Ae21-Epigenetics in Stem Cells and Cancer (Emerging)
Oncology / IBS-Ae21
We study the role of epigenetic heterogeneity in cancer and stem cell biology.
Research lines
- Application of omic techniques in prenatal diagnosis.
- Polycomb proteins during development and in cancer.
- Circadian rhythms during development and in cancer.
- Use of omic techniques for the study of lung cancer.
Keywords
chromatin, cancer, circadian rhythm, genomics, epigenetics, transcriptomics, stem cell, liquid biopsy, prenatal diagnosis
JIAJUN XIE
ANDREA SERRANO PRADOS
IVAN FERNANDEZ RENGEL
Mencia Espinosa Martinez
MARIA ALCAZAR FABRA
ANTONIO SANCHEZ WELL
EFRES BELMONTE RECHE
LOURDES LOPEZ ONIEVA
CLARA ISABEL BAYARRI LARA
CRISTINA CONDE LOPEZ
LOVER GALLARDO DE LOS REYES
HELENA GOMEZ ASENJO
DAVID LANDEIRA FRIAS
XAVIER FRANCISCO LANDIVAR VARAS
ALDARA MOLINA SANCHEZ
MARIA JOSE MOYANO RODRIGUEZ
EZH2 endorses cell plasticity to non-small cell lung cancer cells facilitating mesenchymal to epithelial transition and tumor colonization.
ONCOGENE, 2022;
FI: 8,756; D1
G-Quadruplex DNA as a Target in Pathogenic Bacteria: Efficacy of an Extended Naphthalene Diimide Ligand and Its Mode of Action
JOURNAL OF MEDICINAL CHEMISTRY, 2022;
FI: 8,039; D1
Thiosugar naphthalene diimide conjugates: G-quadruplex ligands with antiparasitic and anticancer activity
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022;
FI: 7,088; D1
Magnetic Solid Nanoparticles and Their Counterparts: Recent Advances towards Cancer Theranostics
PHARMACEUTICS, 2022;
FI: 6,525; Q1
Bioimaging of Lysosomes with a BODIPY pH-Dependent Fluorescent Probe
MOLECULES, 2022;
FI: 4,927; Q2
Orphan CpG islands amplify poised enhancer regulatory activity and determine target gene responsiveness
NATURE GENETICS, 2021;
FI: 38,33; D1
Improved Functionality of Integration-Deficient Lentiviral Vectors (IDLVs) by the Inclusion of IS2 Protein Docks..
PHARMACEUTICS, 2021;
FI: 6,321; Q1
ADAMTS1 Supports Endothelial Plasticity of Glioblastoma Cells with Relevance for Glioma Progression
BIOMOLECULES, 2021;
FI: 4,879; Q2
Polycomb regulation is coupled to cell cycle transition in pluripotent stem cells
SCIENCE ADVANCES, 2020;
FI: 13,117; D1
The Polemic Diagnostic Role of TP53 Mutations in Liquid Biopsies from Breast, Colon and Lung Cancers
CANCER, 2020;
FI: 6,126; Q1
The molecular clock protein Bmal1 regulates cell differentiation in mouse embryonic stem cells
LIFE SCIENCE ALLIANCE, 2020;
FI: 2,622; Q2
NOMePlot: analysis of DNA methylation and nucleosome occupancy at the single molecule
SCIENTIFIC REPORTS, 2019;
FI: 4,011; Q1
Cooperative and Escaping Mechanisms between Circulating Tumor Cells and Blood Constituents
CELLS, 2019;
FI: 5,656; Q1
GnRH agonist treatment of luteal phase deficiency in HCG-triggered IVF cycles: a matched case-control study
REPRODUCTIVE BIOMEDICINE ONLINE, 2019;
FI: 2,93; Q1
Perioperative outcome of lung cancer surgery in women: results from a Spanish nationwide prospective cohort study
JOURNAL OF THORACIC DISEASE, 2019;
FI: 2,027; Q3
Dissecting the epigenetic cycle in stem cells
Funder: INSTITUTO DE SALUD CARLOS III
File number: IHRC22/00007
Execution time: 01/01/2023 - 31/12/2026
PI: DAVID LANDEIRA FRIAS
AID AIMED FOR ATTRACTING RESEARCH TALENT (EMERGIA PROGRAM)
Funder: DEPARTMENT OF UNIVERSITY, RESEARCH AND INNOVATION
File number: EMC21_00253
Execution time: 01/01/2023 - 31/12/2026
Role of Polycomb proteins as regulators of differentiation during the cell cycle of pluripotent cells
Funder: UNIVERSITY OF GRANADA
File number: A-BIO-6-UGR20
Execution time: 01/07/2021 - 30/06/2023
Mitotic Bookmarking By Polycomb Proteins In Stem Cell
Funder: COUNCIL OF ECONOMIC TRANSFORMATION, INDUSTRY, KNOWLEDGE AND UNIVERSITIES
File number: PY20_0068
Execution time: 04/10/2021 - 30/06/2023
PI: DAVID LANDEIRA FRIAS
POLYCOMB RECRUITMENT DURING CELL CYCLE TRANSITION
Funder: STATE RESEARCH AGENCY
File number: EUR2021-122005
Execution time: 01/12/2021 - 01/12/2023
PI: DAVID LANDEIRA FRIAS