A03-Bioactive Molecules

Information
Members
Patents
Publications
Projects

The group is dedicated to the design and synthesis of antitumor drugs. The study of the structure-reactivity relationships allows us to refine the structures of the prototypes, increasing the antiproliferative activity and reducing toxicity.

Research lines

Homochiral structures obtained from ortho disubstituted benzenes, with antitumor activity
New compounds with antitumor activity as choline kinase inhibitors

Keywords

Six- and seven-membered heterocycles, antitumor drugs, purines

ANDRES MARTINEZ MORENO

SOLEDAD ROMERO TAMUDO

JOAQUIN MARIA CAMPOS ROSA

ORCID

MERIEM CHAYAH GHADDAB

ORCID

MARIA DORA CARRION PILGRIM

ANA RABBIT GARCIA

OLGA CRUZ LOPEZ

Inventors: ARANEGA JIMENEZ ANTONIA; BOULAIZ HOURIA; CAMPOS ROSA JOAQUIN MARIA; CATIVIELA MARIN CARLOS; CHOQUESILLO-LAZARTE DUANE; RABBIT GARCIA ANA; CRUZ LOPEZ OLGA; GARCIA CHAVES MARIA ANGEL; GARCIA RUIZ JUAN MANUEL; JIMENEZ SANZ ANA ISABEL; MARCHAL
Title: BENZOHETEROEPINE TARGETS
Dress: P201030415

Inventors: Campos JM; Lopez l; Marchal JA; Boulaiz H; Aránega A; Rooster MA; Espinosa A; Rodríguez-Serrano F; Rabbit, Ana
Title: NUEVAS (RS) - 7- O 9- (1,2,3,5- TETRAHIDRO-4,1-BENZOCAZEPIN-3-IL) -7H O9H-PURINAS WITH ANTITUMORAL ACTIVITY
Dress: P200802431

Inventors: ARANEGA JIMENEZ ANTONIA; CAMPOS ROSA JOAQUIN; ESPINOSA UBEDA ANTONIO; GALLO MEZO MIGUEL ANGEL; GOMEZ VIDAL JOSE ANTONIO; NUNEZ CARRETERO M DEL CARMEN; MARCHAL CORRALES JUAN ANTONIO; Rodriguez-Serrano F;
Title: (2,3-DIHYDRO-5H-1,4-BENZODIHETEROEPIN-3-IL) PURINES WITH ANTI-TUMOR ACTIVITY
Dress: P200601538

Sanches, VHD; Lobato, CC; Silva, LB; dos Santos, IVF; Barros, ED; Maciel, AD; Ferreira, EFB; da Costa, KS; Espejo-Román, JM; Rosa, JMC; Kimani, N.M.; Santos, C.B.R.

Rational Approach to New Chemical Entities with Antiproliferative Activity on Ab1 Tyrosine Kinase Encoded by the BCR-ABL Gene: An Hierarchical Biochemoinformatics Analysis

PHARMACEUTICALS, 2024;

FI: 4,3; Q1

Chayah, M; Luque-González, A; Gómez-Pérez, V; Salagre, D; Al-Shdaifat, A; Campos, JM; Conejo-García, A; Agil, A

Synthesis and Anti-Diabetic Activity of an 8-Purine Derivative as a Novel DPP-4 Inhibitor in Obese Diabetic Zücker Rats

DRUG DESIGN DEVELOPMENT AND THERAPY, 2024;

FI: 4,7; Q1

Conejo-García, A.; Jiménez-Martínez, Y.; Cámara, R.; Franco-Montalbán, F.; Peña-Martín, J.; Boulaiz, H.; Carrión, M.D.

New substituted benzoxazine derivatives as potent inducers of membrane permeability and cell death

BIOORGANIC & MEDICINAL CHEMISTRY, 2024;

FI: 3,3; Q1

Cruz-López, O; Díaz-de-Cerio, E; Rubio-Ruiz, B; Espejo-Román, JM; Peñalver, P; Morales, JC; Caboni, MF; Conejo-García, A; Verardo, V

Hydroxytyrosyl puncate: A first overview of a novel phenolipid with antiproliferative and antitrypanosomal activity

JOURNAL OF FUNCTIONAL FOODS, 2024;

FI: 3,8; Q2

Espejo-Román, JM; Rubio-Ruiz, B; Chayah-Ghaddab, M; Vega-Gutierrez, C; García-García, G; Muguruza-Montero, A; Domene, C; Sánchez-Martín, RM; Cruz-López, O; Conejo-García, A

N-aryltetrahydroisoquinoline derivatives as HA-CD44 interaction inhibitors: Design, synthesis, computational studies, and antitumor effect

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023;

FI: 6,7; Q1

Bastos, RS; de Lima, LR; Net, MFA; Yousaf, N; Cruz, JN; Campos, JM; Kimani, N.M.; Ramos, RS; Santos, C.B.R.

Design and Identification of Inhibitors for the Spike-ACE2 Target of SARS-CoV-2

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023;

FI: 5,6; Q1

de Almeida, RBM; Barbosa, DB; do Bomfim, MR; Amparo, JAO; Andrade, BS; Costa, SL; Campos, JM; Cruz, JN; Santos, CBR; Leite, FHA; Botura, MB

Identification of a Novel Dual Inhibitor of Acetylcholinesterase and Butyrylcholinesterase: In Vitro and In Silico Studies

PHARMACEUTICALS, 2023;

FI: 4,6; Q2

Santos, CBR; Lobato, CC; Ota, SSB; Silva, RC; Bittencourt, RCVS; Freitas, JJS; Ferreira, EFB; Ferreira, MB; Silva, RC; De Lima, AB; Campos, JM; Borges, RS; Bittencourt, JAHM

Analgesic Activity of 5-Acetamido-2-Hydroxy Benzoic Acid Derivatives and an In-Vivo and In-Silico Analysis of Their Target Interactions

PHARMACEUTICALS, 2023;

FI: 4,6; Q2

Silva, LB; Ferreira, EFB; Maryam; Espejo-Román, JM; Costa, GV; Cruz, JV; Kimani, N.M.; Costa, JS; Bittencourt, JAHM; Cruz, JN; Campos, JM; Santos, C.B.R.

Galantamine Based Novel Acetylcholinesterase Enzyme Inhibitors: A Molecular Modeling Design Approach

MOLECULES, 2023;

FI: 4,6; Q2

Da Costa, GV; Net, MFA; Da Silva, AKP; DeSa, EMF; Cancela, LCF; Vega, JS; Lobato, CM; Zuliani, JP; Espejo-Roman, JM; Campos, JM; Leite, FHA; Santos, C.B.R.

Identification of Potential Insect Growth Inhibitor against Aedes aegypti: A Bioinformatics Approach

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2022;

FI: 6,208; Q1

Espejo-Roman, JM; Rubio-Ruiz, B; Cano-Cortes, V; Cruz-Lopez, O; Gonzalez-Resines, S; Domene, C; Conejo-Garcia, A; Sanchez-Martin, RM

Selective Anticancer Therapy Based on a HA-CD44 Interaction Inhibitor Loaded on Polymeric Nanoparticles.

PHARMACEUTICS, 2022;

FI: 6,525; Q1

Net, MFA; Campos, JM; Cerqueira, APM; de Lima, LR; Da Costa, GV; Ramos, RD; Magalhaes, JT; Santos, CBR; Leite, FHA

Hierarchical Virtual Screening and Binding Free Energy Prediction of Potential Modulators of Aedes Aegypti Odorant-Binding Protein 1

MOLECULES, 2022;

FI: 4,927; Q2

Cruz, JV; Rosa, JMC; Kimani, N.M.; Giuliatti, S; dos Santos, CBR

The Role of Celecoxib as a Potential Inhibitor in the Treatment of Inflammatory Diseases-A Review

CURRENT MEDICINAL CHEMISTRY, 2022;

FI: 4,74; Q2

Arias, F; Camacho, ME; Carrion, MD

NMR spectroscopy study of new imidamide derivatives as nitric oxide synthase inhibitors

MAGNETIC RESONANCE IN CHEMISTRY, 2022;

FI: 2,392; Q3

Cruz-Lopez, O; Ner, M; Nerin-Fonz, F; Jimenez-Martinez, Y; Araripe, D; Marchal, JA; Boulaiz, H; Gutierrez-de-Terán, H; Campos, JM; Conejo-Garcia, A.

Design, synthesis, HER2 inhibition and anticancer evaluation of new substituted 1,5-dihydro-4,1-benzoxazepines

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2021;

FI: 5,051; Q1

Lacal, JC; Zimmerman, T.; Fields, J.M.

Choline Kinase: An Unexpected Journey for a Precision Medicine Strategy in Human Diseases

PHARMACEUTICS, 2021;

FI: 6,321; Q1

Days, AD; Dallemole, DR; Bruinsmann, F. A.; Silva, LFL; Cruz-Lopez, O; Conejo-Garcia, A; Battastini, LOVE; Campos, JM; Guterres, SS; Pohlmann, AR; Figueiro, F.

Development of bozepinib-loaded nanocapsules for nose-to-brain delivery: preclinical evaluation in glioblastoma

NANOMEDICINE, 2021;

FI: 5,307; Q1

Ferreira, E.F.B.; Silva, L.B.; Cruz, JV; Araujo, P.H.F.; Kimani, NM; Milk, FHA; Campos, JM; Santos, C.B.R.

An Overview of the alpha 4 beta 1 Integrin and the Potential Therapeutic Role of its Antagonists

CURRENT MEDICINAL CHEMISTRY, 2021;

FI: 4,53; Q2

Santos, CBR; Santos, KLB; Cruz, J.N.; Milk, FHA; Borges, RS; Taft, CA; Campos, JM; Silva, CHTP

Molecular modeling approaches of selective adenosine receptor type 2A agonists as potential anti-inflammatory drugs

JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, 2021;

FI:Not Available; Q4

deAndrade, P; Dias, AD; Figueiro, F; Towers, FC; Kawano, D.F.; Battastini, AMO; Carvalho, I; da Silva, CHTD; Fields, JM

1,2,3-Triazole tethered 2-mercaptobenzimidazole derivatives: design, synthesis and molecular assessment towards C6 glioma cell line

FUTURE MEDICINAL CHEMISTRY, 2020;

FI: 3,607; Q2

Palheta, IC; Ferreira, LR; Ok, JKL; Silva, OPP; Herculaneum, AM; Oliveira, KRHM; Neto, AMJC; Campos, JM; Santos, CBR; Borges, RS

Alkylated Sesamol Derivatives as Potent Antioxidants

MOLECULES, 2020;

FI: 3,267; Q2

dos Santos, KLB; Cross, JN; Silva, L.B.; Ramos, RS; Net, MFA; Lobato, C.C.; Ota, SSB; Leite, FHA; Borges, RS; da Silva, CHTP; Fields, JM; Santos, CBR

Identification of Novel Chemical Entities for Adenosine Receptor Type 2A Using Molecular Modeling Approaches

MOLECULES, 2020;

FI: 3,267; Q2

Araujo, PHF; Ramos, RS; da Cruz, JN; Silva, SG; Ferreira, EFB; from Lima, LR; Macedo, WJC; Mirror-Roman, JM; Campos, JM; Santos, CBR

Identification of Potential COX-2 Inhibitors for the Treatment of Inflammatory Diseases Using Molecular Modeling Approaches.

MOLECULES, 2020;

FI: 3,267; Q2

Romagnoli, R; Oliva, P; Salvador, MK; Camacho, ME; Padroni, C; Brancale, A; Ferla, S; Hamel, E; Snore; Grillo, E; Bortolozzi, R; Rruga, F; Mariotto, E; Viola, G

Design, synthesis and biological evaluation of novel vicinal diaryl-substituted 1H-Pyrazole analogues of combretastatin A-4 as highly potent tubulin polymerization inhibitors.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019;

FI: 4,833; D1

Bittencourt, JAHM; Net, MFA; Lacerda, PS; Bittencourt, RCVS; Silva, RC; Lobato, C.C.; Silva, L.B.; Leite, FHA; Zuliani, J.P.; Pink, JMC; Borges, RS; Santos, CBR

In Silico Evaluation of Ibuprofen and Two Benzoylpropionic Acid Derivatives with Potential Anti-Inflammatory Activity

MOLECULES, 2019;

FI: 3,06; Q2

Borges, RS; Palheta, IC; Ota, SSB; Morais, R.B.; Muds, VA; Ramos, RS; Silva, RC; Coast, J.D.; Silva, CHTP; Fields, JM; Santos, CBR

Toward of Safer Phenylbutazone Derivatives by Exploration of Toxicity Mechanism

MOLECULES, 2019;

FI: 3,06; Q2

Ferreira, EFB; Silva, L.B.; Coast, G.V.; Coast, JS; Fujishima, MAT; Leao, R.P.; Ferreira, ALS; Frederick, L.B.; Silva, CHTP; Pink, JMC; Macedo, WJC; Santos, CBR

Identification of New Inhibitors with Potential Antitumor Activity from Polypeptide Structures via Hierarchical Virtual Screening

MOLECULES, 2019;

FI: 3,06; Q2

Fernandez-Saez, N; Fields, JM; Camacho, ME; Carrion, MD

NMR studies of new heterocycles tethered to purine moieties with anticancer activity

MAGNETIC RESONANCE IN CHEMISTRY, 2019;

FI: 1,731; Q3

Ramirez, A; Rabbit-Garcia, A; Grinan-Lison, C; Lopez-Cara, LC; Jimenez, G; Fields, JM; Marchal, J.A.; Boulaiz, H.

Enhancement of Tumor Cell Death by Combining gef Gene Mediated Therapy and New 1,4-Benzoxazepin-2,6-Dichloropurine Derivatives in Breast Cancer Cells

FRONTIERS IN PHARMACOLOGY, 2018;

FI: 3,831; Q1

Del Ponte, G; Archanjo, FC; Watanabe, L.Y.; Donate, PM; Fields, JM

Syntheses of non-aromatic medium and large rings synthesized via phenylnitrenium ions

ARABIAN JOURNAL OF CHEMISTRY, 2018;

FI: 2,969; Q2

Mahfoudh, N; Marin-Ramos, NI; Gil, AM; Jimenez, AI; Choquesillo-Lazarte, D; Kawano, D.F.; Fields, JM; Cativiela, C.

Cysteine-based 3-substituted 1,5-benzoxathiepin derivatives: Two new classes of anti-proliferative agents

ARABIAN JOURNAL OF CHEMISTRY, 2018;

FI: 2,969; Q2

Gonzalez-Martinez, D; Fernandez-Saez, N; Cativiela, C; Fields, JM; Gotor-Fernandez, V.

Development of Biotransamination Reactions towards the 3,4-Dihydro-2H-1,5-benzoxathiepin-3-amine Enantiomers

CATALYSTS, 2018;

FI: 3,465; Q2

Costa, JD; Ramos, RD; Costa, KDL; Brazil, DDB; da Silva, CHTD; Ferreira, EFB; Borges, RD; Campos, JM; Macedo, WJD; dos Santos, CBR

An In Silico Study of the Antioxidant Ability for Two Caffeine Analogs Using Molecular Docking and Quantum Chemical Methods

MOLECULES, 2018;

FI: 3,098; Q2

Cruz-Lopez, O; Ramirez, A; Navarro, SA; Garcia, MA; Marchal, JA; Campos, JM; Rabbit-Garcia, A

1- (Benzenesulfonyl) -1,5-dihydro-4,1-benzoxazepine as a new scaffold for the design of antitumor compounds

FUTURE MEDICINAL CHEMISTRY, 2017;

FI: 3,556; Q1

Morales, F; Ramirez, A; Morata-Tarifa, C; Navarro, SA; Marchal, JA; Campos, JM; Rabbit-Garcia, A

Antitumor activity of 1,2-diaminocyclohexane derivatives in breast, colon and skin human cancer cells

FUTURE MEDICINAL CHEMISTRY, 2017;

FI: 3,556; Q1

Camacho, ME; Carrion, M.D.; Chayah, M; Fields, JM

The use of wiki to promote students' learning in higher education (Degree in Pharmacy)

INTERNATIONAL JOURNAL OF EDUCATIONAL TECHNOLOGY IN HIGHER EDUCATION, 2016;

Serran-Aguilera, L; Denton, H; Rubio-Ruiz, B; Lopez-Gutierrez, B; Train, A; Left, L; Smith, TK; Conejo-Garcia, A; Hurtado-Guerrero, R

Plasmodium falciparum Choline Kinase Inhibition Leads to a Major Decrease in Phosphatidylethanolamine Causing Parasite Death

SCIENTIFIC REPORTS, 2016;

FI: 5,228; Q1

Garcia-Rubino, ME; Lozano-Lopez, C; Fields, JM

Inhibitors of Cancer Stem Cells

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, 2016;

FI: 2,722; Q2

Gonzalez-Perez, JM; Choquesillo-Lazarte, D; Dominguez-Martin, A; Vilchez-iodriguez, E; Perez-Toro, I; Castineiras, A; Arriortua, OK; Garcia-Rubino, ME; Matilla-Hernandez, A; Niclos-Gutierrez, J.

Metal binding pattern of acyclovir in ternary copper (II) complexes having an S-thioether or S-disulfide NO2S-tripodal tetradentate chelator

INORGANIC CHEMISTRY ACT, 2016;

FI: 1,918; Q2

Morales, F; Campos, JM; Rabbit-Garcia, A

H-1 and C-13 NMR spectral data of p-nitrobenzenesulfonamides and dansylsulfonamides derived from N-alkylated o- (purinemethyl) anilines

MAGNETIC RESONANCE IN CHEMISTRY, 2016;

FI: 1,226; Q3

Towers, FC; Garcia-Rubino, ME; Lozano-Lopez, C; Kawano, D.F.; Eifler-Lima, VL; von Poser, G.L.; Fields, JM

Imidazoles and Benzimidazoles as Tubulin-Modulators for Anti-Cancer Therapy

CURRENT MEDICINAL CHEMISTRY, 2015;

FI: 3,853; D1

Gomez-Perez, V; Manzano, J. I.; Garcia-Hernandez, R; Castanys, S; Gamarro, F; Fields, JM

Design, synthesis and anti-leishmanial activity of novel symmetrical bispyridinium cyclophanes.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2015;

FI: 3,447; Q1

Morales, F; Rabbit-Garcia, A; Ramirez, A; Morata, C; Marchal, J.A.; Fields, JM

p-Nitrobenzenesulfonamides and their fluorescent dansylsulfonamides derived from N-alkylated o- (purine-methyl) anilines as novel antitumor agents

CSR ADVANCES, 2015;

FI: 3,84; Q1

Lacal, JC; Fields, JM

Preclinical Characterization of RSM-932A, a Novel Anticancer Drug Targeting the Human Choline Kinase Alpha, an Enzyme Involved in Increased Lipid Metabolism of Cancer Cells

MOLECULAR CANCER THERAPEUTICS, 2015;

FI: 5,683; Q1

Gonzalez-Perez, JM; Choquesillo-Lazarte, D; Dominguez-Martin, A; El Bakkali, H; Garcia-Rubino, ME; Perez-Toro, I; Vilchez-Rodriguez, E; Castineiras, A; Nurchi, VM; Niclos-Gutierrez, J.