A04-Digital and Computational Pathology, Immunopathology and Cancer
Oncology / IBS-A04 / Consolidated
Translational applied research group in cancer, gynecopathology and immunopathology. His main line of research focuses on the identification of new markers of prognostic and diagnostic interest in cancer. Research is also carried out on the pathology of oral squamous cell carcinoma, essentially aimed at the analysis of cell proliferation markers in premalignant epithelia and in tumor tissue, as well as the study of proliferation stimulated proteins. In recent years, the main line of the group has been directed to the field of expression of cancer stem cell markers in premalignant epithelium and oral cancer. Currently, through digital pathology and computational pathology tools, our research group is developing Deep-learning learning models as a new line in cancer research.
Research lines
- Identification of new markers of prognostic and diagnostic interest in cancer
- Cancer stem cell markers in premalignant epithelium and oral cancer
- Development of deep learning models to identify new patterns in cancer
- Detection of genetic markers involved in resistance to trastuzumab treatment in patients with breast cancer
- Pharmacogenetics of metastatic colon cancer in patients treated with 5FU regimens and monoclonal antibodies
- Nephropathology, kidney transplantation and uropathology. Clinicopathological and experimental models and donor pathology
- Tumor neuropathology
- Oral cavity pathology
- Pathology of the skin and soft tissues. Immunohistochemical markers in neoplasms
- Computational and digital pathology
- Gynecological pathology
- Oral and head and neck pathology
- Viral pathology: HPV and its relationship with carcinogenesis in tumors of the genital tract and other locations
Keywords
Cancer, diagnosis, prognosis, genetics, molecular
BEATRIZ RUEDA VILLAFRANCA
JULY MERINO MONTES
ALBERTO JOSE GREGORIO ALVAREZ LUCENA
OVIDIU PREDA
CESAR RAMIREZ TORTOSA
FRANCISCO MANUEL RAMOS PLEGUEZUELOS
ROSE RIVERS PELEGRINA
ANA ISABEL ROMERO ORTIZ
JOSEFA RUBI URIA
ISABEL RUIZ AVILA
ANA MARIA SEGURA PEREZ
MARIA ESTHER VERGARA ALCAIDE
CESAR GARCIA LOPEZ
RAIMUNDO GARCIA DEL MORAL GARRIDO
JOSE ANTONIO GIL MONTOYA
MIGUEL ANGEL GONZALEZ MOLES
RODRIGO LOPEZ CASTRO
JAVIER LUIS LOPEZ HIDALGO
AURELIO MARTIN CASTRO
Mª TERESA MEDINA CANO
MARGARITA MERINO ALVAREZ
IGNACIO J MOLINA PINEDA DE LAS INFANTAS
FRANCISCO JAVIER O'VALLE RAVASSA
DAVID AGUILAR PEÑA
JOSE ANEIROS FERNANDEZ
PATRICIA BECERRA MASSARE
MERCEDES CABA MOLINA
CLARA EUGENIA CHAMORRO SANTOS
IMMACULATE GARCIA PEREZ
Annotation protocol and crowdsourcing multiple instance learning classification of skin histological images: The CR-AI4SkIN dataset
ARTIFICIAL INTELLIGENCE IN MEDICINE, 2023;
FI: 7,5; Q1
Estradiol and Estrone Have Different Biological Functions to Induce NF-κB-Driven Inflammation, EMT and Stemness in ER plus Cancer Cells
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023;
FI: 6,208; Q1
Physico-chemical and biological characterization of a new bovine bone mineral matrix available for human usage
CLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH, 2023;
FI: 3,6; Q1
Mineralocorticoid receptor blockade improved gut microbiota dysbiosis by reducing gut sympathetic tone in spontaneously hypertensive rats
BIOMEDICINE & PHARMACOTHERAPY, 2023;
FI: 7,5; Q1
Oral and general health conditions involved in periodontal status during pregnancy: a prospective cohort study
ARCHIVES OF GYNECOLOGY AND OBSTETRICS, 2023;
FI: 2,6; Q3
Cortistatin regulates fibrosis and myofibroblast activation in experimental hepatotoxic- and cholestatic-induced liver injury
BRITISH JOURNAL OF PHARMACOLOGY, 2022;
FI: 9,473; D1
Challenges in the Early Diagnosis of Oral Cancer, Evidence Gaps and Strategies for Improvement: A Scoping Review of Systematic Reviews
CANCER, 2022;
FI: 6,575; Q1
Differences reported in the lifespan and aging of male Wistar rats maintained on diets containing fat with different fatty acid profiles (virgin olive, sunflower or fish oils) are not reflected by histopathological lesions found at death in central nervous and endocrine systems
FOOD AND CHEMICAL TOXICOLOGY, 2022;
FI: 5,572; Q1
Early marginal bone loss around dental implants to define success in implant dentistry: A retrospective study
CLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH, 2022;
FI: 4,259; Q1
Generation of a H9 Clonal Cell Line With Inducible Expression of NUP98-KDM5A Fusion Gene in the AAVS1 Safe Harbor Locus.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2022;
FI: 6,081; Q1
Acute pancreatitis manifesting in the skin: Pancreatic panniculitis.
GASTROENTEROLOGY JOURNAL OF MEXICO, 2021;
A Scoping Review on Gaps in the Diagnostic Criteria for Proliferative Verrucous Leukoplakia: A Conceptual Proposal and Diagnostic Evidence-Based Criteria
CANCER, 2021;
FI: 6,639; Q1
An appraisal of highest quality studies reporting malignant transformation of oral lichen planus based on a systematic review
ORAL DISEASE, 2021;
FI: 3,511; Q1
Assembling a consensus on actinic cheilitis: A Delphi study
JOURNAL OF ORAL PATHOLOGY & MEDICINE, 2021;
FI: 4,253; Q1
Blind color deconvolution, normalization, and classification of histological images using general super Gaussian priors and Bayesian inference
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE, 2021;
FI: 5,428; Q1
Algae-derived hydroxyapatite behavior as bone biomaterial in comparison with anorganic bovine bone: A split-mouth clinical, radiological, and histological randomized study in humans
CLINICAL ORAL IMPLANTS RESEARCH, 2020;
FI: 3,723; D1
A Diet Rich in Saturated Fat and Cholesterol Aggravates the Effect of Bacterial Lipopolysaccharide on Alveolar Bone Loss in a Rabbit Model of Periodontal Disease
NUTRIENTS, 2020;
FI: 4,546; Q1
A Rejection Gene Expression Score in Indication and Surveillance Biopsies Is Associated with Graft Outcome
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2020;
FI: 4,556; Q1
An update of knowledge on PD-L1 in head and neck cancers: Physiologic, prognostic and therapeutic perspectives
ORAL DISEASE, 2020;
FI: 2,613; Q1
A rare cause of chronic diarrhea
INFECTIOUS DISEASES AND CLINICAL MICROBIOLOGY, 2020;
FI: 1,654; Q4
Malignant transformation risk of oral lichen planus: A systematic review and comprehensive meta-analysis
ORAL ONCOLOGY, 2019;
FI: 3,73; D1
Formulation, Colloidal Characterization, and In Vitro Biological Effect of BMP-2 Loaded PLGA Nanoparticles for Bone Regeneration
PHARMACEUTICS, 2019;
FI: 4,773; D1
Composite Alloplastic Biomaterial vs. Autologous Platelet-Rich Fibrin in Ridge Preservation
JOURNAL OF CLINICAL MEDICINE, 2019;
FI: 5,688; D1
Biphasic hydroxyapatite and ss-tricalcium phosphate biomaterial behavior in a case series of maxillary sinus augmentation in humans
CLINICAL ORAL IMPLANTS RESEARCH, 2019;
FI: 3,825; D1
Lactobacillus fermentum CECT5716: a novel alternative for the prevention of vascular disorders in a mouse model of systemic lupus erythematosus
FASEB JOURNAL, 2019;
FI: 5,391; D1
Prognostic and clinicopathological significance of cyclin D1 expression in oral squamous cell carcinoma: A systematic review and meta-analysis
ORAL ONCOLOGY, 2018;
FI: 4,636; D1
Histopathological comparison of healing after maxillary sinus augmentation using xenograft mixed with autogenous bone versus allograft mixed with autogenous bone.
CLINICAL ORAL IMPLANTS RESEARCH, 2018;
FI: 4,305; D1
Male breast cancer: correlation between immunohistochemical subtyping and PAM50 intrinsic subtypes, and the subsequent clinical outcomes.
MODERN PATHOLOGY, 2018;
FI: 6,655; D1
Activating Transcription Factor 4 Modulates TGF beta-Induced Aggressiveness in Triple-Negative Breast Cancer via SMAD2 / 3/4 and mTORC2 Signaling
CLINICAL CANCER RESEARCH, 2018;
FI: 10,199; D1
Activating Transcription Factor 4 Modulates TGF beta-Induced Aggressiveness in Triple-Negative Breast Cancer via SMAD2 / 3/4 and mTORC2 Signaling
CLINICAL CANCER RESEARCH, 2018;
FI: 10,199; D1
Relevance of chromosomal band 11q13 in oral carcinogenesis: An update of current knowledge
ORAL ONCOLOGY, 2017;
FI: 4,794; D1
History, clinical findings, and histopathology Vulvar steatocystoma multiplex
JOURNAL OF THE DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT, 2017;
FI: 2,865; Q1
The absence of HLA class I expression in non-small cell lung cancer correlates with the tumor tissue structure and the pattern of T cell infiltration.
INTERNATIONAL JOURNAL OF CANCER, 2017;
FI: 6,513; Q1
Is mitotic rate still useful in the management of patients with thin melanoma?
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY, 2017;
FI: 3,528; Q1
Redox status in the sentinel lymph node of women with breast cancer
UPSALA JOURNAL OF MEDICAL SCIENCES, 2017;
FI: 2,389; Q1
Significance of the Immunohistochemical Expression of Bone Morphogenetic Protein-4 in Bone Maturation after Maxillary Sinus Grafting in Humans
CLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH, 2016;
FI: 4,152; D1
GATA binding protein 3 expression is present in primitive patterns of yolk sac tumors but is not expressed by differentiated variants
HISTOPATHOLOGY, 2016;
FI: 3,453; Q1
GATA binding protein 3 expression is present in primitive patterns of yolk sac tumors but is not expressed by differentiated variants
HISTOPATHOLOGY, 2016;
FI: 3,425; Q1
Keratotic Nodule on The Heel: A Quiz
DERMATO-VENEREOLOGICAL ACT, 2016;
FI: 3,72; Q1
Pigmented lymph nodes in a patient with melanoma: tattoos
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY, 2016;
FI: 3,029; Q1
Effects of region of birth, educational level and age on late presentation among men who have sex with men newly diagnosed with HIV in a network of STI / HIV counseling and testing clinics in Spain
EUROSURVEILLANCE, 2015;
FI: 5,722; D1
F-18-Fluorocholine PET / CT as a complementary tool in the follow-up of low-grade glioma: diagnostic accuracy and clinical utility
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2015;
FI: 5,383; D1
Is Periodontitis a Risk Factor for Cognitive Impairment and Dementia? A Case-Control Study
JOURNAL OF PERIODONTOLOGY, 2015;
FI: 2,706; Q1
Oral and general health-related quality of life in patients treated for oral cancer compared to control group.
HEALTH AND QUALITY OF LIFE OUTCOMES, 2015;
FI: 2,12; Q1
The Role of Polymerase Chain Reaction of High-Risk Human Papilloma Virus in the Screening of High-Grade Squamous Intraepithelial Lesions in the Anal Mucosa of Human Immunodeficiency Virus-Positive Males Having Sex with Males
PLOSONE, 2015;
FI: 3,234; Q1
Β-AMYLOID IN SALIVA AND ORAL MICROBIOTA AS POSSIBLE BIOMARKERS OF ALZHEIMER'S DISEASE. PROSPECTIVE COHORT STUDY.
Funder: UNIVERSITY OF GRANADA
File number: C-CTS-062-UGR23
Execution time: 01/01/2024 - 31/12/2026
IP: JOSE ANTONIO GIL MONTOYA
Development and preclinical validation of selective dapk1 inhibitor drugs with potent antitumor action
Funder: UNIVERSITY OF GRANADA
File number: UGR001 / A-04
Execution time: 01/01/2017 - 31/12/2018
PI: IGNACIO J MOLINA PINEDA DE LAS INFANTAS
NaoHeat: Development and preclinical validation of a therapeutic system for cancer patients based on hyperthermia with nanoliposomes and immunotherapy.
Funder: MINISTRY OF ECONOMY AND BUSINESS
File number: RTC-2017-6620-1
Execution time: 01/01/2018 - 31/12/2020
PI: IGNACIO J MOLINA PINEDA DE LAS INFANTAS