Ae22-Cancer Genetics, Biomarkers and Experimental Therapies (Emerging)

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Members
Publications
Projects
Clinical trials

The main objective of the multidisciplinary research group "CANCER GENETICS, BIOMARKERS AND EXPERIMENTAL THERAPIES" is to identify new biomarkers to improve the diagnosis, prognosis and treatment of cancer patients, through the study of new mechanisms of gene regulation, which they have been shown to be important for tumor development, and are currently at the frontier of knowledge; among which are: Chromatin remodeling complexes, and non-coding RNAs. Our group intends to transfer molecular findings to daily clinical practice, to make this possible, our multidisciplinary research group uses state-of-the-art technologies working with patient samples, public repositories of genomic data, cell lines and pre-clinical in vivo models. to validate the role of new biomarkers in cancer.

Research lines

Identification of new molecular biomarkers to improve the diagnosis, prognosis and treatment of cancer patients
Regulation of gene expression in cancer through the study of the SWI / SNFI complex and its interactions with miRNAs, lncRNAs and DNA

Keywords

Cancer, Biomarkers, Bioinformatics, Non-coding RNAs, SWI / SNF, miRNAs, lncRNAs

ANA UTRILLA MAESTRE

FERNANDO MONTENEGRO ELVIRA

PABLO MARTIN LOPEZ

ORCID

ANA MARIA MATIA GONZALEZ

ORCID

MARIA SOLEDAD BENITEZ CANTOS

ORCID

ANA BELEN GAMIZ MOLINA

PEDRO MEDINA VICO

FLORENCIO QUERO VALENZUELA

IMMACULADA SEGURA JIMENEZ

MARTA CUADROS CELORRIO

Benitez-Cantos, M.S.; Cano, C.; Cuadros, M.; Medina, P.P.

Activation-induced cytidine deaminase causes recurrent splicing mutations in diffuse large B-cell lymphoma

MOLECULAR CANCER, 2024;

FI: 27,7; D1

Gómez-Gago, AM; de las Heras-Marqués, B; Quero-Valenzuela, F

Late Unexpected Pneumopericardium Due to Pleuro-pericardial Atrial Perforation by Pacemaker Lead

ARCHIVES DE BRONCONEUMOLOGIA, 2024;

FI: 8,7; D1

Núñez, JM; Benitez, JR; Valenzuela, CF; Matthew, AC; Otero, AN; Ciuró, AH; Valenza, MC

Musculoskeletal Disorders Related to Upper Limb Disability after One-Year Lung Cancer Resection

CANCER, 2024;

FI: 4,5; Q1

Heredia-Ciuró, A.; Quero-Valenzuela, F.; Martín-Núñez, J.; Calvache-Mateo, A.; Valenza-Peña, G.; López-López, L.; Valenza, M.C.

Physical Deconditioning in Lung Cancer Patients Who Underwent Lung Resection Surgery in Spain: A Prospective Observational Study

CANCER, 2024;

FI: 4,5; Q1

Santiago, MG; López, LL; Valenzuela, CF; Matthew, AC; Núñez, JM; Rubio, AO; Valenza, MC

Predictive Factors for Onset of Moderate-to-Severe Disability Following Hospital Discharge Due to Rib Fractures

HEALTHCARE, 2024;

FI: 2,4; Q2

Esposito, R; Lanzos, A; Uroda, T; Ramnarayanan, S; Buechi, I; Polidori, T; Guillen-Ramirez, H; Mihaljevic, A; Merlin, B.M.; Mela, L; Zoni, E; Hovhannisyan, L; McCluggage, F; Medo, M; Basile, G; Meise, DF; Zwyssig, S; Wenger, C; Schwarz, K; Vancura, A; bosch

Tumor mutations in long noncoding RNAs enhance cell fitness (vol 14, 3342, 2023)

NATURE COMMUNICATIONS, 2023;

FI: 16,6; D1

Esposito, R; Lanzós, A; Uroda, T; Ramnarayanan, S; Büchi, I; Polidori, T; Guillen-Ramirez, H; Mihaljevic, A; Merlin, B.M.; Mela, L; Zoni, E; Hovhannisyan, L; McCluggage, F; Medo, M; Basile, G; Meise, DF; Zwyssig, S; Wenger, C; Schwarz, K; Vancura, A; Bosch-

Tumor mutations in long noncoding RNAs enhance cell fitness

NATURE COMMUNICATIONS, 2023;

FI: 16,6; D1

Patiño-Mercau, JR; Baliñas-Gavira, C; Andrades, A; Benitez-Cantos, MS; Rot, A.E.; Rodriguez, MI; Alvarez-Perez, JC; Pictures, M; Medina, PP

BCL7A is silenced by hypermethylation to promote acute myeloid leukemia

BIOMARKER RESEARCH, 2023;

FI: 11,1; D1

Castro-Gonzalez, S; Cuadros, M; Medina, PP

Clinical applications of DNA methylation profiling in lung cancer

TRANSLATIONAL LUNG CANCER RESEARCH, 2023;

FI: 4; Q2

Lopez, I; Aguinagalde, B; Urreta, I; Royo, I; Bolufer, S; Sanchez, L; Zabaleta, J; Fernandez-Monge, A; Recuero, JL; Sesma, J; Amor, S; Moradiellos, FJ; Arraras, MJ; Blanco, AI; Boada, M; Sanchez, D; Cabañero, A; Moreno, N; Cal, I; Moreno, R; Cilleruelo, A

Results in mediastinal lymph node staging of surgical lung cancer: Data from the prospective cohort of the Spanish Video-Assisted Thoracic Surgery Group

ESPANOL SURGERY, 2023;

FI: 1,9; Q3

Gallardo, A; Molina, A; Asenjo, HG; Lopez-Onieva, L; Martorell-Marugan, J; Espinosa-Martinez, M; Grinan-Lison, C; Alvarez-Perez, JC; Face, FAITH; Navarro-Marchal, SA; Carmona-Saez, P; Medina, PP; Marchal, JA; Granados-Principal, S; Sanchez-Pozo, A; Landeira, D.

EZH2 endorses cell plasticity to non-small cell lung cancer cells facilitating mesenchymal to epithelial transition and tumor colonization

ONCOGENE, 2022;

FI: 8,756; D1

Andrades, A; Alvarez-Perez, JC; Patino-Mercau, JR; Pictures, M; Balinas-Gavira, C; Medina, PP

Recurrent splice site mutations affect key diffuse large B-cell lymphoma genes

BLOOD, 2022;

FI: 25,476; D1

Hairstyle, P; Andrades, A; Pictures, M; Rodriguez, MI; Chur, IF; Garcia, DJ; Benitez-Cantos, MS; Cano, C; Zarzuela, E; Munoz, J; Loidi, C; Saiz, M; Medina, PP

Multi-omic alterations of the SWI/SNF complex defines a clinical subgroup in lung adenocarcinoma

CLINICAL EPIGENETICS, 2022;

FI: 7,259; Q1

Boyero, L; Martin-Padron, J; Farez-Vidal, ME; Rodriguez, MI; Andrades, A; Hairstyle, P; Arenas, AM; Ritore-Salazar, F; Alvarez-Perez, JC; Pictures, M; Medina, PP

PKP1 and MYC create a feedforward loop linking transcription and translation in squamous cell lung cancer

CELLULAR ONCOLOGY, 2022;

FI: 7,051; Q1

Pictures, M; Cano, C; Garcia-Rodriguez, S; Martin, J.L.; Poyatos-Andujar, A; Ruiz-Cabello, F; Pedrinaci, S; Duran, G; Benavides, M; Bautista-Ojeda, MD; Pereda, T; Benitez-Cantos, MS; Medina, P; White, A; Gonzalez, A; Lizardi, P

Acceleration of the DNA methylation clock among lynch syndrome-associated mutation carriers

BMC MEDICAL GENOMICS, 2022;

FI: 3,622; Q2

Romero, OA; Vilarrubi, A; Alburquerque-Bejar, JJ; Gomez, A; Andrades, A; Trastulli, D; Pros, E; Setien, F; Vegetables; Farre, L.; Martin-Tejera, JF; Llabata, P; Oakin, A; Saigi, M; Piulats, JM; Matias-Guiu, X; Medina, PP; Vidal, A; Villanueva, A; Sanchez-

SMARCA4 deficient tumors are vulnerable to KDM6A/UTX and KDM6B/JMJD3 blockade

NATURE COMMUNICATIONS, 2021;

FI: 14,919; D1

Rodriguez-Torres, J; Lopez-Lopez, L; Cabrera-Martos, I; Quero-Valenzuela, F; Cahalin, L.P.; Cebria-i-Iranzo, MD; Valenza, M.C.

Inpatient Step Counts, Symptom Severity, and Perceived Health Status After Lung Resection Surgery

CANCER NURSING, 2021;

FI: 2,592; Q1

Sanchez-Martin, V; Schneider, D.A.; Ortiz-González, M; Soriano-Lerma, A; Linde-Rodriguez, A; Perez-Carrasco, V; Gutierrez-Fernandez, J; Tables, M; González, C; Soriano, M; Garcia-Salcedo, J.A.

Targeting ribosomal G-quadruplexes with naphthalene-diimides as RNA polymerase I inhibitors for colorectal cancer treatment

CELL CHEMICAL BIOLOGY, 2021;

FI: 8,116; Q1

Hairstyle, P; Andrades, A; Martorell-Marugan, J; Haswell, JR; Slack, FJ; Carmona-Saez, P; Medina, P.P.

The SWI/SNF complex regulates the expression of miR-222, a tumor suppressor microRNA in lung adenocarcinoma

HUMAN MOLECULAR GENETICS, 2021;

FI: 6,15; Q1

Kiss, HJ; Rodriguez-Lara, I; Rosa-Garcia, A.

Does response time predict withdrawal decisions? Lessons from a bank-run experiment

REVIEW OF BEHAVIORAL FINANCE, 2020;

Fu, A; Alvarez-Perez, JC; Avizonis, D; Kin, T; Ficarro, S.B.; Choi, DW; Karakose, E; Badur, M.G.; Evans, L; Rosselot, C; Bridon, G; Bird, G.H.; Seo, H.S.; Dhe-Paganon, S; Kamphorst, JJ; Stewart, AF; Shapiro, AMJ; Martin, J.A.; Walensky, L.D.; Jones, R.G.; Garcia-Ocana,

Glucose-dependent partitioning of arginine to the urea cycle protects beta-cells from inflammation

NATURE METABOLISM, 2020;

Balinas-Gavira, C; Rodriguez, MI; Andrades, A; Tables, M; Alvarez-Perez, JC; Alvarez-Prado, AF; from Yebenes, VG; Sanchez-Hernandez, S; Fernandez-Vigo, E; Munoz, J; Martin, F; Ramiro, AR; Martinez-Climent, JA; Medina, PP

Frequent mutations in the amino-terminal domain of BCL7A impair its tumor suppressor role in DLBCL

LEUKEMIA, 2020;

FI: 8,665; D1

Hairstyle, P; Andrades, A; Tables, M; Rodriguez, MI; Chur, IE; Garcia, DJ; Alvarez-Perez, JC; Balinas-Gavira, C; Arenas, AM; Patino-Mercau, JR; Sanjuan-Hidalgo, J; Romero, OA; Montuenga, LM; Carretero, J; Sanchez-Cespedes, M; Medina, PP