MP04-Immunogenetics Systemic and Skin Diseases

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Patents
Publications
Clinical trials

Historically, precision medicine in hematology has focused on using real-world data (RWD) generated by the healthcare ecosystem to identify people at risk of developing cancer or even to characterize those patients at higher risk of cancer progression. the illness. This strategy allows for clinical interventions that reduce the risk of disease onset or treatment failure and relapse.

Our group aims to establish proposals for strategies for primary and secondary prevention of hematological malignancies and prevention of disease progression. We base our strategies on risk profiles that integrate biomarkers identified from the fields of genomics, epigenomics, and proteomics, in combination with microbiome, environmental, and lifestyle factors throughout the natural history of each specific hematologic malignancy. Although it is evident that the environment plays an important role in the development of hematological malignancies, as demonstrated by the marked increase in incidence in recent decades, few environmental risk factors have been identified to date, making primary prevention difficult. . This also means that it is not currently possible to stratify patients according to relevant etiological and clinical characteristics. A comprehensive integration of OMIC data with microbiome, environmental, and lifestyle factors in risk profiles has the potential to address this knowledge gap. Furthermore, this approach could ultimately provide individualized tools for prevention and risk stratification, improve early diagnosis of hematologic malignancies (particularly for aggressive subtypes with rapid disease progression), and open new avenues to improve treatment. .

Research lines

Strategic research line 1: Precision medicine: Development of tools for early diagnosis, patient monitoring and disease prognosis.
Secondary strategic line: Cancer genomics
Longitudinal and multi-OMIC approaches for hematological malignancies.
Genetics of premalignant monoclonal B-cell disorders: MGUS and MBL.
Genetic bases of susceptibility to Invasive Fungal Infections in hematological patients.
Genetics of autoimmune diseases: Rheumatoid Arthritis and Ankylosing Spondylitis
Genetics and genomics of solid tumors: colorectal, pancreatic and prostate cancer.
Genetics and immune response to COVID-19 vaccination.

Research networks

CRuCIAL (Chronic Lymphocytic Leukemia)
NuCLEAR (Acute Myeloid Leukemia)
aspBIOmics (invasive fungal infections)
IMPULSE (Myeloproliferative neoplasms)
MIRACLE (Myeloproliferative neoplasms)
REPAIR (Rheumatoid arthritis and ankylosing spondylitis)

Keywords

Genetics, genomics, multi-OMIC approaches, molecular risk scores, hematological malignancies, solid tumors, immune-mediated diseases and invasive infections.

ADORATION HERNANDEZ VIDAÑA

MARIA JOSE PEREZ GALAN

MARIA ELENA CORNEJO CALVO

ANGELA MARTINEZ HELLIN

EVA MARIA PEREZ GUTIERREZ

PALOMA GARCIA MARTIN

MARIA JOSE HAIR TAPIA

MIGUEL ANGEL LOPEZ NEVOT

ORCID

RAPHAEL CALIZ CALIZ

MIGUEL ANGEL FERRER GONZALEZ

ORCID

JUAN SAINZ PEREZ

ORCID

Inventors: MIGUEL ANGEL LOPEZ NEVOT, JOSEFA LEON LOPEZ, ANA GILA MEDINA, JOSÉ ANTONIO MUÑOZ GÁMEZ, ROSA QUILES PÉREZ, PALOMA MUÑOZ DE RUEDA, ÁNGEL CARAZO GALLEGO, ESTHER JOSÉ PAVÓN CASTILLERO, ANA BELÉNIO MUÑOZ SALMON ESCO
Title: POLYMORPHISMS TO PREDICT OR FORECAST THE RESPONSE TO ANTIVIRAL TREATMENT
Code: P201430205

Inventors: JAVIER SALMERÓN ESCOBAR; PALOMA MUÑOZ DE RUEDA; ROSA QUILES PÉREZ; JOSE ANTONIO MUÑOZ GAMEZ; ESTHER JOSÉ PAVÓN CASTILLERO; ANA GILA MEDINA; MIGUEL ANGEL LOPEZ NEVOT; JORGE CASADO RUIZ; ANGELES RUIZ LEIZÓN EXTREMERA; ANA GILA CARRENO ANGELES;
Title: Specific mutations (L5P; L7P; L15S) in the immunodominant epitope HCV-NS3 (aa 1253-1272) against HLA-DQB1 * 0301 cause a non-response to antiviral treatment with pegIFN / RBV in patients with Chronic Hepatitis C genotype
Code: P-06781

Inventors: JOSE ANTONIO LOPEZ ESCAMEZ, MIGUEL ANGEL LOPEZ NEVOT, IRENE GAZQUEZ PEREZ
Title: METHOD OF OBTAINING USEFUL DATA FOR THE DIAGNOSIS AND PROGNOSIS OF NEUROSENSORY HEARING
Code: P201132013

González-Olmedo, C; García-Verdejo, FJ; Reguera-Teba, A; Rosa-Garrido, C; López-López, J.A.; Díaz-Beltrán, L.; García, PM; Luque-Caro, N; Gálvez-Montosa, F; Ortega-Granados, A.L.; Ruiz-Sanjuan, M; Cózar-Ibáñez, A; Sainz, J; Marchal, J.A.; Camacho, J; del Palacio, J.P.; Fernández-Godino, R; Díaz, C; Sánchez-Rovira, P

Metabolomics signature as a survival predictor in patients with resectable colorectal liver metastasis

CLINICAL AND TRANSLATIONAL MEDICINE, 2024;

FI: 7,9; D1

Yasser, Y.K. Gil, D; Zentar, H; Durán-Peña, MJ; Prados-Lopez, B; Juárez-Moreno, J; Botubol-Ares, JM; Haidour, A; Sainz, J; Fernandez, A; Alvarez-Manzaneda, R; Chahboun, R; Reyes-Zurita, F.J.

Semisynthesis and Antitumor Evaluation of Natural Derivatives from ent-Kaurene ent-15α-Angeloyloxykaur-l6-en-3β-ol Isolated from Distichoselinum tenuifolium

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2024;

FI: 4,9; Q1

Gutiérrez-Bautista, J.F.; Sampedro, A.; Ballesta-Alcaraz, L.; Aguilera-Franco, M.; Olivares-Duran, M.J.; Cobo, F.; Reguera, J.A.; Rodríguez-Granger, J.; Torres-Llamas, A.; Martín-Sánchez, J.; Aznar-Peralta, I.; Vilchez, J.R.; López-Nevot, M.A.; Sampedro-Martínez, A.

Analysis of HLA Alleles in Different Cohorts of Patients Infected by L. infantum from Southern Spain

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2024;

FI: 4,9; Q1

García-García, A; Medina-O'donnell, M; Rojas, S; Cano-Morenilla, M; Morales, J; Quesada-Moreno, M; Sainz, J; Vitorica-Yrezabal, IJ; Rodríguez-Diéguez, A; Navarro, A; Reyes-Zurita, FJ

Modulating anti-inflammatory and anticancer properties by designing a family of metal-complexes based on 5-nitropicolinic acid

DALTON TRANSACTIONS, 2024;

FI: 3,5; Q2

Díaz-Alberola, I; Espuch-Oliver, A; Fernández-Segovia, F; López-Nevot, MA

Possible Role of Cytomegalovirus in Gastric Cancer Development and Recurrent Macrolide-Resistant Campylobacter jejuni Infection in Common Variable Immunodeficiency: A Case Report and Literature Discussion

MICROORGANISMS, 2024;

FI: 4,1; Q2

Redruello-Romero, A; Benitez-Cantos, MS; Lopez-Perez, D; Garcia-Rubio, J; Tamayo, F; Perez-Bartivas, D; Moreno-SanJuan, S; Ruiz-Palmero, I; Puentes-Pardo, JD; Vilchez, JR; Lopez-Nevot, MA; Garcia, F; Cano, C; Leon, J; Carazo, A

Human adipose tissue as a major reservoir of cytomegalovirus-reactive T cells

FRONTIERS IN IMMUNOLOGY, 2023;

FI: 7,3; Q1

Cabrera-Serrano, AJ; Sanchez-Maldonado, JM; ter Horst, R; Macauda, A; Garcia-Martin, P; Benavente, Y; Landi, S; Clay-Gilmour, A; Niazi, Y; Espinet, B; Rodriguez-Sevilla, JJ; Perez, EM; Maffei, R; Blanco, G; Giaccherini, M; Cerhan, JR; Marasca, R; Lopez-Neiman, J;

Do GWAS-Identified Risk Variants for Chronic Lymphocytic Leukemia Influence Overall Patient Survival and Disease Progression?

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023;

FI: 5,6; Q1

Muñoz-Herrera, CM; Gutiérrez-Bautista, JF; López-Nevot, MA

Complement Binding Anti-HLA Antibodies and the Survival of Kidney Transplantation

JOURNAL OF CLINICAL MEDICINE, 2023;

FI: 3,9; Q2

Ruiz, OG; Sanchez-Maldonado, JM; Lopez-Nevot, MA; Garcia, P; Macauda, A; Hernandez-Mohedo, F; Gonzalez-Sierra, PA; Martinez-Bueno, M; Perez, E; Reyes-Zurita, FJ; Campa, D; Canzian, F; Jury, M; Rodriguez-Sevilla, JJ; Sainz, J.

Autophagy in Hematological Malignancies

CANCER, 2022;

FI: 6,575; Q1

Gutierrez-Bautista, JF; Martinez-Chamorro, A; Rodriguez-Nicolas, A; Rosales-Castillo, A; Jimenez, P; Anderson, P; Lopez-Ruz, MA; Lopez-Nevot, MA; Ruiz-Cabello, F

Major Histocompatibility Complex Class I Chain-Related alpha (MICA) STR Polymorphisms in COVID-19 Patients

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2022;

FI: 6,208; Q1

Gutierrez-Bautista, JF; Rodriguez-Nicolas, A; Rosales-Castillo, A; Lopez-Ruz, MA; Martin-Casares, AM; Fernandez-Rubiales, A; Anderson, P; Garrido, F; Ruiz-Cabello, F; Lopez-Nevot, MA

Study of HLA-A,-B,-C,-DRB1 and-DQB1 polymorphisms in COVID-19 patients

JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION, 2022;

FI: 10,273; Q1

Sanchez-Maldonado, JM; Collado, R; Cabrera-Serrano, AJ; Ter Horst, R; Galvez-Montosa, F; Robles-Fernandez, I; Arenas-Rodriguez, V; Cano-Gutierrez, B; Bakker, O; Bravo-Fernandez, MI; Garcia-Verdejo, FJ; Lopez, JAL; Olivares-Ruiz, J; Lopez-Nevot, MA; Fernandez-Puerta, L; Cozar-Olmo, JM; Li, Y; Netea, MG; Jury, M; Lorente, JA; Sanchez-Rovira, P; Alvarez-Cubero, MJ; Sainz, J.

Type 2 Diabetes-Related Variants Influence the Risk of Developing Prostate Cancer: A Population-Based Case-Control Study and Meta-Analysis

CANCER, 2022;

FI: 6,575; Q1

Garcia-Martin, P; Ten am; Maldonado, JMS; Serrano, AJC; ter Horst, R; Benavente, Y; Landi, S; Macauda, A; Clay-Gilmour, A; Hernandez-Mohedo, F; Niazi, Y; Gonzalez-Sierra, P; Espinet, B; Rodriguez-Sevilla, JJ; Maffei, R; White, G; Giaccherini, M; Puiggros, A; Cerhan, J; Marasca, R; Canadas-Garre, M; Lopez-Nevot, MA; Chen-Liang, T; Thomsen, H; Gamez, I; Moreno, V; Marcos-Gragera, R; Garcia-Alvarez, M; Llorca, J; Jerez, A; Berndt, S; Butrym, A; Norman, A.D.; Casabonne, D; Luppi, M; Slager, SL; Hemminki, K; Li, Y; Alcoceba, M; Campa, D; Canzian, F; de Sanjose, S; Forsti, A; Netea, MG; Jury, M; Sainz, J.

Validation and functional characterization of GWAS-identified variants for chronic lymphocytic leukemia: a CRuCIAL study

BLOOD CANCER JOURNAL, 2022;

FI: 9,812; Q1

Munoz-Herrera, CM; Gutierrez-Bautista, JF; Lopez-Nevot, MA

Clinical Case: Patient with Mixed Graft Rejection Four Days after Kidney Transplantation Developed Specific Antibodies against Donor Bw4 Specificities.

ANTIBODIES, 2021;

Sanchez-Maldonado, JM; Moniz-Diez, A; ter Horst, R; Campa, D; Cabrera-Serrano, AJ; Martinez-Bueno, M; Garrido-Collado, MD; Hernandez-Mohedo, F; Fernandez-Puerta, L; Lopez-Nevot, MA; Cunha, C; Gonzalez-Sierra, PA; Springer, J.; Lackner, M; Alcazar-Fuoli, L;

Polymorphisms within the TNFSF4 and MAPKAPK2 Loci Influence the Risk of Developing Invasive Aspergillosis: A Two-Stage Case Control Study in the Context of the aspBIOmics Consortium

JOURNAL OF FUNGI, 2021;

FI: 5,816; Q1

Sanchez-Maldonado, JM; Chalice, R; Lopez-Nevot, MA; Cabrera-Serrano, AJ; Moniz-Diez, A; Canhao, H; Ter Horst, R; Quartuccio, L.; Sorensen, S.B.; Glintborg, B; Hetland, ML; Filipescu, I; Perez-Pampin, E; Conesa-Zamora, P; Swierkot, J; den Broeder, AA; De Vita,

Validation of GWAS-Identified Variants for Anti-TNF Drug Response in Rheumatoid Arthritis: A Meta-Analysis of Two Large Cohorts

FRONTIERS IN IMMUNOLOGY, 2021;

FI: 7,561; Q1

Montoyo-Pujol, YG; Wang, X; Bermudez-Sanchez, S; Martina; Almazan, F; Lopez-Nevot, MA

Measurement of 45 cytokine, chemokine and growth factors in established cell culture supernatants and autologous serum from advanced melanoma patients

CARCINOGENESIS, 2021;

FI: 4,944; Q2

Wang, X; Montoyo-Pujol, YG; Bermudez, S; Corpas, G; Martina; Almazan, F; Cabrera, T.; Lopez-Nevot, MA

Serum Cytokine Profiles of Melanoma Patients and Their Association with Tumor Progression and Metastasis

JOURNAL OF ONCOLOGY, 2021;

FI: 4,375; Q2

Sanchez-Maldonado, JM; Campa, D; Springer, J; Badiola, J; Niazi, Y; Moniz-Diez, A; Hernandez-Mohedo, F; Gonzalez-Sierra, P; Ter Horst, R; Macauda, A; Brezina, S; Cunha, C; Lackner, M; Lopez-Nevot, MA; Fianchi, L; Pagano, L; Lopez-Fernandez, E; Potenza, L;

Host immune genetic variations influence the risk of developing acute myeloid leukemia: results from the NuCLEAR consortium

BLOOD CANCER JOURNAL, 2020;

FI: 8,023; D1

Sanchez-Maldonado, JM; Martinez-Bueno, M; Canhao, H; ter Horst, R; Munoz-Pena, S; Moniz-Diez, A; Rodriguez-Ramos, A; Squire, A; Sorensen, S.B.; Hetland, M.L.; Ferrer, MA; Glintborg, B; Filipescu, I; Perez-Pampin, E; Conesa-Zamora, P; Garcia, A; den Broeder,

NFKB2 polymorphisms associated with the risk of developing rheumatoid arthritis and response to TNF inhibitors: Results from the REPAIR consortium

SCIENTIFIC REPORTS, 2020;

FI: 3,998; Q1

Lupianez, C.B.; Martinez-Bueno, M; Sanchez-Maldonado, JM; Badiola, J; Cunha, C; Springer, J; Lackner, M; Segura-Catena, J; Canet, LM; Alcazar-Fuoli, L; Lopez-Nevot, MA; Fianchi, L; Aguado, JM; Pagan, L; Lopez-Fernandez, E; Alarcon-Riquelme, M; Potenza, L;

Polymorphisms within the ARNT2 and CX3CR1 Genes Are Associated with the Risk of Developing Invasive Aspergillosis

INFECTION AND IMMUNITY, 2020;

FI: 3,201; Q2

Gamez, CGM; Chamorro, AM; Casares, WMA; Sanchez, JT; Arias-Santiago, S; Garcia-Lora, E; Lopez-Nevot, MA

Joint study of the associations of HLA-B and the transmembrane short tandem repeat polymorphism of MICA protein with alopecia areata shows independent associations of both with the disease

CLINICAL AND EXPERIMENTAL DERMATOLOGY, 2020;

FI: 1,977; Q3

Sanchez-Maldonado, JM; Caliz, R; Channel; ter Horst, R; Bakker, O; den Broeder, AA; Martinez-Bueno, M; Canhao, H; Rodriguez-Ramos, A; Lupianez, CB; Soto-Pino, MJ; Garcia, A; Perez-Pampin, E; Gonzalez-Utrilla, A; Escudero, LA; Segura-Catena, J; Netea-Maier, RT; Ferrer, MA; Collantes-Estevez, E; Nevot, MAL; Li, Y; Jurado, M; Fonseca, JE; Netea, MG; Coenen, MJH; Sainz, J

Steroid hormone-related polymorphisms associated with the development of bone erosions in rheumatoid arthritis and help to predict disease progression: Results from the REPAIR consortium

SCIENTIFIC REPORTS, 2019;

FI: 4,011; Q1

Aliaga, L; Ceballos, J; Sampedro, A; Cobo, F; Lopez-Nevot, MA; Merino-Espinosa, G; Morillas-Marquez, F; Martin-Sanchez, J.

Asymptomatic Leishmania infection in blood donors from the Southern of Spain

INFECTION, 2019;

FI: 2,927; Q2

Porrino-Bustamante, ML; Lopez-Nevot, MA; Aneiros-Fernandez, J; Married-Ruiz, J; Garcia-Linares, S; Pedrinacci-Rodriguez, S; Garcia-Lora, E; Martin-Casares, MA; Fernandez-Pugnaire, MA; Arias-Santiago, S.

Study of Human Leukocyte Antigen (HLA) in 13 cases of familial frontal fibrosing alopecia: CYP21A2 gene p.V281L mutation from congenital adrenal hyperplasia linked to HLA class I haplotype HLA-A * 33: 01; B * 14: 02; C * 08: 02 as a genetic marker

AUSTRALIAN JOURNAL OF DERMATOLOGY, 2019;

FI: 1,701; Q3

Porrino-Bustamante, ML; Lopez-Nevot, MA; Aneiros-Fernandez, J; Garcia-Lora, E; Fernandez-Pugnaire, MA; Arias-Santiago, S.

Familial frontal fibrosing alopecia: A cross-sectional study of 20 cases from nine families

AUSTRALIAN JOURNAL OF DERMATOLOGY, 2019;

FI: 1,701; Q3

Mannose, M; Calafat, M; de Francisco, R; Garcia, C; Casanova, MJ; Huelin, P; Calvo, M; Tosca, J; Fernandez-Salazar, L; Arajol, C; Zabana, Y; Bastida, G; Hinojosa, J; Marquez, L; Barreiro-De-Acosta, M; Calvet, X; Monfort, D; Gomez-Garcia, MR; Rodriguez, E; Huguet, JM; Rojas-Feria, M; Hervias, D; Atienza, R; Busquets, D; Zapata, E; Duenas, C; Charro, M; Martinez-Cerezo, FJ; Plaza, R; Vazquez, JM; Gisbert, JP; Canete, F; Cabre, E; Domenech, E

Phenotype and natural history of elderly onset inflammatory bowel disease: a multicenter, case-control study

ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 2018;

FI: 7,357; D1

Martinez-Lopez, A; Blasco-Morente, G; Perez-Lopez, I; Tercedor-Sanchez, J; Arias-Santiago, S.

Studying the effect of systemic and biological drugs on intima-media thickness in patients suffering from moderate and severe psoriasis.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY, 2018;

FI: 4,287; Q1

Casanova, MJ; Chaparro, M; Garcia-Sanchez, V; Nantes, O; Leo, E; Rojas-Feria, M; Jauregui-Amezaga, A; Garcia-Lopez, S; Huguet, JM; Arguelles-Arias, F; Aicart, M; Marin-Jimenez, I; Gomez-Garcia, M; Munoz, F; Esteve, M; Bujanda, L; Cortes, X; Tosca, J; Pineda, JR; Mannose, M; Llao, J; Guardiola, J; Perez-Martinez, I; Munoz, C; Gonzalez-Lama, Y; Hinojosa, J; Vazquez, JM; Martinez-Montiel, MP; Rodriguez, GE; Pajares, R; Garcia-Sepulcre, MF; Hernandez-Martinez, A; Perez-Calle, JL; Beltran, B; Busquets, D; Ramos, L; Bermejo, F; Barrio, J; Barreiro-de Acosta, M; Roncedo, O; Calvet, X; Hervias, D; Gomollon, F; Dominguez-Antonaya, M; Alcain, G; Sicilia, B; Duenas, C; Gutierrez, A; Lorente-Poyatos, R; Dominguez, M; Khorrami, S; Munoz, C; Taxonera, C; Rodriguez-Perez, A; Ponferrada, A; Van Domselaar, M; Arias-Rivera, ML; Merino, O; Castro, E; Marrero, JM; Martin-Arranz, M; Bottle, B; Fernandez-Salazar, L; Monfort, D; Opium, V; Garcia-Herola, A; Menacho, M; Ramirez-de La Piscina, P; Ceballos, D; Almela, P; Navarro-Llavat, M; Robles-Alonso, V; Vega-Lopez, AB; Moraleja, I; Novella, MT; Castano-Milla, C; Sanchez-Torres, A; Benitez, JM; Rodriguez, C; Castro, L; Garrido, E; Domenech, E; Garcia-Planella, E; Gisbert, JP

Evolution After Anti-TNF Discontinuation in Patients With Inflammatory Bowel Disease: A Multicenter Long-Term Follow-Up Study

AMERICAN JOURNAL OF GASTROENTEROLOGY, 2017;

FI: 9,566; D1

Martinez-Lopez, A; Blasco-Morente, G; Perez-Lopez, I; Herrera-Garcia, JD; Luque-Valenzuela, M; Sanchez-Cano, D; Lopez-Gutierrez, JC; Ruiz-Villaverde, R; Tercedor-Sanchez, J.

CLOVES syndrome: review of a PIK3CA-related overgrowth spectrum (PROS)

CLINICAL GENETICS, 2017;

FI: 3,326; Q2

Ruiz-Villaverde, R; Bueno-Rodriguez, A; Tercedor-Sanchez, J.

Apremilast, beyond psoriasis as a therapeutic target

CLINICAL MEDICINE, 2017;

FI: 1,125; Q3

Perez-Lopez, I; Martinez-Lopez, A; Blasco-Morente, G; Ruiz-Villaverde, R; Tercedor-Sanchez, J.

Is it safe to use N-acetylcysteine in the treatment of bilateral ectropion on collodion baby?

INTERNATIONAL JOURNAL OF DERMATOLOGY, 2017;

FI: 1,56; Q3

Martinez-Lopez, A; Blasco-Morente, G; Perez-Lopez, I; Naranjo-Diaz, MJ; Aneiros-Fernandez, J; Ruiz-Villaverde, R; Tercedor-Sanchez, J.

Successful Treatment of Proliferative Verrucous Leukoplakia With 5% Topical Imiquimod

DERMATOLOGICAL THERAPY, 2017;

FI: 1,093; Q4

Taxonera, C; Barreiro-de-Acosta, M; Bastida, G; Martinez-Gonzalez, J; Merino, O; Garcia-Sanchez, V; Gisbert, J.P.; Marin-Jimenez, I; Lopez-Serrano, P; Gomez-Garcia, M; Iglesias, E; Lopez-Sanroman, A; Chaparro, M; Sara, C; Bermejo, F; Perez-Carazo, L; Square, R; Olivares, D; Dawn, C; Mendoza, JL; Fernandez-Blanco, I

Outcomes of Medical and Surgical Therapy for Entero-urinary Fistulas in Crohn's Disease

JOURNAL OF CROHNS & COLITIS, 2016;

FI: 6,585; D1

Stephens, C; Moreno-Casares, A; Lopez-Nevot, MA; Garcia-Cortes, M; Medina-Caliz, I; Hallal, H; Soriano, G.; Roman, E.; Ruiz-Cabello, F; Romero-Gomez, M; Lucena, MI; Andrade, RJ

Killer Immunoglobulin-Like Receptor Profiles Are Not Associated with Risk of Amoxicillin-Clavulanate-Induced Liver Injury in Spanish Patients

FRONTIERS IN PHARMACOLOGY, 2016;

FI: 4,418; Q1

Lupianez, CB; Canet, LM; Carvalho, A; Alcazar-Fuoli, L; Springer, J; Lackner, M; Segura-Catena, J; Cumin, A; Olmedo, C; Rios, R; Fernandez-Montoya, A; Cuenca-Estrella, M; Solano, C; Lopez-Nevot, MA; Cunha, C; Oliveira-Coelho, A; Villaescusa, T; Fianchi, L; Aguado, JM; Pagano, L; Lopez-Fernandez, E; Potenza, L; Luppi, M; Lass-Florl, C; Loeffler, J; Einsele, H; Vazquez, L; Jurado, M; Sainz, J

Polymorphisms in Host Immunity-Modulating Genes and Risk of Invasive Aspergillosis: Results from the AspBIOmics Consortium

INFECTION AND IMMUNITY, 2016;

FI: 3,603; Q1

Encarnacion, MC; Palomino-Morales, RJ; Fuchs, JE; Hope, PG; Noel, MT; Exited, E; Timson, DJ; Pey, AL

Conformational dynamics is key to understanding loss-of-function of NQO1 cancer-associated polymorphisms and its correction by pharmacological ligands

SCIENTIFIC REPORTS, 2016;

FI: 5,228; Q1

Martinez-Chamorro, A; Moreno, A; Gomez-Garcia, M; Hair, MJ; Martin, J; Lopez-Nevot, MA

MICA * A4 protects against ulcerative colitis, whereas MICA * A5.1 is associated with abscess formation and age of onset

CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2016;

FI: 3,148; Q2

Ramos, JL; Cuenca, MS; Molina-Santiago, C; Segura, A; Duke, E; Gomez-Garcia, MR; Udaondo, Z; Rock, A

Mechanisms of solvent resistance mediated by interplay of cellular factors in Pseudomonas putida

FEMS MICROBIOLOGY REVIEWS, 2015;

FI: 13,244; D1

Canet, LM; Chalice, R; Lupianez, C.B.; Canhao, H; Martinez, M; Squire, A; Filipescu, I; Segura-Catena, J; Soto-Pino, MJ; Ferrer, MA; Garcia, A; Romany, L; Perez-Pampin, E; Gonzalez-Utrilla, A; Lopez Nevot, MA; Collantes, E; Fonseca, J.E.; Sainz, J.

Genetic variants within immune-modulating genes influence the risk of developing rheumatoid arthritis and anti-TNF drug response: a two-stage case-control study

PHARMACOGENETICS AND GENOMICS, 2015;

FI: 3,481; Q1

Canet, LM; Filipescu, I; Chalice, R; Lupianez, C.B.; Canhao, H; Squire, A; Segura-Catena, J; Soto-Pino, MJ; Ferrer, MA; Garcia, A; Romany, L; Perez-Pampin, E; Gonzalez-Utrilla, A; Nevoth, MAL; Collantes, E; Fonseca, J.E.; Sainz, J.

Genetic variants within the TNFRSF1B gene and susceptibility to rheumatoid arthritis and response to anti-TNF drugs: a multicenter study

PHARMACOGENETICS AND GENOMICS, 2015;

FI: 3,481; Q1

Moreno-Rincon, E; Benitez, JM; Serrano-Ruiz, FJ; Vazquez-Moron, JM; Pallares-Manrique, H; Herrera-Justiniano, JM; Leo-Carnerero, E; Gomez-Garcia, M.R.; Cabello-Tapia, MJ; Castro-Fernandez, M; Rojas-Fair, M; Castro-Laria, L; Arguelles-Arias, F; Camargo-Camero, R; Alcain-Martinez, G; Iglesias-Flores, E; Garcia-Sanchez, V

Prognosis of Patients with Ulcerative Colitis in Sustained Remission After Thiopurines Withdrawal

INFLAMMATORY BOWEL DISEASES, 2015;

FI: 4,464; Q1

Ortiz-Fernandez, L; Garcia-Lozano, JR; Montes-Cano, MA; Conde-Jaldon, M; Leo, E; Ortego-Centeno, N; Gomez-Garcia, M; Garcia-Hernandez, FJ; Marquez, JL; Espinosa, G; Grana-Gil, G; Sanchez-Burson, J; Julia, MR; White, R; Barnosi-Marin, AC; Solans, R; Fanlo, P; Rodriguez-Carballeira, M; Camps, T; Castaneda, S; Martin, J; Gonzalez-Escribano, MF