MP03-Internal Medicine - HVN investigates

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Research group focused on the study of patients with high vascular risk and/or systemic autoimmune diseases.

Research lines

A.- LINES RELATED TO VASCULAR RISK
1.- Preventive and therapeutic effects of physical exercise in patients with vascular risk:
1.1.- Effects of EF in patients with Familial Hypercholesterolemia (FH).
1.2.- Effects of EF in patients with Systemic Lupus Erythematosus.
2.- Detection of subclinical cardiovascular disease and stratification of vascular risk in patients with Familial Hypercholesterolemia.
3.- Refractory hypertension and renal denervation.
B.- LINES RELATED TO SYSTEMIC AUTOIMMUNE DISEASES
1.- Population characterization of Systemic Lupus Erythematosus and Sjögren's Syndrome.
2.- Undetermined connective tissue disease.
3.- Immune-mediated ocular inflammation and systemic autoimmune diseases.
4.- Immune-mediated disease of the inner ear and systemic autoimmune diseases.

FERNANDO JAEN AGUILA

BLANCA GAVILAN CARRERA

JUAN DIEGO MEDIAVILLA GARCIA

NURIA NAVARRETE NAVARRETE

JOSE MARIO SABIO SANCHEZ

ORCID

JOSE ANTONIO VARGAS MILESTONES

MONICA ZAMORA PAST

ANTONIO DIAZ CHAMORRO

Montero-Lopez, E; Peralta-Ramirez, M; Ortego-Centeno, N; Sabio, JM; Callejas-Rubio, JL; Navarrete-Navarrete, N; Garcia-Rios, M; Santos-Ruiz, A

Does stress response axis activation differ between patients with autoimmune disease and healthy people?

STRESS AND HEALTH, 2024;

FI: 3,1; Q1

Llorente-Romero, S; Herrador-Colmenero, M; Acosta-Manzano, P; Borges-Cosic, M; Gavilán-Carrera, B; Roman, PAL; Delgado-Fernández, M; Segura-Jiménez, V

Association of Moderate-to-Vigorous Physical Activity, Sedentary Time, Fat Percentage, and Physical Fitness with Gait Parameters in Women with Fibromyalgia: The Al-Ándalus Project

BIOMEDICINE, 2024;

FI: 3,9; Q1

Araujo-Castro, M; Fano, MP; González-Boillos, M; Pascual-Corrales, E; Rojas-Marcos, PM; García-Cano, A; Ruiz-Sanchez, JG; Vincent, A; Gómez-Hoyos, E; Casteras, A; Puig-Perez, A; Sanz, IG; Recasens, M; San Millan, RB; Caesar, MJ; Guardiola, PD; Perdomo, CM; Manjón-Miguélez, L; Roman, AR; Lazaro, CR; Recio, JM; Morales-Ruiz, M; Calatayud, M; Lopez, NJ; Meneses, D; Nuñez, MS; Ribas, EM; Sánchez, AS; Diaz, CG; Lamas, C; Tous, MD; Serrano, J; Michalopoulou, T; Rodrigo, ST; Chamorro, RR; Aguila, FJ; Mateo, EMM; Gutiérrez-Medina, S; Hanzu, F.A.; Ramirez, PP

Impact of primary aldosteronism on kidney function: results from the SPAIN-ALDO registry

JOURNAL OF HYPERTENSION, 2024;

FI: 3,3; Q1

Gavilan-Carrera, Blanca; Martinez-Rosales, Elena; Palacios-Morenilla, Clara; Diaz-Chamorro, Antonio; Soriano-Maldonado, Alberto; Vargas-Hitos, Jose Antonio

Associations of physical activity, sedentary time, and fitness with cardiovascular risk and atherosclerosis over 3 years in women with systemic lupus erythematosus

CLINICAL MEDICINE, 2024;

FI: 2,6; Q1

Gavilán-Carrera, B; Aguilera-Fernández, V; Amaro-Gahete, FJ; Rosales-Castillo, A; Soriano-Maldonado, A; Vargas-Hitos, J.A.

Association of the Mediterranean diet with arterial stiffness, inflammation, and medication use in women with systemic lupus erythematosus: An exploratory study

JOURNAL OF NUTRITIONAL BIOCHEMISTRY, 2024;

FI: 4,8; Q1

Gavilan-Carrera, B; Soriano-Maldonado, A; Mediavilla-Garcia, JD; Lavie, CJ; Vargas-Hitos, JA

Prescribing statin therapy in physically (in)active individuals vs prescribing physical activity in statin-treated patients: A four-scenario practical approach

PHARMACOLOGICAL RESEARCH, 2023;

FI: 9,3; D1

Gavilan-Carrera, B; Ruiz-Cobo, A; Amaro-Gahete, FJ; Soriano-Maldonado, A; Vargas-Hitos, JA

No Changes in Body Composition and Adherence to the Mediterranean Diet after a 12-Week Aerobic Training Intervention in Women with Systemic Lupus Erythematosus: The EJERCITA-LES Study

NUTRIENTS, 2023;

FI: 5,9; Q1

Bustos-Merlo, A; Rosales-Castillo, A; Navarrete-Navarrete, N

Panuveitis caused by Listeria monocytogenes

CLINICAL MEDICINE, 2023;

FI: 3,9; Q2

Sabio, JM; Garcia-de los Rios, C; Medina-Casado, M; Del Aguila-Garcia, MD; Calix-Calix, R; Diaz-Chamorro, A

High-sensitivity cardiac troponin I is a biomarker for increased arterial stiffness in systemic lupus erythematous women with normal kidney function

RHEUMATOLOGY INTERNATIONAL, 2023;

FI: 4; Q2

Rosales-Castillo, A; Wise, J.M.

Prevalence and characteristics of systemic autoimmune diseases-related autoantibodies in convalescent patients after SARS-CoV-2 infection

CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, 2023;

FI: 3,7; Q3

Carbonell, C; Marcos, M; Guillen-Del-Castillo, A; Rubio-Rivas, M; Argibay, A; Marin-Ballve, A; Rodriguez-Pinto, I; Balda-Masmiquel, M; Callejas-Moraga, E; Colunga, D; Saez-Comet, L; Gonzalez-Echavarri, C; Ortego-Centeno, N; Mari-Alfonso, B; Vargas-Hitos, JA; Todoli-Parra, JA; Trapiella, L; Herranz-Marin, MT; Freire, M; Castro-Salomo, A; Perales-Fraile, I; Madronero-Vuelta, AB; Sanchez-Garcia, ME; Ruiz-Munoz, M; Gonzalez-Garcia, A; Sanchez-Redondo, J; De-la-Red-Bellvis, G; Fernandez-Luque, A; Muela-Molinero, A; Lledo, GM; Tolosa-Vilella, C; Fonollosa-Pla, V; Chamorro, AJ; Simeon-Aznar, CP

Standardized incidence ratios and risk factors for cancer in patients with systemic sclerosis: Data from the Spanish Scleroderma Registry (RESCLE).

AUTOIMMUNITY REVIEWS, 2022;

FI: 17,39; D1

Sage, JM

Withdrawal of low-dose prednisone in inactive SLE patients: Is there another alternative?

ANNALS OF THE RHEUMATIC DISEASES, 2022;

FI: 27,973; D1

Rosales-Castillo, A; Wise, J.M.

Assessment of antiphospholipid antibodies during the follow-up of patients after SARS-CoV-2 infection

CLINICAL MEDICINE, 2022;

FI: 3,2; Q2

Gavilan-Carrera, B; Vargas-Hitos, JA; Morillas-de-Laguno, P; Rosales-Castillo, A; Sola-Rodriguez, S; Callejas-Rubio, JL; Wise, JM; Soriano-Maldonado, A

Effects of 12-week aerobic exercise on patient-reported outcomes in women with systemic lupus erythematosus

DISABILITY AND REHABILITATION, 2022;

FI: 2,439; Q2

Garcia, AG; Fabregate, M; Manzano, L; del Castillo, AG; Rivas, MR; Argibay, A; Ballve, AM; Pinto, IR; Chambers, XP; Mari-Alfonso, B; Moraga, EC; Arguelles, DC; Comet, L.S.; Gonzalez-Echavarri, C; Ortego-Centeno, N; Milestones, JAV; Parra, JAT; Martinez, L.T. Marin, MTH; Freire, M; Chamorro, AJ; Friar, IP; Return, ABM; Wheat, SS; Vilella, CT; Pla, VF; Aznar, CPS

Left ventricular diastolic dysfunction in systemic sclerosis: Clinical, immunological and survival differences in the Spanish RESCLE registry.

SEMINARS IN ARTHRITIS AND RHEUMATISM, 2022;

FI: 5,431; Q2

Jimenez, AC; Navarrete, NN; Gomez, AGR; Lopez, F.F.; Rodriguez, RG; Torrijos, E.G.

First case of DRESS syndrome caused by hydroxychloroquine with a positive patch test

CONTACT DERMATITIS, 2021;

FI: 6,6; D1

Roa-Chamorro, R; Jaen-Aguila, F; Door-Door, JM; Torres-Quintero, L; González-Bustos, P; Mediavilla-Garcia, J.D.

Arterial hypertension assessment in a population with chronic myeloid leukemia

SCIENTIFIC REPORTS, 2021;

FI: 4,38; Q1

Hernandez-Martinez, A; Gavilan-Carrera, B; Vargas-Hitos, JA; Morillas-de-Laguno, P; Sola-Rodriguez, S; Rosales-Castillo, A; Artero, E.G.; Wise, J.M.; Soriano-Maldonado, A.

Ideal cardiovascular health in women with systemic lupus erythematosus: Association with arterial stiffness, inflammation, and fitness

INTERNATIONAL JOURNAL OF CARDIOLOGY, 2021;

FI: 4,164; Q2

Jiménez-Alonso, J; Navarrete-Navarrete, N; Jimenez-Jaimez, E; Jaimez, L.

Myasthenia gravis and systemic lupus erythematosus: Presentation of 5 cases and PubMed review

NEUROLOGY, 2021;

FI: 3,109; Q3

Antonio, R. C.; de los Rios, CG; Garcia, J.D.M.

Persistent symptoms after acute COVID-19 infection: importance of follow-up

CLINICAL MEDICINE, 2021;

FI: 1,725; Q3

Martinez-Rosales, E; Sola-Rodriguez, S; Vargas-Hitos, JA; Gavilan-Carrera, B; Rosales-Castillo, A; Hernandez-Martinez, A; Artero, EG; Sage, JM; Soriano-Maldonado, A

Heart Rate Variability in Women with Systemic Lupus Erythematosus: Association with Health-Related Parameters and Effects of Aerobic Exercise.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, 2020;

Gavilan-Carrera, B; Vargas-Hitos, JA; Soriano-Maldonado, A.

Comment on: Physical activity, sedentary behavior and their associations with cardiovascular risk in systemic lupus erythematosus

RHEUMATOLOGY, 2020;

FI: 5,606; Q1

Alvarez-Cienfuegos, A; Cantero-Nieto, L; Garcia-Gomez, JA; Sage, JM; Gonzalez-Gay, MA; Ortego-Centeno, N

Association between homocysteine levels and arterial stiffness in women with systemic sclerosis

CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, 2020;

FI: 3,319; Q2

Pestana-Fernandez, M; Rubio-Rivas, M; Tolosa-Vilella, C; Guillen-Del-Castillo, A; Freire, M; Vargas-Hitos, JA; Todoli-Parra, J.A.; Rodriguez-Carballeira, M; Marin-Balv, A; Espinosa, G; Colunga-Arguelles, D; Ortego-Centeno, N; Trapiella-Martinez, L; carbon

Longterm Efficacy and Safety of Monotherapy versus Combination Therapy in Systemic Sclerosis-associated Pulmonary Arterial Hypertension: A Retrospective RESCLE Registry Study.

JOURNAL OF RHEUMATOLOGY, 2020;

FI: 3,35; Q2

Soriano-Maldonado, A; Martinez-Forte, S; Ferrer-Marquez, M; Martinez-Rosales, E; Hernandez-Martinez, A; Carter-Ruiz, A; Villa-Gonzalez, E; Barranco-Ruiz, Y; Rodriguez-Perez, MA; Torrente-Sanchez, MJ; Carmona-Rodriguez, L; Soriano-Maldonado, P; Vargas-H

Physical Exercise following bariatric surgery in women with Morbid obesity Study protocol clinical trial (SPIRIT compliant)

MEDICINE, 2020;

FI: 1,552; Q3

Lopez-Isac, E; Acosta-Herrera, M; Kerick, M; Assassi, S; Satpathy, AT; Farm, J; Mumbach, MR; Beretta, L; Simeon, CP; Carreira, P; Ortego-Centeno, N; Castellvi, I; Bossini-Castillo, L; Carmona, FD; Orozco, G; Hunzelmann, N; Distler, JHW; Franke, A; Lunardi, C; Moroncini, G; Gabrielli, A; de Vries-Bouwstra, J; Wijmenga, C; Koeleman, BPC; Nordin, A; Padyukov, L; Hoffmann-Vold, AM; Lie, B; Rios, R; Callejas, JL; Vargas-Hitos, JA; Garcia-Portales, R; Camps, MT; Fernandez-Nebro, A; Gonzalez-Escribano, MF; Garcia-Hernandez, FJ; Castillo, MJ; Aguirre, MA; Gomez-Gracia, I; Fernandez-Gutierrez, B; Rodriguez-Rodriguez, L; de la Pena, PG; Vicente, E; Andreu, JL; de Castro, MF; Lopez-Longo, FJ; Martinez, L; Fonollosa, V; Guillen, A; Espinosa, G; Tolosa, C; Pros, A; Rodriguez-Carballeira, M; Narvaez, FJ; Rubio-Rivas, M; Ortiz-Santamaria, V; Madronero, AB; Gonzalez-Gay, MA; Diaz, B; Trapiella, L; Sousa, A; Egurbide, MV; Fanlo-Mateo, P; Saez-Comet, L; Diaz, F; Hernandez, V; Beltran, E; Roman-Ivorra, JA; Grau, E; Alegre-Sancho, JJ; Freire, M; Blanco-Garcia, FJ; Oreiro, N; Witte, T; Kreuter, A; Riemekasten, G; Airo, P; Lean, C; Voskuyl, AE; Vonk, MC; Hesselstrand, R; Proudman, S; Stevens, W; Nikpour, M; Zochling, J; Sahhar, J; Roddy, J; Nash, P; Tymms, K; Rischmueller, M; Lester, S; Vyse, T; Herrick, AL; Worthington, J; Denton, CP; Allanore, Y; Brown, MA; Radstake, TRDJ; Fonseca, C; Chang, HY; Mayes, MD; Martin, J

GWAS for systemic sclerosis identifies multiple risk loci and highlights fibrotic and vasculopathy pathways

NATURE COMMUNICATIONS, 2019;

FI: 11,878; D1

Gavilan-Carrera, B; da Silva, JG; Vargas-Hitos, JA; Sage, JM; Morillas-de-Laguno, P; Rios-Fernandez, R; Delgado-Fernandez, M; Soriano-Maldonado, A

Association of physical fitness components and health-related quality of life in women with systemic lupus erythematosus with mild disease activity.

PLOSONE, 2019;

FI: 2,776; Q2

Badiola, J; Navarrete-Navarrete, N; Sage, JM

Thrombotic microangiopathy in a patient with eosinophilic granulomatosis with polyangiitis: case-based review

RHEUMATOLOGY INTERNATIONAL, 2019;

FI: 2,2; Q3

Sage, JM; De Betolaza, S; Vargas-Hitos, JA

Characteristics and safety of tattoos in patients with systemic lupus erythematosus

LUPUS, 2019;

FI: 2,924; Q3

Garcia-Hernandez, FJ; Castillo-Palma, MJ; Tolosa-Vilella, C; Guillen-del Castillo, A; Rubio-Rivas, M; Freire, M; Vargas-Hitos, JA; Todoli-Parra, J.A.; Rodriguez-Carballeira, M; Espinosa-Garriga, G; Colunga-Arguelles, D; Ortego-Centeno, N; Trapiella-Martinez, L; Rodero-Roldán, MM; Pla-Salas, X; Perales-Fraile, I; del Campo, IPM; Chamorro, A. J.; Giménez, R.A.F.D.; Madronero-Vuelta, AB; Ruiz-Munoz, M; Fonollosa-Pla, V; Simeon-Aznar, CP

Pulmonary hypertension in Spanish patients with systemic sclerosis. Data from the RESCLE registry

CLINICAL RHEUMATOLOGY, 2019;

FI: 2,293; Q3

Soriano-Maldonado, A; Morillas-de-Laguno, P; Sage, JM; Gavilan-Carrera, B; Rosales-Castillo, A; Montalban-Mendez, C; Saez-Uran, LM; Callejas-Rubio, JL; Vargas-Hitos, JA

Effects of 12-week Aerobic Exercise on Arterial Stiffness, Inflammation, and Cardiorespiratory Fitness in Women with Systemic LUPUS Erythematosus: Non-Randomized Controlled Trial

JOURNAL OF CLINICAL MEDICINE, 2018;

FI: 5,583; D1

Garcia-Silva, J; Navarrete, NN; Peralta-Ramirez, MI; Garcia-Sanchez, A; Ferrer-Gonzalez, MA; Horse, VE

Efficacy of Cognitive Behavioral Therapy in Adherence to the Mediterranean Diet in Metabolic Syndrome Patients: A Randomized Controlled Trial

JOURNAL OF NUTRITION EDUCATION AND BEHAVIOR, 2018;

FI: 2,571; Q1

Mari-Alfonso, B; Simeon-Aznar, CP; Guillen-Del Castillo, A; Rubio-Rivas, M; Trapiella-Martinez, L; Todoli-Parra, JA; Carballeira, MR; Marin-Ballve, A; Iniesta-Arandia, N; Colunga-Arguelles, D; Castillo-Palma, MJ; Saez-Comet, L; Egurbide-Arberas, MV; Ortego-Centeno, N; Freire, M; Milestones, JAV; Chamorro, AJ; Madronero-Vuelta, AB; Perales-Fraile, I; Pla-Salas, X; Fernandez-De-La-Puebla, RA; Fonollosa-Pla, V; Tolosa-Vilella, C

Hepatobiliary involvement in systemic sclerosis and the cutaneous subsets: Characteristics and survival of patients from the Spanish RESCLE Registry

SEMINARS IN ARTHRITIS AND RHEUMATISM, 2018;

FI: 4,356; Q1

Montalban-Mendez, C; Soriano-Maldonado, A; Vargas-Hitos, JA; Saez-Uran, LM; Rosales-Castillo, A; Morillas-de-Laguno, P; Gavilan-Carrera, B; Jimenez-Alonso, J.

Cardiorespiratory fitness and age-related arterial stiffness in women with systemic lupus erythematosus.

EUROPEAN JOURNAL OF CLINICAL RESEARCH, 2018;

FI: 3,086; Q1

Morillas-de-Laguno, P; Vargas-Hitos, JA; Rosales-Castillo, A; Siez-Uran, LM; Montalban-Mendez, C; Gavilan-Carrera, B; Navarro-Mateos, C; Acosta-Manzano, P; Delgado-Fernandez, M; Sage, JM; Ortego-Centeno, N; Callejas-Rubio, JL; Soriano-Maldonado, A

Association of objectively measured physical activity and sedentary time with arterial stiffness in women with systemic lupus erythematosus with mild disease activity.

PLOSONE, 2018;

FI: 2,766; Q1

Sage, JM

Systemic inflammation and endothelial dysfunction-a possible link between osteoarthritis and hypertension: comment on the article by Niu et al

ARTHRITIS & RHEUMATOLOGY, 2017;

FI: 6,918; D1

Langefeld, CD; Ainsworth, HC; Graham, DSC; Kelly, JA; Comeau, ME; Marion, MC; Howard, TD; Ramos, PS; Croker, JA; Morris, DL; Sandling, JK; Almlof, JC; Acevedo-Vasquez, EM; Alarcon, GS; Babini, AM; Baca, V; Bengtsson, AA; Berbotto, GA; Bijl, M; Brown, EE; Brunner, HI; Cardiel, MH; Catoggio, L; Cervera, R; Cucho-Venegas, JM; Dahlqvist, SR; D'Alfonso, S; Silva, BM; Figueroa, ID; Doria, A; Edberg, JC; Endreffy, E; Esquivel-Valerio, JA; Fortin, PR; Freedman, BI; Frostegard, J; Garcia, MA; de la Torre, IG; Gilkeson, GS; Gladman, DD; Gunnarsson, I; Guthridge, JM; Huggins, JL; James, JA; Kallenberg, CGM; Kamen, DL; Karp, DR; Kaufman, KM; Kottyan, LC; Kovacs, L; Laustrup, H; Lauwerys, BR; Li, QZ; Maradiaga-Cecena, MA; Martin, J; McCune, JM; McWilliams, DR; Merrill, JT; Miranda, P; Moctezuma, JF; Nath, SK; Niewold, TB; Orozco, L; Ortego-Centeno, N; Petri, M; Pineau, CA; Pons-Estel, BA; Pope, J; Raj, P; Ramsey-Goldman, R; Reveille, JD; Russell, LP; Sage, JM; Aguilar-Salinas, CA; Scherbarth, HR; Scorza, R; Seldin, MF; Sjowall, C; Svenungsson, E; Thompson, SD; Toloza, SMA; Truedsson, L; Tusie-Luna, T; Vasconcelos, C; Vila, LM; Wallace, DJ; Weisman, MH; Wither, JE; Bhangale, T; Oksenberg, JR; Rioux, JD; Gregersen, PK; Syvanen, AC; Ronnblom, L; Criswell, LA; Jacob, CO; Sivils, KL; Tsao, BP; Schanberg, LE; Behrens, TW; Silverman, ED; Alarcon-Riquelme, ME; Kimberly, RP; Harley, JB; Wakeland, EK; Graham, RR; Gaffney, PM; Vyse, TJ

Transancestral mapping and genetic load in systemic lupus erythematosus

NATURE COMMUNICATIONS, 2017;

FI: 12,124; D1

Marquez, A; Vidal-Bralo, L; Rodriguez-Rodriguez, L; Gonzalez-Gay, MA; Balsa, A; Gonzalez-Alvaro, I; Carreira, P; Ortego-Centeno, N; Ayala-Gutierrez, MM; Garcia-Hernandez, FJ; Gonzalez-Escribano, MF; Sage, JM; Tolosa, C; Suarez, A; Gonzalez, A; Padyukov, L; Worthington, J; Vyse, T; Alarcon-Riquelme, ME; Martin, J

A combined large-scale meta-analysis identifies COG6 as a novel shared risk locus for rheumatoid arthritis and systemic lupus erythernatosus

ANNALS OF THE RHEUMATIC DISEASES, 2017;

FI: 12,811; D1

Soriano-Maldonado, A; Vargas-Hitos, JA; Jimenez-Jaimez, J.

Exercise for Patients With Hypertrophic Cardiomyopathy

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2017;

FI: 44,405; D1

Trapiella-Martinez, L; Diaz-Lopez, JB; Caminal-Montero, L; Tolosa-Vilella, C; Castle, AGD; Colunga-Arguelles, D; Rubio-Rivas, M; Iniesta-Arandia, N; Castillo-Palma, MJ; Saez-Comet, L; Egurbide-Arberas, M.V.; Ortego-Centeno, N; Freire, M; Vargas-Hitos, JA; Rios-Blanco, JJ; Todoli-Parra, J.A.; Rodriguez-Carballeira, M; Marin-Ballve, A; Chamorro-Fernandez, AJ; Pla-Salas, X; Madronero-Vuelta, AB; Ruiz-Munoz, M; Fonollosa-Pla, V; Simeon-Aznar, CP

Very early and early systemic sclerosis in the Spanish scleroderma Registry (RESCLE) cohort

AUTOIMMUNITY REVIEWS, 2017;

FI: 8,961; D1

Vargas-Hitos, JA; Sage, JM; Navarrete-Navarrete, N; Zamora-Pasadas, M; Jimenez-Alonso, J

Severe digital necrosis as the clinical onset of antiphospholipid syndrome

INTERNAL AND EMERGENCY MEDICINE, 2016;

FI: 2,34; Q1

Rivera-Lopez, R; Jimenez-Jaimez, J; Sage, JM; Zamora-Pasadas, M; Vargas-Hitos, JA; Martinez-Bordonado, J; Navarrete-Navarrete, N; Fernandez, RR; Sanchez-Cantalejo, E; Jimenez-Alonso, J

Relationship between QT Interval Length and Arterial Stiffness in Systemic Lupus Erythematosus (SLE): A Cross-Sectional Case-Control Study

PLOSONE, 2016;

FI: 3,057; Q1

Vargas-Hitos, JA; Roa-Chamorro, R; Sage, JM; Javier-Martinez, R; Martin-Castro, A; Jimenez-Alonso, J

Leishmaniasis, lupus nephritis and immunosuppressive therapy

QJM-AN INTERNATIONAL JOURNAL OF MEDICINE, 2016;

FI: 2,824; Q1

Sage, JM

Systemic lupus erythematosus today

CLINICAL MEDICINE, 2016;

FI: 1,267; Q2

Sage, JM; Vargas-Hitos, JA; Martinez-Bordonado, J; Navarrete-Navarrete, N; Diaz-Chamorro, A; Olvera-Porcel, C; Jimenez-Alonso, J

Cumulated organ damage is associated with arterial stiffness in women with systemic lupus erythematosus irrespective of renal function

CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, 2016;

FI: 2,495; Q2

Simeon-Aznar, C.P.; Fonollosa-Pla, V; Tolosa-Vilella, C; Espinosa-Garriga, G; Campillo-Grau, M; Ramos-Casals, M; Garcia-Hernandez, FJ; Castillo-Palma, MJ; Sanchez-Roman, J; Callejas-Rubio, JL; Ortego-Centeno, N; Egurbide-Arberas, M.V.; Trapiellla-Martinez, L; Caminal-Montero, L; Saez-Comet, L; Velilla-Marco, J; Camps-Garcia, MT; de Ramon-Garrido, E; Esteban-Marcos, EM; Pallares-Ferreres, L; Navarrete-Navarrete, N; Vargas-Hitos, JA; de la Torre, RG; Salvador-Cervello, G; Rios-Blanco, JJ; Vilardell-Tarres, M.

Registry of the Spanish Network for Systemic Sclerosis Survival, Prognostic Factors, and Causes of Death

MEDICINE, 2015;

FI: 5,723; D1

Sage, JM; Sanchez-Berna, I; Martinez-Bordonado, J; Vargas-Hitos, JA; Navarrete-Navarrete, N; Ruiz, ME; Jimenez-Alonso, J

Prevalence of and Factors Associated With Increased Arterial Stiffness in Patients With Primary Sjogren's Syndrome

ARTHRITIS CARE & RESEARCH, 2015;

FI: 4,713; Q1

Sage, JM; Vargas-Hitos, JA; Martinez-Bordonado, J; Navarrete-Navarrete, N; Jimenez-Alonso, J

Effect of mycophenolate mofetil on active hepatitis C virus in a woman with lupus nephritis after two years of follow-up

CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, 2015;

FI: 2,724; Q2

Sanchez-Berna, I; Santiago-Diaz, C; Jimenez-Alonso, J.

Immunomodulatory properties of stem mesenchymal cells in autoimmune diseases

CLINICAL MEDICINE, 2015;

FI: 1,417; Q2

Sage, JM; Martinez-Bordonado, J; Sanchez-Berna, I; Vargas-Hitos, JA; Mediavilla, JD; Navarrete-Navarrete, N; Zamora-Pasadas, M; Ruiz, ME; Jimenez-Alonso, J

Nighttime Blood Pressure Patterns and Subclinical Atherosclerosis in Women with Systemic Lupus Erythematosus

JOURNAL OF RHEUMATOLOGY, 2015;

FI: 3,187; Q2

UPPA-FH – Deciphering the impact of physical exercise on cardiorespiratory fitness, atherosclerosis and underlying mechanisms in patients with familial hypercholesterolemia

Funder: STATE RESEARCH AGENCY - PRTR

File number: PID2022-142844OB-I00

Execution time: 01/09/2023 - 31/08/2025

IP: JOSE ANTONIO VARGAS MILESTONES

Effects of a Physical Exercise Program on Subclinical Arteriosclerosis and Inflammation of Patients With Systemic Lupus Erythematosus

Funder: COUNCIL OF HEALTH

File number: PI-0525-2016

Execution time: 01/01/2017 - 31/12/2017

IP: JOSE ANTONIO VARGAS MILESTONES

Open-label extension study to evaluate the long-term safety, efficacy, and tolerability of Lorundrostat in subjects with hypertension

Financier: ACCOVION GMBH

Type of test: CLINICAL TRIAL WITH DRUGS

Execution time: 18/09/2024 - 23/08/2025

IP: FERNANDO JAEN AGUILA

A phase 3, randomized, double-blind, placebo-controlled study to investigate the effect of lepodisiran on the reduction of serious adverse cardiovascular events in adults with elevated lipoprotein(a) and confirmed atherosclerotic cardiovascular disease or increased risk of a first cardiovascular event – ACCLAIM-Lp(a)

Financier: LILLY, SA

Type of test: CLINICAL TRIAL WITH DRUGS

Execution time: 23/02/2024 - 30/05/2028

IP: PABLO GONZALEZ BUSTOS

A phase 3, multicenter, randomized, double-blind, placebo-controlled, parallel-group study to evaluate the efficacy and safety of lorundrostat in subjects with uncontrolled and resistant hypertension.

Financier: ACCOVION GMBH

Type of test: CLINICAL TRIAL WITH DRUGS

Execution time: 23/02/2024 - 23/06/2025

IP: FERNANDO JAEN AGUILA

A randomized, double-blind, placebo-controlled, parallel-group study to evaluate the efficacy and safety of Baxdrostat in patients with uncontrolled hypertension treated with two or more medications, including patients with resistant hypertension.

Funder: ASTRAZENECA AB

Type of test: CLINICAL TRIAL WITH DRUGS

Execution time: 13/12/2023 - 30/11/2025

PI: JUAN DIEGO MEDIAVILLA GARCIA

Phase 2, randomized, double-blind, placebo-controlled study to evaluate the efficacy and safety of HZN-1116 in participants with Sjögren's syndrome.

Funder: HORIZON THERAPEUTICS IRELAND DAC

Type of test: CLINICAL TRIAL WITH DRUGS

Execution time: 07/06/2024 - 30/05/2027

IP: MONICA ZAMORA PAST

A multicenter, randomized, double-blind, placebo-controlled study evaluating the effect of inclisiran in the prevention of major adverse cardiovascular events in high-risk patients in primary prevention (VICTORION-1 PRE

Funder: NOVARTIS FARMACEUTICA, SA

Type of test: CLINICAL TRIAL WITH DRUGS

Execution time: 16/05/2023 - 30/04/2029

PI: JUAN DIEGO MEDIAVILLA GARCIA

Evaluation of the safety of Edoxaban in elderly patients with frailty criteria.

Funder: POSE

Type of test: OBSERVATIONAL STUDY WITH MEDICATION

Execution time: 24/11/2022 - 31/07/2024

PI: JUAN DIEGO MEDIAVILLA GARCIA

Phase III, randomized, double-blind, placebo-controlled, multicenter study to evaluate the efficacy and safety of KBP 5074, an ineralocorticoid receptor antagonist, in subjects with uncontrolled hypertension with moderate or severe chronic kidney disease (stage IIIb/IV ).

Funder: KBP BIOSCIENCES PTE. LTD

Type of test: COMMERCIAL CLINICAL TRIAL

Execution time: 15/07/2022 - 30/03/2024

PI: JUAN DIEGO MEDIAVILLA GARCIA

Phase 3, double-blind, placebo-controlled, multicenter, randomized study to evaluate the efficacy and safety of ORMD 0801 in patients with type 2 diabetes mellitus with inadequate glycemic control with controlled diet alone or with controlled diet and hypoglycemic agents in monotherapy.

Funder: ORAMED LTD

Type of test: COMMERCIAL CLINICAL TRIAL

Execution time: 08/06/2022 - 30/08/2023

PI: JUAN DIEGO MEDIAVILLA GARCIA

Phase II, parallel-group, double-blind study with three treatment groups to evaluate the efficacy and safety of finerenone plus empagliflozin compared to finerenone or empagliflozin in participants with chronic kidney disease and type 2 diabetes.

Funder: BAYER CONSUMER CARE AG

Type of test: COMMERCIAL CLINICAL TRIAL

Execution time: 08/04/2022 - 02/12/2023

PI: JUAN DIEGO MEDIAVILLA GARCIA

Patient preferences about treatment options for high blood pressure

Financing: SPANISH SOCIETY OF ARTERIAL HYPERTENSION

Type of test: INDEPENDENT POST-AUTHORIZATION STUDY

Execution time: 07/05/2021 - 30/12/2021

PI: JUAN DIEGO MEDIAVILLA GARCIA

Single-dose and multiple-dose ascending study to investigate the safety, tolerability, pharmacokinetics, and pharmacodynamics of azp-3601, a synthetic parathyroid hormone analog, in healthy subjects and in subjects with hypoparathyroidism.

Financer: AMOLYT PHARMA SAS

Type of test: COMMERCIAL CLINICAL TRIAL

Execution time: 26/03/2021 - 30/01/2022

PI: JUAN DIEGO MEDIAVILLA GARCIA

Observational study to evaluate the clinical management and the adequacy of the therapeutic strategies used in patients with stable atherosclerotic disease and the use of recommended treatments according to clinical guidelines. (APALUSE STUDY

Funder: CASA DEL CORAZON FOUNDATION

Type of test: INDEPENDENT POST-AUTHORIZATION STUDY

Execution time: 17/01/2020 - 30/09/2020

PI: JUAN DIEGO MEDIAVILLA GARCIA

Multi-center, blinded, randomized, PaRallEl-group, Phase 3 study with aproCltentan in Subjects with Resistant Hypertension (RHT)

Funder: IDORSIA PHARMACEUTICALS LTD

Type of test: COMMERCIAL CLINICAL TRIAL

Execution time: 25/06/2020 - 30/03/2022

PI: JUAN DIEGO MEDIAVILLA GARCIA

ReFineDR: Observational study of Routine ophthalmological tests of patients included in the two Phase 3 clinical trials, promoted by Bayer, FIDELIO and FIGARO to investigate the effect of Fineronone in delaying the progression of Retinop

Funder: BAYER AG

Type of test: COMMERCIAL POST AUTHORIZATION STUDY

Execution time: 17/09/2020 - 30/03/2021

PI: JUAN DIEGO MEDIAVILLA GARCIA

Treatment of dyslipidemic patients with high or very high risk for the prevention of cardiovascular events in Europe -Multinational Observational Study.

Funder: DAIICHI SANKYO EUROPE GMBH

Type of test: COMMERCIAL POST AUTHORIZATION STUDY

Execution time: 08/10/2020 - 30/12/2022

PI: JUAN DIEGO MEDIAVILLA GARCIA

Randomized, multicenter, double-blind, placebo-controlled trial to evaluate the safety and efficacy of individually adjusted oral doses of runcaciguat in subjects with a clinical diagnosis of chronic renal failure with diabetes and / or hypertension.

Funder: BAYER AG

Type of test: COMMERCIAL CLINICAL TRIAL

Execution time: 18/05/2020 - 12/09/2021

PI: JUAN DIEGO MEDIAVILLA GARCIA

Randomized, double-blind, placebo-controlled study of the safety and efficacy of different doses and regimens of evinacumab in patients with chronic hypercholesterolaemia despite maximum tolerated lipid-lowering therapy.

Funder: REGENERON PHARMACEUTICALS, INC

Type of test: COMMERCIAL CLINICAL TRIAL

Execution time: 15/05/2018 - 30/12/2020

PI: JUAN DIEGO MEDIAVILLA GARCIA

MP03-Internal Medicine – HVN investigates

Research lines

ISABEL SANCHEZ BERNA

RICARDO ROA CHAMORRO

PABLO GONZALEZ BUSTOS

FERNANDO JAEN AGUILA

BLANCA GAVILAN CARRERA

JUAN DIEGO MEDIAVILLA GARCIA

NURIA NAVARRETE NAVARRETE

JOSE MARIO SABIO SANCHEZ

JOSE ANTONIO VARGAS MILESTONES

MONICA ZAMORA PAST

ANTONIO DIAZ CHAMORRO

Research