CA22114 - Maternal Perinatal Stress and Adverse Outcomes in the Offspring: Maximizing infants development (TREASURE)

ibs.GRANADA · International Networks

High levels of maternal perinatal stress are associated with negative effects on the offspring. The adverse impact maternal stress can have on the infants' health is 1) in the short term (prematurity, low infant birthweight); 2) the long-term (neuroinflammation, autism); 3) the very long-term (transgenerational effects). Previous studies have reported maternal stress can have transgenerational consequences. During pregnancy, high levels of maternal stress can cross the placenta and reach the fetus. Mediators responsible for the impact of maternal stress on the developing fetus include cytokines, tryptophan, cortisol, cathecolamines, reactive oxygen species, oxidative stress and microbiota. These mediators, along with epigenetic mechanisms, are involved in the adverse consequences high levels of maternal stress can have in the offspring.

In order to improve fetal development and boost infant's health throughout their lifespan, the TREASURE project aims to consolidate a multidisciplinary and international network of scientists, clinicians, students, stakeholders, Non-Governmental Organizations
(NGOs) and Enterprises to achieve impact through a three-fold main objective: 1) discovering, reviewing and disseminating scientific evidence on minimizing, reducing and preventing the impact of maternal perinatal stress on fetal development, and to improve psychological, medical and neural development in the offspring during their life-span; 2) bridging knowledge, evidence and experience between scientific disciplines, and bringing international research groups together to increase knowledge exchange between countries. 3) forming international coalitions to efficiently translate scientific knowledge into clinical guidelines and best practices across Europe to improve the health of children, and reducing economic cost appearing from high levels of maternal perinatal stress.