MP07-Bases Physiopathology and Medical Therapeutics

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Members
Publications
Projects
Clinical trials

Research group dedicated to deepening the knowledge of systemic autoimmune diseases from the epidemiological, clinical, genetic and basic immunology points of view. In addition, it works on the study of risk factors associated with the development of steroid osteoporosis, as well as its prevention and treatment.

Research lines

Nutrition and Systemic Autoimmune Diseases
Genetics of Systemic Autoimmune Diseases
corticosteroid osteoporosis
Epidemiology of Systemic Autoimmune Diseases
Clinical aspects and complications of autoimmune diseases

Keywords

Autoimmune Diseases, Lupus, Scleroderma, Systemic Vasculitis, Uveitis, Osteoporosis and Glucocorticoids.

SARA DEL OLM ROMERO

MARIA DEL ROCIO GIL GUTIERREZ

ORCID

MARTA GARCIA MORALES

JAVIER DE LA HERA FERNANDEZ

ORCID

MARIALBERT ACOSTA HERRERA

ORCID

ELIO GABRIEL CARMONA RUBIO

JOSE LUIS CALLEJAS RUBIO

Diaz-Villamarin, X; Fernandez-Varon, E; Romero, MCR; Callejas-Rubio, JL; Cabeza-Barrera, J; Rodriguez-Nogales, A; Galvez, J; Moron, R

Azathioprine dose tailoring based on pharmacogenetic information: Insights from clinical implementation

BIOMEDICINE & PHARMACOTHERAPY, 2023;

FI: 7,5; Q1

Rodriguez-Martin, I; Villanueva-Martin, G; Guillen-Del-Castillo, A; Ortego-Centeno, N; Callejas, JL; Simeon-Aznar, CP; Martin, J; Acosta-Herrera, M

Contribution of Telomere Length to Systemic Sclerosis Onset: A Mendelian Randomization Study

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023;

FI: 5,6; Q1

Casas-Barragan, A; Garcia-Rios, MC; Rus, A; Tapia-Haro, RM; Correa-Rodriguez, M; Aguilar-Ferrándiz, ME

Associations between serum VEGF and CGRP levels with the peripheral vascular blood flow of the skin of the hands in women with Fibromyalgia

JOURNAL OF THERMAL BIOLOGY, 2023;

FI: 2,7; Q2

Rus, A; Lopez-Sanchez, JA; Garcia-Rios, MC; Tapia-Haro, RM; Casas-Barragan, A; Correa-Rodriguez, M; Aguilar-Ferrándiz, ME

Calcitonin Gene-Related Peptide, Vascular Endothelial Growth Factor, and Clinical Manifestations in Women With Fibromyalgia

NURSING RESEARCH, 2023;

FI: 2,5; Q2

Correa-Rodriguez, M; Rueda-Medina, B; Callejas-Rubio, JL; Rios-Fernandez, R; Gil-Gutierrez, R; Ortego-Centeno, N

Adherence to antimalarials and glucocorticoids treatment and its association with self-reported disease activity in systemic lupus erythematosus patients

LUPUS, 2023;

FI: 2,6; Q3

Fernandez-Aparicio, A; Correa-Rodriguez, M; Castellano, JM; Schmidt-RioValle, J; Perona, JS; Gonzalez-Jimenez, E

Potential Molecular Targets of Oleanolic Acid in Insulin Resistance and Underlying Oxidative Stress: A Systematic Review

ANTIOXIDANTS, 2022;

FI: 7,675; D1

Carbonell, C; Marcos, M; Guillen-Del-Castillo, A; Rubio-Rivas, M; Argibay, A; Marin-Ballve, A; Rodriguez-Pinto, I; Balda-Masmiquel, M; Callejas-Moraga, E; Colunga, D; Saez-Comet, L; Gonzalez-Echavarri, C; Ortego-Centeno, N; Mari-Alfonso, B; Vargas-Hitos, JA; Todoli-Parra, JA; Trapiella, L; Herranz-Marin, MT; Freire, M; Castro-Salomo, A; Perales-Fraile, I; Madronero-Vuelta, AB; Sanchez-Garcia, ME; Ruiz-Munoz, M; Gonzalez-Garcia, A; Sanchez-Redondo, J; De-la-Red-Bellvis, G; Fernandez-Luque, A; Muela-Molinero, A; Lledo, GM; Tolosa-Vilella, C; Fonollosa-Pla, V; Chamorro, AJ; Simeon-Aznar, CP

Standardized incidence ratios and risk factors for cancer in patients with systemic sclerosis: Data from the Spanish Scleroderma Registry (RESCLE)

AUTOIMMUNITY REVIEWS, 2022;

FI: 17,39; D1

Ramirez-Velez, R; Garcia-Hermoso, A; Correa-Rodriguez, M; Left, M

Defining values for controlled attenuation parameter and liver stiffness in youth without liver disease

PEDIATRIC RESEARCH, 2022;

FI: 3,953; Q1

Ramirez-Velez, R; Garcia-Hermoso, A; Correa-Rodriguez, M; Fernandez-Irigoyen, J; Palomino-Echeverria, S; Santamaria, E; Correa-Bautista, JE; Gonzalez-Ruiz, K; Left, M

Effects of Different Doses of Exercise on Inflammation Markers Among Adolescents With Overweight/Obesity: HEPAFIT Study

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2022;

FI: 6,134; Q1

Gonzalez-Ruiz, K; Correa-Bautista, JE; Izquierdo, M; Garcia-Hermoso, A; Martinez-Vizcaino, V; Lobelo, F; Gonzalez-Jimenez, E; Schmidt-RioValle, J; Correa-Rodriguez, M; Fernandez-Irigoyen, J; Palomino-Echeverria, S; Santamaria, E; Ramirez-Velez, R

Exercise dose on hepatic fat and cardiovascular health in adolescents with excess of adiposity.

PEDIATRIC OBESITY, 2022;

FI: 3,91; Q1

Simon, Q; Grasseau, A; Boudigou, M; Le Pottier, L.; Bettachioli, E; Cornec, D; Rouviere, B; Jamin, C; Le Lann, L.; Borghi, MO; Aguilar-Quesada, R; Renaudineau, Y; Alarcon-Riquelme, ME; Pers, JO; Hillion, S.

A Proinflammatory Cytokine Network Profile in Th1/Type 1 Effector B Cells Delineates a Common Group of Patients in Four Systemic Autoimmune Diseases

ARTHRITIS & RHEUMATOLOGY, 2021;

FI: 10,995; D1

Rueda-Medina, B; Gomez-Urquiza, JL; Molina-Rivas, E; Tapia-Haro, R; Aguilar-Ferrandiz, ME; Correa-Rodriguez, M.

A Combination of Self-debriefing and Instructor-led Debriefing Improves Team Effectiveness in Health Science Students….

NURSE EDUCATOR, 2021;

FI: 2,082; Q2

Rueda-Medina, B; Gomez-Urquiza, JL; Molina-Rivas, E; Tapia-Haro, R; Aguilar-Ferrandiz, ME; Correa-Rodriguez, M.

A Combination of Self-debriefing and Instructor-led Debriefing Improves Team Effectiveness in Health Science Students

NURSE EDUCATOR, 2021;

FI: 2,082; Q2

Ramirez-Velez, R; Garcia-Hermoso, A; Correa-Rodriguez, M; Lobelo, F; González-Ruiz, K; left, M

Abdominal aortic calcification is associated with decline in handgrip strength in the US adult population >40 years of age.

NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES, 2021;

FI: 4,222; Q2

Ramirez-Velez, R; Garcia-Hermoso, A; Correa-Rodriguez, M; Lobelo, F; González-Ruiz, K; left, M

Abdominal aortic calcification is associated with decline in handgrip strength in the US adult population >40 years of age

NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES, 2021;

FI: 4,222; Q2

Gonzalez-Serna, D; Ochoa, E; Lopez-Isac, E; Julie, A; Degenhardt, F; Ortego-Centeno, N; Radstake, TRDJ; Franke, A; Marsal, S; Mayes, M.D.; Martin, J; Marquez, A.

A cross-disease meta-GWAS identifies four new susceptibility loci shared between systemic sclerosis and Crohn's disease

SCIENTIFIC REPORTS, 2020;

FI: 3,998; Q1

Atencio-Osorio, MA; Carrillo-Arango, HA; Correa-Rodriguez, M; Ochoa-Munoz, AF; Ramirez-Velez, R.

Adherence to the Mediterranean Diet in College Students: Evaluation of Psychometric Properties of the KIDMED Questionnaire

NUTRIENTS, 2020;

FI: 4,546; Q1

Rueda-Medina, B; Gomez-Urquiza, JL; Tapia-Haro, R; Casas-Barragan, A; Aguilar-Ferrandiz, ME; Correa-Rodriguez, M.

Assessing health science students' health literacy and its association with health behaviors

HEALTH & SOCIAL CARE IN THE COMMUNITY, 2020;

FI: 2,05; Q1

Ramirez-Velez, R; Perez-Sousa, MA; Cano-Gutierrez, CA; Left, M; Garcia-Hermoso, A; Correa-Rodriguez, M

Association Between Ideal Cardiovascular Health Score and Relative Handgrip Strength of Community-Dwelling Older Adults in Colombia

JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION, 2020;

FI: 4,367; Q1

Alvarez-Cienfuegos, A; Cantero-Nieto, L; Garcia-Gomez, JA; Sage, JM; Gonzalez-Gay, MA; Ortego-Centeno, N

Association between homocysteine levels and arterial stiffness in women with systemic sclerosis

CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, 2020;

FI: 3,319; Q2

Acosta-Herrera, M; Kerick, M; Gonzalez-Serna, D; Wijmenga, C; Franke, A; Gregersen, PK; Padyukov, L; Worthington, J; Vyse, TJ; Alarcon-Riquelme, ME; Mayes, MD; Martin, J; Miller, FW; Chen, W; O'Hanlon, TP; Cooper, RG; Vencovsky, J; Rider, LG; Danko, K; Wedderburn, LR; Lundberg, IE; Pachman, LM; Reed, AM; Ytterberg, SR; Selva-O'Callaghan, A; Radstake, TR; Isenberg, DA; Chinoy, H; Ollier, WER; Scheet, P; Peng, B; Lee, A; Lamb, JA; Amos, CI; Denton, C; Hilton-Jones, D; Plotz, PH; Varsani, H; Radstake, TRDJ; Gorlova, O; Wheel, B; Martin, JE; Alizadeh, BZ; Palomino-Morales, R; Coenen, MJ; Vonk, MC; Voskuyl, AE; Scheurwegh, AJ; Broen, JC; van Riel, PLCM; van 't Slot, R; Italiaander, A; Ophoff, RA; Riemekasten, G; Hunzelmann, N; Simeon, CP; Ortego-Centeno, N; Gonzalez-Gay, MA; Gonzalez-Escribano, MF; Airo, P; van Laar, J; Herrick, A; Hesselstrand, R; Smith, V; de Keyser, F; Houssiau, F; Chee, MM; Madhok, R; Shiels, P; Westhovens, R; Kreuter, A; Kiener, H; de Baere, E; Witte, T; Klareskog, L; Beretta, L; Scorza, R; Lie, BA; Hoffman-Vold, AM; Carreira, P; Varga, J; Hinchcliff, M; Lee, AT; Ying, J; Han, Y; Weng, SF; Wigley, FM; Hummers, L; Nelson, JL; Agarwal, SK; Assassi, S; Gourh, P; Tan, FK; Koeleman, BPC; Arnett, FC

Genome-wide meta-analysis reveals shared new loci in systemic seropositive rheumatic diseases.

ANNALS OF THE RHEUMATIC DISEASES, 2019;

FI: 14,299; D1

Atienza-Mateo, B; Martin-Varillas, JL; Calvo-Rio, V; Demetrio-Pablo, R; Beltran, E; Sanchez-Burson, J; Mesquida, M; Adam, A; Hernandez, MV; Hernandez-Garfella, M; Valls-Pascual, E; Martinez-Costa, L; Sellas-Fernandez, A; Lamb-Eat, M; Diaz-Llopis, M; Gallego, R; Garcia-Serrano, JL; Ortego-Centeno, N; Herreras, JM; Fonollosa, A; Garcia-Aparicio, AM; Maiz-Alonso, O; White, A; Torre-Salaberri, I; Fernandez-Espartero, C; Jovani, V; Peiteado, D; Duck, E; Cruz, J; Fernandez-Cid, C; Aurrecoechea, E; Garcia-Arias, M; Castaneda, S; Caracuel-Ruiz, MA; Montilla-Morales, CA; Atanes-Sandoval, A; Francisco, F; Insua, S; Gonzalez-Suarez, S; Sanchez-Andrade, A; Gamero, F; Ferrando, LFL; Romero-Bueno, F; Garcia-Gonzalez, AJ; Gonzalez, RA; Muro, EM; Carrasco-Cubero, C; Olive, A; Prior, A; Vazquez, J; Ruiz-Moreno, O; Jimenez-Zorzo, F; Manero, J; Fernandez, SM; Fernandez-Carballido, C; Rubio-Romero, E; Pages, FA; de Miera, FJTS; Martinez, MG; Diaz-Valle, D; Longo, FJL; Nolla, JM; Alvarez, ER; Martinez, MR; Gonzalez-Lopez, JJ; Rodriguez-Cundin, P; Hernandez, JL; Gonzalez-Gay, MA; White, R

Comparative Study of Infliximab Versus Adalimumab in Refractory Uveitis due to Behcet's Disease: National Multicenter Study of 177 Cases

ARTHRITIS & RHEUMATOLOGY, 2019;

FI: 9,002; D1

Cavagna, L; Trallero-Araguas, E; Meloni, F; Cavazzana, I; Rojas-Serrano, J; Feist, E; Zanframundo, G; Morandi, V; Meyer, A; da Silva, JAP; Costa, CJM; Molberg, O; Andersson, H; Codullo, V; Mosca, M; Barsotti, S; Neri, R; Scire, C; Govoni, M; Furini, F; Lopez-Longo, FJ; Martinez-Barrio, J; Schneider, U; Lorenz, HM; Doria, A; Ghirardello, A; Ortego-Centeno, N; Confalonieri, M; Tomietto, P; Pipitone, N; Cambron, APR; Canamero, MAB; Voll, RE; Wendel, S; Scarpato, S; Maurier, F; Limonta, M; Colombelli, P; Giannini, M; Geny, B; Arrigoni, E; Bravi, E; Migliorini, P; Mathieu, A; Piga, M; Drott, U; Delbrueck, C; Bauhammer, J; Cagnotto, G; Vancheri, C; Sambataro, G; From Langhe, E; Sainaghi, PP; Monti, C; Berzolari, FG; Romano, M; Bonella, F; Specker, C; Schwarting, A; White, IV; Selmi, C; Ceribelli, A; Nuno, L; Mera-Varela, A; Gomez, NP; Fusaro, E; Parisi, S; Sinigaglia, L; Del Papa, N; Benucci, M; Cimmino, MA; Riccieri, V; Conti, F; Sebastiani, GD; Iuliano, A; Emmi, G; Cammelli, D; Sebastiani, M; Manfredi, A; Bachiller-Corral, J; Giraldo, WAS; Paolazzi, G; Saketkoo, LA; Giorgi, R; Salaffi, F; Cifrian, J; Caporali, R; Locatelli, F; Marchioni, E; Pesci, A; Dei, GL; Pozzi, MR; Claudia, L; Distler, J; Knitza, J; Schett, G; Iannone, F; Fornaro, M; Franceschini, F; Quartuccio, L; Gerli, R; Bartoloni, E; Randone, SB; Zampogna, G; Perez, MIG; Mejia, M; Vicente, E; Triantafyllias, K; Lopez-Mejias, R; Matucci-Cerinic, M; Selva-O'Callaghan, A; Castaneda, S; Montecucco, C; Gonzalez-Gay, MA

Influence of Antisynthetase Antibodies Specificities on Antisynthetase Syndrome Clinical Spectrum Time Course

JOURNAL OF CLINICAL MEDICINE, 2019;

FI: 5,688; D1

Lopez-Isac, E; Acosta-Herrera, M; Kerick, M; Assassi, S; Satpathy, AT; Farm, J; Mumbach, MR; Beretta, L; Simeon, CP; Carreira, P; Ortego-Centeno, N; Castellvi, I; Bossini-Castillo, L; Carmona, FD; Orozco, G; Hunzelmann, N; Distler, JHW; Franke, A; Lunardi, C; Moroncini, G; Gabrielli, A; de Vries-Bouwstra, J; Wijmenga, C; Koeleman, BPC; Nordin, A; Padyukov, L; Hoffmann-Vold, AM; Lie, B; Rios, R; Callejas, JL; Vargas-Hitos, JA; Garcia-Portales, R; Camps, MT; Fernandez-Nebro, A; Gonzalez-Escribano, MF; Garcia-Hernandez, FJ; Castillo, MJ; Aguirre, MA; Gomez-Gracia, I; Fernandez-Gutierrez, B; Rodriguez-Rodriguez, L; de la Pena, PG; Vicente, E; Andreu, JL; de Castro, MF; Lopez-Longo, FJ; Martinez, L; Fonollosa, V; Guillen, A; Espinosa, G; Tolosa, C; Pros, A; Rodriguez-Carballeira, M; Narvaez, FJ; Rubio-Rivas, M; Ortiz-Santamaria, V; Madronero, AB; Gonzalez-Gay, MA; Diaz, B; Trapiella, L; Sousa, A; Egurbide, MV; Fanlo-Mateo, P; Saez-Comet, L; Diaz, F; Hernandez, V; Beltran, E; Roman-Ivorra, JA; Grau, E; Alegre-Sancho, JJ; Freire, M; Blanco-Garcia, FJ; Oreiro, N; Witte, T; Kreuter, A; Riemekasten, G; Airo, P; Lean, C; Voskuyl, AE; Vonk, MC; Hesselstrand, R; Proudman, S; Stevens, W; Nikpour, M; Zochling, J; Sahhar, J; Roddy, J; Nash, P; Tymms, K; Rischmueller, M; Lester, S; Vyse, T; Herrick, AL; Worthington, J; Denton, CP; Allanore, Y; Brown, MA; Radstake, TRDJ; Fonseca, C; Chang, HY; Mayes, MD; Martin, J

GWAS for systemic sclerosis identifies multiple risk loci and highlights fibrotic and vasculopathy pathways

NATURE COMMUNICATIONS, 2019;

FI: 11,878; D1

Mensa-Vilaro, A; Garcia-Morato, MB; de la Calle-Martin, O; Franco-Jarava, C; Martinez-Saavedra, MT; Gonzalez-Granado, LI; Gonzalez-Roca, E; Fuster, JL; Alsina, L; Mutchinick, OM; Balderrama-Rodriguez, A; Ramos, E; Modesto, C; Mesa-del-Castillo, P; Ortego-Centeno, N; Clemente, D; Souto, A; Palmou, N; Remesal, A; Leslie, KS; de la Fuente, EG; Gallego, LYB; Campistol, JM; Dhouib, NG; Bejaoui, M; Dutra, LA; Terreri, MT; Mosquera, C; Gonzalez, T; Canellas, J; de Morales, JMGR; Wouters, CH; Forest, MT; Cham, WT; Jimenez-Trevino, S; by Inocencio, J; Bloomfield, M; de Diego, RP; Martinez-Pomar, N; Rodriguez-Pena, R; Gonzalez-Santesteban, C; Soler-Palacin, P; Casals, F; Yague, J; Allende, LM; Rodriguez-Gallego, JC; Colobran, R; Martinez-Martinez, L; Lopez-Granados, E; Arostegui, JI

Unexpected relevant role of gene mosaicism in patients with primary immunodeficiency diseases.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2019;

FI: 14,11; D1

Marquez, A; Kerick, M; Zhernakova, A; Gutierrez-Achury, J; Chen, W.M.; Onengut-Gumuscu, S; Gonzalez-Alvaro, I; Rodriguez-Rodriguez, L; Rios-Fernandez, R; Gonzalez-Gay, MA; Mayes, M.D.; Raychaudhuri, S; Rich, SS; Wijmenga, C; Martin, J.

Meta-analysis of Immunochip data of four autoimmune diseases reveals novel single-disease and cross-phenotype associations.

GENOME MEDICINE, 2018;

FI: 8,898; D1

Martorana, D; Marquez, A; Carmona, F.D.; Bonatti, F; Adorni, A; Urban, M.L.; Maritati, F; Buttini, EA; Marvisi, C; Palmisano, A; Rossi, GM; Trivioli, G; Fenaroli, P; Manenti, L; Nicastro, M; Incerti, M; Gianfreda, D; Bani, S; Ferretti, S; Corradi, D; Alberici, F; Emma, G; Di Scala, G; Moroni, G; Percesepe, A; Scheel, PJ; Vermeer, E; van Bommel, E.F.; Martin, J; Vaglio, A.

A large-scale genetic analysis reveals an autoimmune origin of idiopathic retroperitoneal fibrosis.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2018;

FI: 13,258; D1

Martin-Varillas, JL; Calvo-Rio, V; Beltran, E; Sanchez-Burson, J; Mesquida, M; Adam, A; Hernandez, MV; Garfella, MH; Pascual, EV; Martinez-Costa, L; Sellas-Fernandez, A; Lamb-Eat, M; Diaz-Llopis, M; Gallego, R; Salom, D; Ortego, N; Garcia-Serrano, JL; Callejas-Rubio, JL; Herreras, JM; Garcia-Aparicio, A; Corn, O; White, A; Tower, I; Diaz-Valle, D; Duck, E; Aurrecoechea, E; Caracuel, MA; Gamero, F; Minguez, E; Carrasco-Cubero, C; Olive, A; Vazquez, J; Ruiz-Moreno, O; Manero, J; Munoz-Fernandez, S; Martinez, MG; Rubio-Romero, E; de Miera, FJTS; Longo, FJL; Nolla, JM; Revenga, M; Gonzalez-Vela, C; Loricera, J; Atienza-Mateo, B; Demetrio-Pablo, R; Hernandez, JL; Gonzalez-Gay, MA; White, R

Successful Optimization of Adalimumab Therapy in Refractory Uveitis Due to Behcet's Disease

OPHTHALMOLOGY, 2018;

FI: 7,479; D1

Soriano-Maldonado, A; Morillas-de-Laguno, P; Sage, JM; Gavilan-Carrera, B; Rosales-Castillo, A; Montalban-Mendez, C; Saez-Uran, LM; Callejas-Rubio, JL; Vargas-Hitos, JA

Effects of 12-week Aerobic Exercise on Arterial Stiffness, Inflammation, and Cardiorespiratory Fitness in Women with Systemic LUPUS Erythematosus: Non-Randomized Controlled Trial

JOURNAL OF CLINICAL MEDICINE, 2018;

FI: 5,583; D1

Gonzalez-Serna, D; Carmona, E.G.; Ortego-Centeno, N; Simeon, C.P.; Solans, R; Hernandez-Rodriguez, J; Toulouse, C; Castaneda, S; Narvaez, J; Martinez-Valle, F; Witte, T; Neumann, T; Holle, J; Beretta, L; Boyardi, L; Emma, G; Cimmino, MA; Vaglio, A; Herrick, AL; Denton, C.P.; Salvarani, C; Cid, M.C.; Morgan, A.W.; Fonseca, C; Gonzalez-Gay, MA; Martin, J; Marquez, A.

A TNFSF13B functional variant is not involved in systemic sclerosis and giant cell arteritis susceptibility

PLOSONE, 2018;

FI: 2,766; Q1

Trapiella-Martinez, L; Diaz-Lopez, JB; Caminal-Montero, L; Tolosa-Vilella, C; Castle, AGD; Colunga-Arguelles, D; Rubio-Rivas, M; Iniesta-Arandia, N; Castillo-Palma, MJ; Saez-Comet, L; Egurbide-Arberas, M.V.; Ortego-Centeno, N; Freire, M; Vargas-Hitos, JA; Rios-Blanco, JJ; Todoli-Parra, J.A.; Rodriguez-Carballeira, M; Marin-Ballve, A; Chamorro-Fernandez, AJ; Pla-Salas, X; Madronero-Vuelta, AB; Ruiz-Munoz, M; Fonollosa-Pla, V; Simeon-Aznar, CP

Very early and early systemic sclerosis in the Spanish scleroderma Registry (RESCLE) cohort

AUTOIMMUNITY REVIEWS, 2017;

FI: 8,961; D1

Bartoloni, E; Gonzalez-Gay, MA; Scire, C; Castaneda, S; Gerli, R; Lopez-Longo, FJ; Martinez-Barrio, J; Govoni, M; Furini, F; Pineapple, T; Iannone, F; Giannini, M; Nuno, L; Quartuccio, L; Ortego-Centeno, N; Student, A; Specker, C; Montecucco, C; Triantafyllias, K; Balduzzi, S; Sifuentes-Giraldo, WA; Paolazzi, G; Bravi, E; Schwarting, A; Pellerito, R; Russo, A; Selmi, C; Saketkoo, LA; Fusaro, E; Parisi, S; Pipitone, N; Franceschini, F; Cavazzana, I; Neri, R; Barsotti, S; Codullo, V; Cavagna, L.

Clinical follow-up predictors of disease pattern change in anti-Jo1 positive anti-synthetase syndrome: Results from a multicenter, international and retrospective study

AUTOIMMUNITY REVIEWS, 2017;

FI: 8,961; D1

Langefeld, CD; Ainsworth, HC; Graham, DSC; Kelly, JA; Comeau, ME; Marion, MC; Howard, TD; Ramos, PS; Croker, JA; Morris, DL; Sandling, JK; Almlof, JC; Acevedo-Vasquez, EM; Alarcon, GS; Babini, AM; Baca, V; Bengtsson, AA; Berbotto, GA; Bijl, M; Brown, EE; Brunner, HI; Cardiel, MH; Catoggio, L; Cervera, R; Cucho-Venegas, JM; Dahlqvist, SR; D'Alfonso, S; Silva, BM; Figueroa, ID; Doria, A; Edberg, JC; Endreffy, E; Esquivel-Valerio, JA; Fortin, PR; Freedman, BI; Frostegard, J; Garcia, MA; de la Torre, IG; Gilkeson, GS; Gladman, DD; Gunnarsson, I; Guthridge, JM; Huggins, JL; James, JA; Kallenberg, CGM; Kamen, DL; Karp, DR; Kaufman, KM; Kottyan, LC; Kovacs, L; Laustrup, H; Lauwerys, BR; Li, QZ; Maradiaga-Cecena, MA; Martin, J; McCune, JM; McWilliams, DR; Merrill, JT; Miranda, P; Moctezuma, JF; Nath, SK; Niewold, TB; Orozco, L; Ortego-Centeno, N; Petri, M; Pineau, CA; Pons-Estel, BA; Pope, J; Raj, P; Ramsey-Goldman, R; Reveille, JD; Russell, LP; Sage, JM; Aguilar-Salinas, CA; Scherbarth, HR; Scorza, R; Seldin, MF; Sjowall, C; Svenungsson, E; Thompson, SD; Toloza, SMA; Truedsson, L; Tusie-Luna, T; Vasconcelos, C; Vila, LM; Wallace, DJ; Weisman, MH; Wither, JE; Bhangale, T; Oksenberg, JR; Rioux, JD; Gregersen, PK; Syvanen, AC; Ronnblom, L; Criswell, LA; Jacob, CO; Sivils, KL; Tsao, BP; Schanberg, LE; Behrens, TW; Silverman, ED; Alarcon-Riquelme, ME; Kimberly, RP; Harley, JB; Wakeland, EK; Graham, RR; Gaffney, PM; Vyse, TJ

Transancestral mapping and genetic load in systemic lupus erythematosus

NATURE COMMUNICATIONS, 2017;

FI: 12,124; D1

Lopez-Isac, E; Bossini-Castillo, L; Palm, AB; Assassi, S; Mayes, M.D.; Simeon, C.P.; Ortego-Centeno, N; Vincent, E; Toulouse, C; Rubio-Rivas, M; Roman-Ivorra, J.A.; Beretta, L; Moroncini, G; Hunzelmann, N; Distler, JHW; Riemekasten, G; de Vries-Bouwstra, J; Voskuyl, A.E.; Radstake, TRDJ; Herrick, A; Denton, C.P.; Fonseca, C; Martin, J.

Analysis of ATP8B4 F436L Missense Variant in a Large Systemic Sclerosis Cohort

ARTHRITIS & RHEUMATOLOGY, 2017;

FI: 6,918; D1

Marquez, A; Vidal-Bralo, L; Rodriguez-Rodriguez, L; Gonzalez-Gay, MA; Balsa, A; Gonzalez-Alvaro, I; Carreira, P; Ortego-Centeno, N; Ayala-Gutierrez, MM; Garcia-Hernandez, FJ; Gonzalez-Escribano, MF; Sage, JM; Tolosa, C; Suarez, A; Gonzalez, A; Padyukov, L; Worthington, J; Vyse, T; Alarcon-Riquelme, ME; Martin, J

A combined large-scale meta-analysis identifies COG6 as a novel shared risk locus for rheumatoid arthritis and systemic lupus erythernatosus

ANNALS OF THE RHEUMATIC DISEASES, 2017;

FI: 12,811; D1

Lopez-Isac, E; Campillo-Davo, D; Bossini-Castillo, L; War, SG; Assassi, S; Simeon, CP; Carreira, P; Ortego-Centeno, N; de la Pena, PG; Beretta, L; Santaniello, A; Bellocchi, C; Lunardi, C; Moroncini, G; Gabrielli, A; Riemekasten, G; Witte, T; Hunzelmann, N; Kreuter, A; Distler, JHW; Voskuyl, AE; de Vries-Bouwstra, J; Herrick, A; Worthington, J; Denton, CP; Fonseca, C; Radstake, TRDJ; Mayes, MD; Martin, J

Influence of TYK2 on systemic sclerosis susceptibility: a new locus in the IL-12 pathway

ANNALS OF THE RHEUMATIC DISEASES, 2016;

FI: 12,384; D1

Demelo-Rodriguez, P; Ortego-Centeno, N; Callejas-Rubio, J.L.

groove sign

EUROPEAN JOURNAL OF INTERNAL MEDICINE, 2016;

FI: 2,591; Q1

Marquez, A; Martin, J; Carmona, F.D.

Emerging aspects of molecular biomarkers for diagnosis, prognosis and treatment response in rheumatoid arthritis.

EXPERT REVIEW OF MOLECULAR DIAGNOSTICS, 2016;

FI: 3,333; Q1

Lopez-Isac, E; Martin, J.E.; Assassi, S; Simeon, C.P.; Carrera, P; Ortego-Centeno, N; Freire, M; Beltran, E; Narvaez, J; Alegre-Sancho, JJ; Fernandez-Gutierrez, B; Raft, A; Ortiz, AM; Gonzalez-Gay, MA; Beretta, L; Santaniello, A; Bellocchi, C; Lunardi, C; Moroncini, G; Gabrielli, A; Witte, T; Hunzelmann, N; Distler, JHW; Riekemasten, G; van der Helm-Van Mil, AH; de Vries-Bouwstra, J; Magro-Czech, C; Voskuyl, A.E.; Vonk, M.C.; Molberg, O; Merriman, T; Hesselstrand, R; Nordin, A; Padyukov, L; Herrick, A; Eyre, S; Koeleman, BPC; Denton, C.P.; Fonseca, C; Radstake, TRDJ; Worthington, J; Mayes, M.D.; Martin, J.

IRF4 Newly Identified as a Common Susceptibility Locus for Systemic Sclerosis and Rheumatoid Arthritis in a Cross-Disease Meta-Analysis of Genome-Wide Association Studies

ARTHRITIS & RHEUMATOLOGY, 2016;

FI: 6,009; Q1

Ortiz-Fernandez, L; Carmona, FD; Montes-Cano, MA; Garcia-Lozano, JR; Conde-Jaldon, M; Ortego-Centeno, N; Castillo, MJ; Espinosa, G; Grana-Gil, G; Sanchez-Burson, J; Julia, MR; Solans, R; White, R; Barnosi-Marin, AC; de la Torre, RG; Fanlo, P; Rodriguez-Carballeira, M; Rodriguez-Rodriguez, L; Camps, T; Castaneda, S; Alegre-Sancho, JJ; Martin, J; Gonzalez-Escribano, MF

Genetic Analysis with the Immunochip Platform in Behcet's Disease. Identification of Residues Associated in the HLA Class I Region and New Susceptibility Loci

PLOSONE, 2016;

FI: 3,057; Q1

Cavagna, L; Nuno, L; Scire, CA; Govoni, M; Longo, FJL; Franceschini, F; Neri, R; Castaneda, S; Giraldo, WAS; Caporali, R; Iannone, F; Fusaro, E; Paolazzi, G; Pellerito, R; Schwarting, A; Saketkoo, LA; Ortego-Centeno, N; Quartuccio, L; Bartoloni, E; Specker, C; Murcia, TP; The Court, R; Furini, F; Foschi, V; Corral, JB; Airo, P; Cavazzana, I; Martinez-Barrio, J; Hinojosa, M; Giannini, M; Barsotti, S; Menke, J; Triantafyllias, K; Vitetta, R; Russo, A; Bajocchi, G; Bravi, E; Barausse, G; Bortolotti, R; Selmi, C; Parisi, S; Montecucco, C; Gonzalez-Gay, MA

Clinical Spectrum Time Course in Anti Jo-1 Positive Antisynthetase Syndrome Results From an International Retrospective Multicenter Study

MEDICINE, 2015;

FI: 5,723; D1

Oparina, NY; Delgado-Vega, AM; Martinez-Bueno, M; Magro-Checa, C; Fernandez, C; Castro, RO; Pons-Estel, BA; D'Alfonso, S; Sebastiani, GD; Witte, T; Lauwerys, BR; Endreffy, E; Kovacs, L; Escudero, A; Lopez-Pedrera, C; Vasconcelos, C; da Silva, BM; Frostegard, J; Truedsson, L; Martin, J; Stripe, E; Ortego-Centeno, N; Aguirre, MD; Garrido, ED; Palma, MJC; Alarcon-Riquelme, ME; Kozyrev, SV

PXK locus in systemic lupus erythematosus: fine mapping and functional analysis reveals novel susceptibility gene ABHD6

ANNALS OF THE RHEUMATIC DISEASES, 2015;

FI: 10,377; D1

Simeon-Aznar, C.P.; Fonollosa-Pla, V; Tolosa-Vilella, C; Espinosa-Garriga, G; Campillo-Grau, M; Ramos-Casals, M; Garcia-Hernandez, FJ; Castillo-Palma, MJ; Sanchez-Roman, J; Callejas-Rubio, JL; Ortego-Centeno, N; Egurbide-Arberas, M.V.; Trapiellla-Martinez, L; Caminal-Montero, L; Saez-Comet, L; Velilla-Marco, J; Camps-Garcia, MT; de Ramon-Garrido, E; Esteban-Marcos, EM; Pallares-Ferreres, L; Navarrete-Navarrete, N; Vargas-Hitos, JA; de la Torre, RG; Salvador-Cervello, G; Rios-Blanco, JJ; Vilardell-Tarres, M.

Registry of the Spanish Network for Systemic Sclerosis Survival, Prognostic Factors, and Causes of Death

MEDICINE, 2015;

FI: 5,723; D1

Nakagawa, K; Gonzalez-Roca, E; Souto, A; Kawai, T; Umebayashi, H.; Campistol, JM; Canellas, J; Takei, S; Kobayashi, N; Callejas-Rubio, JL; Ortego-Centeno, N; Ruiz-Ortiz, E; Rius, F; Anton, J; Iglesias, E; Jimenez-Trevino, S; Vargas, C; Fernandez-Martin, J; Bald, I; Hernandez-Rodriguez, J; Mendez, M; Dordal, M.T.; Basagana, M; Bujan, S; Yashiro, M; Kubota, T; Koike, R; Akuta, N; Shimoyama, K; Iwata, N; Saito, MK; Ohara, O; Kambe, N; Yasumi, T; Izawa, K; Kawai, T; Heike, T; Yague, J; Nishikomori, R; Arostegui, J.I.

Somatic NLRP3 mosaicism in Muckle-Wells syndrome. A genetic mechanism shared by different phenotypes of cryopyrin-associated periodic syndromes

ANNALS OF THE RHEUMATIC DISEASES, 2015;

FI: 10,377; D1

Riancho-Zarrabeitia, L; Calvo-Rio, V; White, R; Mesquida, M; Adam, AM; Herreras, JM; Aparicio, A; Peiteado-Lopez, D; Lamb-Eat, M; Serrano, JLG; Ortego-Centeno, N; Corn, O; White, A; Sanchez-Burson, J; Gonzalez-Suarez, S; Fonollosa, A; Santos-Gomez, M; Gonzalez-Vela, C; Loricera, J; Pina, T; Gonzalez-Gay, MA

Anti-TNF-alpha therapy in refractory uveitis associated with sarcoidosis: Multicenter study of 17 patients

SEMINARS IN ARTHRITIS AND RHEUMATISM, 2015;

FI: 3,925; Q1

Development of a sex-differentiated cellular atlas of skin tissue in patients with systemic sclerosis by single-cell transcriptome sequencing

Funder: CARLOS III HEALTH INSTITUTE - FEDER

File number: PI22 / 00092

Execution time: 01/01/2023 - 31/12/2025

IP: MARIALBERT ACOSTA HERRERA

AOVELES_Effect of Extra Virgin Olive Oil on Systemic Lupus Erythematosus

Funder: UNIVERSITY OF GRANADA

File number: B-CTS-100-UGR20

Execution time: 01/07/2021 - 30/06/2023

PI: BLANCA MARIA RUEDA MEDINA

Early Detection of Osteoporosis: Identification of Genetic Factors Involved in Bone Mineralization in Young Adults

Funder: FUNDACION PUBLICA ANDALUZA PROGRESO Y SALUD

File number: PI-0414-2014

Execution time: 31/07/2015 - 01/08/2017

PI: BLANCA MARIA RUEDA MEDINA

Identification of Genetic Factors Involved in the Development of Digital Ulcers in Scleroderma Patients Through a Whole Genome Association Study (Gwas)

Funder: FUNDACION PUBLICA ANDALUZA PROGRESO Y SALUD

File number: PI-0390-2014

Execution time: 31/07/2015 - 01/08/2017

Lydimed: Lupus and the Mediterranean Diet

Funder: COUNCIL OF HEALTH

File number: PI-0523-2016

Execution time: 01/01/2017 - 31/12/2019

Identification of Shared Genetic Risk Factors Among Rheumatic Diseases Using a Meta-Immunochip Strategy

Funder: COUNCIL OF HEALTH

File number: PI-0493-2016

Execution time: 01/01/2017 - 31/12/2019

PI: RAQUEL RIOS FERNANDEZ

Study of the molecular basis of giant cell arteritis by integrating genomic, transcriptomic and methylation data.

Funder: CARLOS III HEALTH INSTITUTE - FEDER

File number: CP17 / 00008-P

Execution time: 01/01/2018 - 31/12/2020

Identification of the pathogenic mechanisms involved in the development of giant cell arteritis by single T-cell transcriptome sequencing

Funder: CARLOS III HEALTH INSTITUTE - FEDER

File number: PI18 / 00040

Execution time: 01/01/2019 - 31/12/2021

A phase 2/3, randomized, double-blind, placebo-controlled, parallel-group study to evaluate the efficacy and safety of subcutaneously administered belimumab in adults with systemic sclerosis-associated interstitial lung disease (

Funder: GLAXOSMITHKLINE, SA

Type of test: CLINICAL TRIAL WITH DRUGS

Execution time: 17/07/2023 - 30/05/2027

PI: JOSE LUIS CALLEJAS RUBIO

A randomized, pragmatic, open-label, multicenter phase III trial to evaluate the efficacy and safety of different durations of antimicrobial treatment for osteosynthesis material-associated infections after long bone fracture (DURATIOM)

Funder: SEVILLE HEALTH RESEARCH MANAGEMENT FOUNDATION

Type of test: CLINICAL TRIAL WITH DRUGS

Execution time: 20/06/2023 - 30/10/2024

PI: MARIA CONCEPCION FERNANDEZ ROLDAN

A multicenter, randomized, double-blind, placebo-controlled, 2-stage trial to evaluate the efficacy and safety of placebo-controlled Telitacicept in patients with moderately or severely active systemic lupus erythematosus.

Funder: REMEGEN CO. LTD

Type of test: CLINICAL TRIAL WITH DRUGS

Execution time: 17/02/2023 - 30/01/2024

PI: JOSE LUIS CALLEJAS RUBIO

Phase II, randomized, double-blind, placebo-controlled, parallel-group, efficacy and safety study of at least 48 weeks of treatment with oral BI 685509 in adults with progressive systemic sclerosis.

Financier: BOEHRINGER INGELHEIM ESPAÑA, SA

Type of test: CLINICAL TRIAL WITH DRUGS

Execution time: 20/12/2022 - 30/01/2026

PI: JOSE LUIS CALLEJAS RUBIO

Phase III, multicenter, randomized, double-blind, placebo-controlled study to evaluate the efficacy and safety of BIIB059 in adult participants with active systemic lupus erythematosus receiving standard non-biological lupus treatment as standard (TOPAZ-1)

Funder: BIOGEN IDEC RESEARCH LIMITED

Type of test: COMMERCIAL CLINICAL TRIAL

Execution time: 03/01/2022 - 30/09/2026

PI: JOSE LUIS CALLEJAS RUBIO

A 52-week, randomized, double-blind, double-dummy, parallel-group, multicenter, non-inferiority study to investigate the efficacy and safety of depemokimab compared to mepolizumab in adults with eosinophilic granulomatosis with polyangiitis (EGPA). English) relapsed or refractory who receive standard treatment

Funder: GLAXOSMITHKLINE RESEARCH DEVELOPMENT LTD

Type of test: COMMERCIAL CLINICAL TRIAL

Execution time: 03/08/2022 - 08/10/2025

PI: JOSE LUIS CALLEJAS RUBIO

Sarilumab Clinical Trial in Hospitalized Adults With COVID-19 Presenting Cytokine Release Syndrome (SARICOR)

Funder: UNIVERSITY FOUNDATION FOR THE DEVELOPMENT OF THE PROVINCE OF CORDOBA

Type of test: INDEPENDENT CLINICAL TRIAL

Execution time: 07/05/2020 -

PI: MARIA CONCEPCION FERNANDEZ ROLDAN

CDC Open, multicenter clinical trial to evaluate the effectiveness and safety of intravenous tocilizumab in the treatment of patients with COVID-19 pneumonia. BREATH-19 study

Funder: SEIMC-GESIDA FOUNDATION

Type of test: INDEPENDENT CLINICAL TRIAL

Execution time: 22/05/2020 - 20/11/2020

PI: JOSE LUIS CALLEJAS RUBIO

MP07-Bases Physiopathology and Medical Therapeutics

Research lines

Keywords

SARA DEL OLM ROMERO

MARIA DEL ROCIO GIL GUTIERREZ

MARTA GARCIA MORALES

JAVIER DE LA HERA FERNANDEZ

MARIALBERT ACOSTA HERRERA

ELIO GABRIEL CARMONA RUBIO

JOSE LUIS CALLEJAS RUBIO

MARIA CORREA RODRIGUEZ

MARIA CONCEPCION FERNANDEZ ROLDAN

RACHEL RIOS FERNANDEZ

BLANCA MARIA RUEDA MEDINA

Research