Ae21-Epigenetics in Aging and Cancer (Emerging)

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Publications
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Clinical trials

We study the role of epigenetic heterogeneity in cancer and stem cell biology.

Research lines

Dissection of the molecular bases of epigenetic memory.
Analysis of epigenetic pathways associated with aging.
Design of therapeutic interventions with drugs that slow down or reverse aging.
Dissection of the epigenetic pathways that regulate metastatic dissemination.
Design of therapeutic interventions with epigenetic drugs in cancer.

Keywords

chromatin, cancer, circadian rhythm, genomics, epigenetics, transcriptomics, stem cell, liquid biopsy, prenatal diagnosis

JOAN DOMINGO REINES

ORCID

Isabel Maria Garcia Cabrera

SERGIO SERRANO CORRAL

Adrian Castle Linde

JIAJUN XIE

ANDREA SERRANO PRADOS

IVAN FERNANDEZ RENGEL

Mencia Espinosa Martinez

MARIA ALCAZAR FABRA

EFRES BELMONTE RECHE

ORCID

LOURDES LOPEZ ONIEVA

LOVER GALLARDO DE LOS REYES

DAVID LANDEIRA FRIAS

MARIA JOSE MOYANO RODRIGUEZ

ORCID

Espinosa-Martinez, M; Alcazar-Fabra, M; Landeira, D.

The molecular basis of cell memory in mammals: The epigenetic cycle

SCIENCE ADVANCES, 2024;

FI: 11,7; D1

Pelosi, L; Morbiato, L; Burgardt, A; Tonello, F; Bartlett, A.K.; Guerra, RM; Ferizhendi, K.K.; Desbats, MA; Rascalou, B; Marchi, M; Vázquez-Fonseca, L; August, C; Zanotti, G; Roger-Margueritat, M; Alcazár-Fabra, M; García-Corzo, L; Sánchez-Cuesta, A; Navas, P; Brea-Calvo, G; Trevisson, E; Wendisch, VF; Pagliarini, DJ; Salviati, L; Pierrel, F.

COQ4 is required for the oxidative decarboxylation of the C1 carbon of coenzyme Q in eukaryotic cells

MOLECULAR CELL, 2024;

FI: 14,5; D1

Barbosa, S; Laureano, NK; Hadiwikarta, WW; Visioli, F; Bonrouhi, M; Pajdzik, K; Conde-Lopez, C; Herold-Mende, C; Eidt, G; Langie, R; Lamers, M.L.; Stögbauer, F; Hess, J; Kurth, I; Jou, A.

The Role of SOX2 and SOX9 in Radioresistance and Tumor Recurrence

CANCER, 2024;

FI: 4,5; Q1

Pérez-Soto, M; Ramos-Soriano, J; Peñalver, P; Belmonte-Reche, E; O'Hagan, MP; Cucchiarini, A; Mergny, J.L.; Galán, MC; López, MCL; Thomas, M.D.; Morales, J.C.

DNA G-quadruplexes in the genome of Trypanosoma cruzi as potential therapeutic targets for Chagas disease: Dithienylethene ligands as effective antiparasitic agents

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024;

FI: 6; Q1

Gallardo, A; López-Onieva, L; Belmonte-Reche, E; Fernández-Rengel, I; Serrano-Prados, A; Molina, A; Sánchez-Pozo, A; Landeira, D.

EZH2 represses mesenchymal genes and upholds the epithelial state of breast carcinoma cells

CELL DEATH & DISEASE, 2024;

FI: 8,1; Q1

Asenjo, HG; Alcazar-Fabra, M; Espinosa-Martínez, M; Lopez-Onieva, L; Gallardo, A; Dimitrova, E; Feldmann, A; Pachano, T; Martorell-Marugán, J; Carmona-Sáez, P; Sanchez-Pozo, A; Rada-Iglesias, A; Klose, R.J. Landeira, D.

Changes in PRC1 activity during interphase modulate lineage transition in pluripotent cells

NATURE COMMUNICATIONS, 2023;

FI: 16,6; D1

Domingo-Reinés, J; Montes, R; Garcia-Moreno, A; Gallardo, A; Sanchez-Manas, JM; Ellson, I; Lamolda, M; Calabro, C; Lopez-Escamez, JA; Catalina, P; Carmona-Saez, P; Real, PJ; Landeira, D; Ramos-Mejia, V

The pediatric leukemia oncoprotein NUP98-KDM5A induces genomic instability that may facilitate malignant transformation

CELL DEATH & DISEASE, 2023;

FI: 9; Q1

Gallardo, A; Molina, A; Asenjo, HG; Lopez-Onieva, L; Martorell-Marugan, J; Espinosa-Martinez, M; Grinan-Lison, C; Alvarez-Perez, JC; Face, FAITH; Navarro-Marchal, SA; Carmona-Saez, P; Medina, PP; Marchal, JA; Granados-Principal, S; Sanchez-Pozo, A; Landeira, D.

EZH2 endorses cell plasticity to non-small cell lung cancer cells facilitating mesenchymal to epithelial transition and tumor colonization.

ONCOGENE, 2022;

FI: 8,756; D1

Cebrian, R; Belmonte-Reche, E; Pirota, V; de Jong, A; Morales, JC; Freccero, M; Doria, F; Kuipers, O.P.

G-Quadruplex DNA as a Target in Pathogenic Bacteria: Efficacy of an Extended Naphthalene Diimide Ligand and Its Mode of Action

JOURNAL OF MEDICINAL CHEMISTRY, 2022;

FI: 8,039; D1

Belmonte-Reche, E; Benassi, A; Penalver, P; Cucchiarini, A; Guedin, A; Mergny, J.L.; Rosu, F; Gabelica, V; Freccero, M; Doria, F; Morales, J.C.

Thiosugar naphthalene diimide conjugates: G-quadruplex ligands with antiparasitic and anticancer activity

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022;

FI: 7,088; D1

Cerqueira, M; Belmonte-Reche, E; Gallo, J; Baltazar, F; Banobre-Lopez, M

Magnetic Solid Nanoparticles and Their Counterparts: Recent Advances towards Cancer Theranostics

PHARMACEUTICS, 2022;

FI: 6,525; Q1

Goncalves, RCR; Belmonte-Reche, E; Pina, J; da Silva, MC; Pinto, SCS; Gallo, J; Costa, SPG; Raposo, MMM

Bioimaging of Lysosomes with a BODIPY pH-Dependent Fluorescent Probe

MOLECULES, 2022;

FI: 4,927; Q2

Pachano, T.; Sanchez-Gaya, V; Healo, T; Mariner-Fauli, M; Bleckwehl, T; Asenjo, H. G.; Answer, P; Cruz-Molina, S; Munoz-San Martin, M; Haro, E.; van IJcken, WFJ; Landeira, D.; Rada-Iglesias, A

Orphan CpG islands amplify poised enhancer regulatory activity and determine target gene responsiveness

NATURE GENETICS, 2021;

FI: 38,33; D1

Cortijo-Gutierrez, M; Sanchez-Hernandez, S; Tristan-Manzano, M; Maldonado-Perez, N; Lopez-Onieva, L; Royal, PJ; Herrera, C; Marchal, JA; Martin, F.; Benabdellah, K.

Improved Functionality of Integration-Deficient Lentiviral Vectors (IDLVs) by the Inclusion of IS2 Protein Docks..

PHARMACEUTICS, 2021;

FI: 6,321; Q1

Serrano-Garrido, O; Peris-Torres, C; Redondo-Garcia, S; Asenjo, H. G.; Plaza-Calonge, MD; Fernandez-Luna, JL; Rodriguez-Manzaneque, JC

ADAMTS1 Supports Endothelial Plasticity of Glioblastoma Cells with Relevance for Glioma Progression

BIOMOLECULES, 2021;

FI: 4,879; Q2

Asenjo, H. G.; Gallardo, A; Lopez-Onieva, L; Roof, I; Martorell-Marugan, J; Carmona-Saez, P; Landeira, D.

Polycomb regulation is coupled to cell cycle transition in pluripotent stem cells

SCIENCE ADVANCES, 2020;

FI: 13,117; D1

Garrido-Navas, MC; Garcia-Diaz, A; Molina-Vallejo, MP; Gonzalez-Martinez, C; Lucena, MA; Canas-Garcia, I; Bayarri, C; Slim, JR; Gonzalez, E; Lorente, J.A.; Serrano, MJ

The Polemic Diagnostic Role of TP53 Mutations in Liquid Biopsies from Breast, Colon and Lung Cancers

CANCER, 2020;

FI: 6,126; Q1

Gallardo, A; Molina, A.; Asenjo, H. G.; Martorell-Marugan, J; Montes, R; Ramos-Mejia, V; Sanchez-Pozo, A; Carmona-Saez, P; Lopez-Onieva, L; Landeira, D.

The molecular clock protein Bmal1 regulates cell differentiation in mouse embryonic stem cells

LIFE SCIENCE ALLIANCE, 2020;

FI: 2,622; Q2

Requena, F; Asenjo, H. G.; Barturen, G; Martorell-Marugan, J; Carmona-Saez, P; Landeira, D.

NOMePlot: analysis of DNA methylation and nucleosome occupancy at the single molecule

SCIENTIFIC REPORTS, 2019;

FI: 4,011; Q1

Garrido-Navas, C; from Miguel-Perez, D; Exposito-Hernandez, J; Bayarri, C; Amezcua, V; Ortigosa, A; Valdivia, J; Guerrero, R; Puche, JLG; Lorente, JA; Serrano, MJ