MP08-Biomarkers and Renal Inflammation

Information
Members
Publications
Projects
Clinical trials

The group's general line of research is the study of the physiology and pathophysiology of arterial hypertension, renal dysfunction and thyroid dysfunction. In addition, it aims to search for new biomarkers of kidney injury and fibrosis.

Research lines

Study of the physiology and pathophysiology of arterial hypertension, renal dysfunction and thyroid dysfunction.

Research networks

RICORS2040 (KIDNEY DISEASE) Inflammation and Immunopathology of Organs and Systems.

Keywords

Hypertension, Endothelial Dysfunction, Renal Dysfunction, Thyroid Dysfunction, Biomarkers.

Maria Jose Espigares Huete

ORCID

Maria Jose Torres Sanchez

ORCID

ALMUDENA PEREZ IVORY

Laura Fuentes Sanchez

MARIA DEL CARMEN RUIZ SOURCES

JOSE FELIX VARGAS PALOMARES

ORCID

J.C. de Paula; P.G. Olmedo; T. G. Gomez-Moracho; M. Buendia-Abad; M. Higes; R. Martin-Hernandez; A. Osuna; L.M. de Pablos

Promastigote EPS secretion and haptomonad biofilm formation as evolutionary adaptations of trypanosomatid parasites for colonizing honeybee hosts

NPJ BIOFILMS AND MICROBIOMES, 2024;

FI: 7,8; D1

Fuentes, M.V.; Gomez-Samblas, M.; Richter, O.; S.; Bueno-Marí, R.; Osuna, A.; Galán-Puchades, M.T.

Local terrestrial snails as natural intermediate hosts of the zoonotic parasite Angiostrongylus cantonensis in the new European endemic area of Valencia, Spain

ZOONOSES AND PUBLIC HEALTH, 2024;

FI: 2,4; Q1

Girl, NR; Pereira, E; Manzano, F; Quintana, MMJ; Osuna, A; Fuentes, MCR; Wangensteen, R.

Aminopeptidase Enzymes as Early Biomarkers of Cardiac Surgery-Associated Acute Kidney Injury and Long-Term Events

BIOMOLECULES, 2024;

FI: 4,8; Q1

Fernández-Moya, A; Oviedo, B; Liempi, A; Guerrero-Muñoz, J; Rivas, C; Arregui, R; Araneda, S; Cornet-Gomez, A; Maya, JD; Müller, M; Osuna, A; Castillo, C; Kemmerling, U

Trypanosoma cruzi-derived exovesicles contribute to parasite infection, tissue damage, and apoptotic cell death during ex vivo infection of human placental explants

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, 2024;

FI: 4,6; Q1

Lozano, N; Prescilla-Ledezma, A; Calabuig, E; Trelis, M; Maple, JMS; Hontangas, J.L.L.; de Pablos, LM; Gomez-Samblas, M; Osuna, A

Circulating extracellular vesicles in sera of chronic patients as a method for determining active parasitism in Chagas disease

PLOS NEGLECTED TROPICAL DISEASES, 2024;

FI: 3,4; Q1

Ruiz-Fuentes, MC; Caba-Molina, M; Polo-Moyano, A; Palomares-Bayo, M; De Gracia-Guindo, C

A 78-Year-Old Man with Chronic Kidney Disease and Monoclonal Gammopathy Who Developed Post-Transplant C3 Glomerulopathy-Recurrence or De Novo? A Case Report and Literature Review

AMERICAN JOURNAL OF CASE REPORTS, 2023;

Porrini, E; Pérez, NM; Díaz, JM; Lauzurrica, R; Rodríguez, JO; Torres, IS; Moreso, F; Garrit, JMC; Ruiz, RB; Vilaró, MI; Lima, MXM; Ramchand, S.K.; Ruiz, JC; de los Rios, FG; Alvarez, CR; Guindo, MDD; Macías, M; Vela, DB; Osuna, A; Bayés-Genís, B; Sánchez,

Post-transplant diabetes mellitus and renal cell cancer after renal transplantation

NEPHROLOGY DIALYSIS TRANSPLANTATION, 2023;

FI: 7,186; Q1

Villanego, F; Vigara, LA; Lopez, V; de Gracia, MD; Rodriguez-Benot, A; Bernal, G; Castro, P; Mazuecos, A

Changes over time in the causes of death with a functioning graft in kidney transplantation recipients

NEPHROLOGY, 2023;

FI: 2,6; Q3

Mazuecos, A; Villanego, F; Zarraga, S; Lopez, V; Oppenheimer, F; Llinas-Mallol, L; Hernandez, AM; Rivas, A; Ruiz-Fuentes, MC; Toapanta, NG; Jimenez, C; Hair, S; Beneyto, I; Aladren, MJ; Rodriguez-Benot, A; Canal, C; Molina, M; Perez-Flores, I; Saura, IM; Gavela, E; Franco, A; Lorenzo, I; Galeano, C; Tabernero, G; Perez-Tamajon, L; Martin-Moreno, PL; Fernandez-Giron, F; Siverio, O; Labrador, PJ; From Above, G; Simal, F; Cruzado, L; Moina, I; Mayor, G; Sanchez-Alvarez, E; Pascual, J; Crespo, M

Breakthrough Infections Following mRNA SARS-CoV-2 Vaccination in Kidney Transplant Recipients

TRANSPLANTATION, 2022;

FI: 5,385; Q1

Villanego, F; Mazuecos, A; Cubillo, B; Merino, MJ; Poveda, I; Saura, IM; Secured, O; Cruzado, L; Eady, M; Zarraga, S; Aladren, MJ; Hair, S; Lopez, V; Gonzalez, E; Lorenzo, I; Espi-Reig, J; Fernandez, C; Osma, J; Ruiz-Fuentes, MC; Toapanta, N; Franco, A; Burballa, CC; Munoz, MA; Crespo, M; Pascual, J.

Treatment with sotrovimab for SARS-CoV-2 infection in a cohort of high-risk kidney transplant recipients

CLINICAL KIDNEY JOURNAL, 2022;

FI: 5,86; Q1

Rivera, CF; Rodriguez, MC; Poveda, JL; Pascual, J; Crespo, M; Gomez, G; Pelegrin, SC; Paul, J; Lauzurica, R; Mir, MP; Moreso, F; Perello, M; Andres, A; Gonzalez, E; Fernandez, A; Mendiluce, A; Carbajo, BF; Fructuoso, AS; Calvo, N; Suarez, A; White, GB; Osuna, A; Ruiz-Fuentes, MC; Melilli, E; Perez, NM; Ramos, A; Fernandez, B; Lopez, V; Hernandez, D.

Bioavailability of once-daily tacrolimus formulations used in clinical practice in the management of De Novo kidney transplant recipients: the better study

CLINICAL TRANSPLANTATION, 2022;

FI: 3,456; Q2

Wangensteen, R; Gomez-Guzman, M; Banegas, I; Rodriguez-Gomez, I; Jimenez, R; Duarte, J; Garcia-Estan, J; Vargas, F.

Vasoconstrictor and Pressor Effects of Des-Aspartate-Angiotensin I in Rat

BIOMEDICINE, 2022;

FI: 4,757; Q2

Sacristan, PG; Garcia, EC; Perez, EBP; Ivory, AP; Sanchez, MJT; Moratalla, JMO; Guindo, CD; Fuentes, MCR; Ortega, A.O.

Risk of Severe Coronavirus Disease 2019 Infection in Kidney Transplant Recipients

TRANSPLANTATION PROCEEDINGS, 2022;

FI: 1,014; Q4

Villanego, F; Mazuecos, A; Perez-Flores, IM; Moreso, F.; Andrew, A; Jimenez-Martin, C; Molina, M.; Channel, C; Sanchez-Camara, LA; Zarraga, S; Ruiz-Fuentes, MD; Aladren, M.J.; Melilli, E; Lopez, V; Sanchez-Alvarez, E; Crespo, M; Pascual, J.

Predictors of severe COVID-19 in kidney transplant recipients in the different epidemic waves: Analysis of the Spanish Registry

AMERICAN JOURNAL OF TRANSPLANTATION, 2021;

FI: 8,086; D1

Buxeda, A; Arias-Cabrales, C; Perez-Saez, MJ; Chub, J; Pelegrin, SC; Melilli, E; Aladren, M.J.; Galeano, C; Lawrence, I; Mazuecos, A; Saura, I.M.; Frank, A; Ruiz-Fuentes, MD; Sanchez-Camara, LA; Siverio, O; Martin, ML; Gonzalez-Garcia, E; Lopez, V; Martin Mo

Use and Safety of Remdesivir in Kidney Transplant Recipients With COVID-19

KIDNEY INTERNATIONAL REPORTS, 2021;

FI: 4,164; Q1

Montoro-Molina, S; Quesada, A; O'Valle, F; Morales, N.M.; deGrace, M.D.; Rodriguez-Gomez, I; Osuna, A; Wangensteen, R; Vargas, F.

The Long-Term Study of Urinary Biomarkers of Renal Injury in Spontaneously Hypertensive Rats

KIDNEY & BLOOD PRESSURE RESEARCH, 2021;

FI: 2,687; Q3

Pascual, J; Melilli, E; Jimenez-Martin, C; Gonzalez-Monte, E; Zarraga, S; Gutierrez-Dalmau, A; Lopez-Jimenez, V; Play, J; Munoz-Cepeda, M; Lorenzo, I; Facundo, C; Ruiz-Fuentes, MD; Mazuecos, A; Sanchez-Alvarez, E; Crespo, M

COVID-19-related Mortality During the First 60 Days After Kidney Transplantation

EUROPEAN UROLOGY, 2020;

FI: 18,728; D1

Crespo, M; Zarraga, S; Alonso, A; Beneyto, I; Cut, CD; Rodriguez, AMF; Franco, A; Hernandez, D; Gonzalez-Roncero, FM; Martin, CJ; Jimeno, L; Valdemoros, LRL; Llorente, S; Mazuecos, A; Osuna, A; Ramos, JP; Benot, AR; San Millan, JCR; Fructuoso, AS; Tower

Monitoring of Donor-specific Anti-HLA Antibodies and Management of Immunosuppression in Kidney Transplant Recipients: An Evidence-based Expert Paper

TRANSPLANTATION, 2020;

FI: 4,546; D1

Macias-Ruiz, R; Jimenez-Jaimez, J; Alvarez-Lopez, M; Molina-Lerma, M; Sanchez-Millan, P; Wangensteen, R; Quesada, A; Osuna-Ortega, A; Tercedor-Sanchez, L.

Effect of pulmonary vein catheter ablation on kidney function in patients with atrial fibrillation. A prospective cohort study

SPANISH JOURNAL OF CARDIOLOGY, 2020;

FI: 4,642; Q1

Garcia, E.H.; Sources, RCM; Guindo, MCG; Gila, JDLG; Sources, N.R.; Ortega, A.O.

Development of Ureteral Stenosis / Obstruction in Kidney Transplant

TRANSPLANTATION PROCEEDINGS, 2020;

FI: 0,784; Q4

Lara, EP; Garcia, E. H.; Sources, MDR; Molina, M.C.; Guindo, MDD; Ortega, A.O.

Plasma Cell-Rich Acute Rejection in Renal Transplantation: A Case Report

TRANSPLANTATION PROCEEDINGS, 2020;

FI: 0,784; Q4

Gonzalez-Corvillo, C; Beneyto, I; Sanchez-Fructuoso, A; Perello, M; Alonso, A; Mazuecos, A; Jimenez, C; Zarraga, S; Paul, J; Lauzurica, R; Hernandez, D; Guirado, L; Franco, A; Ruiz, JC; Llorente, S; Crespo, M; Rodriguez-Benot, A; Guindo, MDD; Diaz-Corte, C; Gentle, MA

Direct-acting Antivirals for the Treatment of Kidney Transplant Patients With Chronic Hepatitis C Virus Infection in Spain: A Long-term Prospective Observational Study

TRANSPLANTATION DIRECT, 2019;

Porrini, E; Diaz, JM; Moreso, F; Lauzurrica, R; Ibernon, M; Towers, IS; Ruiz, R.B.; Rodriguez, AER; Mallen, P.D.; Bayes-Genis, B; Gainza, FJ; Osorio, JM; Osuna, A; Dominguez, R; Ruiz, JC; Sosa, AJ; Rinne, AG; Miranda, D.M.; Macias, M; Torres, A.

Prediabetes is a risk factor for cardiovascular disease following renal transplantation.

KIDNEY INTERNATIONAL, 2019;

FI: 8,306; D1

Vazquez, A; Sanchez-Rodriguez, E; Vargas, F; Montoro-Molina, S; Romero, M; Mirror-Calvo, JA; Vilchez, P; Jaramillo, S; Olmo-Garcia, L; Carrasco-Pancorbo, A; de la Torre, R; Fito, M; Covas, MI; from Victoria, EM; Mesa, MD

Cardioprotective Effect of a Virgin Olive Oil Enriched with Bioactive Compounds in Spontaneously Hypertensive Rats

NUTRIENTS, 2019;

FI: 4,171; Q1

Gila, JDLG; Guindo, MDD; Navarro-Mari, JM; Gutierrez-Fernandez, J.

Corynebacterium jeikeium urinary tract infection and good clinical response with nitrofurantoin treatment

SPANISH MAGAZINE OF CHEMOTHERAPY, 2019;

FI: 0,76; Q4

Cruz-Bustos, T; Ibarrola-Vannucci, AK; Diaz-Lozano, I; Ramirez, JL; Osuna, A.

Characterization and functionality of two members of the SPFH protein superfamily, prohibitin 1 and 2 in Leishmania major

PARASITES & VECTORS, 2018;

FI: 3,163; D1

Moreso, F; Crespo, M; Ruiz, JC; Torres, A; Gutierrez-Dalmau, A; Osuna, A; Perello, M; Pascual, J; Towers, I.B.; Redondo-Pachon, D; Rodrigo, E; Lopez-Hoyos, M; Seron, D.

Treatment of chronic antibody mediated rejection with intravenous immunoglobulins and rituximab: A multicenter, prospective, randomized, double-blind clinical trial.

AMERICAN JOURNAL OF TRANSPLANTATION, 2018;

FI: 6,493; D1

Gomez-Samblas, M; Bernal, D; Bolado-Ortiz, A; Vilchez, S; Bolas-Fernandez, F; Hawthorn, AM; Trelis, M; Osuna, A.

Intraperitoneal administration of the anti-IL-23 antibody prevents the establishment of intestinal nematodes in mice

SCIENTIFIC REPORTS, 2018;

FI: 4,122; Q1

Toral, M; Jimenez, R; Montoro-Molina, S; Romero, M; Wangensteen, R; Duarte, J; Vargas, F.

Thyroid hormones stimulate L-arginine transport in human endothelial cells

JOURNAL OF ENDOCRINOLOGY, 2018;

FI: 4,012; Q1

Bull, LMD; Moreira, L.R.; Osuna, A.

Extracellular Vesicles in Chagas Disease: A New Passenger for an Old Disease

FRONTIERS IN MICROBIOLOGY, 2018;

FI: 4,019; Q1

Quesada, A; Segarra, AB; Montoro-Molina, S; de Gracia, MD; Osuna, A; O'Valle, F; Gomez-Guzman, M; Vargas, F; Wangensteen, R

Glutamyl aminopeptidase in microvesicular and exosomal fractions of urine is related with renal dysfunction in cisplatin-treated rats.

PLOSONE, 2017;

FI: 2,806; Q1

Porrini, EL; Diaz, JM; Moreso, F; Mallen, PID; Towers, IS; Ibernon, M; Bayes-Genis, B; Benitez-Ruiz, R; Lampreabe, I; Lauzurrica, R; Osorio, JM; Osuna, A; Dominguez-Rollan, R; Ruiz, JC; Jimenez-Sosa, A; Gonzalez-Rinne, A; Marrero-Miranda, D; Macia, M; Garcia, J; Torres, A.