetic obese rats

JOURNAL OF PINEAL RESEARCH, 2015;

FI: 9,6; D1

Elmahallawy, EK; Luque, JO; Aloweidi, AS; Gutierrez-Fernandez, J; Sampedro-Martinez, A; Rodriguez-Granger, J; Kaki, A; Agile, A

Potential Relevance of Melatonin Against Some Infectious Agents: A Review and Assessment of Recent Research

CURRENT MEDICINAL CHEMISTRY, 2015;

FI: 3,853; D1

Roman, S; Agile, A; Peran, M; Alvaro-Galue, E; Ruiz-Ojeda, FJ; Fernandez-Vazquez, G; Marchal, J.A.

Brown adipose tissue and novel therapeutic approaches to treat metabolic disorders

TRANSLATIONAL RESEARCH, 2015;

FI: 5,03; D1

Luna-Sanchez, M; Diaz-Casado, E; Barca, E; Tejada, MA; Montilla-Garcia, A; Cobos, EJ; Scales, G; Acuna-Castroviejo, D; Quinzii, CM; Lopez, L.C.

The clinical heterogeneity of coenzyme Q (10) deficiency results from genotypic differences in the Coq9 gene

EMBO MOLECULAR MEDICINE, 2015;

FI: 8,665; D1

Role of the Sigma-1 receptor in the treatment of endometriosis-associated pain

Funder: CARLOS III HEALTH INSTITUTE - FEDER

File number: PI24 / 01755

Execution time: 01/01/2025 - 31/12/2027

IP: MIGUEL ANGEL TEJADA GIRALDEZ

A new multimodal approach for the treatment of postoperative pain

Funder: STATE RESEARCH AGENCY

File number: PID2023-150747OB-I00

Execution time: 01/09/2024 - 31/12/2028

PI: ENRIQUE JOSE COBOS DEL MORAL

EVALUATION OF THERAPEUTIC POTENTIAL OF SIGMA-1 RECEPTORS IN ENDOMETRIOSIS USING COMPUTERIZED BEHAVIORAL MEASUREMENTS

Funder: UNIVERSITY OF GRANADA

File number: C-CTS-226-UGR23

Execution time: 01/01/2024 - 31/12/2026

IP: MIGUEL ANGEL TEJADA GIRALDEZ

BEHAVIOURAL CONSEQUENCES OF EARLY ALCOHOL EXPOSURE: INFLUENCE OF FOLIC ACID AND SELENIUM SUPPLEMENTATION TO RESTORE OXIDATIVE BALANCE

Funder: UNIVERSITY OF GRANADA

File number: C-CTS-307-UGR23

Execution time: 01/01/2024 - 31/12/2026

PI: CRUZ MIGUEL CENDAN MARTINEZ

Molecular mechanisms of cytoplasmic and organellar calcium modulation and Ca2+-dependent pathways in skeletal muscle in response to melatonin in vivo and in vitro (ZDF rats and human myoblast

Funder: STATE RESEARCH AGENCY

File number: PID2021-125900OB-I00

Execution time: 01/09/2022 - 31/08/2025

IP: AHMAD AGIL ABDALLA

Inhibition of the sigma-1 (σ1) receptor and the soluble epoxide hydrolase enzyme: a new strategy for the treatment of pain in rheumatoid arthritis

Funder: STATE RESEARCH AGENCY

File number: PID2021-123058NA-I00

Execution time: 01/09/2022 - 31/08/2025

PI: FRANCISCO RAFAEL NIETO LOPEZ

Searching for new measures of pain in animals to refine the development of analgesics (MOUSEdata)

Funder: UNIVERSITY OF GRANADA

File number: 63

Execution time: 01/01/2023 - 31/12/2023

IP: RAFAEL GONZALEZ CANO

Sigma-1 receptors; Endogenous opioid analgesia and neuroinflammation in rheumatoid arthritis

Funder: UNIVERSITY OF GRANADA

File number: B-CTS-642-UGR20

Execution time: 01/07/2021 - 30/06/2023

PI: FRANCISCO RAFAEL NIETO LOPEZ

Multimodal analgesia in rheumatoid arthritis: sigma-1 receptor inhibition to increase the therapeutic range of NSAIDs

Funder: COUNCIL OF ECONOMIC TRANSFORMATION, INDUSTRY, KNOWLEDGE AND UNIVERSITIES

File number: PY20_00132

Execution time: 04/10/2021 - 30/06/2023

PI: ENRIQUE JOSE COBOS DEL MORAL

Modulation of mitochondrial dynamics and endoplasmic reticulum stress in brown and renal adipose tissue in response to the anti-obesity effect of melatonin in obese and diabetic rats

Funder: UNIVERSITY OF GRANADA

File number: B-CTS-102-UGR20

Execution time: 01/06/2021 - 31/05/2023

IP: AHMAD AGIL ABDALLA

Immunotherapy and inhibition of the sigma-1 (σ1) receptor as a therapeutic strategy for pain relief in rheumatoid arthritis

Funder: PUBLIC FOUNDATION FOR BIOSANITARY RESEARCH OF ORIENTAL ANDALUCIA ALEJANDRO OTERO (FIBAO)

File number: INTRAIBS-2020-09

Execution time: 01/01/2021 - 31/12/2021

PI: FRANCISCO RAFAEL NIETO LOPEZ

Inhibition of the sigma-1 receptor: a new strategy for the treatment of postoperative pain

Funder: STATE RESEARCH AGENCY

File number: PID2019-108691RB-I00

Execution time: 01/06/2020 - 30/05/2024

PI: ENRIQUE JOSE COBOS DEL MORAL

Neurobiological and behavioral determinants of binge-type alcohol consumption in adolescent female and male rats: role of sigma-1 receptors and their potential use as pharmacological treatment

Funder: MINISTRY OF HEALTH

File number: PND-2020-049

Execution time: 01/01/2021 - 31/12/2023

PI: CRUZ MIGUEL CENDAN MARTINEZ

Evaluation of the Analgesic Efficacy of a New Transcutaneous Electromagnetic System in Pathologies Associated with Peripheral Neuropathic Pain

Funder: COUNCIL OF HEALTH

File number: PIN-0505-2016

Execution time: 01/01/2017 - 31/12/2018

PI: RAFAEL GALVEZ MATEOS

Prialt® observatory in clinical practice (OP2C).

Funder: CLINACT

Test type: OBSERVATIONAL STUDY WITH MEDICINES

Execution time: 15/03/2024 - 30/12/2025

PI: RAFAEL GALVEZ MATEOS

Phase III, randomized, double-blind, placebo-comparative study to evaluate the efficacy and safety of a single intra-articular injection of RTX-GRT7039 in adult patients with pain derived from gonarthrosis.

Financier: GRÜNENTHAL GMBH

Type of test: CLINICAL TRIAL WITH DRUGS

Execution time: 23/11/2022 - 30/09/2024

PI: RAFAEL GALVEZ MATEOS

Randomized, double-blind, placebo-controlled, parallel-group study to evaluate the efficacy and safety of BIIB074 in subjects with lumbosacral radiculopathy neuropathic pain

Funder: CONVERGENCE PHARMACEUTICALS LIMITED

Type of test: COMMERCIAL CLINICAL TRIAL

Execution time: 20/04/2017 - 30/05/2018

PI: RAFAEL GALVEZ MATEOS

An Uncontrolled, Open-Label Extension Study to Evaluate the Long-Term Safety, Tolerability, and Maintenance of Effect of BIIB074 in Subjects With Neuropathic Pain From Lumbosacral Radiculopathy

Funder: BIOGEN IDEC LIMITED

Type of test: COMMERCIAL CLINICAL TRIAL

Execution time: 08/11/2017 - 30/04/2019

PI: RAFAEL GALVEZ MATEOS

Double-blind, placebo-controlled, randomized, dose-finding trial to determine the safety and efficacy of three dose levels of EMA401 in reducing the 24-hour mean pain intensity score in patients with postherpetic neuralgia (EMPHENE)

Funder: NOVARTIS FARMACEUTICA, SA

Type of test: COMMERCIAL CLINICAL TRIAL

Execution time: 21/07/2017 - 30/09/2019

PI: RAFAEL GALVEZ MATEOS