MP06-Clinical and Basic Neurosciences

Information
Members
Publications
Projects
Clinical trials

Basic, clinical and translational research group on neurological diseases, with special dedication to neurodegerative diseases, in addition to other areas such as epilepsy and cerebrovascular diseases. Within neurodegenerative diseases, its main lines address Parkinson's disease and other movement disorders (genetics; mechanisms of neurodegeneration and neuroprotection; biomarkers and molecular biology; surgical treatment and other therapies using devices; early dysfunction of the autonomic nervous system, rhythm monitoring circadians, gait analysis, clinical trials) and Alzheimer's disease and other dementias (cognitive assessment instruments; biomarkers by functional imaging and CSF; psychobiology of learning and memory; cognition and aging).

Research lines

Alzheimer's disease and other dementias.
Parkinson's disease and other movement disorders.
Cerebrovascular diseases
Epilepsy.

Research networks

NEURORECA - Andalusian Network for Clinical and Translational Research in Neurology

Keywords

Molecular biology. Biomarkers. Alzheimer disease. Parkinson's disease. Epilepsy. Dementias Genetics. Ictus. Neurosurgery. Neurology. Neuropsychology. Movement Disorders.

ALICIA BAUTISTA GARCIA

ORCID

JUAN CARLOS ROMERO FABREGA

LORENZO RIVAS GARCIA

CRISTINA DEL TORO PEREZ

ORCID

JOSE MARIA BARRIOS LOPEZ

MAJED JOUMA KATATI

CARLOS JAVIER MADRID NAVARRO

ADOLFO MIGUEZ CASTELLANOS

GONZALO OLIVARES GRANADOS

ORCID

JESUS ANTONIO RUIZ GIMENEZ

SARA BANDRES CIGA

ORCID

RACHEL DURAN OGALLA

ORCID

Be careful, OO; Bandres-Ciga, S; Makarious, MB; Believe, PW; Hernandez, DG; Houlden, H; Rizig, M; Singleton, A.B.; Noyce, A.J.; Nalls, M.A.; Blauwendraat, C; Okubadejo, NU

GBA1 rs3115534 Is Associated with REM Sleep Behavior Disorder in Parkinson's Disease in Nigerians

MOVEMENT DISORDERS, 2024;

FI: 7,4; D1

Romero-Márquez, JM; Navarro-Hortal, MD; Forbes-Hernández, T.Y.; Varela-López, A.; Puentes, J.G.; Sánchez-González, C.; Sumalla-Cano, S.; Battino, M.; García-Ruiz, R.; Sánchez, S.; Quiles, J.L.

Effect of olive leaf phytochemicals on the anti-acetylcholinesterase, anti-cyclooxygenase-2 and ferric reducing antioxidant capacity

FOOD CHEMISTRY, 2024;

FI: 8,5; D1

Navarro-Hortal, MD; Romero-Márquez, JM; López-Bascón, MA; Sánchez-González, C; Xiao, JB; Sumalla-Cano, S; Battino, M; Forbes-Hernández, TY; Quiles, JL

In Vitro and In Vivo Insights into a Broccoli Byproduct as a Healthy Ingredient for the Management of Alzheimer's Disease and Aging through Redox Biology

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2024;

FI: 5,7; D1

Escamilla-Sevilla, F; Freire-Alvarez, E; Castrillo, JCM; Ferro, AS; Santos-García, D

Concerns with the new biological research criteria for synucleinopathy

LANCET NEUROLOGY, 2024;

FI: 46,6; D1

Akcimen, F; van Midden, V; Akerman, S.C.; Makarious, MB; Rothstein, J.D.; Fang, Z.H.; Bandres-Ciga, S

Investigating the Protective Role of the Mitochondrial 2158 T > C Variant in Parkinson's Disease

MOVEMENT DISORDERS, 2024;

FI: 7,4; D1

Rivas-Garcia, L; Navarro-Hortal, MD; Romero-Marquez, JM; Llopis, J; Forbes-Hernández, TY; Xiao, J.B. Quiles, JL; Sanchez-Gonzalez, C

Valorization of Olea europaea and olive oil processing by-products/wastes

VALORIZATION OF WASTE/BY: products in the Design of Functional Foods/Supplements, 2023;

Prieto, I; Segarra, AB; Banegas, I; Duran, R; Vives, F; Dominguez-Vias, G; Ramirez-Sanchez, M

Correlational Study of Aminopeptidase Activities between Left or Right Frontal Cortex versus the Hypothalamus, Pituitary, Adrenal Axis of Spontaneously Hypertensive Rats Treated with Hypotensive or Hypertensive Agents

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023;

FI: 5,6; Q1

Exposito, AN; Vázquez-Agredos, A; Menchén, S; Gámiz, F; Rooster, M

Taste Neophobia, Latent Inhibition of Taste Aversion and Object Recognition Memory in Adolescent Rats

PSYCHOTHEMA, 2023;

FI: 3,6; Q2

Ramirez-Sanchez, M; Prieto, I; Segarra, AB; Banegas, I; Martinez-Cañamero, M; Dominguez-Vias, G; Duran, R; Vives, F; Alba, F

Asymmetric Pattern of Correlations of Leucine Aminopeptidase Activity between Left or Right Frontal Cortex versus Diverse Left or Right Regions of Rat Brains

SYMMETRY-BASEL, 2023;

FI: 2,7; Q2

Triguero-Cueva, L; Marin-Romero, B; Madrid-Navarro, CJ; Perez-Navarro, MJ; Ianez-Velasco, B; Minguez-Castellanos, A; Katati, MJ; Escamilla-Seville, F

Neuropsychological assessment protocol in an ongoing randomized controlled trial on posterior subthalamic area vs. ventral intermediate nucleus deep brain stimulation for essential tremor

FRONTIERS IN NEUROLOGY, 2023;

FI: 3,4; Q2

Bowles, K.R.; Pugh, D.A.; Liu, Y.Y. Patel, T; Renton, A.E.; Bandres-Ciga, S; Gan-Or, Z; Heutink, P; Siitonen, A; Bertelsen, S; Cherry, J.D.; Karch, C.M.; Frucht, S.J.; Kopell, B.H.; Peter, I; Park, Y.J.; Charney, A; Raj, T; Crary, J.F.; Goate, A.M.

17q21.31 sub-haplotypes underlying H1-associated risk for Parkinson's disease are associated with LRRC37A/2 expression in astrocytes

MOLECULAR NEURODEGENERATION, 2022;

FI: 18,879; D1

Romero-Marquez, JM; Navarro-Hortal, MD; Jimenez-Trigo, V; Munoz-Ollero, P; Forbes-Hernandez, T.Y.; Esteban-Munoz, A; Giampieri, F; Noya, ID; Bullon, P; Vera-Ramirez, L; Battino, M; Sanchez-Gonzalez, C; Quiles, J.L.

An Olive-Derived Extract 20% Rich in Hydroxytyrosol Prevents beta-Amyloid Aggregation and Oxidative Stress, Two Features of Alzheimer Disease, via SKN-1/NRF2 and HSP-16.2 in Caenorhabditis elegans

ANTIOXIDANTS, 2022;

FI: 7,675; D1

Bandres-Ciga, S

Black and African American Connections to Parkinson's Disease Study: Addressing Missing Diversity in Parkinson's Disease Genetics

MOVEMENT DISORDERS, 2022;

FI: 9,698; D1

Perinan, MT; Brolin, K; Bandres-Ciga, S; Blauwendraat, C; Klein, C; Gan-Or, Z; Singleton, A; Gomez-Garre, P; Swanberg, M; Mir, P; Noyce, A.

Effect Modification between Genes and Environment and Parkinson's Disease Risk

ANNALS OF NEUROLOGY, 2022;

FI: 11,274; D1

Pihlstrom, L; Fan, C.C.; Frei, O; Tan, M; Karunamuni, R.A.; Blauwendraat, C; Bandres-Ciga, S; Gan-Or, Z; Grosset, DG; Dale, AM; Seibert, TM; Andreassen, OA

Genetic Stratification of Age-Dependent Parkinson's Disease Risk by Polygenic Hazard Score

MOVEMENT DISORDERS, 2022;

FI: 9,698; D1

Storm, CS; Kia, D.A.; Almramhi, MM; Bandres-Ciga, S; Finan, C; Hingorani, A.D.; Wood, N.W.

Finding genetically-supported drug targets for Parkinson's disease using Mendelian randomization of the druggable genome

NATURE COMMUNICATIONS, 2021;

FI: 14,919; D1

Chen, ZB; Zhang, D; Reynolds, R.H.; Gustavsson, EK; Garcia-Ruiz, S; D'Sa, K; Fairbrother-Browne, A; Vandrovcova, J; Hardy, J.; Houlden, H; Taliun, SAG; Botia, J; Ryten, M.

Human-lineage-specific genomic elements are associated with neurodegenerative disease and APOE transcript usage

NATURE COMMUNICATIONS, 2021;

FI: 14,919; D1

Gamiz, F; Rooster, M

A Systematic Review of the Dietary Choline Impact on Cognition from a Psychobiological Approach: Insights from Animal Studies

NUTRIENTS, 2021;

FI: 5,719; Q1

Gutierrez-Romero, L; Rivas-Garcia, L; Sanchez-González, C; Llopis, J; White, E.; Montes-Bayon, M

Cellular Toxicity Mechanisms and the Role of Autophagy in Pt(IV) Prodrug-Loaded Ultrasmall Iron Oxide Nanoparticles Used for Enhanced Drug Delivery

PHARMACEUTICS, 2021;

FI: 6,321; Q1

Grau-Perales, AB; Gamiz, F; Rooster, M

Effect of hippocampal 6-OHDA lesions on the contextual modulation of taste recognition memory

BEHAVIORAL BRAIN RESEARCH, 2021;

FI: 3,332; Q2

Mancebo-Azor, R; Saez-Moreno, J.A.; Rodriguez-Ferrer, J.M.

Cortical Contrast Processing in Retinitis Pigmentosa: Evidence of PVEPs Spatial Functions

EUROPEAN JOURNAL OF RESEARCH IN HEALTH PSYCHOLOGY AND EDUCATION, 2020;

Quiles, JL; Rivas-Garcia, L; Varela-Lopez, A; Llopis, J; Battino, M; Sanchez-Gonzalez, C.

Do nutrients and other bioactive molecules from foods have anything to say in the treatment against COVID-19?

ENVIRONMENTAL RESEARCH, 2020;

FI: 5,715; D1

Bittner, VA; Szarek, M; Aylward, PE; Bhatt, D.L.; Diaz, R; Edelberg, JM; Fras, Z; Goodman, S.G.; Halvorsen, S; Hanotin, C; Harrington, RA; Jukema, JW; Loizeau, V; Moriarty, PM; Moryusef, A; Pordy, R; Roe, M.T.; Sinnaeve, P; Tsimikas, S; Vogel, R; White, HD; Zah

Effect of Alirocumab on Lipoprotein (a) and Cardiovascular Risk After Acute Coronary Syndrome

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2020;

FI: 20,589; D1

Esteban-Parra, GM; San Sebastián, E; Cepeda, J; Sanchez-Gonzalez, C; Rivas-Garcia, L; Llopis, J; Aranda, P; Sanchez-Moreno, M; Quiros, M; Rodriguez-Dieguez, A.

Anti-diabetic and anti-parasitic properties of a family of luminescent zinc coordination compounds based on the 7-amino-5-methyl-1,2,4-triazolo [1,5-alpha] pyrimidine ligand

JOURNAL OF INORGANIC BIOCHEMISTRY, 2020;

FI: 3,212; Q1

Navas, A; Jannus, F; Fernandez, B; Cepeda, J; O'Donnell, MM; Diaz-Ruiz, L; Sanchez-Gonzalez, C; Llopis, J; Seco, JM; Rufino-Palomares, E; Lupianez, JA; Gomez-Ruiz, S; Quiles, JL; Battino, M; Choquesillo-Lazarte, D; Ruiz-Muelle, AB; Fernandez, I; Reyes-Zur

Designing Single-Molecule Magnets as Drugs with Dual Anti-Inflammatory and Anti-Diabetic Effects

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2020;

FI: 4,556; Q1

Cervera-Mata, A; Navarro-Alarcon, M; Slim, G; Pastoriza, S; Montilla-Gomez, J; Llopis, J; Sanchez-Gonzalez, C; Rufian-Henares, J.A.

Spent coffee grounds Improve the nutritional value in elements of lettuce (Lactuca sativa L.) and are an ecological alternative to inorganic fertilizers

FOOD CHEMISTRY, 2019;

FI: 5,399; D1

Fernandez-Santiago, R; Martin-Flores, N; Antonelli, F; Cerquera, C; Moreno, V; Bandres-Ciga, S; Manduchi, E; Tolosa, E; Singleton, AB; Moore, JH; Noyce, AJ; Kaiyrzhanov, R; Middlehurst, B; Kia, DA; Tan, M; Houlden, H; Morris, HR; Plun-Favreau, H; Holmans, P; Hardy, J; Trabzuni, D; Bras, J; Quinn, J; Mok, KY; Kinghorn, KJ; Billingsley, K; Wood, NW; Lewis, P; Schreglmann, S; Guerreiro, R; Lovering, R; R'Bibo, L; Manzoni, C; Rizig, M; Ryten, M; Guelfi, S; Escott-Price, V; Chelban, V; Foltynie, T; Williams, N; Morrison, KE; Clarke, C; Brice, A; Danjou, F; Lesage, S; Corvol, JC; Martinez, M; Schulte, C; Brockmann, K; Simoon-Saanchez, J; Heutink, P; Rizzu, P; Sharma, M; Gasser, T; Nicolas, A; Cookson, MR; Bandres-Ciga, S; Blauwendraat, C; Craig, DW; Faghri, F; Gibbs, JR; Hernandez, DG; Van Keuren-Jensen, K; Shulman, JM; Iwaki, H; Leonard, HL; Nalls, MA; Robak, L; Lubbe, S; Finkbeiner, S; Mencacci, NE; Lungu, C; Singleton, AB; Scholz, SW; Reed, X; Alcalay, RN; Gan-Or, Z; Rouleau, GA; Krohn, L; van Hilten, JJ; Marinus, J; Adarmes-Goomez, AD; Aguilar, I; Alvarez, I; Alvarez, V; Barrero, FJ; Yarza, JAB; Bernal-Bernal, I; Blazquez, M; Bonilla-Toribio, M; Botia, JA; Boungiorno, MT; Buiza-Rueda, D; Camera, A; Carrillo, F; Carrion-Claro, M; Cerdan, D; Clarimon, J; Compta, Y; de la Casa, B; Diez-Fairen, M; Dols-Icardo, O; Duarte, J; Duran, R; Escamilla-Sevilla, F; Ezquerra, M; Happy c; Fernandez, M; Fernandez-Santiago, R; Garcia, C; Garcia-Ruiz, P; Gomez-Garre, P; Heredia, MJG; Gonzalez-Aramburu, I; Pagola, AG; Hoenicka, J; Infante, J; Jesus, S; Jimenez-Escrig, A; Kulisevsky, J; Labrador-Espinosa, MA; Lopez-Sendon, JL; Arregui, ALD; Macias, D; Torres, IM; Marin, J; Marti, MJ; Martinez-Castrillo, C; Mendez-del-Barrio, C; Gonzalez, MM; Mata, M; Minguez, A; Mir, P; Rezola, EM; Munoz, E; Pagonabarraga, J; Pascual-Sedano, B; Pastor, P; Errazquin, FP; Perinan-Bacon, T; Ruiz-Martinez, J; Ruz, C; Rodriguez, AS; Sierra, M; Suarez-Sanmartin, E; Tabernero, C; Tartari, JP; Tejera-Parrado, C; Tolosa, E; Valldeoriola, F; Vargas-Gonzalez, L; Candle, L; You live, F; Zimprich, A; Pihlstrom, L; Toft, M; Koks, S; Taba, P; Hassin-Baer, S; Marti, MJ; Ezquerra, M; Malagelada, C

SNCA and mTOR Pathway Single Nucleotide Polymorphisms Interact to Modulate the Age at Onset of Parkinson's Disease

MOVEMENT DISORDERS, 2019;

FI: 8,222; D1

Bandres-Ciga, S; Saez-Atienzar, S; Bonet-Ponce, L; Billingsley, K; Vitale, D; Blauwendraat, C; Gibbs, JR; Pihistrom, L; Gan-Or, Z; Cookson, M.R.; Nails, MA; Singleton, AB

The endocytic membrane trafficking pathway plays a major role in the risk of Parkinson's disease

MOVEMENT DISORDERS, 2019;

FI: 8,222; D1

Martinez, R.; Kapravelou, G; Lopez-Chaves, C; Caceres, E.; Coll-Risco, I; Sanchez-González, C; Llopis, J; Arrebola, F; Galisteo, M; Aranda, P; Lopez-Jurado, M; Porres, J.M.

Aerobic interval exercise improves renal function and affects mineral metabolism in obese Zucker rats

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2019;

FI: 3,323; Q1

Madrid-Navarro, CJ; It costs, FJP; Escamilla-Sevilla, F; Fields, M; Abellan, FR; Role, MA; Madrid, JA

Validation of a Device for the Ambulatory Monitoring of Sleep Patterns: A Pilot Study on Parkinson's Disease

FRONTIERS IN NEUROLOGY, 2019;

FI: 2,635; Q2

Kia, DA; Saber, M.S.; Ahmed, S; Trinh, J; Bandres-Ciga, S.

LRP10 in alpha-synucleinopathies

LANCET NEUROLOGY, 2018;

FI: 27,144; D1

Pihlstrom, L; Blauwendraat, C; Cappelletti, C; Berge-Seidl, V; Langmyhr, M; Henriksen, SP; van de Berg, WDJ; Gibbs, JR; Cookson, M.R.; Singleton, AB; Nalls, MA; Toft, M.

A comprehensive analysis of SNCA-related genetic risk in sporadic parkinson disease

ANNALS OF NEUROLOGY, 2018;

FI: 10,25; D1

Fernandez, JG; Sanchez-Gonzalez, C; Bettmer, J; Llopis, J; Jakubowski, N; Panne, U; Montes-Bayon, M.

Quantitative assessment of the metabolic products of iron oxide nanoparticles to be used as iron supplements in cell cultures

CHEMICAL ANALYTICS ACTA, 2018;

FI: 5,123; D1

Giamperi, F; Quiles, JL; Orantes-Bermejo, FJ; Gasparrini, M; Forbes-Hernandez, T.Y.; Sanchez-Gonzalez, C; Llopis, J; Rivas-Garcia, L; Afrin, S; Varela-Lopez, A; Cianciosi, D; Reboredo-Rodriguez, P; Fernandez-Pinar, CT; Iglesias, RC; Ruiz, R; Aparicio, S; Crespo, J; Lopez, LD; Xiao, J; Battino, M.

Are by-products from beeswax recycling process a new promising source of bioactive compounds with biomedical properties?

FOOD AND CHEMICAL TOXICOLOGY, 2018;

FI: 3,977; D1

Lopez-Chaves, C; Soto-Alvaredo, J; Montes-Bayon, M; Bettmer, J; Llopis, J; Sanchez-Gonzalez, C.

Gold nanoparticles: Distribution, bioaccumulation and toxicity. In vitro and in vivo studies

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, 2018;

FI: 6,5; D1

Morels, E; Gomez-Chacon, B; Rooster, M

Flavor and object recognition memory impairment induced by excitotoxic lesions of the perirhinal cortex

NEUROBIOLOGY OF LEARNING AND MEMORY, 2017;

FI: 3,543; D1

Gil-Montoya, J.A.; Sanchez-Lara, I; Carnero-Pardo, C; Fornieles-Rubio, F; Montes, J; Barrios, R; Gonzalez-Moles, MA; Well done, M.

Oral Hygiene in the Elderly with Different Degrees of Cognitive Impairment and Dementia

JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, 2017;

FI: 4,388; D1

Gil-Montoya, J.A.; Barrios, R; Santana, S; Sanchez-Lara, I; Pardo, C.C.; Fornieles-Rubio, F; Montes, J; Ramirez, C; Gonzalez-Moles, MA; Burgos, JS

Association Between Periodontitis and Amyloid beta Peptide in Elderly People With and Without Cognitive Impairment

JOURNAL OF PERIODONTOLOGY, 2017;

FI: 3,03; Q1

Banegas, I; Prieto, I; Segarra, AB; You live, F; de Gasparo, M; Duran, R; Luna, JD; Ramirez-Sanchez, M

Bilateral distribution of enkephalinase activity in the medial prefrontal cortex differs between WKY and SHR rats unilaterally lesioned with 6-hydroxydopamine

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 2017;

FI: 4,187; Q1

Soto-Alvaredo, J; Lopez-Chaves, C; Sanchez-Gonzalez, C; Montes-Bayon, M; Llopis, J; Bettmer, J.

Speciation of gold nanoparticles and low-molecular gold species in Wistar rat tissues by HPLC coupled to ICP-MS

JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY, 2017;

FI: 3,379; Q1

Bandres-Ciga, S; Price, TR; Barrero, FJ; Escamilla-Sevilla, F; Pelegrina, J; Arepalli, S; Hernandez, D; Gutierrez, B; Cervilla, J; Rivera, M; Rivera, A; Ding, JH; You live, F; Nalls, M; Singleton, A; Duran, R

Genome-wide assessment of Parkinson's disease in a Southern Spanish population

NEUROBIOLOGY OF AGING, 2016;

FI: 5,153; D1

Martin, IT; Avila, RD; Herrera, MZ; Arregui, G; Osorio-Ceballos, JL; Rojas, ES; Almansa, AH; Arrebola, JP; Rull, JP; Hernandez, JE; Ramirez, THE

Role of radiosurgery in the management of glomus tumors

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK, 2016;

FI: 2,76; D1

Bandres-Ciga, S; Mencacci, NE; Duran, R; Barrero, FJ; Escamilla-Sevilla, F; Morgan, S; Hehir, J; You live, F; Hardy, J; Pittman, AM

Analysis of the genetic variability in Parkinson's disease from Southern Spain

NEUROBIOLOGY OF AGING, 2016;

FI: 5,153; D1

Gomez-Rio, M; Knight, MM; Saez, JMG; Minguez-Castellanos, A

Diagnosis of Neurodegenerative Diseases: The Clinical Approach

CURRENT ALZHEIMER RESEARCH, 2016;

FI: 3,145; Q2

Villanueva, V; Saiz-Diaz, R; Toledo, M; Piera, A; Mauri, JA; Rodriguez-Uranga, JJ; Lopez-Gonzalez, FJ; Gomez-Ibanez, A; Garces, M; de la Aleja, JG; Rodriguez-Osorio, X; Palao-Duarte, S; Castillo, A; Bonet, M; Ruiz-Gimenez, J; Palau, J; Archdeacon, A; Toledo, M; Gago, A

NEOPLASM study: Real-life use of lacosamide in patients with brain tumor-related epilepsy

EPILEPSY & BEHAVIOR, 2016;

FI: 2,332; Q2

Antonio-Rubio, I; Madrid-Navarro, CJ; Salazar-Lopez, E; Perez-Navarro, MJ; Saez-Zea, C; Gomez-Milan, E; Minguez-Castellanos, A; Escamilla-Seville, F.

Abnormal thermography in Parkinson's disease

PARKINSONISM & RELATED DISORDERS, 2015;

FI: 3,972; Q1

Ram-Pardo, C

Reasons for withdrawing the Mini-Mental state examination

NEUROLOGY, 2015;

FI: 2,706; Q1

Gil-Montoya, J.A.; Sanchez-Lara, I; Carnero-Pardo, C; Fornieles, F; Montes, J; Vilchez, R; Burgos, JS; Gonzalez-Moles, MA; Barrios, R; Well done, M.

Is Periodontitis a Risk Factor for Cognitive Impairment and Dementia? A Case-Control Study

JOURNAL OF PERIODONTOLOGY, 2015;

FI: 3,833; Q1

Sanchez-Alvarez, JC; Ramos-Lizana, J; Machado-Casas, IS; Serrano-Castro, PJ; Martinez-Anton, JL; Ruiz-Gimenez, J.

Combined treatment with antiepileptic drugs. Andalusian Epilepsy Guide 2015

JOURNAL OF NEUROLOGY, 2015;

FI: 1,063; Q3

Herrera-Garcia, JD; Maestre-Moreno, J.F.

Deep vein thrombosis and dural fistula: a case with infrequent clinical characteristics

JOURNAL OF NEUROLOGY, 2015;

FI: 0,83; Q4

Set_my_DBS: A multicenter study to develop quantitative methods to assist in programming deep brain stimulation systems in patients with Parkinson's disease

Funder: CARLOS III HEALTH INSTITUTE - FEDER

File number: PI23 / 01880

Execution time: 01/01/2024 - 31/12/2026

IP: CARLOS JAVIER MADRID NAVARRO

Involvement of GBA and LRRK2 in the autophagy-lysosome pathway and their role in the pathogenesis of Parkinson's disease.

Funder: UNIVERSITY OF GRANADA

File number: B-CTS-702-UGR20

Execution time: 01/07/2021 - 30/06/2023

IP: RAQUEL DURAN OGALLA

Double-blind crossover randomized clinical trial: deep brain stimulation of the posterior subthalamic area vs. thlamic intermediate ventral nucleus in essential tremor

Funder: CARLOS III HEALTH INSTITUTE - FEDER

File number: PI19 / 01571

Execution time: 01/01/2020 - 31/12/2022

IP: MAJED JOUMA KATATI

Multicenter, cross-sectional observational study to describe the impact of early motor and non-motor fluctuations in patients with Parkinson's disease. IMPACT-PD study.

Funder: ADKNOMA HEALTH RESEARCH, SL

Test type: OBSERVATIONAL STUDY WITH MEDICINES

Execution time: 05/06/2024 - 30/05/2025

PI: FRANCISCO ESCAMILLA SEVILLA

Cross-sectional study to evaluate the efficacy and safety of Ofatumumab (Kesimpta®) in patients with relapsing multiple sclerosis in Spanish clinical practice: CRONOS-MS study

Funder: NOVARTIS FARMACEUTICA, SA

Test type: OBSERVATIONAL STUDY WITH MEDICINES

Execution time: 29/01/2024 - 30/03/2025

PI: FRANCISCO JAVIER BARRERO HERNANDEZ

Multicenter, randomized, double-blind, parallel clinical trial evaluating the efficacy and safety of safinamide versus rasagiline in fatigue associated with Parkinson's disease.

Funder: INSTITUT DE RECERCA DE L´HOSPITAL D

Type of test: CLINICAL TRIAL WITH DRUGS

Execution time: 13/02/2024 - 30/06/2025

PI: FRANCISCO ESCAMILLA SEVILLA

Long-term, Phase 2, global, multicenter safety study designed to evaluate the safety and tolerability of BHV-7000 in subjects with refractory focal-onset epilepsy.

Financier: PHARMACEUTICAL PRODUCT DEVELOPMENT SPAIN SL

Type of test: CLINICAL TRIAL WITH DRUGS

Execution time: 18/09/2024 - 30/01/2027

IP: JESUS ANTONIO RUIZ GIMENEZ

A phase 2/3, multicenter, randomized, double-blind, placebo-controlled study to evaluate the efficacy, safety, and tolerability of BHV-7000 in subjects with refractory focal-onset epilepsy.

Financier: PHARMACEUTICAL PRODUCT DEVELOPMENT SPAIN SL

Type of test: CLINICAL TRIAL WITH DRUGS

Execution time: 20/06/2024 - 30/01/2026

IP: JESUS ANTONIO RUIZ GIMENEZ

Multicenter observational study to describe the persistence in patients with relapsing-remitting multiple sclerosis with low to moderate activity without previous treatment, who have started treatment with Ozanimod (Zeposia®) in clinical practice

Financier: BRISTOL-MYERS SQUIBB, SAU

Type of test: OBSERVATIONAL STUDY WITH MEDICATION

Execution time: 05/05/2023 - 30/06/2026

PI: FRANCISCO JAVIER BARRERO HERNANDEZ

Global real-life evidence study on the long-term effectiveness of duodopa (solution) for infusion in advanced Parkinson's disease in routine clinical practice (ROSSINI: Real-life results with continuous subcutaneous infusion)

Funder: ABBVIE SPAIN SLU

Type of test: OBSERVATIONAL STUDY WITH MEDICATION

Execution time: 21/12/2023 - 30/11/2028

PI: FRANCISCO ESCAMILLA SEVILLA

Retrospective observational study to evaluate the use of siponimod (MAyzent) in patients with Secondary Progressive Multiple Sclerosis in routine clinical practice in Spain. RESYZE Study

Funder: NOVARTIS FARMACEUTICA, SA

Type of test: OBSERVATIONAL STUDY WITH MEDICATION

Execution time: 12/09/2022 - 30/09/2023

PI: FRANCISCO JAVIER BARRERO HERNANDEZ

Multinational, observational and non-interventional study of 12 months to evaluate the effectiveness, tolerability and quality of life of brivaracetam as add-on therapy to previous lines of treatment in adult patients with a history of seizures

Funder: UCB BIOSCIENCES GMBH

Type of test: COMMERCIAL POST AUTHORIZATION STUDY

Execution time: 02/06/2021 - 30/12/2023

IP: JESUS ANTONIO RUIZ GIMENEZ

Prospective, non-interventional, observational and multicenter study to investigate the dose, efficacy and safety of perampanel when used as a first adjunct treatment in the routine clinical care of patients older than 1

Funder: EISAI LTD.

Type of test: COMMERCIAL POST AUTHORIZATION STUDY

Execution time: 01/02/2020 - 30/04/2022

IP: JESUS ANTONIO RUIZ GIMENEZ

Non-interventional and cross-sectional study to evaluate the functional impact of newly diagnosed relapsing remitting multiple sclerosis from the perspective of patients (MS-ONSET Study)

Financier: ROCHE FARMA, SA

Type of test: COMMERCIAL POST AUTHORIZATION STUDY

Execution time: 23/07/2020 - 30/09/2021

PI: FRANCISCO JAVIER BARRERO HERNANDEZ

Study to improve the identification of patients who are candidates for second-line therapies (SLT) in Parkinson's disease. DELIST-PD STUDY

Funder: FOUNDATION OF THE SPANISH SOCIETY OF NEUROLOGY

Type of test: INDEPENDENT POST-AUTHORIZATION STUDY

Execution time: 27/10/2020 - 30/06/2021

PI: FRANCISCO ESCAMILLA SEVILLA

Phase II, Randomized, Double-Blind, Placebo-Controlled Study of K0709 in Patients with Early Parkinson's Disease

Funder: SUN PHARMA ADVANCE RESEARCH

Type of test: COMMERCIAL CLINICAL TRIAL

Execution time: 31/01/2020 - 30/06/2021

PI: ADOLFO MINGUEZ CASTELLANOS

Open-label extension study of Study M15-741 to evaluate the safety and tolerability of daily exposure for 24 hours of continuous subcutaneous infusion of ABBV-951 in patients with Parkinson's disease

Funder: ABBVIE DEUTSCHLAND GMBH & CON K. G

Type of test: COMMERCIAL CLINICAL TRIAL

Execution time: 30/06/2020 - 28/02/2023

PI: FRANCISCO ESCAMILLA SEVILLA

Phase IIb dose-finding study to evaluate the safety and efficacy of Bavisant in the treatment of excessive daytime comnolence (EDS) in patients with Parkinson's disease (PD). CASPAR study

Funder: BENEVOLENTAI BIO

Type of test: COMMERCIAL CLINICAL TRIAL

Execution time: 30/10/2018 - 30/03/2020

PI: ADOLFO MINGUEZ CASTELLANOS

MP06-Clinical and Basic Neurosciences

Research lines

Research networks

Keywords

ALICIA BAUTISTA GARCIA

JUAN CARLOS ROMERO FABREGA

LORENZO RIVAS GARCIA

CRISTINA DEL TORO PEREZ

JOSE MARIA BARRIOS LOPEZ

CLARA RUZ ILLESCAS

RACHEL PINAR MORALES

LUCIA TRIGUERO CAVE

CRISTINA SANCHEZ GONZALEZ

FRANCISCO VIVES MONTERO

FRANCISCO JAVIER BARRERO HERNANDEZ

FRANCISCO ESCAMILLA SEVILLE

MIRACLES GALLO TORRE

MAJED JOUMA KATATI

CARLOS JAVIER MADRID NAVARRO

ADOLFO MIGUEZ CASTELLANOS

GONZALO OLIVARES GRANADOS

JESUS ​​ANTONIO RUIZ GIMENEZ

SARA BANDRES CIGA

RACHEL DURAN OGALLA

Research

JESUS ANTONIO RUIZ GIMENEZ