MP02-Cardiovascular Pharmacology

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Our lines of research have as general objectives: to study the role of the immune system in endothelial dysfunction in hypertension, to search for strategies to modulate the intestinal flora and its integral impact on the control of blood pressure. In both cases we collaborate with the Virgen de la Nieves University Hospital in Granada and with companies such as Biosearch SA and with the Technological Center for Research and Development of Functional Food (CIDAF).

JUAN MANUEL DUARTE PEREZ

MANUEL GOMEZ GUZMAN

ROSARIO JIMENEZ MOLEÓN

MIGUEL ROMERO PEREZ

MANUEL SANCHEZ SANTOS

Lopez-Carmona, F; Toro-Ruiz, A; Gomez-Guzman, M; Valverde-Merino, MI; Piquer-Martinez, C; Zarzuelo, MJ

Community pharmacy is the key to improving vitamin D levels

EXPLORATORY RESEARCH IN CLINICAL AND SOCIAL PHARMACY, 2023;

Moleon, J; Gonzalez-Correa, C; Miñano, S; Robles-Vera, I; Barranco, AM; Gomez-Guzman, M; Sanchez, M; Riesco, P; Guerra-Hernandez, E; Toral, M; Romero, M; Duarte, J

Protective effect of microbiota-derived short chain fatty acids on vascular dysfunction in mice with systemic lupus erythematosus induced by toll like receptor 7 activation

PHARMACOLOGICAL RESEARCH, 2023;

FI: 9,3; D1

Moleón, J; González-Correa, C; Robles-Vera, I; Miñano, S; of the Visitation, N; Barranco, AM; Martín-Morales, N; O'Valle, F; Mayo-Martínez, L; García, A; Toral, M; Jiménez, R; Romero, M; Duarte, J.

Targeting the gut microbiota with dietary fibers: a novel approach to prevent the development cardiovascular complications linked to systemic lupus erythematosus in a preclinical study

GUT MICROBES, 2023;

FI: 12,2; D1

González-Correa, C; Moleón, J; Miñano, S; Robles-Vera, I; Toral, M; Martín-Morales, N; O'Valle, F; Sánchez, M; Gómez-Guzmán, M; Jiménez, R; Romero, M; Duarte, J.

Mineralocorticoid receptor blockade improved gut microbiota dysbiosis by reducing gut sympathetic tone in spontaneously hypertensive rats

BIOMEDICINE & PHARMACOTHERAPY, 2023;

FI: 7,5; Q1

Romero, M; Duarte, J

Probiotics and Prebiotics in Cardiovascular Diseases

NUTRIENTS, 2023;

FI: 5,9; Q1

Dichiara, M; Artacho-Cordon, A; Turnaturi, R; Santos-Caballero, M; Gonzalez-Cano, R; Pasquinucci, L; Barbaraci, C; Rodriguez-Gomez, I; Gomez-Guzman, M; Marrazzo, A; Cobos, EJ; Amata, E.

Dual Sigma-1 receptor antagonists and hydrogen sulfide-releasing compounds for pain treatment: Design, synthesis, and pharmacological evaluation

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022;

FI: 7,088; D1

Dichiara, M; Artacho-Cordon, A; Turnaturi, R; Santos-Caballero, M; Gonzalez-Cano, R; Pasquinucci, L; Barbaraci, C; Rodriguez-Gomez, I; Gomez-Guzman, M; Marrazzo, A; Cobos, EJ; Amata, E.

Dual Sigma-1 receptor antagonists and hydrogen sulfide-releasing compounds for pain treatment: Design, synthesis, and pharmacological evaluation.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022;

FI: 7,088; D1

Ruiz-Malagon, AJ; Rodriguez-Sojo, MJ; Hidalgo-Garcia, L; Molina-Tijeras, JA; Garcia, F; Pischel, I; Romero, M; Duarte, J; Diez-Echave, P; Rodriguez-Cabezas, ME; Rodriguez-Nogales, A; Galvez, J.

The Antioxidant Activity of Thymus serpyllum Extract Protects against the Inflammatory State and Modulates Gut Dysbiosis in Diet-Induced Obesity in Mice.

ANTIOXIDANTS, 2022;

FI: 7,675; D1

Diez-Echave, P; Vezza, T; Algieri, F; Ruiz-Malagon, AJ; Hidalgo-Garcia, L; Garcia, F; Moron, R; Sanchez, M; Toral, M; Romero, M; Duarte, J; Garrido-Mesa, J; Rodriguez-Cabezas, ME; Rodriguez-Nogales, A; Galvez, J.

The melatonergic agonist agomelatine ameliorates high fat diet-induced obesity in mice through the modulation of the gut microbiome.

BIOMEDICINE & PHARMACOTHERAPY, 2022;

FI: 7,419; D1

Gonzalez-Correa, C; Moleon, J; Minano, S; of the Visitation, N; Robles-Vera, I; Gomez-Guzman, M; Jimenez, R; Romero, M; Duarte, J.

Trimethylamine N-Oxide Promotes Autoimmunity and a Loss of Vascular Function in Toll-like Receptor 7-Driven Lupus Mice

ANTIOXIDANTS, 2022;

FI: 7,675; D1

of the Visitation, N; Robles-Vera, I; Toral, M; Gomez-Guzman, M; Sanchez, M.; Moleon, J; González-Correa, C; Martin-Morales, N.; O'Valle, F; Jimenez, R. C.; Romero, M.; Duarte, J.

Gut microbiota contributes to the development of hypertension in a genetic mouse model of systemic lupus erythematosus

BRITISH JOURNAL OF PHARMACOLOGY, 2021;

FI: 8,74; D1

of the Visitation, N; Robles-Vera, I; Moleon, J; González-Correa, C; Aguilera-Sanchez, N; Toral, M; Gomez-Guzman, M; Sanchez, M.; Jimenez, R.; Martin-Morales, N.; O'Valle, F; Romero, M.; Duarte, J.

Gut Microbiota Has a Crucial Role in the Development of Hypertension and Vascular Dysfunction in Toll-like Receptor 7-Driven Lupus Autoimmunity

ANTIOXIDANTS, 2021;

FI: 6,313; D1

Vezza, T.; Garrido-Mesa, J; Diez-Echave, P; Hidalgo-Garcia, L; Ruiz-Malagon, AJ; Garcia, F.; Sanchez, M.; Toral, M; Romero, M.; Duarte, J.; Guillamon, E; Banos, A; Moron, R.; Galvez, J.; Rodriguez-Nogales, A; Rodriguez-Cabezas, ME

Allium-Derived Compound Propyl Propane Thiosulfonate (PTSO) Attenuates Metabolic Alterations in Mice Fed a High-Fat Diet through Its Anti-Inflammatory and Prebiotic Properties

NUTRIENTS, 2021;

FI: 5,719; Q1

Robles-Vera, I; of the Visitation, N; Toral, M; Sanchez, M.; Romero, M.; Gomez-Guzman, M; Vargas, F.; Duarte, J.; Jimenez, R.

Changes in Gut Microbiota Induced by Doxycycline Influence in Vascular Function and Development of Hypertension in DOCA-Salt Rats

NUTRIENTS, 2021;

FI: 5,719; Q1

Almazan, MM; Well, JFM; Perez, J.D.M.

EVALUATION OF DOCETAXEL USE IN NON-SMALL CELL LUNG CANCER: REAL-WORLD HEALTH OUTCOMES

PHARMACY, 2021;

FI: 1,433; Q4

Robles-Vera, I; Toral, M; of the Visitation, N; Sanchez, M; Gomez-Guzman, M; Munoz, R; Algieri, F; Vezza, T; Jimenez, R; Galvez, J; Romero, M; Round, JM; Duarte, J.

Changes to the gut microbiota induced by losartan contributes to its antihypertensive effects

BRITISH JOURNAL OF PHARMACOLOGY, 2020;

FI: 7,73; D1

Alcaide-Hidalgo, JM; Romero, M; Duarte, J; Lopez-Huertas, E.

Antihypertensive Effects of Virgin Olive Oil (Unfiltered) Low Molecular Weight Peptides with ACE Inhibitory Activity in Spontaneously Hypertensive Rats

NUTRIENTS, 2020;

FI: 4,546; Q1

Martinez-Oca, P; Robles-Vera, I; Sanchez-Roncero, A; Write, F; Perez-Vizcaino, F; Duarte, J; Alvarez, C; Fernandez-Millan, E.

Gut DYSBIOSIS and altered barrier function precedes the appearance of metabolic syndrome in a rat model of nutrient-induced catch-up growth

JOURNAL OF NUTRITIONAL BIOCHEMISTRY, 2020;

FI: 4,873; Q1

Alley, M; Barbera, J.A.; Duarte, J; Perez-Vizcaino, F

Impact of Nutrition on Pulmonary Arterial Hypertension

NUTRIENTS, 2020;

FI: 4,546; Q1

de la Visitacion, N; Robles-Vera, I; Toral, M; O'Valle, F; Moleon, J; Gomez-Guzman, M; Romero, M; Duarte, M; Sanchez, M; Jimenez, R; Duarte, J

Lactobacillus fermentum CECT5716 prevents renal damage in the NZBWF1 mouse model of systemic lupus erythematosus

FOOD & FUNCTION, 2020;

FI: 4,171; Q1

Toral, M; Robles-Vera, I; of the Visitation, N; Romero, M; Sanchez, M; Gomez-Guzman, M; Rodriguez-Nogales, A; Yang, T; Jimenez, R; Algieri, F; Galvez, J; Raised, MK; Duarte, J.

Role of the immune system in vascular function and blood pressure control induced by faecal microbiota transplantation in rats.

PHYSIOLOGICAL ACT, 2019;

FI: 5,868; D1

Toral, M; Robles-Vera, I; Romero, M; de la Visitacion, N; Sanchez, M; O'Valle, F; Rodriguez-Nogales, A; Galvez, J; Duarte, J; Jimenez, R

Lactobacillus fermentum CECT5716: a novel alternative for the prevention of vascular disorders in a mouse model of systemic lupus erythematosus

FASEB JOURNAL, 2019;

FI: 5,391; D1

Hidalgo-Gutierrez, A; Barriocanal-Married, E; Bakkali, M; Diaz-Casado, ME; Sanchez-Maldonado, L; Romero, M; Sayed, R.K.; Prehn, C; Scales, G; Duarte, J; Acuna-Castroviejo, D; Lopez, L.C.

beta-RA reduces DMQ / CoQ ratio and rescues the encephalopathic phenotype in Coq9 (R239X) mice

EMBO MOLECULAR MEDICINE, 2019;

FI: 10,624; D1

of the Visitation, N; Robles-Vera, I; Toral, M; Duarte, J.

Protective Effects of Probiotic Consumption in Cardiovascular Disease in Systemic Lupus Erythematosus

NUTRIENTS, 2019;

FI: 4,171; Q1

Sanchez, M; Romero, M; Gomez-Guzman, M; Tamargo, J; Perez-Vizcaino, F; Duarte, J.

Cardiovascular Effects of Flavonoids

CURRENT MEDICINAL CHEMISTRY, 2019;

FI: 3,894; Q1

Toral, M; Romero, M; Rodriguez-Nogales, A; Jimenez, R; Robles-Vera, I; Algieri, F; Chueca-Porcuna, N; Sanchez, M; of the Visitation, N; Olivares, M; Garcia, F; Perez-Vizcaino, F; Galvez, J; Duarte, J.

Lactobacillus fermentum Improves Tacrolimus-Induced Hypertension by Restoring Vascular Redox State and Improving eNOS Coupling

MOLECULAR NUTRITION & FOOD RESEARCH, 2018;

FI: 5,151; D1

Robles-Vera, I; Toral, M; of the Visitation, N; Sanchez, M; Romero, M; Olivares, M; Jimenez, R; Duarte, J.

The Probiotic Lactobacillus fermentum Prevents Dysbiosis and Vascular Oxidative Stress in Rats with Hypertension Induced by Chronic Nitric Oxide Blockade

MOLECULAR NUTRITION & FOOD RESEARCH, 2018;

FI: 5,151; D1

Alley, M; Mondejar-Parreno, G; Barreira, B; Izquierdo-Garcia, JL; Morales-Cano, D; Esquivel-Ruiz, S; Moreno, L; Cogolludo, A; Duarte, J; Perez-Vizcaino, F

Pulmonary Arterial Hypertension Affects the Rat Gut Microbiome

SCIENTIFIC REPORTS, 2018;

FI: 4,122; Q1

Jimenez, R; Toral, M; Gomez-Guzman, M; Romero, M; Sanchez, M; Mahmoud, AM; Duarte, J.

The Role of Nrf2 Signaling in PPAR beta / delta-Mediated Vascular Protection against Hyperglycemia-Induced Oxidative Stress

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2018;

FI: 4,936; Q2

Arias, F; Camacho, ME; Carrion, M.D.; Chayah, M; Romero, M; Duarte, J; Gallo, MA

Thiadiazoline- and Pyrazoline-Based Carboxamides and Carbothioamides: Synthesis and Inhibition against Nitric Oxide Synthase

JOURNAL OF CHEMISTRY, 2018;

FI: 1,726; Q3

Romero, M; Toral, M; Robles-Vera, I; Sanchez, M; Jimenez, R; O'Valle, F; Rodriguez-Nogales, A; Perez-Vizcaino, F; Galvez, J; Duarte, J

Activation of Peroxisome Proliferator Activator Receptor/Improves Endothelial Dysfunction and Protects Kidney in Murine Lupus

HYPERTENSION, 2017;

FI: 6,857; D1

Luna-Sanchez, M; Hidalgo-Gutierrez, A; Hildebrandt, TM; Chaves-Serrano, J; Barriocanal-Married, E; Santos-Fandila, A; Romero, M; Sayed, RKA; Duarte, J; Prokisch, H; Schuelke, M; Distelmaier, F; Scales, G; Acuna-Castroviejo, D; Lopez, L.C.

CoQ deficiency causes disruption of mitochondrial sulfide oxidation, a new pathomechanism associated with this syndrome

EMBO MOLECULAR MEDICINE, 2017;

FI: 9,249; D1

Mahmoud, AM; Wilkinson, FL; McCarthy, E.M.; Moreno-Martinez, D; Langford-Smith, A; Romero, M; Duarte, J; Alexander, M.Y.

Endothelial microparticles prevent lipid-induced endothelial damage via Akt / eNOS signaling and reduced oxidative stress

FASEB JOURNAL, 2017;

FI: 5,498; D1

Romero, M; Vera, B; Galisteo, M; Toral, M; Galvez, J; Perez-Vizcaino, F; Duarte, J.

Protective vascular effects of quercitrin in acute TNBS-colitis in rats: the role of nitric oxide

FOOD & FUNCTION, 2017;

FI: 3,247; Q1

Toral, M; Jimenez, R; Romero, M; Robles-Vera, I; Sanchez, M; Salaices, M; Sage, JM; Duarte, J

Role of endoplasmic reticulum stress in the protective effects of PPAR beta / delta activation on endothelial dysfunction induced by plasma from patients with lupus

ARTHRITIS RESEARCH & THERAPY, 2017;

FI: 4,121; Q1

Toral, M; Romero, M; Jimenez, R; Robles-Vera, I; Tamargo, J; Martinez, M.C.; Perez-Vizcaino, F; Duarte, J.

Role of UCP2 in the protective effects of PPAR beta / delta activation on lipopolysaccharide-induced endothelial dysfunction

BIOCHEMICAL PHARMACOLOGY, 2016;

FI: 5,091; D1

Romero, M; Leon-Gomez, E; Lobysheva, I; Rath, G; Dogne, JM; Feron, O; Dessy, C.

Effects of BM-573 on Endothelial Dependent Relaxation and Increased Blood Pressure at Early Stages of Atherosclerosis

PLOSONE, 2016;

FI: 3,057; Q1

Romero, M; Toral, M; Gomez-Guzman, M; Jimenez, R; Galindo, P; Sanchez, M; Olivares, M; Galvez, J; Duarte, J.

Antihypertensive effects of oleuropein-enriched olive leaf extract in spontaneously hypertensive rats.

FOOD & FUNCTION, 2016;

FI: 2,686; Q1

Morales-Cano, D; Moreno, L; Barreira, B; Briones, AM; Pandolfi, R; Moral-Sanz, J; Alley, M; Mondejar-Parreno, G; Farmhouse, J; Salaices, M; Duarte, J; Perez-Vizcaino, F; Cogolludo, A

Activation of PPAR beta / delta prevents hyperglycaemia-induced impairment of Kv7 channels and cAMP-mediated relaxation in rat coronary arteries

CLINICAL SCIENCE, 2016;

FI: 5,016; Q1

Chamorro, V; Pandolfi, R; Moreno, L; Barreira, B; Martinez-Ramas, A; Morales-Cano, D; Ruiz-Cabello, J; Lorente, J.A.; Duarte, J; Cogolludo, A; Alvarez-Sala, JL; Perez-Vizcaino, F

Effects of Quercetin in a Rat Model of Hemorrhagic Traumatic Shock and Reperfusion

MOLECULES, 2016;

FI: 2,465; Q2

Gomez-Guzman, M; Toral, M; Romero, M; Jimenez, R; Galindo, P; Sanchez, M; Zarzuelo, MJ; Olivares, M; Galvez, J; Duarte, J.

Antihypertensive effects of probiotics Lactobacillus strains in spontaneously hypertensive rats

MOLECULAR NUTRITION & FOOD RESEARCH, 2015;

FI: 4,603; D1

Morales-Cano, D; Moreno, L; Barreira, B; Pandolfi, R; Chamorro, V; Jimenez, R; Villamore, E; Duarte, J; Perez-Vizcaino, F; Cogolludo, A

Kv7 channels critically determine coronary artery reactivity: left-right differences and down-regulation by hyperglycaemia

CARDIOVASCULAR RESEARCH, 2015;

FI: 5,94; D1

Tamargo, J; Duarte, J; Ruilope, L.M.

New Antihypertensive Drugs Under Development

CURRENT MEDICINAL CHEMISTRY, 2015;

FI: 3,853; D1

Blázquez-Medela AM, García-Sánchez O, Quirós Y, Blanco-Gozalo V, Prieto-García L, Sancho-Martínez SM, Romero M, Duarte JM, López-Hernández FJ, López-Novoa JM, Martínez-Salgado C.

Increased Klk9 Urinary Excretion Is Associated with Hypertension-Induced Cardiovascular Damage and Renal Alterations

MEDICINE, 2015;

FI: 5,723; D1

Toral, M; Romero, M; Jimenez, R; Mahmoud, AM; Barroso, E; Gomez-Guzman, M; Sanchez, M; Cogolludo, A; Garcia-Redondo, AB; Briones, AM; Vazquez-Carrera, M; Perez-Vizcaino, F; Duarte, J.